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$316+ Cheap flights from Mexico City (MEX) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/25. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
Aug 27 — Sep 31
Thu 8/27
Thu 9/3
1 adult, Economy
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Cheapflights Tip: The best prices from Mexico City Benito Juarez to Santiago Arturo Merino Benitez are usually found in November or January, booked 60 days in advance, depart on a Thursday or Saturday and return on a Monday

Cheap flight deals from Mexico City to Santiago

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 28, 2026.

This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1110:00 pm
MEX
-
SCL
2 stops20h 34m
Multiple Airlines
Tue 9/1512:02 pm
SCL
-
MEX
2 stops26h 08m
Multiple Airlines
Deal found 7/28$632
This Kiwi.com deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/251:10 pm
MEX
-
SCL
3 stops19h 39m
Multiple Airlines
Tue 9/18:20 pm
SCL
-
MEX
1 stop16h 50m
Multiple Airlines
Deal found 7/28$635
This Kiwi.com deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3110:00 pm
MEX
-
SCL
1 stop11h 40m
Multiple Airlines
Wed 12/210:12 pm
SCL
-
MEX
1 stop15h 58m
Multiple Airlines
Deal found 7/27$641
This Mytrip deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/1310:00 pm
MEX
-
SCL
1 stop21h 05m
Multiple Airlines
Fri 9/185:57 am
SCL
-
MEX
2 stops33h 13m
Multiple Airlines
Deal found 7/24$643
This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/106:45 am
MEX
-
SCL
2 stops17h 50m
Multiple Airlines
Tue 9/159:20 pm
SCL
-
MEX
1 stop16h 50m
Multiple Airlines
Deal found 7/28$644
This Mytrip deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2110:00 pm
MEX
-
SCL
2 stops28h 45m
Multiple Airlines
Mon 12/1410:12 pm
SCL
-
MEX
1 stop15h 58m
Multiple Airlines
Deal found 7/27$646
This Mytrip deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2410:00 pm
MEX
-
SCL
2 stops23h 20m
Multiple Airlines
Mon 8/318:20 pm
SCL
-
MEX
1 stop16h 50m
Multiple Airlines
Deal found 7/26$647
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2810:00 pm
MEX
-
SCL
1 stop13h 35m
Multiple Airlines
Mon 11/168:35 pm
SCL
-
MEX
1 stop17h 35m
Multiple Airlines
Deal found 7/26$652
This Kiwi.com deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2810:00 pm
MEX
-
SCL
1 stop13h 35m
Multiple Airlines
Wed 11/118:35 pm
SCL
-
MEX
1 stop17h 35m
Multiple Airlines
Deal found 7/26$653
This Mytrip deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/214:55 am
MEX
-
SCL
2 stops20h 58m
Multiple Airlines
Tue 9/229:20 pm
SCL
-
MEX
1 stop16h 50m
Multiple Airlines
Deal found 7/28$657
This Mytrip deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/2410:00 pm
MEX
-
SCL
1 stop21h 05m
Multiple Airlines
Sun 10/41:33 pm
SCL
-
MEX
2 stops24h 22m
Multiple Airlines
Deal found 7/23$660

Find flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$635
(Mytrip)

One-way from

$316
(Kiwi.com)

Popular in

July

Cheapest in

November

Average price

$775

Good round-trip deal

$764 or less

Good one-way deal

$616 or less
Provider with most accurate pricing for Mexico City Benito Juarez-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Mexico City Benito Juarez-Santiago Arturo Merino Benitez flights.
Search Deals
From Mexico City Benito Juarez to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($64 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals
Price to beat on a round-trip flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
Search Deals
Price to beat on a one-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2026.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sat 8/22

3:15 pm-9:10 pm

1 stop27h 55m

Santiago Arturo Merino Benitez

Tue 9/1

8:30 am-3:45 pm

Nonstop9h 15m

$737

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 10/26

1:20 am-3:42 am

1 stop23h 22m

Santiago Arturo Merino Benitez

Sun 11/1

12:15 pm-1:00 am

1 stop15h 45m

$756

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 8/9

2:10 am-1:50 am

1 stop21h 40m

Santiago Arturo Merino Benitez

Wed 5/19

11:30 am-10:05 pm

1 stop12h 35m

$756

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 8/16

2:10 am-10:43 pm

1 stop18h 33m

Santiago Arturo Merino Benitez

Wed 8/26

12:06 am-7:05 pm

1 stop20h 59m

$756
Quickest round-trip

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 12/10

3:25 am-12:18 am

1 stop17h 53m

Santiago Arturo Merino Benitez

Mon 2/8

12:26 pm-10:25 pm

1 stop12h 59m

$777
Cheapest one-way

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 9/23

9:50 am-2:46 am

1 stop13h 56m

$377
Quickest one-way

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Sun 11/15

9:10 am-12:19 am

1 stop12h 09m

$377

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 12/16

3:25 am-3:43 am

1 stop21h 18m

$377

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 8/31

2:10 am-2:56 am

1 stop22h 46m

$377

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 8/12

2:10 am-5:14 am

1 stop25h 04m

$377

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/27

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

Compare providers for flights from Mexico City to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Mexico City to Santiago in July.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
CheapflightsfaresPrice Accuracy2 starsTrust Score*1 star
GotogatePrice Accuracy2 starsTrust Score*3 stars
eDreamsPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Mexico City-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Mexico City-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Mexico City-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Mexico City-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Mexico City-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

The best time to book flights from Mexico City to Santiago is 59 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, November is the cheapest month in which you can book a flight from Mexico City to Santiago (average of $586). Flying from Mexico City to Santiago in July is currently the most expensive (average of $775). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 28, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mexico City to Santiago as you normally would.

How much does it cost to fly round-trip from Mexico City to Santiago?

Airfare is typical for this route at the moment.

Mexico City to Santiago flights typically cost between $599 and $791 in September.
The cheapest round-trip price found within the last 5 days was $632 on Multiple Airlines (Sep 11-Sep 15).

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated July 28, 2026.
See what other customers who have flown with Copa Airlines,LATAM Airlines, andAeromexico from Mexico City to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,559 reviews

Crew

8.1

Boarding

7.8

Food

6.9

Comfort

7.4

Overall

7.6

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Anonymous,Jul 2026

BOS - PTY

Airline was delayed 1 hour, that made my layover flight be missed, gave wrong information about gates, they closed the gates in my face, rebooked me, and had business class, and rebooked me not business class
Copa Airlines
7.6
Good
1,559 reviews
Copa Airlines
7.6
Good
1,559 reviews

Crew

8.1

Boarding

7.8

Food

6.9

Comfort

7.4

Overall

7.6

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Anonymous,Jul 2026

BOS - PTY

Airline was delayed 1 hour, that made my layover flight be missed, gave wrong information about gates, they closed the gates in my face, rebooked me, and had business class, and rebooked me not business class
LATAM Airlines
7.4
Good
1,967 reviews
Copa Airlines
7.6
Good
1,559 reviews

Crew

8.1

Boarding

7.8

Food

6.9

Comfort

7.4

Overall

7.6

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Anonymous,Jul 2026

BOS - PTY

Airline was delayed 1 hour, that made my layover flight be missed, gave wrong information about gates, they closed the gates in my face, rebooked me, and had business class, and rebooked me not business class
Aeromexico
7.4
Good
1,469 reviews
Copa Airlines
7.6
Good
1,559 reviews

Crew

8.1

Boarding

7.8

Food

6.9

Comfort

7.4

Overall

7.6

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Anonymous,Jul 2026

BOS - PTY

Airline was delayed 1 hour, that made my layover flight be missed, gave wrong information about gates, they closed the gates in my face, rebooked me, and had business class, and rebooked me not business class

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Mexico City to Santiago?

    If you wish to fly to Santiago from Mexico City, then you need to book flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez. There is 1 flight from Mexico City (MEX) to Arturo Merino Benitez (SCL) per day to choose from. Flights to Santiago from Mexico City are available from 3 different airlines, which means you should have some options if you want to compare airfare deals. 8h 20m is how long a nonstop flight from Mexico City to Santiago Arturo Merino Benitez typically takes.

  • How popular is this Mexico City to Santiago flight route?

    Within the past month, 4 users have taken a look at flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.

  • What are the cheapest airlines flying from Mexico City to Santiago round-trip?

    Cheapflights users have booked flights from Mexico City to Santiago round-trip from $284. Other airlines that can offer you cheap pricing are Copa Airlines, from $423, and LATAM Airlines, from $465. Users have found that Aeromexico is 58% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Mexico City to Santiago one-way?

    To fly one-way, consider booking your trip with Aeromexico, which is currently one of the cheapest options available, starting at $76. Arajet flights start at $208 while deals on Avianca start at $253 one-way.

  • What are the cheapest flights from Mexico City to Santiago?

    While on average a flight from Mexico City to Santiago is generally $765, our data shows the cheapest flight currently is $389. When looking at the most popular route, (Mexico City Benito Juarez - Santiago Arturo Merino Benitez), you can expect to pay $543 for that flight.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, November is the cheapest month in which you can book a flight from Mexico City to Santiago (average of $586). Flying from Mexico City to Santiago in July is currently the most expensive (average of $775). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Santiago car rentals
Santiago Arturo Merino Benitez Airport car rentals
Lastarria car rentals

Top 3 airlines flying from Mexico City to Santiago

Discover the top 3 airlines that operate flights from Mexico City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
AeromexicoCheapest$284Average$548FlexibilityNo cancel feeOn-timeN/A
Copa AirlinesCheapest$423Average$683FlexibilityNo cancel feeOn-time70%
LATAM AirlinesCheapest$465Average$728FlexibilityNo cancel feeOn-time81%

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