$179+ Cheap flights from Missouri to South America
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/10. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BOG
Apr 15 — Apr 221
Round-trip
1 adult, Economy
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Find cheap flights from Missouri to South America with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to South America
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Cheapest flights from Missouri to South AmericaExplore the most affordable flight options available from Missouri to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 16, 2026.
Explore the most affordable flight options available from Missouri to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 16, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2812:24 pm
MCI
- BOG
1 stop24h 47m
Spirit Airlines
Tue 4/72:10 pm
BOG
- MCI
1 stop21h 19m
Spirit Airlines
Deal found 3/14![Spirit Airlines logo]()
$406
This eDestinos deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2912:24 pm
MCI
- MDE
1 stop11h 57m
Spirit Airlines
Wed 4/11:52 pm
MDE
- MCI
1 stop10h 01m
Spirit Airlines
Deal found 3/15![Spirit Airlines logo]()
$413
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2812:24 pm
MCI
- BOG
1 stop24h 47m
Spirit Airlines
Wed 4/82:10 pm
BOG
- MCI
1 stop21h 19m
Spirit Airlines
Deal found 3/13![Spirit Airlines logo]()
$433
This KAYAK deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:45 am
MCI
- MDE
1 stop28h 06m
Spirit Airlines
Sat 4/111:52 pm
MDE
- MCI
1 stop10h 01m
Spirit Airlines
Deal found 3/15![Spirit Airlines logo]()
$444
This CheapOair deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/95:45 am
MCI
- MDE
1 stop7h 07m
Spirit Airlines
Thu 4/301:55 pm
MDE
- MCI
1 stop27h 11m
Spirit Airlines
Deal found 3/15![Spirit Airlines logo]()
$447
This CheapOair deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/212:24 pm
MCI
- BOG
1 stop24h 47m
Spirit Airlines
Mon 4/62:10 pm
BOG
- MCI
1 stop21h 19m
Spirit Airlines
Deal found 3/11![Spirit Airlines logo]()
$456
This KAYAK deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/65:45 am
MCI
- MDE
1 stop28h 06m
Spirit Airlines
Sat 4/111:52 pm
MDE
- MCI
1 stop10h 01m
Spirit Airlines
Deal found 3/15![Spirit Airlines logo]()
$461
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/3012:24 pm
MCI
- BOG
2 stops22h 16m
Multiple Airlines
Tue 4/72:10 pm
BOG
- MCI
1 stop21h 19m
Multiple Airlines
Deal found 3/13![Multiple Airlines logo]()
$464
This CheapOair deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/25:45 am
MCI
- MDE
1 stop7h 07m
Spirit Airlines
Thu 4/231:55 pm
MDE
- MCI
1 stop27h 11m
Spirit Airlines
Deal found 3/15![Spirit Airlines logo]()
$470
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2812:24 pm
MCI
- BOG
2 stops17h 11m
Multiple Airlines
Tue 4/72:10 pm
BOG
- MCI
1 stop21h 19m
Multiple Airlines
Deal found 3/13![Multiple Airlines logo]()
$472
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2912:24 pm
MCI
- BOG
2 stops13h 56m
Multiple Airlines
Tue 4/72:10 pm
BOG
- MCI
1 stop21h 19m
Multiple Airlines
Deal found 3/13![Multiple Airlines logo]()
$476
This CheapOair deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2912:24 pm
MCI
- BOG
1 stop24h 47m
Spirit Airlines
Wed 4/112:50 pm
BOG
- MCI
1 stop11h 03m
Spirit Airlines
Deal found 3/15![Spirit Airlines logo]()
$477
Best flights from Missouri to South AmericaDiscover carefully curated flight deals from Missouri to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 16, 2026.
Discover carefully curated flight deals from Missouri to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 16, 2026.
This CheapOair deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/186:01 pm
MCI
- MDE
1 stop18h 59m
Spirit Airlines
Sat 5/161:55 pm
MDE
- MCI
1 stop27h 28m
Spirit Airlines
Deal found 3/13![Spirit Airlines logo]()
$504
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/96:29 pm
STL
- MDE
2 stops18h 23m
Multiple Airlines
Sun 4/1210:49 am
MDE
- STL
1 stop21h 02m
Multiple Airlines
Deal found 3/14![Multiple Airlines logo]()
$509
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/283:24 pm
STL
- CTG
2 stops20h 45m
American Airlines
Tue 5/51:25 pm
CTG
- STL
2 stops19h 05m
American Airlines
Deal found 3/13![American Airlines logo]()
$590
This Delta deal was found by Cheapflights users on 3/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:00 am
STL
- CTG
1 stop7h 20m
Delta
Tue 4/212:35 pm
CTG
- STL
1 stop9h 01m
Delta
Deal found 3/16![Delta logo]()
$606
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/128:00 am
MCI
- MDE
2 stops13h 10m
United Airlines
Tue 5/199:45 am
MDE
- MCI
1 stop12h 44m
United Airlines
Deal found 3/12![United Airlines logo]()
$629
This Gurufare deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gurufare is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/2412:04 pm
MCI
- BOG
2 stops28h 26m
LATAM Airlines
Tue 8/42:55 pm
BOG
- MCI
1 stop9h 00m
LATAM Airlines
Deal found 3/12![LATAM Airlines logo]()
$646
This Copa Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/299:58 am
MCI
- LIM
2 stops15h 22m
Copa Airlines
Wed 5/611:00 am
LIM
- MCI
2 stops21h 41m
Copa Airlines
Deal found 3/11![Copa Airlines logo]()
$718
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:59 pm
STL
- MDE
1 stop20h 01m
Multiple Airlines
Mon 4/271:55 pm
MDE
- STL
1 stop9h 24m
Multiple Airlines
Deal found 3/11![Multiple Airlines logo]()
$524
This Kiwi.com deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/1312:24 pm
MCI
- BOG
1 stop24h 47m
Multiple Airlines
Mon 4/209:30 pm
BOG
- MCI
2 stops43h 36m
Multiple Airlines
Deal found 3/15![Multiple Airlines logo]()
$527
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/125:24 am
STL
- CTG
1 stop6h 45m
American Airlines
Sun 5/171:25 pm
CTG
- STL
1 stop8h 59m
American Airlines
Deal found 3/11![American Airlines logo]()
$607
This Delta deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:00 am
MCI
- BOG
2 stops13h 10m
Delta
Tue 9/158:40 am
BOG
- MCI
2 stops13h 42m
Delta
Deal found 3/15![Delta logo]()
$624
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:15 am
MCI
- MDE
1 stop14h 55m
United Airlines
Thu 5/219:45 am
MDE
- MCI
2 stops23h 22m
United Airlines
Deal found 3/12![United Airlines logo]()
$629
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/264:59 pm
STL
- MDE
1 stop20h 01m
Multiple Airlines
Sun 5/31:55 pm
MDE
- STL
1 stop9h 24m
Multiple Airlines
Deal found 3/11![Multiple Airlines logo]()
$533
This American Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/116:53 pm
STL
- CTG
2 stops19h 11m
American Airlines
Sat 4/183:10 pm
CTG
- STL
2 stops21h 38m
American Airlines
Deal found 3/12![American Airlines logo]()
$611
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/146:15 am
MCI
- MDE
1 stop14h 55m
United Airlines
Fri 5/229:45 am
MDE
- MCI
1 stop12h 46m
United Airlines
Deal found 3/12![United Airlines logo]()
$634
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/96:42 pm
MCI
- BOG
2 stops23h 08m
Delta
Sun 8/168:40 am
BOG
- MCI
2 stops15h 12m
Delta
Deal found 3/14![Delta logo]()
$634
This Copa Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/237:53 am
MCI
- LIM
2 stops17h 27m
Copa Airlines
Mon 8/102:15 am
LIM
- MCI
2 stops19h 25m
Copa Airlines
Deal found 3/11![Copa Airlines logo]()
$718
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/24:54 pm
STL
- MDE
1 stop16h 57m
Multiple Airlines
Sun 4/510:49 am
MDE
- STL
1 stop21h 02m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$543
This American Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/65:00 am
MCI
- CTG
1 stop7h 09m
American Airlines
Mon 5/113:10 pm
CTG
- MCI
2 stops19h 05m
American Airlines
Deal found 3/14![American Airlines logo]()
$615
This Delta deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:00 am
STL
- CTG
2 stops13h 35m
Delta
Tue 4/285:30 am
CTG
- STL
2 stops15h 49m
Delta
Deal found 3/14![Delta logo]()
$635
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/96:15 am
MCI
- MDE
1 stop14h 55m
United Airlines
Mon 5/189:45 am
MDE
- MCI
1 stop28h 16m
United Airlines
Deal found 3/12![United Airlines logo]()
$644
This Copa Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/248:20 pm
MCI
- LIM
2 stops16h 05m
Copa Airlines
Thu 8/202:35 am
LIM
- MCI
2 stops19h 05m
Copa Airlines
Deal found 3/14![Copa Airlines logo]()
$766
This Delta deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/186:38 pm
MCI
- BOG
1 stop19h 02m
Delta
Fri 6/511:00 am
BOG
- MCI
2 stops24h 16m
Delta
Deal found 3/15![Delta logo]()
$639
This United Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/118:30 am
MCI
- MDE
1 stop12h 40m
United Airlines
Mon 8/249:45 am
MDE
- MCI
1 stop12h 48m
United Airlines
Deal found 3/14![United Airlines logo]()
$644
This American Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/255:30 am
MCI
- BOG
1 stop17h 00m
American Airlines
Tue 8/412:25 pm
BOG
- MCI
2 stops11h 59m
American Airlines
Deal found 3/11![American Airlines logo]()
$644
This Mytrip deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/212:24 pm
MCI
- BOG
3 stops23h 46m
Multiple Airlines
Mon 4/64:45 am
BOG
- MCI
3 stops30h 44m
Multiple Airlines
Deal found 3/11![Multiple Airlines logo]()
$629
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/216:30 am
MCI
- BOG
1 stop12h 50m
United Airlines
Tue 5/512:14 am
BOG
- MCI
1 stop16h 28m
United Airlines
Deal found 3/11![United Airlines logo]()
$647
This American Airlines deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/211:48 am
STL
- MDE
1 stop8h 27m
American Airlines
Sun 9/612:25 am
MDE
- STL
1 stop10h 33m
American Airlines
Deal found 3/13![American Airlines logo]()
$649
This LATAM Airlines deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/299:59 am
STL
- SCL
2 stops19h 01m
LATAM Airlines
Wed 5/65:40 am
SCL
- STL
2 stops18h 56m
LATAM Airlines
Deal found 3/14![LATAM Airlines logo]()
$958
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/206:30 am
MCI
- BOG
1 stop12h 50m
United Airlines
Thu 5/78:30 am
BOG
- MCI
1 stop13h 59m
United Airlines
Deal found 3/11![United Airlines logo]()
$647
Last-minute flights from Missouri to South AmericaDiscover last-minute flight deals from Missouri to South America. Data last updated March 16, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to South America. Data last updated March 16, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2812:24 pm
MCI
- BOG
1 stop24h 47m
Spirit Airlines
Tue 4/72:10 pm
BOG
- MCI
1 stop21h 19m
Spirit Airlines
Deal found 3/14![Spirit Airlines logo]()
$406
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2812:24 pm
MCI
- BOG
1 stop24h 47m
Spirit Airlines
Wed 4/82:10 pm
BOG
- MCI
1 stop21h 19m
Spirit Airlines
Deal found 3/13![Spirit Airlines logo]()
$433
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/2812:24 pm
MCI
- BOG
2 stops17h 11m
Multiple Airlines
Tue 4/72:10 pm
BOG
- MCI
1 stop21h 19m
Multiple Airlines
Deal found 3/13![Multiple Airlines logo]()
$472
This eDestinos deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2912:24 pm
MCI
- MDE
1 stop11h 57m
Spirit Airlines
Wed 4/11:52 pm
MDE
- MCI
1 stop10h 01m
Spirit Airlines
Deal found 3/15![Spirit Airlines logo]()
$413
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2912:24 pm
MCI
- BOG
2 stops13h 56m
Multiple Airlines
Tue 4/72:10 pm
BOG
- MCI
1 stop21h 19m
Multiple Airlines
Deal found 3/13![Multiple Airlines logo]()
$476
This CheapOair deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/2912:24 pm
MCI
- BOG
1 stop24h 47m
Spirit Airlines
Wed 4/112:50 pm
BOG
- MCI
1 stop11h 03m
Spirit Airlines
Deal found 3/15![Spirit Airlines logo]()
$477
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/3012:24 pm
MCI
- BOG
2 stops22h 16m
Multiple Airlines
Tue 4/72:10 pm
BOG
- MCI
1 stop21h 19m
Multiple Airlines
Deal found 3/13![Multiple Airlines logo]()
$464
This CheapOair deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/212:24 pm
MCI
- BOG
1 stop24h 47m
Spirit Airlines
Mon 4/62:10 pm
BOG
- MCI
1 stop21h 19m
Spirit Airlines
Deal found 3/11![Spirit Airlines logo]()
$456
This CheapOair deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/25:45 am
MCI
- MDE
1 stop7h 07m
Spirit Airlines
Thu 4/231:55 pm
MDE
- MCI
1 stop27h 11m
Spirit Airlines
Deal found 3/15![Spirit Airlines logo]()
$470
This KAYAK deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/65:45 am
MCI
- MDE
1 stop28h 06m
Spirit Airlines
Sat 4/111:52 pm
MDE
- MCI
1 stop10h 01m
Spirit Airlines
Deal found 3/15![Spirit Airlines logo]()
$461
This KAYAK deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:45 am
MCI
- MDE
1 stop28h 06m
Spirit Airlines
Sat 4/111:52 pm
MDE
- MCI
1 stop10h 01m
Spirit Airlines
Deal found 3/15![Spirit Airlines logo]()
$444
This CheapOair deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/95:45 am
MCI
- MDE
1 stop7h 07m
Spirit Airlines
Thu 4/231:55 pm
MDE
- MCI
1 stop27h 11m
Spirit Airlines
Deal found 3/15![Spirit Airlines logo]()
$447
One-way flights from Missouri to South AmericaSearch for one-way flight options from Missouri to South America. Find affordable one-way fares based on user searches. Data last updated March 16, 2026.
Search for one-way flight options from Missouri to South America. Find affordable one-way fares based on user searches. Data last updated March 16, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1012:24 pm
MCI
- BOG
1 stop24h 47m
Spirit Airlines
Deal found 3/14![Spirit Airlines logo]()
$179
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1112:24 pm
MCI
- BOG
2 stops46h 01m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$193
This CheapOair deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/1112:24 pm
MCI
- BOG
1 stop24h 47m
Spirit Airlines
Deal found 3/12![Spirit Airlines logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/212:24 pm
MCI
- CTG
1 stop23h 42m
Spirit Airlines
Deal found 3/12![Spirit Airlines logo]()
$208
This CheapOair deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/225:45 am
MCI
- MDE
1 stop7h 07m
Spirit Airlines
Deal found 3/15![Spirit Airlines logo]()
$216
This Mytrip deal was found by Cheapflights users on 3/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1012:24 pm
MCI
- BOG
3 stops21h 01m
Multiple Airlines
Deal found 3/14![Multiple Airlines logo]()
$222
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/612:24 pm
MCI
- BOG
2 stops41h 24m
Multiple Airlines
Deal found 3/11![Multiple Airlines logo]()
$224
This CheapOair deal was found by Cheapflights users on 3/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/266:01 pm
MCI
- MDE
1 stop18h 59m
Spirit Airlines
Deal found 3/15![Spirit Airlines logo]()
$233
This Mytrip deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/212:24 pm
MCI
- CTG
2 stops21h 35m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$244
This Kiwi.com deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2311:53 am
MCI
- BOG
2 stops25h 19m
Multiple Airlines
Deal found 3/13![Multiple Airlines logo]()
$244
This CheapOair deal was found by Cheapflights users on 3/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/226:01 pm
MCI
- BOG
2 stops19h 11m
Spirit Airlines
Deal found 3/13![Spirit Airlines logo]()
$245
This Priceline deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/156:01 pm
MCI
- CTG
2 stops18h 05m
Spirit Airlines
Deal found 3/11![Spirit Airlines logo]()
$246
Find flight deals from Missouri to South America
Keep the following information in mind while searching for Missouri to South America flight deals. Data was last updated March 16, 2026.
Round-trip from | $406 (Kiwi.com) |
|---|---|
One-way from | $179 (Kiwi.com) |
Popular in | December |
Cheapest in | September |
Average price | $733 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
Use the filters below to find and compare flights from Missouri to South America that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Kansas CityMedellín
MCI - MDE
MCIMDE
Kansas City
Sat 4/18
6:01 pm-1:00 pm
1 stop18h 59m
Medellín Jose Maria Cordova Intl
Sat 5/16
1:55 pm-5:23 pm
1 stop27h 28m
$504
St. LouisMedellín
STL - MDE
STLMDE
Lambert-St Louis
Thu 4/9
6:29 pm-12:52 pm
2 stops18h 23m
Medellín Jose Maria Cordova Intl
Sun 4/12
10:49 am-7:51 am
1 stop21h 02m
$509
St. LouisMedellín
STL - MDE
STLMDE
Lambert-St Louis
Fri 4/24
4:59 pm-1:00 pm
1 stop20h 01m
Medellín Jose Maria Cordova Intl
Mon 4/27
1:55 pm-11:19 pm
1 stop9h 24m
$524
Kansas CityBogotá
MCI - BOG
MCIBOG
Kansas City
Mon 4/13
12:24 pm-1:11 pm
1 stop24h 47m
Bogotá El Dorado
Mon 4/20
9:30 pm-5:06 pm
2 stops43h 36m
$527
St. LouisMedellín
STL - MDE
STLMDE
Lambert-St Louis
Sun 4/26
4:59 pm-1:00 pm
1 stop20h 01m
Medellín Jose Maria Cordova Intl
Sun 5/3
1:55 pm-11:19 pm
1 stop9h 24m
$533
St. LouisMedellín
STL - MDE
STLMDE
Lambert-St Louis
Thu 4/2
4:54 pm-9:51 am
1 stop16h 57m
Medellín Jose Maria Cordova Intl
Sun 4/5
10:49 am-7:51 am
1 stop21h 02m
$543
St. LouisCartagena
STL - CTG
STLCTG
Lambert-St Louis
Tue 4/28
3:24 pm-12:09 pm
2 stops20h 45m
Cartagena Rafael Nunez
Tue 5/5
1:25 pm-8:30 am
2 stops19h 05m
$590
St. LouisCartagena
STL - CTG
STLCTG
Lambert-St Louis
Tue 4/14
6:00 am-1:20 pm
1 stop7h 20m
Cartagena Rafael Nunez
Tue 4/21
2:35 pm-11:36 pm
1 stop9h 01m
$606
Quickest round-trip
St. LouisCartagena
STL - CTG
STLCTG
Lambert-St Louis
Tue 5/12
5:24 am-12:09 pm
1 stop6h 45m
Cartagena Rafael Nunez
Sun 5/17
1:25 pm-10:24 pm
1 stop8h 59m
$607
St. LouisCartagena
STL - CTG
STLCTG
Lambert-St Louis
Sat 4/11
6:53 pm-2:04 pm
2 stops19h 11m
Cartagena Rafael Nunez
Sat 4/18
3:10 pm-12:48 pm
2 stops21h 38m
$611
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to South America
Have a flexible travel schedule? Discover the best time to fly to South America from Missouri with our price prediction graph.
MCI-BOG
MCI-MDE
STL-MDE
STL-CTG
MCI-LIM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to South America
USMO-0SA
MCI-BOG
MCI-MDE
STL-MDE
STL-CTG
What is the cheapest month to book a flight from Missouri to South America?
Currently, October is the cheapest month in which you can book a flight from Missouri to South America (average of $303). Flying from Missouri to South America in November is currently the most expensive (average of $541). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Missouri to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Top destinations
Alternative routes for Missouri to South America
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South America by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to South America by cabin class
Find flights from Missouri to South America, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and South America flights
Browse other Missouri and South America flight options. Last updated on March 16, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South America
Find the right flight back to Missouri after your stay in South America
Fly to South America countries
Consider these flights traveling to countries located in South America.
Missouri to South America flights
Consider these flights traveling from Missouri to South America.
Top 6 airlines flying from Missouri to South America
Discover the top 6 airlines that operate flights from Missouri to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$303 | Average$368 | FlexibilityNo cancel fee | On-time65% | |
| Cheapest$351 | Average$949 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$463 | Average$933 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$474 | Average$833 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$474 | Average$860 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$758 | Average$767 | FlexibilityNo cancel fee | On-time67% |