$110+ Cheap flights from Spartanburg, SC to Knoxville (TYS)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/5. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — TYS
Sep 7 — Sep 141
Round-trip
1 adult, Economy
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Find cheap flights from Spartanburg to Knoxville with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Spartanburg to Knoxville
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Best
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One-way
Cheapest flights from Spartanburg to KnoxvilleExplore the most affordable flight options available from Spartanburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 8, 2026.
Explore the most affordable flight options available from Spartanburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2210:02 pm -
1 stop14h 12m
Sun 10/256:00 am -
1 stop7h 47m
Deal found 8/6![Multiple Airlines logo]()
$250
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:35 am -
1 stop5h 45m
Mon 9/145:45 pm -
1 stop4h 10m
Deal found 8/4![Southwest logo]()
$251
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/189:52 pm -
1 stop17h 07m
Sat 8/223:57 pm -
1 stop16h 04m
Deal found 8/4![Multiple Airlines logo]()
$266
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/21:30 pm -
1 stop6h 20m
Wed 9/97:00 am -
1 stop5h 45m
Deal found 8/3![Southwest logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/199:46 am -
1 stop24h 18m
Tue 8/2510:30 am -
1 stop21h 31m
Deal found 8/7![Multiple Airlines logo]()
$272
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:30 pm -
1 stop6h 25m
Thu 9/107:10 am -
2 stops10h 25m
Deal found 8/6![Southwest logo]()
$280
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:35 am -
1 stop5h 45m
Thu 9/177:10 am -
1 stop5h 15m
Deal found 8/3![Southwest logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:38 pm -
1 stop14h 57m
Fri 10/96:55 pm -
2 stops17h 43m
Deal found 8/4![Multiple Airlines logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/198:08 pm -
1 stop13h 56m
Sat 9/266:55 pm -
1 stop25h 00m
Deal found 8/6![Multiple Airlines logo]()
$308
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:35 am -
1 stop5h 45m
Sun 9/138:30 am -
1 stop6h 05m
Deal found 8/4![Southwest logo]()
$310
Best flights from Spartanburg to KnoxvilleDiscover carefully curated flight deals from Spartanburg to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 8, 2026.
Discover carefully curated flight deals from Spartanburg to Knoxville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 8, 2026.
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/21:30 pm -
1 stop6h 20m
Wed 9/97:00 am -
1 stop5h 45m
Deal found 8/3![Southwest logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/38:56 am -
1 stop8h 25m
Mon 9/78:30 am -
1 stop23h 31m
Deal found 8/6![Multiple Airlines logo]()
$348
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:35 am -
1 stop5h 45m
Thu 9/175:45 pm -
1 stop4h 10m
Deal found 8/4![Southwest logo]()
$269
This United Airlines deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2610:25 am -
1 stop24h 12m
Sat 8/295:45 am -
1 stop13h 11m
Deal found 8/4![United Airlines logo]()
$561
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/201:10 pm -
1 stop6h 55m
Fri 10/237:25 pm -
1 stop3h 20m
Deal found 8/3![Southwest logo]()
$289
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/121:00 pm -
1 stop4h 45m
Mon 9/145:45 pm -
1 stop4h 10m
Deal found 8/3![Southwest logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/141:48 pm -
1 stop8h 56m
Sun 8/162:56 pm -
2 stops16h 55m
Deal found 8/5![Multiple Airlines logo]()
$584
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:00 am -
2 stops16h 59m
Sun 9/65:45 am -
1 stop8h 33m
Deal found 8/6![United Airlines logo]()
$599
This United Airlines deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1210:25 am -
2 stops12h 24m
Mon 9/145:45 am -
1 stop18h 14m
Deal found 8/6![United Airlines logo]()
$626
This Southwest deal was found by Cheapflights users on 8/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/111:30 pm -
1 stop6h 20m
Wed 8/125:30 pm -
1 stop3h 55m
Deal found 8/5![Southwest logo]()
$614
Last-minute flights from Spartanburg to KnoxvilleDiscover last-minute flight deals from Spartanburg to Knoxville. Data last updated August 8, 2026 and is based on user searches.
Discover last-minute flight deals from Spartanburg to Knoxville. Data last updated August 8, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/189:52 pm -
1 stop17h 07m
Sat 8/223:57 pm -
1 stop16h 04m
Deal found 8/4![Multiple Airlines logo]()
$266
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/199:46 am -
1 stop24h 18m
Tue 8/2510:30 am -
1 stop21h 31m
Deal found 8/7![Multiple Airlines logo]()
$272
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/21:30 pm -
1 stop6h 20m
Wed 9/97:00 am -
1 stop5h 45m
Deal found 8/3![Southwest logo]()
$269
This Southwest deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:30 pm -
1 stop6h 25m
Thu 9/107:10 am -
2 stops10h 25m
Deal found 8/6![Southwest logo]()
$280
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:35 am -
1 stop5h 45m
Thu 9/177:10 am -
2 stops10h 25m
Deal found 8/4![Southwest logo]()
$300
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:35 am -
1 stop5h 45m
Mon 9/145:45 pm -
1 stop4h 10m
Deal found 8/4![Southwest logo]()
$251
This Southwest deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:35 am -
1 stop5h 45m
Sun 9/138:30 am -
1 stop6h 05m
Deal found 8/4![Southwest logo]()
$310
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:38 pm -
1 stop16h 36m
Mon 9/147:04 pm -
2 stops21h 38m
Deal found 8/4![Multiple Airlines logo]()
$322
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/121:00 pm -
1 stop4h 45m
Mon 9/145:45 pm -
1 stop4h 10m
Deal found 8/3![Southwest logo]()
$289
This Kiwi.com deal was found by Cheapflights users on 8/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/198:08 pm -
1 stop13h 56m
Sat 9/266:55 pm -
1 stop25h 00m
Deal found 8/6![Multiple Airlines logo]()
$308
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/255:38 pm -
1 stop19h 26m
Mon 9/285:33 pm -
1 stop15h 02m
Deal found 8/3![Multiple Airlines logo]()
$314
One-way flights from Spartanburg to KnoxvilleSearch for one-way flight options from Spartanburg to Knoxville. Find affordable one-way fares based on user searches. Data last updated August 8, 2026.
Search for one-way flight options from Spartanburg to Knoxville. Find affordable one-way fares based on user searches. Data last updated August 8, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/59:46 am -
1 stop24h 18m
Deal found 8/7![Multiple Airlines logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/89:46 am -
1 stop24h 18m
Deal found 8/8![Multiple Airlines logo]()
$118
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:38 pm -
1 stop14h 57m
Deal found 8/3![Multiple Airlines logo]()
$133
This Kiwi.com deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1510:02 pm -
1 stop25h 03m
Deal found 8/7![Multiple Airlines logo]()
$134
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/21:30 pm -
1 stop6h 20m
Deal found 8/3![Southwest logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/19:46 am -
1 stop24h 18m
Deal found 8/3![Multiple Airlines logo]()
$138
This Kiwi.com deal was found by Cheapflights users on 8/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/29:46 am -
1 stop24h 18m
Deal found 8/4![Multiple Airlines logo]()
$145
This Southwest deal was found by Cheapflights users on 8/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/37:55 am -
2 stops9h 55m
Deal found 8/3![Southwest logo]()
$146
Find flight deals from Spartanburg to Knoxville
Keep the following information in mind while searching for Spartanburg to Knoxville flight deals. Data was last updated August 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $250 (Kiwi.com) |
One-way from | $110 (Kiwi.com) |
Popular in | June |
Cheapest in | April |
Cheapflights Fare Finder
Customize your flight search to find flights from Spartanburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 8, 2026.
Use the filters below to find and compare flights from Spartanburg to Knoxville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
CharlotteKnoxville
CLT Charlotte Douglas - TYS Knoxville McGhee Tyson
CLTTYS
Charlotte Douglas
Wed 9/2
1:30 pm-7:50 pm
1 stop6h 20m
Knoxville McGhee Tyson
Wed 9/9
7:00 am-12:45 pm
1 stop5h 45m
$269
CharlotteKnoxville
CLT Charlotte Douglas - TYS Knoxville McGhee Tyson
CLTTYS
Charlotte Douglas
Thu 9/10
6:35 am-12:20 pm
1 stop5h 45m
Knoxville McGhee Tyson
Thu 9/17
5:45 pm-9:55 pm
1 stop4h 10m
$269
CharlotteKnoxville
CLT Charlotte Douglas - TYS Knoxville McGhee Tyson
CLTTYS
Charlotte Douglas
Tue 10/20
1:10 pm-8:05 pm
1 stop6h 55m
Knoxville McGhee Tyson
Fri 10/23
7:25 pm-10:45 pm
1 stop3h 20m
$289
Quickest round-trip
CharlotteKnoxville
CLT Charlotte Douglas - TYS Knoxville McGhee Tyson
CLTTYS
Charlotte Douglas
Sat 9/12
1:00 pm-5:45 pm
1 stop4h 45m
Knoxville McGhee Tyson
Mon 9/14
5:45 pm-9:55 pm
1 stop4h 10m
$289
CharlotteKnoxville
CLT Charlotte Douglas - TYS Knoxville McGhee Tyson
CLTTYS
Charlotte Douglas
Thu 9/3
8:56 am-5:21 pm
1 stop8h 25m
Knoxville McGhee Tyson
Mon 9/7
8:30 am-8:01 am
1 stop23h 31m
$348
CharlotteKnoxville
CLT Charlotte Douglas - TYS Knoxville McGhee Tyson
CLTTYS
Charlotte Douglas
Wed 8/26
10:25 am-10:37 am
1 stop24h 12m
Knoxville McGhee Tyson
Sat 8/29
5:45 am-6:56 pm
1 stop13h 11m
$561
CharlotteKnoxville
CLT Charlotte Douglas - TYS Knoxville McGhee Tyson
CLTTYS
Charlotte Douglas
Fri 8/14
1:48 pm-10:44 pm
1 stop8h 56m
Knoxville McGhee Tyson
Sun 8/16
2:56 pm-7:51 am
2 stops16h 55m
$584
CharlotteKnoxville
CLT Charlotte Douglas - TYS Knoxville McGhee Tyson
CLTTYS
Charlotte Douglas
Thu 9/3
7:00 am-11:59 pm
2 stops16h 59m
Knoxville McGhee Tyson
Sun 9/6
5:45 am-2:18 pm
1 stop8h 33m
$599
CharlotteKnoxville
CLT Charlotte Douglas - TYS Knoxville McGhee Tyson
CLTTYS
Charlotte Douglas
Tue 8/11
1:30 pm-7:50 pm
1 stop6h 20m
Knoxville McGhee Tyson
Wed 8/12
5:30 pm-9:25 pm
1 stop3h 55m
$614
CharlotteKnoxville
CLT Charlotte Douglas - TYS Knoxville McGhee Tyson
CLTTYS
Charlotte Douglas
Sat 9/12
10:25 am-10:49 pm
2 stops12h 24m
Knoxville McGhee Tyson
Mon 9/14
5:45 am-11:59 pm
1 stop18h 14m
$626
Showing 1-10 of 21 resultsSorted by cheapest first
Best time to book a flight from Spartanburg to Knoxville
Have a flexible travel schedule? Discover the best time to fly to Knoxville from Spartanburg with our price prediction graph.
CLT-TYS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Spartanburg to Knoxville
SB1-TYS
CLT-TYS
What is the cheapest time of day to fly from SB1 to TYS?
Find hourly flight availability from Spartanburg to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 8, 2026.
It’s typically best to fly out from Spartanburg to Knoxville in the morning. Doing so could potentially save you 27% on the flight price compared to flying in the evening, which is usually more expensive.
Reviews of airlines servicing Knoxville
Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated August 8, 2026.
Read reviews from past customers who have flown American Airlines from Spartanburg to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Food
6.4
Entertainment
6.8
Comfort
7.2
Boarding
7.5
Overall
7.1
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Crew
7.9
Food
6.4
Entertainment
6.8
Comfort
7.2
Boarding
7.5
Overall
7.1
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Spartanburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Knoxville?
Book flights to Knoxville if you plan to visit one of these locationsCherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
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Spartanburg and Knoxville flights
Browse other Spartanburg and Knoxville flight options. Last updated on August 8, 2026.
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Consider these flights traveling from Spartanburg to Knoxville.
Top airline flying from Spartanburg to Knoxville
Discover the top airline that operate flights from Spartanburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$487 | Average$555 | FlexibilityNo cancel fee | On-time71% |