$137+ Cheap flights from Des Moines (DSM) to Mississippi
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/14. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JAN
Jul 18 — Jul 251
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to MississippiExplore the most affordable flight options available from Des Moines to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 18, 2026.
Explore the most affordable flight options available from Des Moines to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 18, 2026.
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:55 pm
DSM
- MEM
1 stop4h 11m
United Airlines
Mon 10/126:25 pm
MEM
- DSM
1 stop5h 10m
United Airlines
Deal found 6/13![United Airlines logo]()
$289
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/282:15 pm
DSM
- AEX
1 stop7h 23m
Delta
Sun 11/111:27 am
AEX
- DSM
1 stop6h 15m
Delta
Deal found 6/15![Delta logo]()
$298
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:45 am
DSM
- MOB
1 stop5h 48m
Delta
Mon 11/212:10 pm
MOB
- DSM
1 stop5h 32m
Delta
Deal found 6/16![Delta logo]()
$309
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:41 am
DSM
- BTR
1 stop7h 06m
Delta
Wed 8/56:07 am
BTR
- DSM
1 stop4h 36m
Delta
Deal found 6/15![Delta logo]()
$309
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/125:12 am
DSM
- GPT
1 stop5h 43m
American Airlines
Sat 7/186:35 pm
GPT
- DSM
1 stop5h 34m
American Airlines
Deal found 6/17![American Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:33 pm
DSM
- MEM
1 stop5h 45m
American Airlines
Sat 7/2512:03 pm
MEM
- DSM
1 stop6h 30m
American Airlines
Deal found 6/14![American Airlines logo]()
$310
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:15 am
DSM
- MEM
1 stop7h 15m
Southwest
Fri 8/282:55 pm
MEM
- DSM
2 stops7h 15m
Southwest
Deal found 6/17![Southwest logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/13:20 pm
DSM
- MEM
1 stop28h 30m
Multiple Airlines
Sat 8/89:04 am
MEM
- DSM
2 stops36h 27m
Multiple Airlines
Deal found 6/17![Multiple Airlines logo]()
$316
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/16:18 pm
DSM
- MEM
1 stop6h 00m
American Airlines
Sat 8/86:32 am
MEM
- DSM
1 stop6h 53m
American Airlines
Deal found 6/17![American Airlines logo]()
$318
This Southwest deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:50 am
DSM
- MEM
1 stop6h 55m
Southwest
Mon 11/212:20 pm
MEM
- DSM
2 stops9h 40m
Southwest
Deal found 6/18![Southwest logo]()
$323
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/94:48 pm
DSM
- BTR
1 stop6h 09m
American Airlines
Sun 7/126:16 pm
BTR
- DSM
1 stop5h 42m
American Airlines
Deal found 6/17![American Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/304:48 pm
DSM
- GPT
1 stop6h 13m
American Airlines
Sat 7/47:04 am
GPT
- DSM
1 stop7h 13m
American Airlines
Deal found 6/13![American Airlines logo]()
$324
Best flights from Des Moines to MississippiDiscover carefully curated flight deals from Des Moines to Mississippi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 18, 2026.
Discover carefully curated flight deals from Des Moines to Mississippi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 18, 2026.
This United Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/86:55 pm
DSM
- MEM
1 stop4h 11m
United Airlines
Mon 10/126:25 pm
MEM
- DSM
1 stop5h 10m
United Airlines
Deal found 6/13![United Airlines logo]()
$289
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:41 am
DSM
- BTR
1 stop7h 06m
Delta
Wed 8/56:07 am
BTR
- DSM
1 stop4h 36m
Delta
Deal found 6/15![Delta logo]()
$309
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/125:12 am
DSM
- GPT
1 stop5h 43m
American Airlines
Sat 7/186:35 pm
GPT
- DSM
1 stop5h 34m
American Airlines
Deal found 6/17![American Airlines logo]()
$309
This Southwest deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/252:40 pm
DSM
- MEM
2 stops7h 05m
Southwest
Fri 8/2812:20 pm
MEM
- DSM
2 stops9h 50m
Southwest
Deal found 6/17![Southwest logo]()
$320
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2811:04 am
DSM
- MOB
1 stop7h 13m
Delta
Mon 11/212:10 pm
MOB
- DSM
1 stop5h 32m
Delta
Deal found 6/16![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/203:15 pm
DSM
- MEM
1 stop6h 38m
United Airlines
Mon 11/236:22 pm
MEM
- DSM
1 stop6h 18m
United Airlines
Deal found 6/14![United Airlines logo]()
$318
This Delta deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:45 am
DSM
- MOB
1 stop5h 48m
Delta
Tue 11/176:00 am
MOB
- DSM
1 stop4h 18m
Delta
Deal found 6/17![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:20 am
DSM
- MEM
2 stops10h 15m
Southwest
Sat 7/259:45 am
MEM
- DSM
1 stop5h 05m
Southwest
Deal found 6/14![Southwest logo]()
$350
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/34:48 pm
DSM
- BTR
1 stop6h 09m
American Airlines
Sat 8/16:47 pm
BTR
- DSM
1 stop5h 11m
American Airlines
Deal found 6/16![American Airlines logo]()
$357
This Delta deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/255:40 am
DSM
- MEM
1 stop4h 59m
Delta
Fri 8/2811:46 am
MEM
- DSM
1 stop6h 04m
Delta
Deal found 6/17![Delta logo]()
$310
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/188:00 am
DSM
- MEM
1 stop6h 46m
United Airlines
Wed 8/197:15 am
MEM
- DSM
1 stop7h 01m
United Airlines
Deal found 6/14![United Airlines logo]()
$343
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/314:40 pm
DSM
- MEM
2 stops7h 15m
Southwest
Fri 8/73:20 pm
MEM
- DSM
1 stop6h 50m
Southwest
Deal found 6/16![Southwest logo]()
$352
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/275:30 am
DSM
- AEX
1 stop4h 43m
American Airlines
Tue 6/3010:44 am
AEX
- DSM
1 stop5h 19m
American Airlines
Deal found 6/16![American Airlines logo]()
$358
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/19:13 am
DSM
- MEM
1 stop5h 37m
United Airlines
Wed 9/27:15 am
MEM
- DSM
1 stop7h 01m
United Airlines
Deal found 6/15![United Airlines logo]()
$343
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:40 am
DSM
- MEM
1 stop7h 00m
Southwest
Mon 11/232:20 pm
MEM
- DSM
2 stops8h 40m
Southwest
Deal found 6/14![Southwest logo]()
$352
This Southwest deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/84:30 pm
DSM
- MEM
1 stop6h 55m
Southwest
Mon 10/124:50 pm
MEM
- DSM
2 stops6h 40m
Southwest
Deal found 6/13![Southwest logo]()
$352
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/17:02 pm
DSM
- AEX
1 stop4h 30m
American Airlines
Sun 7/55:41 pm
AEX
- DSM
1 stop6h 17m
American Airlines
Deal found 6/16![American Airlines logo]()
$388
This United Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:00 am
DSM
- AEX
2 stops9h 25m
United Airlines
Sun 7/54:00 pm
AEX
- DSM
1 stop6h 35m
United Airlines
Deal found 6/16![United Airlines logo]()
$364
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/25:00 pm
DSM
- BTR
1 stop4h 55m
Delta
Sun 7/54:00 pm
BTR
- DSM
1 stop6h 31m
Delta
Deal found 6/15![Delta logo]()
$399
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/24:48 pm
DSM
- BTR
1 stop6h 09m
American Airlines
Sun 7/56:16 pm
BTR
- DSM
1 stop5h 42m
American Airlines
Deal found 6/13![American Airlines logo]()
$403
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:15 am
DSM
- BTR
1 stop4h 58m
United Airlines
Sat 8/297:15 am
BTR
- DSM
1 stop6h 59m
United Airlines
Deal found 6/14![United Airlines logo]()
$389
This Southwest deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/47:00 am
DSM
- JAN
2 stops13h 10m
Southwest
Sun 9/67:30 am
JAN
- DSM
2 stops10h 45m
Southwest
Deal found 6/15![Southwest logo]()
$403
This American Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:30 am
DSM
- GPT
2 stops11h 37m
American Airlines
Tue 8/116:34 pm
GPT
- DSM
1 stop4h 51m
American Airlines
Deal found 6/15![American Airlines logo]()
$418
This Delta deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/156:00 am
DSM
- GPT
2 stops7h 05m
Delta
Wed 7/225:57 pm
GPT
- DSM
1 stop4h 32m
Delta
Deal found 6/17![Delta logo]()
$422
This United Airlines deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:00 am
DSM
- MOB
2 stops9h 06m
United Airlines
Tue 11/173:10 pm
MOB
- DSM
1 stop7h 20m
United Airlines
Deal found 6/15![United Airlines logo]()
$394
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/301:51 pm
DSM
- GPT
2 stops10h 08m
American Airlines
Sat 7/47:04 am
GPT
- DSM
1 stop7h 13m
American Airlines
Deal found 6/13![American Airlines logo]()
$418
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:55 am
DSM
- MOB
2 stops12h 02m
Delta
Thu 11/56:00 am
MOB
- DSM
1 stop4h 18m
Delta
Deal found 6/16![Delta logo]()
$432
This United Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:00 am
DSM
- MOB
2 stops8h 09m
United Airlines
Tue 11/33:10 pm
MOB
- DSM
2 stops9h 30m
United Airlines
Deal found 6/16![United Airlines logo]()
$399
This United Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:00 am
DSM
- AEX
2 stops7h 30m
United Airlines
Sat 9/59:45 am
AEX
- DSM
1 stop4h 29m
United Airlines
Deal found 6/16![United Airlines logo]()
$399
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:37 pm
DSM
- JAN
1 stop6h 22m
American Airlines
Sun 7/57:26 pm
JAN
- DSM
1 stop4h 32m
American Airlines
Deal found 6/16![American Airlines logo]()
$467
Last-minute flights from Des Moines to MississippiDiscover last-minute flight deals from Des Moines to Mississippi. Data last updated June 18, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mississippi. Data last updated June 18, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/304:48 pm
DSM
- GPT
1 stop6h 13m
American Airlines
Sat 7/47:04 am
GPT
- DSM
1 stop7h 13m
American Airlines
Deal found 6/13![American Airlines logo]()
$324
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/25:00 pm
DSM
- BTR
1 stop4h 55m
Delta
Sun 7/54:00 pm
BTR
- DSM
1 stop6h 31m
Delta
Deal found 6/16![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/34:48 pm
DSM
- BTR
1 stop6h 09m
American Airlines
Sat 8/16:47 pm
BTR
- DSM
1 stop5h 11m
American Airlines
Deal found 6/16![American Airlines logo]()
$357
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/49:41 am
DSM
- MEM
1 stop7h 01m
American Airlines
Fri 7/1012:03 pm
MEM
- DSM
1 stop6h 30m
American Airlines
Deal found 6/16![American Airlines logo]()
$337
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:10 am
DSM
- MEM
2 stops8h 00m
Southwest
Fri 7/105:10 pm
MEM
- DSM
1 stop5h 15m
Southwest
Deal found 6/16![Southwest logo]()
$342
This Delta deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:41 am
DSM
- BTR
1 stop7h 06m
Delta
Wed 8/56:07 am
BTR
- DSM
1 stop4h 36m
Delta
Deal found 6/15![Delta logo]()
$309
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/94:48 pm
DSM
- BTR
1 stop6h 09m
American Airlines
Sun 7/126:16 pm
BTR
- DSM
1 stop5h 42m
American Airlines
Deal found 6/17![American Airlines logo]()
$324
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/125:12 am
DSM
- GPT
1 stop5h 43m
American Airlines
Sat 7/186:35 pm
GPT
- DSM
1 stop5h 34m
American Airlines
Deal found 6/17![American Airlines logo]()
$309
This Delta deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:37 pm
DSM
- MOB
1 stop4h 48m
Delta
Tue 7/214:26 pm
MOB
- DSM
1 stop6h 03m
Delta
Deal found 6/17![Delta logo]()
$309
This American Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/146:33 pm
DSM
- MEM
1 stop5h 45m
American Airlines
Sat 7/2512:03 pm
MEM
- DSM
1 stop6h 30m
American Airlines
Deal found 6/14![American Airlines logo]()
$310
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:20 am
DSM
- MEM
2 stops10h 15m
Southwest
Sat 7/259:45 am
MEM
- DSM
1 stop5h 05m
Southwest
Deal found 6/14![Southwest logo]()
$350
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/314:40 pm
DSM
- MEM
2 stops7h 15m
Southwest
Fri 8/73:20 pm
MEM
- DSM
1 stop6h 50m
Southwest
Deal found 6/16![Southwest logo]()
$352
One-way flights from Des Moines to MississippiSearch for one-way flight options from Des Moines to Mississippi. Find affordable one-way fares based on user searches. Data last updated June 18, 2026.
Search for one-way flight options from Des Moines to Mississippi. Find affordable one-way fares based on user searches. Data last updated June 18, 2026.
This Delta deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/142:25 pm
DSM
- MEM
1 stop6h 10m
Delta
Deal found 6/14![Delta logo]()
$137
This American Airlines deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/206:33 pm
DSM
- MEM
1 stop5h 45m
American Airlines
Deal found 6/16![American Airlines logo]()
$174
This Southwest deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/145:20 am
DSM
- MEM
2 stops10h 15m
Southwest
Deal found 6/14![Southwest logo]()
$177
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/204:40 pm
DSM
- MEM
2 stops7h 15m
Southwest
Deal found 6/16![Southwest logo]()
$179
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:37 pm
DSM
- JAN
1 stop4h 32m
Delta
Deal found 6/16![Delta logo]()
$202
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:10 am
DSM
- JAN
2 stops15h 50m
Southwest
Deal found 6/16![Southwest logo]()
$205
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/66:03 pm
DSM
- MEM
1 stop4h 18m
Delta
Deal found 6/16![Delta logo]()
$230
This Southwest deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/64:40 pm
DSM
- MEM
2 stops7h 15m
Southwest
Deal found 6/16![Southwest logo]()
$235
This American Airlines deal was found by Cheapflights users on 6/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/104:13 pm
DSM
- BTR
1 stop6h 42m
American Airlines
Deal found 6/17![American Airlines logo]()
$238
This Delta deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/15:41 am
DSM
- BTR
1 stop7h 06m
Delta
Deal found 6/16![Delta logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/205:30 pm
DSM
- MEM
3 stops49h 33m
Multiple Airlines
Deal found 6/16![Multiple Airlines logo]()
$283
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/291:37 pm
DSM
- BTR
1 stop8h 05m
American Airlines
Deal found 6/13![American Airlines logo]()
$304
Find flight deals from Des Moines to Mississippi
Keep the following information in mind while searching for Des Moines to Mississippi flight deals. Data was last updated June 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $289 (United Airlines) |
One-way from | $137 (Delta) |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 18, 2026.
Use the filters below to find and compare flights from Des Moines to Mississippi that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Des MoinesMemphis
DSM - MEM
DSMMEM
Des Moines
Thu 10/8
6:55 pm-11:06 pm
1 stop4h 11m
Memphis
Mon 10/12
6:25 pm-11:35 pm
1 stop5h 10m
$289
Des MoinesBaton Rouge
DSM - BTR
DSMBTR
Des Moines
Thu 7/9
5:41 am-12:47 pm
1 stop7h 06m
Baton Rouge Ryan
Wed 8/5
6:07 am-10:43 am
1 stop4h 36m
$309
Des MoinesGulfport
DSM - GPT
DSMGPT
Des Moines
Sun 7/12
5:12 am-10:55 am
1 stop5h 43m
Gulfport Biloxi Regional
Sat 7/18
6:35 pm-12:09 am
1 stop5h 34m
$309
Des MoinesMobile
DSM - MOB
DSMMOB
Des Moines
Wed 10/28
11:04 am-6:17 pm
1 stop7h 13m
Mobile
Mon 11/2
12:10 pm-5:42 pm
1 stop5h 32m
$309
Des MoinesMobile
DSM - MOB
DSMMOB
Des Moines
Tue 11/10
5:45 am-11:33 am
1 stop5h 48m
Mobile
Tue 11/17
6:00 am-10:18 am
1 stop4h 18m
$309
Des MoinesMemphis
DSM - MEM
DSMMEM
Des Moines
Tue 8/25
5:40 am-10:39 am
1 stop4h 59m
Memphis
Fri 8/28
11:46 am-5:50 pm
1 stop6h 04m
$310
Des MoinesMemphis
DSM - MEM
DSMMEM
Des Moines
Fri 11/20
3:15 pm-9:53 pm
1 stop6h 38m
Memphis
Mon 11/23
6:22 pm-12:40 am
1 stop6h 18m
$318
Des MoinesMemphis
DSM - MEM
DSMMEM
Des Moines
Tue 8/25
2:40 pm-9:45 pm
2 stops7h 05m
Memphis
Fri 8/28
12:20 pm-10:10 pm
2 stops9h 50m
$320
Des MoinesMemphis
DSM - MEM
DSMMEM
Des Moines
Tue 8/18
8:00 am-2:46 pm
1 stop6h 46m
Memphis
Wed 8/19
7:15 am-2:16 pm
1 stop7h 01m
$343
Des MoinesMemphis
DSM - MEM
DSMMEM
Des Moines
Tue 9/1
9:13 am-2:50 pm
1 stop5h 37m
Memphis
Wed 9/2
7:15 am-2:16 pm
1 stop7h 01m
$343
Showing 1-10 of 46 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mississippi
Have a flexible travel schedule? Discover the best time to fly to Mississippi from Des Moines with our price prediction graph.
DSM-MEM
DSM-AEX
DSM-MOB
DSM-BTR
DSM-GPT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mississippi
DSM-USMS
DSM-MEM
DSM-AEX
DSM-MOB
DSM-BTR
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Mississippi
Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated June 18, 2026.
Peruse reviews from past customers who have flown with United Airlines and American Airlines from Des Moines to Mississippi to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
6.6
Boarding
7.7
Overall
7.4
Crew
8.1
Entertainment
7.1
Comfort
7.3
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Food
6.6
Boarding
7.7
Overall
7.4
Crew
8.1
Entertainment
7.1
Comfort
7.3
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Food
6.6
Boarding
7.7
Overall
7.4
Crew
8.1
Entertainment
7.1
Comfort
7.3
Reviews
1 / 20
4.0
OkayDynasty,May 2026
LAX - EWR
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Mississippi
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Complete your trip
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Des Moines and Mississippi flights
Browse other Des Moines and Mississippi flight options. Last updated on June 18, 2026.
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Des Moines to Mississippi flights
Consider these flights traveling from Des Moines to Mississippi.
Top 2 airlines flying from Des Moines to Mississippi
Discover the top 2 airlines that operate flights from Des Moines to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$481 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$318 | Average$381 | FlexibilityNo cancel fee | On-time69% |