South America

$284+ Cheap flights from Mississippi to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/15. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — BOG
May 6 — May 131
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Cheap flight deals from Mississippi to South America

Keep the following information in mind while searching for Mississippi to South America flight deals. Data was last updated May 1, 2025.

Most accurate provider

AranGrant
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$575
(Delta)

One-way from

$284
(Kiwi.com)
Provider with most accurate pricing for Jackson-Evers Intl-Sao Paulo (SAO) flight deals.
Provider most trusted by Cheapflights users for Jackson-Evers Intl-Sao Paulo (SAO) flights.
From Mississippi to South America
One-way flight from Mississippi to South America

Find flight deals from Mississippi to South America

Cheapest flights from Mississippi to South America
Explore the most affordable flight options available from Mississippi to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/105:50 amJAN - BOG
2 stops14h 04mDelta
Wed 7/161:35 amBOG - JAN
2 stops15h 40mDelta
Deal found 4/30$575
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/105:18 pmJAN - BOG
1 stop26h 02mUnited Airlines
Thu 7/178:30 amBOG - JAN
1 stop26h 49mUnited Airlines
Deal found 4/30$609
This American Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1012:49 pmJAN - BOG
1 stop9h 41mAmerican Airlines
Wed 7/1612:25 amBOG - JAN
1 stop23h 34mAmerican Airlines
Deal found 4/30$625
This United Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/127:00 amMEM - LIM
1 stop16h 00mUnited Airlines
Fri 11/141:50 amLIM - MEM
1 stop15h 28mUnited Airlines
Deal found 4/29$645
This LATAM Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1212:00 pmMEM - LIM
2 stops18h 25mLATAM Airlines
Sat 11/1512:15 pmLIM - MEM
1 stop11h 35mLATAM Airlines
Deal found 4/30$665
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/15:45 amMEM - LIM
2 stops14h 30mDelta
Sat 11/159:05 amLIM - MEM
2 stops14h 45mDelta
Deal found 4/29$681
This Avianca Connect deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/215:00 amMEM - LIM
2 stops19h 35mMultiple Airlines
Wed 7/302:50 amLIM - MEM
2 stops20h 07mMultiple Airlines
Deal found 4/28$726
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/218:45 amMEM - SCL
1 stop21h 15mDelta
Mon 10/2712:25 amSCL - MEM
2 stops19h 52mDelta
Deal found 4/29$754
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/111:43 amMEM - PEI
2 stops35h 41mUnited Airlines
Sun 7/66:17 amPEI - MEM
2 stops39h 57mUnited Airlines
Deal found 4/30$760
This Avianca Connect deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/225:00 amMEM - SCL
2 stops22h 15mMultiple Airlines
Mon 10/2712:45 amSCL - MEM
2 stops24h 12mMultiple Airlines
Deal found 4/30$795
This KAYAK deal was found by Cheapflights users on 4/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/156:25 amMEM - CUZ
3 stops18h 20mLATAM Airlines
Wed 7/2310:40 pmCUZ - MEM
3 stops25h 04mLATAM Airlines
Deal found 4/28$802
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/2211:25 amMOB - BOG
1 stop17h 29mUnited Airlines
Sun 5/2512:14 amBOG - MOB
1 stop11h 29mUnited Airlines
Deal found 4/30$862

Cheapflights Fare Finder

Customize your flight search to find flights from Mississippi to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Mississippi to South America that are best for you.

Fly from

Mississippi

Fly to

South America

Route

Depart

Return

Price

JacksonBogotá

JAN - BOG

JANBOG

Jackson-Evers Intl

Tue 6/10

5:50 am-7:15 pm

1 stop13h 25m

Bogotá El Dorado

Wed 7/16

1:35 am-5:15 pm

2 stops15h 40m

$575

JacksonBogotá

JAN - BOG

JANBOG

Jackson-Evers Intl

Tue 6/10

5:18 pm-7:20 pm

1 stop26h 02m

Bogotá El Dorado

Thu 7/17

8:30 am-11:19 am

1 stop26h 49m

$609

JacksonBogotá

JAN - BOG

JANBOG

Jackson-Evers Intl

Tue 6/10

12:49 pm-10:30 pm

1 stop9h 41m

Bogotá El Dorado

Wed 7/16

12:25 am-11:59 pm

1 stop23h 34m

$625

MemphisLima

MEM - LIM

MEMLIM

Memphis

Sun 10/12

7:00 am-11:00 pm

1 stop16h 00m

Lima J Chavez Intl

Fri 11/14

1:50 am-4:18 pm

1 stop15h 28m

$645

MemphisLima

MEM - LIM

MEMLIM

Memphis

Sun 10/12

12:00 pm-6:25 am

2 stops18h 25m

Lima J Chavez Intl

Sat 11/15

12:15 pm-10:50 pm

1 stop11h 35m

$665

MemphisLima

MEM - LIM

MEMLIM

Memphis

Fri 7/4

5:55 pm-5:00 am

1 stop11h 05m

Lima J Chavez Intl

Fri 7/11

12:05 am-6:27 pm

2 stops18h 22m

$749

MemphisSantiago

MEM - SCL

MEMSCL

Memphis

Tue 10/21

8:45 am-8:00 am

1 stop21h 15m

Santiago Arturo Merino Benitez

Mon 10/27

12:25 am-6:17 pm

2 stops19h 52m

$754

MemphisPereira

MEM - PEI

MEMPEI

Memphis

Tue 7/1

11:43 am-11:24 pm

2 stops35h 41m

Pereira Matecana

Sun 7/6

6:17 am-10:14 pm

2 stops39h 57m

$760

MemphisSantiago

MEM - SCL

MEMSCL

Memphis

Wed 10/22

5:00 am-5:15 am

2 stops22h 15m

Santiago Arturo Merino Benitez

Mon 10/27

12:45 am-10:57 pm

2 stops24h 12m

$795

MemphisCusco

MEM - CUZ

MEMCUZ

Memphis

Tue 7/15

6:25 am-12:45 am

3 stops18h 20m

Cusco Velazco Astete

Wed 7/23

10:40 pm-11:44 pm

3 stops25h 04m

$802

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/29

Showing 1-10 of 31 results
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Best time to book a flight from Mississippi to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to South America

What is the cheapest month to book a flight from Mississippi to South America?

Currently, May is the cheapest month in which you can book a flight from Mississippi to South America (average of $359). Flying from Mississippi to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MS to SA?

Find hourly flight availability from Mississippi to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mississippi to South America as you normally would.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated May 1, 2025.
8.0
Very good

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
8.0
Very good
8.0
Very good

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
8.0
Very good

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
8.0
Very good

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
8.0
Very good

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
8.0
Very good

Crew

8.5

Food

7.3

Boarding

8.2

Comfort

7.9

Overall

8.0

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • Can I find deals for flights from Mississippi to South America that include hotel bookings?

    Yes. In addition to deals on Mississippi to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to South America.

  • Can I find deals for business class flights from Mississippi to South America?

    Yes. Cheapflights offers flight deals from Mississippi to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to South America?

    Currently, May is the cheapest month in which you can book a flight from Mississippi to South America (average of $359). Flying from Mississippi to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Mississippi to South America

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Mississippi to South America

Discover the top 2 airlines that operate flights from Mississippi to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$528Average$658FlexibilityNo cancel feeOn-time69%
DeltaCheapest$583Average$674FlexibilityNo cancel feeOn-timeN/A

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