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$45+ Cheap flights from South Carolina to Indianapolis (IND)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/30. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — IND
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from South Carolina to Indianapolis

Keep the following information in mind while searching for South Carolina to Indianapolis flight deals. Data was last updated May 1, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$103
(Mytrip)

One-way from

$45
(Mytrip)

Popular in

March

Cheapest in

August

Average price

$287

Good round-trip deal

$81 or less
Provider with most accurate pricing for Myrtle Beach Intl-Indianapolis flight deals.
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Provider most trusted by Cheapflights users for Myrtle Beach Intl-Indianapolis flights.
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From South Carolina to Indianapolis
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One-way flight from South Carolina to Indianapolis
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Highest demand for flights based on searches. 34% potential increase in price ($194 potential increase over avg. RT price).
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Cheapest flight prices on average. 10% potential price decrease ($36 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Price to beat on a round-trip flight from South Carolina to Indianapolis.
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Find flight deals from South Carolina to Indianapolis

Cheapest flights from South Carolina to Indianapolis
Explore the most affordable flight options available from South Carolina to Indianapolis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Mytrip deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/135:18 pmCHS - IND
Nonstop1h 50mAllegiant Air
Mon 6/2312:30 pmIND - CHS
Nonstop1h 44mAllegiant Air
Deal found 4/29$103
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/149:51 pmMYR - IND
Nonstop1h 44mAllegiant Air
Sat 6/217:21 pmIND - MYR
Nonstop1h 40mAllegiant Air
Deal found 4/30$106
This Booking.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/248:58 pmMYR - IND
Nonstop1h 47mMultiple Airlines
Mon 5/265:45 amIND - MYR
1 stop5h 14mMultiple Airlines
Deal found 4/29$111
This Booking.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/306:40 pmCHS - IND
Nonstop1h 52mMultiple Airlines
Mon 6/212:05 pmIND - CHS
1 stop10h 04mMultiple Airlines
Deal found 4/29$118
This Priceline deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/145:32 pmMYR - IND
1 stop5h 43mSpirit Airlines
Sun 5/185:45 amIND - MYR
1 stop5h 14mSpirit Airlines
Deal found 4/28$148
This Cheapflightsfares deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/306:34 pmCLT - IND
1 stop5h 25mSpirit Airlines
Sun 6/19:14 pmIND - CLT
Nonstop1h 45mSpirit Airlines
Deal found 4/30$157
This Cheapflightsfares deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/296:00 amCHS - IND
1 stop5h 10mSpirit Airlines
Mon 6/212:05 pmIND - CHS
1 stop10h 04mSpirit Airlines
Deal found 4/29$163
This Frontier deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/1510:36 pmCLT - IND
1 stop11h 05mFrontier
Sun 5/189:18 amIND - CLT
1 stop7h 21mFrontier
Deal found 4/29$180
This Priceline deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/156:38 pmCLT - IND
Nonstop1h 41mMultiple Airlines
Sun 5/189:18 amIND - CLT
1 stop7h 21mMultiple Airlines
Deal found 4/29$182
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/56:05 amCAE - IND
1 stop5h 09mDelta
Tue 6/108:00 amIND - CAE
1 stop7h 48mDelta
Deal found 4/28$213
This Mytrip deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/149:06 amSAV - IND
Nonstop1h 46mAllegiant Air
Sat 6/286:30 amIND - SAV
Nonstop1h 46mAllegiant Air
Deal found 4/30$214
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/75:59 pmAGS - IND
1 stop5h 03mDelta
Tue 6/106:00 amIND - AGS
1 stop3h 20mDelta
Deal found 4/30$227

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Indianapolis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from South Carolina to Indianapolis that are best for you.

Fly from

South Carolina

Fly to

Indianapolis

Route

Depart

Return

Price

CharlestonIndianapolis

CHS - IND

CHSIND

Charleston

Fri 6/13

5:18 pm-7:08 pm

Nonstop1h 50m

Indianapolis

Mon 6/23

12:30 pm-2:14 pm

Nonstop1h 44m

$103

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Sat 6/14

9:51 pm-11:35 pm

Nonstop1h 44m

Indianapolis

Sat 6/21

7:21 pm-9:01 pm

Nonstop1h 40m

$106

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Sat 5/24

8:58 pm-10:45 pm

Nonstop1h 47m

Indianapolis

Mon 5/26

5:45 am-10:59 am

1 stop5h 14m

$111

CharlestonIndianapolis

CHS - IND

CHSIND

Charleston

Fri 5/30

6:40 pm-8:32 pm

Nonstop1h 52m

Indianapolis

Mon 6/2

12:05 pm-10:09 pm

1 stop10h 04m

$118

Myrtle BeachIndianapolis

MYR - IND

MYRIND

Myrtle Beach Intl

Wed 5/14

5:32 pm-11:15 pm

1 stop5h 43m

Indianapolis

Sun 5/18

5:45 am-10:59 am

1 stop5h 14m

$148

CharlotteIndianapolis

CLT - IND

CLTIND

Charlotte Douglas

Fri 5/30

6:34 pm-11:59 pm

1 stop5h 25m

Indianapolis

Sun 6/1

9:14 pm-10:59 pm

Nonstop1h 45m

$157

CharlestonIndianapolis

CHS - IND

CHSIND

Charleston

Thu 5/29

6:00 am-11:10 am

1 stop5h 10m

Indianapolis

Mon 6/2

12:05 pm-10:09 pm

1 stop10h 04m

$163

CharlotteIndianapolis

CLT - IND

CLTIND

Charlotte Douglas

Thu 5/15

10:36 pm-9:41 am

1 stop11h 05m

Indianapolis

Sun 5/18

9:18 am-4:39 pm

1 stop7h 21m

$180

CharlotteIndianapolis

CLT - IND

CLTIND

Charlotte Douglas

Thu 5/15

6:38 pm-8:19 pm

Nonstop1h 41m

Indianapolis

Sun 5/18

9:18 am-4:39 pm

1 stop7h 21m

$182

ColumbiaIndianapolis

CAE - IND

CAEIND

Columbia Metropolitan

Thu 6/5

6:05 am-11:14 am

1 stop5h 09m

Indianapolis

Tue 6/10

8:00 am-3:48 pm

1 stop7h 48m

$213

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Showing 1-10 of 60 results
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Best time to book a flight from South Carolina to Indianapolis

Have a flexible travel schedule? Discover the best time to fly to Indianapolis from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Indianapolis

What is the cheapest month to book a flight from South Carolina to Indianapolis?

Currently, August is the cheapest month in which you can book a flight from South Carolina to Indianapolis (average of $297). Flying from South Carolina to Indianapolis in March is currently the most expensive (average of $361). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to IND?

Find hourly flight availability from South Carolina to Indianapolis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from South Carolina to Indianapolis as you normally would.

Rainfall in Indianapolis by month

Plan your trip to Indianapolis by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Indianapolis ranges from 2.3 - 5.1 inches per month. May is typically the wettest month, when rainfall can reach 5.1 in. February is typically the driest time to visit Indianapolis when rainfall is around 2.3 in.

Temperature in Indianapolis by month

Plan your trip to Indianapolis by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Indianapolis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 75.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 28.4 F).

Reviews of airlines servicing Indianapolis

Get insights into the airlines that provide service to Indianapolis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indianapolis. Reviews last updated May 1, 2025.
Read through reviews of airlines operating flights from South Carolina to Indianapolis, such as Southwest, Delta and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,294 reviews

Overall

8.0

Entertainment

7.6

Crew

8.6

Boarding

8.2

Food

7.1

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Southwest
8.0
Very good
4,294 reviews
Southwest
8.0
Very good
4,294 reviews

Overall

8.0

Entertainment

7.6

Crew

8.6

Boarding

8.2

Food

7.1

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Delta
8.0
Very good
7,934 reviews
Southwest
8.0
Very good
4,294 reviews

Overall

8.0

Entertainment

7.6

Crew

8.6

Boarding

8.2

Food

7.1

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
United Airlines
7.4
Good
8,696 reviews
Southwest
8.0
Very good
4,294 reviews

Overall

8.0

Entertainment

7.6

Crew

8.6

Boarding

8.2

Food

7.1

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
Allegiant Air
7.3
Good
734 reviews
Southwest
8.0
Very good
4,294 reviews

Overall

8.0

Entertainment

7.6

Crew

8.6

Boarding

8.2

Food

7.1

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,294 reviews

Overall

8.0

Entertainment

7.6

Crew

8.6

Boarding

8.2

Food

7.1

Comfort

8.0

Reviews

1 / 20
10.0
Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Indianapolis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Indianapolis from South Carolina?

    Indianapolis (IND) is the airport you will fly into if you book a flight from South Carolina to Indianapolis. It is only a 8.3 mi journey from Indianapolis (IND) to Indianapolis’s city center.

  • How popular is this South Carolina to Indianapolis flight route?

    The South Carolina to Indianapolis flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from South Carolina to Indianapolis one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $45. However, be on the lookout for offers from Spirit Airlines and Frontier, as they are both options that can get you from South Carolina to Indianapolis for a low price.

  • What are the most popular routes from South Carolina to Indianapolis?

    When deciding which route to take from South Carolina to Indianapolis consider Charlotte Douglas - Indianapolis, Myrtle Beach Intl - Indianapolis or Columbia Metropolitan - Indianapolis as they are the most popular.

  • What are the cheapest flights from South Carolina to Indianapolis?

    Looking at all options, your cheapest flight can be booked for $58. While the most popular route (Charlotte Douglas - Indianapolis) can be booked for $159 on average our data indicates $123 when flying from South Carolina to Indianapolis.

  • Can I find deals for flights from South Carolina to Indianapolis that include hotel bookings?

    Yes. In addition to deals on South Carolina to Indianapolis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Indianapolis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Indianapolis.

  • Can I find deals for business class flights from South Carolina to Indianapolis?

    Yes. Cheapflights offers flight deals from South Carolina to Indianapolis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Indianapolis?

    Currently, August is the cheapest month in which you can book a flight from South Carolina to Indianapolis (average of $297). Flying from South Carolina to Indianapolis in March is currently the most expensive (average of $361). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near South Carolina?

Book flights to South Carolina if you plan to visit one of these locations
Greenwood
Bloomington
Terre Haute
Noblesville
Muncie
Fishers
Anderson
Carmel
Kokomo
Franklin
Plainfield
Crawfordsville
Shelbyville
Speedway

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for South Carolina to Indianapolis

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from South Carolina to Indianapolis

Discover the top 6 airlines that operate flights from South Carolina to Indianapolis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$67Average$136FlexibilityNo cancel feeOn-time88%
Spirit AirlinesCheapest$115Average$235FlexibilityNo cancel feeOn-time65%
DeltaCheapest$218Average$346FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$228Average$428FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$228Average$378FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$286Average$402FlexibilityNo cancel feeOn-time63%

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