$116+ Cheap flights from Ohio to Des Moines (DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/17. Fares are subject to change and may not be available on all flights or dates of travel.
CLE — DSM
Oct 7 — Oct 141
Round-trip
1 adult, Economy
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Find cheap flights from Ohio to Des Moines with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Ohio to Des Moines
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Cheapest flights from Ohio to Des MoinesExplore the most affordable flight options available from Ohio to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
Explore the most affordable flight options available from Ohio to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 7, 2026.
This CheapOair deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:16 pm -
1 stop18h 28m
Mon 9/288:30 pm -
1 stop18h 41m
Deal found 9/5![Frontier logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:39 pm -
1 stop15h 56m
Mon 10/58:30 pm -
1 stop17h 58m
Deal found 9/2![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:39 pm -
1 stop15h 56m
Fri 10/98:25 pm -
1 stop26h 30m
Deal found 9/2![Multiple Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:08 am -
1 stop28h 36m
Fri 10/98:25 pm -
1 stop26h 30m
Deal found 9/2![Frontier logo]()
$282
This CheapOair deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/51:24 pm -
1 stop7h 09m
Mon 10/128:25 pm -
1 stop18h 20m
Deal found 9/7![Frontier logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/263:25 pm -
2 stops29h 32m
Mon 10/58:30 pm -
1 stop17h 58m
Deal found 9/2![Multiple Airlines logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:08 am -
1 stop28h 36m
Mon 10/58:30 pm -
1 stop17h 58m
Deal found 9/2![Frontier logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:57 pm -
1 stop12h 38m
Fri 10/28:30 pm -
1 stop17h 58m
Deal found 9/3![Multiple Airlines logo]()
$301
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:39 pm -
1 stop15h 56m
Thu 10/88:43 am -
1 stop28h 23m
Deal found 9/2![Multiple Airlines logo]()
$302
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:17 am -
1 stop4h 14m
Thu 10/86:00 am -
1 stop4h 55m
Deal found 9/2![United Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:35 pm -
1 stop23h 58m
Mon 10/58:30 pm -
1 stop17h 58m
Deal found 9/3![Frontier logo]()
$307
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:00 am -
1 stop4h 42m
Sat 10/174:01 pm -
1 stop6h 50m
Deal found 9/3![Delta logo]()
$309
Best flights from Ohio to Des MoinesDiscover carefully curated flight deals from Ohio to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
Discover carefully curated flight deals from Ohio to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 7, 2026.
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/206:50 pm -
1 stop4h 10m
Thu 10/224:30 pm -
1 stop4h 40m
Deal found 9/2![Southwest logo]()
$309
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:00 am -
1 stop5h 42m
Wed 10/145:50 pm -
1 stop3h 45m
Deal found 9/2![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:02 am -
2 stops7h 32m
Thu 10/86:55 pm -
1 stop3h 59m
Deal found 9/2![United Airlines logo]()
$314
This Priceline deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/181:24 pm -
1 stop7h 09m
Sun 9/2011:29 am -
1 stop8h 10m
Deal found 9/3![Frontier logo]()
$315
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/27:21 pm -
1 stop5h 43m
Thu 10/82:26 pm -
1 stop5h 00m
Deal found 9/2![American Airlines logo]()
$319
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/512:59 pm -
1 stop20h 22m
Sun 11/812:25 pm -
1 stop23h 45m
Deal found 9/2![Multiple Airlines logo]()
$343
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/11:40 pm -
2 stops10h 30m
Sat 10/31:20 pm -
2 stops7h 20m
Deal found 9/2![Southwest logo]()
$319
This American Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/257:24 pm -
1 stop5h 40m
Mon 9/285:57 pm -
1 stop4h 55m
Deal found 9/2![American Airlines logo]()
$322
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:00 am -
1 stop4h 32m
Fri 10/308:00 am -
1 stop3h 56m
Deal found 9/3![United Airlines logo]()
$322
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/148:35 am -
1 stop3h 55m
Thu 10/157:10 pm -
2 stops13h 45m
Deal found 9/2![Southwest logo]()
$320
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:00 am -
1 stop4h 31m
Sun 10/258:00 am -
1 stop4h 10m
Deal found 9/3![United Airlines logo]()
$348
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:39 pm -
1 stop4h 47m
Sat 10/36:00 am -
2 stops8h 38m
Deal found 9/2![Delta logo]()
$383
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:30 pm -
1 stop6h 44m
Wed 11/41:58 pm -
1 stop6h 55m
Deal found 9/3![American Airlines logo]()
$353
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:30 pm -
1 stop3h 30m
Fri 10/305:10 am -
2 stops8h 45m
Deal found 9/3![Southwest logo]()
$327
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/249:42 pm -
1 stop25h 26m
Wed 9/302:42 pm -
2 stops27h 13m
Deal found 9/2![Multiple Airlines logo]()
$419
This Delta deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/174:42 pm -
1 stop5h 31m
Wed 11/1811:00 am -
1 stop3h 49m
Deal found 9/4![Delta logo]()
$383
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:06 pm -
1 stop4h 17m
Sun 10/46:55 pm -
1 stop4h 04m
Deal found 9/2![United Airlines logo]()
$366
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:25 pm -
1 stop5h 35m
Thu 9/245:40 am -
2 stops10h 05m
Deal found 9/2![Southwest logo]()
$343
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/196:40 am -
1 stop6h 11m
Sun 12/206:42 pm -
1 stop4h 51m
Deal found 9/3![Delta logo]()
$400
This United Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/27:17 am -
1 stop4h 14m
Sat 10/36:00 am -
1 stop4h 55m
Deal found 9/6![United Airlines logo]()
$372
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/173:45 pm -
2 stops7h 15m
Wed 11/186:00 am -
2 stops10h 25m
Deal found 9/4![Southwest logo]()
$357
This United Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:30 am -
1 stop6h 01m
Fri 10/91:24 pm -
1 stop4h 42m
Deal found 9/4![United Airlines logo]()
$377
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/248:40 am -
Nonstop2h 06m
Sun 11/296:10 am -
Nonstop1h 53m
Deal found 9/3![Delta logo]()
$419
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:55 am -
1 stop8h 25m
Tue 10/203:00 pm -
1 stop4h 10m
Deal found 9/2![Southwest logo]()
$363
This American Airlines deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:46 am -
1 stop7h 22m
Mon 11/27:23 am -
1 stop15h 30m
Deal found 9/4![American Airlines logo]()
$490
This Delta deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/78:45 am -
Nonstop1h 57m
Tue 11/106:10 am -
Nonstop1h 53m
Deal found 9/6![Delta logo]()
$419
This United Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/207:00 am -
1 stop4h 31m
Wed 10/2111:27 am -
1 stop4h 38m
Deal found 9/3![United Airlines logo]()
$384
This Southwest deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/711:40 am -
2 stops11h 20m
Wed 10/145:35 am -
2 stops6h 10m
Deal found 9/6![Southwest logo]()
$365
This Delta deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:45 am -
Nonstop1h 57m
Sun 11/110:22 am -
Nonstop1h 45m
Deal found 9/2![Delta logo]()
$419
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/102:11 pm -
1 stop4h 46m
Fri 9/115:45 am -
1 stop7h 59m
Deal found 9/2![United Airlines logo]()
$386
Last-minute flights from Ohio to Des MoinesDiscover last-minute flight deals from Ohio to Des Moines. Data last updated September 7, 2026 and is based on user searches.
Discover last-minute flight deals from Ohio to Des Moines. Data last updated September 7, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:16 pm -
1 stop18h 28m
Mon 9/288:30 pm -
1 stop18h 41m
Deal found 9/5![Frontier logo]()
$225
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/263:25 pm -
2 stops29h 32m
Mon 10/58:30 pm -
1 stop17h 58m
Deal found 9/2![Multiple Airlines logo]()
$295
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:08 am -
1 stop28h 36m
Fri 10/98:25 pm -
1 stop26h 30m
Deal found 9/2![Frontier logo]()
$282
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:08 am -
1 stop28h 36m
Mon 10/58:30 pm -
1 stop17h 58m
Deal found 9/2![Frontier logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:39 pm -
1 stop15h 56m
Mon 10/58:30 pm -
1 stop17h 58m
Deal found 9/2![Multiple Airlines logo]()
$270
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:39 pm -
1 stop15h 56m
Fri 10/98:25 pm -
1 stop26h 30m
Deal found 9/2![Multiple Airlines logo]()
$281
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:57 pm -
1 stop12h 38m
Fri 10/28:30 pm -
1 stop17h 58m
Deal found 9/3![Multiple Airlines logo]()
$301
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:39 pm -
1 stop15h 56m
Thu 10/88:43 am -
1 stop28h 23m
Deal found 9/2![Multiple Airlines logo]()
$302
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:35 pm -
1 stop23h 58m
Mon 10/58:30 pm -
1 stop17h 58m
Deal found 9/3![Frontier logo]()
$307
This CheapOair deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/51:24 pm -
1 stop7h 09m
Mon 10/128:25 pm -
1 stop18h 20m
Deal found 9/7![Frontier logo]()
$289
This United Airlines deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:17 am -
1 stop4h 14m
Thu 10/86:00 am -
1 stop4h 55m
Deal found 9/2![United Airlines logo]()
$304
This Delta deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:00 am -
1 stop4h 42m
Sat 10/174:01 pm -
1 stop6h 50m
Deal found 9/3![Delta logo]()
$309
One-way flights from Ohio to Des MoinesSearch for one-way flight options from Ohio to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 7, 2026.
Search for one-way flight options from Ohio to Des Moines. Find affordable one-way fares based on user searches. Data last updated September 7, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/173:46 pm -
2 stops23h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$116
This Trip.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:39 pm -
1 stop15h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Multiple Airlines logo]()
$120
This Kiwi.com deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/710:14 am -
1 stop13h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Multiple Airlines logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/29:10 pm -
1 stop20h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Multiple Airlines logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:23 pm -
1 stop25h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Multiple Airlines logo]()
$130
This Frontier deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:50 am -
1 stop12h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Frontier logo]()
$135
This Frontier deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/67:50 am -
1 stop12h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Frontier logo]()
$136
This CheapOair deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/127:08 am -
1 stop13h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/2![Frontier logo]()
$138
This Trip.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/18:35 pm -
1 stop23h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Frontier logo]()
$139
This Kiwi.com deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/34:23 pm -
1 stop29h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Multiple Airlines logo]()
$140
This CheapOair deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/48:35 pm -
1 stop23h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/5![Frontier logo]()
$141
This Priceline deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/211:24 pm -
1 stop7h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/6![Frontier logo]()
$160
Find flight deals from Ohio to Des Moines
Keep the following information in mind while searching for Ohio to Des Moines flight deals. Data was last updated September 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $225 (CheapOair) |
One-way from | $116 (Kiwi.com) |
Popular in | June |
Cheapest in | November |
Average price | $628 |
Cheapflights Fare Finder
Customize your flight search to find flights from Ohio to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 7, 2026.
Use the filters below to find and compare flights from Ohio to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
DetroitDes Moines
DTW Detroit Metropolitan Wayne County - DSM Des Moines
DTWDSM
Detroit Metropolitan Wayne County
Thu 10/1
5:39 pm-8:35 am
1 stop15h 56m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$120
ClevelandDes Moines
CLE Cleveland Hopkins Intl - DSM Des Moines
CLEDSM
Cleveland Hopkins Intl
Mon 9/21
1:24 pm-7:33 pm
1 stop7h 09m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$160
ClevelandDes Moines
CLE Cleveland Hopkins Intl - DSM Des Moines
CLEDSM
Cleveland Hopkins Intl
Thu 10/8
7:29 pm-7:30 pm
1 stop25h 01m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$161
DetroitDes Moines
DTW Detroit Metropolitan Wayne County - DSM Des Moines
DTWDSM
Detroit Metropolitan Wayne County
Sun 9/20
8:35 pm-7:33 pm
1 stop23h 58m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$171
ColumbusDes Moines
CMH Columbus - DSM Des Moines
CMHDSM
Columbus
Wed 11/25
5:46 am-9:00 am
1 stop4h 14m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$174
ClevelandDes Moines
CLE Cleveland Hopkins Intl - DSM Des Moines
CLEDSM
Cleveland Hopkins Intl
Sat 10/17
9:10 am-12:00 pm
1 stop3h 50m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$182
DetroitDes Moines
DTW Detroit Metropolitan Wayne County - DSM Des Moines
DTWDSM
Detroit Metropolitan Wayne County
Mon 10/12
5:25 am-11:10 am
2 stops6h 45m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$187
DetroitDes Moines
DTW Detroit Metropolitan Wayne County - DSM Des Moines
DTWDSM
Detroit Metropolitan Wayne County
Thu 12/3
5:30 am-11:25 am
2 stops6h 55m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$187
PittsburghDes Moines
PIT Pittsburgh - DSM Des Moines
PITDSM
Pittsburgh
Tue 10/27
5:59 pm-9:43 pm
1 stop4h 44m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$189
PittsburghDes Moines
PIT Pittsburgh - DSM Des Moines
PITDSM
Pittsburgh
Thu 10/1
8:47 pm-12:04 am
1 stop4h 17m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$189
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Ohio to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Ohio with our price prediction graph.
DTW-DSM
CLE-DSM
CMH-DSM
PIT-DSM
DAY-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Ohio to Des Moines
USOH-DSM
DTW-DSM
CLE-DSM
CMH-DSM
PIT-DSM
What is the cheapest month to book a flight from Ohio to Des Moines?
Currently, October is the cheapest month in which you can book a flight from Ohio to Des Moines (average of $337). Flying from Ohio to Des Moines in January is currently the most expensive (average of $577). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Ohio to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
Ames
Johnston
Boone
Norwalk
West Des Moines
Ankeny
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Alternative routes for Ohio to Des Moines
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Complete your trip
Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 7, 2026.
Search flights from Ohio to Des Moines by cabin class
Find flights from Ohio to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Ohio and Des Moines flights
Browse other Ohio and Des Moines flight options. Last updated on September 7, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Ohio to Des Moines flights
Consider these flights traveling from Ohio to Des Moines.
Top 4 airlines flying from Ohio to Des Moines
Discover the top 4 airlines that operate flights from Ohio to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$203 | Average$391 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$248 | Average$427 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$269 | Average$419 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$302 | Average$411 | FlexibilityNo cancel fee | On-time63% |