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$118+ Cheap flights from Missouri to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/23. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BOG
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Missouri to South America

Cheapest flights from Missouri to South America
Explore the most affordable flight options available from Missouri to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This CheapOair deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1711:26 am
MCI
-
MDE
1 stop12h 55m
Spirit Airlines
Tue 3/242:17 pm
MDE
-
MCI
1 stop20h 06m
Spirit Airlines
Deal found 1/27$272
This KAYAK deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1812:12 pm
MCI
-
MDE
1 stop25h 01m
Spirit Airlines
Fri 4/241:37 am
MDE
-
MCI
1 stop9h 30m
Spirit Airlines
Deal found 1/25$285
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1912:12 pm
MCI
-
MDE
1 stop12h 30m
Spirit Airlines
Wed 4/292:10 pm
MDE
-
MCI
1 stop20h 57m
Spirit Airlines
Deal found 1/25$289
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/111:26 am
MCI
-
MDE
1 stop25h 47m
Spirit Airlines
Thu 3/53:15 pm
MDE
-
MCI
1 stop20h 15m
Spirit Airlines
Deal found 1/27$295
This Travelocity deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/2012:12 pm
MCI
-
MDE
1 stop12h 30m
Spirit Airlines
Sat 4/251:37 am
MDE
-
MCI
1 stop9h 30m
Spirit Airlines
Deal found 1/25$301
This Priceline deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1812:12 pm
MCI
-
MDE
1 stop12h 30m
Spirit Airlines
Sun 4/261:37 am
MDE
-
MCI
1 stop9h 30m
Spirit Airlines
Deal found 1/26$306
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2312:12 pm
MCI
-
MDE
1 stop12h 30m
Spirit Airlines
Wed 4/292:10 pm
MDE
-
MCI
1 stop20h 57m
Spirit Airlines
Deal found 1/25$310
This Expedia deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2711:26 am
MCI
-
LIM
1 stop10h 09m
Spirit Airlines
Wed 3/411:30 pm
LIM
-
MCI
1 stop12h 00m
Spirit Airlines
Deal found 1/27$453
This FlightHub deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/711:26 am
MCI
-
LIM
1 stop10h 04m
Spirit Airlines
Sun 4/1910:30 pm
LIM
-
MCI
1 stop12h 37m
Spirit Airlines
Deal found 1/25$472
This Travelocity deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2011:26 am
MCI
-
LIM
1 stop10h 04m
Spirit Airlines
Mon 3/3010:30 pm
LIM
-
MCI
1 stop11h 53m
Spirit Airlines
Deal found 1/27$516
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/412:12 pm
MCI
-
LIM
1 stop33h 23m
Spirit Airlines
Fri 5/810:30 pm
LIM
-
MCI
1 stop12h 37m
Spirit Airlines
Deal found 1/27$536
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:00 am
STL
-
CTG
1 stop7h 20m
Delta
Tue 4/212:35 pm
CTG
-
STL
1 stop8h 59m
Delta
Deal found 1/27$543

Find flight deals from Missouri to South America

Keep the following information in mind while searching for Missouri to South America flight deals. Data was last updated January 28, 2026.

Round-trip from

$272
(CheapOair)

One-way from

$118
(Priceline)

Popular in

December

Cheapest in

April

Average price

$655
From Missouri to South America
Search Deals
One-way flight from Missouri to South America
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($74 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($22 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Missouri to South America that are best for you.

Fly from

Missouri

Fly to

South America

Route

Depart

Return

Price

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Mon 4/20

12:12 pm-12:42 am

1 stop12h 30m

Medellín Jose Maria Cordova Intl

Wed 4/29

1:37 am-11:07 am

1 stop9h 30m

$289

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Fri 4/17

12:12 pm-12:42 am

1 stop12h 30m

Medellín Jose Maria Cordova Intl

Fri 4/24

1:37 am-11:07 am

1 stop9h 30m

$332

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Thu 4/23

12:12 pm-12:42 am

1 stop12h 30m

Medellín Jose Maria Cordova Intl

Fri 5/1

4:53 am-11:07 am

2 stops30h 14m

$387

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Tue 4/21

6:00 am-12:42 am

2 stops18h 42m

Medellín Jose Maria Cordova Intl

Thu 4/23

1:37 am-11:07 am

1 stop9h 30m

$409

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Thu 4/30

12:12 pm-12:42 am

1 stop12h 30m

Medellín Jose Maria Cordova Intl

Tue 5/5

10:52 am-11:59 pm

1 stop13h 07m

$485

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Wed 4/22

6:00 am-12:42 am

2 stops18h 42m

Medellín Jose Maria Cordova Intl

Wed 4/29

1:37 am-11:07 am

1 stop9h 30m

$490

Kansas CityLima

MCI - LIM

MCILIM

Kansas City

Tue 4/7

5:45 am-9:30 pm

2 stops15h 45m

Lima J Chavez Intl

Sun 4/19

10:30 pm-11:07 am

1 stop12h 37m

$523

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Thu 4/30

6:00 am-10:56 pm

2 stops16h 56m

Medellín Jose Maria Cordova Intl

Tue 5/5

6:13 am-11:59 pm

2 stops17h 46m

$542

St. LouisCartagena

STL - CTG

STLCTG

Lambert-St Louis

Tue 4/14

6:00 am-1:20 pm

1 stop7h 20m

Cartagena Rafael Nunez

Tue 4/21

2:35 pm-11:34 pm

1 stop8h 59m

$543

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Mon 4/20

6:00 am-11:42 pm

2 stops17h 42m

Medellín Jose Maria Cordova Intl

Tue 4/28

5:53 am-11:59 pm

2 stops18h 06m

$543

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/26

Showing 1-10 of 58 results
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Best time to book a flight from Missouri to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to South America

What is the cheapest month to book a flight from Missouri to South America?

Currently, October is the cheapest month in which you can book a flight from Missouri to South America (average of $303). Flying from Missouri to South America in November is currently the most expensive (average of $541). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to South America?

    For as low as $543, Spirit Airlines can have you in South America from Missouri in 7h 20m. Airlines will cover a distance of 2159 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Missouri to South America one-way?

    $109 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on American Airlines and LATAM Airlines, with prices starting from $289 and $321, respectively.

  • Can I find deals for flights from Missouri to South America that include hotel bookings?

    Yes. In addition to deals on Missouri to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South America.

  • Can I find deals for business class flights from Missouri to South America?

    Yes. Cheapflights offers flight deals from Missouri to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to South America?

    Currently, October is the cheapest month in which you can book a flight from Missouri to South America (average of $303). Flying from Missouri to South America in November is currently the most expensive (average of $541). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Missouri to South America

Discover the top 6 airlines that operate flights from Missouri to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$303Average$392FlexibilityNo cancel feeOn-time65%
LATAM AirlinesCheapest$351Average$922FlexibilityNo cancel feeOn-time81%
DeltaCheapest$444Average$956FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$452Average$869FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$462Average$906FlexibilityNo cancel feeOn-time69%
Air CanadaCheapest$758Average$767FlexibilityNo cancel feeOn-time67%

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