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$65+ Cheap flights from Des Moines (DSM) to Indiana

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/3. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — IND
Jan 3 — Jan 101
Sat 1/3
Sat 1/10
1 adult, Economy
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Cheap flight deals from Des Moines to Indiana

Cheapest flights from Des Moines to Indiana
Explore the most affordable flight options available from Des Moines to Indiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.

This United Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:14 pmDSM - ORD
Nonstop1h 39mUnited Airlines
Thu 1/18:10 pmORD - DSM
Nonstop1h 30mUnited Airlines
Deal found 12/2$189
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:35 pmDSM - ORD
Nonstop1h 51mAmerican Airlines
Sat 1/109:40 amORD - DSM
Nonstop1h 32mAmerican Airlines
Deal found 12/2$204
This United Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/188:00 amDSM - ORD
Nonstop1h 38mUnited Airlines
Mon 12/228:10 pmORD - DSM
Nonstop1h 30mUnited Airlines
Deal found 12/2$219
This Delta deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:17 amDSM - MDW
1 stop6h 17mDelta
Sat 1/105:00 pmMDW - DSM
1 stop4h 24mDelta
Deal found 12/4$224
This Delta deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/194:59 pmDSM - ORD
1 stop4h 41mDelta
Sat 1/106:15 amORD - DSM
1 stop4h 04mDelta
Deal found 12/2$224
This Delta deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/216:59 amDSM - MDW
1 stop4h 07mDelta
Tue 1/279:50 amMDW - DSM
1 stop5h 51mDelta
Deal found 12/4$239
This Delta deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:50 amDSM - MDW
1 stop6h 20mDelta
Sat 1/311:48 amMDW - DSM
1 stop4h 53mDelta
Deal found 12/3$244
This Delta deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/194:59 pmDSM - ORD
1 stop4h 41mDelta
Sat 1/310:05 amORD - DSM
1 stop6h 36mDelta
Deal found 12/3$244
This United Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/318:00 amDSM - ORD
Nonstop1h 38mUnited Airlines
Fri 1/29:02 amORD - DSM
Nonstop1h 48mUnited Airlines
Deal found 12/3$249
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/313:26 pmDSM - DAY
1 stop5h 55mAmerican Airlines
Sun 1/47:30 pmDAY - DSM
1 stop6h 07mAmerican Airlines
Deal found 12/1$249
This United Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:46 pmDSM - ORD
Nonstop1h 39mUnited Airlines
Mon 12/298:10 pmORD - DSM
Nonstop1h 30mUnited Airlines
Deal found 12/2$250
This Delta deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/194:59 pmDSM - ORD
1 stop4h 41mDelta
Sat 1/176:15 amORD - DSM
1 stop4h 04mDelta
Deal found 12/3$254

Find flight deals from Des Moines to Indiana

Keep the following information in mind while searching for Des Moines to Indiana flight deals. Data was last updated December 4, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$148
(Kiwi.com)

One-way from

$65
(Southwest)

Popular in

June

Cheapest in

September

Average price

$310
Provider with most accurate pricing for Des Moines-Indianapolis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Indianapolis flights.
Search Deals
From Des Moines to Indiana
Search Deals
One-way flight from Des Moines to Indiana
Search Deals
Highest demand for flights based on searches. 5% potential increase in price ($20 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($6 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Indiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Des Moines to Indiana that are best for you.

Fly from

Des Moines

Fly to

Indiana

Route

Depart

Return

Price

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Tue 1/6

12:04 pm-5:26 pm

1 stop5h 22m

Chicago O'Hare Intl

Tue 1/13

6:15 am-10:19 am

1 stop4h 04m

$157

Des MoinesChicago

DSM - MDW

DSMMDW

Des Moines

Sat 1/10

10:59 am-4:16 pm

1 stop5h 17m

Chicago Midway

Wed 1/14

9:50 am-3:41 pm

1 stop5h 51m

$159

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Sat 1/10

6:24 am-1:08 pm

1 stop6h 44m

Chicago O'Hare Intl

Wed 1/14

1:55 pm-8:54 pm

1 stop6h 59m

$159

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Sat 2/14

6:19 am-1:22 pm

1 stop7h 03m

Chicago O'Hare Intl

Tue 2/17

8:52 am-3:40 pm

1 stop6h 48m

$159

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Wed 2/11

12:25 pm-4:57 pm

1 stop4h 32m

Chicago O'Hare Intl

Sat 2/14

6:15 am-10:17 am

1 stop4h 02m

$159

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Sat 1/17

6:24 am-1:08 pm

1 stop6h 44m

Chicago O'Hare Intl

Sat 1/24

6:15 am-10:19 am

1 stop4h 04m

$161

Des MoinesChicago

DSM - MDW

DSMMDW

Des Moines

Wed 2/11

3:20 pm-10:05 pm

2 stops6h 45m

Chicago Midway

Sat 2/14

12:50 pm-7:15 pm

2 stops6h 25m

$166

Des MoinesChicago

DSM - MDW

DSMMDW

Des Moines

Thu 1/29

3:20 pm-7:05 pm

1 stop3h 45m

Chicago Midway

Mon 2/2

2:10 pm-7:20 pm

1 stop5h 10m

$172

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Tue 1/6

3:35 pm-10:14 pm

1 stop5h 39m

Indianapolis

Thu 1/8

11:25 am-2:33 pm

1 stop4h 08m

$175

Des MoinesIndianapolis

DSM - IND

DSMIND

Des Moines

Sat 2/28

6:49 pm-11:44 pm

1 stop3h 55m

Indianapolis

Tue 3/3

6:00 am-10:53 am

1 stop5h 53m

$175

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/4

Showing 1-10 of 60 results
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Best time to book a flight from Des Moines to Indiana

Have a flexible travel schedule? Discover the best time to fly to Indiana from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Indiana

What is the cheapest month to book a flight from Des Moines to Indiana?

Currently, March is the cheapest month in which you can book a flight from Des Moines to Indiana (average of $179). Flying from Des Moines to Indiana in May is currently the most expensive (average of $303). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to IN?

Find hourly flight availability from Des Moines to Indiana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 4, 2025.

Unlike in the afternoon, when flights are generally more expensive, you can save up to 65% on flights from Des Moines to Indiana by exploring options for tickets in the evening.

Reviews of airlines servicing Indiana

Get insights into the airlines that provide service to Indiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indiana. Reviews last updated December 4, 2025.
Read through reviews of airlines operating flights from Des Moines to Indiana, such as Delta, United Airlines, and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,011 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,011 reviews
Delta
7.9
Good
8,011 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,066 reviews
Delta
7.9
Good
8,011 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,047 reviews
Delta
7.9
Good
8,011 reviews

Comfort

7.9

Overall

7.9

Boarding

8.1

Crew

8.5

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Indiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Indiana?

    Located just 3.6 mi from the city center, Des Moines (DSM) is the airport most travelers will use when flying to Indiana from Des Moines.

  • How long is the flight from Des Moines to Indiana?

    A quick flight from Des Moines to Indiana can take about 5h 22m. Delta provides one of the quickest options available for as low as $157. Airlines will cover a distance of 298 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Des Moines to Indiana?

    While some choose either Des Moines - Chicago Midway or Des Moines - Indianapolis, Des Moines - Chicago O'Hare Intl is the most popular route from Des Moines to Indiana.

  • Can I find deals for flights from Des Moines to Indiana that include hotel bookings?

    Yes. In addition to deals on Des Moines to Indiana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Indiana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Indiana.

  • Can I find deals for business class flights from Des Moines to Indiana?

    Yes. Cheapflights offers flight deals from Des Moines to Indiana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Indiana?

    Currently, March is the cheapest month in which you can book a flight from Des Moines to Indiana (average of $179). Flying from Des Moines to Indiana in May is currently the most expensive (average of $303). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Indiana

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Top 3 airlines flying from Des Moines to Indiana

Discover the top 3 airlines that operate flights from Des Moines to Indiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$196Average$308FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$196Average$323FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$210Average$386FlexibilityNo cancel feeOn-time69%

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