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South America

$157+ Cheap flights from Mississippi to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/25. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — BOG
Jun 17 — Jun 241
Tue 6/17
Tue 6/24
1 adult, Economy
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Cheap flight deals from Mississippi to South America

Keep the following information in mind while searching for Mississippi to South America flight deals. Data was last updated June 12, 2025.

Round-trip from

$407
(FlightHub)

One-way from

$157
(Kiwi.com)
From Mississippi to South America
Search Deals
One-way flight from Mississippi to South America
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Find flight deals from Mississippi to South America

Cheapest flights from Mississippi to South America
Explore the most affordable flight options available from Mississippi to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

This FlightHub deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/255:00 pmMEM - CTG
1 stop19h 06mSpirit Airlines
Mon 9/291:14 pmCTG - MEM
2 stops33h 43mSpirit Airlines
Deal found 6/10$407
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/2411:49 amMEM - CTG
2 stops24h 21mMultiple Airlines
Mon 9/299:26 pmCTG - MEM
2 stops25h 31mMultiple Airlines
Deal found 6/10$449
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/85:45 amMEM - CTG
1 stop7h 01mDelta
Tue 11/113:06 pmCTG - MEM
1 stop8h 50mDelta
Deal found 6/10$574
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/86:20 pmMEM - CTG
2 stops17h 46mAmerican Airlines
Tue 11/114:25 pmCTG - MEM
2 stops18h 29mAmerican Airlines
Deal found 6/10$578
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/127:00 amMEM - LIM
1 stop16h 00mUnited Airlines
Fri 11/141:50 amLIM - MEM
1 stop19h 15mUnited Airlines
Deal found 6/10$635
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/133:35 pmMEM - LIM
2 stops14h 50mDelta
Fri 9/1912:15 amLIM - MEM
2 stops14h 10mDelta
Deal found 6/11$639
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/105:34 pmMEM - LIM
2 stops32h 11mMultiple Airlines
Mon 7/148:25 pmLIM - MEM
2 stops20h 04mMultiple Airlines
Deal found 6/10$649
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/135:54 amMEM - LIM
1 stop10h 21mAmerican Airlines
Sat 9/206:30 amLIM - MEM
1 stop16h 53mAmerican Airlines
Deal found 6/11$710
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/195:45 amMEM - CUZ
2 stops19h 00mDelta
Mon 10/278:55 pmCUZ - MEM
2 stops25h 55mDelta
Deal found 6/10$738
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/2510:12 amMEM - GRU
3 stops32h 58mMultiple Airlines
Fri 8/14:50 pmGRU - MEM
2 stops29h 23mMultiple Airlines
Deal found 6/10$761
This LATAM Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/156:15 pmMEM - CUZ
2 stops16h 30mLATAM Airlines
Wed 7/236:55 amCUZ - MEM
2 stops16h 49mLATAM Airlines
Deal found 6/10$781
This Avianca Connect deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/225:00 amMEM - SCL
2 stops22h 15mMultiple Airlines
Sun 10/2612:45 amSCL - MEM
2 stops24h 12mMultiple Airlines
Deal found 6/12$802

Cheapflights Fare Finder

Customize your flight search to find flights from Mississippi to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
Use the filters below to find and compare flights from Mississippi to South America that are best for you.

Fly from

Mississippi

Fly to

South America

Route

Depart

Return

Price

MemphisCartagena

MEM - CTG

MEMCTG

Memphis

Thu 9/25

5:00 pm-12:06 pm

1 stop19h 06m

Cartagena Rafael Nunez

Mon 9/29

1:14 pm-10:57 pm

2 stops33h 43m

$407

MemphisCartagena

MEM - CTG

MEMCTG

Memphis

Tue 6/24

11:49 am-12:10 pm

2 stops24h 21m

Cartagena Rafael Nunez

Mon 9/29

9:26 pm-10:57 pm

2 stops25h 31m

$449

MemphisCartagena

MEM - CTG

MEMCTG

Memphis

Sat 11/8

5:45 am-1:46 pm

1 stop7h 01m

Cartagena Rafael Nunez

Tue 11/11

3:06 pm-10:56 pm

1 stop8h 50m

$574

MemphisCartagena

MEM - CTG

MEMCTG

Memphis

Sat 11/8

6:20 pm-1:06 pm

2 stops17h 46m

Cartagena Rafael Nunez

Tue 11/11

4:25 pm-12:07 am

1 stop8h 42m

$578

MemphisLima

MEM - LIM

MEMLIM

Memphis

Sun 10/12

7:00 am-11:00 pm

1 stop16h 00m

Lima J Chavez Intl

Fri 11/14

1:50 am-8:05 pm

1 stop19h 15m

$635

MemphisLima

MEM - LIM

MEMLIM

Memphis

Sat 9/13

3:35 pm-6:25 am

2 stops14h 50m

Lima J Chavez Intl

Fri 9/19

12:15 am-2:25 pm

2 stops14h 10m

$639

MemphisLima

MEM - LIM

MEMLIM

Memphis

Thu 7/10

5:34 pm-1:45 am

2 stops32h 11m

Lima J Chavez Intl

Mon 7/14

8:25 pm-4:29 pm

2 stops20h 04m

$649

MemphisLima

MEM - LIM

MEMLIM

Memphis

Sat 9/13

5:54 am-4:15 pm

1 stop10h 21m

Lima J Chavez Intl

Sat 9/20

6:30 am-11:23 pm

1 stop16h 53m

$710

MemphisCusco

MEM - CUZ

MEMCUZ

Memphis

Sun 10/19

5:45 am-12:45 am

2 stops19h 00m

Cusco Velazco Astete

Mon 10/27

8:55 pm-10:50 pm

2 stops25h 55m

$738

MemphisSao Paulo

MEM - GRU

MEMGRU

Memphis

Fri 7/25

10:12 am-9:10 pm

3 stops32h 58m

Sao Paulo Guarulhos Intl

Fri 8/1

4:50 pm-8:13 pm

2 stops29h 23m

$761

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Showing 1-10 of 35 results
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Best time to book a flight from Mississippi to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to South America

What is the cheapest time of day to fly from MS to SA?

Find hourly flight availability from Mississippi to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 12, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mississippi to South America as you normally would.

Rainfall in South America by month

Plan your trip to South America by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

Temperature in South America by month

Plan your trip to South America by taking into account the average temperature totals by month.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated June 12, 2025.
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,950 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,785 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,790 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Air Canada
7.1
Good
9,531 reviews
Delta
8.0
Very good
7,950 reviews

Boarding

8.2

Comfort

7.9

Food

7.3

Overall

8.0

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Mississippi to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • Can I find deals for flights from Mississippi to South America that include hotel bookings?

    Yes. In addition to deals on Mississippi to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to South America.

  • Can I find deals for business class flights from Mississippi to South America?

    Yes. Cheapflights offers flight deals from Mississippi to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to South America?

    Currently, May is the cheapest month in which you can book a flight from Mississippi to South America (average of $359). Flying from Mississippi to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Mississippi to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Mississippi to South America

Discover the top 2 airlines that operate flights from Mississippi to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$528Average$658FlexibilityNo cancel feeOn-time69%
DeltaCheapest$583Average$683FlexibilityNo cancel feeOn-timeN/A

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