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$53+ Cheap flights from South Carolina to Indianapolis (IND)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/18. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — IND
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from South Carolina to Indianapolis

Cheapest flights from South Carolina to Indianapolis
Explore the most affordable flight options available from South Carolina to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/176:11 pmCHS - IND
1 stop5h 09mSpirit Airlines
Wed 11/195:05 amIND - CHS
1 stop12h 01mSpirit Airlines
Deal found 10/28$118
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/139:02 amCHS - IND
2 stops14h 27mSpirit Airlines
Mon 11/175:05 amIND - CHS
1 stop12h 01mSpirit Airlines
Deal found 10/28$138
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/265:35 amCLT - IND
1 stop15h 33mSpirit Airlines
Wed 12/36:07 pmIND - CLT
1 stop5h 06mSpirit Airlines
Deal found 10/29$163
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/255:35 amCLT - IND
1 stop15h 33mSpirit Airlines
Tue 12/26:07 pmIND - CLT
1 stop5h 06mSpirit Airlines
Deal found 10/28$164
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/52:05 pmCLT - IND
1 stop18h 39mMultiple Airlines
Wed 11/125:05 amIND - CLT
1 stop14h 53mMultiple Airlines
Deal found 10/29$167
This Cheapflightsfares deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/132:46 pmMYR - IND
1 stop8h 43mSpirit Airlines
Sun 11/165:05 amIND - MYR
1 stop5h 03mSpirit Airlines
Deal found 10/30$167
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/258:31 amCHS - IND
1 stop8h 41mSpirit Airlines
Mon 12/16:07 pmIND - CHS
1 stop13h 19mSpirit Airlines
Deal found 10/28$168
This Mytrip deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/188:28 amSAV - IND
1 stop14h 52mSpirit Airlines
Mon 11/246:07 pmIND - SAV
1 stop14h 58mSpirit Airlines
Deal found 10/30$170
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:00 amCLT - IND
1 stop17h 20mMultiple Airlines
Fri 11/148:59 pmIND - CLT
1 stop15h 24mMultiple Airlines
Deal found 10/29$171
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/410:33 pmCLT - IND
1 stop12h 03mFrontier
Sun 12/710:48 amIND - CLT
1 stop22h 49mFrontier
Deal found 10/28$172
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:11 pmCHS - IND
1 stop5h 09mSpirit Airlines
Sun 11/165:05 amIND - CHS
1 stop12h 01mSpirit Airlines
Deal found 10/28$173
This Trip.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/101:20 pmCLT - IND
1 stop10h 00mMultiple Airlines
Mon 11/1710:14 pmIND - CLT
1 stop15h 18mMultiple Airlines
Deal found 10/28$173

Cheap flight deals from South Carolina to Indianapolis

Keep the following information in mind while searching for South Carolina to Indianapolis flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$118
(Mytrip)

One-way from

$53
(Cheapflightsfares)

Popular in

March

Cheapest in

August

Average price

$333

Good one-way deal

$119 or less
Provider with most accurate pricing for Myrtle Beach Intl-Indianapolis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Indianapolis flights.
Search Deals
From South Carolina to Indianapolis
Search Deals
One-way flight from South Carolina to Indianapolis
Search Deals
Highest demand for flights based on searches. 32% potential increase in price ($187 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($34 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals
Price to beat on a one-way flight from South Carolina to Indianapolis.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from South Carolina to Indianapolis that are best for you.

Fly from

South Carolina

Fly to

Indianapolis

Route

Depart

Return

Price

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Thu 11/13

2:46 pm-11:29 pm

1 stop8h 43m

Indianapolis

Sun 11/16

5:05 am-10:08 am

1 stop5h 03m

$167

SavannahIndianapolis

SAV - IND

SAVIND

Savannah/Hilton Head

Tue 11/18

8:28 am-11:20 pm

1 stop14h 52m

Indianapolis

Mon 11/24

6:07 pm-9:05 am

1 stop14h 58m

$170

CharlotteIndianapolis

CLT - IND

CLTIND

Charlotte Douglas

Thu 12/4

10:33 pm-10:36 am

1 stop12h 03m

Indianapolis

Sun 12/7

10:48 am-9:37 am

1 stop22h 49m

$172

CharlestonIndianapolis

CHS - IND

CHSIND

Charleston

Thu 11/13

6:11 pm-11:20 pm

1 stop5h 09m

Indianapolis

Sun 11/16

5:05 am-5:06 pm

1 stop12h 01m

$173

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Fri 11/14

2:46 pm-12:51 am

1 stop10h 05m

Indianapolis

Sun 11/16

5:05 am-10:08 am

1 stop5h 03m

$173

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Fri 11/14

2:46 pm-12:51 am

1 stop10h 05m

Indianapolis

Tue 11/18

5:05 am-10:08 am

1 stop5h 03m

$173

CharlestonIndianapolis

CHS - IND

CHSIND

Charleston

Wed 11/26

8:31 am-9:08 pm

1 stop12h 37m

Indianapolis

Wed 12/3

5:00 am-5:20 pm

1 stop12h 20m

$174

CharlestonIndianapolis

CHS - IND

CHSIND

Charleston

Thu 11/27

2:59 pm-8:08 am

1 stop17h 09m

Indianapolis

Mon 12/8

11:19 am-8:37 am

1 stop21h 18m

$176

CharlestonIndianapolis

CHS - IND

CHSIND

Charleston

Thu 11/27

8:31 am-11:24 pm

1 stop14h 53m

Indianapolis

Mon 12/1

9:29 pm-8:37 am

1 stop11h 08m

$178

CharlestonIndianapolis

CHS - IND

CHSIND

Charleston

Thu 1/22

11:40 am-12:32 am

1 stop12h 52m

Indianapolis

Sat 1/24

5:06 pm-8:33 am

1 stop15h 27m

$188

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/30

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Indianapolis

What is the cheapest month to book a flight from South Carolina to Indianapolis?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Indianapolis (average of $40). Flying from South Carolina to Indianapolis in January is currently the most expensive (average of $107). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IND?

Find hourly flight availability from South Carolina to Indianapolis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

A simple way to save on the total cost of your ticket is to fly from South Carolina to Indianapolis in the afternoon. If you’re flexible enough to do this you can expect to save up to 57% on your trip compared to booking a flight at noon.

What is the cheapest day to fly from South Carolina to Indianapolis?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Indianapolis. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their South Carolina to Indianapolis flight should consider departing on Monday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Indianapolis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Indianapolis from South Carolina?

    Indianapolis (IND) is the airport you will fly into if you book a flight from South Carolina to Indianapolis. It is only a 8.3 mi journey from Indianapolis (IND) to Indianapolis’s city center.

  • How popular is this South Carolina to Indianapolis flight route?

    The South Carolina to Indianapolis flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from South Carolina to Indianapolis?

    A quick flight from South Carolina to Indianapolis can take about 3h 50m. Spirit Airlines provides one of the quickest options available for as low as $191. The distance between South Carolina and Indianapolis is about 490 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from South Carolina to Indianapolis one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $53. However, be on the lookout for offers from Allegiant Air and Delta, as they are both options that can get you from South Carolina to Indianapolis for a low price.

  • What are the most popular routes from South Carolina to Indianapolis?

    When deciding which route to take from South Carolina to Indianapolis consider Charlotte Douglas - Indianapolis, Charleston - Indianapolis or Greenville - Indianapolis as they are the most popular.

  • Can I find deals for flights from South Carolina to Indianapolis that include hotel bookings?

    Yes. In addition to deals on South Carolina to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Indianapolis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Indianapolis.

  • Can I find deals for business class flights from South Carolina to Indianapolis?

    Yes. Cheapflights offers flight deals from South Carolina to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Indianapolis?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Indianapolis (average of $40). Flying from South Carolina to Indianapolis in January is currently the most expensive (average of $107). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Terre Haute
Muncie
Noblesville
Fishers
Greenwood
Anderson
Kokomo
Bloomington
Plainfield
Franklin
Carmel
Crawfordsville
Speedway

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Alternative routes for South Carolina to Indianapolis

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from South Carolina to Indianapolis

Discover the top 6 airlines that operate flights from South Carolina to Indianapolis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$45Average$133FlexibilityNo cancel feeOn-time88%
Spirit AirlinesCheapest$146Average$257FlexibilityNo cancel feeOn-time65%
SouthwestCheapest$189Average$386FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$190Average$424FlexibilityNo cancel feeOn-time69%
DeltaCheapest$220Average$367FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$388FlexibilityNo cancel feeOn-time71%

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