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Knoxville

$117+ Cheap flights from Spartanburg, SC to Knoxville (TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/11. Fares are subject to change and may not be available on all flights or dates of travel.
CLT — TYS
Aug 20 — Aug 271
Thu 8/20
Thu 8/27
1 adult, Economy
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Cheap flight deals from Spartanburg to Knoxville

Cheapest flights from Spartanburg to Knoxville
Explore the most affordable flight options available from Spartanburg to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 21, 2026.

This Southwest deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:50 am
CLT
-
TYS
1 stop5h 15m
Southwest
Wed 8/267:00 am
TYS
-
CLT
1 stop5h 45m
Southwest
Deal found 7/20$233
This Kiwi.com deal was found by Cheapflights users on 7/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/58:56 am
CLT
-
TYS
1 stop10h 57m
Multiple Airlines
Sun 9/610:54 am
TYS
-
CLT
1 stop9h 49m
Multiple Airlines
Deal found 7/18$258
This Southwest deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/181:30 pm
CLT
-
TYS
1 stop6h 20m
Southwest
Tue 8/255:30 pm
TYS
-
CLT
1 stop3h 55m
Southwest
Deal found 7/19$259
This Kiwi.com deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/171:48 pm
CLT
-
TYS
1 stop8h 56m
Multiple Airlines
Mon 8/242:51 pm
TYS
-
CLT
1 stop17h 10m
Multiple Airlines
Deal found 7/20$276
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:41 pm
CLT
-
TYS
1 stop13h 55m
Multiple Airlines
Thu 8/204:52 pm
TYS
-
CLT
1 stop27h 51m
Multiple Airlines
Deal found 7/16$283
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/19:46 am
CLT
-
TYS
1 stop24h 18m
Multiple Airlines
Sun 9/610:54 am
TYS
-
CLT
1 stop9h 49m
Multiple Airlines
Deal found 7/16$284
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/116:35 am
CLT
-
TYS
1 stop5h 45m
Southwest
Sun 9/135:55 pm
TYS
-
CLT
1 stop3h 40m
Southwest
Deal found 7/17$285
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/19:46 am
CLT
-
TYS
1 stop24h 18m
Multiple Airlines
Thu 9/1010:54 am
TYS
-
CLT
1 stop9h 01m
Multiple Airlines
Deal found 7/16$286
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:41 pm
CLT
-
TYS
1 stop21h 32m
Multiple Airlines
Thu 8/204:52 pm
TYS
-
CLT
1 stop27h 51m
Multiple Airlines
Deal found 7/16$291
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/29:46 am
CLT
-
TYS
1 stop24h 18m
Multiple Airlines
Thu 9/1010:54 am
TYS
-
CLT
1 stop9h 01m
Multiple Airlines
Deal found 7/16$293
This Kiwi.com deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/42:45 pm
CLT
-
TYS
1 stop8h 11m
Multiple Airlines
Sun 9/610:54 am
TYS
-
CLT
1 stop9h 49m
Multiple Airlines
Deal found 7/17$294
This Southwest deal was found by Cheapflights users on 7/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/176:35 am
CLT
-
TYS
1 stop5h 45m
Southwest
Tue 8/185:30 pm
TYS
-
CLT
1 stop3h 55m
Southwest
Deal found 7/17$298

Find flight deals from Spartanburg to Knoxville

Keep the following information in mind while searching for Spartanburg to Knoxville flight deals. Data was last updated July 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$233
(Southwest)

One-way from

$117
(Southwest)

Popular in

June

Cheapest in

April

Average price

$617
Provider with most accurate pricing for Charlotte Douglas-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charlotte Douglas-Knoxville McGhee Tyson flights.
Search Deals
From Spartanburg to Knoxville McGhee Tyson
Search Deals
One-way flight from Spartanburg to Knoxville McGhee Tyson
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($96 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Spartanburg to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 21, 2026.
Use the filters below to find and compare flights from Spartanburg to Knoxville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Wed 8/19

6:50 am-12:05 pm

1 stop5h 15m

Knoxville McGhee Tyson

Wed 8/26

7:00 am-12:45 pm

1 stop5h 45m

$233

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 9/11

6:35 am-12:20 pm

1 stop5h 45m

Knoxville McGhee Tyson

Fri 9/11

5:45 pm-9:50 pm

1 stop4h 05m

$233

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Mon 8/17

6:35 am-12:20 pm

1 stop5h 45m

Knoxville McGhee Tyson

Tue 8/18

5:30 pm-9:25 pm

1 stop3h 55m

$298
Quickest round-trip

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Sat 9/5

6:30 am-11:55 am

1 stop5h 25m

Knoxville McGhee Tyson

Sun 9/6

6:10 pm-9:30 pm

1 stop3h 20m

$305

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 8/14

6:35 am-12:20 pm

1 stop5h 45m

Knoxville McGhee Tyson

Thu 8/20

7:10 am-5:35 pm

2 stops10h 25m

$316

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 9/4

2:45 pm-10:56 pm

1 stop8h 11m

Knoxville McGhee Tyson

Mon 9/7

2:30 pm-8:01 am

1 stop17h 31m

$352

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Wed 8/19

9:46 am-10:04 am

1 stop24h 18m

Knoxville McGhee Tyson

Wed 8/26

3:49 pm-8:11 pm

2 stops28h 22m

$443

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Mon 8/3

6:35 am-12:00 pm

1 stop5h 25m

Knoxville McGhee Tyson

Thu 8/6

7:10 am-5:35 pm

2 stops10h 25m

$448

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 9/4

10:35 am-6:35 pm

1 stop8h 00m

Knoxville McGhee Tyson

Mon 9/7

7:10 am-5:35 pm

2 stops10h 25m

$463

CharlotteKnoxville

CLT - TYS

CLTTYS

Charlotte Douglas

Fri 7/31

1:10 pm-10:35 pm

1 stop9h 25m

Knoxville McGhee Tyson

Sun 8/2

7:05 am-5:20 pm

2 stops10h 15m

$467

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/17

Showing 1-10 of 21 resultsSorted by cheapest first
1
2
3

Best time to book a flight from Spartanburg to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Spartanburg with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Spartanburg to Knoxville

What is the cheapest time of day to fly from SB1 to TYS?

Find hourly flight availability from Spartanburg to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 21, 2026.

It’s typically best to fly out from Spartanburg to Knoxville in the morning. Doing so could potentially save you 27% on the flight price compared to flying in the evening, which is usually more expensive.

Weekly flight availability from Spartanburg to Knoxville

Explore weekly flight availability from Spartanburg to Knoxville. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated July 21, 2026.

The most flights from SB1 to TYS are scheduled on a Monday (11 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (8 on average).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated July 21, 2026.
Read reviews from past customers who have flown American Airlines from Spartanburg to Knoxville. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,826 reviews

Comfort

7.2

Entertainment

6.8

Food

6.4

Crew

7.9

Overall

7.1

Boarding

7.5

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go
American Airlines
7.1
Good
11,826 reviews
American Airlines
7.1
Good
11,826 reviews

Comfort

7.2

Entertainment

6.8

Food

6.4

Crew

7.9

Overall

7.1

Boarding

7.5

Reviews

1 / 20
10.0
Excellent

Linda,Jul 2026

ROA - CLT

Very helpful and friendly people who pushed me where I needed to go

Related info for your journey

Find useful and relevant information for your journey from Spartanburg to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Knoxville from Spartanburg?

    Knoxville McGhee Tyson (TYS), located 11.3 mi from the city center, is the airport you fly into when you book flights from Spartanburg to Knoxville. 1 airline have flights to McGhee Tyson from Spartanburg on a regular basis. Booking flights from Spartanburg to Knoxville McGhee Tyson should not be difficult; the airport handles an average of 9 inbound flights from Spartanburg per day.

  • How long is the flight from Spartanburg to Knoxville?

    For as low as $233, Southwest can have you in Knoxville from Spartanburg in 5h 15m. There are 176 mi between Spartanburg and Knoxville.

  • What are the most reliable airlines from Spartanburg to Knoxville?

    The top 3 most reliable airlines when flying from Spartanburg to Knoxville are Piedmont Airlines (86%), American Airlines (76%) and SkyWest Airlines (72%).

  • Can I find deals for flights from Spartanburg to Knoxville that include hotel bookings?

    Yes. In addition to deals on Spartanburg to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Spartanburg to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Spartanburg to Knoxville.

  • Can I find deals for business class flights from Spartanburg to Knoxville?

    Yes. Cheapflights offers flight deals from Spartanburg to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Cherokee
Crossville
Morristown
Bryson City
Murphy
Alcoa

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Top airline flying from Spartanburg to Knoxville

Discover the top airline that operate flights from Spartanburg to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$487Average$555FlexibilityNo cancel feeOn-time71%

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