$103+ Cheap flights from Indianapolis (IND) to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/5. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
Oct 17 — Oct 241
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Indianapolis to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Indianapolis to South Carolina
Cheapest
Best
Last-minute
One-way
Cheapest flights from Indianapolis to South CarolinaExplore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
Explore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/611:21 am -
1 stop21h 17m
Tue 10/203:18 pm -
2 stops27h 46m
Deal found 9/14![Multiple Airlines logo]()
$218
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:00 am -
1 stop4h 10m
Wed 10/1411:15 am -
1 stop6h 32m
Deal found 9/16![Delta logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:06 pm -
1 stop11h 32m
Sat 10/317:10 pm -
2 stops48h 47m
Deal found 9/13![Multiple Airlines logo]()
$223
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/59:20 pm -
1 stop11h 18m
Wed 10/76:00 am -
2 stops12h 53m
Deal found 9/15![Multiple Airlines logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:52 pm -
2 stops36h 46m
Wed 12/28:09 pm -
1 stop22h 16m
Deal found 9/14![Multiple Airlines logo]()
$228
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:47 pm -
2 stops20h 04m
Tue 11/34:03 pm -
1 stop19h 50m
Deal found 9/15![Multiple Airlines logo]()
$228
This Frontier deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1410:22 pm -
1 stop12h 43m
Tue 10/2012:05 pm -
1 stop7h 55m
Deal found 9/13![Frontier logo]()
$230
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/27:33 am -
1 stop7h 17m
Sat 12/56:42 pm -
1 stop6h 04m
Deal found 9/15![American Airlines logo]()
$233
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/55:45 am -
1 stop4h 17m
Wed 10/76:50 pm -
1 stop4h 54m
Deal found 9/15![United Airlines logo]()
$235
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:59 pm -
2 stops36h 39m
Tue 10/203:18 pm -
1 stop19h 08m
Deal found 9/14![Multiple Airlines logo]()
$236
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/162:24 pm -
1 stop18h 14m
Wed 12/23:42 pm -
2 stops29h 03m
Deal found 9/15![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1311:25 am -
1 stop21h 12m
Mon 11/169:32 am -
1 stop24h 58m
Deal found 9/12![Frontier logo]()
$237
Best flights from Indianapolis to South CarolinaDiscover carefully curated flight deals from Indianapolis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
Discover carefully curated flight deals from Indianapolis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/173:03 pm -
1 stop6h 38m
Tue 10/206:00 am -
1 stop4h 10m
Deal found 9/15![United Airlines logo]()
$257
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/29:40 am -
2 stops8h 45m
Sat 12/510:35 am -
1 stop6h 10m
Deal found 9/14![Southwest logo]()
$264
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:00 am -
1 stop5h 38m
Fri 10/238:09 pm -
1 stop4h 16m
Deal found 9/15![Delta logo]()
$292
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/187:58 pm -
1 stop3h 49m
Fri 10/235:00 am -
1 stop5h 03m
Deal found 9/13![American Airlines logo]()
$383
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/910:33 am -
2 stops33h 11m
Tue 10/1310:44 am -
1 stop8h 59m
Deal found 9/16![Multiple Airlines logo]()
$442
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:35 am -
1 stop6h 40m
Thu 11/51:40 pm -
2 stops10h 40m
Deal found 9/13![Southwest logo]()
$281
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:04 am -
1 stop6h 17m
Tue 11/35:40 am -
1 stop5h 32m
Deal found 9/16![United Airlines logo]()
$303
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:30 am -
1 stop4h 15m
Thu 10/156:40 am -
1 stop5h 05m
Deal found 9/16![Southwest logo]()
$282
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1110:18 am -
1 stop5h 23m
Sun 12/131:59 pm -
1 stop5h 17m
Deal found 9/16![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/211:05 am -
1 stop5h 48m
Sat 12/56:00 am -
2 stops10h 26m
Deal found 9/15![United Airlines logo]()
$308
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/75:45 am -
1 stop4h 30m
Sat 11/74:00 pm -
1 stop4h 25m
Deal found 9/16![Southwest logo]()
$287
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/102:06 pm -
1 stop5h 01m
Sun 12/1311:53 am -
1 stop3h 24m
Deal found 9/15![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:10 am -
2 stops7h 18m
Wed 12/27:00 am -
2 stops11h 02m
Deal found 9/15![United Airlines logo]()
$311
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/172:52 pm -
1 stop5h 55m
Sun 11/228:59 am -
1 stop3h 44m
Deal found 9/12![American Airlines logo]()
$387
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/38:00 am -
1 stop4h 59m
Sun 12/66:19 am -
1 stop4h 19m
Deal found 9/16![Delta logo]()
$323
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/77:09 am -
2 stops7h 19m
Tue 11/107:00 am -
2 stops8h 00m
Deal found 9/15![United Airlines logo]()
$311
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:10 pm -
1 stop4h 55m
Wed 10/148:10 am -
1 stop6h 35m
Deal found 9/14![Southwest logo]()
$319
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/198:05 am -
1 stop4h 47m
Thu 12/38:00 am -
1 stop4h 59m
Deal found 9/15![Delta logo]()
$333
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:40 am -
1 stop4h 18m
Sun 10/116:20 am -
1 stop4h 36m
Deal found 9/15![United Airlines logo]()
$315
This American Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:57 pm -
1 stop4h 08m
Sun 10/46:00 am -
1 stop4h 26m
Deal found 9/12![American Airlines logo]()
$443
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:59 pm -
1 stop3h 58m
Sun 10/258:09 pm -
1 stop4h 16m
Deal found 9/15![Delta logo]()
$345
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:05 am -
2 stops8h 21m
Wed 10/215:38 pm -
1 stop6h 06m
Deal found 9/14![United Airlines logo]()
$318
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:05 am -
2 stops10h 20m
Sun 12/67:40 am -
1 stop4h 45m
Deal found 9/16![Southwest logo]()
$350
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:25 pm -
1 stop5h 26m
Fri 10/167:14 pm -
1 stop5h 11m
Deal found 9/15![Delta logo]()
$346
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:45 am -
1 stop4h 14m
Mon 11/25:37 pm -
1 stop4h 37m
Deal found 9/13![United Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/46:10 pm -
1 stop4h 55m
Tue 10/61:55 pm -
2 stops8h 05m
Deal found 9/15![Southwest logo]()
$364
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/309:31 am -
2 stops7h 10m
Wed 10/146:30 am -
1 stop3h 33m
Deal found 9/14![American Airlines logo]()
$492
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:41 am -
1 stop4h 01m
Thu 10/156:58 pm -
1 stop5h 27m
Deal found 9/16![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/156:00 am -
2 stops8h 10m
Sat 12/261:55 pm -
1 stop5h 30m
Deal found 9/16![Southwest logo]()
$367
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/36:50 am -
2 stops9h 55m
Sat 10/101:50 pm -
1 stop5h 38m
Deal found 9/13![American Airlines logo]()
$521
Last-minute flights from Indianapolis to South CarolinaDiscover last-minute flight deals from Indianapolis to South Carolina. Data last updated September 17, 2026 and is based on user searches.
Discover last-minute flight deals from Indianapolis to South Carolina. Data last updated September 17, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/59:20 pm -
1 stop11h 18m
Wed 10/76:00 am -
2 stops12h 53m
Deal found 9/15![Multiple Airlines logo]()
$226
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/55:45 am -
1 stop4h 17m
Wed 10/76:50 pm -
1 stop4h 54m
Deal found 9/15![United Airlines logo]()
$235
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/55:45 am -
1 stop4h 17m
Tue 10/63:00 pm -
2 stops7h 07m
Deal found 9/16![United Airlines logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/611:21 am -
1 stop21h 17m
Tue 10/203:18 pm -
2 stops27h 46m
Deal found 9/14![Multiple Airlines logo]()
$218
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:00 am -
1 stop4h 10m
Wed 10/1411:15 am -
1 stop6h 32m
Deal found 9/16![Delta logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:59 pm -
2 stops36h 39m
Tue 10/203:18 pm -
1 stop19h 08m
Deal found 9/14![Multiple Airlines logo]()
$236
This Frontier deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1410:22 pm -
1 stop12h 43m
Tue 10/2012:05 pm -
1 stop7h 55m
Deal found 9/13![Frontier logo]()
$230
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:59 pm -
1 stop4h 00m
Tue 10/204:20 pm -
1 stop4h 08m
Deal found 9/15![Delta logo]()
$249
This CheapOair deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2111:21 am -
1 stop25h 14m
Tue 10/279:32 am -
1 stop24h 58m
Deal found 9/13![Frontier logo]()
$240
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:06 pm -
1 stop11h 32m
Sat 10/317:10 pm -
2 stops48h 47m
Deal found 9/13![Multiple Airlines logo]()
$223
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:47 pm -
2 stops20h 04m
Tue 11/34:03 pm -
1 stop19h 50m
Deal found 9/15![Multiple Airlines logo]()
$228
This Expedia deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3112:38 pm -
1 stop6h 35m
Mon 11/26:05 am -
1 stop28h 25m
Deal found 9/14![Frontier logo]()
$245
One-way flights from Indianapolis to South CarolinaSearch for one-way flight options from Indianapolis to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
Search for one-way flight options from Indianapolis to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:48 pm -
2 stops36h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Multiple Airlines logo]()
$103
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:52 pm -
2 stops17h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![Frontier logo]()
$108
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/53:25 pm -
1 stop4h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Southwest logo]()
$111
This Super.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:06 pm -
1 stop11h 31m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Frontier logo]()
$114
This Frontier deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1412:38 pm -
1 stop6h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Frontier logo]()
$115
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/54:22 pm -
1 stop3h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Delta logo]()
$117
This Super.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1410:22 pm -
1 stop12h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![Frontier logo]()
$120
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:59 pm -
2 stops36h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Frontier logo]()
$123
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/237:59 pm -
2 stops23h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$124
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/51:49 pm -
1 stop7h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![United Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:52 pm -
2 stops23h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Multiple Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/159:40 pm -
2 stops24h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Frontier logo]()
$125
Find flight deals from Indianapolis to South Carolina
Keep the following information in mind while searching for Indianapolis to South Carolina flight deals. Data was last updated September 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $218 (Kiwi.com) |
One-way from | $103 (Kiwi.com) |
Popular in | March |
Cheapest in | July |
Average price | $386 |
Cheapflights Fare Finder
Customize your flight search to find flights from Indianapolis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
Use the filters below to find and compare flights from Indianapolis to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
IndianapolisCharleston
IND Indianapolis - CHS Charleston
INDCHS
Indianapolis
Sat 12/5
3:25 pm-8:05 pm
1 stop4h 40m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$111
IndianapolisGreenville
IND Indianapolis - GSP Greenville
INDGSP
Indianapolis
Sat 12/5
4:22 pm-7:57 pm
1 stop3h 35m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$117
IndianapolisCharleston
IND Indianapolis - CHS Charleston
INDCHS
Indianapolis
Mon 10/5
1:49 pm-9:33 pm
1 stop7h 44m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$125
IndianapolisGreenville
IND Indianapolis - GSP Greenville
INDGSP
Indianapolis
Fri 10/30
7:52 pm-10:32 am
2 stops38h 40m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$127
IndianapolisMyrtle Beach
IND Indianapolis - MYR Myrtle Beach Intl
INDMYR
Indianapolis
Sat 10/17
7:58 pm-11:47 pm
1 stop3h 49m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$129
IndianapolisGreenville
IND Indianapolis - GSP Greenville
INDGSP
Indianapolis
Fri 10/2
7:48 pm-9:32 am
3 stops37h 44m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$131
IndianapolisGreenville
IND Indianapolis - GSP Greenville
INDGSP
Indianapolis
Thu 10/29
3:10 pm-9:35 pm
1 stop6h 25m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$133
IndianapolisGreenville
IND Indianapolis - GSP Greenville
INDGSP
Indianapolis
Fri 10/23
7:59 pm-9:32 am
2 stops37h 33m
Greenville
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$133
IndianapolisCharleston
IND Indianapolis - CHS Charleston
INDCHS
Indianapolis
Mon 10/5
7:48 pm-8:38 am
2 stops36h 50m
Charleston
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$134
IndianapolisMyrtle Beach
IND Indianapolis - MYR Myrtle Beach Intl
INDMYR
Indianapolis
Fri 10/16
7:59 pm-8:47 am
2 stops36h 48m
Myrtle Beach Intl
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$135
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Indianapolis to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indianapolis with our price prediction graph.
IND-CHS
IND-GSP
IND-MYR
IND-SAV
IND-CLT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Indianapolis to South Carolina
IND-USSC
IND-CHS
IND-GSP
IND-MYR
IND-SAV
What is the cheapest month to book a flight from Indianapolis to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $184). Flying from Indianapolis to South Carolina in April is currently the most expensive (average of $445). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from IND to SC?
Find hourly flight availability from Indianapolis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2026.
It’s optimal to fly from Indianapolis to South Carolina in the evening. By choosing this option you can save up to 57% on the cost of your flight, compared to a flight in the morning.
How much does it cost to fly round-trip from Indianapolis to South Carolina?
Airfare is below average for this route at the moment.
Indianapolis to South Carolina flights typically cost between $320 and $486 in October.The cheapest round-trip price found within the last 5 days was $218 on Multiple Airlines (Oct 6-Oct 20).
How far ahead should I book a flight from Indianapolis to South Carolina?
The price you pay for your flight from Indianapolis to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 46 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 17, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Indianapolis to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Entertainment
7.5
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Crew
8.6
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Related info for your journey
Find useful and relevant information for your journey from Indianapolis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for Indianapolis to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Indianapolis to South Carolina by cabin class
Find flights from Indianapolis to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Indianapolis and South Carolina flights
Browse other Indianapolis and South Carolina flight options. Last updated on September 17, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Indianapolis to South Carolina flights
Consider these flights traveling from Indianapolis to South Carolina.
Top 5 airlines flying from Indianapolis to South Carolina
Discover the top 5 airlines that operate flights from Indianapolis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$74 | Average$133 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$183 | Average$395 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$230 | Average$419 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$266 | Average$444 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$278 | Average$402 | FlexibilityNo cancel fee | On-time63% |