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Central America

$110+ Cheap flights from Missouri to Central America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/24. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SJO
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Missouri to Central America

Cheapest flights from Missouri to Central America
Explore the most affordable flight options available from Missouri to Central America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:02 pmSTL - SJO
1 stop17h 23mSpirit Airlines
Wed 11/191:30 pmSJO - STL
1 stop20h 28mSpirit Airlines
Deal found 10/28$265
This Cheapflightsfares deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/276:00 amMCI - GUA
1 stop7h 50mSpirit Airlines
Thu 12/43:00 pmGUA - MCI
1 stop8h 15mSpirit Airlines
Deal found 10/29$269
This Orbitz deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/67:01 pmMCI - SJO
1 stop17h 24mSpirit Airlines
Fri 12/1212:39 pmSJO - MCI
1 stop10h 36mSpirit Airlines
Deal found 10/28$284
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/3111:33 amMCI - GUA
2 stops26h 00mMultiple Airlines
Fri 1/301:59 amGUA - MCI
1 stop15h 04mMultiple Airlines
Deal found 10/29$284
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:02 pmSTL - SJO
1 stop17h 23mMultiple Airlines
Wed 11/191:30 pmSJO - STL
2 stops24h 59mMultiple Airlines
Deal found 10/29$295
This Cheapflightsfares deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/156:00 amMCI - GUA
1 stop7h 50mSpirit Airlines
Fri 1/91:59 amGUA - MCI
1 stop15h 04mSpirit Airlines
Deal found 10/29$305
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:15 pmMCI - GUA
1 stop18h 19mSpirit Airlines
Fri 1/301:59 amGUA - MCI
1 stop15h 04mSpirit Airlines
Deal found 10/29$308
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/156:00 amMCI - GUA
2 stops25h 04mMultiple Airlines
Fri 1/91:59 amGUA - MCI
1 stop15h 04mMultiple Airlines
Deal found 10/29$321
This Cheapflightsfares deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/286:00 amMCI - GUA
1 stop7h 50mSpirit Airlines
Fri 12/512:20 pmGUA - MCI
1 stop10h 55mSpirit Airlines
Deal found 10/29$329
This KAYAK deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/236:00 amMCI - GUA
1 stop7h 50mSpirit Airlines
Thu 11/271:38 pmGUA - MCI
1 stop28h 58mSpirit Airlines
Deal found 10/28$332
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2810:57 amSTL - SJO
2 stops25h 28mMultiple Airlines
Wed 1/1412:22 pmSJO - STL
1 stop10h 15mMultiple Airlines
Deal found 10/28$335
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2411:33 amMCI - GUA
2 stops22h 05mMultiple Airlines
Fri 1/91:59 amGUA - MCI
1 stop15h 04mMultiple Airlines
Deal found 10/29$336

Cheap flight deals from Missouri to Central America

Keep the following information in mind while searching for Missouri to Central America flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$265
(Kiwi.com)

One-way from

$110
(Cheapflightsfares)

Popular in

December

Cheapest in

August

Average price

$470
Provider with most accurate pricing for Lambert-St Louis-San Salvador El Salvador Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-San Salvador El Salvador Intl flights.
Search Deals
From Missouri to Central America
Search Deals
One-way flight from Missouri to Central America
Search Deals
Highest demand for flights based on searches. 19% potential increase in price ($144 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Missouri to Central America that are best for you.

Fly from

Missouri

Fly to

Central America

Route

Depart

Return

Price

St. LouisLiberia

STL - LIR

STLLIR

Lambert-St Louis

Tue 1/6

6:00 am-1:50 pm

1 stop7h 50m

Liberia

Tue 1/13

3:05 pm-8:53 am

1 stop17h 48m

$349

St. LouisLiberia

STL - LIR

STLLIR

Lambert-St Louis

Sat 1/10

7:10 am-1:50 pm

1 stop6h 40m

Liberia

Mon 1/12

2:45 pm-11:25 pm

1 stop8h 40m

$349

St. LouisLiberia

STL - LIR

STLLIR

Lambert-St Louis

Thu 1/8

6:00 am-1:50 pm

1 stop7h 50m

Liberia

Fri 1/16

3:05 pm-11:39 pm

1 stop8h 34m

$349

St. LouisLiberia

STL - LIR

STLLIR

Lambert-St Louis

Wed 1/7

6:00 am-1:50 pm

1 stop7h 50m

Liberia

Thu 1/15

2:05 pm-11:39 pm

1 stop9h 34m

$349

St. LouisLiberia

STL - LIR

STLLIR

Lambert-St Louis

Wed 1/7

6:00 am-1:50 pm

1 stop7h 50m

Liberia

Mon 1/12

2:45 pm-11:25 pm

1 stop8h 40m

$349

St. LouisLiberia

STL - LIR

STLLIR

Lambert-St Louis

Sat 1/10

7:10 am-1:50 pm

1 stop6h 40m

Liberia

Sat 1/17

3:05 pm-11:39 pm

1 stop8h 34m

$349

St. LouisLiberia

STL - LIR

STLLIR

Lambert-St Louis

Tue 1/6

6:00 am-1:50 pm

1 stop7h 50m

Liberia

Mon 1/12

2:45 pm-11:25 pm

1 stop8h 40m

$349

St. LouisLiberia

STL - LIR

STLLIR

Lambert-St Louis

Thu 1/8

7:10 am-1:50 pm

1 stop6h 40m

Liberia

Sat 1/17

3:05 pm-8:53 am

1 stop17h 48m

$349

St. LouisLiberia

STL - LIR

STLLIR

Lambert-St Louis

Thu 1/8

6:00 am-12:50 pm

1 stop6h 50m

Liberia

Tue 1/13

3:05 pm-11:39 pm

1 stop8h 34m

$349

St. LouisLiberia

STL - LIR

STLLIR

Lambert-St Louis

Fri 1/9

6:00 am-1:50 pm

1 stop7h 50m

Liberia

Wed 1/14

2:05 pm-11:39 pm

1 stop9h 34m

$349

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to Central America

Have a flexible travel schedule? Discover the best time to fly to Central America from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Central America

What is the cheapest month to book a flight from Missouri to Central America?

Currently, October is the cheapest month in which you can book a flight from Missouri to Central America (average of $162). Flying from Missouri to Central America in July is currently the most expensive (average of $368). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to CA?

Find hourly flight availability from Missouri to Central America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

A simple way to save on the total cost of your ticket is to fly from Missouri to Central America at noon. If you’re flexible enough to do this you can expect to save up to 24% on your trip compared to booking a flight in the morning.

What is the cheapest day to fly from Missouri to Central America?

Use this chart to determine the cheapest time to fly round-trip from Missouri to Central America. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Missouri to Central America flight should consider departing on Wednesday at noon when fares are most often at their lowest. Friday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Central America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Central America?

    For as low as $362, Delta can have you in Central America from Missouri in 7h 20m. The distance between Missouri and Central America is about 1470 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to Central America one-way?

    To fly one-way, consider booking your trip with Spirit Airlines, which is currently one of the cheapest options available, starting at $110. American Airlines flights start at $138 while deals on United Airlines start at $160 one-way.

  • Can I find deals for flights from Missouri to Central America that include hotel bookings?

    Yes. In addition to deals on Missouri to Central America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Central America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Central America.

  • Can I find deals for business class flights from Missouri to Central America?

    Yes. Cheapflights offers flight deals from Missouri to Central America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Central America?

    Currently, October is the cheapest month in which you can book a flight from Missouri to Central America (average of $162). Flying from Missouri to Central America in July is currently the most expensive (average of $368). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Central America

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Top 5 airlines flying from Missouri to Central America

Discover the top 5 airlines that operate flights from Missouri to Central America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$218Average$552FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$263Average$412FlexibilityNo cancel feeOn-time65%
United AirlinesCheapest$287Average$621FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$338Average$626FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$366Average$627FlexibilityNo cancel feeOn-time63%

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