HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South America

$194+ Cheap flights from St. Louis (STL) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BOG
Feb 14 — Feb 211
Sat 2/14
Sat 2/21
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from St. Louis to South America with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from St. Louis to South America

Keep the following information in mind while searching for St. Louis to South America flight deals. Data was last updated January 15, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$344
(Kiwi.com)

One-way from

$194
(Kiwi.com)

Popular in

January

Cheapest in

April

Average price

$1,454
Provider with most accurate pricing for Lambert-St Louis-Sao Paulo (SAO) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Sao Paulo (SAO) flights.
Search Deals
From Lambert-St Louis to South America
Search Deals
One-way flight from Lambert-St Louis to South America
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($174 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($25 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Find flight deals from St. Louis to South America

Cheapest flights from St. Louis to South America
Explore the most affordable flight options available from St. Louis to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 15, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/163:49 pm
STL
-
MDE
1 stop21h 06m
Multiple Airlines
Fri 2/272:50 pm
MDE
-
STL
1 stop10h 37m
Multiple Airlines
Deal found 1/14$344
This Kiwi.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/35:42 pm
STL
-
MDE
1 stop19h 13m
Multiple Airlines
Wed 2/252:50 pm
MDE
-
STL
1 stop8h 37m
Multiple Airlines
Deal found 1/14$366
This Kiwi.com deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/173:49 pm
STL
-
MDE
1 stop21h 06m
Multiple Airlines
Sat 2/282:50 pm
MDE
-
STL
1 stop10h 09m
Multiple Airlines
Deal found 1/14$432
This Avianca deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/38:30 am
STL
-
CTG
2 stops14h 10m
Avianca
Tue 2/108:00 pm
CTG
-
STL
2 stops15h 13m
Avianca
Deal found 1/14$510
This CheapOair deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/288:30 am
STL
-
MDE
2 stops25h 25m
Multiple Airlines
Sun 5/318:20 pm
MDE
-
STL
2 stops23h 44m
Multiple Airlines
Deal found 1/14$561
This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/245:02 am
STL
-
CTG
1 stop7h 23m
American Airlines
Sat 5/301:25 pm
CTG
-
STL
2 stops19h 06m
American Airlines
Deal found 1/13$562
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/285:14 am
STL
-
CTG
1 stop9h 16m
American Airlines
Sat 3/74:30 pm
CTG
-
STL
1 stop18h 02m
American Airlines
Deal found 1/14$565
This CheapOair deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/264:49 pm
STL
-
MDE
2 stops15h 16m
Avianca
Sun 2/110:45 pm
MDE
-
STL
2 stops36h 28m
Avianca
Deal found 1/13$566
This American Airlines deal was found by Cheapflights users on 1/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/206:57 pm
STL
-
CTG
2 stops19h 18m
American Airlines
Wed 3/251:27 pm
CTG
-
STL
2 stops19h 08m
American Airlines
Deal found 1/12$572
This KAYAK deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:00 am
STL
-
MDE
1 stop15h 10m
Copa Airlines
Tue 4/289:45 am
MDE
-
STL
1 stop12h 43m
Copa Airlines
Deal found 1/14$576
This KAYAK deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/177:45 am
STL
-
MDE
2 stops13h 25m
Multiple Airlines
Tue 4/289:45 am
MDE
-
STL
1 stop12h 43m
Multiple Airlines
Deal found 1/14$581
This American Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/35:14 am
STL
-
MDE
1 stop14h 56m
American Airlines
Tue 3/1012:20 am
MDE
-
STL
1 stop17h 20m
American Airlines
Deal found 1/13$591

Cheapflights Fare Finder

 
Customize your flight search to find flights from St. Louis to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
Use the filters below to find and compare flights from St. Louis to South America that are best for you.

Fly from

St. Louis

Fly to

South America

Route

Depart

Return

Price

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Mon 2/16

3:49 pm-1:55 pm

1 stop21h 06m

Medellín Jose Maria Cordova Intl

Fri 2/27

2:50 pm-12:27 am

1 stop10h 37m

$344

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Tue 2/3

5:42 pm-1:55 pm

1 stop19h 13m

Medellín Jose Maria Cordova Intl

Wed 2/25

9:48 am-10:27 pm

2 stops13h 39m

$390

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Tue 2/17

3:49 pm-1:55 pm

1 stop21h 06m

Medellín Jose Maria Cordova Intl

Sat 2/28

2:50 pm-11:59 pm

1 stop10h 09m

$432

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Tue 2/3

8:30 am-11:40 pm

2 stops14h 10m

Cartagena Rafael Nunez

Tue 2/10

8:00 pm-10:13 am

2 stops15h 13m

$510

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Wed 1/28

8:30 am-10:55 am

2 stops25h 25m

Medellín Jose Maria Cordova Intl

Sun 5/31

8:20 pm-8:04 pm

2 stops23h 44m

$561

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Fri 4/17

4:05 pm-12:32 pm

2 stops20h 27m

Medellín Jose Maria Cordova Intl

Tue 4/28

4:01 pm-3:24 pm

2 stops23h 23m

$566

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Sat 2/28

6:53 pm-1:30 pm

2 stops17h 37m

Cartagena Rafael Nunez

Sat 3/7

4:30 pm-9:32 am

1 stop18h 02m

$570

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Fri 3/20

6:57 pm-2:15 pm

2 stops19h 18m

Cartagena Rafael Nunez

Wed 3/25

3:15 pm-11:58 pm

1 stop8h 43m

$572

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Tue 3/3

5:14 am-9:10 pm

1 stop14h 56m

Medellín Jose Maria Cordova Intl

Tue 3/10

12:20 am-5:40 pm

1 stop17h 20m

$591

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Sun 3/22

6:57 pm-2:15 pm

2 stops19h 18m

Cartagena Rafael Nunez

Thu 3/26

1:27 pm-8:35 am

2 stops19h 08m

$605

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/14

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from St. Louis to South America

Have a flexible travel schedule? Discover the best time to fly to South America from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to South America

What is the cheapest month to book a flight from St. Louis to South America?

Currently, October is the cheapest month in which you can book a flight from St. Louis to South America (average of $307). Flying from St. Louis to South America in December is currently the most expensive (average of $568). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated January 15, 2026.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and United Airlines from St. Louis to South America to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,052 reviews

Food

7.2

Entertainment

7.8

Boarding

8.1

Overall

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,052 reviews
Delta
7.9
Good
8,052 reviews

Food

7.2

Entertainment

7.8

Boarding

8.1

Overall

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,906 reviews
Delta
7.9
Good
8,052 reviews

Food

7.2

Entertainment

7.8

Boarding

8.1

Overall

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
United Airlines
7.4
Good
9,164 reviews
Delta
7.9
Good
8,052 reviews

Food

7.2

Entertainment

7.8

Boarding

8.1

Overall

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,136 reviews
Delta
7.9
Good
8,052 reviews

Food

7.2

Entertainment

7.8

Boarding

8.1

Overall

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Air Canada
7.1
Good
10,625 reviews
Delta
7.9
Good
8,052 reviews

Food

7.2

Entertainment

7.8

Boarding

8.1

Overall

7.9

Crew

8.5

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from St. Louis to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from St. Louis to South America?

    Located just 12.7 mi from the city center, Lambert-St Louis (STL) is the airport most travelers will use when flying to South America from St. Louis.

  • How long is the flight from St. Louis to South America?

    A quick flight from St. Louis to South America can take about 14h 10m. Avianca provides one of the quickest options available for as low as $510. Airlines will cover a distance of 2159 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from St. Louis to South America one-way?

    $289 is the cheapest one-way deal found within the past few days, from American Airlines. You may also be able to find cheap deals on LATAM Airlines and Delta, with prices starting from $322 and $360, respectively.

  • What are the most popular routes from St. Louis to South America?

    The most popular flight routes from St. Louis to South America are Lambert-St Louis - Sao Paulo Guarulhos Intl, Lambert-St Louis - Medellín Jose Maria Cordova Intl and Lambert-St Louis - Santiago Arturo Merino Benitez.

  • Can I find deals for flights from St. Louis to South America that include hotel bookings?

    Yes. In addition to deals on St. Louis to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to South America.

  • Can I find deals for business class flights from St. Louis to South America?

    Yes. Cheapflights offers flight deals from St. Louis to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to South America?

    Currently, October is the cheapest month in which you can book a flight from St. Louis to South America (average of $307). Flying from St. Louis to South America in December is currently the most expensive (average of $568). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for St. Louis to South America

See prices for flight routes from nearby airports that may be better suited for you.
St. Louis to Orlando flights
St. Louis to Las Vegas flights
St. Louis to Miami flights
Kansas City to Sky Harbor Intl flights
Kansas City to Las Vegas flights
St. Louis to Denver flights
Kansas City to Denver flights
St. Louis to Sky Harbor Intl flights
Kansas City to Cancún flights
St. Louis to Cancún flights
Kansas City to Seattle flights
Kansas City to Los Angeles flights
St. Louis to LaGuardia flights
Kansas City to Orlando flights
St. Louis to Dallas/Fort Worth flights
St. Louis to Fort Lauderdale flights
St. Louis to Los Angeles flights
St. Louis to Hobby flights
Kansas City to LaGuardia flights
Kansas City to Miami flights
St. Louis to Newark flights
Kansas City to O'Hare Intl flights
Kansas City to Hobby flights
St. Louis to Seattle flights
Kansas City to John F Kennedy Intl flights
Kansas City to Dallas/Fort Worth flights
St. Louis to John F Kennedy Intl flights
St. Louis to George Bush Intcntl flights
Kansas City to Atlanta flights
St. Louis to Dulles Intl flights
Kansas City to George Bush Intcntl flights
Kansas City to Tampa flights
Kansas City to Cozumel flights
Kansas City to Newark flights
Kansas City to Fort Lauderdale flights
St. Louis to San Diego flights
Kansas City to Boston flights
St. Louis to Tampa flights
St. Louis to Fort Myers flights
Kansas City to San Diego flights
St. Louis to San Francisco flights
St. Louis to Boston flights
Kansas City to San Francisco flights
St. Louis to Cozumel flights
St. Louis to Salt Lake City flights
St. Louis to Honolulu flights
St. Louis to New Orleans flights
St. Louis to Reagan-National flights
St. Louis to Baltimore flights
Kansas City to Ontario flights

Top 5 airlines flying from St. Louis to South America

Discover the top 5 airlines that operate flights from St. Louis to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$474Average$861FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$474Average$911FlexibilityNo cancel feeOn-time71%
DeltaCheapest$484Average$1,021FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$536Average$945FlexibilityNo cancel feeOn-time81%
Air CanadaCheapest$758Average$767FlexibilityNo cancel feeOn-time67%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
©2026 Cheapflights