$45+ Cheap flights from Indianapolis (IND) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/8. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
May 30 — Jun 61
Round-trip
1 adult, Economy
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Find cheap flights from Indianapolis to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Indianapolis to South CarolinaExplore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2026.
Explore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:47 pm
IND
- CHS
Nonstop1h 48m
Allegiant Air
Mon 6/159:30 pm
CHS
- IND
Nonstop1h 56m
Allegiant Air
Deal found 4/25![Allegiant Air logo]()
$91
This Cheapflightsfares deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:47 pm
IND
- CHS
Nonstop1h 48m
Allegiant Air
Fri 6/129:30 pm
CHS
- IND
Nonstop1h 56m
Allegiant Air
Deal found 4/29![Allegiant Air logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:51 pm
IND
- CHS
Nonstop1h 50m
Allegiant Air
Fri 7/179:31 pm
CHS
- IND
Nonstop1h 54m
Allegiant Air
Deal found 4/27![Allegiant Air logo]()
$96
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/811:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Fri 5/158:30 am
SAV
- IND
Nonstop1h 51m
Allegiant Air
Deal found 4/27![Allegiant Air logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/811:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Mon 5/118:30 am
SAV
- IND
Nonstop1h 51m
Allegiant Air
Deal found 4/26![Allegiant Air logo]()
$100
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:51 pm
IND
- CHS
Nonstop1h 50m
Allegiant Air
Mon 7/279:31 pm
CHS
- IND
Nonstop1h 54m
Allegiant Air
Deal found 4/25![Allegiant Air logo]()
$103
This Cheapflightsfares deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1811:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Mon 5/258:46 pm
SAV
- IND
Nonstop1h 55m
Allegiant Air
Deal found 4/30![Allegiant Air logo]()
$108
This Cheapflightsfares deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1111:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Fri 5/158:30 am
SAV
- IND
Nonstop1h 51m
Allegiant Air
Deal found 4/26![Allegiant Air logo]()
$109
This Cheapflightsfares deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:52 pm
IND
- CHS
Nonstop1h 48m
Allegiant Air
Mon 6/229:30 pm
CHS
- IND
Nonstop1h 56m
Allegiant Air
Deal found 4/29![Allegiant Air logo]()
$112
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:51 pm
IND
- CHS
Nonstop1h 50m
Allegiant Air
Fri 7/179:31 pm
CHS
- IND
Nonstop1h 54m
Allegiant Air
Deal found 4/27![Allegiant Air logo]()
$119
This Cheapflightsfares deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Mon 5/118:30 am
SAV
- IND
Nonstop1h 51m
Allegiant Air
Deal found 4/28![Allegiant Air logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:15 pm
IND
- CHS
Nonstop1h 49m
Allegiant Air
Fri 6/59:25 pm
CHS
- IND
Nonstop1h 56m
Allegiant Air
Deal found 4/28![Allegiant Air logo]()
$123
Best flights from Indianapolis to South CarolinaDiscover carefully curated flight deals from Indianapolis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 30, 2026.
Discover carefully curated flight deals from Indianapolis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 30, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:51 pm
IND
- CHS
Nonstop1h 50m
Allegiant Air
Mon 7/279:31 pm
CHS
- IND
Nonstop1h 54m
Allegiant Air
Deal found 4/29![Allegiant Air logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/56:47 pm
IND
- CHS
Nonstop1h 48m
Multiple Airlines
Mon 6/89:28 pm
CHS
- IND
2 stops37h 51m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$258
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:16 am
IND
- CAE
1 stop3h 55m
Delta
Wed 6/35:40 am
CAE
- IND
1 stop4h 34m
Delta
Deal found 4/29![Delta logo]()
$260
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/277:05 am
IND
- CAE
2 stops7h 11m
United Airlines
Wed 6/32:29 pm
CAE
- IND
1 stop4h 32m
United Airlines
Deal found 4/29![United Airlines logo]()
$282
This American Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/158:08 pm
IND
- AGS
1 stop3h 50m
American Airlines
Mon 5/188:23 pm
AGS
- IND
1 stop3h 46m
American Airlines
Deal found 4/27![American Airlines logo]()
$302
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:10 pm
IND
- CHS
1 stop3h 55m
Southwest
Sun 6/78:05 pm
CHS
- IND
1 stop4h 40m
Southwest
Deal found 4/29![Southwest logo]()
$329
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/188:05 am
IND
- CAE
1 stop4h 57m
Delta
Tue 6/307:01 am
CAE
- IND
1 stop7h 05m
Delta
Deal found 4/27![Delta logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/107:00 am
IND
- GSP
1 stop7h 25m
Allegiant Air
Sun 7/123:51 pm
GSP
- IND
1 stop20h 33m
Allegiant Air
Deal found 4/30![Allegiant Air logo]()
$287
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/241:41 pm
IND
- AGS
1 stop6h 08m
Delta
Wed 7/297:23 pm
AGS
- IND
1 stop5h 18m
Delta
Deal found 4/25![Delta logo]()
$277
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:35 am
IND
- SAV
1 stop5h 17m
United Airlines
Wed 6/33:24 pm
SAV
- IND
2 stops8h 35m
United Airlines
Deal found 4/27![United Airlines logo]()
$305
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/125:16 pm
IND
- CAE
1 stop5h 54m
American Airlines
Mon 6/158:30 pm
CAE
- IND
1 stop3h 36m
American Airlines
Deal found 4/26![American Airlines logo]()
$309
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1712:30 pm
IND
- GSP
2 stops6h 30m
Southwest
Sun 6/217:30 pm
GSP
- IND
1 stop3h 30m
Southwest
Deal found 4/27![Southwest logo]()
$332
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:00 am
IND
- CHS
1 stop6h 10m
Delta
Thu 5/286:03 pm
CHS
- IND
1 stop5h 23m
Delta
Deal found 4/27![Delta logo]()
$278
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/38:00 am
IND
- HHH
1 stop6h 21m
United Airlines
Tue 6/91:45 pm
HHH
- IND
1 stop8h 30m
United Airlines
Deal found 4/29![United Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1310:31 am
IND
- AGS
1 stop4h 07m
American Airlines
Sun 5/178:23 pm
AGS
- IND
1 stop3h 46m
American Airlines
Deal found 4/28![American Airlines logo]()
$317
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1512:15 pm
IND
- CHS
2 stops8h 55m
Southwest
Sat 9/1911:00 am
CHS
- IND
1 stop6h 10m
Southwest
Deal found 4/27![Southwest logo]()
$334
This United Airlines deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/147:05 am
IND
- HHH
1 stop5h 47m
United Airlines
Sat 9/193:00 pm
HHH
- IND
1 stop7h 07m
United Airlines
Deal found 4/28![United Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/171:41 pm
IND
- AGS
1 stop6h 08m
Delta
Sat 7/188:20 am
AGS
- IND
1 stop4h 16m
Delta
Deal found 4/27![Delta logo]()
$287
This Southwest deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1012:30 pm
IND
- SAV
2 stops8h 20m
Southwest
Fri 6/127:55 pm
SAV
- IND
1 stop4h 20m
Southwest
Deal found 4/29![Southwest logo]()
$334
This American Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/126:20 am
IND
- CAE
1 stop8h 19m
American Airlines
Sun 6/145:00 am
CAE
- IND
1 stop5h 38m
American Airlines
Deal found 4/26![American Airlines logo]()
$338
This Delta deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/47:59 pm
IND
- MYR
1 stop3h 59m
Delta
Mon 6/87:57 pm
MYR
- IND
1 stop4h 38m
Delta
Deal found 4/28![Delta logo]()
$289
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:10 am
IND
- CLT
2 stops10h 35m
Southwest
Wed 5/278:00 am
CLT
- IND
2 stops8h 35m
Southwest
Deal found 4/27![Southwest logo]()
$335
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/263:16 pm
IND
- GSP
1 stop6h 01m
United Airlines
Tue 6/22:16 pm
GSP
- IND
1 stop4h 45m
United Airlines
Deal found 4/27![United Airlines logo]()
$337
This Delta deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:40 am
IND
- CAE
1 stop6h 27m
Delta
Mon 5/257:17 pm
CAE
- IND
1 stop5h 16m
Delta
Deal found 4/27![Delta logo]()
$303
This Southwest deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:20 am
IND
- GSP
2 stops6h 55m
Southwest
Mon 6/221:55 pm
GSP
- IND
2 stops9h 10m
Southwest
Deal found 4/27![Southwest logo]()
$337
This United Airlines deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:30 am
IND
- SAV
2 stops7h 56m
United Airlines
Wed 5/208:01 am
SAV
- IND
1 stop5h 44m
United Airlines
Deal found 4/27![United Airlines logo]()
$356
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/125:55 pm
IND
- CAE
1 stop5h 19m
Delta
Mon 6/157:41 pm
CAE
- IND
1 stop4h 54m
Delta
Deal found 4/25![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/112:30 pm
IND
- CHS
2 stops8h 20m
Southwest
Wed 6/32:25 pm
CHS
- IND
2 stops6h 40m
Southwest
Deal found 4/25![Southwest logo]()
$342
This United Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/45:35 am
IND
- CHS
1 stop4h 41m
United Airlines
Tue 6/910:00 am
CHS
- IND
2 stops7h 44m
United Airlines
Deal found 4/26![United Airlines logo]()
$363
This American Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/31:58 pm
IND
- AGS
1 stop5h 52m
American Airlines
Sun 5/108:23 pm
AGS
- IND
1 stop3h 46m
American Airlines
Deal found 4/25![American Airlines logo]()
$441
Last-minute flights from Indianapolis to South CarolinaDiscover last-minute flight deals from Indianapolis to South Carolina. Data last updated April 30, 2026 and is based on user searches.
Discover last-minute flight deals from Indianapolis to South Carolina. Data last updated April 30, 2026 and is based on user searches.
This Cheapflightsfares deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Mon 5/118:30 am
SAV
- IND
Nonstop1h 51m
Allegiant Air
Deal found 4/28![Allegiant Air logo]()
$119
This Cheapflightsfares deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/411:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Fri 5/88:30 am
SAV
- IND
Nonstop1h 51m
Allegiant Air
Deal found 4/26![Allegiant Air logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/811:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Fri 5/158:30 am
SAV
- IND
Nonstop1h 51m
Allegiant Air
Deal found 4/27![Allegiant Air logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/811:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Mon 5/118:30 am
SAV
- IND
Nonstop1h 51m
Allegiant Air
Deal found 4/26![Allegiant Air logo]()
$100
This Cheapflightsfares deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1111:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Fri 5/158:30 am
SAV
- IND
Nonstop1h 51m
Allegiant Air
Deal found 4/26![Allegiant Air logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1111:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Mon 5/188:30 am
SAV
- IND
Nonstop1h 51m
Allegiant Air
Deal found 4/26![Allegiant Air logo]()
$127
This Cheapflightsfares deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1811:11 am
IND
- SAV
Nonstop1h 44m
Allegiant Air
Mon 5/258:46 pm
SAV
- IND
Nonstop1h 55m
Allegiant Air
Deal found 4/30![Allegiant Air logo]()
$108
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:40 pm
IND
- CLT
1 stop19h 31m
Multiple Airlines
Wed 5/207:58 pm
CLT
- IND
1 stop17h 03m
Multiple Airlines
Deal found 4/27![Multiple Airlines logo]()
$163
This Kiwi.com deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1812:26 pm
IND
- CLT
1 stop7h 36m
Multiple Airlines
Tue 5/195:35 pm
CLT
- IND
1 stop17h 46m
Multiple Airlines
Deal found 4/29![Multiple Airlines logo]()
$168
This Cheapflightsfares deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:59 pm
IND
- SAV
Nonstop1h 50m
Allegiant Air
Mon 5/258:46 pm
SAV
- IND
Nonstop1h 55m
Allegiant Air
Deal found 4/25![Allegiant Air logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2212:14 pm
IND
- CHS
2 stops31h 46m
Multiple Airlines
Fri 5/296:54 pm
CHS
- IND
Nonstop2h 00m
Multiple Airlines
Deal found 4/26![Multiple Airlines logo]()
$171
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/294:15 pm
IND
- CHS
Nonstop1h 49m
Allegiant Air
Fri 6/59:25 pm
CHS
- IND
Nonstop1h 56m
Allegiant Air
Deal found 4/28![Allegiant Air logo]()
$123
One-way flights from Indianapolis to South CarolinaSearch for one-way flight options from Indianapolis to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 30, 2026.
Search for one-way flight options from Indianapolis to South Carolina. Find affordable one-way fares based on user searches. Data last updated April 30, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:47 pm
IND
- CHS
Nonstop1h 48m
Allegiant Air
Deal found 4/28![Allegiant Air logo]()
$45
This Kiwi.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:51 pm
IND
- CHS
Nonstop1h 50m
Allegiant Air
Deal found 4/27![Allegiant Air logo]()
$58
This Cheapflightsfares deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2012:26 pm
IND
- CLT
1 stop11h 14m
Spirit Airlines
Deal found 4/29![Spirit Airlines logo]()
$74
This Booking.com deal was found by Cheapflights users on 4/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/312:26 pm
IND
- MYR
1 stop8h 10m
Spirit Airlines
Deal found 4/27![Spirit Airlines logo]()
$75
This Cheapflightsfares deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:15 am
IND
- MYR
Nonstop1h 46m
Allegiant Air
Deal found 4/28![Allegiant Air logo]()
$80
This Kiwi.com deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/2612:26 pm
IND
- CLT
1 stop11h 14m
Spirit Airlines
Deal found 4/26![Spirit Airlines logo]()
$80
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/910:07 pm
IND
- CLT
1 stop14h 05m
Frontier
Deal found 4/25![Frontier logo]()
$84
This Cheapflightsfares deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/3012:26 pm
IND
- CLT
1 stop11h 14m
Spirit Airlines
Deal found 4/29![Spirit Airlines logo]()
$89
This Trip.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:10 am
IND
- CLT
1 stop13h 03m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$94
This Cheapflightsfares deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/228:59 pm
IND
- SAV
Nonstop1h 50m
Allegiant Air
Deal found 4/26![Allegiant Air logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2712:26 pm
IND
- CLT
1 stop11h 14m
Spirit Airlines
Deal found 4/30![Spirit Airlines logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2912:14 pm
IND
- CLT
2 stops23h 20m
Multiple Airlines
Deal found 4/28![Multiple Airlines logo]()
$98
Find flight deals from Indianapolis to South Carolina
Keep the following information in mind while searching for Indianapolis to South Carolina flight deals. Data was last updated April 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $91 (Kiwi.com) |
One-way from | $45 (Cheapflightsfares) |
Popular in | March |
Cheapest in | August |
Average price | $390 |
Good round-trip deal | $104 or less |
Good one-way deal | $54 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Indianapolis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2026.
Use the filters below to find and compare flights from Indianapolis to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
IndianapolisCharleston
IND - CHS
INDCHS
Indianapolis
Fri 7/24
6:51 pm-8:41 pm
Nonstop1h 50m
Charleston
Mon 7/27
9:31 pm-11:25 pm
Nonstop1h 54m
$108
IndianapolisCharleston
IND - CHS
INDCHS
Indianapolis
Fri 6/5
6:47 pm-8:35 pm
Nonstop1h 48m
Charleston
Mon 6/8
9:28 pm-11:19 am
2 stops37h 51m
$258
IndianapolisColumbia
IND - CAE
INDCAE
Indianapolis
Wed 5/27
7:16 am-11:11 am
1 stop3h 55m
Columbia Metropolitan
Wed 6/3
5:40 am-10:14 am
1 stop4h 34m
$260
IndianapolisColumbia
IND - CAE
INDCAE
Indianapolis
Thu 6/18
8:05 am-1:02 pm
1 stop4h 57m
Columbia Metropolitan
Tue 6/30
7:01 am-2:06 pm
1 stop7h 05m
$270
IndianapolisAugusta
IND - AGS
INDAGS
Indianapolis
Fri 7/24
1:41 pm-7:49 pm
1 stop6h 08m
Augusta Bush Field
Wed 7/29
7:23 pm-12:41 am
1 stop5h 18m
$277
IndianapolisCharleston
IND - CHS
INDCHS
Indianapolis
Wed 5/27
6:00 am-12:10 pm
1 stop6h 10m
Charleston
Thu 5/28
6:03 pm-11:26 pm
1 stop5h 23m
$278
IndianapolisColumbia
IND - CAE
INDCAE
Indianapolis
Wed 5/27
7:05 am-2:16 pm
2 stops7h 11m
Columbia Metropolitan
Wed 6/3
2:29 pm-7:01 pm
1 stop4h 32m
$282
IndianapolisGreenville
IND - GSP
INDGSP
Indianapolis
Fri 7/10
7:00 am-2:25 pm
1 stop7h 25m
Greenville
Sun 7/12
3:51 pm-12:24 pm
1 stop20h 33m
$287
IndianapolisAugusta
IND - AGS
INDAGS
Indianapolis
Fri 7/17
1:41 pm-7:49 pm
1 stop6h 08m
Augusta Bush Field
Sat 7/18
8:20 am-12:36 pm
1 stop4h 16m
$287
IndianapolisMyrtle Beach
IND - MYR
INDMYR
Indianapolis
Thu 6/4
7:59 pm-11:58 pm
1 stop3h 59m
Myrtle Beach Intl
Mon 6/8
7:57 pm-12:35 am
1 stop4h 38m
$289
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Indianapolis to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indianapolis with our price prediction graph.
IND-SAV
IND-CHS
IND-CLT
IND-GSP
IND-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Indianapolis to South Carolina
IND-USSC
IND-SAV
IND-CHS
IND-CLT
IND-GSP
How far ahead should I book a flight from Indianapolis to South Carolina?
The price you pay for your flight from Indianapolis to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 45 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Indianapolis to South Carolina?
Currently, August is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $41). Flying from Indianapolis to South Carolina in January is currently the most expensive (average of $185). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from IND to SC?
Find hourly flight availability from Indianapolis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 30, 2026.
It’s optimal to fly from Indianapolis to South Carolina in the evening. By choosing this option you can save up to 71% on the cost of your flight, compared to a flight at noon.
How much does it cost to fly round-trip from Indianapolis to South Carolina?
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated April 30, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andAllegiant Air from Indianapolis to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Boarding
8.1
Crew
8.6
Entertainment
7.5
Overall
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Indianapolis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Indianapolis to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Indianapolis to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Indianapolis and South Carolina flights
Browse other Indianapolis and South Carolina flight options. Last updated on April 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Indianapolis to South Carolina flights
Consider these flights traveling from Indianapolis to South Carolina.
Top 6 airlines flying from Indianapolis to South Carolina
Discover the top 6 airlines that operate flights from Indianapolis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$61 | Average$127 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$95 | Average$190 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$158 | Average$353 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$196 | Average$419 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$208 | Average$346 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$247 | Average$408 | FlexibilityNo cancel fee | On-time63% |