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$74+ Cheap flights from Spartanburg, SC to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/16. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — TYS
Jun 23 — Jun 301
Tue 6/23
Tue 6/30
1 adult, Economy
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Cheap flight deals from Spartanburg to Knoxville

Cheapest flights from Spartanburg to Knoxville
Explore the most affordable flight options available from Spartanburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 24, 2026.

This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/157:45 pm
CLT
-
TYS
1 stop4h 09m
Delta
Wed 6/175:40 am
TYS
-
CLT
1 stop3h 13m
Delta
Deal found 5/20$147
This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/49:41 am
CLT
-
TYS
1 stop4h 52m
Delta
Mon 6/87:46 pm
TYS
-
CLT
1 stop4h 13m
Delta
Deal found 5/20$157
This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/15:35 am
CLT
-
TYS
1 stop3h 59m
Delta
Fri 6/51:59 pm
TYS
-
CLT
1 stop6h 15m
Delta
Deal found 5/20$217
This Kiwi.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:41 pm
CLT
-
TYS
1 stop15h 45m
Multiple Airlines
Thu 8/138:29 pm
TYS
-
CLT
1 stop24h 38m
Multiple Airlines
Deal found 5/24$219
This Kiwi.com deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:41 pm
CLT
-
TYS
1 stop15h 45m
Multiple Airlines
Sun 8/97:45 am
TYS
-
CLT
1 stop13h 22m
Multiple Airlines
Deal found 5/22$261
This Kiwi.com deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/810:02 pm
CLT
-
TYS
1 stop22h 19m
Multiple Airlines
Tue 7/145:00 pm
TYS
-
CLT
1 stop28h 07m
Multiple Airlines
Deal found 5/23$294
This Southwest deal was found by Cheapflights users on 5/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/91:30 pm
CLT
-
TYS
1 stop6h 20m
Southwest
Wed 9/167:00 am
TYS
-
CLT
1 stop5h 45m
Southwest
Deal found 5/22$295
This Southwest deal was found by Cheapflights users on 5/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/810:40 am
CLT
-
TYS
2 stops9h 45m
Southwest
Tue 7/146:55 pm
TYS
-
CLT
1 stop3h 15m
Southwest
Deal found 5/23$300
This Kiwi.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:41 pm
CLT
-
TYS
1 stop15h 45m
Multiple Airlines
Sun 8/168:29 pm
TYS
-
CLT
1 stop24h 38m
Multiple Airlines
Deal found 5/24$303
This Kiwi.com deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:41 pm
CLT
-
TYS
1 stop15h 45m
Multiple Airlines
Mon 8/106:29 pm
TYS
-
CLT
1 stop17h 00m
Multiple Airlines
Deal found 5/24$310
This Southwest deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:50 am
CLT
-
TYS
1 stop5h 15m
Southwest
Fri 7/106:40 am
TYS
-
CLT
1 stop5h 55m
Southwest
Deal found 5/19$316

Find flight deals from Spartanburg to Knoxville

Keep the following information in mind while searching for Spartanburg to Knoxville flight deals. Data was last updated May 24, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$147
(Delta)

One-way from

$74
(Delta)

Popular in

May

Cheapest in

April

Average price

$642
Provider with most accurate pricing for Charlotte Douglas-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charlotte Douglas-Knoxville McGhee Tyson flights.
Search Deals
From Spartanburg to Knoxville McGhee Tyson
Search Deals
One-way flight from Spartanburg to Knoxville McGhee Tyson
Search Deals
High demand for flights, 32% potential price rise
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Spartanburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 24, 2026.
Use the filters below to find and compare flights from Spartanburg to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Thu 7/9

5:30 am-9:36 am

1 stop4h 06m

Knoxville McGhee Tyson

Thu 7/9

3:54 pm-8:18 pm

1 stop4h 24m

$147

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sat 8/22

5:30 pm-10:39 pm

1 stop5h 09m

Knoxville McGhee Tyson

Sun 8/30

5:19 am-8:52 am

1 stop3h 33m

$147

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Tue 6/9

5:39 pm-11:54 pm

1 stop6h 15m

Knoxville McGhee Tyson

Tue 6/16

5:40 am-8:53 am

1 stop3h 13m

$152

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Tue 7/7

10:40 am-8:20 pm

2 stops9h 40m

Knoxville McGhee Tyson

Fri 7/10

7:45 pm-11:15 pm

1 stop3h 30m

$321

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 7/10

4:00 pm-9:15 pm

1 stop5h 15m

Knoxville McGhee Tyson

Tue 7/14

7:10 am-3:40 pm

2 stops8h 30m

$321
Quickest round-trip

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sat 8/22

1:00 pm-5:40 pm

1 stop4h 40m

Knoxville McGhee Tyson

Sun 8/30

5:55 pm-9:35 pm

1 stop3h 40m

$329

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sat 6/20

1:05 pm-9:20 pm

1 stop8h 15m

Knoxville McGhee Tyson

Mon 6/22

7:45 pm-11:15 pm

1 stop3h 30m

$342

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 8/7

1:05 pm-7:55 pm

1 stop6h 50m

Knoxville McGhee Tyson

Sun 8/9

7:35 am-5:55 pm

2 stops10h 20m

$348

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sat 6/20

6:35 am-11:55 am

1 stop5h 20m

Knoxville McGhee Tyson

Sat 6/27

6:55 pm-10:10 pm

1 stop3h 15m

$357

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Thu 6/18

1:10 pm-10:30 pm

1 stop9h 20m

Knoxville McGhee Tyson

Thu 6/25

7:45 pm-11:15 pm

1 stop3h 30m

$362

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/20

Showing 1-10 of 22 resultsSorted by cheapest first
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2
3

Best time to book a flight from Spartanburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Spartanburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Knoxville

What is the cheapest time of day to fly from SB1 to TYS?

Find hourly flight availability from Spartanburg to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 24, 2026.

It’s typically best to fly out from Spartanburg to Knoxville in the morning. Doing so could potentially save you 5% on the flight price compared to flying in the evening, which is usually more expensive.

Weekly flight availability from Spartanburg to Knoxville

Explore weekly flight availability from Spartanburg to Knoxville. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated May 24, 2026.

The most flights from SB1 to TYS are scheduled on a Friday (11 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (6 on average).

How much does it cost to fly round-trip from Spartanburg to Knoxville?

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated May 24, 2026.
Read reviews from past customers who have flown American Airlines from Spartanburg to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,631 reviews

Overall

7.1

Entertainment

6.9

Crew

7.9

Food

6.4

Boarding

7.5

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Anonymous,Apr 2026

DFW - BDL

They keep changing the gate, delaying the hours and then finally canceled it. No accomodation, no food, nothing!
American Airlines
7.1
Good
11,631 reviews
American Airlines
7.1
Good
11,631 reviews

Overall

7.1

Entertainment

6.9

Crew

7.9

Food

6.4

Boarding

7.5

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Anonymous,Apr 2026

DFW - BDL

They keep changing the gate, delaying the hours and then finally canceled it. No accomodation, no food, nothing!

Related info for your journey

Find useful and relevant information for your journey from Spartanburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Spartanburg?

    Knoxville McGhee Tyson (TYS), located 11.3 mi from the city center, is the airport you fly into when you book flights from Spartanburg to Knoxville. 1 airline have flights to McGhee Tyson from Spartanburg on a regular basis. Booking flights from Spartanburg to Knoxville McGhee Tyson should not be difficult; the airport handles an average of 9 inbound flights from Spartanburg per day.

  • How long is the flight from Spartanburg to Knoxville?

    For as low as $147, Delta can have you in Knoxville from Spartanburg in 4h 06m. There are 176 mi between Spartanburg and Knoxville. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most reliable airlines from Spartanburg to Knoxville?

    The top 3 most reliable airlines when flying from Spartanburg to Knoxville are Piedmont Airlines (90%), British Airways (83%) and American Airlines (81%).

  • What are the cheapest flights from Spartanburg to Knoxville?

    On average you can expect to pay $388 for a flight from Spartanburg to Knoxville. The cheapest flight overall is $388 while the most popular route, (Charlotte Douglas - Knoxville McGhee Tyson) is currently priced at $261.

  • Can I find deals for flights from Spartanburg to Knoxville that include hotel bookings?

    Yes. In addition to deals on Spartanburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Spartanburg to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Knoxville.

  • Can I find deals for business class flights from Spartanburg to Knoxville?

    Yes. Cheapflights offers flight deals from Spartanburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa
Oak Ridge

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Top airline flying from Spartanburg to Knoxville

Discover the top airline that operate flights from Spartanburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 24, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$487Average$549FlexibilityNo cancel feeOn-time71%

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