Premium Business offers lie-flat beds with open suites on select aircraft.
LATAM+ offers more legroom and earlier boarding in economy class.

Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $475 (Booking.com) |
One-way from | $209 (Kiwi.com) |
Popular in | December |
Cheapest in | May |
Average price | $933 |
Good round-trip deal | $639 or less |
Good one-way deal | $389 or less |
Fly from
Fly to
Route
Depart
Return
Price
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Thu 1/1
11:15 am-8:50 am
1 stop16h 35m
Santiago Arturo Merino Benitez
Thu 1/8
10:45 pm-12:20 pm
1 stop18h 35m
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Mon 3/16
1:54 am-12:34 am
1 stop18h 40m
Santiago Arturo Merino Benitez
Mon 3/30
1:49 am-11:40 pm
1 stop25h 51m
BaltimoreSantiago
BWI - SCL
BWISCL
Baltimore/Washington
Tue 2/17
7:15 am-7:40 am
1 stop22h 25m
Santiago Arturo Merino Benitez
Wed 2/25
11:10 pm-11:54 am
1 stop14h 44m
BaltimoreSantiago
BWI - SCL
BWISCL
Baltimore/Washington
Tue 2/17
7:15 am-7:40 am
1 stop22h 25m
Santiago Arturo Merino Benitez
Fri 2/27
11:10 pm-11:54 am
1 stop14h 44m
BaltimoreSantiago
BWI - SCL
BWISCL
Baltimore/Washington
Mon 2/16
7:15 am-7:40 am
1 stop22h 25m
Santiago Arturo Merino Benitez
Mon 3/2
11:10 pm-5:56 pm
1 stop20h 46m
BaltimoreSantiago
BWI - SCL
BWISCL
Baltimore/Washington
Mon 2/16
4:45 pm-7:40 am
1 stop12h 55m
Santiago Arturo Merino Benitez
Sun 3/1
11:10 pm-5:56 pm
1 stop20h 46m
BaltimoreSantiago
BWI - SCL
BWISCL
Baltimore/Washington
Mon 2/16
1:01 pm-7:40 am
1 stop16h 39m
Santiago Arturo Merino Benitez
Wed 2/25
11:10 pm-11:54 am
1 stop14h 44m
BaltimoreSantiago
BWI - SCL
BWISCL
Baltimore/Washington
Tue 2/17
1:01 pm-7:40 am
1 stop16h 39m
Santiago Arturo Merino Benitez
Tue 3/3
11:10 pm-11:54 am
1 stop14h 44m
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Fri 12/26
12:30 am-8:50 am
1 stop27h 20m
Santiago Arturo Merino Benitez
Tue 12/30
10:45 pm-2:51 pm
1 stop21h 06m
Washington, D.C.Santiago
IAD - SCL
IADSCL
Washington, D.C. Dulles Intl
Tue 2/24
3:42 pm-7:40 am
1 stop13h 58m
Santiago Arturo Merino Benitez
Tue 3/10
6:40 am-12:26 am
2 stops18h 46m
Currently, June is the cheapest month in which you can book a flight from USA to Santiago (average of $143). Flying from USA to Santiago in February is currently the most expensive (average of $506). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
It’s typically best to fly out from USA to Santiago in the evening. Doing so could potentially save you 6% on the flight price compared to flying in the afternoon, which is usually more expensive.
Travelers seeking maximum savings on their USA to Santiago flight should consider departing on Saturday evenings when fares are most often at their lowest. Saturday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
The most flights from US0 to SCL are scheduled on a Monday (4 on average). You will have fewer flight options on Friday, which is when the least amount of flights are scheduled (3 on average).
About 23% of weekly flights between United States and Santiago have experienced delays in the past year, with the average delay time being 191 minutes.
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the morning tend to experience delays more often.
Friday tends to have the lowest number of delays on this route, whereas Saturday has historically faced a higher average of delays compared to other days of the week.
Over the last year, Star Peru have had the lowest number of delays on this route, with just 5% of flights being delayed.
Entertainment
Crew
Overall
Food
Boarding
Comfort
Reviews
Jim,Nov 2025
AVL - ATL
Entertainment
Crew
Overall
Food
Boarding
Comfort
Reviews
Jim,Nov 2025
AVL - ATL
Entertainment
Crew
Overall
Food
Boarding
Comfort
Reviews
Jim,Nov 2025
AVL - ATL
Entertainment
Crew
Overall
Food
Boarding
Comfort
Reviews
Jim,Nov 2025
AVL - ATL
Entertainment
Crew
Overall
Food
Boarding
Comfort
Reviews
Jim,Nov 2025
AVL - ATL
Entertainment
Crew
Overall
Food
Boarding
Comfort
Reviews
Jim,Nov 2025
AVL - ATL
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$190 | Average$448 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$222 | Average$661 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$254 | Average$773 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$396 | Average$795 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$463 | Average$867 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$501 | Average$822 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$513 | Average$875 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$650 | Average$729 | FlexibilityNo cancel fee | On-time73% | |
| Cheapest$697 | Average$781 | FlexibilityNo cancel fee | On-time67% | |
| Cheapest$758 | Average$1,048 | FlexibilityNo cancel fee | On-timeN/A |