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$61+ Cheap flights from Indianapolis (IND) to South Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Cheap flight deals from Indianapolis to South Carolina

Keep the following information in mind while searching for Indianapolis to South Carolina flight deals. Data was last updated November 6, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$176
(Kiwi.com)

One-way from

$61
(Frontier)

Popular in

December

Cheapest in

August

Average price

$346
Provider with most accurate pricing for Indianapolis-Myrtle Beach Intl flight deals.
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Provider most trusted by Cheapflights users for Indianapolis-Myrtle Beach Intl flights.
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From Indianapolis to South Carolina
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One-way flight from Indianapolis to South Carolina
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Highest demand for flights based on searches. 9% potential increase in price ($35 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
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Average for round-trip flights in November 2025
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Find flight deals from Indianapolis to South Carolina

Cheapest flights from Indianapolis to South Carolina
Explore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/1710:14 pmIND - CLT
1 stop15h 18mFrontier
Fri 11/2111:56 amCLT - IND
1 stop22h 23mFrontier
Deal found 11/5$177
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/159:36 pmIND - CLT
1 stop11h 26mFrontier
Mon 11/179:57 amCLT - IND
1 stop11h 22mFrontier
Deal found 11/5$181
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/58:48 amIND - SAV
1 stop27h 35mSpirit Airlines
Mon 12/81:18 pmSAV - IND
1 stop18h 25mSpirit Airlines
Deal found 11/6$183
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/58:48 amIND - CHS
1 stop26h 12mSpirit Airlines
Fri 12/129:49 pmCHS - IND
1 stop13h 09mSpirit Airlines
Deal found 11/5$185
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/155:24 pmIND - GSP
1 stop23h 24mAllegiant Air
Thu 12/183:25 pmGSP - IND
1 stop8h 07mAllegiant Air
Deal found 11/5$189
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:07 pmIND - SAV
1 stop14h 58mSpirit Airlines
Fri 12/51:18 pmSAV - IND
1 stop18h 25mSpirit Airlines
Deal found 11/6$190
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/912:03 pmIND - CHS
2 stops26h 26mMultiple Airlines
Sat 12/1311:55 amCHS - IND
1 stop19h 48mMultiple Airlines
Deal found 11/4$194
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/155:24 pmIND - GSP
1 stop23h 24mAllegiant Air
Fri 12/1910:04 pmGSP - IND
1 stop19h 24mAllegiant Air
Deal found 11/5$194
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/139:49 amIND - CLT
2 stops12h 19mMultiple Airlines
Fri 11/143:50 pmCLT - IND
1 stop28h 51mMultiple Airlines
Deal found 11/5$197
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/54:10 pmIND - CHS
2 stops18h 50mMultiple Airlines
Fri 12/129:49 pmCHS - IND
1 stop13h 09mMultiple Airlines
Deal found 11/5$199
This Kiwi.com deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1610:21 pmIND - CLT
1 stop10h 41mMultiple Airlines
Tue 11/185:40 pmCLT - IND
2 stops26h 24mMultiple Airlines
Deal found 11/6$199
This Kiwi.com deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/168:59 pmIND - CLT
1 stop12h 03mMultiple Airlines
Thu 11/203:51 pmCLT - IND
1 stop16h 56mMultiple Airlines
Deal found 11/4$200

Cheapflights Fare Finder

 
Customize your flight search to find flights from Indianapolis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Indianapolis to South Carolina that are best for you.

Fly from

Indianapolis

Fly to

South Carolina

Route

Depart

Return

Price

IndianapolisCharleston

IND - CHS

INDCHS

Indianapolis

Sun 2/22

5:15 am-5:30 pm

1 stop12h 15m

Charleston

Tue 2/24

5:18 pm-11:26 pm

1 stop6h 08m

$187

IndianapolisSavannah

IND - SAV

INDSAV

Indianapolis

Mon 12/1

6:07 pm-9:05 am

1 stop14h 58m

Savannah/Hilton Head

Fri 12/5

1:18 pm-7:43 am

1 stop18h 25m

$190

IndianapolisCharleston

IND - CHS

INDCHS

Indianapolis

Tue 12/9

12:03 pm-2:29 pm

2 stops26h 26m

Charleston

Sat 12/13

11:55 am-7:43 am

1 stop19h 48m

$194

IndianapolisGreenville

IND - GSP

INDGSP

Indianapolis

Mon 12/15

5:24 pm-4:48 pm

1 stop23h 24m

Greenville

Fri 12/19

10:04 pm-5:28 pm

1 stop19h 24m

$194

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Mon 12/8

11:19 am-9:50 am

1 stop22h 31m

Charlotte Douglas

Thu 12/11

3:07 pm-10:36 am

2 stops19h 29m

$201

IndianapolisMyrtle Beach

IND - MYR

INDMYR

Indianapolis

Thu 1/29

6:00 am-2:34 pm

1 stop8h 34m

Myrtle Beach Intl

Sun 2/1

9:53 am-12:18 am

1 stop14h 25m

$206

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Mon 11/24

9:03 am-5:13 pm

1 stop8h 10m

Charlotte Douglas

Thu 11/27

6:09 pm-8:08 am

1 stop13h 59m

$217

IndianapolisCharlotte

IND - CLT

INDCLT

Indianapolis

Mon 12/15

7:45 pm-12:04 pm

2 stops16h 19m

Charlotte Douglas

Sun 12/21

5:13 pm-9:27 am

1 stop16h 14m

$219

IndianapolisSavannah

IND - SAV

INDSAV

Indianapolis

Mon 12/1

6:07 pm-9:05 am

1 stop14h 58m

Savannah/Hilton Head

Fri 12/5

7:30 am-9:35 pm

2 stops14h 05m

$220

IndianapolisColumbia

IND - CAE

INDCAE

Indianapolis

Thu 11/20

11:34 am-4:54 pm

1 stop5h 20m

Columbia Metropolitan

Mon 11/24

5:00 pm-10:24 pm

1 stop5h 24m

$225

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/6

Showing 1-10 of 60 results
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Best time to book a flight from Indianapolis to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indianapolis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Indianapolis to South Carolina

What is the cheapest month to book a flight from Indianapolis to South Carolina?

Currently, October is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $41). Flying from Indianapolis to South Carolina in November is currently the most expensive (average of $86). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from IND to SC?

Find hourly flight availability from Indianapolis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

It’s optimal to fly from Indianapolis to South Carolina in the afternoon. By choosing this option you can save up to 32% on the cost of your flight, compared to a flight in the evening.

What is the cheapest day to fly from Indianapolis to South Carolina?

Use this chart to determine the cheapest time to fly round-trip from Indianapolis to South Carolina. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Indianapolis to South Carolina flight should consider departing on Wednesday mornings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South Carolina

Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 6, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and American Airlines from Indianapolis to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
8,001 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,040 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Allegiant Air
7.2
Good
697 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Spirit Airlines
6.3
Okay
8,122 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Indianapolis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Indianapolis to South Carolina?

    Most people fly from Indianapolis (IND) if they book a flight from Indianapolis to South Carolina. Indianapolis is conveniently located just 8.3 mi from Indianapolis’s city center.

  • How popular is this Indianapolis to South Carolina flight route?

    The Indianapolis to South Carolina flight path was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Indianapolis to South Carolina?

    For as low as $187, Spirit Airlines can have you in South Carolina from Indianapolis in 12h 15m. The distance between Indianapolis and South Carolina is about 585 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Indianapolis to South Carolina one-way?

    The cheapest airline one-way is Frontier, with whom users have recently found tickets for as low as $61. However, be on the lookout for offers from Spirit Airlines and Delta, as they are both options that can get you from Indianapolis to South Carolina for a low price.

  • What are the most popular routes from Indianapolis to South Carolina?

    While some choose either Indianapolis - Charleston or Indianapolis - Myrtle Beach Intl, Indianapolis - Charlotte Douglas is the most popular route from Indianapolis to South Carolina.

  • Can I find deals for flights from Indianapolis to South Carolina that include hotel bookings?

    Yes. In addition to deals on Indianapolis to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Indianapolis to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Indianapolis to South Carolina.

  • Can I find deals for business class flights from Indianapolis to South Carolina?

    Yes. Cheapflights offers flight deals from Indianapolis to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Indianapolis to South Carolina?

    Currently, October is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $41). Flying from Indianapolis to South Carolina in November is currently the most expensive (average of $86). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Indianapolis to South Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Indianapolis to South Carolina

Discover the top 6 airlines that operate flights from Indianapolis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$117FlexibilityNo cancel feeOn-time88%
Spirit AirlinesCheapest$128Average$209FlexibilityNo cancel feeOn-time65%
DeltaCheapest$196Average$362FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$209Average$374FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$228Average$371FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$247Average$401FlexibilityNo cancel feeOn-time63%

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