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$484+ Cheap flights from St. Louis (STL) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SCL
jul. 7 — jul. 141
lun. 7/7
lun. 7/14
1 adult, Economy
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Cheapflights Tip: The best prices from Lambert-St Louis to Santiago Arturo Merino Benitez are usually found in October or July, booked 49 days in advance, depart on a Wednesday or Monday and return on a Tuesday

Cheap flight deals from St. Louis to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated julio 2, 2025.

Round-trip from

$884
(Delta)

One-way from

$484
(eDestinos)

Popular in

December

Cheapest in

October

Average price

$898
From Lambert-St Louis to Santiago Arturo Merino Benitez
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One-way flight from Lambert-St Louis to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 5% potential increase in price ($55 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($20 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from St. Louis to Santiago

Cheapest flights from St. Louis to Santiago
Explore the most affordable flight options available from St. Louis to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 2, 2025.

This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/17:20 amSTL - SCL
2 stops21h 35mDelta
vie. 11/2112:30 amSCL - STL
2 stops20h 32mDelta
Deal found 6/30$884
This American Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/110:23 amSTL - SCL
2 stops20h 42mAmerican Airlines
sáb. 11/2211:15 pmSCL - STL
1 stop13h 39mAmerican Airlines
Deal found 7/2$888
This LATAM Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/119:00 amSTL - SCL
2 stops17h 35mLATAM Airlines
lun. 12/157:15 amSCL - STL
3 stops19h 24mLATAM Airlines
Deal found 6/29$908
This Mytrip deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/152:30 pmSTL - SCL
3 stops31h 00mMultiple Airlines
vie. 8/226:10 amSCL - STL
3 stops34h 11mMultiple Airlines
Deal found 7/1$1,233
This Copa Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 7/38:00 amSTL - SCL
2 stops20h 04mCopa Airlines
mar. 7/811:27 amSCL - STL
2 stops23h 32mCopa Airlines
Deal found 7/2$1,344
This Air Canada deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/254:05 pmSTL - SCL
2 stops59h 55mAir Canada
sáb. 1/1012:45 amSCL - STL
2 stops41h 44mAir Canada
Deal found 7/1$2,357

Cheapflights Fare Finder

Customize your flight search to find flights from St. Louis to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 2, 2025.
Use the filters below to find and compare flights from St. Louis to Santiago that are best for you.

Fly from

St. Louis

Fly to

Santiago

Route

Depart

Return

Price

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

sáb. 11/1

7:20 am-6:55 am

2 stops21h 35m

Santiago Arturo Merino Benitez

vie. 11/21

12:30 am-6:02 pm

2 stops20h 32m

$884

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

sáb. 11/1

10:23 am-9:05 am

2 stops20h 42m

Santiago Arturo Merino Benitez

sáb. 11/22

11:15 pm-9:54 am

1 stop13h 39m

$888

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

jue. 12/11

9:00 am-5:35 am

2 stops17h 35m

Santiago Arturo Merino Benitez

lun. 12/15

7:15 am-11:39 pm

3 stops19h 24m

$908

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

vie. 8/15

2:30 pm-10:30 pm

3 stops31h 00m

Santiago Arturo Merino Benitez

vie. 8/22

6:10 am-3:21 pm

3 stops34h 11m

$1,233

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

jue. 12/25

4:05 pm-7:00 am

2 stops59h 55m

Santiago Arturo Merino Benitez

sáb. 1/10

12:45 am-3:29 pm

2 stops41h 44m

$2,357

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

mar. 7/15

5:40 pm-2:25 am

2 stops31h 45m

$484

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

mar. 7/15

10:46 am-6:30 am

2 stops18h 44m

$586

St. LouisSantiago

STL - SCL

STLSCL

Lambert-St Louis

mar. 7/15

3:41 pm-7:00 am

1 stop14h 19m

$593

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/1

Best time to book a flight from St. Louis to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from St. Louis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from St. Louis to Santiago

How far ahead should I book a flight from St. Louis to Santiago?

Use this chart to determine the optimal time to book a round-trip flight from St. Louis to Santiago. Price data was last updated on June 27, 2025.

To ensure you get the cheapest price possible for a flight from St. Louis to Santiago, you should look to book at least 49 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from St. Louis to Santiago?

Currently, April is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $752). Flying from St. Louis to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from STL to SCL?

Find hourly flight availability from St. Louis to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 2, 2025.

A simple way to save on the total cost of your ticket is to fly from St. Louis to Santiago at noon. If you’re flexible enough to do this you can expect to save up to 9% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated julio 2, 2025.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and American Airlines from St. Louis to Santiago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,975 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,975 reviews
Delta
8.0
Very good
7,975 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,805 reviews
Delta
8.0
Very good
7,975 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,975 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Air Canada
7.1
Good
9,671 reviews
Delta
8.0
Very good
7,975 reviews

Crew

8.5

Overall

8.0

Boarding

8.2

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from St. Louis to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from St. Louis to Santiago round-trip?

    Flying on Delta is currently your cheapest option to Santiago, with prices starting at $884. Additional round-trip tickets that might be worth considering are offered by American Airlines and LATAM Airlines, with the lowest prices starting at $888 and $908, respectively. These flights start at 9% lower than the current average price 3 months from now.

  • Can I find deals for flights from St. Louis to Santiago that include hotel bookings?

    Yes. In addition to deals on St. Louis to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from St. Louis to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from St. Louis to Santiago.

  • Can I find deals for business class flights from St. Louis to Santiago?

    Yes. Cheapflights offers flight deals from St. Louis to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from St. Louis to Santiago?

    Currently, April is the cheapest month in which you can book a flight from St. Louis to Santiago (average of $752). Flying from St. Louis to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for St. Louis to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
Kansas City to Santiago flights
Springfield to Santiago flights
St. Louis to Easter Island flights
Kansas City to Balmaceda flights

Top 4 airlines flying from St. Louis to Santiago

Discover the top 4 airlines that operate flights from St. Louis to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$742Average$994FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$762Average$986FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$822Average$992FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$883Average$1,002FlexibilityNo cancel feeOn-time69%

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