Premium Business offers lie-flat beds with open suites on select aircraft.
LATAM+ offers more legroom and earlier boarding in economy class.

Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $503 (Kiwi.com) |
One-way from | $210 (eDestinos) |
Popular in | December |
Cheapest in | May |
Average price | $866 |
Good round-trip deal | $655 or less |
Good one-way deal | $233 or less |
Fly from
Fly to
Route
Depart
Return
Price
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Sun 4/12
1:23 am-3:00 am
1 stop22h 37m
Santiago Arturo Merino Benitez
Sun 4/19
12:46 am-11:40 pm
1 stop25h 54m
MiamiSantiago
MIA - SCL
MIASCL
Miami
Thu 2/26
8:45 am-10:15 pm
1 stop11h 30m
Santiago Arturo Merino Benitez
Sun 3/8
1:35 am-4:50 pm
2 stops16h 15m
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Fri 4/17
1:23 am-5:03 am
1 stop24h 40m
Santiago Arturo Merino Benitez
Sat 4/25
4:49 am-11:40 pm
1 stop21h 51m
MiamiSantiago
MIA - SCL
MIASCL
Miami
Sun 2/15
3:02 pm-4:55 am
1 stop11h 53m
Santiago Arturo Merino Benitez
Fri 2/20
1:35 am-7:20 am
2 stops31h 45m
Washington, D.C.Santiago
IAD - SCL
IADSCL
Washington, D.C. Dulles Intl
Mon 4/6
9:39 am-11:00 am
3 stops25h 21m
Santiago Arturo Merino Benitez
Mon 4/13
11:55 pm-2:00 pm
1 stop14h 05m
Washington, D.C.Santiago
IAD - SCL
IADSCL
Washington, D.C. Dulles Intl
Thu 3/12
3:35 pm-3:20 pm
1 stop22h 45m
Santiago Arturo Merino Benitez
Sun 3/22
7:25 am-5:25 am
1 stop23h 00m
Washington, D.C.Santiago
IAD - SCL
IADSCL
Washington, D.C. Dulles Intl
Mon 3/9
5:15 pm-3:20 pm
2 stops21h 05m
Santiago Arturo Merino Benitez
Wed 3/11
1:35 am-2:15 pm
1 stop13h 40m
Washington, D.C.Santiago
IAD - SCL
IADSCL
Washington, D.C. Dulles Intl
Mon 3/2
4:15 pm-12:30 am
2 stops30h 15m
Santiago Arturo Merino Benitez
Sat 3/21
7:25 am-2:40 am
2 stops20h 15m
BostonSantiago
BOS - SCL
BOSSCL
Boston Logan Intl
Wed 3/11
5:50 pm-12:00 pm
3 stops41h 10m
Santiago Arturo Merino Benitez
Tue 3/24
11:25 pm-1:55 pm
1 stop15h 30m
MiamiSantiago
MIA - SCL
MIASCL
Miami
Thu 1/29
12:55 pm-3:35 am
1 stop12h 40m
Santiago Arturo Merino Benitez
Fri 1/30
12:40 am-11:25 am
1 stop12h 45m
Currently, June is the cheapest month in which you can book a flight from USA to Santiago (average of $143). Flying from USA to Santiago in February is currently the most expensive (average of $506). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
It’s typically best to fly out from USA to Santiago in the morning. Doing so could potentially save you 21% on the flight price compared to flying in the afternoon, which is usually more expensive.
The most flights from US0 to SCL are scheduled on a Monday (4 on average). You will have fewer flight options on Friday, which is when the least amount of flights are scheduled (3 on average).
About 24% of weekly flights between United States and Santiago have experienced delays in the past year, with the average delay time being 183 minutes.
Historically, flights departing in the early afternoon are less likely to be delayed, whereas flights leaving in the morning tend to experience delays more often.
Tuesday tends to have the lowest number of delays on this route, whereas Saturday has historically faced a higher average of delays compared to other days of the week.
Over the last year, Wamos Air have had the lowest number of delays on this route, with just 14% of flights being delayed.
Food
Comfort
Crew
Overall
Entertainment
Boarding
Reviews
Jim,Nov 2025
AVL - ATL
Food
Comfort
Crew
Overall
Entertainment
Boarding
Reviews
Jim,Nov 2025
AVL - ATL
Food
Comfort
Crew
Overall
Entertainment
Boarding
Reviews
Jim,Nov 2025
AVL - ATL
Food
Comfort
Crew
Overall
Entertainment
Boarding
Reviews
Jim,Nov 2025
AVL - ATL
Food
Comfort
Crew
Overall
Entertainment
Boarding
Reviews
Jim,Nov 2025
AVL - ATL
Food
Comfort
Crew
Overall
Entertainment
Boarding
Reviews
Jim,Nov 2025
AVL - ATL
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$170 | Average$332 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$212 | Average$653 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$244 | Average$752 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$302 | Average$795 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$397 | Average$826 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$463 | Average$850 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$473 | Average$859 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$557 | Average$808 | FlexibilityNo cancel fee | On-time67% | |
| Cheapest$650 | Average$729 | FlexibilityNo cancel fee | On-time73% | |
| Cheapest$758 | Average$1,147 | FlexibilityNo cancel fee | On-timeN/A |