$45+ Cheap flights from Indianapolis (IND) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/13. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
Jul 15 — Jul 221
Round-trip
1 adult, Economy
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Find cheap flights from Indianapolis to South Carolina with Cheapflights
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Cheapest flights from Indianapolis to South CarolinaExplore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
Explore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 15, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/276:51 pm
IND
- CHS
Nonstop1h 50m
Allegiant Air
Fri 7/319:37 pm
CHS
- IND
Nonstop1h 54m
Allegiant Air
Deal found 6/13![Allegiant Air logo]()
$77
This Kissandfly.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kissandfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:57 pm
IND
- CHS
Nonstop1h 50m
Allegiant Air
Mon 8/39:37 pm
CHS
- IND
Nonstop1h 54m
Allegiant Air
Deal found 6/11![Allegiant Air logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:51 pm
IND
- CHS
Nonstop1h 50m
Allegiant Air
Fri 7/179:31 pm
CHS
- IND
Nonstop1h 54m
Allegiant Air
Deal found 6/12![Allegiant Air logo]()
$97
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/296:52 pm
IND
- CHS
Nonstop1h 48m
Allegiant Air
Fri 7/39:31 pm
CHS
- IND
Nonstop1h 54m
Allegiant Air
Deal found 6/12![Allegiant Air logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:51 pm
IND
- CHS
Nonstop1h 50m
Allegiant Air
Mon 7/209:31 pm
CHS
- IND
Nonstop1h 54m
Allegiant Air
Deal found 6/12![Allegiant Air logo]()
$102
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/266:52 pm
IND
- CHS
Nonstop1h 48m
Allegiant Air
Fri 7/39:31 pm
CHS
- IND
Nonstop1h 54m
Allegiant Air
Deal found 6/11![Allegiant Air logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:15 am
IND
- MYR
Nonstop1h 46m
Allegiant Air
Sat 7/118:51 am
MYR
- IND
Nonstop1h 46m
Allegiant Air
Deal found 6/13![Allegiant Air logo]()
$105
This CheapOair deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:15 am
IND
- MYR
Nonstop1h 46m
Allegiant Air
Sat 7/258:51 am
MYR
- IND
Nonstop1h 46m
Allegiant Air
Deal found 6/14![Allegiant Air logo]()
$135
This Cheapflightsfares deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/49:00 am
IND
- SAV
Nonstop1h 46m
Allegiant Air
Sat 7/45:04 pm
SAV
- IND
Nonstop1h 45m
Allegiant Air
Deal found 6/11![Allegiant Air logo]()
$139
This CheapOair deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/116:15 am
IND
- MYR
Nonstop1h 46m
Allegiant Air
Sat 7/188:51 am
MYR
- IND
Nonstop1h 46m
Allegiant Air
Deal found 6/13![Allegiant Air logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/206:15 am
IND
- MYR
Nonstop1h 45m
Allegiant Air
Sat 6/278:50 am
MYR
- IND
Nonstop1h 49m
Allegiant Air
Deal found 6/14![Allegiant Air logo]()
$143
This Super.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/49:00 am
IND
- SAV
Nonstop1h 46m
Allegiant Air
Sat 7/183:49 pm
SAV
- IND
Nonstop1h 45m
Allegiant Air
Deal found 6/14![Allegiant Air logo]()
$160
Best flights from Indianapolis to South CarolinaDiscover carefully curated flight deals from Indianapolis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
Discover carefully curated flight deals from Indianapolis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 15, 2026.
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:38 pm
IND
- CAE
1 stop5h 05m
Delta
Sat 7/255:55 pm
CAE
- IND
1 stop6h 25m
Delta
Deal found 6/13![Delta logo]()
$261
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/83:19 pm
IND
- CAE
1 stop5h 57m
United Airlines
Tue 7/147:45 pm
CAE
- IND
1 stop4h 14m
United Airlines
Deal found 6/12![United Airlines logo]()
$270
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:45 am
IND
- CLT
1 stop4h 25m
Southwest
Tue 9/81:30 pm
CLT
- IND
2 stops9h 15m
Southwest
Deal found 6/11![Southwest logo]()
$288
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/163:57 pm
IND
- GSP
1 stop22h 26m
Multiple Airlines
Fri 8/218:45 pm
GSP
- IND
1 stop22h 11m
Multiple Airlines
Deal found 6/15![Multiple Airlines logo]()
$296
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/262:52 pm
IND
- AGS
1 stop7h 25m
American Airlines
Sun 6/285:00 am
AGS
- IND
1 stop3h 57m
American Airlines
Deal found 6/10![American Airlines logo]()
$317
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:55 am
IND
- CAE
1 stop6h 04m
Delta
Mon 7/275:35 am
CAE
- IND
1 stop4h 58m
Delta
Deal found 6/13![Delta logo]()
$275
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:00 am
IND
- GSP
2 stops8h 20m
United Airlines
Tue 7/217:40 pm
GSP
- IND
1 stop4h 19m
United Airlines
Deal found 6/14![United Airlines logo]()
$278
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:25 am
IND
- MYR
1 stop4h 50m
Southwest
Mon 8/248:10 am
MYR
- IND
1 stop4h 00m
Southwest
Deal found 6/11![Southwest logo]()
$293
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:30 am
IND
- GSP
2 stops12h 09m
Multiple Airlines
Sun 8/98:37 am
GSP
- IND
1 stop25h 35m
Multiple Airlines
Deal found 6/10![Multiple Airlines logo]()
$303
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:55 am
IND
- AGS
1 stop3h 43m
Delta
Mon 7/137:23 pm
AGS
- IND
1 stop5h 18m
Delta
Deal found 6/12![Delta logo]()
$277
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/147:00 am
IND
- GSP
2 stops7h 20m
United Airlines
Tue 7/287:40 pm
GSP
- IND
1 stop4h 19m
United Airlines
Deal found 6/12![United Airlines logo]()
$278
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/412:20 pm
IND
- CAE
1 stop4h 23m
American Airlines
Sat 8/87:42 pm
CAE
- IND
1 stop3h 31m
American Airlines
Deal found 6/10![American Airlines logo]()
$321
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:20 am
IND
- CHS
2 stops7h 50m
Southwest
Wed 7/224:15 pm
CHS
- IND
1 stop7h 25m
Southwest
Deal found 6/11![Southwest logo]()
$306
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/19:21 am
IND
- GSP
1 stop4h 14m
United Airlines
Mon 10/126:20 am
GSP
- IND
1 stop6h 22m
United Airlines
Deal found 6/14![United Airlines logo]()
$293
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/69:10 am
IND
- GSP
1 stop6h 55m
Southwest
Sun 8/96:55 pm
GSP
- IND
1 stop4h 30m
Southwest
Deal found 6/10![Southwest logo]()
$310
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/249:40 am
IND
- AGS
1 stop4h 37m
American Airlines
Wed 7/295:00 am
AGS
- IND
1 stop3h 50m
American Airlines
Deal found 6/12![American Airlines logo]()
$371
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/912:15 pm
IND
- MYR
1 stop6h 55m
Southwest
Sat 9/1211:45 am
MYR
- IND
2 stops8h 25m
Southwest
Deal found 6/13![Southwest logo]()
$310
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:55 am
IND
- AGS
1 stop4h 12m
Delta
Wed 7/298:35 pm
AGS
- IND
1 stop4h 06m
Delta
Deal found 6/14![Delta logo]()
$343
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/243:15 pm
IND
- GSP
1 stop7h 50m
United Airlines
Wed 8/265:43 pm
GSP
- IND
1 stop5h 52m
United Airlines
Deal found 6/10![United Airlines logo]()
$320
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:33 am
IND
- HHH
1 stop7h 00m
American Airlines
Tue 7/2111:47 am
HHH
- IND
2 stops11h 19m
American Airlines
Deal found 6/14![American Airlines logo]()
$374
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:00 am
IND
- SAV
1 stop5h 40m
Southwest
Wed 7/151:25 pm
SAV
- IND
2 stops10h 05m
Southwest
Deal found 6/10![Southwest logo]()
$312
This Delta deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/165:55 am
IND
- CHS
1 stop4h 18m
Delta
Wed 7/225:10 am
CHS
- IND
1 stop3h 50m
Delta
Deal found 6/12![Delta logo]()
$345
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/205:45 am
IND
- MYR
1 stop3h 59m
United Airlines
Sun 8/2310:23 am
MYR
- IND
2 stops11h 37m
United Airlines
Deal found 6/11![United Airlines logo]()
$345
This Southwest deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:00 am
IND
- CLT
1 stop4h 05m
Southwest
Tue 10/207:20 am
CLT
- IND
2 stops6h 05m
Southwest
Deal found 6/12![Southwest logo]()
$314
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/12:35 pm
IND
- CHS
1 stop3h 33m
Delta
Sun 10/45:25 am
CHS
- IND
1 stop4h 11m
Delta
Deal found 6/10![Delta logo]()
$367
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:00 am
IND
- CHS
2 stops7h 35m
United Airlines
Sun 8/237:51 pm
CHS
- IND
1 stop4h 05m
United Airlines
Deal found 6/10![United Airlines logo]()
$347
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2211:00 am
IND
- CHS
2 stops8h 45m
Southwest
Sun 9/276:30 am
CHS
- IND
1 stop6h 25m
Southwest
Deal found 6/11![Southwest logo]()
$316
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1411:38 am
IND
- SAV
2 stops7h 57m
United Airlines
Tue 8/188:10 am
SAV
- IND
1 stop4h 37m
United Airlines
Deal found 6/12![United Airlines logo]()
$350
This Delta deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:46 pm
IND
- SAV
1 stop5h 34m
Delta
Thu 7/23:53 pm
SAV
- IND
1 stop3h 51m
Delta
Deal found 6/13![Delta logo]()
$387
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/47:40 am
IND
- CLT
2 stops11h 20m
Southwest
Tue 8/116:50 am
CLT
- IND
2 stops10h 05m
Southwest
Deal found 6/13![Southwest logo]()
$325
Last-minute flights from Indianapolis to South CarolinaDiscover last-minute flight deals from Indianapolis to South Carolina. Data last updated June 15, 2026 and is based on user searches.
Discover last-minute flight deals from Indianapolis to South Carolina. Data last updated June 15, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/206:15 am
IND
- MYR
Nonstop1h 45m
Allegiant Air
Sat 6/278:50 am
MYR
- IND
Nonstop1h 49m
Allegiant Air
Deal found 6/14![Allegiant Air logo]()
$143
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/266:52 pm
IND
- CHS
Nonstop1h 48m
Allegiant Air
Fri 7/39:31 pm
CHS
- IND
Nonstop1h 54m
Allegiant Air
Deal found 6/11![Allegiant Air logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/296:52 pm
IND
- CHS
Nonstop1h 48m
Allegiant Air
Fri 7/39:31 pm
CHS
- IND
Nonstop1h 54m
Allegiant Air
Deal found 6/12![Allegiant Air logo]()
$101
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:15 am
IND
- MYR
Nonstop1h 46m
Allegiant Air
Sat 7/118:51 am
MYR
- IND
Nonstop1h 46m
Allegiant Air
Deal found 6/13![Allegiant Air logo]()
$105
This Cheapflightsfares deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/49:00 am
IND
- SAV
Nonstop1h 46m
Allegiant Air
Sat 7/45:04 pm
SAV
- IND
Nonstop1h 45m
Allegiant Air
Deal found 6/11![Allegiant Air logo]()
$139
This Super.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/49:00 am
IND
- SAV
Nonstop1h 46m
Allegiant Air
Sat 7/183:49 pm
SAV
- IND
Nonstop1h 45m
Allegiant Air
Deal found 6/14![Allegiant Air logo]()
$160
This CheapOair deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/116:15 am
IND
- MYR
Nonstop1h 46m
Allegiant Air
Sat 7/188:51 am
MYR
- IND
Nonstop1h 46m
Allegiant Air
Deal found 6/13![Allegiant Air logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:51 pm
IND
- CHS
Nonstop1h 50m
Allegiant Air
Fri 7/179:31 pm
CHS
- IND
Nonstop1h 54m
Allegiant Air
Deal found 6/12![Allegiant Air logo]()
$97
This Kiwi.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:51 pm
IND
- CHS
Nonstop1h 50m
Allegiant Air
Mon 7/209:31 pm
CHS
- IND
Nonstop1h 54m
Allegiant Air
Deal found 6/12![Allegiant Air logo]()
$102
This CheapOair deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:15 am
IND
- MYR
Nonstop1h 46m
Allegiant Air
Sat 7/258:51 am
MYR
- IND
Nonstop1h 46m
Allegiant Air
Deal found 6/14![Allegiant Air logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/276:51 pm
IND
- CHS
Nonstop1h 50m
Allegiant Air
Fri 7/319:37 pm
CHS
- IND
Nonstop1h 54m
Allegiant Air
Deal found 6/13![Allegiant Air logo]()
$77
This Kissandfly.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kissandfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:57 pm
IND
- CHS
Nonstop1h 50m
Allegiant Air
Mon 8/39:37 pm
CHS
- IND
Nonstop1h 54m
Allegiant Air
Deal found 6/11![Allegiant Air logo]()
$95
One-way flights from Indianapolis to South CarolinaSearch for one-way flight options from Indianapolis to South Carolina. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
Search for one-way flight options from Indianapolis to South Carolina. Find affordable one-way fares based on user searches. Data last updated June 15, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/136:51 pm
IND
- CHS
Nonstop1h 50m
Allegiant Air
Deal found 6/11![Allegiant Air logo]()
$45
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:15 am
IND
- MYR
Nonstop1h 46m
Allegiant Air
Deal found 6/13![Allegiant Air logo]()
$45
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:15 am
IND
- MYR
Nonstop1h 46m
Allegiant Air
Deal found 6/13![Allegiant Air logo]()
$50
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/226:52 pm
IND
- CHS
Nonstop1h 48m
Allegiant Air
Deal found 6/13![Allegiant Air logo]()
$51
This Cheapflightsfares deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/266:52 pm
IND
- CHS
Nonstop1h 48m
Allegiant Air
Deal found 6/11![Allegiant Air logo]()
$58
This Kiwi.com deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/296:52 pm
IND
- CHS
Nonstop1h 48m
Allegiant Air
Deal found 6/15![Allegiant Air logo]()
$59
This Kiwi.com deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/116:15 am
IND
- MYR
Nonstop1h 46m
Allegiant Air
Deal found 6/13![Allegiant Air logo]()
$59
This Cheapflightsfares deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/196:52 pm
IND
- CHS
Nonstop1h 48m
Allegiant Air
Deal found 6/13![Allegiant Air logo]()
$68
This Frontier deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1210:53 am
IND
- CLT
1 stop6h 05m
Frontier
Deal found 6/13![Frontier logo]()
$105
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:50 am
IND
- CHS
1 stop6h 00m
Southwest
Deal found 6/11![Southwest logo]()
$108
This Expedia deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1611:09 am
IND
- CLT
1 stop25h 29m
Frontier
Deal found 6/12![Frontier logo]()
$111
This Trip.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/84:03 pm
IND
- GSP
1 stop15h 32m
Allegiant Air
Deal found 6/10![Allegiant Air logo]()
$113
Find flight deals from Indianapolis to South Carolina
Keep the following information in mind while searching for Indianapolis to South Carolina flight deals. Data was last updated June 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $77 (Kiwi.com) |
One-way from | $45 (Cheapflightsfares) |
Popular in | March |
Cheapest in | July |
Average price | $267 |
Good round-trip deal | $86 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Indianapolis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
Use the filters below to find and compare flights from Indianapolis to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
IndianapolisColumbia
IND - CAE
INDCAE
Indianapolis
Sat 7/18
6:38 pm-11:43 pm
1 stop5h 05m
Columbia Metropolitan
Sat 7/25
5:55 pm-12:20 am
1 stop6h 25m
$261
IndianapolisColumbia
IND - CAE
INDCAE
Indianapolis
Wed 7/8
3:19 pm-9:16 pm
1 stop5h 57m
Columbia Metropolitan
Tue 7/14
7:45 pm-11:59 pm
1 stop4h 14m
$270
IndianapolisColumbia
IND - CAE
INDCAE
Indianapolis
Tue 7/21
6:55 am-12:59 pm
1 stop6h 04m
Columbia Metropolitan
Mon 7/27
5:35 am-10:33 am
1 stop4h 58m
$275
IndianapolisAugusta
IND - AGS
INDAGS
Indianapolis
Tue 7/7
5:55 am-9:38 am
1 stop3h 43m
Augusta Bush Field
Mon 7/13
7:23 pm-12:41 am
1 stop5h 18m
$277
IndianapolisGreenville
IND - GSP
INDGSP
Indianapolis
Tue 7/14
6:00 am-2:20 pm
2 stops8h 20m
Greenville
Tue 7/21
7:40 pm-11:59 pm
1 stop4h 19m
$278
IndianapolisGreenville
IND - GSP
INDGSP
Indianapolis
Tue 7/14
7:00 am-2:20 pm
2 stops7h 20m
Greenville
Tue 7/28
7:40 pm-11:59 pm
1 stop4h 19m
$278
IndianapolisCharlotte
IND - CLT
INDCLT
Indianapolis
Thu 9/3
6:45 am-11:10 am
1 stop4h 25m
Charlotte Douglas
Tue 9/8
1:30 pm-10:45 pm
2 stops9h 15m
$288
IndianapolisMyrtle Beach
IND - MYR
INDMYR
Indianapolis
Mon 8/17
5:25 am-10:15 am
1 stop4h 50m
Myrtle Beach Intl
Mon 8/24
8:10 am-12:10 pm
1 stop4h 00m
$293
IndianapolisGreenville
IND - GSP
INDGSP
Indianapolis
Thu 10/1
9:21 am-1:35 pm
1 stop4h 14m
Greenville
Mon 10/12
6:20 am-12:42 pm
1 stop6h 22m
$293
IndianapolisGreenville
IND - GSP
INDGSP
Indianapolis
Sun 8/16
3:57 pm-2:23 pm
1 stop22h 26m
Greenville
Fri 8/21
8:45 pm-6:56 pm
1 stop22h 11m
$296
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Indianapolis to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indianapolis with our price prediction graph.
IND-CAE
IND-CLT
IND-GSP
IND-AGS
IND-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Indianapolis to South Carolina
IND-USSC
IND-CAE
IND-CLT
IND-GSP
IND-AGS
What is the cheapest month to book a flight from Indianapolis to South Carolina?
Currently, August is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $41). Flying from Indianapolis to South Carolina in April is currently the most expensive (average of $270). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from IND to SC?
Find hourly flight availability from Indianapolis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 15, 2026.
It’s optimal to fly from Indianapolis to South Carolina in the evening. By choosing this option you can save up to 70% on the cost of your flight, compared to a flight at noon.
How much does it cost to fly round-trip from Indianapolis to South Carolina?
How far ahead should I book a flight from Indianapolis to South Carolina?
The price you pay for your flight from Indianapolis to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 87 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated June 15, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Indianapolis to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
7.9
Entertainment
7.5
Comfort
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Overall
7.9
Entertainment
7.5
Comfort
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Overall
7.9
Entertainment
7.5
Comfort
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Overall
7.9
Entertainment
7.5
Comfort
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Overall
7.9
Entertainment
7.5
Comfort
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Overall
7.9
Entertainment
7.5
Comfort
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from Indianapolis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Indianapolis to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Indianapolis to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Indianapolis and South Carolina flights
Browse other Indianapolis and South Carolina flight options. Last updated on June 15, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Indianapolis to South Carolina flights
Consider these flights traveling from Indianapolis to South Carolina.
Top 5 airlines flying from Indianapolis to South Carolina
Discover the top 5 airlines that operate flights from Indianapolis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$54 | Average$134 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$151 | Average$377 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$158 | Average$398 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$266 | Average$349 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$275 | Average$405 | FlexibilityNo cancel fee | On-time63% |