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South America

$168+ Cheap flights from Missouri to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BOG
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from Missouri to South America

Keep the following information in mind while searching for Missouri to South America flight deals. Data was last updated May 1, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$430
(FlightHub)

One-way from

$168
(FlightHub)

Popular in

September

Cheapest in

February

Average price

$1,406
Provider with most accurate pricing for Kansas City-Sao Paulo (SAO) flight deals.
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Provider most trusted by Cheapflights users for Kansas City-Sao Paulo (SAO) flights.
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From Missouri to South America
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One-way flight from Missouri to South America
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High demand for flights, 0% potential price rise
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Cheapest flight prices on average. 2% potential price decrease ($31 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Find flight deals from Missouri to South America

Cheapest flights from Missouri to South America
Explore the most affordable flight options available from Missouri to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This FlightHub deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/55:46 amMCI - MDE
1 stop7h 12mSpirit Airlines
Mon 6/91:53 pmMDE - MCI
1 stop8h 48mSpirit Airlines
Deal found 4/30$430
This Kiwi.com deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/136:00 amMCI - BOG
1 stop29h 59mSpirit Airlines
Fri 6/2712:55 pmBOG - MCI
1 stop9h 06mSpirit Airlines
Deal found 4/30$451
This Avianca Connect deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/45:46 amMCI - BOG
1 stop12h 28mMultiple Airlines
Wed 6/119:20 amBOG - MCI
1 stop13h 21mMultiple Airlines
Deal found 4/30$469
This Avianca Connect deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/286:43 pmMCI - MDE
1 stop20h 47mMultiple Airlines
Thu 8/215:59 amMDE - MCI
1 stop11h 39mMultiple Airlines
Deal found 4/30$496
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/11:13 pmMCI - BOG
2 stops21h 42mDelta
Mon 7/141:35 amBOG - MCI
2 stops15h 53mDelta
Deal found 4/30$591
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/288:25 amMCI - MDE
1 stop12h 45mUnited Airlines
Thu 8/219:45 amMDE - MCI
2 stops23h 24mUnited Airlines
Deal found 4/30$594
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/207:00 amMCI - BOG
1 stop15h 30mAmerican Airlines
Tue 7/2912:25 pmBOG - MCI
1 stop11h 53mAmerican Airlines
Deal found 4/30$597
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/42:56 pmMCI - BOG
1 stop13h 58mUnited Airlines
Tue 6/1012:14 amBOG - MCI
1 stop11h 55mUnited Airlines
Deal found 4/30$613
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/19:36 amMCI - MDE
2 stops13h 59mAmerican Airlines
Fri 7/1112:45 amMDE - MCI
1 stop23h 33mAmerican Airlines
Deal found 4/30$618
This eDestinos deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/17:56 pmMCI - LIM
2 stops24h 19mLATAM Airlines
Wed 6/1112:15 pmLIM - MCI
1 stop11h 51mLATAM Airlines
Deal found 4/30$620
This eDestinos deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/15:26 pmMCI - BOG
2 stops17h 29mLATAM Airlines
Wed 6/1110:15 amBOG - MCI
2 stops12h 26mLATAM Airlines
Deal found 4/30$622
This Avianca deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/268:15 amSTL - LIM
2 stops17h 30mAvianca
Tue 9/96:45 pmLIM - STL
2 stops15h 17mAvianca
Deal found 4/30$624

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Missouri to South America that are best for you.

Fly from

Missouri

Fly to

South America

Route

Depart

Return

Price

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Thu 6/5

5:46 am-12:58 pm

1 stop7h 12m

Medellín Jose Maria Cordova Intl

Mon 6/9

1:53 pm-10:41 pm

1 stop8h 48m

$430

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

Fri 6/13

6:00 am-11:59 am

1 stop29h 59m

Bogotá El Dorado

Fri 6/27

12:55 pm-10:01 pm

1 stop9h 06m

$451

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

Wed 6/4

5:46 am-6:14 pm

1 stop12h 28m

Bogotá El Dorado

Wed 6/11

9:20 am-10:41 pm

1 stop13h 21m

$469

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Mon 7/28

6:43 pm-3:30 pm

1 stop20h 47m

Medellín Jose Maria Cordova Intl

Thu 8/21

5:59 am-5:38 pm

1 stop11h 39m

$496

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

Tue 7/1

1:13 pm-10:55 am

2 stops21h 42m

Bogotá El Dorado

Mon 7/14

1:35 am-5:28 pm

2 stops15h 53m

$591

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Mon 7/28

8:25 am-9:10 pm

1 stop12h 45m

Medellín Jose Maria Cordova Intl

Thu 8/21

9:45 am-9:09 am

2 stops23h 24m

$594

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

Sun 7/20

7:00 am-10:30 pm

1 stop15h 30m

Bogotá El Dorado

Tue 7/29

12:25 pm-12:18 am

1 stop11h 53m

$597

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

Wed 6/4

2:56 pm-4:54 am

1 stop13h 58m

Bogotá El Dorado

Tue 6/10

12:14 am-12:09 pm

1 stop11h 55m

$613

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Tue 7/1

9:36 am-11:35 pm

2 stops13h 59m

Medellín Jose Maria Cordova Intl

Fri 7/11

12:45 am-12:18 am

1 stop23h 33m

$618

Kansas CityLima

MCI - LIM

MCILIM

Kansas City

Sun 6/1

7:56 pm-8:15 pm

2 stops24h 19m

Lima J Chavez Intl

Wed 6/11

12:15 pm-12:06 am

1 stop11h 51m

$620

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Showing 1-10 of 43 results
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Best time to book a flight from Missouri to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to South America

What is the cheapest month to book a flight from Missouri to South America?

Currently, May is the cheapest month in which you can book a flight from Missouri to South America (average of $359). Flying from Missouri to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SA?

Find hourly flight availability from Missouri to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

When flying from Missouri to South America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated May 1, 2025.
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,767 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.5
Good
1,415 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,696 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,934 reviews

Overall

8.0

Entertainment

7.9

Comfort

7.9

Boarding

8.2

Crew

8.5

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Missouri to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Missouri to South America one-way?

    $168 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on Copa Airlines and Delta, with prices starting from $323 and $323, respectively.

  • Can I find deals for flights from Missouri to South America that include hotel bookings?

    Yes. In addition to deals on Missouri to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South America.

  • Can I find deals for business class flights from Missouri to South America?

    Yes. Cheapflights offers flight deals from Missouri to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to South America?

    Currently, May is the cheapest month in which you can book a flight from Missouri to South America (average of $359). Flying from Missouri to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Missouri to South America

Discover the top 5 airlines that operate flights from Missouri to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$271Average$447FlexibilityNo cancel feeOn-time65%
DeltaCheapest$389Average$943FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$399Average$872FlexibilityNo cancel feeOn-time69%
LATAM AirlinesCheapest$409Average$986FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$449Average$904FlexibilityNo cancel feeOn-time71%

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