Premium Business offers lie-flat beds with open suites on select aircraft.
LATAM+ offers more legroom and earlier boarding in economy class.

Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $441 (FlightHub) |
One-way from | $201 (Kiwi.com) |
Popular in | December |
Cheapest in | May |
Average price | $734 |
Good round-trip deal | $639 or less |
Good one-way deal | $353 or less |
Fly from
Fly to
Route
Depart
Return
Price
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Thu 4/16
8:35 pm-11:32 pm
1 stop23h 57m
Santiago Arturo Merino Benitez
Wed 4/29
4:44 am-11:40 pm
1 stop21h 56m
San FranciscoSantiago
SFO - SCL
SFOSCL
San Francisco
Sat 4/11
1:42 am-3:14 am
1 stop22h 32m
Santiago Arturo Merino Benitez
Sun 4/19
4:20 am-6:25 pm
1 stop17h 05m
Washington, D.C.Santiago
IAD - SCL
IADSCL
Washington, D.C. Dulles Intl
Mon 1/5
1:12 am-11:43 pm
1 stop20h 31m
Santiago Arturo Merino Benitez
Wed 1/28
5:44 am-3:13 am
1 stop23h 29m
Washington, D.C.Santiago
IAD - SCL
IADSCL
Washington, D.C. Dulles Intl
Tue 11/25
8:22 am-11:41 pm
1 stop13h 19m
Santiago Arturo Merino Benitez
Tue 12/9
5:44 am-3:22 am
1 stop23h 38m
Washington, D.C.Santiago
IAD - SCL
IADSCL
Washington, D.C. Dulles Intl
Fri 11/28
1:13 am-12:06 am
1 stop20h 53m
Santiago Arturo Merino Benitez
Fri 12/5
12:20 pm-3:22 am
1 stop17h 02m
Washington, D.C.Santiago
IAD - SCL
IADSCL
Washington, D.C. Dulles Intl
Sat 11/22
8:30 am-8:50 am
1 stop22h 20m
Santiago Arturo Merino Benitez
Mon 12/1
10:45 pm-11:23 am
1 stop14h 38m
Washington, D.C.Santiago
IAD - SCL
IADSCL
Washington, D.C. Dulles Intl
Sat 11/29
6:00 am-12:50 pm
2 stops28h 50m
Santiago Arturo Merino Benitez
Wed 12/3
8:15 am-12:12 am
2 stops17h 57m
Washington, D.C.Santiago
IAD - SCL
IADSCL
Washington, D.C. Dulles Intl
Tue 1/6
3:00 pm-7:40 am
1 stop14h 40m
Santiago Arturo Merino Benitez
Wed 1/28
8:15 am-12:24 am
2 stops18h 09m
Washington, D.C.Santiago
IAD - SCL
IADSCL
Washington, D.C. Dulles Intl
Tue 2/3
12:40 pm-7:40 am
1 stop17h 00m
Santiago Arturo Merino Benitez
Tue 2/10
8:15 am-12:24 am
2 stops18h 09m
BaltimoreSantiago
BWI - SCL
BWISCL
Baltimore/Washington
Sun 12/7
3:56 pm-8:50 am
1 stop14h 54m
Santiago Arturo Merino Benitez
Sun 12/14
10:45 pm-4:15 pm
1 stop19h 30m
Currently, June is the cheapest month in which you can book a flight from USA to Santiago (average of $143). Flying from USA to Santiago in February is currently the most expensive (average of $503). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
It’s typically best to fly out from USA to Santiago in the evening. Doing so could potentially save you 7% on the flight price compared to flying in the afternoon, which is usually more expensive.
Travelers seeking maximum savings on their USA to Santiago flight should consider departing on Saturday evenings when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
Crew
Entertainment
Boarding
Comfort
Overall
Food
Reviews
Jim,Nov 2025
AVL - ATL
Crew
Entertainment
Boarding
Comfort
Overall
Food
Reviews
Jim,Nov 2025
AVL - ATL
Crew
Entertainment
Boarding
Comfort
Overall
Food
Reviews
Jim,Nov 2025
AVL - ATL
Crew
Entertainment
Boarding
Comfort
Overall
Food
Reviews
Jim,Nov 2025
AVL - ATL
Crew
Entertainment
Boarding
Comfort
Overall
Food
Reviews
Jim,Nov 2025
AVL - ATL
Crew
Entertainment
Boarding
Comfort
Overall
Food
Reviews
Jim,Nov 2025
AVL - ATL
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$190 | Average$448 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$245 | Average$680 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$254 | Average$779 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$437 | Average$885 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$463 | Average$824 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$463 | Average$862 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$501 | Average$855 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$650 | Average$729 | FlexibilityNo cancel fee | On-time73% | |
| Cheapest$694 | Average$767 | FlexibilityNo cancel fee | On-time67% | |
| Cheapest$758 | Average$1,154 | FlexibilityNo cancel fee | On-timeN/A |