$97+ Cheap flights from Indianapolis (IND) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/16. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
Nov 29 — Dec 61
Round-trip
1 adult, Economy
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Find cheap flights from Indianapolis to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Indianapolis to South Carolina
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Cheapest flights from Indianapolis to South CarolinaExplore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
Explore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1812:38 pm -
2 stops20h 54m
Mon 12/142:42 pm -
1 stop21h 43m
Deal found 10/26![Multiple Airlines logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/81:20 pm -
1 stop20h 08m
Mon 12/141:53 pm -
1 stop22h 32m
Deal found 10/26![Multiple Airlines logo]()
$181
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1812:38 pm -
1 stop6h 36m
Thu 11/1910:13 pm -
1 stop19h 07m
Deal found 10/29![Multiple Airlines logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/912:38 pm -
2 stops26h 51m
Fri 11/132:42 pm -
1 stop21h 11m
Deal found 10/25![Multiple Airlines logo]()
$207
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/511:04 am -
1 stop21h 34m
Wed 12/98:09 pm -
1 stop16h 16m
Deal found 10/27![Multiple Airlines logo]()
$213
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:52 pm -
2 stops15h 52m
Mon 12/71:53 pm -
1 stop22h 32m
Deal found 10/28![Multiple Airlines logo]()
$218
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/44:55 pm -
1 stop15h 43m
Mon 12/74:57 pm -
1 stop19h 28m
Deal found 10/28![Multiple Airlines logo]()
$227
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/157:19 pm -
2 stops40h 55m
Tue 1/128:17 pm -
1 stop23h 29m
Deal found 10/26![Multiple Airlines logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/912:38 pm -
1 stop21h 17m
Fri 11/136:12 pm -
2 stops17h 41m
Deal found 10/25![Multiple Airlines logo]()
$242
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:00 am -
1 stop3h 47m
Mon 11/237:19 pm -
1 stop3h 59m
Deal found 10/28![Delta logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/3010:56 am -
1 stop22h 59m
Sat 12/55:58 pm -
2 stops18h 27m
Deal found 10/27![Multiple Airlines logo]()
$248
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/195:35 pm -
2 stops15h 57m
Fri 1/83:30 pm -
1 stop20h 50m
Deal found 10/29![Multiple Airlines logo]()
$249
Best flights from Indianapolis to South CarolinaDiscover carefully curated flight deals from Indianapolis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
Discover carefully curated flight deals from Indianapolis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 30, 2026.
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/154:22 pm -
1 stop6h 00m
Fri 12/185:40 am -
1 stop3h 28m
Deal found 10/25![Delta logo]()
$295
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/257:40 pm -
1 stop3h 45m
Wed 12/27:05 am -
2 stops10h 25m
Deal found 10/28![Southwest logo]()
$308
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/184:24 pm -
1 stop6h 35m
Sat 11/218:28 pm -
1 stop4h 08m
Deal found 10/26![American Airlines logo]()
$319
This United Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/17:00 am -
1 stop6h 46m
Sat 2/612:36 pm -
1 stop5h 20m
Deal found 10/26![United Airlines logo]()
$325
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:30 am -
1 stop7h 38m
Thu 12/38:10 pm -
1 stop22h 39m
Deal found 10/30![Multiple Airlines logo]()
$374
This Southwest deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/42:10 pm -
1 stop5h 45m
Sun 12/68:15 am -
1 stop9h 45m
Deal found 10/25![Southwest logo]()
$316
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/176:00 am -
1 stop3h 40m
Wed 12/308:00 am -
1 stop3h 48m
Deal found 10/25![Delta logo]()
$317
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/219:05 am -
1 stop4h 41m
Mon 12/287:42 pm -
1 stop4h 17m
Deal found 10/29![United Airlines logo]()
$334
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/197:40 pm -
1 stop3h 25m
Fri 1/88:25 am -
1 stop4h 10m
Deal found 10/29![Southwest logo]()
$317
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:53 am -
1 stop4h 09m
Wed 11/187:12 pm -
1 stop4h 41m
Deal found 10/29![American Airlines logo]()
$349
This United Airlines deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/267:10 am -
2 stops7h 18m
Wed 12/210:23 am -
2 stops9h 11m
Deal found 10/25![United Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/197:40 pm -
1 stop3h 25m
Thu 1/71:05 pm -
1 stop3h 55m
Deal found 10/29![Southwest logo]()
$317
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/197:39 pm -
1 stop4h 20m
Sun 2/214:37 pm -
1 stop6h 17m
Deal found 10/30![American Airlines logo]()
$363
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/186:30 am -
1 stop4h 11m
Sat 12/267:03 pm -
1 stop5h 39m
Deal found 10/29![Delta logo]()
$366
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/39:40 am -
2 stops8h 45m
Tue 12/83:25 pm -
2 stops7h 25m
Deal found 10/28![Southwest logo]()
$317
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/195:45 am -
1 stop4h 21m
Sun 11/2210:23 am -
2 stops7h 29m
Deal found 10/29![United Airlines logo]()
$350
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/56:00 am -
1 stop3h 30m
Wed 11/117:00 am -
1 stop3h 43m
Deal found 10/27![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/266:00 am -
1 stop6h 00m
Tue 2/24:25 pm -
1 stop4h 53m
Deal found 10/29![American Airlines logo]()
$373
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1211:03 am -
2 stops8h 05m
Mon 11/165:37 pm -
1 stop4h 37m
Deal found 10/27![United Airlines logo]()
$354
This Southwest deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/197:40 pm -
1 stop3h 25m
Sat 1/94:30 pm -
2 stops6h 45m
Deal found 10/29![Southwest logo]()
$322
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/17:54 am -
1 stop6h 24m
Sun 12/65:54 pm -
1 stop6h 45m
Deal found 10/28![American Airlines logo]()
$373
This Delta deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:00 am -
1 stop4h 07m
Tue 12/16:00 am -
1 stop4h 38m
Deal found 10/25![Delta logo]()
$376
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:09 am -
2 stops11h 59m
Wed 11/187:54 pm -
1 stop4h 05m
Deal found 10/29![United Airlines logo]()
$354
This Southwest deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/97:25 am -
2 stops9h 20m
Tue 2/166:40 am -
1 stop5h 50m
Deal found 10/26![Southwest logo]()
$330
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/58:02 am -
1 stop6h 28m
Tue 1/124:25 pm -
1 stop4h 53m
Deal found 10/29![American Airlines logo]()
$373
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/256:00 am -
1 stop4h 01m
Fri 1/112:11 pm -
1 stop6h 28m
Deal found 10/26![Delta logo]()
$376
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/156:30 am -
2 stops12h 55m
Mon 1/186:30 am -
1 stop7h 05m
Deal found 10/27![Southwest logo]()
$333
This American Airlines deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/157:40 am -
1 stop4h 20m
Sun 1/174:25 pm -
1 stop4h 53m
Deal found 10/26![American Airlines logo]()
$375
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:00 am -
1 stop4h 13m
Tue 11/1711:19 am -
1 stop3h 57m
Deal found 10/26![Delta logo]()
$394
This Southwest deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/195:20 am -
1 stop4h 15m
Sat 1/96:35 pm -
1 stop4h 40m
Deal found 10/27![Southwest logo]()
$335
Last-minute flights from Indianapolis to South CarolinaDiscover last-minute flight deals from Indianapolis to South Carolina. Data last updated October 30, 2026 and is based on user searches.
Discover last-minute flight deals from Indianapolis to South Carolina. Data last updated October 30, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/212:38 pm -
2 stops23h 53m
Thu 11/510:13 pm -
1 stop13h 40m
Deal found 10/26![Multiple Airlines logo]()
$267
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/912:38 pm -
2 stops26h 51m
Fri 11/132:42 pm -
1 stop21h 11m
Deal found 10/25![Multiple Airlines logo]()
$207
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/912:38 pm -
1 stop21h 17m
Fri 11/136:12 pm -
2 stops17h 41m
Deal found 10/25![Multiple Airlines logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/1011:25 am -
1 stop21h 13m
Tue 11/173:00 pm -
1 stop19h 30m
Deal found 10/25![Multiple Airlines logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1112:38 pm -
1 stop26h 30m
Wed 11/182:42 pm -
1 stop23h 06m
Deal found 10/30![Multiple Airlines logo]()
$262
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1312:38 pm -
1 stop8h 23m
Sun 11/1510:13 pm -
1 stop13h 40m
Deal found 10/28![Multiple Airlines logo]()
$263
This Kiwi.com deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1812:38 pm -
2 stops20h 54m
Mon 12/142:42 pm -
1 stop21h 43m
Deal found 10/26![Multiple Airlines logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1812:38 pm -
1 stop6h 36m
Thu 11/1910:13 pm -
1 stop19h 07m
Deal found 10/29![Multiple Airlines logo]()
$184
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:00 am -
1 stop3h 47m
Mon 11/237:19 pm -
1 stop3h 59m
Deal found 10/28![Delta logo]()
$247
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1911:25 am -
1 stop8h 34m
Mon 11/232:33 pm -
2 stops28h 02m
Deal found 10/28![Multiple Airlines logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/252:23 pm -
1 stop18h 15m
Mon 11/304:57 pm -
1 stop19h 28m
Deal found 10/28![Multiple Airlines logo]()
$253
This Kiwi.com deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/3010:56 am -
1 stop22h 59m
Sat 12/55:58 pm -
2 stops18h 27m
Deal found 10/27![Multiple Airlines logo]()
$248
One-way flights from Indianapolis to South CarolinaSearch for one-way flight options from Indianapolis to South Carolina. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
Search for one-way flight options from Indianapolis to South Carolina. Find affordable one-way fares based on user searches. Data last updated October 30, 2026.
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/167:52 pm -
2 stops36h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Multiple Airlines logo]()
$97
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1112:38 pm -
1 stop6h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Multiple Airlines logo]()
$113
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/712:38 pm -
1 stop6h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Multiple Airlines logo]()
$122
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2512:44 pm -
2 stops19h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Multiple Airlines logo]()
$124
This Delta deal was found by Cheapflights users on 10/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/54:22 pm -
1 stop3h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/26![Delta logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/247:43 pm -
2 stops18h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Multiple Airlines logo]()
$130
This Southwest deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/165:35 am -
1 stop4h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Southwest logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 10/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2710:56 am -
1 stop20h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/25![Multiple Airlines logo]()
$140
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/195:35 pm -
2 stops38h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Multiple Airlines logo]()
$144
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/2512:44 pm -
2 stops19h 19m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/28![Multiple Airlines logo]()
$145
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/236:38 pm -
1 stop14h 00m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/29![Multiple Airlines logo]()
$149
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:10 am -
2 stops7h 18m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/27![United Airlines logo]()
$152
Find flight deals from Indianapolis to South Carolina
Keep the following information in mind while searching for Indianapolis to South Carolina flight deals. Data was last updated October 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $140 (Kiwi.com) |
One-way from | $97 (Kiwi.com) |
Popular in | November |
Cheapest in | July |
Average price | $352 |
Cheapflights Fare Finder
Customize your flight search to find flights from Indianapolis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
Use the filters below to find and compare flights from Indianapolis to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
IndianapolisCharleston
IND Indianapolis - CHS Charleston
INDCHS
Indianapolis
Wed 11/11
12:38 pm-7:14 pm
1 stop6h 36m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$113
IndianapolisGreenville
IND Indianapolis - GSP Greenville
INDGSP
Indianapolis
Sat 12/5
6:34 pm-11:01 pm
1 stop4h 27m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$124
IndianapolisGreenville
IND Indianapolis - GSP Greenville
INDGSP
Indianapolis
Sat 12/5
4:22 pm-7:57 pm
1 stop3h 35m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$124
IndianapolisCharleston
IND Indianapolis - CHS Charleston
INDCHS
Indianapolis
Thu 2/25
12:44 pm-7:58 am
2 stops19h 14m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$124
IndianapolisCharleston
IND Indianapolis - CHS Charleston
INDCHS
Indianapolis
Mon 11/16
5:35 am-10:20 am
1 stop4h 45m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$136
IndianapolisCharleston
IND Indianapolis - CHS Charleston
INDCHS
Indianapolis
Thu 11/19
6:00 am-12:52 pm
1 stop6h 52m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$136
IndianapolisGreenville
IND Indianapolis - GSP Greenville
INDGSP
Indianapolis
Fri 11/27
10:56 am-7:54 am
1 stop20h 58m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$140
IndianapolisMyrtle Beach
IND Indianapolis - MYR Myrtle Beach Intl
INDMYR
Indianapolis
Thu 2/25
12:44 pm-8:03 am
2 stops19h 19m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$145
IndianapolisCharleston
IND Indianapolis - CHS Charleston
INDCHS
Indianapolis
Thu 11/19
7:10 am-2:28 pm
2 stops7h 18m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$152
IndianapolisCharleston
IND Indianapolis - CHS Charleston
INDCHS
Indianapolis
Fri 2/12
6:30 am-12:00 pm
1 stop5h 30m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$155
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Indianapolis to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indianapolis with our price prediction graph.
IND-CHS
IND-GSP
IND-MYR
IND-HHH
IND-CAE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Indianapolis to South Carolina
IND-USSC
IND-CHS
IND-GSP
IND-MYR
IND-HHH
What is the cheapest month to book a flight from Indianapolis to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $184). Flying from Indianapolis to South Carolina in April is currently the most expensive (average of $445). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from IND to SC?
Find hourly flight availability from Indianapolis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2026.
It’s optimal to fly from Indianapolis to South Carolina in the evening. By choosing this option you can save up to 57% on the cost of your flight, compared to a flight in the morning.
How much does it cost to fly round-trip from Indianapolis to South Carolina?
Airfare is below average for this route at the moment.
Indianapolis to South Carolina flights typically cost between $352 and $756 in November.The cheapest round-trip price found within the last 5 days was $184 on Multiple Airlines (Nov 18-Nov 19).
How far ahead should I book a flight from Indianapolis to South Carolina?
The price you pay for your flight from Indianapolis to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 51 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated October 30, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Indianapolis to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.4
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Overall
7.9
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Entertainment
7.4
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Overall
7.9
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Entertainment
7.4
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Overall
7.9
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Entertainment
7.4
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Overall
7.9
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Entertainment
7.4
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Overall
7.9
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Entertainment
7.4
Boarding
8.1
Food
7.0
Comfort
8.0
Crew
8.6
Overall
7.9
Reviews
1 / 20
8.0
ExcellentPatricia,Oct 2026
DAL - TPA
Related info for your journey
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Complete your trip
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Indianapolis and South Carolina flights
Browse other Indianapolis and South Carolina flight options. Last updated on October 30, 2026.
Popular flight searches
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Indianapolis to South Carolina flights
Consider these flights traveling from Indianapolis to South Carolina.
Top 5 airlines flying from Indianapolis to South Carolina
Discover the top 5 airlines that operate flights from Indianapolis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$74 | Average$133 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$210 | Average$403 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$269 | Average$414 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$273 | Average$444 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$278 | Average$400 | FlexibilityNo cancel fee | On-time63% |