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South America

$136+ Cheap flights from Missouri to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/23. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BOG
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Missouri to South America

Keep the following information in mind while searching for Missouri to South America flight deals. Data was last updated September 15, 2025.

Round-trip from

$322
(Kiwi.com)

One-way from

$136
(CheapOair)

Popular in

January

Cheapest in

February

Average price

$1,239
From Missouri to South America
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One-way flight from Missouri to South America
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Highest demand for flights based on searches. 0% potential increase in price ($9 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($27 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Missouri to South America

Cheapest flights from Missouri to South America
Explore the most affordable flight options available from Missouri to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/117:15 pmSTL - MDE
1 stop29h 06mSpirit Airlines
Wed 10/151:16 amMDE - STL
1 stop8h 46mSpirit Airlines
Deal found 9/12$322
This CheapOair deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2310:57 amSTL - MDE
1 stop13h 24mSpirit Airlines
Sat 10/251:16 amMDE - STL
1 stop8h 46mSpirit Airlines
Deal found 9/13$325
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/117:15 pmSTL - MDE
1 stop29h 06mMultiple Airlines
Thu 10/162:22 pmMDE - STL
2 stops20h 15mMultiple Airlines
Deal found 9/12$348
This Mytrip deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1210:57 amSTL - MDE
1 stop13h 24mSpirit Airlines
Fri 10/171:16 amMDE - STL
1 stop16h 54mSpirit Airlines
Deal found 9/13$349
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/910:57 amSTL - MDE
1 stop13h 24mSpirit Airlines
Fri 10/172:22 pmMDE - STL
1 stop27h 48mSpirit Airlines
Deal found 9/12$350
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/910:57 amSTL - MDE
1 stop13h 24mSpirit Airlines
Sat 10/181:16 amMDE - STL
1 stop8h 46mSpirit Airlines
Deal found 9/12$355
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1210:57 amSTL - MDE
1 stop13h 24mSpirit Airlines
Wed 10/151:16 amMDE - STL
1 stop8h 46mSpirit Airlines
Deal found 9/12$367
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1210:57 amSTL - MDE
1 stop13h 24mSpirit Airlines
Sat 10/181:16 amMDE - STL
1 stop8h 46mSpirit Airlines
Deal found 9/12$372
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/910:57 amSTL - MDE
1 stop13h 24mMultiple Airlines
Thu 10/162:22 pmMDE - STL
2 stops20h 15mMultiple Airlines
Deal found 9/12$376
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/117:15 pmSTL - MDE
1 stop29h 06mSpirit Airlines
Fri 10/171:16 amMDE - STL
1 stop16h 54mSpirit Airlines
Deal found 9/13$377
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1211:32 amSTL - MDE
2 stops12h 49mMultiple Airlines
Fri 10/172:22 pmMDE - STL
1 stop27h 48mMultiple Airlines
Deal found 9/12$378
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/154:00 pmSTL - MDE
2 stops21h 14mMultiple Airlines
Fri 10/172:22 pmMDE - STL
1 stop27h 48mMultiple Airlines
Deal found 9/13$381

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Missouri to South America that are best for you.

Fly from

Missouri

Fly to

South America

Route

Depart

Return

Price

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Wed 11/5

10:09 am-1:55 pm

1 stop26h 46m

Medellín Jose Maria Cordova Intl

Sun 11/16

6:59 pm-11:08 am

1 stop17h 09m

$422

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Wed 10/29

8:40 pm-9:00 am

2 stops36h 20m

Medellín Jose Maria Cordova Intl

Wed 11/5

6:59 pm-11:01 am

1 stop17h 02m

$441

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Thu 10/9

5:15 am-12:21 am

2 stops19h 06m

Medellín Jose Maria Cordova Intl

Sat 10/11

1:16 am-9:59 pm

2 stops20h 43m

$483

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Tue 3/3

5:19 am-1:35 pm

1 stop7h 16m

Medellín Jose Maria Cordova Intl

Tue 3/10

12:20 am-3:42 pm

1 stop15h 22m

$566

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Tue 3/3

7:00 am-10:05 pm

2 stops14h 05m

Medellín Jose Maria Cordova Intl

Wed 3/11

9:45 am-10:06 pm

1 stop12h 21m

$566

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Wed 10/22

5:23 am-8:15 pm

1 stop14h 52m

Medellín Jose Maria Cordova Intl

Mon 11/3

7:00 am-10:27 pm

1 stop16h 27m

$590

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Wed 10/29

7:16 am-8:15 pm

2 stops12h 59m

Medellín Jose Maria Cordova Intl

Wed 11/5

7:00 am-7:30 pm

2 stops13h 30m

$594

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Sun 12/7

5:05 am-11:39 pm

1 stop17h 34m

Medellín Jose Maria Cordova Intl

Sun 12/14

1:30 am-11:27 am

1 stop10h 57m

$600

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Wed 11/5

6:00 am-10:05 pm

2 stops15h 05m

Medellín Jose Maria Cordova Intl

Sun 11/16

10:45 am-8:56 am

2 stops23h 11m

$604

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Wed 11/5

5:04 am-11:39 pm

1 stop17h 35m

Medellín Jose Maria Cordova Intl

Sat 11/15

1:30 am-2:01 pm

2 stops13h 31m

$604

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 51 results
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Best time to book a flight from Missouri to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to South America

What is the cheapest month to book a flight from Missouri to South America?

Currently, May is the cheapest month in which you can book a flight from Missouri to South America (average of $359). Flying from Missouri to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SA?

Find hourly flight availability from Missouri to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

When flying from Missouri to South America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Related info for your journey

Find useful and relevant information for your journey from Missouri to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to South America?

    For as low as $566, Spirit Airlines can have you in South America from Missouri in 7h 16m. Airlines will cover a distance of 2436 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Missouri to South America one-way?

    $136 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on American Airlines and Delta, with prices starting from $386 and $513, respectively.

  • Can I find deals for flights from Missouri to South America that include hotel bookings?

    Yes. In addition to deals on Missouri to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South America.

  • Can I find deals for business class flights from Missouri to South America?

    Yes. Cheapflights offers flight deals from Missouri to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to South America?

    Currently, May is the cheapest month in which you can book a flight from Missouri to South America (average of $359). Flying from Missouri to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Missouri to South America

Discover the top 6 airlines that operate flights from Missouri to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$307Average$438FlexibilityNo cancel feeOn-time65%
United AirlinesCheapest$401Average$962FlexibilityNo cancel feeOn-time69%
DeltaCheapest$413Average$925FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$452Average$927FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$535Average$898FlexibilityNo cancel feeOn-time81%
Air CanadaCheapest$758Average$766FlexibilityNo cancel feeOn-time67%

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