$548+ Cheap flights from Des Moines to Florence, SC (DSM - FLO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/30. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — FLO
Oct 22 — Oct 291
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to FlorenceExplore the most affordable flight options available from Des Moines to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
Explore the most affordable flight options available from Des Moines to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:08 am -
1 stop6h 01m
Wed 11/46:24 am -
1 stop4h 46m
Deal found 9/17![American Airlines logo]()
$548
Best flights from Des Moines to FlorenceDiscover carefully curated flight deals from Des Moines to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
Discover carefully curated flight deals from Des Moines to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:08 am -
1 stop6h 01m
Wed 11/46:24 am -
1 stop4h 46m
Deal found 9/17![American Airlines logo]()
$548
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/122:01 pm -
2 stops8h 56m
Mon 3/226:20 pm -
1 stop4h 59m
Deal found 9/17![American Airlines logo]()
$1,014
Last-minute flights from Des Moines to FlorenceDiscover last-minute flight deals from Des Moines to Florence. Data last updated September 22, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Florence. Data last updated September 22, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:08 am -
1 stop6h 01m
Wed 11/46:24 am -
1 stop4h 46m
Deal found 9/17![American Airlines logo]()
$548
Find flight deals from Des Moines to Florence
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $548 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
Use the filters below to find and compare flights from Des Moines to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesFlorence
DSM Des Moines - FLO Florence
DSMFLO
Des Moines
Fri 10/30
7:08 am-2:09 pm
1 stop6h 01m
Florence
Wed 11/4
6:24 am-10:10 am
1 stop4h 46m
$548
Des MoinesFlorence
DSM Des Moines - FLO Florence
DSMFLO
Des Moines
Fri 3/12
2:01 pm-11:57 pm
2 stops8h 56m
Florence
Mon 3/22
6:20 pm-10:19 pm
1 stop4h 59m
$1,014
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Des Moines-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Florence, South Carolina flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from Des Moines with our price prediction graph.
DSM-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
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