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South America

$150+ Cheap flights from Missouri to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/5. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BOG
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Missouri to South America

Cheapest flights from Missouri to South America
Explore the most affordable flight options available from Missouri to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/43:30 pmSTL - BOG
1 stop20h 22mMultiple Airlines
Tue 12/91:47 pmBOG - STL
1 stop9h 46mMultiple Airlines
Deal found 10/30$349
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/43:30 pmSTL - BOG
1 stop20h 22mMultiple Airlines
Sun 12/141:47 pmBOG - STL
1 stop20h 12mMultiple Airlines
Deal found 10/30$360
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/43:30 pmSTL - BOG
1 stop20h 22mMultiple Airlines
Sat 12/131:47 pmBOG - STL
1 stop9h 46mMultiple Airlines
Deal found 10/30$368
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/53:30 pmSTL - BOG
1 stop20h 22mMultiple Airlines
Fri 12/121:47 pmBOG - STL
1 stop9h 46mMultiple Airlines
Deal found 10/29$372
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/43:30 pmSTL - BOG
1 stop20h 22mMultiple Airlines
Wed 12/102:17 amBOG - STL
1 stop12h 35mMultiple Airlines
Deal found 10/30$376
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/43:30 pmSTL - BOG
1 stop20h 22mMultiple Airlines
Mon 12/151:47 pmBOG - STL
1 stop9h 46mMultiple Airlines
Deal found 10/30$379
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/33:30 pmSTL - BOG
1 stop20h 22mMultiple Airlines
Tue 12/91:47 pmBOG - STL
1 stop9h 46mMultiple Airlines
Deal found 10/30$382
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/87:43 pmSTL - BOG
2 stops16h 09mMultiple Airlines
Thu 12/111:47 pmBOG - STL
1 stop9h 46mMultiple Airlines
Deal found 10/30$384
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:02 pmSTL - BOG
2 stops16h 58mSpirit Airlines
Sat 11/221:55 pmBOG - STL
2 stops21h 08mSpirit Airlines
Deal found 10/29$389
This Kiwi.com deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/33:30 pmSTL - BOG
1 stop20h 22mMultiple Airlines
Sat 12/131:47 pmBOG - STL
1 stop9h 46mMultiple Airlines
Deal found 10/30$402
This Kiwi.com deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/113:30 pmSTL - MDE
1 stop18h 25mMultiple Airlines
Sun 12/142:54 pmMDE - STL
1 stop19h 05mMultiple Airlines
Deal found 10/29$418
This CheapOair deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2811:51 amSTL - MDE
1 stop12h 37mSpirit Airlines
Wed 1/281:51 amMDE - STL
1 stop10h 10mSpirit Airlines
Deal found 10/28$447

Cheap flight deals from Missouri to South America

Keep the following information in mind while searching for Missouri to South America flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$288
(Kiwi.com)

One-way from

$150
(Kiwi.com)

Popular in

January

Cheapest in

April

Average price

$1,118
Provider with most accurate pricing for Lambert-St Louis-Sao Paulo (SAO) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Sao Paulo (SAO) flights.
Search Deals
From Missouri to South America
Search Deals
One-way flight from Missouri to South America
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($122 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($31 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Missouri to South America that are best for you.

Fly from

Missouri

Fly to

South America

Route

Depart

Return

Price

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sun 1/11

12:20 pm-1:55 pm

2 stops24h 35m

Medellín Jose Maria Cordova Intl

Wed 1/21

12:09 pm-10:33 pm

1 stop11h 24m

$364

St. LouisBogotá

STL - BOG

STLBOG

Lambert-St Louis

Fri 12/5

3:30 pm-12:52 pm

1 stop20h 22m

Bogotá El Dorado

Fri 12/12

1:47 pm-9:47 am

2 stops45h 00m

$377

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sat 1/10

5:11 pm-11:03 am

1 stop16h 52m

Medellín Jose Maria Cordova Intl

Thu 1/22

12:09 pm-10:33 pm

1 stop11h 24m

$390

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sat 1/10

2:48 pm-12:56 am

1 stop9h 08m

Medellín Jose Maria Cordova Intl

Tue 1/20

10:45 pm-10:33 pm

2 stops24h 48m

$407

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Thu 12/11

2:47 pm-1:09 am

1 stop9h 22m

Medellín Jose Maria Cordova Intl

Sun 12/14

3:10 pm-9:52 am

2 stops19h 42m

$431

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sun 1/11

12:20 pm-2:16 pm

1 stop24h 56m

Medellín Jose Maria Cordova Intl

Fri 1/16

6:35 am-10:37 pm

1 stop17h 02m

$438

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sun 12/28

11:51 am-1:28 am

1 stop12h 37m

Medellín Jose Maria Cordova Intl

Wed 1/28

1:51 am-11:01 am

1 stop10h 10m

$447

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Fri 11/14

4:56 pm-9:00 am

2 stops15h 04m

Medellín Jose Maria Cordova Intl

Wed 11/19

1:00 pm-9:58 am

1 stop21h 58m

$470

Kansas CityLima

MCI - LIM

MCILIM

Kansas City

Fri 12/5

3:47 pm-10:35 pm

2 stops29h 48m

Lima J Chavez Intl

Wed 12/10

11:37 pm-11:15 pm

2 stops24h 38m

$497

St. LouisMedellín

STL - MDE

STLMDE

Lambert-St Louis

Sun 1/11

12:20 pm-12:56 am

1 stop11h 36m

Medellín Jose Maria Cordova Intl

Wed 1/21

12:09 pm-11:01 am

3 stops23h 52m

$508

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Showing 1-10 of 55 results
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Best time to book a flight from Missouri to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to South America

What is the cheapest month to book a flight from Missouri to South America?

Currently, November is the cheapest month in which you can book a flight from Missouri to South America (average of $278). Flying from Missouri to South America in December is currently the most expensive (average of $469). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SA?

Find hourly flight availability from Missouri to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

It’s typically best to fly out from Missouri to South America in the evening. Doing so could potentially save you 29% on the flight price compared to flying in the morning, which is usually more expensive.

What is the cheapest day to fly from Missouri to South America?

Use this chart to determine the cheapest time to fly round-trip from Missouri to South America. Price data was last updated on December 8, 2024.

Travelers seeking maximum savings on their Missouri to South America flight should consider departing on Thursday mornings when fares are most often at their lowest. Thursday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Missouri to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to South America?

    For as low as $636, Spirit Airlines can have you in South America from Missouri in 14h 15m. Airlines will cover a distance of 3720 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Missouri to South America that include hotel bookings?

    Yes. In addition to deals on Missouri to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South America.

  • Can I find deals for business class flights from Missouri to South America?

    Yes. Cheapflights offers flight deals from Missouri to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to South America?

    Currently, November is the cheapest month in which you can book a flight from Missouri to South America (average of $278). Flying from Missouri to South America in December is currently the most expensive (average of $469). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 6 airlines flying from Missouri to South America

Discover the top 6 airlines that operate flights from Missouri to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$303Average$386FlexibilityNo cancel feeOn-time65%
DeltaCheapest$439Average$930FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$441Average$959FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$452Average$898FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$535Average$914FlexibilityNo cancel feeOn-time81%
Air CanadaCheapest$758Average$766FlexibilityNo cancel feeOn-time67%

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