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St. Louis

$795+ Cheap flights from Santiago (SCL) to St. Louis (STL)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/14. Fares are subject to change and may not be available on all flights or dates of travel.
SCL — STL
Feb 20 — Feb 271
Fri 2/20
Fri 2/27
1 adult, Economy
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Cheap flight deals from Santiago to St. Louis

Cheapest flights from Santiago to St. Louis
Explore the most affordable flight options available from Santiago to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2026.

This LATAM Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/1412:40 am
SCL
-
STL
2 stops18h 22m
LATAM Airlines
Wed 8/51:30 pm
STL
-
SCL
2 stops16h 25m
LATAM Airlines
Deal found 1/19$795
This Delta deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/158:40 pm
SCL
-
STL
1 stop20h 17m
Delta
Wed 8/511:51 am
STL
-
SCL
1 stop18h 24m
Delta
Deal found 1/19$816
This LATAM Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/14:30 pm
SCL
-
STL
2 stops26h 32m
LATAM Airlines
Wed 7/811:51 am
STL
-
SCL
2 stops28h 34m
LATAM Airlines
Deal found 1/21$826
This American Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/38:30 pm
SCL
-
STL
2 stops19h 45m
American Airlines
Wed 5/2012:27 pm
STL
-
SCL
2 stops17h 28m
American Airlines
Deal found 1/20$863
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/38:40 pm
SCL
-
STL
1 stop16h 26m
Delta
Wed 5/206:00 am
STL
-
SCL
1 stop24h 15m
Delta
Deal found 1/21$881
This SmartFares deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/211:10 pm
SCL
-
STL
1 stop14h 52m
LATAM Airlines
Fri 4/1010:12 am
STL
-
SCL
1 stop20h 03m
LATAM Airlines
Deal found 1/21$888
This Delta deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/211:25 pm
SCL
-
STL
2 stops18h 22m
Delta
Fri 4/107:03 am
STL
-
SCL
1 stop23h 12m
Delta
Deal found 1/21$889
This OneTravel deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure OneTravel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/38:40 pm
SCL
-
STL
1 stop12h 50m
LATAM Airlines
Wed 5/201:30 pm
STL
-
SCL
1 stop16h 45m
LATAM Airlines
Deal found 1/21$897

Find flight deals from Santiago to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Santiago (SCL) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 21, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
1 star

Round-trip from

$792
(LATAM Airlines)

Popular in

March

Cheapest in

August

Average price

$1,150
Provider with most accurate pricing for Santiago Arturo Merino Benitez-Lambert-St Louis flight deals.
Search Deals
Provider most trusted by Cheapflights users for Santiago Arturo Merino Benitez-Lambert-St Louis flights.
Search Deals
From Santiago Arturo Merino Benitez to Lambert-St Louis
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($107 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($25 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Santiago to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Santiago to St. Louis that are best for you.

Fly from

Santiago

Fly to

St. Louis

Route

Depart

Return

Price

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Wed 7/15

8:40 pm-3:57 pm

1 stop20h 17m

Lambert-St Louis

Wed 8/5

11:51 am-7:15 am

1 stop18h 24m

$816

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Sun 5/3

8:30 pm-3:15 pm

2 stops19h 45m

Lambert-St Louis

Wed 5/20

12:27 pm-6:55 am

2 stops17h 28m

$863

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Sun 5/3

8:40 pm-11:33 pm

1 stop27h 53m

Lambert-St Louis

Wed 5/20

6:00 am-7:15 am

1 stop24h 15m

$881

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Mon 3/2

11:10 pm-11:02 am

1 stop14h 52m

Lambert-St Louis

Fri 4/10

10:12 am-7:15 am

1 stop20h 03m

$888

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Mon 3/2

11:25 pm-2:47 pm

2 stops18h 22m

Lambert-St Louis

Fri 4/10

7:03 am-7:15 am

1 stop23h 12m

$889

SantiagoSt. Louis

SCL - STL

SCLSTL

Santiago Arturo Merino Benitez

Sun 5/3

8:40 pm-8:30 am

1 stop12h 50m

Lambert-St Louis

Wed 5/20

1:30 pm-7:15 am

1 stop16h 45m

$897

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/19

  • Most accurate provider: When it comes to deals on Santiago-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Santiago-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Santiago-St. Louis flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Santiago-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Santiago-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Santiago to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Santiago with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated January 21, 2026.
Read through reviews of airlines operating flights from Santiago to St. Louis, such as Delta and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,088 reviews

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,088 reviews
Delta
7.9
Good
8,088 reviews

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,174 reviews
Delta
7.9
Good
8,088 reviews

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Entertainment

7.8

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Santiago to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Santiago to St. Louis?

    A quick flight from Santiago to St. Louis can take about 19h 45m. Delta provides one of the quickest options available for as low as $863. The distance between Santiago and St. Louis is about 5137 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines flying from Santiago to St. Louis round-trip?

    According to our current data, Delta ($877), and American Airlines ($948) offers the cheapest pricing from Santiago to St. Louis. You may be able to fly from Santiago to St. Louis for 11% less than the average price by searching for these airlines.

  • Can I find deals for flights from Santiago to St. Louis that include hotel bookings?

    Yes. In addition to deals on Santiago to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Santiago to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Santiago to St. Louis.

  • Can I find deals for business class flights from Santiago to St. Louis?

    Yes. Cheapflights offers flight deals from Santiago to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
Chesterfield
Alton
Farmington
Festus

Browse thousands of different options on Cheapflights for your next trip

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Top 2 airlines flying from Santiago to St. Louis

Discover the top 2 airlines that operate flights from Santiago to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$877Average$1,065FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$948Average$1,150FlexibilityNo cancel feeOn-time71%

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