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Spartanburg

$117+ Cheap flights from Knoxville (TYS) to Spartanburg, SC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/12. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CLT
Aug 16 — Aug 231
Sun 8/16
Sun 8/23
1 adult, Economy
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Cheap flight deals from Knoxville to Spartanburg

Cheapest flights from Knoxville to Spartanburg
Explore the most affordable flight options available from Knoxville to Spartanburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 17, 2026.

This American Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/87:04 am
TYS
-
CLT
1 stop23h 20m
American Airlines
Sun 8/99:10 am
CLT
-
TYS
Nonstop1h 20m
American Airlines
Deal found 7/13$221
This Southwest deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/127:00 am
TYS
-
CLT
1 stop5h 45m
Southwest
Wed 8/191:30 pm
CLT
-
TYS
1 stop6h 20m
Southwest
Deal found 7/13$233
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:50 am
TYS
-
CLT
1 stop7h 35m
Southwest
Mon 9/76:35 am
CLT
-
TYS
1 stop5h 45m
Southwest
Deal found 7/14$238
This Southwest deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/108:25 am
TYS
-
CLT
1 stop8h 00m
Southwest
Mon 8/1710:35 am
CLT
-
TYS
1 stop8h 00m
Southwest
Deal found 7/13$244
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2510:30 am
TYS
-
CLT
1 stop21h 31m
Multiple Airlines
Fri 8/288:56 am
CLT
-
TYS
1 stop10h 09m
Multiple Airlines
Deal found 7/12$268
This Southwest deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:45 pm
TYS
-
CLT
1 stop4h 05m
Southwest
Mon 8/176:35 am
CLT
-
TYS
1 stop5h 45m
Southwest
Deal found 7/14$285
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/37:20 pm
TYS
-
CLT
2 stops22h 43m
Multiple Airlines
Sun 8/166:41 pm
CLT
-
TYS
1 stop13h 55m
Multiple Airlines
Deal found 7/15$291
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/811:16 am
TYS
-
CLT
1 stop9h 57m
Multiple Airlines
Sun 8/96:41 pm
CLT
-
TYS
1 stop13h 55m
Multiple Airlines
Deal found 7/12$302
This American Airlines deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2410:55 am
TYS
-
CLT
1 stop43h 32m
American Airlines
Mon 10/269:05 am
CLT
-
TYS
Nonstop1h 18m
American Airlines
Deal found 7/12$305
This Southwest deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/247:10 am
TYS
-
CLT
2 stops10h 25m
Southwest
Sun 9/277:10 am
CLT
-
TYS
1 stop3h 45m
Southwest
Deal found 7/15$316

Find flight deals from Knoxville to Spartanburg

Keep the following information in mind while searching for Knoxville to Spartanburg flight deals. Data was last updated July 17, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$221
(American Airlines)

One-way from

$117
(Southwest)

Popular in

March

Cheapest in

June

Average price

$549
Provider with most accurate pricing for Knoxville McGhee Tyson-Charlotte Douglas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Charlotte Douglas flights.
Search Deals
From Knoxville McGhee Tyson to Spartanburg
Search Deals
One-way flight from Knoxville McGhee Tyson to Spartanburg
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($78 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($21 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Spartanburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 17, 2026.
Use the filters below to find and compare flights from Knoxville to Spartanburg that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Tue 8/25

7:00 am-12:45 pm

1 stop5h 45m

Charlotte Douglas

Wed 8/26

6:50 am-12:05 pm

1 stop5h 15m

$233

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Sat 9/5

6:50 am-2:25 pm

1 stop7h 35m

Charlotte Douglas

Mon 9/7

6:35 am-12:20 pm

1 stop5h 45m

$238

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Mon 8/10

8:25 am-4:25 pm

1 stop8h 00m

Charlotte Douglas

Mon 8/17

10:35 am-6:35 pm

1 stop8h 00m

$244
Quickest round-trip

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Thu 8/13

5:45 pm-9:50 pm

1 stop4h 05m

Charlotte Douglas

Mon 8/17

6:35 am-12:20 pm

1 stop5h 45m

$285

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Thu 9/24

7:10 am-5:35 pm

2 stops10h 25m

Charlotte Douglas

Sun 9/27

7:10 am-10:55 am

1 stop3h 45m

$316

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Sat 11/14

6:10 am-9:31 pm

1 stop15h 21m

Charlotte Douglas

Tue 12/1

9:31 am-10:50 am

1 stop25h 19m

$333

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Sat 8/8

5:03 pm-9:56 am

2 stops16h 53m

Charlotte Douglas

Sun 8/9

6:41 pm-8:36 am

1 stop13h 55m

$339

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Sat 8/8

6:50 am-2:25 pm

1 stop7h 35m

Charlotte Douglas

Sun 8/9

1:35 pm-8:45 pm

2 stops7h 10m

$467

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Sun 10/4

6:25 am-3:50 pm

2 stops9h 25m

Charlotte Douglas

Mon 10/5

6:50 am-12:15 pm

1 stop5h 25m

$482
Cheapest one-way

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Wed 10/14

7:15 am-12:35 pm

1 stop5h 20m

$117

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/15

Showing 1-10 of 20 resultsSorted by cheapest first
1
2

Best time to book a flight from Knoxville to Spartanburg

Have a flexible travel schedule? Discover the best time to fly to Spartanburg from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Spartanburg

What is the cheapest time of day to fly from TYS to SB1?

Find hourly flight availability from Knoxville to Spartanburg. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 17, 2026.

When flying from Knoxville to Spartanburg, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 33% versus a flight at noon.

Weekly flight availability from Knoxville to Spartanburg

Explore weekly flight availability from Knoxville to Spartanburg. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated July 17, 2026.

The most flights from TYS to SB1 are scheduled on a Monday (10 on average). You will have fewer flight options on Saturday, which is when the least amount of flights are scheduled (6 on average).

What is the cheapest day to fly from Knoxville to Spartanburg?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Spartanburg. Price data was last updated on July 11, 2026.

Travelers seeking maximum savings on their Knoxville to Spartanburg flight should consider departing on Friday evenings when fares are most often at their lowest. Monday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Spartanburg

Get insights into the airlines that provide service to Spartanburg. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spartanburg. Reviews last updated July 17, 2026.
Read through reviews of airlines operating flights from Knoxville to Spartanburg, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,818 reviews

Boarding

7.5

Comfort

7.2

Crew

7.9

Food

6.4

Overall

7.1

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go
American Airlines
7.1
Good
11,818 reviews
American Airlines
7.1
Good
11,818 reviews

Boarding

7.5

Comfort

7.2

Crew

7.9

Food

6.4

Overall

7.1

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Spartanburg. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Spartanburg?

    If you book a flight to Spartanburg from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 8 flights from McGhee Tyson to Spartanburg per day from 1 airline.

  • How popular is this Knoxville to Spartanburg flight route?

    The Knoxville McGhee Tyson to Spartanburg flight path was viewed by 26 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Knoxville to Spartanburg?

    Airlines like Southwest and American Airlines fly from Knoxville to Spartanburg in about 5h 45m. The time it takes to get you to your destination can typically vary by up to 9h 36m. Airlines will cover a distance of 176 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most reliable airlines from Knoxville to Spartanburg?

    Before booking your flight to Spartanburg from Knoxville, check out the most reliable airlines to get you to your destination on time: Piedmont Airlines (91%), American Airlines (87%), PSA Airlines( 83%).

  • What are the cheapest flights from Knoxville to Spartanburg?

    The cheapest flight price from Knoxville to Spartanburg is $167. On average you can expect to pay $1,077. The most popular route, (Knoxville McGhee Tyson - Charlotte Douglas), can usually be booked for $238.

  • Can I find deals for flights from Knoxville to Spartanburg that include hotel bookings?

    Yes. In addition to deals on Knoxville to Spartanburg flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Spartanburg?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Spartanburg.

  • Can I find deals for business class flights from Knoxville to Spartanburg?

    Yes. Cheapflights offers flight deals from Knoxville to Spartanburg by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Knoxville to Spartanburg

Discover the top airline that operate flights from Knoxville to Spartanburg. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 17, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$296Average$423FlexibilityNo cancel feeOn-time71%

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