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$48+ Cheap flights from Des Moines (DSM) to Indiana

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/28. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — IND
Mar 26 — Apr 21
Thu 3/26
Thu 4/2
1 adult, Economy
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Cheap flight deals from Des Moines to Indiana

Cheapest flights from Des Moines to Indiana
Explore the most affordable flight options available from Des Moines to Indiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 24, 2026.

This United Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2811:26 am
DSM
-
ORD
Nonstop1h 36m
United Airlines
Mon 3/309:22 pm
ORD
-
DSM
Nonstop1h 37m
United Airlines
Deal found 2/21$126
This American Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/217:44 pm
DSM
-
ORD
Nonstop1h 33m
American Airlines
Sat 3/288:59 pm
ORD
-
DSM
Nonstop1h 35m
American Airlines
Deal found 2/22$131
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/17:44 pm
DSM
-
ORD
Nonstop1h 35m
American Airlines
Sat 4/411:40 am
ORD
-
DSM
Nonstop1h 25m
American Airlines
Deal found 2/23$144
This United Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/88:10 pm
DSM
-
ORD
Nonstop1h 36m
United Airlines
Sat 5/912:57 pm
ORD
-
DSM
Nonstop1h 27m
United Airlines
Deal found 2/23$155
This United Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:04 pm
DSM
-
ORD
Nonstop1h 34m
United Airlines
Sun 4/2612:59 pm
ORD
-
DSM
Nonstop1h 26m
United Airlines
Deal found 2/23$156
This Southwest deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:30 am
DSM
-
MDW
Nonstop1h 25m
Southwest
Wed 4/158:50 pm
MDW
-
DSM
Nonstop1h 20m
Southwest
Deal found 2/22$157
This United Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/178:04 am
DSM
-
ORD
Nonstop1h 32m
United Airlines
Mon 4/2010:52 am
ORD
-
DSM
Nonstop1h 37m
United Airlines
Deal found 2/22$157
This American Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:00 am
DSM
-
ORD
Nonstop1h 41m
American Airlines
Thu 4/166:53 am
ORD
-
DSM
Nonstop1h 33m
American Airlines
Deal found 2/23$158
This American Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/88:56 am
DSM
-
ORD
Nonstop1h 40m
American Airlines
Wed 4/159:00 am
ORD
-
DSM
Nonstop1h 26m
American Airlines
Deal found 2/22$159
This Southwest deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/14:20 pm
DSM
-
MDW
Nonstop1h 20m
Southwest
Sat 5/21:55 pm
MDW
-
DSM
1 stop7h 00m
Southwest
Deal found 2/21$160
This American Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/247:44 pm
DSM
-
ORD
Nonstop1h 35m
American Airlines
Tue 3/315:03 pm
ORD
-
DSM
Nonstop1h 25m
American Airlines
Deal found 2/22$161
This Southwest deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/25:35 am
DSM
-
MDW
Nonstop1h 20m
Southwest
Wed 4/86:30 am
MDW
-
DSM
1 stop7h 35m
Southwest
Deal found 2/20$167

Find flight deals from Des Moines to Indiana

Keep the following information in mind while searching for Des Moines to Indiana flight deals. Data was last updated February 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$126
(United Airlines)

One-way from

$48
(United Airlines)

Popular in

November

Cheapest in

September

Average price

$308
Provider with most accurate pricing for Des Moines-Indianapolis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Indianapolis flights.
Search Deals
From Des Moines to Indiana
Search Deals
One-way flight from Des Moines to Indiana
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($24 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Indiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 24, 2026.
Use the filters below to find and compare flights from Des Moines to Indiana that are best for you.

Fly from

Des Moines

Fly to

Indiana

Route

Depart

Return

Price

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Fri 4/3

6:20 am-7:56 am

Nonstop1h 36m

Chicago O'Hare Intl

Mon 4/6

7:55 pm-9:27 pm

Nonstop1h 32m

$157

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Fri 4/17

8:04 am-9:36 am

Nonstop1h 32m

Chicago O'Hare Intl

Mon 4/20

10:52 am-12:29 pm

Nonstop1h 37m

$157

Des MoinesChicago

DSM - MDW

DSMMDW

Des Moines

Fri 5/1

4:20 pm-5:40 pm

Nonstop1h 20m

Chicago Midway

Sat 5/2

10:05 am-11:30 am

Nonstop1h 25m

$169

Des MoinesChicago

DSM - MDW

DSMMDW

Des Moines

Fri 4/10

4:20 pm-5:40 pm

Nonstop1h 20m

Chicago Midway

Sun 4/12

10:00 am-11:25 am

Nonstop1h 25m

$169

Des MoinesChicago

DSM - MDW

DSMMDW

Des Moines

Thu 4/2

6:15 am-12:29 pm

1 stop6h 14m

Chicago Midway

Wed 4/8

9:30 am-3:42 pm

1 stop6h 12m

$177

Des MoinesChicago

DSM - MDW

DSMMDW

Des Moines

Tue 4/7

6:15 am-12:29 pm

1 stop6h 14m

Chicago Midway

Tue 4/14

9:29 am-3:41 pm

1 stop6h 12m

$177

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Wed 4/8

10:28 am-4:43 pm

1 stop6h 15m

Chicago O'Hare Intl

Wed 4/15

6:25 am-10:16 am

1 stop3h 51m

$177

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Tue 4/7

4:25 pm-7:49 pm

1 stop3h 24m

Chicago O'Hare Intl

Tue 4/14

6:25 am-10:16 am

1 stop3h 51m

$177

Des MoinesChicago

DSM - MDW

DSMMDW

Des Moines

Tue 4/7

5:30 am-6:55 am

Nonstop1h 25m

Chicago Midway

Tue 4/14

8:50 pm-10:10 pm

Nonstop1h 20m

$181

Des MoinesChicago

DSM - MDW

DSMMDW

Des Moines

Sat 4/25

5:35 am-6:55 am

Nonstop1h 20m

Chicago Midway

Sun 4/26

9:55 pm-11:20 pm

Nonstop1h 25m

$186

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/24

Showing 1-10 of 60 results
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Best time to book a flight from Des Moines to Indiana

Have a flexible travel schedule? Discover the best time to fly to Indiana from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Indiana

What is the cheapest month to book a flight from Des Moines to Indiana?

Currently, March is the cheapest month in which you can book a flight from Des Moines to Indiana (average of $179). Flying from Des Moines to Indiana in January is currently the most expensive (average of $304). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Indiana

Get insights into the airlines that provide service to Indiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indiana. Reviews last updated February 24, 2026.
Read through reviews of airlines operating flights from Des Moines to Indiana, such as Delta, United Airlines, and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,239 reviews

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Food

7.2

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,239 reviews
Delta
7.9
Good
8,239 reviews

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Food

7.2

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,344 reviews
Delta
7.9
Good
8,239 reviews

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Food

7.2

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,344 reviews
Delta
7.9
Good
8,239 reviews

Boarding

8.1

Comfort

7.9

Entertainment

7.8

Food

7.2

Crew

8.5

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Indiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Indiana?

    Located just 3.6 mi from the city center, Des Moines (DSM) is the airport most travelers will use when flying to Indiana from Des Moines.

  • How long is the flight from Des Moines to Indiana?

    A quick flight from Des Moines to Indiana can take about 1h 20m. United Airlines provides one of the quickest options available for as low as $169. Airlines will cover a distance of 305 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Des Moines to Indiana one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $98. Delta flights start at $123 while deals on United Airlines start at $125 one-way.

  • What are the most popular routes from Des Moines to Indiana?

    While some choose either Des Moines - Chicago Midway or Des Moines - Louisville Intl, Des Moines - Chicago O'Hare Intl is the most popular route from Des Moines to Indiana.

  • Can I find deals for flights from Des Moines to Indiana that include hotel bookings?

    Yes. In addition to deals on Des Moines to Indiana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Indiana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Indiana.

  • Can I find deals for business class flights from Des Moines to Indiana?

    Yes. Cheapflights offers flight deals from Des Moines to Indiana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Indiana?

    Currently, March is the cheapest month in which you can book a flight from Des Moines to Indiana (average of $179). Flying from Des Moines to Indiana in January is currently the most expensive (average of $304). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Indiana

See prices for flight routes from nearby airports that may be better suited for you.
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Cedar Rapids to Miami flights
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Cedar Rapids to LaGuardia flights

Top 3 airlines flying from Des Moines to Indiana

Discover the top 3 airlines that operate flights from Des Moines to Indiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$196Average$310FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$196Average$311FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$210Average$366FlexibilityNo cancel feeOn-time69%

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