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$45+ Cheap flights from Indianapolis (IND) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/1. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
Jul 18 — Jul 251
Sat 7/18
Sat 7/25
1 adult, Economy
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Cheap flight deals from Indianapolis to South Carolina

Cheapest flights from Indianapolis to South Carolina
Explore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 18, 2026.

This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/276:51 pm
IND
-
CHS
Nonstop1h 50m
Allegiant Air
Fri 7/319:37 pm
CHS
-
IND
Nonstop1h 54m
Allegiant Air
Deal found 6/13$77
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/276:51 pm
IND
-
CHS
Nonstop1h 50m
Allegiant Air
Mon 8/39:37 pm
CHS
-
IND
Nonstop1h 54m
Allegiant Air
Deal found 6/18$81
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:57 pm
IND
-
CHS
Nonstop1h 50m
Allegiant Air
Mon 8/39:37 pm
CHS
-
IND
Nonstop1h 54m
Allegiant Air
Deal found 6/14$95
This Kiwi.com deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:51 pm
IND
-
CHS
Nonstop1h 50m
Allegiant Air
Fri 7/319:37 pm
CHS
-
IND
Nonstop1h 54m
Allegiant Air
Deal found 6/18$97
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:51 pm
IND
-
CHS
Nonstop1h 50m
Allegiant Air
Mon 8/39:37 pm
CHS
-
IND
Nonstop1h 54m
Allegiant Air
Deal found 6/17$98
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:15 am
IND
-
MYR
Nonstop1h 46m
Allegiant Air
Sat 7/118:51 am
MYR
-
IND
Nonstop1h 46m
Allegiant Air
Deal found 6/13$105
This CheapOair deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:15 am
IND
-
MYR
Nonstop1h 46m
Allegiant Air
Sat 7/258:51 am
MYR
-
IND
Nonstop1h 46m
Allegiant Air
Deal found 6/18$111
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/116:15 am
IND
-
MYR
Nonstop1h 46m
Allegiant Air
Sat 7/188:51 am
MYR
-
IND
Nonstop1h 46m
Allegiant Air
Deal found 6/16$122
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:15 am
IND
-
MYR
Nonstop1h 46m
Allegiant Air
Sat 7/188:51 am
MYR
-
IND
Nonstop1h 46m
Allegiant Air
Deal found 6/17$126
This Mytrip deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/49:00 am
IND
-
SAV
Nonstop1h 46m
Allegiant Air
Sat 7/45:04 pm
SAV
-
IND
Nonstop1h 45m
Allegiant Air
Deal found 6/17$132
This Super.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/49:00 am
IND
-
SAV
Nonstop1h 46m
Allegiant Air
Sat 7/183:49 pm
SAV
-
IND
Nonstop1h 45m
Allegiant Air
Deal found 6/14$160
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/17:45 am
IND
-
SAV
Nonstop1h 46m
Multiple Airlines
Thu 8/610:05 am
SAV
-
IND
1 stop24h 07m
Multiple Airlines
Deal found 6/14$177

Find flight deals from Indianapolis to South Carolina

Keep the following information in mind while searching for Indianapolis to South Carolina flight deals. Data was last updated June 18, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$77
(Kiwi.com)

One-way from

$45
(Kiwi.com)

Popular in

March

Cheapest in

July

Average price

$277

Good round-trip deal

$86 or less
Provider with most accurate pricing for Indianapolis-Myrtle Beach Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Indianapolis-Myrtle Beach Intl flights.
Search Deals
From Indianapolis to South Carolina
Search Deals
One-way flight from Indianapolis to South Carolina
Search Deals
Highest demand for flights based on searches. 21% potential increase in price ($91 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
Search Deals
Price to beat on a round-trip flight from Indianapolis to South Carolina.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indianapolis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 18, 2026.
Use the filters below to find and compare flights from Indianapolis to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

Wed 7/29

4:10 pm-9:15 pm

1 stop5h 05m

Myrtle Beach Intl

Wed 8/5

7:50 am-12:20 pm

1 stop4h 30m

$271

IndianapolisGreenville

IND - GSP

INDGSP

Indianapolis

Wed 8/5

5:35 am-9:55 am

1 stop4h 20m

Greenville

Wed 8/5

5:43 pm-11:44 pm

1 stop6h 01m

$273

IndianapolisColumbia

IND - CAE

INDCAE

Indianapolis

Wed 7/15

6:00 am-10:09 am

1 stop4h 09m

Columbia Metropolitan

Sat 7/18

5:00 am-10:35 am

1 stop5h 35m

$275

IndianapolisGreenville

IND - GSP

INDGSP

Indianapolis

Tue 7/14

6:00 am-2:20 pm

2 stops8h 20m

Greenville

Tue 7/21

7:40 pm-11:59 pm

1 stop4h 19m

$278

IndianapolisGreenville

IND - GSP

INDGSP

Indianapolis

Wed 7/15

5:20 am-12:15 pm

2 stops6h 55m

Greenville

Tue 7/21

1:50 pm-7:15 pm

1 stop5h 25m

$278

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

Sat 8/22

6:35 am-12:45 pm

1 stop6h 10m

Myrtle Beach Intl

Wed 8/26

8:15 am-1:10 pm

1 stop4h 55m

$282

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

Tue 6/30

6:00 am-10:44 am

1 stop4h 44m

Myrtle Beach Intl

Fri 7/3

1:54 pm-7:44 pm

1 stop5h 50m

$285

IndianapolisAugusta

IND - AGS

INDAGS

Indianapolis

Tue 7/7

4:33 pm-9:30 pm

1 stop4h 57m

Augusta Bush Field

Mon 7/13

8:29 pm-12:41 am

1 stop4h 12m

$287

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

Wed 9/30

6:50 am-1:50 pm

2 stops7h 00m

Myrtle Beach Intl

Sat 10/3

8:20 am-12:25 pm

1 stop4h 05m

$287

IndianapolisColumbia

IND - CAE

INDCAE

Indianapolis

Fri 7/10

10:35 am-4:43 pm

1 stop6h 08m

Columbia Metropolitan

Sun 7/12

8:30 pm-12:09 am

1 stop3h 39m

$289

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/13

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Indianapolis to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indianapolis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indianapolis to South Carolina

What is the cheapest month to book a flight from Indianapolis to South Carolina?

Currently, August is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $41). Flying from Indianapolis to South Carolina in April is currently the most expensive (average of $270). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IND to SC?

Find hourly flight availability from Indianapolis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 18, 2026.

It’s optimal to fly from Indianapolis to South Carolina in the evening. By choosing this option you can save up to 70% on the cost of your flight, compared to a flight at noon.

How much does it cost to fly round-trip from Indianapolis to South Carolina?

How far ahead should I book a flight from Indianapolis to South Carolina?

The price you pay for your flight from Indianapolis to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 87 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated June 18, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Indianapolis to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
7.9
Good
4,236 reviews

Boarding

8.1

Comfort

8.0

Food

7.0

Overall

7.9

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

La Tracimeldamarcos,Jun 2026

LAX - SLC

The second flight was not as comfortable as the first as we had to change planes to what seemed to be a slightly older aircraft. The seats weren’t as comfortable as the other plane. But it wasn’t bad.
Southwest
7.9
Good
4,236 reviews
Southwest
7.9
Good
4,236 reviews

Boarding

8.1

Comfort

8.0

Food

7.0

Overall

7.9

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

La Tracimeldamarcos,Jun 2026

LAX - SLC

The second flight was not as comfortable as the first as we had to change planes to what seemed to be a slightly older aircraft. The seats weren’t as comfortable as the other plane. But it wasn’t bad.
Delta
7.8
Good
8,413 reviews
Southwest
7.9
Good
4,236 reviews

Boarding

8.1

Comfort

8.0

Food

7.0

Overall

7.9

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

La Tracimeldamarcos,Jun 2026

LAX - SLC

The second flight was not as comfortable as the first as we had to change planes to what seemed to be a slightly older aircraft. The seats weren’t as comfortable as the other plane. But it wasn’t bad.
United Airlines
7.4
Good
9,860 reviews
Southwest
7.9
Good
4,236 reviews

Boarding

8.1

Comfort

8.0

Food

7.0

Overall

7.9

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

La Tracimeldamarcos,Jun 2026

LAX - SLC

The second flight was not as comfortable as the first as we had to change planes to what seemed to be a slightly older aircraft. The seats weren’t as comfortable as the other plane. But it wasn’t bad.
Allegiant Air
7.3
Good
694 reviews
Southwest
7.9
Good
4,236 reviews

Boarding

8.1

Comfort

8.0

Food

7.0

Overall

7.9

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

La Tracimeldamarcos,Jun 2026

LAX - SLC

The second flight was not as comfortable as the first as we had to change planes to what seemed to be a slightly older aircraft. The seats weren’t as comfortable as the other plane. But it wasn’t bad.
American Airlines
7.1
Good
11,687 reviews
Southwest
7.9
Good
4,236 reviews

Boarding

8.1

Comfort

8.0

Food

7.0

Overall

7.9

Crew

8.6

Entertainment

7.5

Reviews

1 / 20
8.0
Excellent

La Tracimeldamarcos,Jun 2026

LAX - SLC

The second flight was not as comfortable as the first as we had to change planes to what seemed to be a slightly older aircraft. The seats weren’t as comfortable as the other plane. But it wasn’t bad.

Related info for your journey

Find useful and relevant information for your journey from Indianapolis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Indianapolis to South Carolina?

    Most people fly from Indianapolis (IND) if they book a flight from Indianapolis to South Carolina. Indianapolis is conveniently located just 8.3 mi from Indianapolis’s city center.

  • How popular is this Indianapolis to South Carolina flight route?

    The Indianapolis to South Carolina flight path was viewed by 3 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Indianapolis to South Carolina?

    For as low as $275, Southwest can have you in South Carolina from Indianapolis in 4h 09m. The distance between Indianapolis and South Carolina is about 490 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Indianapolis to South Carolina one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $45. However, be on the lookout for offers from American Airlines and Southwest, as they are both options that can get you from Indianapolis to South Carolina for a low price.

  • What are the most popular routes from Indianapolis to South Carolina?

    While some choose either Indianapolis - Charleston or Indianapolis - Myrtle Beach Intl, Indianapolis - Charlotte Douglas is the most popular route from Indianapolis to South Carolina.

  • What are the cheapest flights from Indianapolis to South Carolina?

    On average you can expect to pay $105 for a flight from Indianapolis to South Carolina. The cheapest flight overall is $74 while the most popular route, (Indianapolis - Charlotte Douglas) is currently priced at $256.

  • Can I find deals for flights from Indianapolis to South Carolina that include hotel bookings?

    Yes. In addition to deals on Indianapolis to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indianapolis to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indianapolis to South Carolina.

  • Can I find deals for business class flights from Indianapolis to South Carolina?

    Yes. Cheapflights offers flight deals from Indianapolis to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indianapolis to South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $41). Flying from Indianapolis to South Carolina in April is currently the most expensive (average of $270). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Indianapolis to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Indianapolis to South Carolina

Discover the top 5 airlines that operate flights from Indianapolis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 18, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$54Average$134FlexibilityNo cancel feeOn-time88%
DeltaCheapest$151Average$377FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$158Average$398FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$266Average$349FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$275Average$405FlexibilityNo cancel feeOn-time63%

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