$126+ Cheap flights from Knoxville (TYS) to Spartanburg, SC
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/30. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CLT
Oct 5 — Oct 121
Round-trip
1 adult, Economy
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Find cheap flights from Knoxville to Spartanburg with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Spartanburg
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Best
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One-way
Cheapest flights from Knoxville to SpartanburgExplore the most affordable flight options available from Knoxville to Spartanburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 5, 2026.
Explore the most affordable flight options available from Knoxville to Spartanburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 5, 2026.
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:10 am -
1 stop24h 56m
Sun 9/2710:00 am -
Nonstop1h 09m
Deal found 9/1![American Airlines logo]()
$237
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:16 pm -
1 stop24h 51m
Sat 9/269:40 pm -
Nonstop1h 10m
Deal found 9/3![American Airlines logo]()
$242
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:28 pm -
1 stop21h 45m
Mon 11/25:38 pm -
1 stop23h 36m
Deal found 9/4![Multiple Airlines logo]()
$276
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:25 pm -
1 stop3h 25m
Sat 10/2411:35 am -
1 stop6h 20m
Deal found 9/3![Southwest logo]()
$287
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:18 pm -
Nonstop1h 26m
Sat 9/2610:38 pm -
1 stop18h 58m
Deal found 9/3![American Airlines logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/910:07 pm -
1 stop9h 50m
Mon 10/129:29 am -
1 stop12h 02m
Deal found 9/1![Multiple Airlines logo]()
$300
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/263:51 pm -
1 stop16h 44m
Sun 9/278:50 pm -
1 stop22h 44m
Deal found 9/1![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/193:51 pm -
1 stop16h 44m
Mon 9/211:42 pm -
1 stop5h 52m
Deal found 9/2![Multiple Airlines logo]()
$308
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:57 pm -
1 stop19h 35m
Sun 10/255:38 pm -
1 stop25h 46m
Deal found 8/31![Multiple Airlines logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2812:22 pm -
1 stop20h 13m
Mon 10/58:50 am -
1 stop12h 31m
Deal found 8/30![Multiple Airlines logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/144:18 pm -
1 stop16h 17m
Mon 10/51:51 pm -
1 stop7h 30m
Deal found 8/30![Multiple Airlines logo]()
$314
Best flights from Knoxville to SpartanburgDiscover carefully curated flight deals from Knoxville to Spartanburg that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 5, 2026.
Discover carefully curated flight deals from Knoxville to Spartanburg that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 5, 2026.
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:25 pm -
1 stop3h 25m
Sat 10/2411:35 am -
1 stop6h 20m
Deal found 9/3![Southwest logo]()
$287
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:05 pm -
1 stop12h 22m
Thu 10/89:05 am -
Nonstop1h 18m
Deal found 9/1![American Airlines logo]()
$397
This Southwest deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:15 pm -
1 stop3h 45m
Sat 10/1711:35 am -
1 stop6h 20m
Deal found 9/1![Southwest logo]()
$320
This Southwest deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:15 pm -
1 stop3h 45m
Wed 10/141:10 pm -
2 stops7h 55m
Deal found 8/31![Southwest logo]()
$346
This Southwest deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:25 pm -
1 stop3h 15m
Sun 11/86:45 am -
1 stop5h 25m
Deal found 9/4![Southwest logo]()
$363
This Southwest deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/32:55 pm -
1 stop3h 45m
Sun 10/46:35 am -
1 stop5h 35m
Deal found 9/2![Southwest logo]()
$387
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/27:25 pm -
1 stop3h 20m
Sat 10/36:30 am -
1 stop5h 30m
Deal found 9/3![Southwest logo]()
$397
This Southwest deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:45 pm -
1 stop4h 10m
Mon 10/56:50 am -
1 stop5h 25m
Deal found 8/30![Southwest logo]()
$439
Last-minute flights from Knoxville to SpartanburgDiscover last-minute flight deals from Knoxville to Spartanburg. Data last updated September 5, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Spartanburg. Data last updated September 5, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/144:18 pm -
1 stop16h 17m
Mon 10/51:51 pm -
1 stop7h 30m
Deal found 8/30![Multiple Airlines logo]()
$314
This Kiwi.com deal was found by Cheapflights users on 9/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/193:51 pm -
1 stop16h 44m
Mon 9/211:42 pm -
1 stop5h 52m
Deal found 9/2![Multiple Airlines logo]()
$308
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:16 pm -
1 stop24h 51m
Sat 9/269:40 pm -
Nonstop1h 10m
Deal found 9/3![American Airlines logo]()
$242
This American Airlines deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:10 am -
1 stop24h 56m
Sun 9/2710:00 am -
Nonstop1h 09m
Deal found 9/1![American Airlines logo]()
$237
This American Airlines deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:18 pm -
Nonstop1h 26m
Sat 9/2610:38 pm -
1 stop18h 58m
Deal found 9/3![American Airlines logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/263:51 pm -
1 stop16h 44m
Sun 9/278:50 pm -
1 stop22h 44m
Deal found 9/1![Multiple Airlines logo]()
$304
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2812:22 pm -
1 stop20h 13m
Mon 10/58:50 am -
1 stop12h 31m
Deal found 8/30![Multiple Airlines logo]()
$312
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/910:07 pm -
1 stop9h 50m
Mon 10/129:29 am -
1 stop12h 02m
Deal found 9/1![Multiple Airlines logo]()
$300
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/227:25 pm -
1 stop3h 25m
Sat 10/2411:35 am -
1 stop6h 20m
Deal found 9/3![Southwest logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2312:57 pm -
1 stop19h 35m
Sun 10/255:38 pm -
1 stop25h 46m
Deal found 8/31![Multiple Airlines logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/309:28 pm -
1 stop21h 45m
Mon 11/25:38 pm -
1 stop23h 36m
Deal found 9/4![Multiple Airlines logo]()
$276
One-way flights from Knoxville to SpartanburgSearch for one-way flight options from Knoxville to Spartanburg. Find affordable one-way fares based on user searches. Data last updated September 5, 2026.
Search for one-way flight options from Knoxville to Spartanburg. Find affordable one-way fares based on user searches. Data last updated September 5, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3012:57 pm -
1 stop21h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/30![Multiple Airlines logo]()
$126
This Kiwi.com deal was found by Cheapflights users on 9/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/22:12 pm -
1 stop26h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/1![Multiple Airlines logo]()
$128
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3010:28 am -
1 stop22h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Multiple Airlines logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 9/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/41:58 pm -
1 stop18h 41m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/4![Multiple Airlines logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 8/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2812:22 pm -
1 stop20h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/31![Multiple Airlines logo]()
$137
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/297:00 am -
1 stop5h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Southwest logo]()
$144
This Southwest deal was found by Cheapflights users on 9/3. Clicking the “Pick Dates ” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:50 am -
1 stop7h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/3![Southwest logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 8/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/284:14 pm -
1 stop27h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 8/30![Multiple Airlines logo]()
$163
Find flight deals from Knoxville to Spartanburg
Keep the following information in mind while searching for Knoxville to Spartanburg flight deals. Data was last updated September 5, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $237 (American Airlines) |
One-way from | $126 (Kiwi.com) |
Popular in | October |
Cheapest in | June |
Average price | $549 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Spartanburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 5, 2026.
Use the filters below to find and compare flights from Knoxville to Spartanburg that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleCharlotte
TYS Knoxville McGhee Tyson - CLT Charlotte Douglas
TYSCLT
Knoxville McGhee Tyson
Wed 12/2
7:55 am-2:25 pm
1 stop6h 30m
Charlotte Douglas
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$144
KnoxvilleCharlotte
TYS Knoxville McGhee Tyson - CLT Charlotte Douglas
TYSCLT
Knoxville McGhee Tyson
Tue 12/1
7:05 am-12:50 pm
1 stop5h 45m
Charlotte Douglas
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$144
KnoxvilleCharlotte
TYS Knoxville McGhee Tyson - CLT Charlotte Douglas
TYSCLT
Knoxville McGhee Tyson
Sat 10/31
8:25 am-3:15 pm
1 stop6h 50m
Charlotte Douglas
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$144
KnoxvilleCharlotte
TYS Knoxville McGhee Tyson - CLT Charlotte Douglas
TYSCLT
Knoxville McGhee Tyson
Sat 9/26
6:50 am-2:25 pm
1 stop7h 35m
Charlotte Douglas
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$149
KnoxvilleCharlotte
TYS Knoxville McGhee Tyson - CLT Charlotte Douglas
TYSCLT
Knoxville McGhee Tyson
Fri 10/2
5:39 pm-4:42 pm
1 stop23h 03m
Charlotte Douglas
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$186
KnoxvilleCharlotte
TYS Knoxville McGhee Tyson - CLT Charlotte Douglas
TYSCLT
Knoxville McGhee Tyson
Thu 12/3
7:05 am-5:40 pm
2 stops10h 35m
Charlotte Douglas
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$195
Quickest round-trip
KnoxvilleCharlotte
TYS Knoxville McGhee Tyson - CLT Charlotte Douglas
TYSCLT
Knoxville McGhee Tyson
Mon 11/30
7:00 am-12:20 pm
1 stop5h 20m
Charlotte Douglas
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$214
KnoxvilleCharlotte
TYS Knoxville McGhee Tyson - CLT Charlotte Douglas
TYSCLT
Knoxville McGhee Tyson
Thu 10/1
1:37 pm-3:16 pm
3 stops25h 39m
Charlotte Douglas
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$255
KnoxvilleCharlotte
TYS Knoxville McGhee Tyson - CLT Charlotte Douglas
TYSCLT
Knoxville McGhee Tyson
Thu 10/22
7:25 pm-10:50 pm
1 stop3h 25m
Charlotte Douglas
Sat 10/24
11:35 am-5:55 pm
1 stop6h 20m
$287
KnoxvilleCharlotte
TYS Knoxville McGhee Tyson - CLT Charlotte Douglas
TYSCLT
Knoxville McGhee Tyson
Sat 2/27
5:57 pm-10:09 am
2 stops16h 12m
Charlotte Douglas
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$305
Showing 1-10 of 18 resultsSorted by cheapest first
Best time to book a flight from Knoxville to Spartanburg
Have a flexible travel schedule? Discover the best time to fly to Spartanburg from Knoxville with our price prediction graph.
TYS-CLT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Spartanburg
TYS-SB1
TYS-CLT
What is the cheapest time of day to fly from TYS to SB1?
Find hourly flight availability from Knoxville to Spartanburg. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 5, 2026.
When flying from Knoxville to Spartanburg, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 26% versus a flight at noon.
What is the cheapest day to fly from Knoxville to Spartanburg?
Use this chart to determine the cheapest time to fly round-trip from Knoxville to Spartanburg. Price data was last updated on August 29, 2026.
Travelers seeking maximum savings on their Knoxville to Spartanburg flight should consider departing on Friday evenings when fares are most often at their lowest. Sunday at noon flights should be avoided if possible as fares are typically the most expensive at this time.
Reviews of airlines servicing Spartanburg
Get insights into the airlines that provide service to Spartanburg. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spartanburg. Reviews last updated September 5, 2026.
Read through reviews of airlines operating flights from Knoxville to Spartanburg, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Entertainment
6.8
Comfort
7.2
Boarding
7.5
Food
6.4
Overall
7.1
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Crew
7.9
Entertainment
6.8
Comfort
7.2
Boarding
7.5
Food
6.4
Overall
7.1
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Spartanburg. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Spartanburg by adding a car rental and/or hotel reservation to your travel itinerary.
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Knoxville and Spartanburg flights
Browse other Knoxville and Spartanburg flight options. Last updated on September 5, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on September 5, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Knoxville to Spartanburg flights
Consider these flights traveling from Knoxville to Spartanburg.
Top airline flying from Knoxville to Spartanburg
Discover the top airline that operate flights from Knoxville to Spartanburg. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 5, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$489 | Average$561 | FlexibilityNo cancel fee | On-time71% |