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Central America

$141+ Cheap flights from Missouri to Central America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/29. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — SJO
Jan 14 — Jan 211
Wed 1/14
Wed 1/21
1 adult, Economy
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Cheap flight deals from Missouri to Central America

Cheapest flights from Missouri to Central America
Explore the most affordable flight options available from Missouri to Central America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 15, 2025.

This United Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/146:15 amSTL - LIR
1 stop12h 22mUnited Airlines
Mon 12/2212:30 pmLIR - STL
1 stop10h 13mUnited Airlines
Deal found 12/13$351
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:12 amMCI - BZE
2 stops10h 17mAmerican Airlines
Fri 1/91:22 pmBZE - MCI
2 stops20h 51mAmerican Airlines
Deal found 12/15$441
This Kiwi.com deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:15 pmMCI - GUA
1 stop18h 19mSpirit Airlines
Tue 3/311:28 amGUA - MCI
1 stop7h 55mSpirit Airlines
Deal found 12/12$443
This Delta deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/146:00 amSTL - SJO
1 stop7h 06mDelta
Sun 12/217:00 amSJO - STL
1 stop14h 43mDelta
Deal found 12/13$446
This American Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/146:53 pmSTL - SJO
2 stops19h 03mAmerican Airlines
Mon 12/2212:34 amSJO - STL
1 stop14h 26mAmerican Airlines
Deal found 12/14$450
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1411:34 amSTL - SJO
1 stop11h 25mAmerican Airlines
Sun 12/216:20 amSJO - STL
2 stops14h 31mAmerican Airlines
Deal found 12/13$455
This United Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/136:42 pmSTL - LIR
2 stops18h 28mUnited Airlines
Wed 12/172:20 pmLIR - STL
1 stop7h 38mUnited Airlines
Deal found 12/12$465
This Kiwi.com deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/196:15 pmMCI - BZE
1 stop18h 00mSpirit Airlines
Mon 12/291:10 pmBZE - MCI
1 stop28h 00mSpirit Airlines
Deal found 12/13$468
This American Airlines deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/228:01 pmSTL - BZE
2 stops18h 10mAmerican Airlines
Mon 12/293:11 pmBZE - STL
2 stops17h 24mAmerican Airlines
Deal found 12/13$470
This Kiwi.com deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:15 pmMCI - GUA
1 stop18h 19mSpirit Airlines
Wed 4/11:28 amGUA - MCI
1 stop7h 55mSpirit Airlines
Deal found 12/12$471
This Avianca deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/317:40 amMCI - GUA
1 stop11h 30mMultiple Airlines
Mon 3/307:05 pmGUA - MCI
1 stop18h 45mMultiple Airlines
Deal found 12/12$472
This Expedia deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/198:37 pmSTL - SJO
1 stop12h 44mFrontier
Wed 12/242:52 pmSJO - STL
1 stop18h 48mFrontier
Deal found 12/13$472

Find flight deals from Missouri to Central America

Keep the following information in mind while searching for Missouri to Central America flight deals. Data was last updated December 15, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$304
(Expedia)

One-way from

$141
(Kiwi.com)

Popular in

December

Cheapest in

August

Average price

$1,187
Provider with most accurate pricing for Lambert-St Louis-San Salvador El Salvador Intl flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-San Salvador El Salvador Intl flights.
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From Missouri to Central America
Search Deals
One-way flight from Missouri to Central America
Search Deals
Highest demand for flights based on searches. 27% potential increase in price ($217 potential increase over avg. RT price).
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Cheapest flight prices on average. 10% potential price decrease ($55 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
Use the filters below to find and compare flights from Missouri to Central America that are best for you.

Fly from

Missouri

Fly to

Central America

Route

Depart

Return

Price

Kansas CitySan José

MCI - SJO

MCISJO

Kansas City

Sun 1/18

11:26 am-11:37 am

2 stops24h 11m

San José Juan Santamaria Intl

Thu 1/22

1:30 pm-10:31 am

1 stop21h 01m

$319

St. LouisLiberia

STL - LIR

STLLIR

Lambert-St Louis

Tue 1/20

6:00 am-1:10 pm

1 stop7h 10m

Liberia

Tue 1/27

8:35 am-10:00 pm

1 stop13h 25m

$321

St. LouisBelize City

STL - BZE

STLBZE

Lambert-St Louis

Tue 1/27

6:00 am-12:15 pm

1 stop6h 15m

Belize City Philip S.W.Goldson

Wed 2/4

1:40 pm-8:37 pm

1 stop6h 57m

$334

St. LouisSan José

STL - SJO

STLSJO

Lambert-St Louis

Fri 1/16

8:32 pm-1:42 pm

1 stop17h 10m

San José Juan Santamaria Intl

Sat 1/24

8:05 pm-9:21 am

2 stops37h 16m

$339

St. LouisBelize City

STL - BZE

STLBZE

Lambert-St Louis

Sat 1/24

3:54 pm-12:22 pm

2 stops20h 28m

Belize City Philip S.W.Goldson

Thu 2/5

4:16 pm-9:40 am

2 stops17h 24m

$339

St. LouisBelize City

STL - BZE

STLBZE

Lambert-St Louis

Sat 1/24

3:54 pm-11:49 am

1 stop19h 55m

Belize City Philip S.W.Goldson

Fri 1/30

4:16 pm-9:08 am

1 stop16h 52m

$341

Kansas CitySan José

MCI - SJO

MCISJO

Kansas City

Thu 2/5

11:26 am-12:22 pm

1 stop24h 56m

San José Juan Santamaria Intl

Tue 2/17

1:31 pm-3:29 pm

2 stops25h 58m

$343

Kansas CitySan José

MCI - SJO

MCISJO

Kansas City

Wed 2/18

4:24 pm-11:40 am

1 stop19h 16m

San José Juan Santamaria Intl

Wed 2/25

1:31 pm-10:30 am

1 stop20h 59m

$347

St. LouisLiberia

STL - LIR

STLLIR

Lambert-St Louis

Fri 2/6

5:50 am-2:20 pm

1 stop8h 30m

Liberia

Tue 2/10

3:23 pm-10:59 pm

1 stop7h 36m

$351

St. LouisLiberia

STL - LIR

STLLIR

Lambert-St Louis

Fri 1/9

6:44 pm-12:30 pm

2 stops17h 46m

Liberia

Thu 1/15

3:13 pm-8:51 am

2 stops17h 38m

$355

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/12

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to Central America

Have a flexible travel schedule? Discover the best time to fly to Central America from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Central America

What is the cheapest month to book a flight from Missouri to Central America?

Currently, October is the cheapest month in which you can book a flight from Missouri to Central America (average of $162). Flying from Missouri to Central America in December is currently the most expensive (average of $329). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to CA?

Find hourly flight availability from Missouri to Central America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 15, 2025.

A simple way to save on the total cost of your ticket is to fly from Missouri to Central America in the afternoon. If you’re flexible enough to do this you can expect to save up to 23% on your trip compared to booking a flight in the morning.

What is the cheapest day to fly from Missouri to Central America?

Use this chart to determine the cheapest time to fly round-trip from Missouri to Central America. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Missouri to Central America flight should consider departing on Tuesday evenings when fares are most often at their lowest. Friday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Central America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Central America?

    For as low as $334, Spirit Airlines can have you in Central America from Missouri in 6h 15m. The distance between Missouri and Central America is about 1470 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to Central America one-way?

    To fly one-way, consider booking your trip with Spirit Airlines, which is currently one of the cheapest options available, starting at $85. United Airlines flights start at $129 while deals on Delta start at $131 one-way.

  • Can I find deals for flights from Missouri to Central America that include hotel bookings?

    Yes. In addition to deals on Missouri to Central America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Central America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Central America.

  • Can I find deals for business class flights from Missouri to Central America?

    Yes. Cheapflights offers flight deals from Missouri to Central America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Central America?

    Currently, October is the cheapest month in which you can book a flight from Missouri to Central America (average of $162). Flying from Missouri to Central America in December is currently the most expensive (average of $329). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 5 airlines flying from Missouri to Central America

Discover the top 5 airlines that operate flights from Missouri to Central America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$218Average$551FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$270Average$335FlexibilityNo cancel feeOn-time65%
United AirlinesCheapest$287Average$605FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$319Average$618FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$366Average$629FlexibilityNo cancel feeOn-time63%

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