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$374+ Cheap flights from Mexico City (MEX) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/16. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
Jul 11 — Jul 181
Sat 7/11
Sat 7/18
1 adult, Economy
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Cheapflights Tip: The best prices from Mexico City Benito Juarez to Santiago Arturo Merino Benitez are usually found in November or January, booked 90 days in advance, depart on a Thursday or Monday and return on a Monday

Cheap flight deals from Mexico City to Santiago

Cheapest flights from Mexico City to Santiago
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 11, 2026.

This Mytrip deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/2711:20 pm
MEX
-
SCL
2 stops26h 51m
Multiple Airlines
Sun 9/65:56 am
SCL
-
MEX
2 stops33h 14m
Multiple Airlines
Deal found 6/9$699
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/39:50 am
MEX
-
SCL
1 stop14h 00m
Copa Airlines
Sun 8/162:14 am
SCL
-
MEX
1 stop11h 56m
Copa Airlines
Deal found 6/7$705
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/39:50 am
MEX
-
SCL
1 stop14h 00m
Multiple Airlines
Mon 8/174:56 am
SCL
-
MEX
2 stops33h 14m
Multiple Airlines
Deal found 6/7$717
This Copa Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:50 am
MEX
-
SCL
1 stop11h 46m
Copa Airlines
Mon 8/314:14 am
SCL
-
MEX
1 stop12h 16m
Copa Airlines
Deal found 6/8$722
This Mytrip deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/228:40 am
MEX
-
SCL
2 stops17h 16m
Multiple Airlines
Tue 9/295:41 am
SCL
-
MEX
2 stops29h 39m
Multiple Airlines
Deal found 6/6$724
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/83:30 pm
MEX
-
SCL
1 stop11h 44m
Copa Airlines
Wed 7/1511:22 am
SCL
-
MEX
1 stop12h 43m
Copa Airlines
Deal found 6/11$727
This Mytrip deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/84:55 pm
MEX
-
SCL
2 stops18h 40m
Multiple Airlines
Wed 7/152:50 pm
SCL
-
MEX
2 stops34h 10m
Multiple Airlines
Deal found 6/10$728
This Mytrip deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/911:20 pm
MEX
-
SCL
2 stops26h 51m
Multiple Airlines
Wed 7/154:41 am
SCL
-
MEX
2 stops24h 24m
Multiple Airlines
Deal found 6/8$731
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/93:30 pm
MEX
-
SCL
1 stop26h 06m
Copa Airlines
Tue 7/1412:43 am
SCL
-
MEX
1 stop13h 27m
Copa Airlines
Deal found 6/8$736
This Copa Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/289:25 am
MEX
-
SCL
1 stop11h 54m
Copa Airlines
Fri 12/43:19 am
SCL
-
MEX
1 stop21h 41m
Copa Airlines
Deal found 6/8$739

Find flight deals from Mexico City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 11, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$699
(Mytrip)

One-way from

$374
(FlightHub)

Popular in

June

Cheapest in

November

Average price

$768

Good round-trip deal

$728 or less

Good one-way deal

$941 or less
Provider with most accurate pricing for Mexico City Benito Juarez-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Mexico City Benito Juarez-Santiago Arturo Merino Benitez flights.
Search Deals
From Mexico City Benito Juarez to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($71 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
Search Deals
Price to beat on a round-trip flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
Search Deals
Price to beat on a one-way flight from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 11, 2026.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 8/20

9:50 am-2:20 am

1 stop14h 30m

Santiago Arturo Merino Benitez

Tue 9/29

3:14 am-12:10 pm

1 stop11h 56m

$722
Quickest round-trip

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Thu 8/6

9:50 am-11:26 pm

1 stop11h 36m

Santiago Arturo Merino Benitez

Tue 9/22

5:14 am-2:30 pm

1 stop12h 16m

$722

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Mon 8/17

5:50 am-2:20 am

1 stop18h 30m

Santiago Arturo Merino Benitez

Thu 8/27

4:14 am-2:30 pm

1 stop12h 16m

$722

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 8/19

5:50 am-10:43 pm

1 stop14h 53m

Santiago Arturo Merino Benitez

Tue 9/22

3:14 am-2:30 pm

1 stop14h 16m

$722

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 9/2

2:10 am-2:56 am

1 stop22h 46m

Santiago Arturo Merino Benitez

Mon 9/14

3:56 am-12:15 am

1 stop23h 19m

$743

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 7/8

2:10 am-10:43 pm

1 stop18h 33m

Santiago Arturo Merino Benitez

Thu 7/16

11:22 am-10:05 pm

1 stop12h 43m

$756

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Wed 7/8

2:10 am-7:36 pm

1 stop15h 26m

Santiago Arturo Merino Benitez

Thu 7/16

2:56 am-2:30 pm

1 stop13h 34m

$756

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 6/30

12:25 am-3:00 am

1 stop24h 35m

Santiago Arturo Merino Benitez

Sat 7/11

11:22 am-12:15 am

1 stop14h 53m

$777

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Fri 7/3

1:20 am-10:43 pm

1 stop19h 23m

Santiago Arturo Merino Benitez

Sat 7/11

11:22 am-12:15 am

1 stop14h 53m

$777
Cheapest one-way

Mexico CitySantiago

MEX - SCL

MEXSCL

Mexico City Benito Juarez

Tue 6/23

2:10 am-11:26 pm

1 stop19h 16m

$377

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Showing 1-10 of 17 resultsSorted by cheapest first
1
2

Compare providers for flights from Mexico City to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Mexico City to Santiago in June.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
CheapflightsfaresPrice Accuracy2 starsTrust Score*1 star
GotogatePrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Mexico City-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Mexico City-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Mexico City-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Mexico City-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Mexico City-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Mexico City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mexico City to Santiago

How far ahead should I book a flight from Mexico City to Santiago?

The best time to book flights from Mexico City to Santiago is 89 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Mexico City to Santiago?

Currently, November is the cheapest month in which you can book a flight from Mexico City to Santiago (average of $573). Flying from Mexico City to Santiago in June is currently the most expensive (average of $768). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MEX to SCL?

Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 11, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mexico City to Santiago as you normally would.

How much does it cost to fly round-trip from Mexico City to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated June 11, 2026.
See what other customers who have flown with Copa Airlines,LATAM Airlines, andAeromexico from Mexico City to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,569 reviews

Overall

7.5

Food

6.9

Boarding

7.7

Comfort

7.4

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Copa Airlines
7.5
Good
1,569 reviews
Copa Airlines
7.5
Good
1,569 reviews

Overall

7.5

Food

6.9

Boarding

7.7

Comfort

7.4

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
LATAM Airlines
7.4
Good
1,931 reviews
Copa Airlines
7.5
Good
1,569 reviews

Overall

7.5

Food

6.9

Boarding

7.7

Comfort

7.4

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.
Aeromexico
7.4
Good
1,489 reviews
Copa Airlines
7.5
Good
1,569 reviews

Overall

7.5

Food

6.9

Boarding

7.7

Comfort

7.4

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
2.0
Mediocre

Katerine,Mar 2026

LAX - PTY

Really i was expecting be more friendly with family’s, more when you travel with a infant. We expected like a priority to boarding or be friendly with the spots on the aeroplane.

Related info for your journey

Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Mexico City to Santiago?

    If you wish to fly to Santiago from Mexico City, then you need to book flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez. There is 1 flight from Benito Juarez (MEX) to Arturo Merino Benitez (SCL) per day to choose from. Flights to Santiago from Benito Juarez are available from 3 different airlines, which means you should have some options if you want to compare airfare deals. 7h 00m is how long a nonstop flight from Mexico City to Santiago Arturo Merino Benitez typically takes.

  • How popular is this Mexico City to Santiago flight route?

    Within the past month, 4 users have taken a look at flights from Mexico City Benito Juarez to Santiago Arturo Merino Benitez.

  • How long is the flight from Mexico City to Santiago?

    For as low as $722, Copa Airlines can have you in Santiago from Mexico City in 14h 30m. The distance between Mexico City and Santiago is about 4096 mi.

  • What are the cheapest airlines flying from Mexico City to Santiago round-trip?

    Cheapflights users have booked flights from Mexico City to Santiago round-trip from $284. Other airlines that can offer you cheap pricing are LATAM Airlines, from $329, and Copa Airlines, from $423. Users have found that Aeromexico is 57% cheaper than the other options available to this destination.

  • What are the cheapest airlines to fly from Mexico City to Santiago one-way?

    To fly one-way, consider booking your trip with Aeromexico, which is currently one of the cheapest options available, starting at $76. Avianca flights start at $272 while deals on LATAM Airlines start at $283 one-way.

  • What are the cheapest flights from Mexico City to Santiago?

    While on average a flight from Mexico City to Santiago is generally $891, our data shows the cheapest flight currently is $600. When looking at the most popular route, (Mexico City Benito Juarez - Santiago Arturo Merino Benitez), you can expect to pay $718 for that flight.

  • Can I find deals for flights from Mexico City to Santiago that include hotel bookings?

    Yes. In addition to deals on Mexico City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mexico City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mexico City to Santiago.

  • Can I find deals for business class flights from Mexico City to Santiago?

    Yes. Cheapflights offers flight deals from Mexico City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mexico City to Santiago?

    Currently, November is the cheapest month in which you can book a flight from Mexico City to Santiago (average of $573). Flying from Mexico City to Santiago in June is currently the most expensive (average of $768). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Santiago car rentals
Santiago Arturo Merino Benitez Airport car rentals
Lastarria car rentals

Top 3 airlines flying from Mexico City to Santiago

Discover the top 3 airlines that operate flights from Mexico City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
AeromexicoCheapest$284Average$611FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$329Average$721FlexibilityNo cancel feeOn-time81%
Copa AirlinesCheapest$423Average$646FlexibilityNo cancel feeOn-time70%

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