South America

$179+ Cheap flights from Mississippi to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/20. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — BOG
Nov 29 — Dec 61
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Cheap flight deals from Mississippi to South America

Keep the following information in mind while searching for Mississippi to South America flight deals. Data was last updated October 30, 2025.

Most accurate provider

AranGrant
2 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$468
(Priceline)

One-way from

$179
(Kiwi.com)
Provider with most accurate pricing for Jackson-Evers Intl-Sao Paulo (SAO) flight deals.
Provider most trusted by Cheapflights users for Jackson-Evers Intl-Sao Paulo (SAO) flights.
From Mississippi to South America
One-way flight from Mississippi to South America

Find flight deals from Mississippi to South America

Cheapest flights from Mississippi to South America
Explore the most affordable flight options available from Mississippi to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/117:42 pmMEM - CTG
2 stops16h 28mSpirit Airlines
Thu 12/182:15 pmCTG - MEM
3 stops30h 07mSpirit Airlines
Deal found 10/29$541
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1110:44 amMEM - CTG
2 stops9h 46mAmerican Airlines
Thu 12/188:00 amCTG - MEM
1 stop10h 52mAmerican Airlines
Deal found 10/29$553
This KAYAK deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/268:17 pmMEM - CTG
2 stops15h 53mSpirit Airlines
Mon 12/292:15 pmCTG - MEM
2 stops30h 07mSpirit Airlines
Deal found 10/29$576
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/237:11 pmMEM - LIM
2 stops28h 39mMultiple Airlines
Wed 12/3111:37 pmLIM - MEM
1 stop20h 30mMultiple Airlines
Deal found 10/28$579
This LATAM Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/12:21 pmBTR - LIM
1 stop13h 39mMultiple Airlines
Mon 12/812:15 pmLIM - BTR
1 stop10h 38mMultiple Airlines
Deal found 10/29$595
This Delta deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:00 amBTR - LIM
1 stop14h 20mDelta
Sun 12/712:15 amLIM - BTR
2 stops18h 59mDelta
Deal found 10/29$600
This KAYAK deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/137:25 pmMEM - CTG
2 stops16h 50mSpirit Airlines
Sun 11/162:20 pmCTG - MEM
2 stops30h 40mSpirit Airlines
Deal found 10/29$600
This FlightHub deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/286:00 amMEM - LIM
1 stop14h 20mLATAM Airlines
Wed 12/1012:15 pmLIM - MEM
1 stop21h 16mLATAM Airlines
Deal found 10/28$611
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/286:00 amMEM - LIM
1 stop14h 20mDelta
Wed 12/108:50 amLIM - MEM
2 stops15h 33mDelta
Deal found 10/27$615
This Mytrip deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/268:17 pmMEM - CTG
2 stops15h 53mMultiple Airlines
Mon 12/2911:28 amCTG - MEM
3 stops33h 14mMultiple Airlines
Deal found 10/29$646
This KAYAK deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/238:17 pmMEM - CTG
2 stops15h 53mSpirit Airlines
Wed 12/312:15 pmCTG - MEM
2 stops30h 07mSpirit Airlines
Deal found 10/30$647
This Travelocity deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/78:55 pmMEM - CTG
2 stops15h 20mMultiple Airlines
Mon 11/105:20 pmCTG - MEM
2 stops30h 44mMultiple Airlines
Deal found 10/29$660

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Mississippi to South America that are best for you.

Fly from

Mississippi

Fly to

South America

Route

Depart

Return

Price

MemphisCartagena

MEM - CTG

MEMCTG

Memphis

Thu 12/11

7:42 pm-1:10 pm

2 stops16h 28m

Cartagena Rafael Nunez

Thu 12/18

2:15 pm-7:22 pm

3 stops30h 07m

$541

MemphisCartagena

MEM - CTG

MEMCTG

Memphis

Fri 12/26

8:17 pm-1:10 pm

2 stops15h 53m

Cartagena Rafael Nunez

Mon 12/29

2:15 pm-7:22 pm

2 stops30h 07m

$576

Baton RougeLima

BTR - LIM

BTRLIM

Baton Rouge Ryan

Mon 12/1

2:21 pm-5:00 am

1 stop13h 39m

Lima J Chavez Intl

Mon 12/8

12:15 pm-9:53 pm

1 stop10h 38m

$595

Baton RougeLima

BTR - LIM

BTRLIM

Baton Rouge Ryan

Mon 12/1

6:00 am-9:20 pm

1 stop14h 20m

Lima J Chavez Intl

Sun 12/7

12:15 am-6:14 pm

2 stops18h 59m

$600

MemphisCartagena

MEM - CTG

MEMCTG

Memphis

Thu 11/13

7:25 pm-1:15 pm

2 stops16h 50m

Cartagena Rafael Nunez

Sun 11/16

2:20 pm-8:00 pm

2 stops30h 40m

$600

MemphisCartagena

MEM - CTG

MEMCTG

Memphis

Tue 3/17

6:15 am-11:00 pm

2 stops16h 45m

Cartagena Rafael Nunez

Thu 3/19

6:25 am-11:23 pm

2 stops16h 58m

$611

MemphisCartagena

MEM - CTG

MEMCTG

Memphis

Tue 3/17

7:00 am-1:15 pm

1 stop6h 15m

Cartagena Rafael Nunez

Thu 3/19

2:30 pm-9:35 am

1 stop19h 05m

$611

MemphisLima

MEM - LIM

MEMLIM

Memphis

Fri 11/28

6:00 am-9:20 pm

1 stop14h 20m

Lima J Chavez Intl

Tue 12/9

12:05 am-11:23 pm

2 stops24h 18m

$615

MemphisLima

MEM - LIM

MEMLIM

Memphis

Fri 11/28

9:00 am-11:55 pm

1 stop13h 55m

Lima J Chavez Intl

Tue 12/9

1:50 am-1:55 pm

1 stop13h 05m

$615

MemphisLima

MEM - LIM

MEMLIM

Memphis

Fri 11/28

6:00 am-9:20 pm

1 stop14h 20m

Lima J Chavez Intl

Wed 12/10

8:50 am-11:23 pm

2 stops15h 33m

$615

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 60 results
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Best time to book a flight from Mississippi to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to South America

What is the cheapest time of day to fly from MS to SA?

Find hourly flight availability from Mississippi to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 30, 2025.

When flying from Mississippi to South America, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 50% versus a flight in the evening.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How long is the flight from Mississippi to South America?

    Spirit Airlines, Delta, and United Airlines can get you from Mississippi to South America in just under 14h 20m. Your travel time can differ by up to 2h 25m. Mississippi and South America are separated by a distance of 3082 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Mississippi to South America that include hotel bookings?

    Yes. In addition to deals on Mississippi to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to South America.

  • Can I find deals for business class flights from Mississippi to South America?

    Yes. Cheapflights offers flight deals from Mississippi to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Mississippi to South America

See prices for flight routes from nearby airports that may be better suited for you.

Top 2 airlines flying from Mississippi to South America

Discover the top 2 airlines that operate flights from Mississippi to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$476Average$648FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$544Average$654FlexibilityNo cancel feeOn-time69%

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