$137+ Cheap flights from Des Moines (DSM) to Mississippi
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/8. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JAN
Aug 15 — Aug 221
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Des Moines to Mississippi with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Mississippi
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to MississippiExplore the most affordable flight options available from Des Moines to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 16, 2026.
Explore the most affordable flight options available from Des Moines to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 16, 2026.
This American Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:10 pm
DSM
- MEM
1 stop5h 40m
American Airlines
Mon 8/3111:21 am
MEM
- DSM
1 stop7h 20m
American Airlines
Deal found 7/11![American Airlines logo]()
$273
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/243:50 pm
DSM
- MEM
1 stop6h 35m
Southwest
Mon 8/3112:20 pm
MEM
- DSM
2 stops9h 50m
Southwest
Deal found 7/15![Southwest logo]()
$278
This American Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/77:49 pm
DSM
- MEM
1 stop5h 04m
American Airlines
Mon 9/145:40 pm
MEM
- DSM
1 stop5h 33m
American Airlines
Deal found 7/12![American Airlines logo]()
$281
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:40 pm
DSM
- MEM
2 stops7h 05m
Southwest
Wed 8/199:55 am
MEM
- DSM
2 stops11h 05m
Southwest
Deal found 7/15![Southwest logo]()
$283
This Southwest deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:50 am
DSM
- MEM
2 stops8h 35m
Southwest
Sat 10/101:35 pm
MEM
- DSM
1 stop7h 10m
Southwest
Deal found 7/12![Southwest logo]()
$284
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/92:15 pm
DSM
- AEX
1 stop7h 23m
Delta
Wed 12/166:00 am
AEX
- DSM
1 stop7h 27m
Delta
Deal found 7/12![Delta logo]()
$298
This Delta deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:40 am
DSM
- AEX
1 stop5h 19m
Delta
Wed 8/1911:44 am
AEX
- DSM
2 stops8h 55m
Delta
Deal found 7/16![Delta logo]()
$304
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:39 pm
DSM
- MOB
1 stop7h 11m
American Airlines
Tue 11/176:22 pm
MOB
- DSM
1 stop5h 59m
American Airlines
Deal found 7/13![American Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/255:40 am
DSM
- BTR
1 stop7h 07m
Delta
Tue 9/16:07 am
BTR
- DSM
1 stop4h 36m
Delta
Deal found 7/11![Delta logo]()
$309
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/264:10 pm
DSM
- GPT
1 stop4h 39m
Delta
Tue 9/296:25 am
GPT
- DSM
1 stop7h 24m
Delta
Deal found 7/15![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:20 am
DSM
- MEM
1 stop7h 50m
Southwest
Sun 10/45:10 am
MEM
- DSM
1 stop6h 10m
Southwest
Deal found 7/15![Southwest logo]()
$310
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:15 am
DSM
- MOB
1 stop5h 36m
United Airlines
Tue 9/2910:50 am
MOB
- DSM
2 stops10h 33m
United Airlines
Deal found 7/15![United Airlines logo]()
$314
Best flights from Des Moines to MississippiDiscover carefully curated flight deals from Des Moines to Mississippi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 16, 2026.
Discover carefully curated flight deals from Des Moines to Mississippi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 16, 2026.
This Southwest deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:25 pm
DSM
- MEM
1 stop7h 05m
Southwest
Thu 9/35:15 am
MEM
- DSM
1 stop6h 10m
Southwest
Deal found 7/13![Southwest logo]()
$273
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/128:00 am
DSM
- MEM
1 stop6h 46m
United Airlines
Wed 8/197:15 am
MEM
- DSM
1 stop7h 01m
United Airlines
Deal found 7/15![United Airlines logo]()
$273
This American Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:10 pm
DSM
- MEM
1 stop5h 40m
American Airlines
Mon 8/3111:21 am
MEM
- DSM
1 stop7h 20m
American Airlines
Deal found 7/11![American Airlines logo]()
$273
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/92:15 pm
DSM
- AEX
1 stop7h 23m
Delta
Wed 12/166:00 am
AEX
- DSM
1 stop7h 27m
Delta
Deal found 7/12![Delta logo]()
$298
This Southwest deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/243:50 pm
DSM
- MEM
1 stop6h 35m
Southwest
Mon 8/3112:20 pm
MEM
- DSM
2 stops9h 50m
Southwest
Deal found 7/11![Southwest logo]()
$278
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/15:40 am
DSM
- MOB
1 stop5h 37m
Delta
Sat 11/76:00 am
MOB
- DSM
1 stop4h 42m
Delta
Deal found 7/15![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:40 am
DSM
- MEM
2 stops10h 30m
Southwest
Wed 8/1912:25 pm
MEM
- DSM
2 stops9h 30m
Southwest
Deal found 7/14![Southwest logo]()
$283
This Delta deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2511:28 am
DSM
- MOB
1 stop4h 22m
Delta
Tue 9/15:00 pm
MOB
- DSM
1 stop5h 37m
Delta
Deal found 7/11![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:40 pm
DSM
- MEM
2 stops7h 05m
Southwest
Wed 8/199:55 am
MEM
- DSM
2 stops11h 05m
Southwest
Deal found 7/15![Southwest logo]()
$283
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/141:24 pm
DSM
- MOB
2 stops8h 14m
United Airlines
Tue 10/204:58 pm
MOB
- DSM
1 stop5h 17m
United Airlines
Deal found 7/15![United Airlines logo]()
$359
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/154:30 pm
DSM
- MEM
1 stop7h 25m
Southwest
Sat 10/1712:05 pm
MEM
- DSM
2 stops8h 40m
Southwest
Deal found 7/15![Southwest logo]()
$284
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2610:23 am
DSM
- GPT
2 stops11h 58m
Delta
Wed 9/24:00 pm
GPT
- DSM
1 stop6h 37m
Delta
Deal found 7/12![Delta logo]()
$314
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2210:20 am
DSM
- GPT
2 stops11h 48m
Delta
Tue 9/291:56 pm
GPT
- DSM
1 stop4h 13m
Delta
Deal found 7/15![Delta logo]()
$314
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:15 am
DSM
- MOB
1 stop5h 36m
United Airlines
Sat 8/229:00 am
MOB
- DSM
1 stop5h 14m
United Airlines
Deal found 7/13![United Airlines logo]()
$389
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:20 am
DSM
- MEM
1 stop7h 50m
Southwest
Sun 10/45:10 am
MEM
- DSM
1 stop6h 10m
Southwest
Deal found 7/15![Southwest logo]()
$310
This Delta deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:00 am
DSM
- BTR
2 stops12h 31m
Delta
Tue 9/11:27 pm
BTR
- DSM
2 stops7h 12m
Delta
Deal found 7/11![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:15 am
DSM
- BTR
1 stop7h 01m
United Airlines
Sat 8/297:15 am
BTR
- DSM
1 stop6h 59m
United Airlines
Deal found 7/14![United Airlines logo]()
$389
This Southwest deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:50 am
DSM
- MEM
2 stops8h 35m
Southwest
Sat 10/1012:05 pm
MEM
- DSM
2 stops8h 40m
Southwest
Deal found 7/12![Southwest logo]()
$318
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:21 am
DSM
- AEX
2 stops9h 07m
United Airlines
Sat 10/319:45 am
AEX
- DSM
2 stops10h 44m
United Airlines
Deal found 7/15![United Airlines logo]()
$389
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/282:54 pm
DSM
- BTR
1 stop7h 07m
Delta
Fri 9/43:57 pm
BTR
- DSM
1 stop6h 40m
Delta
Deal found 7/14![Delta logo]()
$334
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/85:00 am
DSM
- MOB
2 stops11h 09m
United Airlines
Sat 12/125:10 pm
MOB
- DSM
1 stop5h 20m
United Airlines
Deal found 7/15![United Airlines logo]()
$394
This Delta deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2210:20 am
DSM
- GPT
2 stops11h 48m
Delta
Wed 9/301:56 pm
GPT
- DSM
2 stops6h 50m
Delta
Deal found 7/15![Delta logo]()
$343
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:21 am
DSM
- MOB
2 stops12h 17m
United Airlines
Tue 11/174:59 pm
MOB
- DSM
1 stop5h 26m
United Airlines
Deal found 7/15![United Airlines logo]()
$394
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:40 am
DSM
- JAN
1 stop6h 39m
Delta
Sun 11/85:45 am
JAN
- DSM
1 stop4h 57m
Delta
Deal found 7/12![Delta logo]()
$345
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/286:20 am
DSM
- BTR
1 stop5h 00m
United Airlines
Sat 8/14:09 pm
BTR
- DSM
1 stop6h 26m
United Airlines
Deal found 7/13![United Airlines logo]()
$394
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/194:10 pm
DSM
- MOB
1 stop4h 34m
Delta
Mon 9/214:37 pm
MOB
- DSM
1 stop5h 52m
Delta
Deal found 7/12![Delta logo]()
$354
This United Airlines deal was found by Cheapflights users on 7/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:21 am
DSM
- GPT
2 stops9h 46m
United Airlines
Wed 11/185:04 pm
GPT
- DSM
1 stop5h 21m
United Airlines
Deal found 7/10![United Airlines logo]()
$394
This United Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/72:56 pm
DSM
- MOB
1 stop7h 04m
United Airlines
Fri 11/1310:30 am
MOB
- DSM
2 stops11h 05m
United Airlines
Deal found 7/14![United Airlines logo]()
$403
This United Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:45 am
DSM
- JAN
2 stops10h 40m
United Airlines
Wed 10/287:00 am
JAN
- DSM
2 stops9h 09m
United Airlines
Deal found 7/13![United Airlines logo]()
$404
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:00 am
DSM
- GPT
2 stops7h 11m
Delta
Tue 9/155:59 pm
GPT
- DSM
1 stop4h 30m
Delta
Deal found 7/13![Delta logo]()
$422
Last-minute flights from Des Moines to MississippiDiscover last-minute flight deals from Des Moines to Mississippi. Data last updated July 16, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mississippi. Data last updated July 16, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:22 pm
DSM
- MEM
1 stop4h 28m
American Airlines
Mon 8/105:44 pm
MEM
- DSM
1 stop6h 36m
American Airlines
Deal found 7/13![American Airlines logo]()
$330
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:40 pm
DSM
- MEM
2 stops7h 05m
Southwest
Wed 8/199:55 am
MEM
- DSM
2 stops11h 05m
Southwest
Deal found 7/15![Southwest logo]()
$283
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/124:13 pm
DSM
- GPT
1 stop7h 03m
American Airlines
Tue 8/186:34 pm
GPT
- DSM
1 stop4h 51m
American Airlines
Deal found 7/13![American Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:22 pm
DSM
- MEM
1 stop4h 28m
American Airlines
Sun 8/165:44 pm
MEM
- DSM
1 stop6h 36m
American Airlines
Deal found 7/14![American Airlines logo]()
$310
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:00 am
DSM
- GPT
2 stops7h 03m
Delta
Tue 8/186:00 pm
GPT
- DSM
1 stop4h 37m
Delta
Deal found 7/13![Delta logo]()
$338
This Delta deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:40 am
DSM
- AEX
1 stop5h 19m
Delta
Wed 8/1911:44 am
AEX
- DSM
2 stops8h 55m
Delta
Deal found 7/16![Delta logo]()
$304
This American Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/245:10 pm
DSM
- MEM
1 stop5h 40m
American Airlines
Mon 8/3111:21 am
MEM
- DSM
1 stop7h 20m
American Airlines
Deal found 7/11![American Airlines logo]()
$273
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/243:50 pm
DSM
- MEM
1 stop6h 35m
Southwest
Mon 8/3112:20 pm
MEM
- DSM
2 stops9h 50m
Southwest
Deal found 7/15![Southwest logo]()
$278
This Delta deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2511:28 am
DSM
- MOB
1 stop4h 22m
Delta
Tue 9/15:00 pm
MOB
- DSM
1 stop5h 37m
Delta
Deal found 7/11![Delta logo]()
$309
This Delta deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/255:40 am
DSM
- BTR
1 stop7h 07m
Delta
Tue 9/16:07 am
BTR
- DSM
1 stop4h 36m
Delta
Deal found 7/11![Delta logo]()
$309
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2610:23 am
DSM
- GPT
2 stops11h 58m
Delta
Wed 9/24:00 pm
GPT
- DSM
1 stop6h 37m
Delta
Deal found 7/12![Delta logo]()
$314
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/282:54 pm
DSM
- BTR
1 stop7h 07m
Delta
Fri 9/43:57 pm
BTR
- DSM
1 stop6h 40m
Delta
Deal found 7/14![Delta logo]()
$334
One-way flights from Des Moines to MississippiSearch for one-way flight options from Des Moines to Mississippi. Find affordable one-way fares based on user searches. Data last updated July 16, 2026.
Search for one-way flight options from Des Moines to Mississippi. Find affordable one-way fares based on user searches. Data last updated July 16, 2026.
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/272:45 pm
DSM
- MEM
1 stop7h 26m
Delta
Deal found 7/13![Delta logo]()
$137
This American Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/47:13 pm
DSM
- MEM
1 stop4h 51m
American Airlines
Deal found 7/11![American Airlines logo]()
$138
This Southwest deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/42:40 pm
DSM
- MEM
2 stops7h 05m
Southwest
Deal found 7/11![Southwest logo]()
$142
This American Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/77:49 pm
DSM
- MEM
1 stop5h 04m
American Airlines
Deal found 7/12![American Airlines logo]()
$145
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:40 am
DSM
- MEM
2 stops15h 20m
Southwest
Deal found 7/14![Southwest logo]()
$153
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/812:25 pm
DSM
- MEM
2 stops30h 53m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$172
This American Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:58 pm
DSM
- MEM
1 stop4h 24m
American Airlines
Deal found 7/14![American Airlines logo]()
$174
This American Airlines deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/37:13 pm
DSM
- MEM
1 stop4h 51m
American Airlines
Deal found 7/11![American Airlines logo]()
$194
This American Airlines deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:00 am
DSM
- BTR
1 stop4h 52m
American Airlines
Deal found 7/14![American Airlines logo]()
$209
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/182:25 pm
DSM
- MEM
2 stops7h 30m
Southwest
Deal found 7/14![Southwest logo]()
$209
This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/158:03 am
DSM
- GPT
1 stop5h 09m
American Airlines
Deal found 7/13![American Airlines logo]()
$209
This United Airlines deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/298:00 am
DSM
- BTR
2 stops9h 34m
United Airlines
Deal found 7/15![United Airlines logo]()
$214
Find flight deals from Des Moines to Mississippi
Keep the following information in mind while searching for Des Moines to Mississippi flight deals. Data was last updated July 16, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $227 (American Airlines) |
One-way from | $114 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 16, 2026.
Use the filters below to find and compare flights from Des Moines to Mississippi that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesMemphis
DSM - MEM
DSMMEM
Des Moines
Thu 8/27
2:25 pm-9:30 pm
1 stop7h 05m
Memphis
Thu 9/3
5:15 am-11:25 am
1 stop6h 10m
$273
Des MoinesMemphis
DSM - MEM
DSMMEM
Des Moines
Wed 8/12
8:00 am-2:46 pm
1 stop6h 46m
Memphis
Wed 8/19
7:15 am-2:16 pm
1 stop7h 01m
$273
Des MoinesMemphis
DSM - MEM
DSMMEM
Des Moines
Mon 8/24
5:10 pm-10:50 pm
1 stop5h 40m
Memphis
Mon 8/31
11:21 am-6:41 pm
1 stop7h 20m
$273
Des MoinesMemphis
DSM - MEM
DSMMEM
Des Moines
Mon 8/24
3:50 pm-10:25 pm
1 stop6h 35m
Memphis
Mon 8/31
12:20 pm-10:10 pm
2 stops9h 50m
$278
Des MoinesMemphis
DSM - MEM
DSMMEM
Des Moines
Thu 8/13
5:40 am-4:10 pm
2 stops10h 30m
Memphis
Wed 8/19
12:25 pm-9:55 pm
2 stops9h 30m
$283
Des MoinesMemphis
DSM - MEM
DSMMEM
Des Moines
Wed 8/12
2:40 pm-9:45 pm
2 stops7h 05m
Memphis
Wed 8/19
9:55 am-9:00 pm
2 stops11h 05m
$283
Des MoinesMemphis
DSM - MEM
DSMMEM
Des Moines
Thu 10/15
4:30 pm-11:55 pm
1 stop7h 25m
Memphis
Sat 10/17
12:05 pm-8:45 pm
2 stops8h 40m
$284
Des MoinesAlexandria
DSM - AEX
DSMAEX
Des Moines
Wed 12/9
2:15 pm-9:38 pm
1 stop7h 23m
Alexandria
Wed 12/16
6:00 am-1:27 pm
1 stop7h 27m
$298
Des MoinesMobile
DSM - MOB
DSMMOB
Des Moines
Sun 11/1
5:40 am-11:17 am
1 stop5h 37m
Mobile
Sat 11/7
6:00 am-10:42 am
1 stop4h 42m
$309
Quickest round-trip
Des MoinesMobile
DSM - MOB
DSMMOB
Des Moines
Tue 8/25
11:28 am-3:50 pm
1 stop4h 22m
Mobile
Tue 9/1
5:00 pm-10:37 pm
1 stop5h 37m
$309
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mississippi
Have a flexible travel schedule? Discover the best time to fly to Mississippi from Des Moines with our price prediction graph.
DSM-MEM
DSM-AEX
DSM-MOB
DSM-BTR
DSM-GPT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mississippi
DSM-USMS
DSM-MEM
DSM-AEX
DSM-MOB
DSM-BTR
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Mississippi
Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated July 16, 2026.
Peruse reviews from past customers who have flown with American Airlines from Des Moines to Mississippi to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.2
Crew
7.9
Entertainment
6.8
Food
6.4
Boarding
7.5
Overall
7.1
Reviews
1 / 20
6.0
GoodKristin,Jul 2026
DCA - PHX
Comfort
7.2
Crew
7.9
Entertainment
6.8
Food
6.4
Boarding
7.5
Overall
7.1
Reviews
1 / 20
6.0
GoodKristin,Jul 2026
DCA - PHX
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Popular flights
Top destinations
Alternative routes for Des Moines to Mississippi
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Mississippi by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to Mississippi by cabin class
Find flights from Des Moines to Mississippi, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Mississippi flights
Browse other Des Moines and Mississippi flight options. Last updated on July 16, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Des Moines to Mississippi flights
Consider these flights traveling from Des Moines to Mississippi.
Top airline flying from Des Moines to Mississippi
Discover the top airline that operate flights from Des Moines to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$481 | FlexibilityNo cancel fee | On-time71% |