$172+ Cheap flights from Des Moines (DSM) to Mississippi
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/14. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JAN
Jun 5 — Jun 121
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to MississippiExplore the most affordable flight options available from Des Moines to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 6, 2026.
Explore the most affordable flight options available from Des Moines to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 6, 2026.
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:50 am
DSM
- MEM
1 stop4h 35m
Delta
Tue 6/235:15 am
MEM
- DSM
1 stop5h 28m
Delta
Deal found 5/4![Delta logo]()
$271
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/165:20 am
DSM
- MEM
2 stops9h 40m
Southwest
Tue 6/235:20 am
MEM
- DSM
1 stop6h 10m
Southwest
Deal found 5/4![Southwest logo]()
$276
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:00 am
DSM
- MEM
1 stop6h 04m
United Airlines
Tue 10/66:22 pm
MEM
- DSM
1 stop4h 39m
United Airlines
Deal found 5/5![United Airlines logo]()
$283
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/105:45 am
DSM
- MOB
1 stop5h 48m
Delta
Tue 11/1712:10 pm
MOB
- DSM
1 stop5h 32m
Delta
Deal found 5/1![Delta logo]()
$309
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:33 pm
DSM
- BTR
1 stop7h 27m
Delta
Tue 6/23:48 pm
BTR
- DSM
1 stop6h 44m
Delta
Deal found 5/3![Delta logo]()
$309
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:28 pm
DSM
- MEM
1 stop4h 52m
Delta
Fri 5/295:30 am
MEM
- DSM
1 stop5h 38m
Delta
Deal found 5/4![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:15 am
DSM
- GPT
1 stop5h 06m
United Airlines
Sat 10/175:04 pm
GPT
- DSM
1 stop5h 19m
United Airlines
Deal found 5/3![United Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:04 am
DSM
- MOB
2 stops10h 52m
American Airlines
Tue 11/175:20 am
MOB
- DSM
1 stop8h 11m
American Airlines
Deal found 5/5![American Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:00 am
DSM
- BTR
2 stops8h 48m
American Airlines
Tue 6/26:28 pm
BTR
- DSM
1 stop5h 49m
American Airlines
Deal found 5/3![American Airlines logo]()
$314
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:09 pm
DSM
- MEM
1 stop4h 55m
American Airlines
Fri 5/295:00 am
MEM
- DSM
2 stops8h 18m
American Airlines
Deal found 5/4![American Airlines logo]()
$314
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:20 am
DSM
- MEM
2 stops9h 40m
Southwest
Wed 6/245:20 am
MEM
- DSM
2 stops9h 45m
Southwest
Deal found 5/3![Southwest logo]()
$315
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/259:14 am
DSM
- MEM
1 stop5h 15m
United Airlines
Fri 5/293:23 pm
MEM
- DSM
1 stop7h 12m
United Airlines
Deal found 5/4![United Airlines logo]()
$316
Best flights from Des Moines to MississippiDiscover carefully curated flight deals from Des Moines to Mississippi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 6, 2026.
Discover carefully curated flight deals from Des Moines to Mississippi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 6, 2026.
This Delta deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/162:25 pm
DSM
- MEM
1 stop5h 04m
Delta
Tue 6/236:20 am
MEM
- DSM
1 stop4h 23m
Delta
Deal found 5/2![Delta logo]()
$271
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:20 am
DSM
- MEM
2 stops9h 40m
Southwest
Wed 6/245:20 am
MEM
- DSM
1 stop6h 10m
Southwest
Deal found 5/3![Southwest logo]()
$276
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/271:37 pm
DSM
- BTR
1 stop8h 11m
American Airlines
Tue 6/306:28 pm
BTR
- DSM
1 stop5h 44m
American Airlines
Deal found 5/4![American Airlines logo]()
$309
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:20 am
DSM
- BTR
1 stop5h 00m
United Airlines
Mon 8/36:09 pm
BTR
- DSM
1 stop4h 26m
United Airlines
Deal found 5/3![United Airlines logo]()
$309
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/165:20 am
DSM
- MEM
2 stops9h 40m
Southwest
Tue 6/2312:25 pm
MEM
- DSM
2 stops10h 20m
Southwest
Deal found 5/4![Southwest logo]()
$287
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:33 pm
DSM
- BTR
1 stop7h 27m
Delta
Tue 6/23:48 pm
BTR
- DSM
1 stop6h 44m
Delta
Deal found 5/3![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:15 am
DSM
- GPT
1 stop5h 06m
United Airlines
Sat 10/175:04 pm
GPT
- DSM
1 stop5h 19m
United Airlines
Deal found 5/3![United Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:00 am
DSM
- BTR
2 stops8h 48m
American Airlines
Tue 6/26:28 pm
BTR
- DSM
1 stop5h 49m
American Airlines
Deal found 5/3![American Airlines logo]()
$314
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/245:27 am
DSM
- MEM
1 stop4h 52m
Delta
Thu 5/286:00 am
MEM
- DSM
1 stop4h 16m
Delta
Deal found 5/4![Delta logo]()
$316
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/247:05 am
DSM
- MEM
2 stops8h 00m
Southwest
Thu 5/285:05 am
MEM
- DSM
1 stop6h 40m
Southwest
Deal found 5/4![Southwest logo]()
$321
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:12 am
DSM
- BTR
1 stop5h 31m
American Airlines
Mon 8/36:28 pm
BTR
- DSM
1 stop5h 41m
American Airlines
Deal found 5/3![American Airlines logo]()
$324
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/183:00 pm
DSM
- MEM
1 stop4h 50m
United Airlines
Wed 8/195:45 am
MEM
- DSM
1 stop4h 26m
United Airlines
Deal found 5/2![United Airlines logo]()
$341
This Southwest deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:40 am
DSM
- MEM
2 stops7h 50m
Southwest
Tue 10/69:45 am
MEM
- DSM
2 stops12h 05m
Southwest
Deal found 5/5![Southwest logo]()
$324
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/147:06 am
DSM
- GPT
2 stops10h 22m
American Airlines
Sat 10/1711:18 am
GPT
- DSM
1 stop7h 38m
American Airlines
Deal found 5/3![American Airlines logo]()
$329
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/136:15 am
DSM
- GPT
1 stop5h 06m
United Airlines
Sat 10/175:04 pm
GPT
- DSM
1 stop5h 19m
United Airlines
Deal found 5/3![United Airlines logo]()
$346
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/26:03 pm
DSM
- MEM
1 stop4h 18m
Delta
Wed 7/84:21 pm
MEM
- DSM
1 stop6h 08m
Delta
Deal found 5/1![Delta logo]()
$347
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/312:05 pm
DSM
- MEM
1 stop7h 30m
Southwest
Wed 7/85:20 am
MEM
- DSM
1 stop6h 10m
Southwest
Deal found 5/1![Southwest logo]()
$347
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/16:50 pm
DSM
- MEM
1 stop4h 31m
United Airlines
Tue 6/28:45 am
MEM
- DSM
1 stop7h 30m
United Airlines
Deal found 5/1![United Airlines logo]()
$348
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/125:45 am
DSM
- MOB
1 stop5h 48m
Delta
Mon 10/196:00 am
MOB
- DSM
1 stop4h 18m
Delta
Deal found 5/4![Delta logo]()
$354
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:30 pm
DSM
- MOB
1 stop4h 27m
Delta
Sun 10/186:00 am
MOB
- DSM
1 stop4h 18m
Delta
Deal found 5/4![Delta logo]()
$354
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:00 am
DSM
- JAN
2 stops10h 49m
American Airlines
Mon 9/145:22 pm
JAN
- DSM
1 stop5h 45m
American Airlines
Deal found 5/2![American Airlines logo]()
$392
This Southwest deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:30 am
DSM
- JAN
2 stops8h 25m
Southwest
Wed 8/121:30 pm
JAN
- DSM
2 stops8h 25m
Southwest
Deal found 5/5![Southwest logo]()
$372
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:40 am
DSM
- JAN
1 stop6h 19m
Delta
Wed 8/121:00 pm
JAN
- DSM
1 stop4h 48m
Delta
Deal found 5/5![Delta logo]()
$362
This United Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/183:00 pm
DSM
- JAN
1 stop6h 18m
United Airlines
Wed 8/197:00 am
JAN
- DSM
2 stops9h 13m
United Airlines
Deal found 5/2![United Airlines logo]()
$402
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1911:11 am
DSM
- BTR
2 stops9h 34m
American Airlines
Sat 5/232:18 pm
BTR
- DSM
2 stops9h 54m
American Airlines
Deal found 5/4![American Airlines logo]()
$425
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:20 am
DSM
- JAN
1 stop7h 12m
United Airlines
Sat 5/309:20 am
JAN
- DSM
1 stop5h 00m
United Airlines
Deal found 5/1![United Airlines logo]()
$412
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:40 am
DSM
- JAN
2 stops12h 20m
Southwest
Sun 9/206:15 am
JAN
- DSM
2 stops12h 15m
Southwest
Deal found 5/3![Southwest logo]()
$423
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/201:25 pm
DSM
- JAN
1 stop8h 33m
American Airlines
Sun 5/246:27 am
JAN
- DSM
1 stop9h 24m
American Airlines
Deal found 5/5![American Airlines logo]()
$427
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/22:33 pm
DSM
- GPT
1 stop7h 18m
Delta
Thu 6/46:32 am
GPT
- DSM
1 stop4h 36m
Delta
Deal found 4/30![Delta logo]()
$406
This United Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:00 am
DSM
- GPT
2 stops10h 02m
United Airlines
Wed 9/22:00 pm
GPT
- DSM
2 stops9h 55m
United Airlines
Deal found 5/1![United Airlines logo]()
$444
Last-minute flights from Des Moines to MississippiDiscover last-minute flight deals from Des Moines to Mississippi. Data last updated May 6, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mississippi. Data last updated May 6, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/247:05 am
DSM
- MEM
2 stops8h 00m
Southwest
Thu 5/285:05 am
MEM
- DSM
1 stop6h 40m
Southwest
Deal found 5/4![Southwest logo]()
$321
This United Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/259:14 am
DSM
- MEM
1 stop5h 15m
United Airlines
Fri 5/293:23 pm
MEM
- DSM
1 stop7h 12m
United Airlines
Deal found 5/4![United Airlines logo]()
$316
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/265:28 pm
DSM
- MEM
1 stop4h 52m
Delta
Fri 5/295:30 am
MEM
- DSM
1 stop5h 38m
Delta
Deal found 5/4![Delta logo]()
$309
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/267:09 pm
DSM
- MEM
1 stop4h 55m
American Airlines
Fri 5/295:00 am
MEM
- DSM
2 stops8h 18m
American Airlines
Deal found 5/4![American Airlines logo]()
$314
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/282:33 pm
DSM
- BTR
1 stop7h 27m
Delta
Tue 6/23:48 pm
BTR
- DSM
1 stop6h 44m
Delta
Deal found 5/3![Delta logo]()
$309
This American Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/285:00 am
DSM
- BTR
2 stops8h 48m
American Airlines
Tue 6/26:28 pm
BTR
- DSM
1 stop5h 49m
American Airlines
Deal found 5/3![American Airlines logo]()
$314
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/25:27 am
DSM
- MOB
1 stop6h 38m
Delta
Sun 6/76:05 am
MOB
- DSM
1 stop4h 38m
Delta
Deal found 4/30![Delta logo]()
$309
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:09 pm
DSM
- MOB
1 stop4h 46m
American Airlines
Tue 6/912:42 pm
MOB
- DSM
2 stops11h 08m
American Airlines
Deal found 5/5![American Airlines logo]()
$314
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:50 am
DSM
- MEM
1 stop4h 35m
Delta
Tue 6/235:15 am
MEM
- DSM
1 stop5h 28m
Delta
Deal found 5/4![Delta logo]()
$271
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/165:20 am
DSM
- MEM
2 stops9h 40m
Southwest
Tue 6/235:20 am
MEM
- DSM
1 stop6h 10m
Southwest
Deal found 5/4![Southwest logo]()
$276
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:20 am
DSM
- MEM
2 stops9h 40m
Southwest
Wed 6/245:20 am
MEM
- DSM
2 stops9h 45m
Southwest
Deal found 5/3![Southwest logo]()
$315
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/271:47 pm
DSM
- BTR
2 stops9h 12m
American Airlines
Tue 6/306:16 pm
BTR
- DSM
1 stop5h 42m
American Airlines
Deal found 5/4![American Airlines logo]()
$329
One-way flights from Des Moines to MississippiSearch for one-way flight options from Des Moines to Mississippi. Find affordable one-way fares based on user searches. Data last updated May 6, 2026.
Search for one-way flight options from Des Moines to Mississippi. Find affordable one-way fares based on user searches. Data last updated May 6, 2026.
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/147:45 am
DSM
- MEM
1 stop10h 10m
Allegiant Air
Deal found 5/4![Allegiant Air logo]()
$172
This Delta deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/186:50 am
DSM
- MEM
1 stop4h 35m
Delta
Deal found 5/3![Delta logo]()
$174
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/304:48 pm
DSM
- JAN
1 stop5h 32m
American Airlines
Deal found 5/1![American Airlines logo]()
$174
This Southwest deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/305:35 am
DSM
- JAN
2 stops12h 00m
Southwest
Deal found 5/4![Southwest logo]()
$185
This Southwest deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/184:40 pm
DSM
- MEM
2 stops7h 15m
Southwest
Deal found 5/3![Southwest logo]()
$189
This Delta deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/155:35 am
DSM
- BTR
1 stop7h 12m
Delta
Deal found 5/1![Delta logo]()
$264
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/25:23 am
DSM
- MOB
1 stop5h 53m
American Airlines
Deal found 5/5![American Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:45 am
DSM
- MEM
1 stop10h 10m
Allegiant Air
Deal found 5/4![Allegiant Air logo]()
$291
This Southwest deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:25 am
DSM
- JAN
2 stops13h 40m
Southwest
Deal found 5/1![Southwest logo]()
$296
This Delta deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:27 am
DSM
- MEM
1 stop6h 12m
Delta
Deal found 5/4![Delta logo]()
$304
This United Airlines deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1111:40 am
DSM
- MEM
2 stops10h 14m
United Airlines
Deal found 5/3![United Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/185:01 pm
DSM
- MEM
1 stop6h 58m
American Airlines
Deal found 5/2![American Airlines logo]()
$330
Find flight deals from Des Moines to Mississippi
Keep the following information in mind while searching for Des Moines to Mississippi flight deals. Data was last updated May 6, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $271 (Delta) |
One-way from | $172 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 6, 2026.
Use the filters below to find and compare flights from Des Moines to Mississippi that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesMemphis
DSM - MEM
DSMMEM
Des Moines
Tue 6/16
2:25 pm-7:29 pm
1 stop5h 04m
Memphis
Tue 6/23
6:20 am-10:43 am
1 stop4h 23m
$271
Des MoinesMemphis
DSM - MEM
DSMMEM
Des Moines
Wed 6/17
5:20 am-3:00 pm
2 stops9h 40m
Memphis
Wed 6/24
5:20 am-11:30 am
1 stop6h 10m
$276
Des MoinesMemphis
DSM - MEM
DSMMEM
Des Moines
Tue 6/16
5:20 am-3:00 pm
2 stops9h 40m
Memphis
Tue 6/23
12:25 pm-10:45 pm
2 stops10h 20m
$287
Des MoinesBaton Rouge
DSM - BTR
DSMBTR
Des Moines
Sat 6/27
1:37 pm-9:48 pm
1 stop8h 11m
Baton Rouge Ryan
Tue 6/30
6:28 pm-12:12 am
1 stop5h 44m
$309
Des MoinesBaton Rouge
DSM - BTR
DSMBTR
Des Moines
Tue 7/7
6:20 am-11:20 am
1 stop5h 00m
Baton Rouge Ryan
Mon 8/3
6:09 pm-10:35 pm
1 stop4h 26m
$309
Des MoinesBaton Rouge
DSM - BTR
DSMBTR
Des Moines
Thu 5/28
2:33 pm-10:00 pm
1 stop7h 27m
Baton Rouge Ryan
Tue 6/2
3:48 pm-10:32 pm
1 stop6h 44m
$309
Des MoinesGulfport
DSM - GPT
DSMGPT
Des Moines
Wed 10/14
6:15 am-11:21 am
1 stop5h 06m
Gulfport Biloxi Regional
Sat 10/17
5:04 pm-10:23 pm
1 stop5h 19m
$309
Des MoinesBaton Rouge
DSM - BTR
DSMBTR
Des Moines
Thu 5/28
5:00 am-1:48 pm
2 stops8h 48m
Baton Rouge Ryan
Tue 6/2
6:28 pm-12:17 am
1 stop5h 49m
$314
Des MoinesMemphis
DSM - MEM
DSMMEM
Des Moines
Sun 5/24
5:27 am-10:19 am
1 stop4h 52m
Memphis
Thu 5/28
6:00 am-10:16 am
1 stop4h 16m
$316
Des MoinesMemphis
DSM - MEM
DSMMEM
Des Moines
Sun 5/24
7:05 am-3:05 pm
2 stops8h 00m
Memphis
Thu 5/28
5:05 am-11:45 am
1 stop6h 40m
$321
Showing 1-10 of 50 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mississippi
Have a flexible travel schedule? Discover the best time to fly to Mississippi from Des Moines with our price prediction graph.
DSM-MEM
DSM-MOB
DSM-BTR
DSM-GPT
DSM-JAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mississippi
DSM-USMS
DSM-MEM
DSM-MOB
DSM-BTR
DSM-GPT
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Mississippi
Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated May 6, 2026.
Peruse reviews from past customers who have flown with United Airlines and American Airlines from Des Moines to Mississippi to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
6.6
Comfort
7.3
Crew
8.1
Overall
7.4
Boarding
7.7
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAnonymous,Apr 2026
DFW - EWR
Food
6.6
Comfort
7.3
Crew
8.1
Overall
7.4
Boarding
7.7
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAnonymous,Apr 2026
DFW - EWR
Food
6.6
Comfort
7.3
Crew
8.1
Overall
7.4
Boarding
7.7
Entertainment
7.1
Reviews
1 / 20
8.0
ExcellentAnonymous,Apr 2026
DFW - EWR
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Mississippi
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Complete your trip
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Des Moines and Mississippi flights
Browse other Des Moines and Mississippi flight options. Last updated on May 6, 2026.
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Des Moines to Mississippi flights
Consider these flights traveling from Des Moines to Mississippi.
Top 2 airlines flying from Des Moines to Mississippi
Discover the top 2 airlines that operate flights from Des Moines to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 6, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$531 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$318 | Average$381 | FlexibilityNo cancel fee | On-time69% |