HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Des Moines

$142+ Cheap flights from Mississippi to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/10. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — DSM
Jul 6 — Jul 131
Sun 7/6
Sun 7/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Mississippi to Des Moines with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Mississippi to Des Moines

Keep the following information in mind while searching for Mississippi to Des Moines flight deals. Data was last updated July 1, 2025.

Round-trip from

$249
(American Airlines)

One-way from

$142
(Mytrip)
From Mississippi to Des Moines
Search Deals
One-way flight from Mississippi to Des Moines
Search Deals

Find flight deals from Mississippi to Des Moines

Cheapest flights from Mississippi to Des Moines
Explore the most affordable flight options available from Mississippi to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/146:30 pmGPT - DSM
1 stop5h 15mAmerican Airlines
Mon 8/185:29 pmDSM - GPT
1 stop4h 55mAmerican Airlines
Deal found 6/30$249
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/185:59 pmMOB - DSM
1 stop4h 34mDelta
Wed 7/235:30 amDSM - MOB
1 stop6h 30mDelta
Deal found 6/30$254
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1612:28 pmMOB - DSM
1 stop6h 11mAmerican Airlines
Sun 7/207:09 amDSM - MOB
1 stop5h 10mAmerican Airlines
Deal found 6/30$259
This Delta deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/56:00 amGTR - DSM
1 stop4h 39mDelta
Wed 8/62:29 pmDSM - GTR
1 stop7h 06mDelta
Deal found 6/29$326
This Mytrip deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/138:42 pmMEM - DSM
1 stop11h 58mMultiple Airlines
Sun 7/2010:31 pmDSM - MEM
2 stops17h 58mMultiple Airlines
Deal found 7/1$332
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/246:21 pmBTR - DSM
1 stop5h 28mAmerican Airlines
Tue 8/123:49 pmDSM - BTR
1 stop4h 22mAmerican Airlines
Deal found 6/30$348
This American Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/167:33 pmMEM - DSM
1 stop4h 16mAmerican Airlines
Sun 7/205:17 pmDSM - MEM
1 stop6h 41mAmerican Airlines
Deal found 7/1$367
This Mytrip deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/108:48 pmMEM - DSM
1 stop11h 52mAllegiant Air
Sun 7/136:32 pmDSM - MEM
2 stops20h 42mAllegiant Air
Deal found 6/30$412
This United Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/88:58 amMEI - DSM
1 stop5h 13mUnited Airlines
Tue 11/112:52 pmDSM - MEI
1 stop5h 28mUnited Airlines
Deal found 6/29$414
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/105:20 amMEM - DSM
1 stop5h 19mDelta
Sun 7/135:30 amDSM - MEM
1 stop6h 08mDelta
Deal found 6/30$447
This United Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/245:10 amBTR - DSM
2 stops9h 31mUnited Airlines
Tue 8/126:00 amDSM - BTR
2 stops9h 27mUnited Airlines
Deal found 6/30$483
This Southwest deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/135:10 amMEM - DSM
2 stops6h 05mSouthwest
Sun 7/206:00 amDSM - MEM
2 stops5h 55mSouthwest
Deal found 7/1$486

Cheapflights Fare Finder

Customize your flight search to find flights from Mississippi to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
Use the filters below to find and compare flights from Mississippi to Des Moines that are best for you.

Fly from

Mississippi

Fly to

Des Moines

Route

Depart

Return

Price

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

Thu 8/14

6:30 pm-11:45 pm

1 stop5h 15m

Des Moines

Mon 8/18

5:29 pm-10:24 pm

1 stop4h 55m

$249

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Fri 7/18

5:59 pm-10:33 pm

1 stop4h 34m

Des Moines

Wed 7/23

5:30 am-12:00 pm

1 stop6h 30m

$254

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Wed 7/16

12:28 pm-6:39 pm

1 stop6h 11m

Des Moines

Sun 7/20

7:09 am-12:19 pm

1 stop5h 10m

$259

ColumbusDes Moines

GTR - DSM

GTRDSM

Columbus Golden Triangle Reg.

Tue 8/5

6:00 am-10:39 am

1 stop4h 39m

Des Moines

Wed 8/6

2:29 pm-9:35 pm

1 stop7h 06m

$326

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sun 7/13

8:42 pm-8:40 am

1 stop11h 58m

Des Moines

Sun 7/20

10:31 pm-4:29 pm

2 stops17h 58m

$332

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Thu 7/24

6:21 pm-11:49 pm

1 stop5h 28m

Des Moines

Tue 8/12

3:49 pm-8:11 pm

1 stop4h 22m

$348

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Wed 7/16

7:33 pm-11:49 pm

1 stop4h 16m

Des Moines

Sun 7/20

5:17 pm-11:58 pm

1 stop6h 41m

$367

MeridianDes Moines

MEI - DSM

MEIDSM

Meridian Key Field

Sat 11/8

8:58 am-2:11 pm

1 stop5h 13m

Des Moines

Tue 11/11

2:52 pm-8:20 pm

1 stop5h 28m

$414

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Thu 7/24

5:10 am-2:41 pm

2 stops9h 31m

Des Moines

Tue 8/12

6:00 am-3:27 pm

2 stops9h 27m

$483

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sun 7/13

5:10 am-11:15 am

2 stops6h 05m

Des Moines

Sun 7/20

6:00 am-11:55 am

2 stops5h 55m

$486

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/1

Showing 1-10 of 18 results
1
2

Best time to book a flight from Mississippi to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Des Moines
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated July 1, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Mississippi to Des Moines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,273 reviews

Comfort

8.0

Entertainment

7.6

Overall

8.0

Boarding

8.2

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,273 reviews
Southwest
8.0
Very good
4,273 reviews

Comfort

8.0

Entertainment

7.6

Overall

8.0

Boarding

8.2

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,973 reviews
Southwest
8.0
Very good
4,273 reviews

Comfort

8.0

Entertainment

7.6

Overall

8.0

Boarding

8.2

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,858 reviews
Southwest
8.0
Very good
4,273 reviews

Comfort

8.0

Entertainment

7.6

Overall

8.0

Boarding

8.2

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,273 reviews

Comfort

8.0

Entertainment

7.6

Overall

8.0

Boarding

8.2

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Allegiant Air
7.2
Good
710 reviews
Southwest
8.0
Very good
4,273 reviews

Comfort

8.0

Entertainment

7.6

Overall

8.0

Boarding

8.2

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mississippi?

    Des Moines (DSM) is the airport you will fly into if you book a flight from Mississippi to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • What are the most popular routes from Mississippi to Des Moines?

    The most popular flight routes from Mississippi to Des Moines are Memphis - Des Moines, Mobile - Des Moines and Gulfport Biloxi Regional - Des Moines.

  • Can I find deals for flights from Mississippi to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mississippi to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Des Moines.

  • Can I find deals for business class flights from Mississippi to Des Moines?

    Yes. Cheapflights offers flight deals from Mississippi to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Mississippi to Des Moines (average of $336). Flying from Mississippi to Des Moines in June is currently the most expensive (average of $405). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Mississippi?

Book flights to Mississippi if you plan to visit one of these locations
Altoona
Ames
Johnston
Boone
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Mississippi to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
Dallas/Fort Worth to Omaha flights
LaGuardia to Omaha flights
Denver to Cedar Rapids flights
John F Kennedy Intl to Omaha flights
O'Hare Intl to Omaha flights
Seattle to Des Moines flights
Seattle to Omaha flights
Newark to Omaha flights
Denver to Des Moines flights
Los Angeles to Des Moines flights
John F Kennedy Intl to Des Moines flights
Sky Harbor Intl to Des Moines flights
Dulles Intl to Omaha flights
Denver to Omaha flights
Reagan-National to Omaha flights
Reagan-National to Des Moines flights
Los Angeles to Omaha flights
LaGuardia to Des Moines flights
Dulles Intl to Des Moines flights
Baltimore to Omaha flights
Atlanta to Omaha flights
Hobby to Des Moines flights
Sky Harbor Intl to Cedar Rapids flights
San Francisco to Omaha flights
Dallas/Fort Worth to Des Moines flights
Seattle to Cedar Rapids flights
O'Hare Intl to Des Moines flights
George Bush Intcntl to Des Moines flights
Philadelphia to Omaha flights
Atlanta to Des Moines flights
Tampa to Omaha flights
LaGuardia to Cedar Rapids flights
Austin to Omaha flights
Baltimore to Des Moines flights
Sky Harbor Intl to Omaha flights
Newark to Cedar Rapids flights
Dallas/Fort Worth to Cedar Rapids flights
Love Field to Omaha flights
Dayton to Des Moines flights
John F Kennedy Intl to Cedar Rapids flights
Denver to Moline flights
Detroit to Omaha flights
Portland to Omaha flights
San Francisco to Cedar Rapids flights
Boston to Omaha flights
Hartford to Cedar Rapids flights
Orlando to Des Moines flights
Midway to Omaha flights
Dulles Intl to Cedar Rapids flights
George Bush Intcntl to Omaha flights

Top 2 airlines flying from Mississippi to Des Moines

Discover the top 2 airlines that operate flights from Mississippi to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$200Average$254FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$205Average$340FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.