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Central America

$128+ Cheap flights from Missouri to Central America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/26. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SJO
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Missouri to Central America

Cheapest flights from Missouri to Central America
Explore the most affordable flight options available from Missouri to Central America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/33:49 pm
STL
-
SJO
1 stop19h 51m
Multiple Airlines
Thu 3/512:35 pm
SJO
-
STL
1 stop18h 27m
Multiple Airlines
Deal found 1/27$279
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/233:49 pm
STL
-
SJO
1 stop19h 51m
Multiple Airlines
Wed 2/2512:35 pm
SJO
-
STL
1 stop9h 52m
Multiple Airlines
Deal found 1/27$282
This CheapOair deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/911:26 am
MCI
-
GUA
1 stop24h 58m
Spirit Airlines
Tue 3/1712:59 am
GUA
-
MCI
1 stop8h 24m
Spirit Airlines
Deal found 1/26$284
This CheapOair deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/254:24 pm
MCI
-
SJO
1 stop19h 16m
Spirit Airlines
Wed 3/41:31 pm
SJO
-
MCI
1 stop20h 59m
Spirit Airlines
Deal found 1/27$299
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/174:24 pm
MCI
-
GUA
1 stop18h 56m
Spirit Airlines
Wed 2/181:28 pm
GUA
-
MCI
1 stop21h 02m
Spirit Airlines
Deal found 1/27$303
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:22 pm
STL
-
GUA
2 stops16h 02m
Multiple Airlines
Tue 3/1011:15 am
GUA
-
STL
1 stop11h 04m
Multiple Airlines
Deal found 1/27$305
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/33:49 pm
STL
-
SJO
1 stop19h 51m
Multiple Airlines
Tue 3/1012:31 pm
SJO
-
STL
2 stops21h 06m
Multiple Airlines
Deal found 1/27$305
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/273:49 pm
STL
-
GUA
1 stop19h 31m
Multiple Airlines
Tue 3/1012:28 pm
GUA
-
STL
2 stops21h 09m
Multiple Airlines
Deal found 1/27$308
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:00 am
STL
-
LIR
1 stop6h 50m
Delta
Thu 2/262:45 pm
LIR
-
STL
1 stop8h 38m
Delta
Deal found 1/27$308
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/278:22 pm
STL
-
GUA
2 stops40h 02m
Multiple Airlines
Wed 3/1111:15 am
GUA
-
STL
1 stop11h 04m
Multiple Airlines
Deal found 1/27$310
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:22 pm
STL
-
GUA
2 stops16h 02m
Multiple Airlines
Thu 3/1211:28 am
GUA
-
STL
1 stop18h 54m
Multiple Airlines
Deal found 1/27$315
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/111:26 am
MCI
-
SJO
1 stop24h 56m
Multiple Airlines
Fri 3/612:35 pm
SJO
-
MCI
2 stops31h 20m
Multiple Airlines
Deal found 1/27$315

Find flight deals from Missouri to Central America

Keep the following information in mind while searching for Missouri to Central America flight deals. Data was last updated January 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$279
(Kiwi.com)

One-way from

$128
(Cheapflightsfares)

Popular in

December

Cheapest in

January

Average price

$423
Provider with most accurate pricing for Lambert-St Louis-San Salvador El Salvador Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-San Salvador El Salvador Intl flights.
Search Deals
From Missouri to Central America
Search Deals
One-way flight from Missouri to Central America
Search Deals
Highest demand for flights based on searches. 20% potential increase in price ($156 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 10% potential price decrease ($54 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Missouri to Central America that are best for you.

Fly from

Missouri

Fly to

Central America

Route

Depart

Return

Price

St. LouisSan José

STL - SJO

STLSJO

Lambert-St Louis

Tue 3/3

3:49 pm-11:40 am

1 stop19h 51m

San José Juan Santamaria Intl

Thu 3/5

12:35 pm-7:02 am

1 stop18h 27m

$279

Kansas CityGuatemala City

MCI - GUA

MCIGUA

Kansas City

Mon 3/9

11:26 am-11:24 am

1 stop24h 58m

Guatemala City La Aurora

Tue 3/17

12:59 am-10:23 am

1 stop8h 24m

$294

Kansas CitySan José

MCI - SJO

MCISJO

Kansas City

Wed 2/25

4:24 pm-11:40 am

1 stop19h 16m

San José Juan Santamaria Intl

Wed 3/4

1:31 pm-10:30 am

1 stop20h 59m

$299

Kansas CityGuatemala City

MCI - GUA

MCIGUA

Kansas City

Tue 2/17

4:24 pm-11:20 am

1 stop18h 56m

Guatemala City La Aurora

Wed 2/18

1:28 pm-10:30 am

1 stop21h 02m

$303

St. LouisGuatemala City

STL - GUA

STLGUA

Lambert-St Louis

Mon 3/2

8:22 pm-12:24 pm

2 stops16h 02m

Guatemala City La Aurora

Tue 3/10

11:15 am-11:19 pm

1 stop11h 04m

$305

St. LouisLiberia

STL - LIR

STLLIR

Lambert-St Louis

Sun 2/22

6:55 pm-1:10 pm

2 stops18h 15m

Liberia

Thu 2/26

2:01 pm-10:59 pm

1 stop8h 58m

$308

St. LouisLiberia

STL - LIR

STLLIR

Lambert-St Louis

Sun 2/22

6:00 am-12:50 pm

1 stop6h 50m

Liberia

Thu 2/26

2:45 pm-11:23 pm

1 stop8h 38m

$308

St. LouisGuatemala City

STL - GUA

STLGUA

Lambert-St Louis

Fri 2/27

3:49 pm-11:20 am

1 stop19h 31m

Guatemala City La Aurora

Tue 3/10

12:28 pm-10:37 am

2 stops21h 09m

$308

St. LouisLiberia

STL - LIR

STLLIR

Lambert-St Louis

Sat 4/11

6:53 pm-11:28 am

1 stop17h 35m

Liberia

Wed 4/22

2:10 pm-11:04 pm

1 stop7h 54m

$328

St. LouisLiberia

STL - LIR

STLLIR

Lambert-St Louis

Sun 2/22

6:57 pm-12:37 pm

1 stop17h 40m

Liberia

Thu 2/26

3:13 pm-8:35 am

2 stops17h 22m

$330

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 53 results
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Best time to book a flight from Missouri to Central America

Have a flexible travel schedule? Discover the best time to fly to Central America from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Central America

What is the cheapest month to book a flight from Missouri to Central America?

Currently, October is the cheapest month in which you can book a flight from Missouri to Central America (average of $162). Flying from Missouri to Central America in December is currently the most expensive (average of $329). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Central America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Central America?

    For as low as $308, Spirit Airlines can have you in Central America from Missouri in 6h 50m. The distance between Missouri and Central America is about 1967 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to Central America one-way?

    To fly one-way, consider booking your trip with Spirit Airlines, which is currently one of the cheapest options available, starting at $85. United Airlines flights start at $129 while deals on Delta start at $131 one-way.

  • Can I find deals for flights from Missouri to Central America that include hotel bookings?

    Yes. In addition to deals on Missouri to Central America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Central America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Central America.

  • Can I find deals for business class flights from Missouri to Central America?

    Yes. Cheapflights offers flight deals from Missouri to Central America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Central America?

    Currently, October is the cheapest month in which you can book a flight from Missouri to Central America (average of $162). Flying from Missouri to Central America in December is currently the most expensive (average of $329). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Central America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Missouri to Central America

Discover the top 5 airlines that operate flights from Missouri to Central America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$209Average$530FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$272Average$328FlexibilityNo cancel feeOn-time65%
United AirlinesCheapest$287Average$599FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$319Average$604FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$366Average$620FlexibilityNo cancel feeOn-time63%

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