Premium Business offers lie-flat beds with open suites on select aircraft.
LATAM+ offers more legroom and earlier boarding in economy class.

Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $495 (United Airlines) |
One-way from | $185 (Trip.com) |
Popular in | December |
Cheapest in | May |
Average price | $870 |
Good round-trip deal | $639 or less |
Good one-way deal | $233 or less |
Fly from
Fly to
Route
Depart
Return
Price
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Mon 1/19
5:00 am-8:50 am
1 stop22h 50m
Santiago Arturo Merino Benitez
Wed 2/25
10:45 pm-5:54 pm
1 stop24h 09m
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Wed 2/4
7:00 am-8:15 am
1 stop20h 15m
Santiago Arturo Merino Benitez
Wed 2/11
10:30 pm-3:00 pm
1 stop21h 30m
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Wed 2/4
5:40 am-8:50 am
1 stop22h 10m
Santiago Arturo Merino Benitez
Thu 2/19
10:45 pm-2:57 pm
1 stop21h 12m
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Tue 1/27
8:00 am-9:00 am
1 stop20h 00m
Santiago Arturo Merino Benitez
Tue 3/3
11:15 pm-7:48 pm
1 stop25h 33m
MiamiSantiago
MIA - SCL
MIASCL
Miami
Mon 1/19
5:10 pm-10:15 pm
1 stop27h 05m
Santiago Arturo Merino Benitez
Mon 3/23
1:35 am-8:20 am
2 stops31h 45m
MiamiSantiago
MIA - SCL
MIASCL
Miami
Sat 2/14
5:10 pm-12:15 pm
2 stops17h 05m
Santiago Arturo Merino Benitez
Sat 2/21
5:50 am-3:50 pm
1 stop12h 00m
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Sat 4/4
1:23 am-10:43 pm
1 stop18h 20m
Santiago Arturo Merino Benitez
Wed 4/15
4:17 am-11:40 pm
1 stop22h 23m
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Sun 4/19
1:23 am-2:20 am
1 stop21h 57m
Santiago Arturo Merino Benitez
Sun 5/3
12:38 am-11:40 pm
1 stop26h 02m
MiamiSantiago
MIA - SCL
MIASCL
Miami
Wed 2/4
2:05 am-12:30 am
1 stop20h 25m
Santiago Arturo Merino Benitez
Mon 2/16
9:05 pm-7:20 am
1 stop12h 15m
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Thu 2/5
5:00 am-8:50 am
1 stop22h 50m
Santiago Arturo Merino Benitez
Thu 2/12
10:45 pm-7:04 pm
1 stop25h 19m
Currently, June is the cheapest month in which you can book a flight from USA to Santiago (average of $143). Flying from USA to Santiago in February is currently the most expensive (average of $505). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
It’s typically best to fly out from USA to Santiago in the morning. Doing so could potentially save you 20% on the flight price compared to flying in the afternoon, which is usually more expensive.
The most flights from US0 to SCL are scheduled on a Monday (4 on average). You will have fewer flight options on Friday, which is when the least amount of flights are scheduled (3 on average).
About 23% of weekly flights between United States and Santiago have experienced delays in the past year, with the average delay time being 191 minutes.
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the morning tend to experience delays more often.
Friday tends to have the lowest number of delays on this route, whereas Saturday has historically faced a higher average of delays compared to other days of the week.
Over the last year, Star Peru have had the lowest number of delays on this route, with just 5% of flights being delayed.
Boarding
Comfort
Food
Crew
Entertainment
Overall
Reviews
Jim,Nov 2025
AVL - ATL
Boarding
Comfort
Food
Crew
Entertainment
Overall
Reviews
Jim,Nov 2025
AVL - ATL
Boarding
Comfort
Food
Crew
Entertainment
Overall
Reviews
Jim,Nov 2025
AVL - ATL
Boarding
Comfort
Food
Crew
Entertainment
Overall
Reviews
Jim,Nov 2025
AVL - ATL
Boarding
Comfort
Food
Crew
Entertainment
Overall
Reviews
Jim,Nov 2025
AVL - ATL
Boarding
Comfort
Food
Crew
Entertainment
Overall
Reviews
Jim,Nov 2025
AVL - ATL
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$190 | Average$448 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$219 | Average$661 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$254 | Average$755 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$396 | Average$801 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$463 | Average$849 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$501 | Average$827 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$504 | Average$860 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$557 | Average$793 | FlexibilityNo cancel fee | On-time67% | |
| Cheapest$650 | Average$729 | FlexibilityNo cancel fee | On-time73% | |
| Cheapest$758 | Average$1,148 | FlexibilityNo cancel fee | On-timeN/A |