How long is the flight from Mississippi to South America?

Delta, LATAM Airlines, and American Airlines can get you from Mississippi to South America in just under 15h 30m. Your travel time can differ by up to 10h 45m. Mississippi and South America are separated by a distance of 3357 mi. This flight may include one or multiple stops.

What are the cheapest airlines to fly from Mississippi to South America one-way?

The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $361. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Mississippi to South America for a low price.

What is the cheapest month to book a flight from Mississippi to South America?

Currently, May is the cheapest month in which you can book a flight from Mississippi to South America (average of $359). Flying from Mississippi to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Can I find deals for flights from Mississippi to South America that include hotel bookings?

Yes. In addition to deals on Mississippi to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Mississippi to South America?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to South America.

Can I find deals for business class flights from Mississippi to South America?

Yes. Cheapflights offers flight deals from Mississippi to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$351+ Flights from Mississippi to South America

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Cheap flight deals from Mississippi to South America

Round-trip from	$595 (Delta)
One-way from	$351 (Kiwi.com)

From Mississippi to South America

Search Deals

One-way flight from Mississippi to South America

Search Deals

Find flight deals from Mississippi to South America

Cheapest flights from Mississippi to South America
Explore the most affordable flight options available from Mississippi to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

Tue 10/145:43 amMOB - LIM

1 stop15h 27mDelta

Tue 10/2811:40 pmLIM - MOB

1 stop12h 52mDelta

Deal found 9/14

$595

Sat 11/16:33 amMEM - LIM

1 stop17h 07mUnited Airlines

Tue 11/181:50 amLIM - MEM

1 stop15h 06mUnited Airlines

Deal found 9/14

$615

Sat 11/17:05 amMEM - LIM

2 stops14h 35mDelta

Tue 11/1812:20 amLIM - MEM

2 stops12h 23mDelta

Deal found 9/14

$619

Thu 10/307:00 amMEM - GRU

2 stops31h 15mMultiple Airlines

Wed 11/52:40 amGRU - MEM

2 stops15h 34mMultiple Airlines

Deal found 9/15

$632

Sat 10/46:50 amBTR - GYE

2 stops16h 47mUnited Airlines

Wed 10/812:15 pmGYE - BTR

2 stops35h 07mUnited Airlines

Deal found 9/15

$677

Sun 10/128:05 amMEM - LIM

1 stop13h 05mDelta

Fri 11/1412:10 amLIM - MEM

2 stops17h 41mDelta

Deal found 9/14

$710

Thu 9/258:43 amMEM - LIM

2 stops16h 17mMultiple Airlines

Tue 10/73:00 amLIM - MEM

2 stops28h 42mMultiple Airlines

Deal found 9/14

$712

Sun 10/126:15 pmMEM - LIM

1 stop9h 55mAmerican Airlines

Fri 11/1412:45 amLIM - MEM

2 stops14h 10mAmerican Airlines

Deal found 9/15

$714

Fri 11/74:19 pmMEM - GRU

1 stop13h 31mMultiple Airlines

Wed 11/121:40 amGRU - MEM

2 stops16h 34mMultiple Airlines

Deal found 9/13

$751

Sun 10/127:00 amMEM - LIM

1 stop16h 00mUnited Airlines

Fri 11/141:50 amLIM - MEM

1 stop17h 18mUnited Airlines

Deal found 9/14

$762

Mon 10/137:00 amMEM - GRU

3 stops30h 20mMultiple Airlines

Mon 10/204:50 pmGRU - MEM

2 stops28h 55mMultiple Airlines

Deal found 9/15

$798

Tue 10/149:20 amMOB - LIM

1 stop13h 40mUnited Airlines

Mon 10/271:30 amLIM - MOB

1 stop12h 52mUnited Airlines

Deal found 9/14

$822

Best flights from Mississippi to South America
Discover carefully curated flight deals from Mississippi to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2025.

Tue 10/149:13 amMOB - LIM

2 stops22h 47mDelta

Mon 10/2712:10 amLIM - MOB

2 stops22h 38mDelta

Deal found 9/14

$595

Sat 11/17:05 amMEM - LIM

2 stops26h 15mLATAM Airlines

Wed 11/1912:15 pmLIM - MEM

1 stop11h 03mLATAM Airlines

Deal found 9/14

$615

Sat 11/16:00 amMEM - LIM

1 stop15h 30mAmerican Airlines

Tue 11/1812:45 amLIM - MEM

1 stop17h 59mAmerican Airlines

Deal found 9/16

$615

Sat 11/16:33 amMEM - LIM

1 stop17h 07mUnited Airlines

Tue 11/181:50 amLIM - MEM

1 stop15h 06mUnited Airlines

Deal found 9/14

$615

Thu 10/307:00 amMEM - GRU

2 stops31h 15mMultiple Airlines

Wed 11/52:40 amGRU - MEM

2 stops15h 34mMultiple Airlines

Deal found 9/15

$632

Sat 11/17:05 amMEM - LIM

2 stops14h 35mDelta

Tue 11/1812:20 amLIM - MEM

2 stops12h 23mDelta

Deal found 9/14

$619

Sat 10/46:50 amBTR - GYE

2 stops16h 47mUnited Airlines

Wed 10/812:15 pmGYE - BTR

2 stops11h 07mUnited Airlines

Deal found 9/13

$677

Fri 11/74:19 pmMEM - GRU

1 stop13h 31mMultiple Airlines

Wed 11/121:40 amGRU - MEM

2 stops16h 34mMultiple Airlines

Deal found 9/13

$751

Sun 10/128:05 amMEM - LIM

1 stop13h 05mDelta

Sat 11/1512:15 pmLIM - MEM

1 stop12h 05mDelta

Deal found 9/14

$710

Sun 12/2810:53 amMOB - LIM

2 stops17h 17mAmerican Airlines

Sat 1/1012:26 amLIM - MOB

2 stops22h 07mAmerican Airlines

Deal found 9/14

$832

Mon 10/137:00 amMEM - GRU

3 stops30h 20mMultiple Airlines

Mon 10/204:50 pmGRU - MEM

2 stops28h 55mMultiple Airlines

Deal found 9/15

$798

Tue 10/149:20 amMOB - LIM

1 stop13h 40mUnited Airlines

Mon 10/271:30 amLIM - MOB

1 stop12h 52mUnited Airlines

Deal found 9/14

$822

Sun 9/285:15 amMOB - LIM

2 stops17h 10mAmerican Airlines

Sun 10/56:30 amLIM - MOB

2 stops17h 29mAmerican Airlines

Deal found 9/15

$890

Sun 12/285:49 pmMOB - LIM

1 stop10h 11mDelta

Thu 1/812:15 pmLIM - MOB

1 stop21h 20mDelta

Deal found 9/16

$839

Sun 9/2812:45 pmMOB - LIM

2 stops34h 15mUnited Airlines

Sat 10/412:40 amLIM - MOB

1 stop11h 03mUnited Airlines

Deal found 9/15

$892

Mon 1/129:47 amMEM - EZE

1 stop19h 43mAmerican Airlines

Sun 2/110:25 pmEZE - MEM

1 stop18h 29mAmerican Airlines

Deal found 9/14

$1,015

Sun 2/13:35 pmMEM - EZE

1 stop12h 45mDelta

Mon 2/98:55 pmEZE - MEM

1 stop20h 33mDelta

Deal found 9/14

$1,015

Tue 12/166:03 pmBTR - GYE

2 stops17h 07mMultiple Airlines

Tue 1/612:20 pmGYE - BTR

2 stops25h 57mMultiple Airlines

Deal found 9/14

$1,179

Thu 10/305:00 pmMEM - GRU

1 stop14h 30mUnited Airlines

Thu 11/69:45 pmGRU - MEM

1 stop22h 54mUnited Airlines

Deal found 9/15

$1,115

Sat 11/812:14 pmMEM - GRU

1 stop18h 21mDelta

Sat 11/157:35 amGRU - MEM

2 stops17h 43mDelta

Deal found 9/14

$1,120

Tue 10/147:00 amMEM - EZE

1 stop23h 00mUnited Airlines

Tue 10/219:00 pmEZE - MEM

1 stop14h 12mUnited Airlines

Deal found 9/15

$1,125

Sun 3/12:03 pmJAN - EZE

3 stops60h 07mMultiple Airlines

Wed 3/47:35 amEZE - JAN

2 stops30h 38mMultiple Airlines

Deal found 9/13

$1,378

Fri 10/35:52 pmMEM - EZE

1 stop13h 53mDelta

Fri 10/248:10 pmEZE - MEM

1 stop14h 54mDelta

Deal found 9/14

$1,215

Tue 12/1612:10 pmBTR - GYE

2 stops24h 24mUnited Airlines

Tue 1/612:20 pmGYE - BTR

2 stops28h 38mUnited Airlines

Deal found 9/14

$1,266

Wed 12/176:03 pmBTR - GYE

2 stops19h 27mMultiple Airlines

Tue 1/612:20 pmGYE - BTR

2 stops28h 38mMultiple Airlines

Deal found 9/14

$1,466

Sun 12/77:15 pmJAN - EZE

1 stop34h 45mDelta

Wed 12/104:05 amEZE - JAN

2 stops22h 16mDelta

Deal found 9/13

$1,418

Thu 10/212:10 pmBTR - REC

2 stops27h 15mUnited Airlines

Mon 10/612:35 pmREC - BTR

2 stops28h 49mUnited Airlines

Deal found 9/13

$1,510

Sun 3/112:10 pmJAN - EZE

1 stop16h 10mDelta

Wed 3/48:00 amEZE - JAN

2 stops27h 38mDelta

Deal found 9/15

$1,450

Thu 12/1810:33 amBTR - GYE

2 stops19h 47mDelta

Wed 1/74:30 pmGYE - BTR

2 stops21h 24mDelta

Deal found 9/14

$2,466

Mon 9/292:21 pmMEM - SCL

2 stops19h 09mLATAM Airlines

Sat 10/49:05 amSCL - MEM

3 stops27h 13mLATAM Airlines

Deal found 9/16

$5,708

Last-minute flights from Mississippi to South America
Discover last-minute flight deals from Mississippi to South America. Data last updated September 16, 2025 and is based on user searches.

Thu 9/258:43 amMEM - LIM

2 stops16h 17mMultiple Airlines

Tue 10/73:00 amLIM - MEM

2 stops28h 42mMultiple Airlines

Deal found 9/14

$712

Thu 9/2511:30 amMOB - LIM

1 stop11h 30mUnited Airlines

Tue 10/712:40 amLIM - MOB

2 stops33h 48mUnited Airlines

Deal found 9/14

$831

Thu 10/26:25 amMEM - LIM

2 stops15h 35mLATAM Airlines

Mon 10/612:55 pmLIM - MEM

2 stops20h 33mLATAM Airlines

Deal found 9/14

$829

Sat 10/46:50 amBTR - GYE

2 stops16h 47mUnited Airlines

Wed 10/812:15 pmGYE - BTR

2 stops35h 07mUnited Airlines

Deal found 9/15

$677

Sun 10/128:05 amMEM - LIM

1 stop13h 05mDelta

Sat 11/158:50 amLIM - MEM

2 stops15h 30mDelta

Deal found 9/14

$710

Sun 10/126:15 pmMEM - LIM

1 stop9h 55mAmerican Airlines

Sat 11/1510:55 pmLIM - MEM

2 stops14h 34mAmerican Airlines

Deal found 9/15

$714

Sun 10/127:00 amMEM - LIM

1 stop16h 00mUnited Airlines

Fri 11/141:50 amLIM - MEM

1 stop17h 18mUnited Airlines

Deal found 9/14

$762

Mon 10/137:00 amMEM - GRU

3 stops30h 20mMultiple Airlines

Mon 10/204:50 pmGRU - MEM

2 stops28h 55mMultiple Airlines

Deal found 9/15

$798

Tue 10/145:43 amMOB - LIM

1 stop15h 27mDelta

Mon 10/2712:10 amLIM - MOB

2 stops22h 38mDelta

Deal found 9/14

$595

Tue 10/149:20 amMOB - LIM

1 stop13h 40mUnited Airlines

Mon 10/271:30 amLIM - MOB

1 stop12h 52mUnited Airlines

Deal found 9/14

$822

Sun 10/1910:40 amMEM - LIM

2 stops19h 45mLATAM Airlines

Tue 10/218:50 amLIM - MEM

2 stops14h 06mLATAM Airlines

Deal found 9/14

$813

Thu 10/307:00 amMEM - GRU

2 stops31h 15mMultiple Airlines

Wed 11/52:40 amGRU - MEM

2 stops15h 34mMultiple Airlines

Deal found 9/15

$632

One-way flights from Mississippi to South America
Search for one-way flight options from Mississippi to South America. Find affordable one-way fares based on user searches. Data last updated September 16, 2025.

Fri 11/76:46 pmMEM - GRU

2 stops26h 24mMultiple Airlines

Deal found 9/15

$351

Mon 10/139:13 amMOB - LIM

1 stop11h 57mDelta

Deal found 9/14

$361

Fri 3/135:25 pmMEM - LIM

3 stops31h 25mMultiple Airlines

Deal found 9/13

$365

Sun 10/126:59 pmMOB - LIM

1 stop26h 11mDelta

Deal found 9/14

$374

Fri 3/136:30 pmMEM - LIM

1 stop9h 00mAmerican Airlines

Deal found 9/13

$410

Sat 10/119:13 amMOB - LIM

1 stop11h 57mDelta

Deal found 9/14

$412

Tue 12/169:31 amBTR - GYE

2 stops29h 49mMultiple Airlines

Deal found 9/14

$444

Fri 3/133:35 pmMEM - LIM

2 stops14h 50mDelta

Deal found 9/13

$445

Sun 9/218:49 pmMEM - SCL

3 stops55h 56mMultiple Airlines

Deal found 9/16

$510

Tue 12/1612:10 pmBTR - GYE

2 stops24h 24mUnited Airlines

Deal found 9/13

$614

Wed 12/173:57 pmBTR - GYE

2 stops21h 33mMultiple Airlines

Deal found 9/14

$823

Wed 12/176:57 amBTR - GYE

2 stops15h 09mAmerican Airlines

Deal found 9/13

$872

Cheapflights Fare Finder

Use the filters below to find and compare flights from Mississippi to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

MobileLima

MOB - LIM

MOBLIM

Mobile

Tue 10/14

9:13 am-8:00 am

2 stops22h 47m

Lima J Chavez Intl

Mon 10/27

12:10 am-10:48 pm

2 stops22h 38m

$595

MemphisLima

MEM - LIM

MEMLIM

Memphis

Sat 11/1

7:05 am-9:20 am

2 stops26h 15m

Lima J Chavez Intl

Wed 11/19

12:15 pm-10:18 pm

1 stop11h 03m

$615

MemphisLima

MEM - LIM

MEMLIM

Memphis

Sat 11/1

6:00 am-9:30 pm

1 stop15h 30m

Lima J Chavez Intl

Tue 11/18

12:45 am-5:44 pm

1 stop17h 59m

$615

MemphisLima

MEM - LIM

MEMLIM

Memphis

Sat 11/1

6:33 am-11:40 pm

1 stop17h 07m

Lima J Chavez Intl

Tue 11/18

1:50 am-3:56 pm

1 stop15h 06m

$615

MemphisLima

MEM - LIM

MEMLIM

Memphis

Sat 11/1

7:05 am-9:40 pm

2 stops14h 35m

Lima J Chavez Intl

Tue 11/18

12:20 am-11:43 am

2 stops12h 23m

$619

MemphisSao Paulo

MEM - GRU

MEMGRU

Memphis

Thu 10/30

7:00 am-4:15 pm

2 stops31h 15m

Sao Paulo Guarulhos Intl

Wed 11/5

2:40 am-3:14 pm

2 stops15h 34m

$632

Baton RougeGuayaquil

BTR - GYE

BTRGYE

Baton Rouge Ryan

Sat 10/4

6:50 am-11:37 pm

2 stops16h 47m

Guayaquil Jose Joaquin de Olmedo

Wed 10/8

12:15 pm-11:22 pm

2 stops11h 07m

$677

MemphisLima

MEM - LIM

MEMLIM

Memphis

Sun 10/12

8:05 am-9:10 pm

1 stop13h 05m

Lima J Chavez Intl

Sat 11/15

12:15 pm-11:20 pm

1 stop12h 05m

$710

MemphisSao Paulo

MEM - GRU

MEMGRU

Memphis

Fri 11/7

4:19 pm-8:50 am

1 stop13h 31m

Sao Paulo Guarulhos Intl

Wed 11/12

1:40 am-3:14 pm

2 stops16h 34m

$751

MemphisSao Paulo

MEM - GRU

MEMGRU

Memphis

Mon 10/13

7:00 am-3:20 pm

3 stops30h 20m

Sao Paulo Guarulhos Intl

Mon 10/20

4:50 pm-7:45 pm

2 stops28h 55m

$798

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 50 results

...

Best time to book a flight from Mississippi to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Mississippi with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to South America

What is the cheapest time of day to fly from MS to SA?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mississippi to South America as you normally would.

Related info for your journey

How long is the flight from Mississippi to South America?
Delta, LATAM Airlines, and American Airlines can get you from Mississippi to South America in just under 15h 30m. Your travel time can differ by up to 10h 45m. Mississippi and South America are separated by a distance of 3357 mi. This flight may include one or multiple stops.
What are the cheapest airlines to fly from Mississippi to South America one-way?
The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $361. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Mississippi to South America for a low price.
Can I find deals for flights from Mississippi to South America that include hotel bookings?
Yes. In addition to deals on Mississippi to South America flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Mississippi to South America?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to South America.
Can I find deals for business class flights from Mississippi to South America?
Yes. Cheapflights offers flight deals from Mississippi to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Mississippi to South America?
Currently, May is the cheapest month in which you can book a flight from Mississippi to South America (average of $359). Flying from Mississippi to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 2 airlines flying from Mississippi to South America

Airline	Cheapest	Average	Flexibility	On-time
United Airlines	Cheapest$544	Average$654	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$583	Average$725	FlexibilityNo cancel fee	On-timeN/A

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$351+ Cheap flights from Mississippi to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/7. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Mississippi to South America with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Mississippi to South America

Keep the following information in mind while searching for Mississippi to South America flight deals. Data was last updated September 16, 2025.

Round-trip from

One-way from

Find flight deals from Mississippi to South America

Cheapest flights from Mississippi to South AmericaExplore the most affordable flight options available from Mississippi to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

Explore the most affordable flight options available from Mississippi to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Mississippi to South America that are best for you.

Best time to book a flight from Mississippi to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Mississippi with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to South America

What is the cheapest time of day to fly from MS to SA?

Find hourly flight availability from Mississippi to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Mississippi to South America?

What are the cheapest airlines to fly from Mississippi to South America one-way?

Can I find deals for flights from Mississippi to South America that include hotel bookings?

How can I find direct flights from Mississippi to South America?

Can I find deals for business class flights from Mississippi to South America?

What is the cheapest month to book a flight from Mississippi to South America?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Mississippi to South America

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Mississippi to South America

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Book with Flexibility

Travel Smart

Cheapest flights from Mississippi to South America
Explore the most affordable flight options available from Mississippi to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.