$151+ Cheap flights from San Diego (SAN) to South America
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/21. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — BOG
Jun 10 — Jun 171
Round-trip
1 adult, Economy
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Find cheap flights from San Diego to South America with Cheapflights
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from San Diego to South AmericaExplore the most affordable flight options available from San Diego to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 11, 2026.
Explore the most affordable flight options available from San Diego to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 11, 2026.
This Copa Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/169:07 pm
SAN
- UIO
1 stop13h 23m
Copa Airlines
Wed 10/213:09 am
UIO
- SAN
1 stop17h 34m
Copa Airlines
Deal found 5/8![Copa Airlines logo]()
$381
This United Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:04 pm
SAN
- UIO
1 stop30h 21m
United Airlines
Wed 10/2112:35 am
UIO
- SAN
2 stops25h 54m
United Airlines
Deal found 5/6![United Airlines logo]()
$437
This Avianca deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/212:17 pm
SAN
- UIO
1 stop14h 18m
Multiple Airlines
Mon 9/285:25 pm
UIO
- SAN
1 stop17h 52m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$440
This Aviatur deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aviatur is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/279:37 pm
SAN
- MDE
1 stop33h 33m
Multiple Airlines
Tue 6/210:40 pm
MDE
- SAN
1 stop13h 55m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$448
This Copa Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1310:00 pm
SAN
- UIO
1 stop12h 32m
Copa Airlines
Sun 5/246:00 am
UIO
- SAN
1 stop14h 30m
Copa Airlines
Deal found 5/7![Copa Airlines logo]()
$449
This United Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/238:00 am
SAN
- UIO
1 stop13h 25m
United Airlines
Fri 8/287:25 am
UIO
- SAN
1 stop12h 21m
United Airlines
Deal found 5/8![United Airlines logo]()
$453
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:15 am
SAN
- UIO
1 stop15h 10m
United Airlines
Sun 5/247:25 am
UIO
- SAN
1 stop15h 59m
United Airlines
Deal found 5/9![United Airlines logo]()
$460
This Trip.com deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/317:00 am
SAN
- MDE
1 stop24h 10m
Multiple Airlines
Wed 6/34:55 pm
MDE
- SAN
1 stop29h 03m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$461
This United Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/53:00 pm
SAN
- UIO
1 stop30h 30m
United Airlines
Sat 11/71:35 am
UIO
- SAN
1 stop23h 18m
United Airlines
Deal found 5/10![United Airlines logo]()
$462
This United Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/191:24 pm
SAN
- UIO
2 stops32h 01m
United Airlines
Mon 8/247:25 am
UIO
- SAN
2 stops27h 40m
United Airlines
Deal found 5/8![United Airlines logo]()
$467
This Copa Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/268:58 pm
SAN
- MDE
1 stop11h 57m
Copa Airlines
Sun 8/309:15 am
MDE
- SAN
1 stop11h 15m
Copa Airlines
Deal found 5/8![Copa Airlines logo]()
$475
This Trip.com deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/242:17 pm
SAN
- MDE
1 stop19h 03m
Multiple Airlines
Tue 9/110:40 pm
MDE
- SAN
1 stop17h 45m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$482
Best flights from San Diego to South AmericaDiscover carefully curated flight deals from San Diego to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 11, 2026.
Discover carefully curated flight deals from San Diego to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 11, 2026.
This Copa Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/29:07 pm
SAN
- UIO
1 stop18h 23m
Copa Airlines
Fri 10/96:02 am
UIO
- SAN
1 stop14h 28m
Copa Airlines
Deal found 5/10![Copa Airlines logo]()
$381
This United Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/163:04 pm
SAN
- UIO
1 stop30h 21m
United Airlines
Wed 10/2112:35 am
UIO
- SAN
2 stops25h 54m
United Airlines
Deal found 5/6![United Airlines logo]()
$437
This Expedia deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/27:00 am
SAN
- UIO
1 stop21h 35m
Multiple Airlines
Fri 10/94:40 pm
UIO
- SAN
2 stops18h 37m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$493
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/77:56 pm
SAN
- LIM
1 stop24h 14m
Delta
Tue 6/1612:00 pm
LIM
- SAN
1 stop13h 40m
Delta
Deal found 5/6![Delta logo]()
$646
This Copa Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/248:58 pm
SAN
- UIO
1 stop15h 10m
Copa Airlines
Fri 8/286:00 am
UIO
- SAN
1 stop14h 30m
Copa Airlines
Deal found 5/8![Copa Airlines logo]()
$381
This KAYAK deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1410:54 am
SAN
- SCL
1 stop15h 41m
LATAM Airlines
Fri 8/2111:05 pm
SCL
- SAN
2 stops37h 31m
LATAM Airlines
Deal found 5/8![LATAM Airlines logo]()
$765
This American Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1812:37 pm
SAN
- SCL
1 stop15h 28m
American Airlines
Wed 6/249:00 pm
SCL
- SAN
1 stop28h 19m
American Airlines
Deal found 5/10![American Airlines logo]()
$825
This GOL deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure GOL is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/281:55 pm
SAN
- GRU
1 stop15h 05m
GOL
Wed 8/59:25 pm
GRU
- SAN
1 stop18h 07m
GOL
Deal found 5/6![GOL logo]()
$901
This United Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2810:13 am
SAN
- UIO
1 stop11h 12m
United Airlines
Tue 9/2912:35 am
UIO
- SAN
2 stops25h 54m
United Airlines
Deal found 5/5![United Airlines logo]()
$502
This Copa Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/268:58 pm
SAN
- MDE
1 stop11h 57m
Copa Airlines
Sun 8/309:15 am
MDE
- SAN
1 stop11h 15m
Copa Airlines
Deal found 5/8![Copa Airlines logo]()
$475
This United Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:30 pm
SAN
- UIO
2 stops27h 00m
United Airlines
Tue 11/101:35 am
UIO
- SAN
1 stop21h 22m
United Airlines
Deal found 5/10![United Airlines logo]()
$505
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:41 pm
SAN
- UIO
2 stops25h 44m
United Airlines
Mon 5/257:25 am
UIO
- SAN
1 stop14h 25m
United Airlines
Deal found 5/9![United Airlines logo]()
$509
This Copa Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/710:00 pm
SAN
- UIO
1 stop17h 27m
Copa Airlines
Fri 6/128:21 am
UIO
- SAN
1 stop12h 19m
Copa Airlines
Deal found 5/7![Copa Airlines logo]()
$543
This United Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:28 pm
SAN
- MDE
2 stops24h 42m
United Airlines
Sat 10/39:45 am
MDE
- SAN
2 stops25h 20m
United Airlines
Deal found 5/10![United Airlines logo]()
$512
This Delta deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1810:30 pm
SAN
- UIO
2 stops28h 13m
Delta
Sun 8/2312:59 am
UIO
- SAN
1 stop13h 34m
Delta
Deal found 5/8![Delta logo]()
$685
This United Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:41 pm
SAN
- MDE
2 stops23h 29m
United Airlines
Tue 9/19:45 am
MDE
- SAN
2 stops25h 20m
United Airlines
Deal found 5/10![United Airlines logo]()
$527
This Delta deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/1010:43 am
SAN
- LIM
2 stops16h 17m
Delta
Wed 6/2412:00 pm
LIM
- SAN
1 stop13h 40m
Delta
Deal found 5/10![Delta logo]()
$710
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/276:15 am
SAN
- LIM
1 stop13h 55m
Delta
Sun 8/212:50 am
LIM
- SAN
1 stop20h 28m
Delta
Deal found 5/6![Delta logo]()
$715
This oojo deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/149:27 pm
SAN
- SCL
2 stops29h 08m
Multiple Airlines
Fri 8/2111:25 pm
SCL
- SAN
2 stops22h 37m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$882
This United Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/16:28 pm
SAN
- MDE
2 stops24h 42m
United Airlines
Wed 10/79:45 am
MDE
- SAN
2 stops14h 57m
United Airlines
Deal found 5/7![United Airlines logo]()
$572
This Copa Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/119:03 pm
SAN
- LIM
1 stop16h 37m
Copa Airlines
Sat 9/192:35 am
LIM
- SAN
1 stop17h 55m
Copa Airlines
Deal found 5/6![Copa Airlines logo]()
$713
This Delta deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/126:15 am
SAN
- SCL
1 stop22h 00m
Delta
Sun 7/1910:55 pm
SCL
- SAN
1 stop24h 39m
Delta
Deal found 5/8![Delta logo]()
$772
This Copa Airlines deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/110:00 pm
SAN
- LIM
1 stop14h 40m
Copa Airlines
Fri 11/132:15 am
LIM
- SAN
1 stop18h 42m
Copa Airlines
Deal found 5/8![Copa Airlines logo]()
$713
This United Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/256:15 am
SAN
- MDE
1 stop12h 55m
United Airlines
Tue 7/79:45 am
MDE
- SAN
1 stop12h 05m
United Airlines
Deal found 5/6![United Airlines logo]()
$593
This Booking.com deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/157:00 am
SAN
- SDU
2 stops29h 45m
Multiple Airlines
Tue 9/226:00 am
SDU
- SAN
2 stops34h 16m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$973
This KAYAK deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2110:55 am
SAN
- SDU
2 stops17h 40m
LATAM Airlines
Tue 11/38:15 pm
SDU
- SAN
2 stops27h 40m
LATAM Airlines
Deal found 5/9![LATAM Airlines logo]()
$1,103
This Delta deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:30 pm
SAN
- GRU
2 stops20h 30m
Delta
Tue 10/138:30 pm
GRU
- SAN
1 stop19h 38m
Delta
Deal found 5/6![Delta logo]()
$778
This Copa Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/2210:00 pm
SAN
- LIM
1 stop19h 15m
Copa Airlines
Fri 7/34:00 am
LIM
- SAN
1 stop16h 30m
Copa Airlines
Deal found 5/9![Copa Airlines logo]()
$726
This United Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/215:15 pm
SAN
- MDE
1 stop25h 55m
United Airlines
Tue 5/269:45 am
MDE
- SAN
2 stops25h 20m
United Airlines
Deal found 5/10![United Airlines logo]()
$621
This GOL deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure GOL is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/2210:26 pm
SAN
- VCP
2 stops32h 19m
GOL
Wed 7/86:00 pm
VCP
- SAN
2 stops21h 12m
GOL
Deal found 5/8![GOL logo]()
$1,222
Last-minute flights from San Diego to South AmericaDiscover last-minute flight deals from San Diego to South America. Data last updated May 11, 2026 and is based on user searches.
Discover last-minute flight deals from San Diego to South America. Data last updated May 11, 2026 and is based on user searches.
This Travelocity deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/93:20 pm
SAN
- MDE
1 stop15h 50m
Multiple Airlines
Wed 5/202:10 pm
MDE
- SAN
2 stops26h 28m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$505
This Orbitz deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/119:10 pm
SAN
- MDE
2 stops17h 40m
Multiple Airlines
Thu 5/2110:40 pm
MDE
- SAN
1 stop23h 18m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$510
This Delta deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:15 am
SAN
- UIO
1 stop10h 44m
Delta
Mon 5/256:50 pm
UIO
- SAN
2 stops19h 48m
Delta
Deal found 5/5![Delta logo]()
$469
This KAYAK deal was found by Cheapflights users on 5/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/128:00 am
SAN
- UIO
2 stops18h 43m
LATAM Airlines
Mon 5/256:50 pm
UIO
- SAN
2 stops26h 33m
LATAM Airlines
Deal found 5/8![LATAM Airlines logo]()
$474
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/126:15 am
SAN
- UIO
1 stop15h 10m
United Airlines
Mon 5/257:25 am
UIO
- SAN
1 stop14h 25m
United Airlines
Deal found 5/9![United Airlines logo]()
$505
This Copa Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1310:00 pm
SAN
- UIO
1 stop12h 32m
Copa Airlines
Sun 5/246:00 am
UIO
- SAN
1 stop14h 30m
Copa Airlines
Deal found 5/7![Copa Airlines logo]()
$449
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:15 am
SAN
- UIO
1 stop15h 10m
United Airlines
Sun 5/247:25 am
UIO
- SAN
1 stop15h 59m
United Airlines
Deal found 5/9![United Airlines logo]()
$460
This Mytrip deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/1510:00 pm
SAN
- MDE
1 stop19h 55m
Copa Airlines
Fri 5/295:40 am
MDE
- SAN
1 stop14h 50m
Copa Airlines
Deal found 5/6![Copa Airlines logo]()
$495
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/227:41 pm
SAN
- UIO
2 stops25h 44m
United Airlines
Mon 5/257:25 am
UIO
- SAN
1 stop14h 25m
United Airlines
Deal found 5/9![United Airlines logo]()
$509
This Aviatur deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aviatur is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/279:37 pm
SAN
- MDE
1 stop33h 33m
Multiple Airlines
Tue 6/210:40 pm
MDE
- SAN
1 stop13h 55m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$448
This United Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/271:39 pm
SAN
- MDE
2 stops29h 31m
United Airlines
Tue 6/29:45 am
MDE
- SAN
1 stop12h 05m
United Airlines
Deal found 5/10![United Airlines logo]()
$512
This Trip.com deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/317:00 am
SAN
- MDE
1 stop24h 10m
Multiple Airlines
Wed 6/34:55 pm
MDE
- SAN
1 stop29h 03m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$461
One-way flights from San Diego to South AmericaSearch for one-way flight options from San Diego to South America. Find affordable one-way fares based on user searches. Data last updated May 11, 2026.
Search for one-way flight options from San Diego to South America. Find affordable one-way fares based on user searches. Data last updated May 11, 2026.
This Copa Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/218:58 pm
SAN
- UIO
1 stop13h 33m
Copa Airlines
Deal found 5/7![Copa Airlines logo]()
$151
This eDestinos deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/179:37 pm
SAN
- UIO
1 stop30h 58m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$196
This BusinessClass deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/33:40 pm
SAN
- UIO
2 stops25h 17m
GOL
Deal found 5/10![GOL logo]()
$204
This United Airlines deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/176:05 pm
SAN
- UIO
2 stops27h 20m
United Airlines
Deal found 5/10![United Airlines logo]()
$207
This eDestinos deal was found by Cheapflights users on 5/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/219:05 am
SAN
- UIO
2 stops15h 50m
Multiple Airlines
Deal found 5/10![Multiple Airlines logo]()
$210
This Copa Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/1610:00 pm
SAN
- UIO
1 stop14h 08m
Copa Airlines
Deal found 5/7![Copa Airlines logo]()
$222
This United Airlines deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2112:01 pm
SAN
- UIO
1 stop9h 24m
United Airlines
Deal found 5/9![United Airlines logo]()
$223
This FlightHub deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2811:45 am
SAN
- MDE
1 stop19h 25m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$227
This FlightHub deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/318:35 pm
SAN
- UIO
3 stops28h 20m
Multiple Airlines
Deal found 5/6![Multiple Airlines logo]()
$228
This Copa Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1710:00 pm
SAN
- MDE
1 stop8h 15m
Copa Airlines
Deal found 5/7![Copa Airlines logo]()
$246
This Travelocity deal was found by Cheapflights users on 5/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:00 am
SAN
- MDE
1 stop26h 20m
Multiple Airlines
Deal found 5/9![Multiple Airlines logo]()
$248
This United Airlines deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/287:41 pm
SAN
- MDE
2 stops23h 29m
United Airlines
Deal found 5/6![United Airlines logo]()
$249
Find flight deals from San Diego to South America
Keep the following information in mind while searching for San Diego to South America flight deals. Data was last updated May 11, 2026.
Round-trip from | $381 (Copa Airlines) |
|---|---|
One-way from | $151 (Copa Airlines) |
Popular in | March |
Cheapest in | August |
Average price | $614 |
Cheapflights Fare Finder
Customize your flight search to find flights from San Diego to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 11, 2026.
Use the filters below to find and compare flights from San Diego to South America that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San DiegoQuito
SAN - UIO
SANUIO
San Diego
Fri 10/2
9:07 pm-5:30 pm
1 stop18h 23m
Quito Mariscal Sucr
Fri 10/9
6:02 am-6:30 pm
1 stop14h 28m
$381
San DiegoQuito
SAN - UIO
SANUIO
San Diego
Mon 8/24
8:58 pm-2:08 pm
1 stop15h 10m
Quito Mariscal Sucr
Fri 8/28
6:00 am-6:30 pm
1 stop14h 30m
$381
San DiegoQuito
SAN - UIO
SANUIO
San Diego
Fri 10/16
3:04 pm-11:25 pm
1 stop30h 21m
Quito Mariscal Sucr
Wed 10/21
12:35 am-12:29 am
2 stops25h 54m
$437
Quickest round-trip
San DiegoMedellín
SAN - MDE
SANMDE
San Diego
Wed 8/26
8:58 pm-10:55 am
1 stop11h 57m
Medellín Jose Maria Cordova Intl
Sun 8/30
9:15 am-6:30 pm
1 stop11h 15m
$475
San DiegoQuito
SAN - UIO
SANUIO
San Diego
Fri 10/2
7:00 am-6:35 am
1 stop21h 35m
Quito Mariscal Sucr
Fri 10/9
4:40 pm-9:17 am
2 stops18h 37m
$493
San DiegoQuito
SAN - UIO
SANUIO
San Diego
Mon 9/28
10:13 am-11:25 pm
1 stop11h 12m
Quito Mariscal Sucr
Tue 9/29
12:35 am-12:29 am
2 stops25h 54m
$502
San DiegoQuito
SAN - UIO
SANUIO
San Diego
Sun 11/1
6:30 pm-12:30 am
2 stops27h 00m
Quito Mariscal Sucr
Tue 11/10
1:35 am-7:57 pm
1 stop21h 22m
$505
San DiegoQuito
SAN - UIO
SANUIO
San Diego
Fri 5/22
7:41 pm-11:25 pm
2 stops25h 44m
Quito Mariscal Sucr
Mon 5/25
7:25 am-7:50 pm
1 stop14h 25m
$509
San DiegoMedellín
SAN - MDE
SANMDE
San Diego
Fri 9/18
6:28 pm-9:10 pm
2 stops24h 42m
Medellín Jose Maria Cordova Intl
Sat 10/3
9:45 am-9:05 am
2 stops25h 20m
$512
San DiegoMedellín
SAN - MDE
SANMDE
San Diego
Mon 8/24
7:41 pm-9:10 pm
2 stops23h 29m
Medellín Jose Maria Cordova Intl
Tue 9/1
9:45 am-9:05 am
2 stops25h 20m
$527
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from San Diego to South America
Have a flexible travel schedule? Discover the best time to fly to South America from San Diego with our price prediction graph.
SAN-UIO
SAN-MDE
SAN-GRU
SAN-SCL
SAN-VCP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Diego to South America
SAN-0SA
SAN-UIO
SAN-MDE
SAN-GRU
SAN-SCL
How far ahead should I book a flight from San Diego to South America?
The best time to book flights from San Diego to South America is 7 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from San Diego to South America?
Currently, April is the cheapest month in which you can book a flight from San Diego to South America (average of $177). Flying from San Diego to South America in December is currently the most expensive (average of $1,644). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing South America
Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated May 11, 2026.
See what other customers who have flown with Delta,Copa Airlines, andLATAM Airlines from San Diego to South America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Food
7.2
Entertainment
7.8
Overall
7.9
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Crew
8.5
Food
7.2
Entertainment
7.8
Overall
7.9
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Crew
8.5
Food
7.2
Entertainment
7.8
Overall
7.9
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Crew
8.5
Food
7.2
Entertainment
7.8
Overall
7.9
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Crew
8.5
Food
7.2
Entertainment
7.8
Overall
7.9
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Crew
8.5
Food
7.2
Entertainment
7.8
Overall
7.9
Boarding
8.1
Comfort
7.8
Reviews
1 / 20
10.0
ExcellentAaron,Oct 2024
LAX - LHR
Related info for your journey
Find useful and relevant information for your journey from San Diego to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for San Diego to South America
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Complete your trip
Complete your trip to South America by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from San Diego to South America by cabin class
Find flights from San Diego to South America, based on your preferred cabin class, be it economy, premium economy, business, or first class.
San Diego and South America flights
Browse other San Diego and South America flight options. Last updated on May 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Fly to South America countries
Consider these flights traveling to countries located in South America.
San Diego to South America flights
Consider these flights traveling from San Diego to South America.
Top 7 airlines flying from San Diego to South America
Discover the top 7 airlines that operate flights from San Diego to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$253 | Average$891 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$305 | Average$594 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$335 | Average$742 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$430 | Average$882 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$452 | Average$858 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$620 | Average$783 | FlexibilityNo cancel fee | On-time67% | |
| Cheapest$695 | Average$978 | FlexibilityNo cancel fee | On-time74% |