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$71+ Cheap flights from Des Moines (DSM) to Indiana

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/7. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — IND
Feb 7 — Feb 141
Sat 2/7
Sat 2/14
1 adult, Economy
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Cheap flight deals from Des Moines to Indiana

Keep the following information in mind while searching for Des Moines to Indiana flight deals. Data was last updated January 8, 2026.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$141
(Southwest)

One-way from

$71
(Southwest)

Popular in

November

Cheapest in

September

Average price

$358
Provider with most accurate pricing for Des Moines-Indianapolis flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Indianapolis flights.
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From Des Moines to Indiana
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One-way flight from Des Moines to Indiana
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Highest demand for flights based on searches. 6% potential increase in price ($22 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Des Moines to Indiana

Cheapest flights from Des Moines to Indiana
Explore the most affordable flight options available from Des Moines to Indiana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 8, 2026.

This Southwest deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/175:30 amDSM - MDW
Nonstop1h 20mSouthwest
Tue 3/178:40 pmMDW - DSM
Nonstop1h 25mSouthwest
Deal found 1/8$141
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/187:44 pmDSM - ORD
Nonstop1h 35mAmerican Airlines
Wed 2/2511:40 amORD - DSM
Nonstop1h 25mAmerican Airlines
Deal found 1/6$141
This Southwest deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/315:30 amDSM - MDW
Nonstop1h 20mSouthwest
Tue 3/3110:15 amMDW - DSM
Nonstop1h 25mSouthwest
Deal found 1/6$142
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/115:01 pmDSM - ORD
Nonstop1h 47mAmerican Airlines
Mon 3/210:18 pmORD - DSM
Nonstop1h 22mAmerican Airlines
Deal found 1/6$157
This Delta deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:19 amDSM - MDW
1 stop6h 27mDelta
Wed 2/259:50 amMDW - DSM
1 stop5h 50mDelta
Deal found 1/7$161
This Delta deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:19 amDSM - ORD
1 stop7h 01mDelta
Wed 2/256:15 amORD - DSM
1 stop4h 02mDelta
Deal found 1/7$161
This Southwest deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/83:15 pmDSM - MDW
Nonstop1h 20mSouthwest
Sun 4/129:55 pmMDW - DSM
Nonstop1h 25mSouthwest
Deal found 1/7$165
This United Airlines deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/291:10 pmDSM - ORD
Nonstop1h 36mUnited Airlines
Tue 3/317:55 pmORD - DSM
Nonstop1h 32mUnited Airlines
Deal found 1/8$165
This Southwest deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/46:10 amDSM - MDW
1 stop3h 20mSouthwest
Wed 2/42:10 pmMDW - DSM
1 stop5h 10mSouthwest
Deal found 1/6$172
This Southwest deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/55:35 amDSM - MDW
Nonstop1h 20mSouthwest
Mon 3/910:45 amMDW - DSM
Nonstop1h 25mSouthwest
Deal found 1/8$173
This American Airlines deal was found by Cheapflights users on 1/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/511:42 amDSM - ORD
Nonstop1h 36mAmerican Airlines
Thu 2/1210:18 pmORD - DSM
Nonstop1h 22mAmerican Airlines
Deal found 1/8$173
This Southwest deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/23:20 pmDSM - MDW
1 stop3h 45mSouthwest
Wed 2/46:10 amMDW - DSM
1 stop5h 15mSouthwest
Deal found 1/6$177

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Indiana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
Use the filters below to find and compare flights from Des Moines to Indiana that are best for you.

Fly from

Des Moines

Fly to

Indiana

Route

Depart

Return

Price

Des MoinesChicago

DSM - MDW

DSMMDW

Des Moines

Tue 3/17

5:30 am-6:50 am

Nonstop1h 20m

Chicago Midway

Tue 3/17

8:40 pm-10:05 pm

Nonstop1h 25m

$141

Des MoinesChicago

DSM - MDW

DSMMDW

Des Moines

Tue 3/31

5:30 am-6:50 am

Nonstop1h 20m

Chicago Midway

Tue 3/31

10:15 am-11:40 am

Nonstop1h 25m

$142

Des MoinesChicago

DSM - MDW

DSMMDW

Des Moines

Tue 1/27

6:24 am-12:49 pm

1 stop6h 25m

Chicago Midway

Tue 2/3

9:53 am-3:41 pm

1 stop5h 48m

$161

Des MoinesChicago

DSM - MDW

DSMMDW

Des Moines

Wed 2/18

6:19 am-12:46 pm

1 stop6h 27m

Chicago Midway

Wed 2/25

9:50 am-3:40 pm

1 stop5h 50m

$161

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Tue 3/17

10:28 am-4:43 pm

1 stop6h 15m

Chicago O'Hare Intl

Wed 3/18

6:00 am-10:22 am

1 stop4h 22m

$161

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Tue 3/10

6:15 am-1:17 pm

1 stop7h 02m

Chicago O'Hare Intl

Tue 3/17

6:00 am-10:22 am

1 stop4h 22m

$161

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Wed 2/18

12:25 pm-4:41 pm

1 stop4h 16m

Chicago O'Hare Intl

Wed 2/25

8:50 am-3:40 pm

1 stop6h 50m

$161

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Tue 1/27

4:21 pm-9:43 pm

1 stop5h 22m

Chicago O'Hare Intl

Tue 2/3

6:15 am-10:51 am

1 stop4h 36m

$161

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Mon 3/16

6:49 pm-8:25 pm

Nonstop1h 36m

Chicago O'Hare Intl

Tue 3/17

12:55 pm-2:22 pm

Nonstop1h 27m

$165

Des MoinesChicago

DSM - ORD

DSMORD

Des Moines

Thu 2/12

8:00 am-9:36 am

Nonstop1h 36m

Chicago O'Hare Intl

Thu 2/19

1:00 pm-2:27 pm

Nonstop1h 27m

$173

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/8

Showing 1-10 of 60 results
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Best time to book a flight from Des Moines to Indiana

Have a flexible travel schedule? Discover the best time to fly to Indiana from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Indiana

What is the cheapest month to book a flight from Des Moines to Indiana?

Currently, March is the cheapest month in which you can book a flight from Des Moines to Indiana (average of $179). Flying from Des Moines to Indiana in January is currently the most expensive (average of $304). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Indiana

Get insights into the airlines that provide service to Indiana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Indiana. Reviews last updated January 8, 2026.
Read through reviews of airlines operating flights from Des Moines to Indiana, such as Delta, United Airlines, and American Airlines. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,025 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,025 reviews
Delta
7.9
Good
8,025 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,139 reviews
Delta
7.9
Good
8,025 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,094 reviews
Delta
7.9
Good
8,025 reviews

Entertainment

7.8

Food

7.2

Comfort

7.9

Crew

8.5

Overall

7.9

Boarding

8.1

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Indiana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Indiana?

    Located just 3.6 mi from the city center, Des Moines (DSM) is the airport most travelers will use when flying to Indiana from Des Moines.

  • How long is the flight from Des Moines to Indiana?

    A quick flight from Des Moines to Indiana can take about 1h 20m. Southwest provides one of the quickest options available for as low as $141. Airlines will cover a distance of 305 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Des Moines to Indiana?

    While some choose either Des Moines - Chicago Midway or Des Moines - Chicago Greater Rockford, Des Moines - Chicago O'Hare Intl is the most popular route from Des Moines to Indiana.

  • Can I find deals for flights from Des Moines to Indiana that include hotel bookings?

    Yes. In addition to deals on Des Moines to Indiana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Indiana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Indiana.

  • Can I find deals for business class flights from Des Moines to Indiana?

    Yes. Cheapflights offers flight deals from Des Moines to Indiana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Indiana?

    Currently, March is the cheapest month in which you can book a flight from Des Moines to Indiana (average of $179). Flying from Des Moines to Indiana in January is currently the most expensive (average of $304). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to Indiana

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Des Moines to Indiana

Discover the top 3 airlines that operate flights from Des Moines to Indiana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 8, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$196Average$308FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$196Average$319FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$210Average$365FlexibilityNo cancel feeOn-time69%

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