$120+ Cheap flights from Ohio to Des Moines (DSM)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/16. Fares are subject to change and may not be available on all flights or dates of travel.
CLE — DSM
Nov 24 — Dec 11
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Ohio to Des MoinesExplore the most affordable flight options available from Ohio to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
Explore the most affordable flight options available from Ohio to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 25, 2026.
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:56 pm -
1 stop4h 59m
Wed 11/118:00 am -
1 stop4h 10m
Deal found 10/20![United Airlines logo]()
$239
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/198:05 pm -
1 stop3h 55m
Tue 1/56:00 am -
2 stops10h 25m
Deal found 10/23![Southwest logo]()
$244
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:59 pm -
1 stop4h 27m
Tue 11/179:25 am -
1 stop5h 53m
Deal found 10/20![American Airlines logo]()
$249
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:10 am -
1 stop9h 05m
Sun 11/225:25 am -
1 stop3h 35m
Deal found 10/20![Southwest logo]()
$264
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:10 pm -
1 stop3h 55m
Thu 11/265:10 am -
2 stops6h 35m
Deal found 10/21![Southwest logo]()
$265
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/225:21 am -
1 stop4h 45m
Tue 12/295:30 am -
1 stop6h 49m
Deal found 10/23![American Airlines logo]()
$269
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/113:10 pm -
2 stops8h 55m
Sat 12/1212:45 pm -
2 stops8h 05m
Deal found 10/20![Southwest logo]()
$274
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/196:30 am -
1 stop6h 26m
Sun 12/206:15 am -
1 stop3h 58m
Deal found 10/22![Delta logo]()
$287
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:00 am -
1 stop5h 44m
Wed 11/256:52 pm -
1 stop4h 38m
Deal found 10/20![Delta logo]()
$291
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/169:00 am -
1 stop6h 14m
Sat 12/268:00 am -
1 stop4h 16m
Deal found 10/22![United Airlines logo]()
$311
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:42 pm -
1 stop4h 17m
Fri 11/276:45 pm -
1 stop4h 14m
Deal found 10/21![United Airlines logo]()
$315
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:00 am -
1 stop4h 49m
Sun 12/611:35 am -
1 stop5h 05m
Deal found 10/21![Delta logo]()
$324
Best flights from Ohio to Des MoinesDiscover carefully curated flight deals from Ohio to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
Discover carefully curated flight deals from Ohio to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 25, 2026.
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/295:54 pm -
1 stop3h 51m
Mon 1/45:15 pm -
1 stop5h 55m
Deal found 10/20![Delta logo]()
$239
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:55 pm -
1 stop4h 10m
Tue 11/245:10 am -
1 stop3h 35m
Deal found 10/20![Southwest logo]()
$249
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:42 pm -
1 stop4h 17m
Fri 11/276:45 pm -
1 stop4h 14m
Deal found 10/21![United Airlines logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/512:59 pm -
1 stop20h 22m
Mon 11/98:30 pm -
2 stops37h 49m
Deal found 10/21![Multiple Airlines logo]()
$331
This American Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/79:40 am -
2 stops10h 13m
Wed 11/111:58 pm -
1 stop6h 27m
Deal found 10/23![American Airlines logo]()
$450
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/184:17 pm -
1 stop3h 58m
Wed 11/256:52 pm -
1 stop4h 38m
Deal found 10/21![Delta logo]()
$239
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:10 pm -
1 stop3h 55m
Thu 11/265:10 am -
2 stops6h 35m
Deal found 10/21![Southwest logo]()
$265
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/183:45 pm -
2 stops7h 20m
Sun 11/225:25 am -
1 stop3h 35m
Deal found 10/20![Southwest logo]()
$269
This Delta deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/196:30 am -
1 stop6h 26m
Sun 12/206:15 am -
1 stop3h 58m
Deal found 10/23![Delta logo]()
$287
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/307:00 am -
1 stop4h 46m
Sun 1/35:00 am -
1 stop7h 16m
Deal found 10/20![United Airlines logo]()
$328
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/48:18 pm -
1 stop20h 07m
Sun 11/83:27 pm -
2 stops27h 53m
Deal found 10/20![Multiple Airlines logo]()
$344
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/148:45 am -
1 stop8h 22m
Wed 11/186:05 am -
1 stop4h 22m
Deal found 10/22![United Airlines logo]()
$339
This Delta deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:00 am -
1 stop4h 49m
Sun 12/611:35 am -
1 stop5h 05m
Deal found 10/21![Delta logo]()
$324
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/183:45 pm -
2 stops7h 20m
Wed 11/255:40 pm -
1 stop6h 00m
Deal found 10/21![Southwest logo]()
$343
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/73:58 pm -
1 stop4h 18m
Wed 11/118:00 am -
1 stop4h 12m
Deal found 10/23![United Airlines logo]()
$369
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/226:35 pm -
2 stops6h 00m
Tue 12/295:10 am -
1 stop3h 45m
Deal found 10/23![Southwest logo]()
$364
This United Airlines deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:20 am -
1 stop6h 12m
Wed 11/118:00 am -
1 stop6h 24m
Deal found 10/23![United Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:36 pm -
1 stop6h 50m
Sun 11/157:26 pm -
1 stop15h 21m
Deal found 10/21![American Airlines logo]()
$525
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2012:35 pm -
2 stops10h 30m
Fri 11/275:25 am -
1 stop3h 45m
Deal found 10/21![Southwest logo]()
$368
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/297:59 pm -
1 stop13h 26m
Sun 11/111:17 am -
1 stop10h 41m
Deal found 10/21![Multiple Airlines logo]()
$491
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/711:03 am -
1 stop4h 22m
Sat 11/144:00 pm -
1 stop6h 05m
Deal found 10/24![Delta logo]()
$421
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/612:19 pm -
1 stop6h 09m
Tue 11/108:00 am -
1 stop4h 13m
Deal found 10/22![United Airlines logo]()
$383
This Delta deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1311:25 am -
1 stop6h 24m
Mon 11/165:29 pm -
1 stop4h 20m
Deal found 10/24![Delta logo]()
$421
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/97:55 pm -
1 stop4h 10m
Tue 11/177:00 am -
2 stops10h 25m
Deal found 10/20![Southwest logo]()
$388
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:20 am -
1 stop6h 12m
Mon 11/96:45 pm -
1 stop3h 57m
Deal found 10/21![United Airlines logo]()
$393
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/612:35 pm -
2 stops10h 30m
Tue 11/106:00 am -
1 stop3h 40m
Deal found 10/22![Southwest logo]()
$388
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/35:53 pm -
1 stop6h 21m
Sat 2/611:22 am -
1 stop4h 49m
Deal found 10/21![United Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/212:26 pm -
1 stop5h 50m
Sat 11/286:45 pm -
1 stop3h 53m
Deal found 10/24![United Airlines logo]()
$439
This Southwest deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:50 am -
2 stops18h 15m
Mon 11/167:00 am -
2 stops13h 25m
Deal found 10/24![Southwest logo]()
$482
This United Airlines deal was found by Cheapflights users on 10/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/147:10 am -
1 stop4h 22m
Wed 11/188:00 am -
1 stop4h 27m
Deal found 10/24![United Airlines logo]()
$439
Last-minute flights from Ohio to Des MoinesDiscover last-minute flight deals from Ohio to Des Moines. Data last updated October 25, 2026 and is based on user searches.
Discover last-minute flight deals from Ohio to Des Moines. Data last updated October 25, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/48:18 pm -
1 stop20h 07m
Sun 11/83:27 pm -
2 stops27h 53m
Deal found 10/20![Multiple Airlines logo]()
$344
This Kiwi.com deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/512:59 pm -
1 stop20h 22m
Mon 11/98:30 pm -
2 stops37h 49m
Deal found 10/21![Multiple Airlines logo]()
$331
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/95:56 pm -
1 stop4h 59m
Wed 11/118:00 am -
1 stop4h 10m
Deal found 10/20![United Airlines logo]()
$239
This American Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:59 pm -
1 stop4h 27m
Tue 11/179:25 am -
1 stop5h 53m
Deal found 10/20![American Airlines logo]()
$249
This United Airlines deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/149:04 am -
1 stop6h 20m
Wed 11/188:00 am -
1 stop4h 10m
Deal found 10/20![United Airlines logo]()
$339
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:10 am -
1 stop9h 05m
Sun 11/225:25 am -
1 stop3h 35m
Deal found 10/20![Southwest logo]()
$264
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/183:45 pm -
2 stops7h 20m
Wed 11/255:40 pm -
1 stop6h 00m
Deal found 10/21![Southwest logo]()
$343
This Southwest deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/197:10 pm -
1 stop3h 55m
Thu 11/265:10 am -
2 stops6h 35m
Deal found 10/21![Southwest logo]()
$265
This Delta deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:00 am -
1 stop5h 44m
Wed 11/256:52 pm -
1 stop4h 38m
Deal found 10/20![Delta logo]()
$291
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/207:42 pm -
1 stop4h 17m
Fri 11/276:45 pm -
1 stop4h 14m
Deal found 10/21![United Airlines logo]()
$315
This Southwest deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:00 am -
2 stops7h 10m
Tue 11/245:10 am -
1 stop3h 35m
Deal found 10/20![Southwest logo]()
$338
This United Airlines deal was found by Cheapflights users on 10/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/255:56 pm -
1 stop4h 59m
Mon 11/306:45 pm -
1 stop3h 59m
Deal found 10/21![United Airlines logo]()
$328
One-way flights from Ohio to Des MoinesSearch for one-way flight options from Ohio to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
Search for one-way flight options from Ohio to Des Moines. Find affordable one-way fares based on user searches. Data last updated October 25, 2026.
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:40 am -
1 stop4h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Delta logo]()
$120
This United Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1610:35 am -
2 stops9h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![United Airlines logo]()
$125
This American Airlines deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/89:04 pm -
1 stop4h 22m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![American Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/79:00 am -
1 stop27h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Allegiant Air logo]()
$132
This Delta deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1811:25 am -
1 stop6h 24m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Delta logo]()
$135
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/227:55 pm -
1 stop4h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Southwest logo]()
$145
This Southwest deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/186:55 am -
2 stops16h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Southwest logo]()
$151
This deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/115:56 pm -
1 stop6h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![United Airlines logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 10/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1812:36 pm -
3 stops45h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/22![Multiple Airlines logo]()
$180
This deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/296:05 am -
1 stop5h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/19![United Airlines logo]()
$185
This Kiwi.com deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/37:59 pm -
3 stops44h 26m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Multiple Airlines logo]()
$215
This Southwest deal was found by Cheapflights users on 10/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/75:55 am -
2 stops17h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/23![Southwest logo]()
$225
Find flight deals from Ohio to Des Moines
Keep the following information in mind while searching for Ohio to Des Moines flight deals. Data was last updated October 25, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $239 (United Airlines) |
One-way from | $120 (Delta) |
Popular in | June |
Cheapest in | April |
Average price | $381 |
Cheapflights Fare Finder
Customize your flight search to find flights from Ohio to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
Use the filters below to find and compare flights from Ohio to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ColumbusDes Moines
CMH Columbus - DSM Des Moines
CMHDSM
Columbus
Wed 12/16
6:40 am-10:21 am
1 stop4h 41m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$120
ColumbusDes Moines
CMH Columbus - DSM Des Moines
CMHDSM
Columbus
Wed 12/16
10:35 am-7:19 pm
2 stops9h 44m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$125
CincinnatiDes Moines
CVG Cincinnati Cinci./N. Kentucky - DSM Des Moines
CVGDSM
Cincinnati Cinci./N. Kentucky
Mon 12/7
9:00 am-11:38 am
1 stop27h 38m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$132
CincinnatiDes Moines
CVG Cincinnati Cinci./N. Kentucky - DSM Des Moines
CVGDSM
Cincinnati Cinci./N. Kentucky
Wed 11/18
11:25 am-4:49 pm
1 stop6h 24m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$135
Quickest round-trip
ClevelandDes Moines
CLE Cleveland Hopkins Intl - DSM Des Moines
CLEDSM
Cleveland Hopkins Intl
Sun 11/22
7:55 pm-11:05 pm
1 stop4h 10m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$145
CincinnatiDes Moines
CVG Cincinnati Cinci./N. Kentucky - DSM Des Moines
CVGDSM
Cincinnati Cinci./N. Kentucky
Wed 11/18
6:55 am-10:05 pm
2 stops16h 10m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$151
ColumbusDes Moines
CMH Columbus - DSM Des Moines
CMHDSM
Columbus
Wed 11/11
5:56 pm-9:55 pm
1 stop4h 59m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$191
CincinnatiDes Moines
CVG Cincinnati Cinci./N. Kentucky - DSM Des Moines
CVGDSM
Cincinnati Cinci./N. Kentucky
Tue 11/3
7:59 pm-3:25 pm
3 stops44h 26m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$215
CincinnatiDes Moines
CVG Cincinnati Cinci./N. Kentucky - DSM Des Moines
CVGDSM
Cincinnati Cinci./N. Kentucky
Mon 12/7
5:55 am-10:05 pm
2 stops17h 10m
Des Moines
Wed 12/31
12:00 am-1:00 am
Nonstop0h 00m
$225
ColumbusDes Moines
CMH Columbus - DSM Des Moines
CMHDSM
Columbus
Tue 12/29
5:54 pm-8:45 pm
1 stop3h 51m
Des Moines
Mon 1/4
5:15 pm-12:10 am
1 stop5h 55m
$239
Showing 1-10 of 46 resultsSorted by cheapest first
Best time to book a flight from Ohio to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Ohio with our price prediction graph.
CMH-DSM
CVG-DSM
CLE-DSM
CAK-DSM
DAY-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Ohio to Des Moines
USOH-DSM
CMH-DSM
CVG-DSM
CLE-DSM
CAK-DSM
What is the cheapest month to book a flight from Ohio to Des Moines?
Currently, December is the cheapest month in which you can book a flight from Ohio to Des Moines (average of $360). Flying from Ohio to Des Moines in January is currently the most expensive (average of $577). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Ohio to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Clive
West Des Moines
Ames
Johnston
Boone
Norwalk
Ankeny
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Ohio to Des Moines
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Complete your trip
Complete your trip to Des Moines by adding a car rental and/or hotel reservation to your travel itinerary.
Other flights to Des Moines
Explore flights to Des Moines departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 25, 2026.
Search flights from Ohio to Des Moines by cabin class
Find flights from Ohio to Des Moines, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Ohio and Des Moines flights
Browse other Ohio and Des Moines flight options. Last updated on October 25, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Ohio to Des Moines flights
Consider these flights traveling from Ohio to Des Moines.
Top 4 airlines flying from Ohio to Des Moines
Discover the top 4 airlines that operate flights from Ohio to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$424 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$269 | Average$444 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$296 | Average$450 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$302 | Average$411 | FlexibilityNo cancel fee | On-time63% |