What are the cheapest airlines flying from Santiago to St. Louis round-trip?

According to our current data, American Airlines ($953), Delta ($980), and LATAM Airlines ($1,102) offers the cheapest pricing from Santiago to St. Louis. You may be able to fly from Santiago to St. Louis for 5% less than the average price by searching for these airlines.

What is the cheapest month to book a flight from Santiago to St. Louis?

Currently, August is the cheapest month in which you can book a flight from Santiago to St. Louis (average of $311). Flying from Santiago to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest day to fly from Santiago to St. Louis?

Travelers seeking maximum savings on their Santiago to St. Louis flight should consider departing on Tuesday evenings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

What is the cheapest day to fly round-trip from Santiago to St. Louis?

Users have found that leaving on a Monday can be a cost-effective option. It’s possible to save up to 34% on your flight compared to booking on days when demand is much higher.

What is the cheapest month to fly from Santiago to St. Louis?

Flights from Santiago to St. Louis lean towards being more expensive in March. Prices are generally better when you fly from Santiago to St. Louis in November, with the cheapest ticket starting at $784.

What is the cheapest time of day to fly from SCL to STL?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Santiago to St. Louis as you normally would.

Most accurate provider : When it comes to deals on Santiago-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santiago-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santiago-St. Louis flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Santiago-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Santiago to St. Louis that include hotel bookings?

Yes. In addition to deals on Santiago to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Santiago to St. Louis?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to St. Louis.

Can I find deals for business class flights from Santiago to St. Louis?

Yes. Cheapflights offers flight deals from Santiago to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$953+ Flights from Santiago to St. Louis - Compare & Save Big

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1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Santiago to St. Louis

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$953 (American Airlines)
Popular in	March
Cheapest in	November
Average price	$1,065

Provider with most accurate pricing for Santiago Arturo Merino Benitez-Lambert-St Louis flight deals.

Search Deals

Provider most trusted by Cheapflights users for Santiago Arturo Merino Benitez-Lambert-St Louis flights.

Search Deals

From Santiago Arturo Merino Benitez to Lambert-St Louis

Search Deals

Highest demand for flights based on searches. 2% potential increase in price ($30 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($25 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in May 2025

Search Deals

Find flight deals from Santiago to St. Louis

Cheapest flights from Santiago to St. Louis
Explore the most affordable flight options available from Santiago to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 7, 2025.

Thu 6/59:55 pmSCL - STL

2 stops19h 20mAmerican Airlines

Mon 8/2510:08 amSTL - SCL

2 stops19h 57mAmerican Airlines

Deal found 5/6

$953

Tue 7/811:00 amSCL - STL

2 stops23h 41mDelta

Mon 7/147:00 amSTL - SCL

2 stops19h 30mDelta

Deal found 5/6

$980

Thu 6/193:35 amSCL - STL

2 stops34h 01mMultiple Airlines

Fri 6/276:36 pmSTL - SCL

3 stops42h 09mMultiple Airlines

Deal found 5/6

$1,055

Wed 6/412:30 amSCL - STL

2 stops24h 08mLATAM Airlines

Mon 6/96:00 amSTL - SCL

1 stop24h 00mLATAM Airlines

Deal found 5/5

$1,102

Thu 6/192:24 amSCL - STL

2 stops17h 58mCopa Airlines

Fri 6/278:00 amSTL - SCL

2 stops20h 04mCopa Airlines

Deal found 5/6

$1,364

Best flights from Santiago to St. Louis
Discover carefully curated flight deals from Santiago to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 7, 2025.

Thu 6/59:55 pmSCL - STL

2 stops19h 20mAmerican Airlines

Mon 8/2510:08 amSTL - SCL

2 stops19h 57mAmerican Airlines

Deal found 5/6

$953

Tue 7/811:00 amSCL - STL

2 stops23h 41mDelta

Mon 7/147:00 amSTL - SCL

2 stops19h 30mDelta

Deal found 5/6

$980

Thu 6/193:35 amSCL - STL

2 stops34h 01mMultiple Airlines

Fri 6/276:36 pmSTL - SCL

3 stops42h 09mMultiple Airlines

Deal found 5/6

$1,055

Wed 6/412:30 amSCL - STL

2 stops24h 08mLATAM Airlines

Mon 6/96:00 amSTL - SCL

1 stop24h 00mLATAM Airlines

Deal found 5/5

$1,102

Thu 6/192:24 amSCL - STL

2 stops17h 58mCopa Airlines

Fri 6/278:00 amSTL - SCL

2 stops20h 04mCopa Airlines

Deal found 5/6

$1,364

Last-minute flights from Santiago to St. Louis
Discover last-minute flight deals from Santiago to St. Louis. Data last updated May 7, 2025 and is based on user searches.

Wed 5/1412:30 amSCL - STL

2 stops20h 28mMultiple Airlines

Fri 5/237:30 amSTL - SCL

2 stops28h 55mMultiple Airlines

Deal found 5/6

$1,610

Thu 5/1510:55 pmSCL - STL

2 stops18h 52mDelta

Fri 5/2310:05 amSTL - SCL

2 stops19h 25mDelta

Deal found 5/6

$1,265

Thu 5/1511:20 pmSCL - STL

2 stops19h 41mLATAM Airlines

Fri 5/236:00 amSTL - SCL

3 stops24h 35mLATAM Airlines

Deal found 5/6

$1,278

Thu 5/159:00 pmSCL - STL

1 stop21h 29mAmerican Airlines

Fri 5/236:20 pmSTL - SCL

1 stop11h 35mAmerican Airlines

Deal found 5/6

$2,268

Wed 6/412:30 amSCL - STL

2 stops24h 08mLATAM Airlines

Mon 6/96:00 amSTL - SCL

1 stop24h 00mLATAM Airlines

Deal found 5/5

$1,102

Thu 6/59:55 pmSCL - STL

2 stops19h 20mAmerican Airlines

Mon 8/2510:08 amSTL - SCL

2 stops19h 57mAmerican Airlines

Deal found 5/6

$953

Thu 6/193:35 amSCL - STL

2 stops34h 01mMultiple Airlines

Fri 6/276:36 pmSTL - SCL

3 stops42h 09mMultiple Airlines

Deal found 5/6

$1,055

Thu 6/192:24 amSCL - STL

2 stops17h 58mCopa Airlines

Fri 6/278:00 amSTL - SCL

2 stops20h 04mCopa Airlines

Deal found 5/6

$1,364

Fri 6/208:40 pmSCL - STL

1 stop16h 48mDelta

Fri 6/279:28 amSTL - SCL

2 stops20h 22mDelta

Deal found 5/6

$1,020

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santiago to St. Louis that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Thu 6/5

9:55 pm-4:15 pm

2 stops19h 20m

Lambert-St Louis

Mon 8/25

10:08 am-7:05 am

2 stops19h 57m

$953

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Tue 7/8

11:00 am-9:41 am

2 stops23h 41m

Lambert-St Louis

Mon 7/14

7:00 am-3:30 am

2 stops19h 30m

$980

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Thu 6/19

3:35 am-12:36 pm

2 stops34h 01m

Lambert-St Louis

Fri 6/27

6:36 pm-1:45 pm

3 stops42h 09m

$1,055

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 6/4

12:30 am-11:38 pm

2 stops24h 08m

Lambert-St Louis

Mon 6/9

6:00 am-7:00 am

1 stop24h 00m

$1,102

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Thu 6/19

2:24 am-7:22 pm

2 stops17h 58m

Lambert-St Louis

Fri 6/27

8:00 am-5:04 am

2 stops20h 04m

$1,364

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/6

Compare providers for flights from Santiago to St. Louis

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to St. Louis in May.

Provider	Price Accuracy	Trust Score*
eDreams	Price Accuracy3 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*2 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Santiago-St. Louis flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Santiago-St. Louis flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Santiago-St. Louis flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Santiago-St. Louis flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santiago to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Santiago with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Santiago to St. Louis

Rainfall in St. Louis by month

In terms of precipitation, rainfall in St. Louis ranges from 2.2 - 4.7 inches per month. May is typically the wettest month, when rainfall can reach 4.7 in. February is typically the driest time to visit St. Louis when rainfall is around 2.2 in.

Temperature in St. Louis by month

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

Get a feel of what it's like to fly with Delta, LATAM Airlines and Copa Airlines from Santiago to St. Louis by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,944 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,944 reviews

Delta

8.0

Very good

7,944 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

LATAM Airlines

7.5

Good

1,771 reviews

Delta

8.0

Very good

7,944 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Copa Airlines

7.5

Good

1,418 reviews

Delta

8.0

Very good

7,944 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,944 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What are the cheapest airlines flying from Santiago to St. Louis round-trip?
According to our current data, American Airlines ($953), Delta ($980), and LATAM Airlines ($1,102) offers the cheapest pricing from Santiago to St. Louis. You may be able to fly from Santiago to St. Louis for 5% less than the average price by searching for these airlines.
Can I find deals for flights from Santiago to St. Louis that include hotel bookings?
Yes. In addition to deals on Santiago to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Santiago to St. Louis?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to St. Louis.
Can I find deals for business class flights from Santiago to St. Louis?
Yes. Cheapflights offers flight deals from Santiago to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Santiago to St. Louis?
Currently, August is the cheapest month in which you can book a flight from Santiago to St. Louis (average of $311). Flying from Santiago to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Fenton

Maryland Heights

Fairview Heights

Collinsville

Wentzville

Eureka

St. Peters

Festus

Glencoe

Alton

Farmington

O'Fallon

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Complete your trip

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Other flights to St. Louis

Top 2 airlines flying from Santiago to St. Louis

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$782	Average$1,120	FlexibilityNo cancel fee	On-time71%
Delta	Cheapest$843	Average$1,019	FlexibilityNo cancel fee	On-timeN/A

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$953+ Cheap flights from Santiago (SCL) to St. Louis (STL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/5. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Santiago to St. Louis with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Santiago to St. Louis

Most accurate provider

Most trusted provider

Round-trip from

Popular in

Cheapest in

Average price

Find flight deals from Santiago to St. Louis

Cheapest flights from Santiago to St. LouisExplore the most affordable flight options available from Santiago to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 7, 2025.

Explore the most affordable flight options available from Santiago to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 7, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Santiago to St. Louis that are best for you.

Compare providers for flights from Santiago to St. Louis

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Santiago to St. Louis in May.

Best time to book a flight from Santiago to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Santiago with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Santiago to St. Louis

Rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average rainfall totals by month.

Temperature in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature totals by month.

Reviews of airlines servicing St. Louis

Get a feel of what it's like to fly with Delta, LATAM Airlines and Copa Airlines from Santiago to St. Louis by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Santiago to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Santiago to St. Louis round-trip?

Can I find deals for flights from Santiago to St. Louis that include hotel bookings?

How can I find direct flights from Santiago to St. Louis?

Can I find deals for business class flights from Santiago to St. Louis?

What is the cheapest month to book a flight from Santiago to St. Louis?

Traveling to a place near Santiago?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.

Top 2 airlines flying from Santiago to St. Louis

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Travel Smart

Cheapest flights from Santiago to St. Louis
Explore the most affordable flight options available from Santiago to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 7, 2025.