How popular is this South Carolina to Indianapolis flight route?

The South Carolina to Indianapolis flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

How long is the flight from South Carolina to Indianapolis?

A quick flight from South Carolina to Indianapolis can take about 3h 53m. Southwest provides one of the quickest options available for as low as $177. The distance between South Carolina and Indianapolis is about 427 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines to fly from South Carolina to Indianapolis one-way?

The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $74. However, be on the lookout for offers from Frontier and Delta, as they are both options that can get you from South Carolina to Indianapolis for a low price.

In terms of precipitation, rainfall in Indianapolis ranges from 2.3 - 5.1 inches per month. May is typically the wettest month, when rainfall can reach 5.1 in. February is typically the driest time to visit Indianapolis when rainfall is around 2.3 in.

If weather is an important factor for your trip to Indianapolis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 75.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 28.4 F).

What are the most popular routes from South Carolina to Indianapolis?

When deciding which route to take from South Carolina to Indianapolis consider Charlotte Douglas - Indianapolis, Columbia Metropolitan - Indianapolis or Greenville - Indianapolis as they are the most popular.

What are the most popular airlines that fly from South Carolina to Indianapolis?

Before booking your flight from South Carolina to Indianapolis check out the most popular airlines for this route: American Airlines, Delta or Allegiant Air.

What airport do you fly into for flights to Indianapolis from South Carolina?

Indianapolis (IND) is the airport you will fly into if you book a flight from South Carolina to Indianapolis. It is only a 8.3 mi journey from Indianapolis (IND) to Indianapolis’s city center.

Can I find deals for flights from South Carolina to Indianapolis that include hotel bookings?

Yes. In addition to deals on South Carolina to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from South Carolina to Indianapolis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Indianapolis.

Can I find deals for business class flights from South Carolina to Indianapolis?

Yes. Cheapflights offers flight deals from South Carolina to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$71+ Flights from South Carolina to Indianapolis

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Cheap flight deals from South Carolina to Indianapolis

Round-trip from	$161 (Kiwi.com)
One-way from	$71 (Kiwi.com)
Popular in	March
Cheapest in	August
Average price	$308
Good one-way deal	$119 or less

From South Carolina to Indianapolis

Search Deals

One-way flight from South Carolina to Indianapolis

Search Deals

Highest demand for flights based on searches. 34% potential increase in price ($192 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 10% potential price decrease ($35 potential savings vs. average RT price).

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Average for round-trip flights in September 2025

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Price to beat on a one-way flight from South Carolina to Indianapolis.

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Find flight deals from South Carolina to Indianapolis

Cheapest flights from South Carolina to Indianapolis
Explore the most affordable flight options available from South Carolina to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

Sat 12/67:31 pmCLT - IND

1 stop5h 01mSpirit Airlines

Wed 12/101:28 pmIND - CLT

1 stop9h 54mSpirit Airlines

Deal found 9/14

$161

Wed 12/31:39 pmCLT - IND

1 stop10h 53mSpirit Airlines

Fri 12/56:39 pmIND - CLT

Nonstop1h 56mSpirit Airlines

Deal found 9/14

$162

Fri 10/35:38 pmCLT - IND

1 stop22h 36mMultiple Airlines

Sun 10/57:06 pmIND - CLT

Nonstop1h 45mMultiple Airlines

Deal found 9/13

$163

Mon 12/83:55 pmCLT - IND

Nonstop1h 39mSpirit Airlines

Wed 12/101:28 pmIND - CLT

1 stop5h 08mSpirit Airlines

Deal found 9/14

$164

Fri 10/31:48 pmCLT - IND

1 stop9h 23mSpirit Airlines

Sun 10/57:06 pmIND - CLT

Nonstop1h 45mSpirit Airlines

Deal found 9/14

$165

Mon 10/611:47 amCLT - IND

1 stop6h 38mMultiple Airlines

Tue 10/75:15 amIND - CLT

1 stop8h 20mMultiple Airlines

Deal found 9/15

$166

Thu 10/95:38 pmCLT - IND

Nonstop1h 43mSpirit Airlines

Sun 10/127:06 pmIND - CLT

Nonstop1h 45mSpirit Airlines

Deal found 9/15

$169

Fri 12/53:55 pmCLT - IND

Nonstop1h 39mSpirit Airlines

Sat 12/65:10 amIND - CLT

1 stop13h 26mSpirit Airlines

Deal found 9/16

$170

Tue 10/2111:14 amSAV - IND

1 stop5h 53mSpirit Airlines

Sat 10/258:55 amIND - SAV

1 stop25h 01mSpirit Airlines

Deal found 9/14

$173

Thu 11/1311:46 amMYR - IND

1 stop11h 10mSpirit Airlines

Sun 11/161:57 pmIND - MYR

1 stop5h 38mSpirit Airlines

Deal found 9/15

$173

Fri 10/38:51 pmCLT - IND

1 stop20h 35mMultiple Airlines

Mon 10/69:09 pmIND - CLT

1 stop10h 38mMultiple Airlines

Deal found 9/15

$175

Wed 11/1212:55 pmCLT - IND

2 stops10h 05mSouthwest

Sat 11/154:35 pmIND - CLT

1 stop4h 00mSouthwest

Deal found 9/14

$176

Best flights from South Carolina to Indianapolis
Discover carefully curated flight deals from South Carolina to Indianapolis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2025.

Wed 10/226:00 amCLT - IND

1 stop6h 05mSouthwest

Wed 10/221:10 pmIND - CLT

1 stop4h 25mSouthwest

Deal found 9/15

$171

Fri 11/1411:46 amMYR - IND

1 stop11h 10mSpirit Airlines

Sun 11/161:57 pmIND - MYR

1 stop5h 38mSpirit Airlines

Deal found 9/16

$173

Tue 10/146:00 amCLT - IND

1 stop3h 53mDelta

Sat 10/1810:33 amIND - CLT

1 stop5h 22mDelta

Deal found 9/14

$177

Fri 11/141:46 pmSAV - IND

1 stop9h 10mMultiple Airlines

Sun 11/161:28 pmIND - SAV

1 stop23h 20mMultiple Airlines

Deal found 9/14

$201

Sat 12/611:22 amCLT - IND

Nonstop1h 48mAmerican Airlines

Wed 12/104:40 pmIND - CLT

Nonstop1h 41mAmerican Airlines

Deal found 9/14

$212

Thu 10/99:53 pmGSP - IND

1 stop25h 45mAllegiant Air

Mon 10/208:00 amIND - GSP

1 stop12h 01mAllegiant Air

Deal found 9/16

$234

Tue 10/146:10 pmCLT - IND

1 stop4h 40mSouthwest

Tue 10/215:05 pmIND - CLT

1 stop3h 45mSouthwest

Deal found 9/14

$171

Tue 10/2111:14 amSAV - IND

1 stop5h 53mSpirit Airlines

Sat 10/258:55 amIND - SAV

1 stop25h 01mSpirit Airlines

Deal found 9/14

$173

Wed 12/36:00 amCLT - IND

1 stop5h 29mDelta

Sat 12/612:09 pmIND - CLT

1 stop4h 03mDelta

Deal found 9/14

$177

Wed 11/1212:55 pmCLT - IND

2 stops10h 05mSouthwest

Sat 11/154:35 pmIND - CLT

1 stop4h 00mSouthwest

Deal found 9/14

$176

Thu 11/133:05 pmCAE - IND

1 stop7h 51mMultiple Airlines

Sun 11/166:35 amIND - CAE

1 stop7h 40mMultiple Airlines

Deal found 9/15

$207

Sun 12/711:46 amMYR - IND

1 stop11h 10mSpirit Airlines

Mon 12/81:28 pmIND - MYR

1 stop6h 21mSpirit Airlines

Deal found 9/15

$192

Wed 12/310:26 amCLT - IND

Nonstop1h 45mAmerican Airlines

Tue 12/94:40 pmIND - CLT

Nonstop1h 41mAmerican Airlines

Deal found 9/16

$212

Wed 10/224:03 pmCAE - IND

1 stop5h 42mDelta

Wed 10/298:05 amIND - CAE

1 stop6h 13mDelta

Deal found 9/14

$197

Sat 11/13:40 pmSAV - IND

1 stop5h 30mMultiple Airlines

Fri 11/76:35 amIND - SAV

1 stop6h 42mMultiple Airlines

Deal found 9/16

$211

Tue 10/287:55 pmCHS - IND

1 stop21h 12mSpirit Airlines

Sun 11/28:16 pmIND - CHS

1 stop12h 45mSpirit Airlines

Deal found 9/14

$196

Tue 10/215:45 amCAE - IND

1 stop4h 48mDelta

Sat 10/256:00 amIND - CAE

1 stop6h 30mDelta

Deal found 9/14

$197

Wed 10/296:00 amCLT - IND

1 stop6h 05mSouthwest

Fri 10/312:50 pmIND - CLT

1 stop5h 10mSouthwest

Deal found 9/15

$211

Tue 11/411:14 amSAV - IND

1 stop5h 53mMultiple Airlines

Fri 11/76:35 amIND - SAV

1 stop6h 42mMultiple Airlines

Deal found 9/16

$211

Tue 10/215:45 amCAE - IND

1 stop4h 48mDelta

Wed 10/292:10 pmIND - CAE

1 stop7h 10mDelta

Deal found 9/14

$197

Tue 11/411:14 amSAV - IND

1 stop5h 53mSpirit Airlines

Sat 11/86:35 amIND - SAV

2 stops30h 13mSpirit Airlines

Deal found 9/16

$202

Fri 10/36:08 pmCHS - IND

2 stops23h 01mMultiple Airlines

Mon 10/66:05 pmIND - CHS

1 stop14h 32mMultiple Airlines

Deal found 9/13

$213

Wed 10/226:00 amCLT - IND

1 stop6h 05mSouthwest

Fri 10/242:50 pmIND - CLT

1 stop8h 30mSouthwest

Deal found 9/15

$216

Wed 10/226:00 amCAE - IND

1 stop7h 30mDelta

Tue 10/286:00 amIND - CAE

1 stop4h 16mDelta

Deal found 9/14

$197

Mon 1/268:34 pmGSP - IND

1 stop3h 34mAmerican Airlines

Fri 1/308:43 amIND - GSP

1 stop3h 23mAmerican Airlines

Deal found 9/15

$263

Thu 10/2310:51 amSAV - IND

1 stop7h 20mSpirit Airlines

Sun 10/265:15 amIND - SAV

1 stop28h 54mSpirit Airlines

Deal found 9/16

$204

Sat 2/2111:55 amCAE - IND

1 stop5h 07mDelta

Tue 2/243:00 pmIND - CAE

1 stop6h 29mDelta

Deal found 9/13

$197

Mon 10/138:04 pmGSP - IND

1 stop4h 05mAmerican Airlines

Wed 10/1512:06 pmIND - GSP

1 stop5h 16mAmerican Airlines

Deal found 9/15

$270

Sat 11/13:40 pmSAV - IND

1 stop5h 30mSpirit Airlines

Sat 11/85:10 amIND - SAV

1 stop7h 38mSpirit Airlines

Deal found 9/16

$207

Wed 10/155:20 pmCHS - IND

2 stops24h 15mMultiple Airlines

Tue 10/215:15 amIND - CHS

1 stop13h 26mMultiple Airlines

Deal found 9/14

$239

Last-minute flights from South Carolina to Indianapolis
Discover last-minute flight deals from South Carolina to Indianapolis. Data last updated September 16, 2025 and is based on user searches.

Thu 9/257:55 pmCLT - IND

1 stop13h 52mMultiple Airlines

Fri 9/265:06 pmIND - CLT

1 stop5h 53mMultiple Airlines

Deal found 9/15

$176

Fri 10/38:51 pmCLT - IND

1 stop20h 35mMultiple Airlines

Sun 10/57:06 pmIND - CLT

Nonstop1h 45mMultiple Airlines

Deal found 9/14

$163

Fri 10/31:48 pmCLT - IND

1 stop9h 23mSpirit Airlines

Sun 10/57:06 pmIND - CLT

Nonstop1h 45mSpirit Airlines

Deal found 9/14

$165

Fri 10/38:51 pmCLT - IND

1 stop20h 35mMultiple Airlines

Mon 10/69:09 pmIND - CLT

1 stop10h 38mMultiple Airlines

Deal found 9/15

$175

Fri 10/31:48 pmCLT - IND

1 stop9h 23mSpirit Airlines

Mon 10/69:09 pmIND - CLT

1 stop10h 38mSpirit Airlines

Deal found 9/14

$178

Mon 10/611:47 amCLT - IND

1 stop6h 38mMultiple Airlines

Tue 10/75:15 amIND - CLT

1 stop8h 20mMultiple Airlines

Deal found 9/15

$166

Wed 10/89:57 pmCLT - IND

Nonstop1h 47mAmerican Airlines

Wed 10/152:43 pmIND - CLT

Nonstop1h 46mAmerican Airlines

Deal found 9/14

$161

Thu 10/95:38 pmCLT - IND

Nonstop1h 43mSpirit Airlines

Sun 10/127:06 pmIND - CLT

Nonstop1h 45mSpirit Airlines

Deal found 9/15

$169

Thu 10/169:46 pmCLT - IND

1 stop12h 02mSpirit Airlines

Sun 10/197:06 pmIND - CLT

Nonstop1h 45mSpirit Airlines

Deal found 9/15

$177

Tue 10/2111:14 amSAV - IND

1 stop5h 53mSpirit Airlines

Sat 10/258:55 amIND - SAV

1 stop25h 01mSpirit Airlines

Deal found 9/14

$173

Fri 10/2412:05 pmCLT - IND

1 stop9h 23mFrontier

Sun 10/2610:06 pmIND - CLT

1 stop9h 54mFrontier

Deal found 9/13

$179

Mon 10/279:10 pmCHS - IND

1 stop19h 57mSpirit Airlines

Wed 11/56:35 amIND - CHS

1 stop28h 10mSpirit Airlines

Deal found 9/15

$179

One-way flights from South Carolina to Indianapolis
Search for one-way flight options from South Carolina to Indianapolis. Find affordable one-way fares based on user searches. Data last updated September 16, 2025.

Mon 9/2911:47 amCLT - IND

1 stop6h 38mFrontier

Deal found 9/15

$71

Fri 11/1411:37 amCLT - IND

1 stop6h 27mFrontier

Deal found 9/14

$72

Wed 10/158:52 amCLT - IND

1 stop8h 15mSpirit Airlines

Deal found 9/16

$74

Thu 10/165:38 pmCLT - IND

Nonstop1h 43mSpirit Airlines

Deal found 9/13

$75

Thu 10/305:38 pmCLT - IND

Nonstop1h 43mSpirit Airlines

Deal found 9/15

$76

Mon 11/179:57 amCLT - IND

1 stop11h 22mFrontier

Deal found 9/15

$78

Thu 11/135:40 pmCHS - IND

1 stop5h 16mSpirit Airlines

Deal found 9/14

$79

Fri 12/123:55 pmCLT - IND

Nonstop1h 39mSpirit Airlines

Deal found 9/14

$80

Fri 10/31:48 pmCLT - IND

1 stop9h 23mSpirit Airlines

Deal found 9/14

$81

Fri 10/32:01 pmCLT - IND

1 stop27h 25mFrontier

Deal found 9/13

$83

Sat 10/114:00 pmCLT - IND

1 stop16h 44mFrontier

Deal found 9/13

$85

Tue 10/146:10 pmCLT - IND

1 stop4h 40mSouthwest

Deal found 9/13

$86

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to Indianapolis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

CharlotteIndianapolis

CLT - IND

CLTIND

Charlotte Douglas

Wed 10/22

6:00 am-12:05 pm

1 stop6h 05m

Indianapolis

Wed 10/22

1:10 pm-5:35 pm

1 stop4h 25m

$171

CharlotteIndianapolis

CLT - IND

CLTIND

Charlotte Douglas

Tue 10/14

6:10 pm-10:50 pm

1 stop4h 40m

Indianapolis

Tue 10/21

5:05 pm-8:50 pm

1 stop3h 45m

$171

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Fri 11/14

11:46 am-10:56 pm

1 stop11h 10m

Indianapolis

Sun 11/16

1:57 pm-7:35 pm

1 stop5h 38m

$173

SavannahIndianapolis

SAV - IND

SAVIND

Savannah/Hilton Head

Tue 10/21

11:14 am-5:07 pm

1 stop5h 53m

Indianapolis

Sat 10/25

8:55 am-9:56 am

1 stop25h 01m

$173

CharlotteIndianapolis

CLT - IND

CLTIND

Charlotte Douglas

Wed 11/12

12:55 pm-11:00 pm

2 stops10h 05m

Indianapolis

Sat 11/15

4:35 pm-8:35 pm

1 stop4h 00m

$176

CharlotteIndianapolis

CLT - IND

CLTIND

Charlotte Douglas

Tue 10/14

6:00 am-9:53 am

1 stop3h 53m

Indianapolis

Sat 10/18

10:33 am-3:55 pm

1 stop5h 22m

$177

CharlotteIndianapolis

CLT - IND

CLTIND

Charlotte Douglas

Wed 12/3

6:00 am-11:29 am

1 stop5h 29m

Indianapolis

Sat 12/6

12:09 pm-4:12 pm

1 stop4h 03m

$177

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Sun 12/7

11:46 am-10:56 pm

1 stop11h 10m

Indianapolis

Mon 12/8

1:28 pm-7:49 pm

1 stop6h 21m

$192

CharlestonIndianapolis

CHS - IND

CHSIND

Charleston

Tue 10/28

7:55 pm-5:07 pm

1 stop21h 12m

Indianapolis

Sun 11/2

8:16 pm-9:01 am

1 stop12h 45m

$196

ColumbiaIndianapolis

CAE - IND

CAEIND

Columbia Metropolitan

Wed 10/22

4:03 pm-9:45 pm

1 stop5h 42m

Indianapolis

Wed 10/29

8:05 am-2:18 pm

1 stop6h 13m

$197

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 60 results

...

Best time to book a flight from South Carolina to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from South Carolina with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Indianapolis

What is the cheapest month to book a flight from South Carolina to Indianapolis?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Indianapolis (average of $286). Flying from South Carolina to Indianapolis in March is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IND?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Indianapolis as you normally would.

Related info for your journey

What airport do you fly into for flights to Indianapolis from South Carolina?
Indianapolis (IND) is the airport you will fly into if you book a flight from South Carolina to Indianapolis. It is only a 8.3 mi journey from Indianapolis (IND) to Indianapolis’s city center.
How popular is this South Carolina to Indianapolis flight route?
The South Carolina to Indianapolis flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from South Carolina to Indianapolis?
A quick flight from South Carolina to Indianapolis can take about 3h 53m. Southwest provides one of the quickest options available for as low as $177. The distance between South Carolina and Indianapolis is about 427 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines to fly from South Carolina to Indianapolis one-way?
The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $74. However, be on the lookout for offers from Frontier and Delta, as they are both options that can get you from South Carolina to Indianapolis for a low price.
What are the most popular routes from South Carolina to Indianapolis?
When deciding which route to take from South Carolina to Indianapolis consider Charlotte Douglas - Indianapolis, Columbia Metropolitan - Indianapolis or Greenville - Indianapolis as they are the most popular.
Can I find deals for flights from South Carolina to Indianapolis that include hotel bookings?
Yes. In addition to deals on South Carolina to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from South Carolina to Indianapolis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Indianapolis.
Can I find deals for business class flights from South Carolina to Indianapolis?
Yes. Cheapflights offers flight deals from South Carolina to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from South Carolina to Indianapolis?
Currently, August is the cheapest month in which you can book a flight from South Carolina to Indianapolis (average of $286). Flying from South Carolina to Indianapolis in March is currently the most expensive (average of $360). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Muncie

Terre Haute

Noblesville

Fishers

Anderson

Kokomo

Greenwood

Bloomington

Franklin

Plainfield

Carmel

Crawfordsville

Speedway

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Top 6 airlines flying from South Carolina to Indianapolis

Airline	Cheapest	Average	Flexibility	On-time
Allegiant Air	Cheapest$45	Average$133	FlexibilityNo cancel fee	On-time88%
Spirit Airlines	Cheapest$149	Average$251	FlexibilityNo cancel fee	On-time65%
Southwest	Cheapest$189	Average$374	FlexibilityNo cancel fee	On-time63%
United Airlines	Cheapest$190	Average$435	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$212	Average$368	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$228	Average$383	FlexibilityNo cancel fee	On-time71%

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$71+ Cheap flights from South Carolina to Indianapolis (IND)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/29. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from South Carolina to Indianapolis with Cheapflights

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Cheap flight deals from South Carolina to Indianapolis

Keep the following information in mind while searching for South Carolina to Indianapolis flight deals. Data was last updated September 16, 2025.

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good one-way deal

Find flight deals from South Carolina to Indianapolis

Cheapest flights from South Carolina to IndianapolisExplore the most affordable flight options available from South Carolina to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

Explore the most affordable flight options available from South Carolina to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from South Carolina to Indianapolis that are best for you.

Best time to book a flight from South Carolina to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from South Carolina with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Indianapolis

What is the cheapest month to book a flight from South Carolina to Indianapolis?

What is the cheapest time of day to fly from SC to IND?

Find hourly flight availability from South Carolina to Indianapolis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Indianapolis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly into for flights to Indianapolis from South Carolina?

How popular is this South Carolina to Indianapolis flight route?

How long is the flight from South Carolina to Indianapolis?

What are the cheapest airlines to fly from South Carolina to Indianapolis one-way?

What are the most popular routes from South Carolina to Indianapolis?

Can I find deals for flights from South Carolina to Indianapolis that include hotel bookings?

How can I find direct flights from South Carolina to Indianapolis?

Can I find deals for business class flights from South Carolina to Indianapolis?

What is the cheapest month to book a flight from South Carolina to Indianapolis?

Traveling to a place near Indianapolis?

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Alternative routes for South Carolina to Indianapolis

See prices for flight routes from nearby airports that may be better suited for you.

Top 6 airlines flying from South Carolina to Indianapolis

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Cheapest flights from South Carolina to Indianapolis
Explore the most affordable flight options available from South Carolina to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.