$339+ Cheap flights from Des Moines (DSM) to Mississippi
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JAN
Nov 12 — Nov 191
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to MississippiExplore the most affordable flight options available from Des Moines to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 13, 2026.
Explore the most affordable flight options available from Des Moines to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 13, 2026.
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1011:38 am -
1 stop5h 22m
Mon 12/146:23 pm -
1 stop4h 42m
Deal found 10/8![American Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
1 stop5h 45m
Sun 11/155:00 am -
1 stop5h 48m
Deal found 10/12![American Airlines logo]()
$341
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:25 am -
2 stops14h 20m
Thu 11/191:10 pm -
2 stops8h 55m
Deal found 10/8![Southwest logo]()
$343
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:01 pm -
1 stop6h 58m
Sat 11/146:50 am -
1 stop7h 30m
Deal found 10/8![United Airlines logo]()
$357
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1211:28 am -
1 stop7h 51m
Thu 11/196:30 pm -
1 stop5h 56m
Deal found 10/8![American Airlines logo]()
$363
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:00 am -
1 stop5h 50m
Sat 10/316:02 pm -
1 stop5h 05m
Deal found 10/12![American Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/273:03 pm -
1 stop7h 13m
Sat 10/316:26 am -
2 stops7h 59m
Deal found 10/12![Delta logo]()
$374
This Delta deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/124:27 pm -
1 stop4h 26m
Sun 12/136:15 am -
1 stop4h 34m
Deal found 10/10![Delta logo]()
$384
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/133:31 pm -
1 stop7h 21m
Thu 11/196:30 pm -
1 stop5h 56m
Deal found 10/8![American Airlines logo]()
$392
This Southwest deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
2 stops11h 35m
Sun 11/155:40 am -
2 stops7h 30m
Deal found 10/12![Southwest logo]()
$429
This Delta deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/124:27 pm -
1 stop4h 26m
Mon 12/146:09 pm -
1 stop4h 29m
Deal found 10/10![Delta logo]()
$438
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:02 pm -
1 stop4h 36m
Tue 10/205:14 pm -
1 stop5h 01m
Deal found 10/8![United Airlines logo]()
$444
Best flights from Des Moines to MississippiDiscover carefully curated flight deals from Des Moines to Mississippi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 13, 2026.
Discover carefully curated flight deals from Des Moines to Mississippi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 13, 2026.
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:25 am -
2 stops14h 20m
Thu 11/191:10 pm -
2 stops8h 55m
Deal found 10/8![Southwest logo]()
$343
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:01 pm -
1 stop6h 58m
Sat 11/146:50 am -
1 stop7h 30m
Deal found 10/8![United Airlines logo]()
$357
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1211:28 am -
1 stop7h 51m
Thu 11/196:30 pm -
1 stop5h 56m
Deal found 10/8![American Airlines logo]()
$363
This Delta deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/124:27 pm -
1 stop4h 26m
Sun 12/136:15 am -
1 stop4h 34m
Deal found 10/10![Delta logo]()
$384
This Kiwi.com deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/63:26 pm -
1 stop20h 44m
Sun 11/83:20 pm -
1 stop19h 30m
Deal found 10/12![Multiple Airlines logo]()
$601
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/133:31 pm -
1 stop7h 21m
Thu 11/196:30 pm -
1 stop5h 56m
Deal found 10/8![American Airlines logo]()
$392
This United Airlines deal was found by Cheapflights users on 10/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/268:00 am -
1 stop5h 24m
Sat 1/304:55 pm -
1 stop5h 35m
Deal found 10/10![United Airlines logo]()
$439
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/39:25 am -
2 stops10h 08m
Sat 2/64:55 pm -
1 stop5h 35m
Deal found 10/12![United Airlines logo]()
$464
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/108:00 am -
2 stops8h 08m
Mon 12/145:05 pm -
1 stop5h 16m
Deal found 10/8![United Airlines logo]()
$469
Last-minute flights from Des Moines to MississippiDiscover last-minute flight deals from Des Moines to Mississippi. Data last updated October 13, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mississippi. Data last updated October 13, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/133:02 pm -
1 stop4h 36m
Tue 10/205:14 pm -
1 stop5h 01m
Deal found 10/8![United Airlines logo]()
$444
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:00 am -
2 stops11h 04m
Tue 10/206:41 am -
1 stop5h 42m
Deal found 10/8![American Airlines logo]()
$493
This Delta deal was found by Cheapflights users on 10/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:00 am -
2 stops7h 01m
Tue 10/206:26 am -
2 stops10h 29m
Deal found 10/11![Delta logo]()
$509
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/277:00 am -
1 stop5h 50m
Sat 10/316:02 pm -
1 stop5h 05m
Deal found 10/12![American Airlines logo]()
$369
This Delta deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/273:03 pm -
1 stop7h 13m
Sat 10/316:26 am -
2 stops7h 59m
Deal found 10/12![Delta logo]()
$374
This United Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:01 pm -
1 stop6h 58m
Sat 11/146:50 am -
1 stop7h 30m
Deal found 10/8![United Airlines logo]()
$357
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
1 stop5h 45m
Sun 11/155:00 am -
1 stop5h 48m
Deal found 10/12![American Airlines logo]()
$341
This Southwest deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:00 am -
2 stops11h 35m
Sun 11/155:40 am -
2 stops7h 30m
Deal found 10/12![Southwest logo]()
$429
This Southwest deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/125:25 am -
2 stops14h 20m
Thu 11/191:10 pm -
2 stops8h 55m
Deal found 10/8![Southwest logo]()
$343
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1211:28 am -
1 stop7h 51m
Thu 11/196:30 pm -
1 stop5h 56m
Deal found 10/8![American Airlines logo]()
$363
This American Airlines deal was found by Cheapflights users on 10/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/133:31 pm -
1 stop7h 21m
Thu 11/196:30 pm -
1 stop5h 56m
Deal found 10/8![American Airlines logo]()
$392
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/2211:28 am -
1 stop5h 49m
Fri 11/275:49 pm -
1 stop6h 37m
Deal found 10/12![American Airlines logo]()
$529
Find flight deals from Des Moines to Mississippi
Keep the following information in mind while searching for Des Moines to Mississippi flight deals. Data was last updated October 13, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $339 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 13, 2026.
Use the filters below to find and compare flights from Des Moines to Mississippi that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesJackson
DSM Des Moines - JAN Jackson-Evers Intl
DSMJAN
Des Moines
Thu 11/12
5:25 am-7:45 pm
2 stops14h 20m
Jackson-Evers Intl
Thu 11/19
1:10 pm-10:05 pm
2 stops8h 55m
$343
Des MoinesJackson
DSM Des Moines - JAN Jackson-Evers Intl
DSMJAN
Des Moines
Tue 11/10
3:01 pm-9:59 pm
1 stop6h 58m
Jackson-Evers Intl
Sat 11/14
6:50 am-2:20 pm
1 stop7h 30m
$357
Des MoinesJackson
DSM Des Moines - JAN Jackson-Evers Intl
DSMJAN
Des Moines
Thu 11/12
11:28 am-7:19 pm
1 stop7h 51m
Jackson-Evers Intl
Thu 11/19
6:30 pm-12:26 am
1 stop5h 56m
$363
Quickest round-trip
Des MoinesGulfport
DSM Des Moines - GPT Gulfport Biloxi Regional
DSMGPT
Des Moines
Sat 12/12
4:27 pm-8:53 pm
1 stop4h 26m
Gulfport Biloxi Regional
Sun 12/13
6:15 am-10:49 am
1 stop4h 34m
$384
Des MoinesJackson
DSM Des Moines - JAN Jackson-Evers Intl
DSMJAN
Des Moines
Fri 11/13
3:31 pm-10:52 pm
1 stop7h 21m
Jackson-Evers Intl
Thu 11/19
6:30 pm-12:26 am
1 stop5h 56m
$392
Des MoinesGulfport
DSM Des Moines - GPT Gulfport Biloxi Regional
DSMGPT
Des Moines
Tue 1/26
8:00 am-1:24 pm
1 stop5h 24m
Gulfport Biloxi Regional
Sat 1/30
4:55 pm-10:30 pm
1 stop5h 35m
$439
Des MoinesGulfport
DSM Des Moines - GPT Gulfport Biloxi Regional
DSMGPT
Des Moines
Wed 2/3
9:25 am-7:33 pm
2 stops10h 08m
Gulfport Biloxi Regional
Sat 2/6
4:55 pm-10:30 pm
1 stop5h 35m
$464
Des MoinesGulfport
DSM Des Moines - GPT Gulfport Biloxi Regional
DSMGPT
Des Moines
Thu 12/10
8:00 am-4:08 pm
2 stops8h 08m
Gulfport Biloxi Regional
Mon 12/14
5:05 pm-10:21 pm
1 stop5h 16m
$469
Des MoinesTupelo
DSM Des Moines - TUP Tupelo Lemons Municipal
DSMTUP
Des Moines
Fri 11/6
3:26 pm-12:10 pm
1 stop20h 44m
Tupelo Lemons Municipal
Sun 11/8
3:20 pm-10:50 am
1 stop19h 30m
$601
Sorted by cheapest first
Best time to book a flight from Des Moines to Mississippi
Have a flexible travel schedule? Discover the best time to fly to Mississippi from Des Moines with our price prediction graph.
DSM-JAN
DSM-GPT
DSM-TUP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mississippi
DSM-USMS
DSM-JAN
DSM-GPT
DSM-TUP
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Mississippi
Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated October 13, 2026.
Peruse reviews from past customers who have flown with American Airlines from Des Moines to Mississippi to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Food
6.4
Comfort
7.2
Entertainment
6.8
Overall
7.0
Boarding
7.4
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Crew
7.9
Food
6.4
Comfort
7.2
Entertainment
6.8
Overall
7.0
Boarding
7.4
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Mississippi
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Complete your trip
Complete your trip to Mississippi by adding a car rental and/or hotel reservation to your travel itinerary.
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Des Moines and Mississippi flights
Browse other Des Moines and Mississippi flight options. Last updated on October 13, 2026.
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Des Moines to Mississippi flights
Consider these flights traveling from Des Moines to Mississippi.
Top airline flying from Des Moines to Mississippi
Discover the top airline that operate flights from Des Moines to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 13, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$366 | Average$696 | FlexibilityNo cancel fee | On-time71% |