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$62+ Cheap flights from South Carolina to Indianapolis (IND)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/14. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — IND
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from South Carolina to Indianapolis

Cheapest flights from South Carolina to Indianapolis
Explore the most affordable flight options available from South Carolina to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Priceline deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:00 amMYR - IND
1 stop9h 56mSpirit Airlines
Sun 1/44:51 pmIND - MYR
1 stop7h 08mSpirit Airlines
Deal found 12/16$193
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/291:23 pmSAV - IND
1 stop17h 50mSpirit Airlines
Fri 1/28:48 amIND - SAV
1 stop27h 40mSpirit Airlines
Deal found 12/16$242
This Super.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/242:51 pmCLT - IND
1 stop25h 30mFrontier
Mon 1/55:05 pmIND - CLT
1 stop23h 37mFrontier
Deal found 12/16$246
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:04 pmCLT - IND
2 stops14h 29mMultiple Airlines
Mon 1/55:05 pmIND - CLT
1 stop23h 37mMultiple Airlines
Deal found 12/16$251
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:40 pmSAV - IND
1 stop6h 31mAmerican Airlines
Thu 1/15:32 pmIND - SAV
1 stop6h 41mAmerican Airlines
Deal found 12/16$255
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:00 amSAV - IND
2 stops35h 44mMultiple Airlines
Fri 1/212:38 pmIND - SAV
1 stop10h 10mMultiple Airlines
Deal found 12/16$269
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/3010:02 pmCAE - IND
1 stop14h 06mMultiple Airlines
Fri 1/25:07 pmIND - CAE
1 stop20h 40mMultiple Airlines
Deal found 12/17$273
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:59 pmCAE - IND
1 stop4h 21mAmerican Airlines
Thu 1/18:11 pmIND - CAE
1 stop3h 56mAmerican Airlines
Deal found 12/17$279
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/317:37 pmCAE - IND
1 stop4h 22mUnited Airlines
Sun 1/45:45 amIND - CAE
1 stop4h 20mUnited Airlines
Deal found 12/16$285
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:38 pmCLT - IND
1 stop13h 55mSpirit Airlines
Wed 12/314:51 pmIND - CLT
1 stop18h 12mSpirit Airlines
Deal found 12/17$293
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/242:30 pmCAE - IND
1 stop7h 29mUnited Airlines
Thu 12/252:35 pmIND - CAE
1 stop4h 24mUnited Airlines
Deal found 12/17$305
This Kiwi.com deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:04 pmCLT - IND
2 stops14h 29mMultiple Airlines
Wed 12/314:51 pmIND - CLT
1 stop18h 12mMultiple Airlines
Deal found 12/17$308

Find flight deals from South Carolina to Indianapolis

Keep the following information in mind while searching for South Carolina to Indianapolis flight deals. Data was last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$129
(Mytrip)

One-way from

$62
(Mytrip)

Popular in

March

Cheapest in

August

Average price

$326

Good one-way deal

$119 or less
Provider with most accurate pricing for Myrtle Beach Intl-Indianapolis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Indianapolis flights.
Search Deals
From South Carolina to Indianapolis
Search Deals
One-way flight from South Carolina to Indianapolis
Search Deals
Highest demand for flights based on searches. 29% potential increase in price ($162 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($35 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a one-way flight from South Carolina to Indianapolis.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from South Carolina to Indianapolis that are best for you.

Fly from

South Carolina

Fly to

Indianapolis

Route

Depart

Return

Price

SavannahIndianapolis

SAV - IND

SAVIND

Savannah/Hilton Head

Mon 3/2

9:35 am-10:48 pm

1 stop13h 13m

Indianapolis

Mon 3/9

9:48 pm-11:34 pm

Nonstop1h 46m

$129

CharlotteIndianapolis

CLT - IND

CLTIND

Charlotte Douglas

Thu 1/22

11:12 am-7:36 pm

1 stop8h 24m

Indianapolis

Sun 1/25

9:34 pm-9:30 am

1 stop11h 56m

$154

CharlotteIndianapolis

CLT - IND

CLTIND

Charlotte Douglas

Mon 1/26

1:24 pm-10:48 pm

1 stop9h 24m

Indianapolis

Thu 1/29

10:38 am-4:54 pm

1 stop6h 16m

$157

CharlestonIndianapolis

CHS - IND

CHSIND

Charleston

Fri 1/9

5:05 pm-12:18 am

1 stop7h 13m

Indianapolis

Sun 1/11

6:55 am-4:10 pm

1 stop9h 15m

$161

CharlotteIndianapolis

CLT - IND

CLTIND

Charlotte Douglas

Thu 1/22

1:24 pm-10:48 pm

1 stop9h 24m

Indianapolis

Sun 1/25

8:26 pm-8:11 am

1 stop11h 45m

$162

CharlotteIndianapolis

CLT - IND

CLTIND

Charlotte Douglas

Thu 2/26

1:24 pm-7:23 pm

1 stop5h 59m

Indianapolis

Mon 3/2

5:15 am-6:02 pm

1 stop12h 47m

$162

CharlotteIndianapolis

CLT - IND

CLTIND

Charlotte Douglas

Thu 1/15

1:24 pm-10:48 pm

1 stop9h 24m

Indianapolis

Sat 1/17

11:55 am-12:40 am

2 stops12h 45m

$184

CharlestonIndianapolis

CHS - IND

CHSIND

Charleston

Fri 1/23

5:05 pm-11:26 am

1 stop18h 21m

Indianapolis

Sun 1/25

9:34 pm-4:10 pm

2 stops18h 36m

$186

CharlotteIndianapolis

CLT - IND

CLTIND

Charlotte Douglas

Sat 1/31

6:00 am-6:23 pm

2 stops12h 23m

Indianapolis

Sat 2/7

5:10 am-1:51 pm

1 stop8h 41m

$187

CharlotteIndianapolis

CLT - IND

CLTIND

Charlotte Douglas

Sun 1/18

11:21 am-3:34 pm

2 stops28h 13m

Indianapolis

Wed 1/21

5:10 am-10:55 am

1 stop5h 45m

$192

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Indianapolis

What is the cheapest month to book a flight from South Carolina to Indianapolis?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Indianapolis (average of $40). Flying from South Carolina to Indianapolis in January is currently the most expensive (average of $98). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IND?

Find hourly flight availability from South Carolina to Indianapolis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

A simple way to save on the total cost of your ticket is to fly from South Carolina to Indianapolis in the afternoon. If you’re flexible enough to do this you can expect to save up to 57% on your trip compared to booking a flight at noon.

What is the cheapest day to fly from South Carolina to Indianapolis?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Indianapolis. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their South Carolina to Indianapolis flight should consider departing on Monday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Indianapolis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Indianapolis from South Carolina?

    Indianapolis (IND) is the airport you will fly into if you book a flight from South Carolina to Indianapolis. It is only a 8.3 mi journey from Indianapolis (IND) to Indianapolis’s city center.

  • How popular is this South Carolina to Indianapolis flight route?

    The South Carolina to Indianapolis flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from South Carolina to Indianapolis?

    A quick flight from South Carolina to Indianapolis can take about 3h 46m. Spirit Airlines provides one of the quickest options available for as low as $247. The distance between South Carolina and Indianapolis is about 500 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from South Carolina to Indianapolis one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $150. However, be on the lookout for offers from Delta and Frontier, as they are both options that can get you from South Carolina to Indianapolis for a low price.

  • What are the most popular routes from South Carolina to Indianapolis?

    When deciding which route to take from South Carolina to Indianapolis consider Charlotte Douglas - Indianapolis, Charleston - Indianapolis or Greenville - Indianapolis as they are the most popular.

  • Can I find deals for flights from South Carolina to Indianapolis that include hotel bookings?

    Yes. In addition to deals on South Carolina to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Indianapolis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Indianapolis.

  • Can I find deals for business class flights from South Carolina to Indianapolis?

    Yes. Cheapflights offers flight deals from South Carolina to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Indianapolis?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Indianapolis (average of $40). Flying from South Carolina to Indianapolis in January is currently the most expensive (average of $98). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Terre Haute
Muncie
Noblesville
Fishers
Greenwood
Plainfield
Anderson
Kokomo
Franklin
Carmel
Crawfordsville
Bloomington
Speedway

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Top 6 airlines flying from South Carolina to Indianapolis

Discover the top 6 airlines that operate flights from South Carolina to Indianapolis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$45Average$133FlexibilityNo cancel feeOn-time88%
Spirit AirlinesCheapest$146Average$202FlexibilityNo cancel feeOn-time65%
SouthwestCheapest$189Average$388FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$190Average$340FlexibilityNo cancel feeOn-time69%
DeltaCheapest$216Average$362FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$396FlexibilityNo cancel feeOn-time71%

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