$34+ Cheap flights from Indianapolis (IND) to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/8. Fares are subject to change and may not be available on all flights or dates of travel.
IND — CHS
Aug 29 — Sep 51
Round-trip
1 adult, Economy
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Find cheap flights from Indianapolis to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Indianapolis to South Carolina
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Cheapest flights from Indianapolis to South CarolinaExplore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2026.
Explore the most affordable flight options available from Indianapolis to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2026.
This CheapOair deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:10 am
IND
- MYR
Nonstop1h 46m
Allegiant Air
Sat 8/88:51 am
MYR
- IND
Nonstop1h 54m
Allegiant Air
Deal found 7/27![Allegiant Air logo]()
$124
This Frontier deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/269:59 pm
IND
- CLT
1 stop13h 00m
Frontier
Sat 8/298:56 am
CLT
- IND
1 stop9h 42m
Frontier
Deal found 7/28![Frontier logo]()
$200
This Frontier deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/209:59 pm
IND
- CLT
1 stop10h 02m
Frontier
Tue 8/258:56 am
CLT
- IND
1 stop9h 42m
Frontier
Deal found 7/30![Frontier logo]()
$208
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:00 am
IND
- CHS
1 stop25h 38m
Multiple Airlines
Sun 8/302:53 pm
CHS
- IND
2 stops26h 33m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$213
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:00 am
IND
- CHS
1 stop25h 38m
Multiple Airlines
Tue 9/13:13 pm
CHS
- IND
2 stops26h 13m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$214
This Super.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:33 pm
IND
- CLT
1 stop12h 28m
Frontier
Tue 8/258:56 am
CLT
- IND
1 stop9h 42m
Frontier
Deal found 7/27![Frontier logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/267:33 pm
IND
- CHS
1 stop13h 05m
Multiple Airlines
Sun 8/302:53 pm
CHS
- IND
2 stops26h 33m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$215
This Frontier deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:26 am
IND
- CLT
1 stop7h 55m
Frontier
Mon 9/149:32 am
CLT
- IND
1 stop10h 59m
Frontier
Deal found 7/30![Frontier logo]()
$216
This Trip.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:33 pm
IND
- CLT
1 stop12h 28m
Frontier
Wed 8/265:21 pm
CLT
- IND
1 stop26h 43m
Frontier
Deal found 7/27![Frontier logo]()
$221
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:33 pm
IND
- CHS
1 stop13h 05m
Multiple Airlines
Thu 8/274:51 pm
CHS
- IND
2 stops24h 35m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$222
This Frontier deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/209:59 pm
IND
- CLT
1 stop10h 02m
Frontier
Wed 8/268:56 am
CLT
- IND
1 stop9h 42m
Frontier
Deal found 7/26![Frontier logo]()
$223
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:11 pm
IND
- CHS
2 stops15h 26m
Multiple Airlines
Mon 8/312:16 pm
CHS
- IND
1 stop28h 22m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$229
Best flights from Indianapolis to South CarolinaDiscover carefully curated flight deals from Indianapolis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 30, 2026.
Discover carefully curated flight deals from Indianapolis to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 30, 2026.
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:35 am
IND
- MYR
1 stop6h 10m
Southwest
Mon 9/281:55 pm
MYR
- IND
2 stops8h 45m
Southwest
Deal found 7/27![Southwest logo]()
$276
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:00 am
IND
- GSP
1 stop4h 02m
American Airlines
Tue 8/256:34 pm
GSP
- IND
1 stop5h 24m
American Airlines
Deal found 7/29![American Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/207:02 am
IND
- GSP
1 stop3h 38m
Delta
Tue 8/256:55 am
GSP
- IND
1 stop3h 50m
Delta
Deal found 7/28![Delta logo]()
$279
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/67:00 am
IND
- GSP
2 stops7h 19m
United Airlines
Thu 9/1010:33 am
GSP
- IND
1 stop4h 44m
United Airlines
Deal found 7/26![United Airlines logo]()
$286
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/127:10 pm
IND
- CHS
1 stop13h 28m
Multiple Airlines
Mon 8/173:23 pm
CHS
- IND
2 stops50h 03m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$288
This Southwest deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:45 am
IND
- GSP
2 stops9h 20m
Southwest
Thu 9/34:40 pm
GSP
- IND
1 stop5h 45m
Southwest
Deal found 7/28![Southwest logo]()
$284
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/92:35 pm
IND
- CHS
1 stop5h 03m
Delta
Sat 9/127:00 am
CHS
- IND
1 stop3h 26m
Delta
Deal found 7/30![Delta logo]()
$285
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:00 am
IND
- CHS
1 stop4h 08m
Delta
Sat 9/266:26 pm
CHS
- IND
1 stop6h 06m
Delta
Deal found 7/26![Delta logo]()
$285
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/128:10 am
IND
- CHS
2 stops7h 45m
Southwest
Mon 9/146:30 pm
CHS
- IND
1 stop4h 10m
Southwest
Deal found 7/26![Southwest logo]()
$290
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/167:00 am
IND
- HHH
1 stop7h 03m
United Airlines
Wed 9/231:45 pm
HHH
- IND
1 stop8h 14m
United Airlines
Deal found 7/26![United Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1010:51 am
IND
- HHH
1 stop5h 54m
American Airlines
Mon 9/145:15 pm
HHH
- IND
1 stop3h 49m
American Airlines
Deal found 7/28![American Airlines logo]()
$333
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/67:50 am
IND
- GSP
2 stops5h 50m
Southwest
Thu 9/107:00 am
GSP
- IND
2 stops7h 50m
Southwest
Deal found 7/26![Southwest logo]()
$291
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/27:02 am
IND
- MYR
1 stop3h 45m
Delta
Tue 9/85:45 pm
MYR
- IND
1 stop6h 40m
Delta
Deal found 7/29![Delta logo]()
$295
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/217:24 am
IND
- HHH
1 stop4h 56m
American Airlines
Mon 1/253:29 pm
HHH
- IND
1 stop4h 04m
American Airlines
Deal found 7/28![American Airlines logo]()
$333
This United Airlines deal was found by Cheapflights users on 7/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/115:40 am
IND
- SAV
1 stop5h 20m
United Airlines
Thu 10/156:10 am
SAV
- IND
1 stop6h 32m
United Airlines
Deal found 7/25![United Airlines logo]()
$353
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:10 am
IND
- CHS
2 stops7h 30m
Southwest
Thu 8/201:15 pm
CHS
- IND
2 stops8h 10m
Southwest
Deal found 7/27![Southwest logo]()
$295
This Delta deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/24:43 pm
IND
- CAE
1 stop4h 28m
Delta
Sun 10/47:19 pm
CAE
- IND
1 stop4h 03m
Delta
Deal found 7/26![Delta logo]()
$299
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/115:40 am
IND
- CHS
1 stop4h 47m
United Airlines
Thu 10/156:00 am
CHS
- IND
2 stops6h 42m
United Airlines
Deal found 7/28![United Airlines logo]()
$356
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/1510:51 am
IND
- AGS
1 stop5h 50m
American Airlines
Tue 9/225:15 pm
AGS
- IND
1 stop3h 49m
American Airlines
Deal found 7/29![American Airlines logo]()
$357
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:45 am
IND
- MYR
2 stops7h 05m
Southwest
Sat 9/2611:45 am
MYR
- IND
2 stops8h 30m
Southwest
Deal found 7/29![Southwest logo]()
$297
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/217:02 am
IND
- GSP
1 stop5h 39m
Delta
Tue 8/255:20 pm
GSP
- IND
1 stop4h 03m
Delta
Deal found 7/28![Delta logo]()
$305
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:00 am
IND
- CAE
2 stops8h 21m
United Airlines
Sun 8/307:54 pm
CAE
- IND
1 stop4h 02m
United Airlines
Deal found 7/28![United Airlines logo]()
$361
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/218:05 am
IND
- GSP
1 stop5h 50m
Delta
Mon 8/242:51 pm
GSP
- IND
1 stop6h 32m
Delta
Deal found 7/27![Delta logo]()
$305
This Southwest deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/276:45 am
IND
- MYR
2 stops8h 00m
Southwest
Thu 9/36:40 am
MYR
- IND
2 stops8h 10m
Southwest
Deal found 7/29![Southwest logo]()
$305
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:00 am
IND
- AGS
1 stop3h 47m
American Airlines
Sun 9/208:15 pm
AGS
- IND
1 stop4h 05m
American Airlines
Deal found 7/29![American Airlines logo]()
$377
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:00 am
IND
- CAE
2 stops8h 21m
United Airlines
Wed 8/2610:22 am
CAE
- IND
2 stops9h 52m
United Airlines
Deal found 7/26![United Airlines logo]()
$366
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/217:00 am
IND
- SAV
1 stop6h 39m
Delta
Sat 10/245:05 pm
SAV
- IND
1 stop5h 24m
Delta
Deal found 7/27![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/215:20 pm
IND
- GSP
1 stop4h 15m
Southwest
Mon 8/247:00 am
GSP
- IND
2 stops7h 50m
Southwest
Deal found 7/27![Southwest logo]()
$310
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:00 am
IND
- HHH
1 stop4h 37m
American Airlines
Sun 9/206:29 pm
HHH
- IND
1 stop5h 51m
American Airlines
Deal found 7/27![American Airlines logo]()
$386
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/97:00 am
IND
- CHS
2 stops7h 50m
United Airlines
Sat 9/124:58 pm
CHS
- IND
1 stop5h 09m
United Airlines
Deal found 7/28![United Airlines logo]()
$370
Last-minute flights from Indianapolis to South CarolinaDiscover last-minute flight deals from Indianapolis to South Carolina. Data last updated July 30, 2026 and is based on user searches.
Discover last-minute flight deals from Indianapolis to South Carolina. Data last updated July 30, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:10 am
IND
- MYR
Nonstop1h 46m
Allegiant Air
Sat 8/88:51 am
MYR
- IND
Nonstop1h 54m
Allegiant Air
Deal found 7/27![Allegiant Air logo]()
$124
This Super.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:33 pm
IND
- CLT
1 stop12h 28m
Frontier
Tue 8/258:56 am
CLT
- IND
1 stop9h 42m
Frontier
Deal found 7/27![Frontier logo]()
$214
This Frontier deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/199:59 pm
IND
- CLT
1 stop13h 00m
Frontier
Sun 8/238:56 am
CLT
- IND
1 stop12h 18m
Frontier
Deal found 7/26![Frontier logo]()
$230
This Frontier deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/209:59 pm
IND
- CLT
1 stop10h 02m
Frontier
Tue 8/258:56 am
CLT
- IND
1 stop9h 42m
Frontier
Deal found 7/30![Frontier logo]()
$208
This Frontier deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/209:59 pm
IND
- CLT
1 stop10h 02m
Frontier
Wed 8/268:56 am
CLT
- IND
1 stop9h 42m
Frontier
Deal found 7/26![Frontier logo]()
$223
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:00 am
IND
- CHS
1 stop25h 38m
Multiple Airlines
Sun 8/302:53 pm
CHS
- IND
2 stops26h 33m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$213
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:00 am
IND
- CHS
1 stop25h 38m
Multiple Airlines
Tue 9/13:13 pm
CHS
- IND
2 stops26h 13m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$214
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:33 pm
IND
- CHS
1 stop13h 05m
Multiple Airlines
Thu 8/274:51 pm
CHS
- IND
2 stops24h 35m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$222
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:11 pm
IND
- CHS
2 stops15h 26m
Multiple Airlines
Mon 8/312:16 pm
CHS
- IND
1 stop28h 22m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$229
This Trip.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:33 pm
IND
- CLT
1 stop12h 28m
Frontier
Wed 8/265:21 pm
CLT
- IND
1 stop26h 43m
Frontier
Deal found 7/27![Frontier logo]()
$221
This Frontier deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/269:59 pm
IND
- CLT
1 stop13h 00m
Frontier
Sat 8/298:56 am
CLT
- IND
1 stop9h 42m
Frontier
Deal found 7/28![Frontier logo]()
$200
This Kiwi.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/267:33 pm
IND
- CHS
1 stop13h 05m
Multiple Airlines
Sun 8/302:53 pm
CHS
- IND
2 stops26h 33m
Multiple Airlines
Deal found 7/30![Multiple Airlines logo]()
$215
One-way flights from Indianapolis to South CarolinaSearch for one-way flight options from Indianapolis to South Carolina. Find affordable one-way fares based on user searches. Data last updated July 30, 2026.
Search for one-way flight options from Indianapolis to South Carolina. Find affordable one-way fares based on user searches. Data last updated July 30, 2026.
This CheapOair deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/86:15 am
IND
- MYR
Nonstop1h 46m
Allegiant Air
Deal found 7/29![Allegiant Air logo]()
$34
This Cheapflightsfares deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/36:57 pm
IND
- CHS
Nonstop1h 50m
Allegiant Air
Deal found 7/28![Allegiant Air logo]()
$68
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:33 pm
IND
- CHS
1 stop13h 05m
Multiple Airlines
Deal found 7/26![Multiple Airlines logo]()
$99
This Frontier deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2710:44 am
IND
- CLT
1 stop5h 54m
Frontier
Deal found 7/26![Frontier logo]()
$100
This Frontier deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/29:59 pm
IND
- CLT
1 stop13h 00m
Frontier
Deal found 7/26![Frontier logo]()
$105
This Frontier deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/269:59 pm
IND
- CLT
1 stop13h 00m
Frontier
Deal found 7/26![Frontier logo]()
$106
This Trip.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:33 pm
IND
- CLT
1 stop12h 28m
Frontier
Deal found 7/26![Frontier logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:48 pm
IND
- CLT
2 stops18h 20m
Frontier
Deal found 7/27![Frontier logo]()
$114
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2412:15 pm
IND
- CLT
1 stop19h 46m
Frontier
Deal found 7/26![Frontier logo]()
$115
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/216:11 pm
IND
- CHS
2 stops38h 27m
Multiple Airlines
Deal found 7/29![Multiple Airlines logo]()
$117
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/237:48 pm
IND
- GSP
2 stops26h 02m
Multiple Airlines
Deal found 7/27![Multiple Airlines logo]()
$118
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:27 pm
IND
- GSP
1 stop21h 17m
Allegiant Air
Deal found 7/27![Allegiant Air logo]()
$123
Find flight deals from Indianapolis to South Carolina
Keep the following information in mind while searching for Indianapolis to South Carolina flight deals. Data was last updated July 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $200 (Frontier) |
One-way from | $34 (CheapOair) |
Popular in | March |
Cheapest in | August |
Average price | $197 |
Good round-trip deal | $86 or less |
Good one-way deal | $59 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Indianapolis to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2026.
Use the filters below to find and compare flights from Indianapolis to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
IndianapolisMyrtle Beach
IND - MYR
INDMYR
Indianapolis
Sat 9/26
6:35 am-12:45 pm
1 stop6h 10m
Myrtle Beach Intl
Mon 9/28
1:55 pm-10:40 pm
2 stops8h 45m
$276
IndianapolisGreenville
IND - GSP
INDGSP
Indianapolis
Sat 8/22
6:00 am-10:02 am
1 stop4h 02m
Greenville
Tue 8/25
6:34 pm-11:58 pm
1 stop5h 24m
$279
Quickest round-trip
IndianapolisGreenville
IND - GSP
INDGSP
Indianapolis
Thu 8/20
7:02 am-10:40 am
1 stop3h 38m
Greenville
Tue 8/25
6:55 am-10:45 am
1 stop3h 50m
$279
IndianapolisGreenville
IND - GSP
INDGSP
Indianapolis
Thu 8/27
6:45 am-4:05 pm
2 stops9h 20m
Greenville
Thu 9/3
4:40 pm-10:25 pm
1 stop5h 45m
$284
IndianapolisCharleston
IND - CHS
INDCHS
Indianapolis
Wed 9/9
2:35 pm-7:38 pm
1 stop5h 03m
Charleston
Sat 9/12
7:00 am-10:26 am
1 stop3h 26m
$285
IndianapolisCharleston
IND - CHS
INDCHS
Indianapolis
Wed 9/23
6:00 am-10:08 am
1 stop4h 08m
Charleston
Sat 9/26
6:26 pm-12:32 am
1 stop6h 06m
$285
IndianapolisGreenville
IND - GSP
INDGSP
Indianapolis
Sun 9/6
7:00 am-2:19 pm
2 stops7h 19m
Greenville
Thu 9/10
10:33 am-3:17 pm
1 stop4h 44m
$286
IndianapolisCharleston
IND - CHS
INDCHS
Indianapolis
Wed 8/12
7:10 pm-8:38 am
1 stop13h 28m
Charleston
Mon 8/17
3:23 pm-5:26 pm
2 stops50h 03m
$288
IndianapolisCharleston
IND - CHS
INDCHS
Indianapolis
Sat 9/12
8:10 am-3:55 pm
2 stops7h 45m
Charleston
Mon 9/14
6:30 pm-10:40 pm
1 stop4h 10m
$290
IndianapolisGreenville
IND - GSP
INDGSP
Indianapolis
Sun 9/6
7:50 am-1:40 pm
2 stops5h 50m
Greenville
Thu 9/10
7:00 am-2:50 pm
2 stops7h 50m
$291
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Indianapolis to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Indianapolis with our price prediction graph.
IND-MYR
IND-CLT
IND-CHS
IND-GSP
IND-HHH
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Indianapolis to South Carolina
IND-USSC
IND-MYR
IND-CLT
IND-CHS
IND-GSP
What is the cheapest month to book a flight from Indianapolis to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Indianapolis to South Carolina (average of $197). Flying from Indianapolis to South Carolina in April is currently the most expensive (average of $446). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from IND to SC?
Find hourly flight availability from Indianapolis to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 30, 2026.
It’s optimal to fly from Indianapolis to South Carolina in the evening. By choosing this option you can save up to 55% on the cost of your flight, compared to a flight in the morning.
How much does it cost to fly round-trip from Indianapolis to South Carolina?
Airfare is below average for this route at the moment.
Indianapolis to South Carolina flights typically cost between $282 and $441 in August.The cheapest round-trip price found within the last 5 days was $213 on Multiple Airlines (Aug 24-Aug 30).
How far ahead should I book a flight from Indianapolis to South Carolina?
The price you pay for your flight from Indianapolis to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 45 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated July 30, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Indianapolis to South Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Overall
8.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Overall
8.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Overall
8.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Overall
8.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Overall
8.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Crew
8.6
Overall
8.0
Comfort
8.0
Boarding
8.1
Entertainment
7.5
Food
7.0
Reviews
1 / 20
8.0
ExcellentLibby,Jun 2026
TUS - LAS
Related info for your journey
Find useful and relevant information for your journey from Indianapolis to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Indianapolis to South Carolina
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Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Indianapolis to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Indianapolis and South Carolina flights
Browse other Indianapolis and South Carolina flight options. Last updated on July 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Indianapolis to South Carolina flights
Consider these flights traveling from Indianapolis to South Carolina.
Top 5 airlines flying from Indianapolis to South Carolina
Discover the top 5 airlines that operate flights from Indianapolis to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$74 | Average$134 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$158 | Average$387 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$211 | Average$405 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$250 | Average$399 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$279 | Average$402 | FlexibilityNo cancel fee | On-time63% |