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South America

$130+ Cheap flights from Missouri to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/21. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BOG
ago. 4 — ago. 111
lun. 8/4
lun. 8/11
1 adult, Economy
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Cheap flight deals from Missouri to South America

Keep the following information in mind while searching for Missouri to South America flight deals. Data was last updated julio 30, 2025.

Round-trip from

$296
(FlightHub)

One-way from

$135
(FlightHub)

Popular in

June

Cheapest in

February

Average price

$1,225
From Missouri to South America
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One-way flight from Missouri to South America
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Highest demand for flights based on searches. 9% potential increase in price ($125 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($28 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Find flight deals from Missouri to South America

Cheapest flights from Missouri to South America
Explore the most affordable flight options available from Missouri to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on julio 30, 2025.

This FlightHub deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/2110:35 amSTL - MDE
1 stop13h 50mSpirit Airlines
mié. 10/292:09 pmMDE - STL
1 stop19h 31mSpirit Airlines
Deal found 7/28$296
This FlightHub deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/1211:23 amMCI - MDE
1 stop13h 02mSpirit Airlines
dom. 9/142:00 pmMDE - MCI
1 stop9h 07mSpirit Airlines
Deal found 7/29$331
This FlightHub deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/55:15 amMCI - BOG
1 stop30h 45mSpirit Airlines
lun. 9/812:55 pmBOG - MCI
1 stop10h 12mSpirit Airlines
Deal found 7/28$336
This Mytrip deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/2611:23 amMCI - BOG
3 stops21h 16mMultiple Airlines
lun. 9/2912:55 pmBOG - MCI
1 stop10h 12mMultiple Airlines
Deal found 7/29$372
This Avianca Connect deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/2110:37 amSTL - MDE
1 stop8h 13mMultiple Airlines
sáb. 8/2310:20 amMDE - STL
1 stop23h 20mMultiple Airlines
Deal found 7/30$392
This Kiwi.com deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/36:00 amMCI - MDE
1 stop31h 00mMultiple Airlines
dom. 9/77:09 amMDE - MCI
2 stops27h 19mMultiple Airlines
Deal found 7/29$431
This Trip.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/36:00 amMCI - GRU
2 stops31h 20mMultiple Airlines
sáb. 9/61:45 amGRU - MCI
2 stops23h 22mMultiple Airlines
Deal found 7/30$584
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/2510:35 amMCI - BOG
1 stop7h 55mDelta
mar. 12/25:15 pmBOG - MCI
2 stops17h 18mDelta
Deal found 7/28$587
This KAYAK deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/310:28 amMCI - MDE
2 stops19h 44mLATAM Airlines
lun. 10/137:39 amMDE - MCI
2 stops25h 34mLATAM Airlines
Deal found 7/28$594
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/256:15 amMCI - BOG
1 stop15h 20mUnited Airlines
lun. 12/11:30 amBOG - MCI
1 stop22h 00mUnited Airlines
Deal found 7/28$596
This American Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/35:06 amMCI - MDE
1 stop15h 09mAmerican Airlines
lun. 10/136:00 amMDE - MCI
1 stop16h 59mAmerican Airlines
Deal found 7/28$600
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 8/265:26 amSTL - LIM
1 stop16h 59mAmerican Airlines
mar. 9/96:30 amLIM - STL
1 stop17h 29mAmerican Airlines
Deal found 7/30$645

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 30, 2025.
Use the filters below to find and compare flights from Missouri to South America that are best for you.

Fly from

Missouri

Fly to

South America

Route

Depart

Return

Price

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

mar. 10/21

10:35 am-12:25 am

1 stop13h 50m

Medellín Jose Maria Cordova Intl

mié. 10/29

2:09 pm-9:40 am

1 stop19h 31m

$296

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

vie. 9/12

11:23 am-12:25 am

1 stop13h 02m

Medellín Jose Maria Cordova Intl

dom. 9/14

2:00 pm-11:07 pm

1 stop9h 07m

$331

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

vie. 9/5

5:15 am-12:00 pm

1 stop30h 45m

Bogotá El Dorado

lun. 9/8

12:55 pm-11:07 pm

1 stop10h 12m

$336

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

vie. 9/26

11:23 am-8:39 am

3 stops21h 16m

Bogotá El Dorado

lun. 9/29

12:55 pm-11:07 pm

1 stop10h 12m

$372

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

vie. 9/12

11:23 am-12:25 am

1 stop13h 02m

Medellín Jose Maria Cordova Intl

dom. 9/14

6:00 am-10:28 am

2 stops28h 28m

$386

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

jue. 8/21

10:37 am-6:50 pm

1 stop8h 13m

Medellín Jose Maria Cordova Intl

sáb. 8/23

10:20 am-9:40 am

1 stop23h 20m

$392

Kansas CitySao Paulo

MCI - GRU

MCIGRU

Kansas City

mié. 9/3

6:00 am-3:20 pm

2 stops31h 20m

Sao Paulo Guarulhos Intl

sáb. 9/6

1:45 am-11:07 pm

2 stops23h 22m

$584

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

vie. 10/3

10:28 am-6:12 am

2 stops19h 44m

Medellín Jose Maria Cordova Intl

lun. 10/13

7:39 am-9:13 am

2 stops25h 34m

$594

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

vie. 10/3

5:06 am-8:15 pm

1 stop15h 09m

Medellín Jose Maria Cordova Intl

lun. 10/13

6:00 am-10:59 pm

1 stop16h 59m

$600

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

mié. 9/10

5:32 am-9:17 pm

2 stops15h 45m

Bogotá El Dorado

mié. 9/17

6:30 am-8:47 pm

2 stops14h 17m

$604

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/28

Showing 1-10 of 57 results
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Best time to book a flight from Missouri to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to South America

What is the cheapest month to book a flight from Missouri to South America?

Currently, May is the cheapest month in which you can book a flight from Missouri to South America (average of $359). Flying from Missouri to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SA?

Find hourly flight availability from Missouri to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated julio 30, 2025.

When flying from Missouri to South America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated julio 30, 2025.
Read reviews from past customers who have flown Delta, LATAM Airlines, and Copa Airlines from Missouri to South America. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,822 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Copa Airlines
7.5
Good
1,493 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,896 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
GOL
7.3
Good
1,091 reviews
Delta
8.0
Very good
7,980 reviews

Boarding

8.2

Crew

8.5

Food

7.3

Overall

8.0

Comfort

7.9

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Missouri to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Missouri to South America one-way?

    $135 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on United Airlines and Copa Airlines, with prices starting from $313 and $325, respectively.

  • Can I find deals for flights from Missouri to South America that include hotel bookings?

    Yes. In addition to deals on Missouri to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South America.

  • Can I find deals for business class flights from Missouri to South America?

    Yes. Cheapflights offers flight deals from Missouri to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to South America?

    Currently, May is the cheapest month in which you can book a flight from Missouri to South America (average of $359). Flying from Missouri to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Alternative routes for Missouri to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Missouri to South America

Discover the top 6 airlines that operate flights from Missouri to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated julio 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$320Average$447FlexibilityNo cancel feeOn-time65%
United AirlinesCheapest$399Average$884FlexibilityNo cancel feeOn-time69%
LATAM AirlinesCheapest$403Average$873FlexibilityNo cancel feeOn-time81%
DeltaCheapest$409Average$923FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$452Average$910FlexibilityNo cancel feeOn-time71%
Air CanadaCheapest$758Average$767FlexibilityNo cancel feeOn-time67%

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