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South America

$155+ Cheap flights from Missouri to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/1. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BOG
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheap flight deals from Missouri to South America

Keep the following information in mind while searching for Missouri to South America flight deals. Data was last updated June 12, 2025.

Round-trip from

$355
(FlightHub)

One-way from

$155
(SmartFares)

Popular in

June

Cheapest in

February

Average price

$1,413
From Missouri to South America
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One-way flight from Missouri to South America
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Highest demand for flights based on searches. 9% potential increase in price ($122 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($28 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Missouri to South America

Cheapest flights from Missouri to South America
Explore the most affordable flight options available from Missouri to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This FlightHub deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:43 pmMCI - BOG
1 stop17h 14mSpirit Airlines
Wed 9/1712:52 pmBOG - MCI
1 stop28h 46mSpirit Airlines
Deal found 6/11$355
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/310:35 amMCI - MDE
2 stops27h 19mDelta
Tue 10/79:53 pmMDE - MCI
2 stops26h 04mDelta
Deal found 6/11$390
This KAYAK deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2410:38 amMCI - MDE
2 stops22h 35mLATAM Airlines
Sun 7/2710:55 pmMDE - MCI
2 stops24h 01mLATAM Airlines
Deal found 6/10$400
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:43 pmMCI - MDE
1 stop18h 08mSpirit Airlines
Tue 10/71:46 pmMDE - MCI
1 stop27h 52mSpirit Airlines
Deal found 6/11$422
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/116:04 pmMCI - BOG
1 stop19h 01mMultiple Airlines
Tue 8/2610:41 pmBOG - MCI
2 stops42h 57mMultiple Airlines
Deal found 6/11$458
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/46:05 amMCI - MDE
2 stops26h 12mMultiple Airlines
Fri 7/182:10 pmMDE - MCI
1 stop26h 59mMultiple Airlines
Deal found 6/11$500
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/118:25 amMCI - BOG
1 stop10h 55mUnited Airlines
Tue 8/268:30 amBOG - MCI
1 stop13h 56mUnited Airlines
Deal found 6/11$587
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/18:10 amMCI - MDE
1 stop13h 00mUnited Airlines
Mon 10/139:45 amMDE - MCI
1 stop12h 42mUnited Airlines
Deal found 6/11$590
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/115:50 amMCI - BOG
1 stop7h 50mDelta
Mon 8/251:35 amBOG - MCI
2 stops15h 23mDelta
Deal found 6/11$591
This Justfly.com deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/110:35 amMCI - BOG
1 stop8h 40mLATAM Airlines
Sat 10/119:00 amBOG - MCI
1 stop10h 01mLATAM Airlines
Deal found 6/12$592
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/285:16 amMCI - MDE
1 stop7h 19mAmerican Airlines
Tue 11/43:20 amMDE - MCI
1 stop21h 17mAmerican Airlines
Deal found 6/10$603
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/145:45 amMCI - BOG
1 stop16h 45mAmerican Airlines
Mon 8/1812:25 amBOG - MCI
1 stop16h 56mAmerican Airlines
Deal found 6/11$611

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Missouri to South America that are best for you.

Fly from

Missouri

Fly to

South America

Route

Depart

Return

Price

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

Wed 9/10

6:43 pm-11:57 am

1 stop17h 14m

Bogotá El Dorado

Wed 9/17

12:52 pm-5:38 pm

1 stop28h 46m

$355

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Thu 7/24

10:38 am-9:13 am

2 stops22h 35m

Medellín Jose Maria Cordova Intl

Sun 7/27

10:55 pm-10:56 pm

2 stops24h 01m

$400

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

Mon 8/11

6:04 pm-1:05 pm

1 stop19h 01m

Bogotá El Dorado

Tue 8/26

10:41 pm-5:38 pm

2 stops42h 57m

$458

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Tue 7/29

4:23 pm-1:04 pm

1 stop20h 41m

Medellín Jose Maria Cordova Intl

Tue 8/5

1:59 pm-3:17 pm

1 stop25h 18m

$473

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Fri 7/4

6:05 am-8:17 am

2 stops26h 12m

Medellín Jose Maria Cordova Intl

Fri 7/18

2:10 pm-5:09 pm

1 stop26h 59m

$500

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Fri 7/25

5:45 am-10:35 pm

2 stops16h 50m

Medellín Jose Maria Cordova Intl

Sun 7/27

5:56 am-8:40 pm

2 stops14h 44m

$522

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

Mon 8/11

8:25 am-7:20 pm

1 stop10h 55m

Bogotá El Dorado

Tue 8/26

8:30 am-10:26 pm

1 stop13h 56m

$587

Kansas CityMedellín

MCI - MDE

MCIMDE

Kansas City

Wed 7/30

8:25 am-9:10 pm

1 stop12h 45m

Medellín Jose Maria Cordova Intl

Tue 8/5

12:15 am-2:18 pm

1 stop14h 03m

$590

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

Mon 8/11

5:50 am-1:40 pm

1 stop7h 50m

Bogotá El Dorado

Mon 8/25

1:35 am-4:58 pm

2 stops15h 23m

$591

Kansas CityBogotá

MCI - BOG

MCIBOG

Kansas City

Wed 10/1

10:35 am-7:15 pm

1 stop8h 40m

Bogotá El Dorado

Sat 10/11

9:00 am-7:01 pm

1 stop10h 01m

$592

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Showing 1-10 of 48 results
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Best time to book a flight from Missouri to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to South America

What is the cheapest month to book a flight from Missouri to South America?

Currently, May is the cheapest month in which you can book a flight from Missouri to South America (average of $359). Flying from Missouri to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to SA?

Find hourly flight availability from Missouri to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

When flying from Missouri to South America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated June 12, 2025.
Delta
8.0
Very good
7,950 reviews

Overall

8.0

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,950 reviews
Delta
8.0
Very good
7,950 reviews

Overall

8.0

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,785 reviews
Delta
8.0
Very good
7,950 reviews

Overall

8.0

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Copa Airlines
7.5
Good
1,451 reviews
Delta
8.0
Very good
7,950 reviews

Overall

8.0

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
SWISS
7.5
Good
1,623 reviews
Delta
8.0
Very good
7,950 reviews

Overall

8.0

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,950 reviews

Overall

8.0

Entertainment

7.9

Food

7.3

Boarding

8.2

Comfort

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Missouri to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Missouri to South America one-way?

    $155 is the cheapest one-way deal found within the past few days, from Spirit Airlines. You may also be able to find cheap deals on Delta and United Airlines, with prices starting from $313 and $323, respectively.

  • Can I find deals for flights from Missouri to South America that include hotel bookings?

    Yes. In addition to deals on Missouri to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to South America.

  • Can I find deals for business class flights from Missouri to South America?

    Yes. Cheapflights offers flight deals from Missouri to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to South America?

    Currently, May is the cheapest month in which you can book a flight from Missouri to South America (average of $359). Flying from Missouri to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from Missouri to South America

Discover the top 6 airlines that operate flights from Missouri to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$289Average$939FlexibilityNo cancel feeOn-timeN/A
Spirit AirlinesCheapest$293Average$452FlexibilityNo cancel feeOn-time65%
United AirlinesCheapest$399Average$883FlexibilityNo cancel feeOn-time69%
LATAM AirlinesCheapest$409Average$914FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$462Average$929FlexibilityNo cancel feeOn-time71%
Air CanadaCheapest$758Average$767FlexibilityNo cancel feeOn-time67%

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