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Central America

$111+ Cheap flights from Mississippi to Central America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — SJO
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Mississippi to Central America

Cheapest flights from Mississippi to Central America
Explore the most affordable flight options available from Mississippi to Central America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/2511:15 am
MEM
-
SJO
1 stop24h 25m
Multiple Airlines
Wed 3/41:31 pm
SJO
-
MEM
1 stop27h 55m
Multiple Airlines
Deal found 1/26$323
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:01 pm
MEM
-
SJO
1 stop17h 21m
Multiple Airlines
Tue 3/2411:38 am
SJO
-
MEM
1 stop21h 37m
Multiple Airlines
Deal found 1/26$327
This CheapOair deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/1511:15 am
MEM
-
GUA
1 stop24h 05m
Spirit Airlines
Fri 2/2012:15 pm
GUA
-
MEM
1 stop22h 05m
Spirit Airlines
Deal found 1/27$330
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/156:58 pm
MEM
-
GUA
2 stops16h 22m
Multiple Airlines
Fri 2/2012:15 pm
GUA
-
MEM
1 stop22h 05m
Multiple Airlines
Deal found 1/27$332
This American Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:53 am
MEM
-
SJO
2 stops11h 19m
American Airlines
Fri 3/63:59 pm
SJO
-
MEM
1 stop7h 56m
American Airlines
Deal found 1/28$342
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/166:37 pm
MEM
-
SJO
1 stop17h 42m
Multiple Airlines
Tue 3/2411:38 am
SJO
-
MEM
1 stop21h 37m
Multiple Airlines
Deal found 1/27$346
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/187:01 pm
MEM
-
SJO
1 stop17h 24m
American Airlines
Wed 4/226:30 am
SJO
-
MEM
1 stop16h 12m
American Airlines
Deal found 1/27$348
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/226:00 am
MEM
-
LIR
1 stop6h 50m
Delta
Thu 2/263:05 pm
LIR
-
MEM
1 stop8h 18m
Delta
Deal found 1/27$348
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:30 pm
MEM
-
GUA
1 stop20h 04m
Multiple Airlines
Sat 4/2512:29 pm
GUA
-
MEM
1 stop28h 26m
Multiple Airlines
Deal found 1/25$352
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:23 pm
MEM
-
LIR
2 stops17h 09m
American Airlines
Thu 3/51:21 pm
LIR
-
MEM
1 stop10h 34m
American Airlines
Deal found 1/27$353
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/96:00 am
MEM
-
LIR
1 stop7h 50m
Delta
Thu 2/123:05 pm
LIR
-
MEM
1 stop8h 18m
Delta
Deal found 1/26$356
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/225:38 am
MEM
-
LIR
1 stop8h 47m
American Airlines
Thu 2/263:13 pm
LIR
-
MEM
2 stops17h 41m
American Airlines
Deal found 1/27$357

Find flight deals from Mississippi to Central America

Keep the following information in mind while searching for Mississippi to Central America flight deals. Data was last updated January 28, 2026.

Round-trip from

$323
(Kiwi.com)

One-way from

$111
(Kiwi.com)
From Mississippi to Central America
Search Deals
One-way flight from Mississippi to Central America
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Central America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Mississippi to Central America that are best for you.

Fly from

Mississippi

Fly to

Central America

Route

Depart

Return

Price

MemphisSan José

MEM - SJO

MEMSJO

Memphis

Sun 3/1

7:01 pm-12:22 pm

1 stop17h 21m

San José Juan Santamaria Intl

Tue 3/24

11:38 am-10:15 am

1 stop21h 37m

$327

MemphisSan José

MEM - SJO

MEMSJO

Memphis

Mon 3/2

8:53 am-8:12 pm

2 stops11h 19m

San José Juan Santamaria Intl

Fri 3/6

3:59 pm-11:55 pm

1 stop7h 56m

$342

MemphisSan José

MEM - SJO

MEMSJO

Memphis

Sun 4/26

6:15 am-12:21 pm

1 stop7h 06m

San José Juan Santamaria Intl

Wed 4/29

7:55 am-4:15 pm

1 stop7h 20m

$348

MemphisLiberia

MEM - LIR

MEMLIR

Memphis

Sun 2/22

6:00 am-12:50 pm

1 stop6h 50m

Liberia

Thu 2/26

2:05 pm-11:23 pm

1 stop9h 18m

$348

MemphisGuatemala City

MEM - GUA

MEMGUA

Memphis

Mon 4/13

4:30 pm-11:34 am

1 stop20h 04m

Guatemala City La Aurora

Sat 4/25

12:29 pm-5:55 pm

1 stop28h 26m

$352

MemphisLiberia

MEM - LIR

MEMLIR

Memphis

Mon 2/9

6:00 am-1:50 pm

1 stop7h 50m

Liberia

Thu 2/12

3:05 pm-11:23 pm

1 stop8h 18m

$356

MemphisLiberia

MEM - LIR

MEMLIR

Memphis

Tue 5/26

6:50 pm-10:00 am

1 stop16h 10m

Liberia

Wed 6/3

3:27 pm-9:03 am

1 stop16h 36m

$356

MemphisLiberia

MEM - LIR

MEMLIR

Memphis

Sun 2/22

5:00 am-2:13 pm

2 stops9h 13m

Liberia

Thu 2/26

3:13 pm-8:54 am

2 stops17h 41m

$357

MemphisSan José

MEM - SJO

MEMSJO

Memphis

Thu 4/16

6:15 am-12:21 pm

1 stop7h 06m

San José Juan Santamaria Intl

Mon 4/20

7:55 am-9:40 pm

1 stop12h 45m

$368

MemphisLiberia

MEM - LIR

MEMLIR

Memphis

Thu 6/11

6:50 pm-10:00 am

1 stop16h 10m

Liberia

Tue 6/16

3:27 pm-9:03 am

1 stop16h 36m

$376

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 52 results
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Best time to book a flight from Mississippi to Central America

Have a flexible travel schedule? Discover the best time to fly to Central America from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Central America

What is the cheapest month to book a flight from Mississippi to Central America?

Currently, June is the cheapest month in which you can book a flight from Mississippi to Central America (average of $453). Flying from Mississippi to Central America in March is currently the most expensive (average of $599). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Central America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Mississippi to Central America?

    There are many flights that can get you from Mississippi to Central America in 6h 50m. Fly via American Airlines, United Airlines, or Delta to get the fastest option. The distance between Mississippi and Central America is about 1711 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Mississippi to Central America that include hotel bookings?

    Yes. In addition to deals on Mississippi to Central America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Central America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Central America.

  • Can I find deals for business class flights from Mississippi to Central America?

    Yes. Cheapflights offers flight deals from Mississippi to Central America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Central America?

    Currently, June is the cheapest month in which you can book a flight from Mississippi to Central America (average of $453). Flying from Mississippi to Central America in March is currently the most expensive (average of $599). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Mississippi to Central America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Mississippi to Central America

Discover the top 3 airlines that operate flights from Mississippi to Central America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$272Average$704FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$288Average$636FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$471Average$579FlexibilityNo cancel feeOn-time71%

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