$352+ Cheap flights from Mexico City (MEX) to Santiago (SCL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/1. Fares are subject to change and may not be available on all flights or dates of travel.
MEX — SCL
Oct 10 — Oct 171
Round-trip
1 adult, Economy
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Find cheap flights from Mexico City to Santiago with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Mexico City Benito Juarez to Santiago Arturo Merino Benitez are usually found in January or March, booked 60 days in advance, depart on a Thursday or Tuesday and return on a Monday
Cheap flight deals from Mexico City to Santiago
Cheapest
Best
Last-minute
One-way
Cheapest flights from Mexico City to SantiagoExplore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
Explore the most affordable flight options available from Mexico City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/247:50 pm -
Nonstop8h 10m
Sun 1/109:02 pm -
1 stop17h 08m
Deal found 9/8![Multiple Airlines logo]()
$612
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/1410:00 pm -
1 stop20h 03m
Wed 1/139:02 pm -
1 stop17h 08m
Deal found 9/5![Multiple Airlines logo]()
$628
This LATAM Airlines deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/17:50 pm -
Nonstop8h 10m
Tue 1/268:25 pm -
1 stop20h 25m
Deal found 9/7![LATAM Airlines logo]()
$635
This LATAM Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/126:40 pm -
1 stop18h 08m
Thu 11/269:55 pm -
1 stop18h 55m
Deal found 9/8![Multiple Airlines logo]()
$636
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1210:00 pm -
1 stop11h 40m
Wed 1/139:02 pm -
1 stop17h 08m
Deal found 9/5![Multiple Airlines logo]()
$638
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1310:00 pm -
1 stop20h 03m
Wed 1/139:02 pm -
1 stop17h 08m
Deal found 9/5![Multiple Airlines logo]()
$640
This Kiwi.com deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1510:00 pm -
1 stop20h 03m
Wed 1/139:02 pm -
1 stop17h 08m
Deal found 9/5![Multiple Airlines logo]()
$641
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/247:50 pm -
Nonstop8h 10m
Wed 1/69:02 pm -
1 stop17h 08m
Deal found 9/9![Multiple Airlines logo]()
$646
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/247:50 pm -
Nonstop8h 10m
Sat 1/96:07 am -
1 stop32h 03m
Deal found 9/8![Multiple Airlines logo]()
$647
This Kiwi.com deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2510:00 pm -
1 stop11h 40m
Mon 11/308:35 pm -
1 stop17h 35m
Deal found 9/9![Multiple Airlines logo]()
$648
This LATAM Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/227:50 pm -
Nonstop8h 10m
Thu 12/39:35 am -
Nonstop8h 40m
Deal found 9/9![LATAM Airlines logo]()
$650
This LATAM Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:01 am -
1 stop11h 47m
Fri 11/69:55 pm -
1 stop18h 55m
Deal found 9/9![Multiple Airlines logo]()
$651
Best flights from Mexico City to SantiagoDiscover carefully curated flight deals from Mexico City to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
Discover carefully curated flight deals from Mexico City to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 10, 2026.
This LATAM Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/17:50 pm -
Nonstop8h 10m
Tue 1/269:35 am -
Nonstop8h 40m
Deal found 9/9![LATAM Airlines logo]()
$635
This Copa Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/235:50 am -
1 stop19h 06m
Wed 10/1412:23 pm -
1 stop15h 37m
Deal found 9/6![Copa Airlines logo]()
$768
This LATAM Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/310:00 pm -
1 stop21h 10m
Sat 10/109:30 am -
Nonstop9h 15m
Deal found 9/9![Multiple Airlines logo]()
$787
This Copa Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/312:25 am -
1 stop20h 14m
Sat 10/103:15 am -
1 stop24h 45m
Deal found 9/5![Copa Airlines logo]()
$783
This LATAM Airlines deal was found by Cheapflights users on 9/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/310:00 pm -
1 stop21h 10m
Sun 10/116:00 am -
1 stop35h 55m
Deal found 9/5![Multiple Airlines logo]()
$797
This Copa Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/82:10 am -
1 stop22h 46m
Fri 10/2312:23 pm -
1 stop15h 37m
Deal found 9/9![Copa Airlines logo]()
$783
This Copa Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/11:20 am -
1 stop16h 12m
Sat 10/103:15 am -
1 stop24h 45m
Deal found 9/6![Copa Airlines logo]()
$799
This Copa Airlines deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:20 am -
1 stop23h 18m
Wed 11/43:19 am -
1 stop21h 46m
Deal found 9/8![Copa Airlines logo]()
$809
Last-minute flights from Mexico City to SantiagoDiscover last-minute flight deals from Mexico City to Santiago. Data last updated September 10, 2026 and is based on user searches.
Discover last-minute flight deals from Mexico City to Santiago. Data last updated September 10, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/227:45 pm -
2 stops21h 47m
Thu 11/58:35 pm -
1 stop17h 35m
Deal found 9/8![Multiple Airlines logo]()
$682
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/227:45 pm -
2 stops21h 47m
Fri 11/68:35 pm -
1 stop17h 35m
Deal found 9/8![Multiple Airlines logo]()
$684
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/227:45 pm -
2 stops21h 47m
Mon 11/28:35 pm -
1 stop17h 35m
Deal found 9/8![Multiple Airlines logo]()
$693
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/227:45 pm -
2 stops21h 47m
Tue 11/38:35 pm -
1 stop17h 35m
Deal found 9/8![Multiple Airlines logo]()
$695
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:15 am -
2 stops15h 31m
Wed 11/48:35 pm -
1 stop17h 35m
Deal found 9/8![Multiple Airlines logo]()
$706
This LATAM Airlines deal was found by Cheapflights users on 9/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/68:05 pm -
Nonstop8h 50m
Tue 10/139:30 am -
Nonstop9h 15m
Deal found 9/6![LATAM Airlines logo]()
$708
This LATAM Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:15 pm -
1 stop15h 00m
Thu 11/59:55 pm -
1 stop18h 55m
Deal found 9/9![LATAM Airlines logo]()
$635
This LATAM Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/291:01 am -
1 stop11h 47m
Fri 11/69:55 pm -
1 stop18h 55m
Deal found 9/9![Multiple Airlines logo]()
$651
This FlightHub deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:50 am -
1 stop33h 00m
Thu 11/511:25 pm -
Nonstop8h 45m
Deal found 9/7![Multiple Airlines logo]()
$692
This LATAM Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:50 pm -
Nonstop8h 10m
Fri 11/68:25 pm -
1 stop20h 25m
Deal found 9/9![LATAM Airlines logo]()
$650
This LATAM Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/317:50 pm -
Nonstop8h 10m
Sun 11/89:55 pm -
1 stop18h 55m
Deal found 9/9![LATAM Airlines logo]()
$666
One-way flights from Mexico City to SantiagoSearch for one-way flight options from Mexico City to Santiago. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
Search for one-way flight options from Mexico City to Santiago. Find affordable one-way fares based on user searches. Data last updated September 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/110:00 pm -
1 stop28h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$352
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2010:00 pm -
1 stop28h 13m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$357
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/410:00 pm -
1 stop11h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$370
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:55 pm -
2 stops31h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$373
This Kiwi.com deal was found by Cheapflights users on 9/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/210:10 pm -
3 stops44h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/7![Multiple Airlines logo]()
$374
This Cheapflightsfares deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/269:55 am -
Nonstop8h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Aeromexico logo]()
$375
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/86:45 am -
2 stops19h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$376
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2811:05 pm -
2 stops26h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$377
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/3010:00 pm -
1 stop20h 03m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$379
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/99:05 pm -
2 stops27h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$382
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2710:50 pm -
3 stops34h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$383
This Kiwi.com deal was found by Cheapflights users on 9/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:45 am -
2 stops19h 10m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/8![Multiple Airlines logo]()
$388
Find flight deals from Mexico City to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from Mexico City (MEX) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $596 (LATAM Airlines) |
One-way from | $352 (Kiwi.com) |
Popular in | July |
Cheapest in | January |
Average price | $713 |
Good round-trip deal | $659 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Mexico City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
Use the filters below to find and compare flights from Mexico City to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Mexico CitySantiago
MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez
MEXSCL
Mexico City Benito Juarez
Wed 1/6
4:00 pm-9:05 am
2 stops14h 05m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$377
Mexico CitySantiago
MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez
MEXSCL
Mexico City Benito Juarez
Sat 10/24
1:20 am-12:22 am
1 stop20h 02m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$393
Mexico CitySantiago
MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez
MEXSCL
Mexico City Benito Juarez
Tue 10/6
5:00 pm-8:32 pm
2 stops24h 32m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$393
Mexico CitySantiago
MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez
MEXSCL
Mexico City Benito Juarez
Sat 11/14
10:00 pm-5:03 am
1 stop28h 03m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$398
Mexico CitySantiago
MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez
MEXSCL
Mexico City Benito Juarez
Thu 12/17
6:45 am-3:43 am
2 stops17h 58m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$556
Mexico CitySantiago
MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez
MEXSCL
Mexico City Benito Juarez
Sat 11/28
9:55 am-9:15 pm
Nonstop8h 20m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$580
Mexico CitySantiago
MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez
MEXSCL
Mexico City Benito Juarez
Fri 11/20
8:50 am-8:48 pm
1 stop32h 58m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$616
Quickest round-trip
Mexico CitySantiago
MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez
MEXSCL
Mexico City Benito Juarez
Mon 12/14
7:50 pm-7:00 am
Nonstop8h 10m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$622
Mexico CitySantiago
MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez
MEXSCL
Mexico City Benito Juarez
Sat 9/26
1:20 am-11:39 pm
1 stop19h 19m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$624
Mexico CitySantiago
MEX Mexico City Benito Juarez - SCL Santiago Arturo Merino Benitez
MEXSCL
Mexico City Benito Juarez
Fri 9/25
1:20 am-12:22 am
1 stop20h 02m
Santiago Arturo Merino Benitez
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$624
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from Mexico City to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Mexico City to Santiago in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*1 star | |
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Mexico City-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Mexico City-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Mexico City-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Mexico City-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Mexico City-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Mexico City to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from Mexico City with our price prediction graph.
MEX-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mexico City to Santiago
Prices
Airlines
Delays
How far ahead should I book a flight from Mexico City to Santiago?
The best time to book flights from Mexico City to Santiago is 59 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Mexico City to Santiago?
Currently, January is the cheapest month in which you can book a flight from Mexico City to Santiago (average of $605). Flying from Mexico City to Santiago in July is currently the most expensive (average of $773). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MEX to SCL?
Find hourly flight availability from Mexico City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 10, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Mexico City to Santiago as you normally would.
How often are flights from Mexico City to Santiago delayed?
About 6% of weekly flights between Mexico City and Santiago have experienced delays in the past year, with the average delay time being 147 minutes.
What is the most punctual flight time for Mexico City to Santiago flights?
Historically, flights departing in the early afternoon are less likely to be delayed, whereas flights leaving in the morning tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Wednesday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Mexico City to Santiago flights?
Over the last year, Wamos Air have had the lowest number of delays on this route, with just 5% of flights being delayed.
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated September 10, 2026.
See what other customers who have flown with Copa Airlines,LATAM Airlines, andAeromexico from Mexico City to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
7.6
Crew
8.1
Boarding
7.8
Comfort
7.4
Entertainment
6.9
Food
6.9
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2026
BOS - PTY
Overall
7.6
Crew
8.1
Boarding
7.8
Comfort
7.4
Entertainment
6.9
Food
6.9
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2026
BOS - PTY
Overall
7.6
Crew
8.1
Boarding
7.8
Comfort
7.4
Entertainment
6.9
Food
6.9
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2026
BOS - PTY
Overall
7.6
Crew
8.1
Boarding
7.8
Comfort
7.4
Entertainment
6.9
Food
6.9
Reviews
1 / 20
2.0
MediocreAnonymous,Jul 2026
BOS - PTY
Related info for your journey
Find useful and relevant information for your journey from Mexico City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Find flights from Mexico City to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Mexico City and Santiago flights
Browse other Mexico City and Santiago flight options. Last updated on September 10, 2026.
Other flights from Mexico City
Browse through other flights departing from Mexico City. Flights are based on user searches made on Cheapflights and were last updated on September 10, 2026.
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Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 10, 2026.
Top 3 airlines flying from Mexico City to Santiago
Discover the top 3 airlines that operate flights from Mexico City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$284 | Average$548 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$423 | Average$642 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$494 | Average$768 | FlexibilityNo cancel fee | On-time81% |