$358+ Cheap flights from Denver (DEN) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/16. Fares are subject to change and may not be available on all flights or dates of travel.
DEN — SCL
May 26 — Jun 21
Round-trip
1 adult, Economy
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Cheapest flights from Denver to SantiagoExplore the most affordable flight options available from Denver to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 26, 2026.
Explore the most affordable flight options available from Denver to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 26, 2026.
This FlightHub deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:30 am
DEN
- SCL
1 stop21h 05m
LATAM Airlines
Fri 8/2111:25 pm
SCL
- DEN
1 stop20h 45m
LATAM Airlines
Deal found 4/25![LATAM Airlines logo]()
$673
This LATAM Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:30 am
DEN
- SCL
1 stop21h 05m
LATAM Airlines
Sun 8/3011:00 pm
SCL
- DEN
2 stops20h 58m
LATAM Airlines
Deal found 4/21![LATAM Airlines logo]()
$694
This FlightHub deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/143:10 pm
DEN
- SCL
2 stops18h 55m
LATAM Airlines
Mon 11/2311:25 pm
SCL
- DEN
1 stop22h 45m
LATAM Airlines
Deal found 4/21![LATAM Airlines logo]()
$704
This Copa Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/510:43 pm
DEN
- SCL
1 stop22h 43m
Copa Airlines
Tue 8/112:56 am
SCL
- DEN
1 stop17h 24m
Copa Airlines
Deal found 4/23![Copa Airlines logo]()
$723
This Justfly.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/67:05 am
DEN
- SCL
2 stops18h 30m
LATAM Airlines
Mon 2/157:45 am
SCL
- DEN
2 stops18h 32m
LATAM Airlines
Deal found 4/23![LATAM Airlines logo]()
$725
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/76:00 am
DEN
- SCL
2 stops22h 00m
Delta
Wed 8/1211:25 pm
SCL
- DEN
1 stop25h 33m
Delta
Deal found 4/25![Delta logo]()
$735
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:39 am
DEN
- SCL
2 stops18h 21m
Delta
Thu 8/1311:00 pm
SCL
- DEN
2 stops20h 58m
Delta
Deal found 4/24![Delta logo]()
$740
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:20 pm
DEN
- SCL
1 stop15h 05m
Delta
Sat 10/108:40 pm
SCL
- DEN
1 stop30h 09m
Delta
Deal found 4/21![Delta logo]()
$741
This BusinessClass deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/811:59 pm
DEN
- SCL
2 stops28h 51m
GOL
Thu 8/138:30 pm
SCL
- DEN
2 stops20h 59m
GOL
Deal found 4/24![GOL logo]()
$742
This Copa Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/510:43 pm
DEN
- SCL
1 stop22h 00m
Copa Airlines
Sat 8/1512:43 am
SCL
- DEN
1 stop19h 37m
Copa Airlines
Deal found 4/23![Copa Airlines logo]()
$746
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/2912:45 pm
DEN
- SCL
1 stop16h 05m
American Airlines
Sat 9/59:30 pm
SCL
- DEN
1 stop27h 31m
American Airlines
Deal found 4/22![American Airlines logo]()
$747
Best flights from Denver to SantiagoDiscover carefully curated flight deals from Denver to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 26, 2026.
Discover carefully curated flight deals from Denver to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 26, 2026.
This Copa Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/510:43 pm
DEN
- SCL
1 stop22h 43m
Copa Airlines
Fri 8/144:14 am
SCL
- DEN
1 stop16h 06m
Copa Airlines
Deal found 4/21![Copa Airlines logo]()
$723
This LATAM Airlines deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/246:30 am
DEN
- SCL
2 stops20h 20m
LATAM Airlines
Fri 8/2811:05 pm
SCL
- DEN
2 stops35h 36m
LATAM Airlines
Deal found 4/25![LATAM Airlines logo]()
$735
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:05 am
DEN
- SCL
1 stop23h 10m
Delta
Sat 10/2411:25 pm
SCL
- DEN
1 stop21h 45m
Delta
Deal found 4/25![Delta logo]()
$735
This Copa Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/510:43 pm
DEN
- SCL
1 stop22h 43m
Copa Airlines
Tue 8/112:27 am
SCL
- DEN
1 stop17h 53m
Copa Airlines
Deal found 4/24![Copa Airlines logo]()
$723
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:45 am
DEN
- SCL
2 stops21h 10m
Delta
Sun 9/2011:25 pm
SCL
- DEN
2 stops18h 46m
Delta
Deal found 4/23![Delta logo]()
$740
This Copa Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2710:43 pm
DEN
- SCL
1 stop22h 43m
Copa Airlines
Mon 8/34:14 am
SCL
- DEN
1 stop16h 06m
Copa Airlines
Deal found 4/21![Copa Airlines logo]()
$723
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:30 am
DEN
- SCL
1 stop21h 05m
Delta
Fri 8/2111:25 pm
SCL
- DEN
2 stops21h 45m
Delta
Deal found 4/25![Delta logo]()
$740
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:20 pm
DEN
- SCL
1 stop15h 05m
Delta
Sat 10/108:40 pm
SCL
- DEN
1 stop30h 09m
Delta
Deal found 4/21![Delta logo]()
$741
This Copa Airlines deal was found by Cheapflights users on 4/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/510:43 pm
DEN
- SCL
1 stop22h 00m
Copa Airlines
Sat 8/1512:06 am
SCL
- DEN
1 stop20h 14m
Copa Airlines
Deal found 4/26![Copa Airlines logo]()
$746
This Copa Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/110:43 pm
DEN
- SCL
1 stop18h 40m
Copa Airlines
Fri 8/142:56 am
SCL
- DEN
1 stop17h 24m
Copa Airlines
Deal found 4/22![Copa Airlines logo]()
$769
This Delta deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/127:15 am
DEN
- SCL
1 stop22h 00m
Delta
Fri 7/178:40 pm
SCL
- DEN
1 stop18h 25m
Delta
Deal found 4/25![Delta logo]()
$845
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/296:00 am
DEN
- SCL
1 stop23h 15m
Delta
Mon 7/138:40 pm
SCL
- DEN
1 stop18h 25m
Delta
Deal found 4/23![Delta logo]()
$845
Last-minute flights from Denver to SantiagoDiscover last-minute flight deals from Denver to Santiago. Data last updated April 26, 2026 and is based on user searches.
Discover last-minute flight deals from Denver to Santiago. Data last updated April 26, 2026 and is based on user searches.
This Copa Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2310:51 pm
DEN
- SCL
1 stop18h 32m
Copa Airlines
Thu 4/304:49 am
SCL
- DEN
1 stop15h 36m
Copa Airlines
Deal found 4/22![Copa Airlines logo]()
$806
This Copa Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/2510:51 pm
DEN
- SCL
1 stop21h 52m
Copa Airlines
Sat 5/24:09 am
SCL
- DEN
1 stop16h 16m
Copa Airlines
Deal found 4/24![Copa Airlines logo]()
$783
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/510:39 pm
DEN
- SCL
1 stop28h 56m
Multiple Airlines
Tue 5/125:00 am
SCL
- DEN
2 stops29h 57m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$829
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:20 am
DEN
- SCL
1 stop20h 15m
Multiple Airlines
Wed 5/135:00 am
SCL
- DEN
2 stops29h 57m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$890
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/67:20 am
DEN
- SCL
1 stop20h 15m
Multiple Airlines
Sun 5/106:40 am
SCL
- DEN
2 stops43h 04m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$912
This Copa Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/710:51 pm
DEN
- SCL
1 stop18h 32m
Copa Airlines
Wed 5/134:09 am
SCL
- DEN
1 stop16h 16m
Copa Airlines
Deal found 4/23![Copa Airlines logo]()
$853
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/77:00 am
DEN
- SCL
1 stop20h 35m
Multiple Airlines
Wed 5/135:00 am
SCL
- DEN
2 stops29h 57m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$916
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:45 pm
DEN
- SCL
2 stops35h 40m
Multiple Airlines
Mon 6/158:20 pm
SCL
- DEN
2 stops38h 17m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$811
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1211:45 pm
DEN
- SCL
2 stops35h 40m
Multiple Airlines
Sun 6/144:56 am
SCL
- DEN
2 stops57h 23m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$828
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/1311:45 pm
DEN
- SCL
1 stop29h 10m
Multiple Airlines
Mon 6/158:20 pm
SCL
- DEN
2 stops38h 17m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$883
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/177:00 am
DEN
- SCL
1 stop20h 35m
Multiple Airlines
Wed 5/278:20 pm
SCL
- DEN
2 stops38h 37m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$884
One-way flights from Denver to SantiagoSearch for one-way flight options from Denver to Santiago. Find affordable one-way fares based on user searches. Data last updated April 26, 2026.
Search for one-way flight options from Denver to Santiago. Find affordable one-way fares based on user searches. Data last updated April 26, 2026.
This Kiwi.com deal was found by Cheapflights users on 4/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/1611:40 pm
DEN
- SCL
2 stops27h 50m
Multiple Airlines
Deal found 4/25![Multiple Airlines logo]()
$358
This Kiwi.com deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:30 am
DEN
- SCL
3 stops42h 05m
Multiple Airlines
Deal found 4/23![Multiple Airlines logo]()
$377
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/611:54 pm
DEN
- SCL
3 stops59h 36m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$379
This Mytrip deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/271:53 pm
DEN
- SCL
3 stops28h 41m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$380
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/411:54 pm
DEN
- SCL
3 stops41h 29m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$411
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/412:56 am
DEN
- SCL
3 stops38h 15m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$412
This Kiwi.com deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/309:25 pm
DEN
- SCL
2 stops29h 20m
Multiple Airlines
Deal found 4/21![Multiple Airlines logo]()
$425
This Kiwi.com deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3012:55 am
DEN
- SCL
2 stops25h 16m
Multiple Airlines
Deal found 4/24![Multiple Airlines logo]()
$426
Find flight deals from Denver to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from Denver (DEN) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 26, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $673 (FlightHub) |
One-way from | $358 (Kiwi.com) |
Popular in | December |
Cheapest in | September |
Average price | $771 |
Cheapflights Fare Finder
Customize your flight search to find flights from Denver to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 26, 2026.
Use the filters below to find and compare flights from Denver to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
DenverSantiago
DEN - SCL
DENSCL
Denver Intl
Wed 8/5
10:43 pm-11:26 pm
1 stop22h 43m
Santiago Arturo Merino Benitez
Fri 8/14
4:14 am-6:20 pm
1 stop16h 06m
$723
DenverSantiago
DEN - SCL
DENSCL
Denver Intl
Wed 8/5
10:43 pm-11:26 pm
1 stop22h 43m
Santiago Arturo Merino Benitez
Tue 8/11
2:27 am-6:20 pm
1 stop17h 53m
$723
DenverSantiago
DEN - SCL
DENSCL
Denver Intl
Mon 7/27
10:43 pm-11:26 pm
1 stop22h 43m
Santiago Arturo Merino Benitez
Mon 8/3
4:14 am-6:20 pm
1 stop16h 06m
$723
DenverSantiago
DEN - SCL
DENSCL
Denver Intl
Mon 8/24
6:30 am-4:50 am
2 stops20h 20m
Santiago Arturo Merino Benitez
Fri 8/28
11:05 pm-8:41 am
2 stops35h 36m
$735
DenverSantiago
DEN - SCL
DENSCL
Denver Intl
Mon 10/19
6:05 am-8:15 am
1 stop23h 10m
Santiago Arturo Merino Benitez
Sat 10/24
11:25 pm-6:10 pm
1 stop21h 45m
$735
DenverSantiago
DEN - SCL
DENSCL
Denver Intl
Sat 9/12
6:45 am-6:55 am
2 stops21h 10m
Santiago Arturo Merino Benitez
Sun 9/20
11:25 pm-3:11 pm
2 stops18h 46m
$740
DenverSantiago
DEN - SCL
DENSCL
Denver Intl
Sat 8/15
6:30 am-5:35 am
1 stop21h 05m
Santiago Arturo Merino Benitez
Fri 8/21
11:25 pm-7:10 pm
2 stops21h 45m
$740
DenverSantiago
DEN - SCL
DENSCL
Denver Intl
Sat 10/3
12:20 pm-6:25 am
1 stop15h 05m
Santiago Arturo Merino Benitez
Sat 10/10
8:40 pm-11:49 pm
1 stop30h 09m
$741
DenverSantiago
DEN - SCL
DENSCL
Denver Intl
Wed 8/5
10:43 pm-10:43 pm
1 stop22h 00m
Santiago Arturo Merino Benitez
Sat 8/15
12:06 am-6:20 pm
1 stop20h 14m
$746
Quickest round-trip
DenverSantiago
DEN - SCL
DENSCL
Denver Intl
Sat 8/1
10:43 pm-7:23 pm
1 stop18h 40m
Santiago Arturo Merino Benitez
Fri 8/14
2:56 am-6:20 pm
1 stop17h 24m
$769
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Denver to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Denver to Santiago in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*2 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Denver-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Denver-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Denver-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Denver-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Denver-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Denver to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from Denver with our price prediction graph.
DEN-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Denver to Santiago
How far ahead should I book a flight from Denver to Santiago?
The price you pay for your flight from Denver to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 62 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Denver to Santiago?
Currently, September is the cheapest month in which you can book a flight from Denver to Santiago (average of $681). Flying from Denver to Santiago in December is currently the most expensive (average of $999). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Denver to Santiago?
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated April 26, 2026.
Read reviews from past customers who have flown Delta,Copa Airlines, andLATAM Airlines from Denver to Santiago. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.2
Comfort
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Comfort
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Comfort
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Comfort
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Comfort
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Food
7.2
Comfort
7.9
Boarding
8.1
Crew
8.5
Entertainment
7.8
Overall
7.9
Reviews
1 / 20
6.0
GoodJim,Nov 2025
AVL - ATL
Related info for your journey
Find useful and relevant information for your journey from Denver to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Denver to Santiago
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Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Denver to Santiago by cabin class
Find flights from Denver to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Denver and Santiago flights
Browse other Denver and Santiago flight options. Last updated on April 26, 2026.
Other flights from Denver
Browse through other flights departing from Denver. Flights are based on user searches made on Cheapflights and were last updated on April 26, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 26, 2026.
Top 5 airlines flying from Denver to Santiago
Discover the top 5 airlines that operate flights from Denver to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 26, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$369 | Average$713 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$537 | Average$750 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$544 | Average$774 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$551 | Average$830 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$608 | Average$851 | FlexibilityNo cancel fee | On-time71% |