$140+ Cheap flights from Des Moines (DSM) to Mississippi
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — JAN
Sep 16 — Sep 231
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Des Moines to MississippiExplore the most affordable flight options available from Des Moines to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 17, 2026.
Explore the most affordable flight options available from Des Moines to Mississippi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 17, 2026.
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/162:58 pm -
1 stop5h 36m
Thu 12/317:00 am -
1 stop5h 05m
Deal found 8/13![Delta logo]()
$233
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:32 am -
1 stop6h 10m
Mon 9/144:33 pm -
1 stop7h 00m
Deal found 8/15![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:15 am -
1 stop7h 15m
Wed 10/75:10 am -
2 stops9h 10m
Deal found 8/16![Southwest logo]()
$284
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:10 am -
1 stop7h 00m
Thu 10/84:10 pm -
1 stop6h 45m
Deal found 8/13![Southwest logo]()
$286
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:30 am -
1 stop4h 37m
Thu 10/85:56 pm -
1 stop5h 11m
Deal found 8/14![American Airlines logo]()
$304
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/264:14 pm -
1 stop6h 25m
Sat 10/35:15 pm -
1 stop5h 57m
Deal found 8/12![American Airlines logo]()
$308
This Delta deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:54 pm -
1 stop4h 27m
Mon 9/213:02 pm -
1 stop7h 24m
Deal found 8/15![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/24:30 pm -
1 stop7h 25m
Mon 10/52:35 pm -
2 stops8h 20m
Deal found 8/15![Southwest logo]()
$310
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/205:57 pm -
1 stop6h 26m
Wed 9/236:30 pm -
1 stop4h 42m
Deal found 8/15![American Airlines logo]()
$318
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:50 pm -
1 stop4h 58m
Tue 11/179:12 am -
1 stop5h 01m
Deal found 8/12![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:25 pm -
1 stop7h 10m
Mon 9/142:55 pm -
2 stops7h 20m
Deal found 8/15![Southwest logo]()
$319
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:22 pm -
1 stop5h 02m
Sat 9/266:22 pm -
1 stop4h 50m
Deal found 8/16![American Airlines logo]()
$319
Best flights from Des Moines to MississippiDiscover carefully curated flight deals from Des Moines to Mississippi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 17, 2026.
Discover carefully curated flight deals from Des Moines to Mississippi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 17, 2026.
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/47:29 am -
1 stop6h 18m
Mon 2/82:17 pm -
1 stop4h 52m
Deal found 8/17![American Airlines logo]()
$279
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3010:59 am -
1 stop7h 00m
Wed 10/73:35 pm -
1 stop6h 58m
Deal found 8/16![Delta logo]()
$279
This Southwest deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:15 am -
1 stop7h 15m
Wed 10/75:10 am -
2 stops9h 10m
Deal found 8/16![Southwest logo]()
$284
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:02 pm -
1 stop6h 54m
Sun 9/69:47 am -
1 stop4h 29m
Deal found 8/13![United Airlines logo]()
$327
This Delta deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/27:00 am -
1 stop4h 19m
Mon 10/57:18 am -
1 stop6h 31m
Deal found 8/15![Delta logo]()
$289
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/43:10 pm -
1 stop6h 50m
Mon 2/812:45 pm -
2 stops8h 35m
Deal found 8/14![Southwest logo]()
$304
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/264:14 pm -
1 stop6h 25m
Sat 10/35:15 pm -
1 stop5h 57m
Deal found 8/12![American Airlines logo]()
$308
This Delta deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:54 pm -
1 stop4h 27m
Mon 9/213:02 pm -
1 stop7h 24m
Deal found 8/15![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/293:02 pm -
1 stop6h 26m
Wed 9/29:35 am -
1 stop4h 39m
Deal found 8/14![United Airlines logo]()
$349
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:26 pm -
1 stop4h 33m
Sun 11/85:12 am -
1 stop5h 36m
Deal found 8/12![American Airlines logo]()
$326
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:40 am -
2 stops15h 20m
Sun 11/85:30 am -
2 stops7h 40m
Deal found 8/14![Southwest logo]()
$344
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:50 pm -
1 stop4h 58m
Tue 11/179:12 am -
1 stop5h 01m
Deal found 8/16![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/273:02 pm -
1 stop6h 26m
Mon 8/319:35 am -
2 stops10h 51m
Deal found 8/12![United Airlines logo]()
$354
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/411:09 am -
1 stop5h 55m
Sun 11/86:34 pm -
1 stop5h 23m
Deal found 8/12![American Airlines logo]()
$326
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/243:50 pm -
1 stop6h 40m
Sun 9/275:35 am -
1 stop6h 00m
Deal found 8/14![Southwest logo]()
$353
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/283:02 pm -
1 stop6h 57m
Tue 9/17:00 am -
2 stops9h 19m
Deal found 8/12![United Airlines logo]()
$354
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/222:46 pm -
2 stops7h 22m
Sat 9/264:00 pm -
1 stop6h 26m
Deal found 8/16![Delta logo]()
$324
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:22 pm -
1 stop4h 54m
Wed 9/96:22 pm -
1 stop4h 50m
Deal found 8/13![American Airlines logo]()
$334
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:39 am -
1 stop6h 10m
Sun 11/85:35 am -
1 stop5h 07m
Deal found 8/13![Delta logo]()
$326
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/58:00 am -
1 stop5h 23m
Sat 1/91:57 pm -
2 stops9h 42m
Deal found 8/13![United Airlines logo]()
$374
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:20 am -
2 stops11h 50m
Sun 9/206:15 am -
2 stops9h 00m
Deal found 8/14![Southwest logo]()
$383
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2811:28 am -
1 stop4h 22m
Sun 8/306:00 am -
1 stop4h 43m
Deal found 8/13![Delta logo]()
$349
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:00 am -
1 stop5h 18m
Mon 10/51:55 pm -
2 stops9h 53m
Deal found 8/14![United Airlines logo]()
$397
This Southwest deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/287:00 am -
2 stops11h 00m
Tue 9/11:30 pm -
2 stops8h 25m
Deal found 8/12![Southwest logo]()
$402
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/283:02 pm -
1 stop6h 57m
Sun 8/307:00 am -
2 stops10h 28m
Deal found 8/13![United Airlines logo]()
$397
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/191:09 pm -
2 stops9h 43m
Sun 9/204:33 pm -
1 stop6h 39m
Deal found 8/14![American Airlines logo]()
$468
This Southwest deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/145:40 am -
2 stops12h 20m
Mon 9/2112:40 pm -
2 stops9h 35m
Deal found 8/15![Southwest logo]()
$431
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2911:32 am -
2 stops8h 06m
Wed 9/27:08 am -
2 stops9h 11m
Deal found 8/13![United Airlines logo]()
$402
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:00 am -
2 stops9h 01m
Fri 10/23:48 pm -
1 stop6h 38m
Deal found 8/13![Delta logo]()
$422
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/103:01 pm -
1 stop6h 58m
Tue 11/176:55 am -
2 stops13h 41m
Deal found 8/13![United Airlines logo]()
$404
Last-minute flights from Des Moines to MississippiDiscover last-minute flight deals from Des Moines to Mississippi. Data last updated August 17, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Mississippi. Data last updated August 17, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:22 pm -
1 stop4h 54m
Wed 9/96:22 pm -
1 stop4h 50m
Deal found 8/13![American Airlines logo]()
$334
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:02 pm -
1 stop6h 54m
Sun 9/69:47 am -
1 stop4h 29m
Deal found 8/13![United Airlines logo]()
$327
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:32 am -
1 stop6h 10m
Mon 9/144:33 pm -
1 stop7h 00m
Deal found 8/15![United Airlines logo]()
$279
This Southwest deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:25 pm -
1 stop7h 10m
Mon 9/142:55 pm -
2 stops7h 20m
Deal found 8/15![Southwest logo]()
$319
This Delta deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:54 pm -
1 stop4h 27m
Mon 9/213:02 pm -
1 stop7h 24m
Deal found 8/15![Delta logo]()
$309
This Delta deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:54 pm -
1 stop4h 26m
Mon 9/214:37 pm -
1 stop5h 49m
Deal found 8/11![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/187:58 pm -
1 stop4h 25m
Sun 9/205:16 am -
1 stop5h 03m
Deal found 8/14![American Airlines logo]()
$328
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/205:57 pm -
1 stop6h 26m
Wed 9/236:30 pm -
1 stop4h 42m
Deal found 8/15![American Airlines logo]()
$318
This American Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:22 pm -
1 stop5h 02m
Sat 9/266:22 pm -
1 stop4h 50m
Deal found 8/16![American Airlines logo]()
$319
This Delta deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/222:46 pm -
2 stops7h 22m
Sat 9/264:00 pm -
1 stop6h 26m
Deal found 8/16![Delta logo]()
$324
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/264:14 pm -
1 stop6h 25m
Sat 10/35:15 pm -
1 stop5h 57m
Deal found 8/12![American Airlines logo]()
$308
This Southwest deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:15 am -
1 stop7h 15m
Wed 10/75:10 am -
2 stops9h 10m
Deal found 8/16![Southwest logo]()
$284
One-way flights from Des Moines to MississippiSearch for one-way flight options from Des Moines to Mississippi. Find affordable one-way fares based on user searches. Data last updated August 17, 2026.
Search for one-way flight options from Des Moines to Mississippi. Find affordable one-way fares based on user searches. Data last updated August 17, 2026.
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:24 am -
1 stop4h 39m
Deal found 8/16![United Airlines logo]()
$140
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:26 pm -
1 stop4h 33m
Deal found 8/14![American Airlines logo]()
$150
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/66:40 am -
2 stops15h 20m
Deal found 8/14![Southwest logo]()
$161
This Southwest deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:15 am -
2 stops10h 00m
Deal found 8/16![Southwest logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/113:54 pm -
2 stops27h 24m
Deal found 8/14![Multiple Airlines logo]()
$175
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/116:55 pm -
1 stop4h 21m
Deal found 8/14![United Airlines logo]()
$179
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:10 am -
1 stop5h 07m
Deal found 8/13![American Airlines logo]()
$213
This United Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:00 am -
2 stops11h 38m
Deal found 8/13![United Airlines logo]()
$254
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/115:35 am -
1 stop5h 41m
Deal found 8/12![Delta logo]()
$268
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/268:03 am -
1 stop5h 16m
Deal found 8/12![American Airlines logo]()
$274
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/83:02 pm -
1 stop4h 58m
Deal found 8/12![United Airlines logo]()
$294
This United Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/261:26 pm -
2 stops8h 12m
Deal found 8/12![United Airlines logo]()
$315
Find flight deals from Des Moines to Mississippi
Keep the following information in mind while searching for Des Moines to Mississippi flight deals. Data was last updated August 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $233 (Delta) |
One-way from | $140 (Delta) |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Mississippi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 17, 2026.
Use the filters below to find and compare flights from Des Moines to Mississippi that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesMemphis
DSM Des Moines - MEM Memphis
DSMMEM
Des Moines
Thu 2/4
7:29 am-1:47 pm
1 stop6h 18m
Memphis
Mon 2/8
2:17 pm-7:09 pm
1 stop4h 52m
$279
Des MoinesMemphis
DSM Des Moines - MEM Memphis
DSMMEM
Des Moines
Wed 9/30
10:59 am-5:59 pm
1 stop7h 00m
Memphis
Wed 10/7
3:35 pm-10:33 pm
1 stop6h 58m
$279
Des MoinesMemphis
DSM Des Moines - MEM Memphis
DSMMEM
Des Moines
Wed 9/30
7:15 am-2:30 pm
1 stop7h 15m
Memphis
Wed 10/7
5:10 am-2:20 pm
2 stops9h 10m
$284
Des MoinesMemphis
DSM Des Moines - MEM Memphis
DSMMEM
Des Moines
Fri 10/2
7:00 am-11:19 am
1 stop4h 19m
Memphis
Mon 10/5
7:18 am-1:49 pm
1 stop6h 31m
$289
Des MoinesMemphis
DSM Des Moines - MEM Memphis
DSMMEM
Des Moines
Thu 2/4
3:10 pm-10:00 pm
1 stop6h 50m
Memphis
Mon 2/8
12:45 pm-9:20 pm
2 stops8h 35m
$304
Des MoinesAlexandria
DSM Des Moines - AEX Alexandria
DSMAEX
Des Moines
Sat 9/26
4:14 pm-10:39 pm
1 stop6h 25m
Alexandria
Sat 10/3
5:15 pm-11:12 pm
1 stop5h 57m
$308
Des MoinesJackson
DSM Des Moines - JAN Jackson-Evers Intl
DSMJAN
Des Moines
Mon 9/14
6:54 pm-11:21 pm
1 stop4h 27m
Jackson-Evers Intl
Mon 9/21
3:02 pm-10:26 pm
1 stop7h 24m
$309
Des MoinesMobile
DSM Des Moines - MOB Mobile
DSMMOB
Des Moines
Tue 11/10
6:50 pm-11:48 pm
1 stop4h 58m
Mobile
Tue 11/17
9:12 am-2:13 pm
1 stop5h 01m
$319
Des MoinesGulfport
DSM Des Moines - GPT Gulfport Biloxi Regional
DSMGPT
Des Moines
Tue 9/22
2:46 pm-10:08 pm
2 stops7h 22m
Gulfport Biloxi Regional
Sat 9/26
4:00 pm-10:26 pm
1 stop6h 26m
$324
Des MoinesMemphis
DSM Des Moines - MEM Memphis
DSMMEM
Des Moines
Fri 11/6
7:26 pm-11:59 pm
1 stop4h 33m
Memphis
Sun 11/8
5:12 am-10:48 am
1 stop5h 36m
$326
Showing 1-10 of 42 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Mississippi
Have a flexible travel schedule? Discover the best time to fly to Mississippi from Des Moines with our price prediction graph.
DSM-MEM
DSM-AEX
DSM-JAN
DSM-MOB
DSM-GPT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Mississippi
DSM-USMS
DSM-MEM
DSM-AEX
DSM-JAN
DSM-MOB
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Mississippi
Get insights into the airlines that provide service to Mississippi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Mississippi. Reviews last updated August 17, 2026.
Peruse reviews from past customers who have flown with United Airlines and American Airlines from Des Moines to Mississippi to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.3
Entertainment
7.1
Crew
8.1
Boarding
7.7
Food
6.7
Overall
7.4
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Comfort
7.3
Entertainment
7.1
Crew
8.1
Boarding
7.7
Food
6.7
Overall
7.4
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Comfort
7.3
Entertainment
7.1
Crew
8.1
Boarding
7.7
Food
6.7
Overall
7.4
Reviews
1 / 20
4.0
OkayChris,Aug 2026
MIA - ORD
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Mississippi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to Mississippi
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Complete your trip
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Des Moines and Mississippi flights
Browse other Des Moines and Mississippi flight options. Last updated on August 17, 2026.
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Des Moines to Mississippi flights
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Top 2 airlines flying from Des Moines to Mississippi
Discover the top 2 airlines that operate flights from Des Moines to Mississippi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$318 | Average$381 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$366 | Average$696 | FlexibilityNo cancel fee | On-time71% |