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South America

$356+ Cheap flights from Mississippi to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/6. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — BOG
Aug 5 — Aug 121
Tue 8/5
Tue 8/12
1 adult, Economy
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Cheap flight deals from Mississippi to South America

Keep the following information in mind while searching for Mississippi to South America flight deals. Data was last updated July 31, 2025.

Round-trip from

$540
(Trip.com)

One-way from

$261
(Trip.com)
From Mississippi to South America
Search Deals
One-way flight from Mississippi to South America
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Find flight deals from Mississippi to South America

Cheapest flights from Mississippi to South America
Explore the most affordable flight options available from Mississippi to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

This Trip.com deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/307:00 amMEM - GRU
2 stops41h 10mMultiple Airlines
Wed 9/34:10 amGRU - MEM
2 stops20h 24mMultiple Airlines
Deal found 7/30$540
This Avianca Connect deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/17:00 amMEM - LIM
2 stops18h 50mMultiple Airlines
Tue 11/182:55 amLIM - MEM
2 stops15h 32mMultiple Airlines
Deal found 7/30$543
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/63:45 pmGPT - LIM
1 stop12h 15mDelta
Wed 12/108:50 amLIM - GPT
2 stops38h 16mDelta
Deal found 7/30$615
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/17:05 amMEM - LIM
2 stops13h 40mDelta
Wed 11/1910:45 amLIM - MEM
2 stops13h 05mDelta
Deal found 7/31$615
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/17:02 amMEM - LIM
2 stops14h 28mAmerican Airlines
Tue 11/1812:45 amLIM - MEM
1 stop17h 57mAmerican Airlines
Deal found 7/31$619
This Avianca Connect deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/227:00 amMEM - SCL
2 stops20h 15mMultiple Airlines
Sun 10/261:35 amSCL - MEM
2 stops18h 18mMultiple Airlines
Deal found 7/31$680
This LATAM Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/126:00 amMEM - LIM
2 stops26h 00mLATAM Airlines
Fri 11/1412:05 amLIM - MEM
2 stops16h 59mLATAM Airlines
Deal found 7/31$692
This American Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2210:09 amMEM - SCL
2 stops19h 51mAmerican Airlines
Mon 10/279:15 pmSCL - MEM
2 stops18h 28mAmerican Airlines
Deal found 7/31$738
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/65:11 pmGPT - LIM
1 stop29h 44mUnited Airlines
Tue 12/91:50 amLIM - GPT
1 stop15h 12mUnited Airlines
Deal found 7/28$751
This Delta deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2812:13 pmMOB - LIM
2 stops17h 12mDelta
Thu 1/88:50 amLIM - MOB
2 stops24h 45mDelta
Deal found 7/30$817
This Delta deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2212:34 pmMEM - SCL
2 stops13h 56mDelta
Tue 10/2811:15 pmSCL - MEM
1 stop14h 14mDelta
Deal found 7/31$824
This United Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/27:00 amMEM - LIM
1 stop16h 00mUnited Airlines
Sun 10/512:40 amLIM - MEM
1 stop21h 07mUnited Airlines
Deal found 7/31$858

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Mississippi to South America that are best for you.

Fly from

Mississippi

Fly to

South America

Route

Depart

Return

Price

MemphisSao Paulo

MEM - GRU

MEMGRU

Memphis

Sat 8/30

7:00 am-2:10 am

2 stops41h 10m

Sao Paulo Guarulhos Intl

Wed 9/3

4:10 am-10:34 pm

2 stops20h 24m

$540

MemphisLima

MEM - LIM

MEMLIM

Memphis

Sat 11/1

7:00 am-1:50 am

2 stops18h 50m

Lima J Chavez Intl

Tue 11/18

2:55 am-5:27 pm

2 stops15h 32m

$543

GulfportLima

GPT - LIM

GPTLIM

Gulfport Biloxi Regional

Sat 12/6

3:45 pm-5:00 am

1 stop12h 15m

Lima J Chavez Intl

Wed 12/10

11:40 pm-9:38 am

1 stop10h 58m

$615

MemphisLima

MEM - LIM

MEMLIM

Memphis

Sat 11/1

7:05 am-8:45 pm

2 stops13h 40m

Lima J Chavez Intl

Wed 11/19

10:45 am-10:50 pm

2 stops13h 05m

$615

MemphisLima

MEM - LIM

MEMLIM

Memphis

Sat 11/1

7:02 am-9:30 pm

2 stops14h 28m

Lima J Chavez Intl

Tue 11/18

12:45 am-5:42 pm

1 stop17h 57m

$619

MemphisSantiago

MEM - SCL

MEMSCL

Memphis

Wed 10/22

7:00 am-5:15 am

2 stops20h 15m

Santiago Arturo Merino Benitez

Sun 10/26

1:35 am-5:53 pm

2 stops18h 18m

$680

MemphisLima

MEM - LIM

MEMLIM

Memphis

Sun 10/12

6:00 am-8:00 am

2 stops26h 00m

Lima J Chavez Intl

Fri 11/14

12:05 am-10:50 pm

2 stops23h 45m

$692

MemphisSantiago

MEM - SCL

MEMSCL

Memphis

Wed 10/22

10:09 am-8:00 am

2 stops19h 51m

Santiago Arturo Merino Benitez

Mon 10/27

9:15 pm-1:43 pm

2 stops18h 28m

$738

GulfportLima

GPT - LIM

GPTLIM

Gulfport Biloxi Regional

Sat 12/6

5:11 pm-11:55 pm

1 stop29h 44m

Lima J Chavez Intl

Tue 12/9

1:50 am-4:02 pm

1 stop15h 12m

$751

MobileLima

MOB - LIM

MOBLIM

Mobile

Sun 12/28

12:13 pm-6:25 am

2 stops17h 12m

Lima J Chavez Intl

Thu 1/8

8:50 am-8:35 am

2 stops24h 45m

$817

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Showing 1-10 of 40 results
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Best time to book a flight from Mississippi to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to South America

What is the cheapest time of day to fly from MS to SA?

Find hourly flight availability from Mississippi to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 31, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mississippi to South America as you normally would.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated July 31, 2025.
Peruse reviews from past customers who have flown with Delta, LATAM Airlines, and United Airlines from Mississippi to South America to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,981 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,822 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,900 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Air Canada
7.1
Good
9,851 reviews
Delta
8.0
Very good
7,981 reviews

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Mississippi to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Mississippi to South America one-way?

    The cheapest airline one-way is LATAM Airlines, with whom users have recently found tickets for as low as $535. However, be on the lookout for offers from United Airlines and Delta, as they are both options that can get you from Mississippi to South America for a low price.

  • Can I find deals for flights from Mississippi to South America that include hotel bookings?

    Yes. In addition to deals on Mississippi to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to South America.

  • Can I find deals for business class flights from Mississippi to South America?

    Yes. Cheapflights offers flight deals from Mississippi to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to South America?

    Currently, May is the cheapest month in which you can book a flight from Mississippi to South America (average of $359). Flying from Mississippi to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Mississippi to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Mississippi to South America

Discover the top 2 airlines that operate flights from Mississippi to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$528Average$658FlexibilityNo cancel feeOn-time69%
DeltaCheapest$583Average$725FlexibilityNo cancel feeOn-timeN/A

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