Premium Business offers lie-flat beds with open suites on select aircraft.
LATAM+ offers more legroom and earlier boarding in economy class.

Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $494 (United Airlines) |
One-way from | $211 (Kiwi.com) |
Popular in | December |
Cheapest in | May |
Average price | $938 |
Good round-trip deal | $661 or less |
Good one-way deal | $294 or less |
Fly from
Fly to
Route
Depart
Return
Price
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Mon 1/19
9:05 am-8:50 am
1 stop18h 45m
Santiago Arturo Merino Benitez
Mon 2/2
10:45 pm-4:50 pm
1 stop23h 05m
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Tue 1/20
1:19 pm-8:50 am
1 stop14h 31m
Santiago Arturo Merino Benitez
Tue 1/27
10:45 pm-9:45 am
1 stop16h 00m
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Tue 1/13
5:00 am-8:50 am
1 stop22h 50m
Santiago Arturo Merino Benitez
Wed 1/28
10:45 pm-12:20 pm
1 stop18h 35m
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Wed 1/14
1:19 pm-8:50 am
1 stop14h 31m
Santiago Arturo Merino Benitez
Mon 1/26
10:45 pm-2:56 pm
1 stop21h 11m
MiamiSantiago
MIA - SCL
MIASCL
Miami
Fri 1/9
5:10 pm-6:40 am
1 stop11h 30m
Santiago Arturo Merino Benitez
Fri 1/30
1:35 am-3:50 pm
2 stops16h 15m
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Sun 5/10
12:05 am-4:15 am
2 stops25h 10m
Santiago Arturo Merino Benitez
Wed 5/20
2:30 pm-10:45 pm
2 stops35h 15m
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Tue 1/20
11:04 am-8:15 am
2 stops16h 11m
Santiago Arturo Merino Benitez
Tue 1/27
10:30 pm-3:05 pm
2 stops21h 35m
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Tue 1/13
1:15 pm-9:00 am
1 stop14h 45m
Santiago Arturo Merino Benitez
Tue 1/27
10:30 pm-3:05 pm
2 stops21h 35m
MiamiSantiago
MIA - SCL
MIASCL
Miami
Wed 3/11
9:40 am-12:00 pm
2 stops25h 20m
Santiago Arturo Merino Benitez
Fri 3/20
1:35 am-8:20 am
2 stops31h 45m
MiamiSantiago
MIA - SCL
MIASCL
Miami
Wed 2/4
8:45 am-12:15 pm
2 stops25h 30m
Santiago Arturo Merino Benitez
Wed 2/18
9:05 pm-7:20 am
1 stop12h 15m
Currently, June is the cheapest month in which you can book a flight from USA to Santiago (average of $143). Flying from USA to Santiago in February is currently the most expensive (average of $506). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
It’s typically best to fly out from USA to Santiago in the evening. Doing so could potentially save you 4% on the flight price compared to flying at noon, which is usually more expensive.
Travelers seeking maximum savings on their USA to Santiago flight should consider departing on Saturday evenings when fares are most often at their lowest. Saturday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
The most flights from US0 to SCL are scheduled on a Monday (4 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (4 on average).
About 23% of weekly flights between United States and Santiago have experienced delays in the past year, with the average delay time being 191 minutes.
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the morning tend to experience delays more often.
Friday tends to have the lowest number of delays on this route, whereas Saturday has historically faced a higher average of delays compared to other days of the week.
Over the last year, Star Peru have had the lowest number of delays on this route, with just 5% of flights being delayed.
Boarding
Food
Comfort
Entertainment
Overall
Crew
Reviews
Jim,Nov 2025
AVL - ATL
Boarding
Food
Comfort
Entertainment
Overall
Crew
Reviews
Jim,Nov 2025
AVL - ATL
Boarding
Food
Comfort
Entertainment
Overall
Crew
Reviews
Jim,Nov 2025
AVL - ATL
Boarding
Food
Comfort
Entertainment
Overall
Crew
Reviews
Jim,Nov 2025
AVL - ATL
Boarding
Food
Comfort
Entertainment
Overall
Crew
Reviews
Jim,Nov 2025
AVL - ATL
Boarding
Food
Comfort
Entertainment
Overall
Crew
Reviews
Jim,Nov 2025
AVL - ATL
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$190 | Average$448 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$221 | Average$661 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$254 | Average$769 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$396 | Average$791 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$463 | Average$854 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$501 | Average$825 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$513 | Average$875 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$650 | Average$729 | FlexibilityNo cancel fee | On-time73% | |
| Cheapest$697 | Average$771 | FlexibilityNo cancel fee | On-time67% | |
| Cheapest$758 | Average$1,048 | FlexibilityNo cancel fee | On-timeN/A |