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$50+ Cheap flights from South Carolina to Indianapolis (IND)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/28. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — IND
Mar 6 — Mar 131
Fri 3/6
Fri 3/13
1 adult, Economy
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Cheap flight deals from South Carolina to Indianapolis

Cheapest flights from South Carolina to Indianapolis
Explore the most affordable flight options available from South Carolina to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.

This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:50 pm
SAV
-
IND
Nonstop1h 51m
Allegiant Air
Mon 3/96:14 pm
IND
-
SAV
Nonstop1h 46m
Allegiant Air
Deal found 2/3$95
This Expedia deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/242:46 pm
CLT
-
IND
1 stop5h 42m
Multiple Airlines
Thu 2/266:00 am
IND
-
CLT
1 stop8h 17m
Multiple Airlines
Deal found 2/2$111
This Expedia deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/91:24 pm
CLT
-
IND
1 stop9h 24m
Spirit Airlines
Wed 3/116:00 am
IND
-
CLT
1 stop7h 43m
Spirit Airlines
Deal found 1/31$112
This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:00 pm
CHS
-
IND
1 stop6h 25m
Spirit Airlines
Tue 3/106:00 am
IND
-
CHS
1 stop10h 05m
Spirit Airlines
Deal found 2/3$117
This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/68:50 pm
SAV
-
IND
Nonstop1h 51m
Multiple Airlines
Mon 3/96:00 am
IND
-
SAV
1 stop5h 32m
Multiple Airlines
Deal found 2/3$123
This CheapOair deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/45:00 pm
CHS
-
IND
1 stop6h 25m
Spirit Airlines
Mon 3/96:00 am
IND
-
CHS
1 stop10h 05m
Spirit Airlines
Deal found 2/3$126
This Expedia deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2310:42 pm
CLT
-
IND
1 stop21h 46m
Multiple Airlines
Thu 2/266:00 am
IND
-
CLT
1 stop8h 17m
Multiple Airlines
Deal found 2/2$127
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/279:21 am
CLT
-
IND
1 stop14h 04m
Spirit Airlines
Mon 3/26:00 am
IND
-
CLT
1 stop8h 17m
Spirit Airlines
Deal found 2/2$136
This Mytrip deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/612:27 pm
SAV
-
IND
1 stop10h 58m
Spirit Airlines
Mon 3/96:00 am
IND
-
SAV
1 stop5h 32m
Spirit Airlines
Deal found 2/3$141
This CheapOair deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/279:21 am
CLT
-
IND
1 stop14h 04m
Spirit Airlines
Sun 3/16:00 am
IND
-
CLT
1 stop17h 59m
Spirit Airlines
Deal found 2/3$142
This Mytrip deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/410:09 am
MYR
-
IND
1 stop13h 16m
Spirit Airlines
Wed 3/116:00 am
IND
-
MYR
1 stop8h 55m
Spirit Airlines
Deal found 2/2$142
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/65:00 pm
CHS
-
IND
1 stop6h 25m
Spirit Airlines
Tue 3/103:12 pm
IND
-
CHS
2 stops24h 53m
Spirit Airlines
Deal found 2/2$150

Find flight deals from South Carolina to Indianapolis

Keep the following information in mind while searching for South Carolina to Indianapolis flight deals. Data was last updated February 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$95
(Mytrip)

One-way from

$50
(Travelocity)

Popular in

March

Cheapest in

August

Average price

$319

Good one-way deal

$119 or less
Provider with most accurate pricing for Myrtle Beach Intl-Indianapolis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-Indianapolis flights.
Search Deals
From South Carolina to Indianapolis
Search Deals
One-way flight from South Carolina to Indianapolis
Search Deals
Highest demand for flights based on searches. 24% potential increase in price ($125 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 9% potential price decrease ($34 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals
Price to beat on a one-way flight from South Carolina to Indianapolis.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from South Carolina to Indianapolis that are best for you.

Fly from

South Carolina

Fly to

Indianapolis

Route

Depart

Return

Price

SavannahIndianapolis

SAV - IND

SAVIND

Savannah/Hilton Head

Fri 3/6

8:50 pm-10:41 pm

Nonstop1h 51m

Indianapolis

Mon 3/9

6:00 am-11:32 am

1 stop5h 32m

$123

CharlestonIndianapolis

CHS - IND

CHSIND

Charleston

Wed 3/4

5:00 pm-11:25 pm

1 stop6h 25m

Indianapolis

Mon 3/9

6:00 am-4:05 pm

1 stop10h 05m

$126

SavannahIndianapolis

SAV - IND

SAVIND

Savannah/Hilton Head

Fri 3/6

12:27 pm-11:25 pm

1 stop10h 58m

Indianapolis

Mon 3/9

6:00 am-11:32 am

1 stop5h 32m

$141

SavannahIndianapolis

SAV - IND

SAVIND

Savannah/Hilton Head

Fri 3/13

7:30 am-9:21 am

Nonstop1h 51m

Indianapolis

Mon 3/16

10:11 am-11:57 am

Nonstop1h 46m

$158

CharlotteIndianapolis

CLT - IND

CLTIND

Charlotte Douglas

Wed 2/18

8:43 am-8:32 am

1 stop23h 49m

Indianapolis

Mon 2/23

6:10 pm-1:51 pm

1 stop19h 41m

$158

SavannahIndianapolis

SAV - IND

SAVIND

Savannah/Hilton Head

Fri 3/13

7:30 am-9:21 am

Nonstop1h 51m

Indianapolis

Mon 3/16

6:00 am-3:55 pm

1 stop9h 55m

$162

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Mon 3/2

3:59 pm-11:25 pm

1 stop7h 26m

Indianapolis

Fri 3/6

6:00 am-8:58 am

1 stop26h 58m

$163

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Thu 3/5

9:09 am-7:23 pm

1 stop10h 14m

Indianapolis

Sun 3/8

8:18 pm-8:13 am

1 stop11h 55m

$174

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Mon 3/16

6:28 pm-10:32 pm

1 stop28h 04m

Indianapolis

Wed 3/18

6:00 am-2:32 pm

1 stop8h 32m

$179

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Fri 2/27

10:09 am-11:25 pm

1 stop13h 16m

Indianapolis

Tue 3/3

3:12 pm-2:55 pm

2 stops23h 43m

$180

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/2

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Best time to book a flight from South Carolina to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Indianapolis

What is the cheapest month to book a flight from South Carolina to Indianapolis?

Currently, October is the cheapest month in which you can book a flight from South Carolina to Indianapolis (average of $40). Flying from South Carolina to Indianapolis in January is currently the most expensive (average of $98). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IND?

Find hourly flight availability from South Carolina to Indianapolis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 4, 2026.

A simple way to save on the total cost of your ticket is to fly from South Carolina to Indianapolis in the afternoon. If you’re flexible enough to do this you can expect to save up to 80% on your trip compared to booking a flight at noon.

What is the cheapest day to fly from South Carolina to Indianapolis?

Use this chart to determine the cheapest time to fly round-trip from South Carolina to Indianapolis. Price data was last updated on February 2, 2025.

Travelers seeking maximum savings on their South Carolina to Indianapolis flight should consider departing on Monday afternoons when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from South Carolina to Indianapolis?

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Indianapolis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Indianapolis from South Carolina?

    Indianapolis (IND) is the airport you will fly into if you book a flight from South Carolina to Indianapolis. It is only a 8.3 mi journey from Indianapolis (IND) to Indianapolis’s city center.

  • How popular is this South Carolina to Indianapolis flight route?

    The South Carolina to Indianapolis flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from South Carolina to Indianapolis?

    A quick flight from South Carolina to Indianapolis can take about 1h 51m. Spirit Airlines provides one of the quickest options available for as low as $158. The distance between South Carolina and Indianapolis is about 596 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from South Carolina to Indianapolis one-way?

    The cheapest airline one-way is Spirit Airlines, with whom users have recently found tickets for as low as $150. However, be on the lookout for offers from Delta and Frontier, as they are both options that can get you from South Carolina to Indianapolis for a low price.

  • What are the most popular routes from South Carolina to Indianapolis?

    When deciding which route to take from South Carolina to Indianapolis consider Charlotte Douglas - Indianapolis, Charleston - Indianapolis or Columbia Metropolitan - Indianapolis as they are the most popular.

  • Can I find deals for flights from South Carolina to Indianapolis that include hotel bookings?

    Yes. In addition to deals on South Carolina to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Indianapolis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Indianapolis.

  • Can I find deals for business class flights from South Carolina to Indianapolis?

    Yes. Cheapflights offers flight deals from South Carolina to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Indianapolis?

    Currently, October is the cheapest month in which you can book a flight from South Carolina to Indianapolis (average of $40). Flying from South Carolina to Indianapolis in January is currently the most expensive (average of $98). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Indianapolis?

Book flights to Indianapolis if you plan to visit one of these locations
Muncie
Terre Haute
Fishers
Noblesville
Greenwood
Plainfield
Anderson
Kokomo
Mooresville
Franklin
Carmel
Crawfordsville
Bloomington

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Alternative routes for South Carolina to Indianapolis

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from South Carolina to Indianapolis

Discover the top 6 airlines that operate flights from South Carolina to Indianapolis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$45Average$126FlexibilityNo cancel feeOn-time88%
Spirit AirlinesCheapest$83Average$201FlexibilityNo cancel feeOn-time65%
SouthwestCheapest$189Average$388FlexibilityNo cancel feeOn-time63%
United AirlinesCheapest$190Average$331FlexibilityNo cancel feeOn-time69%
DeltaCheapest$208Average$362FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$228Average$397FlexibilityNo cancel feeOn-time71%

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