$288+ Cheap flights from O'Hare Intl (ORD) to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/23. Fares are subject to change and may not be available on all flights or dates of travel.
ORD — SCL
Aug 15 — Aug 221
Round-trip
1 adult, Economy
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Cheapest flights from O'Hare Intl to SantiagoExplore the most affordable flight options available from O'Hare Intl to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 16, 2026.
Explore the most affordable flight options available from O'Hare Intl to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 16, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:05 am
ORD
- SCL
2 stops18h 45m
Multiple Airlines
Fri 9/411:22 am
SCL
- ORD
1 stop14h 40m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$593
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/154:49 pm
ORD
- SCL
2 stops31h 57m
Multiple Airlines
Mon 9/285:14 am
SCL
- ORD
1 stop21h 48m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$594
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:59 pm
ORD
- SCL
2 stops34h 15m
Multiple Airlines
Sun 8/304:14 am
SCL
- ORD
1 stop21h 48m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$596
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/109:26 am
ORD
- SCL
2 stops16h 30m
Multiple Airlines
Mon 9/285:14 am
SCL
- ORD
1 stop21h 48m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$599
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:59 pm
ORD
- SCL
2 stops32h 01m
Multiple Airlines
Tue 9/112:06 am
SCL
- ORD
1 stop14h 53m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$602
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:59 pm
ORD
- SCL
2 stops30h 51m
Multiple Airlines
Mon 8/242:56 am
SCL
- ORD
1 stop23h 06m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$604
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:13 pm
ORD
- SCL
2 stops32h 47m
Multiple Airlines
Wed 8/264:14 am
SCL
- ORD
1 stop21h 48m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$613
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/17:44 pm
ORD
- SCL
2 stops22h 48m
Multiple Airlines
Fri 9/411:22 am
SCL
- ORD
1 stop14h 40m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$617
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:59 pm
ORD
- SCL
2 stops32h 01m
Multiple Airlines
Sun 8/304:14 am
SCL
- ORD
1 stop21h 48m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$619
Best flights from O'Hare Intl to SantiagoDiscover carefully curated flight deals from O'Hare Intl to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 16, 2026.
Discover carefully curated flight deals from O'Hare Intl to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 16, 2026.
This Copa Airlines deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/172:13 pm
ORD
- SCL
1 stop31h 06m
Copa Airlines
Mon 12/712:20 pm
SCL
- ORD
1 stop14h 51m
Copa Airlines
Deal found 7/13![Copa Airlines logo]()
$692
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/231:15 pm
ORD
- SCL
1 stop15h 25m
Delta
Mon 11/3011:55 pm
SCL
- ORD
1 stop20h 39m
Delta
Deal found 7/12![Delta logo]()
$704
This FlightHub deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/191:00 pm
ORD
- SCL
1 stop16h 25m
LATAM Airlines
Wed 8/267:50 am
SCL
- ORD
2 stops17h 07m
LATAM Airlines
Deal found 7/11![LATAM Airlines logo]()
$704
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/279:30 am
ORD
- SCL
2 stops17h 30m
Delta
Mon 11/3011:55 pm
SCL
- ORD
1 stop20h 39m
Delta
Deal found 7/13![Delta logo]()
$704
This Delta deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:44 am
ORD
- SCL
2 stops17h 16m
Delta
Sat 9/198:40 pm
SCL
- ORD
1 stop13h 55m
Delta
Deal found 7/12![Delta logo]()
$704
This Delta deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:05 am
ORD
- SCL
1 stop22h 10m
Delta
Mon 8/3111:05 pm
SCL
- ORD
2 stops20h 44m
Delta
Deal found 7/13![Delta logo]()
$704
This Delta deal was found by Cheapflights users on 7/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/51:50 pm
ORD
- SCL
2 stops15h 05m
Delta
Wed 10/147:45 am
SCL
- ORD
2 stops18h 06m
Delta
Deal found 7/11![Delta logo]()
$709
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/228:55 am
ORD
- SCL
2 stops21h 20m
Delta
Sun 10/48:40 pm
SCL
- ORD
2 stops15h 57m
Delta
Deal found 7/14![Delta logo]()
$710
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/72:00 pm
ORD
- SCL
2 stops14h 55m
Delta
Sat 10/108:40 pm
SCL
- ORD
2 stops15h 59m
Delta
Deal found 7/14![Delta logo]()
$710
This Delta deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/183:25 pm
ORD
- SCL
2 stops14h 30m
Delta
Sun 8/308:40 pm
SCL
- ORD
2 stops20h 37m
Delta
Deal found 7/14![Delta logo]()
$710
Last-minute flights from O'Hare Intl to SantiagoDiscover last-minute flight deals from O'Hare Intl to Santiago. Data last updated July 16, 2026 and is based on user searches.
Discover last-minute flight deals from O'Hare Intl to Santiago. Data last updated July 16, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:13 pm
ORD
- SCL
2 stops32h 47m
Multiple Airlines
Wed 8/264:14 am
SCL
- ORD
1 stop21h 48m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$613
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/175:13 pm
ORD
- SCL
2 stops28h 30m
Multiple Airlines
Wed 9/26:40 am
SCL
- ORD
1 stop15h 40m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$621
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:59 pm
ORD
- SCL
2 stops34h 15m
Multiple Airlines
Sun 8/304:14 am
SCL
- ORD
1 stop21h 48m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$596
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:59 pm
ORD
- SCL
2 stops30h 51m
Multiple Airlines
Mon 8/242:56 am
SCL
- ORD
1 stop23h 06m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$604
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:59 pm
ORD
- SCL
2 stops32h 01m
Multiple Airlines
Sun 8/304:14 am
SCL
- ORD
1 stop21h 48m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$619
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:59 pm
ORD
- SCL
2 stops32h 01m
Multiple Airlines
Fri 8/2812:06 am
SCL
- ORD
1 stop25h 56m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$628
This Kiwi.com deal was found by Cheapflights users on 7/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:59 pm
ORD
- SCL
2 stops30h 51m
Multiple Airlines
Wed 9/211:22 am
SCL
- ORD
1 stop14h 40m
Multiple Airlines
Deal found 7/12![Multiple Airlines logo]()
$599
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/316:05 am
ORD
- SCL
2 stops18h 45m
Multiple Airlines
Fri 9/411:22 am
SCL
- ORD
1 stop14h 40m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$593
One-way flights from O'Hare Intl to SantiagoSearch for one-way flight options from O'Hare Intl to Santiago. Find affordable one-way fares based on user searches. Data last updated July 16, 2026.
Search for one-way flight options from O'Hare Intl to Santiago. Find affordable one-way fares based on user searches. Data last updated July 16, 2026.
This Kiwi.com deal was found by Cheapflights users on 7/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/234:49 pm
ORD
- SCL
2 stops49h 43m
Multiple Airlines
Deal found 7/16![Multiple Airlines logo]()
$288
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/207:44 pm
ORD
- SCL
2 stops30h 16m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$291
This Kiwi.com deal was found by Cheapflights users on 7/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/225:59 pm
ORD
- SCL
2 stops48h 37m
Multiple Airlines
Deal found 7/15![Multiple Airlines logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:59 pm
ORD
- SCL
2 stops34h 15m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$293
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/255:59 pm
ORD
- SCL
2 stops34h 15m
Multiple Airlines
Deal found 7/13![Multiple Airlines logo]()
$294
This Kiwi.com deal was found by Cheapflights users on 7/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/256:45 am
ORD
- SCL
1 stop15h 10m
Arajet
Deal found 7/13![Arajet logo]()
$316
This Kiwi.com deal was found by Cheapflights users on 7/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/115:13 pm
ORD
- SCL
2 stops32h 47m
Multiple Airlines
Deal found 7/14![Multiple Airlines logo]()
$322
Find flight deals from O'Hare Intl to Santiago
Discover tips and strategies to find the most affordable flight options for your journey from O'Hare Intl (ORD) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 16, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $573 (Kiwi.com) |
One-way from | $288 (Kiwi.com) |
Popular in | August |
Cheapest in | June |
Average price | $879 |
Cheapflights Fare Finder
Customize your flight search to find flights from O'Hare Intl to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 16, 2026.
Use the filters below to find and compare flights from Chicago O'Hare Intl Airport to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Tue 11/17
2:13 pm-12:19 am
1 stop31h 06m
Santiago Arturo Merino Benitez
Mon 12/7
12:20 pm-12:11 am
1 stop14h 51m
$692
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Mon 11/23
1:15 pm-7:40 am
1 stop15h 25m
Santiago Arturo Merino Benitez
Mon 11/30
11:55 pm-5:34 pm
1 stop20h 39m
$704
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Wed 8/19
1:00 pm-6:25 am
1 stop16h 25m
Santiago Arturo Merino Benitez
Wed 8/26
7:50 am-11:57 pm
2 stops17h 07m
$704
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Fri 11/27
9:30 am-6:00 am
2 stops17h 30m
Santiago Arturo Merino Benitez
Mon 11/30
11:55 pm-5:34 pm
1 stop20h 39m
$704
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Wed 9/16
10:44 am-6:00 am
2 stops17h 16m
Santiago Arturo Merino Benitez
Sat 9/19
8:40 pm-8:35 am
1 stop13h 55m
$704
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Wed 8/19
8:05 am-7:15 am
1 stop22h 10m
Santiago Arturo Merino Benitez
Mon 8/31
11:05 pm-6:49 pm
2 stops20h 44m
$704
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Mon 10/5
1:50 pm-6:55 am
2 stops15h 05m
Santiago Arturo Merino Benitez
Wed 10/14
7:45 am-11:51 pm
2 stops18h 06m
$709
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Tue 9/22
8:55 am-8:15 am
2 stops21h 20m
Santiago Arturo Merino Benitez
Sun 10/4
8:40 pm-10:37 am
2 stops15h 57m
$710
Quickest round-trip
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Wed 10/7
2:00 pm-6:55 am
2 stops14h 55m
Santiago Arturo Merino Benitez
Sat 10/10
8:40 pm-10:39 am
2 stops15h 59m
$710
ChicagoSantiago
ORD - SCL
ORDSCL
Chicago O'Hare Intl
Tue 8/18
3:25 pm-6:55 am
2 stops14h 30m
Santiago Arturo Merino Benitez
Sun 8/30
8:40 pm-4:17 pm
2 stops20h 37m
$710
Showing 1-10 of 19 resultsSorted by cheapest first
Compare providers for flights from O'Hare Intl to Santiago
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from O'Hare Intl to Santiago in July.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Chicago O'Hare Intl Airport-Santiago flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Chicago O'Hare Intl Airport-Santiago flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Chicago O'Hare Intl Airport-Santiago flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Chicago O'Hare Intl Airport-Santiago flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Chicago O'Hare Intl Airport-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from O'Hare Intl to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from O'Hare Intl with our price prediction graph.
ORD-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Chicago O'Hare Intl Airport to Santiago
Prices
Delays
More
How far ahead should I book a flight from Chicago O'Hare Intl Airport to Santiago?
The price you pay for your flight from Chicago O'Hare Intl Airport to Santiago may vary depending on when you book. For the best chance of a lower fare, look to book 37 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Chicago O'Hare Intl Airport to Santiago?
Currently, June is the cheapest month in which you can book a flight from Chicago O'Hare Intl Airport to Santiago (average of $638). Flying from Chicago O'Hare Intl Airport to Santiago in August is currently the most expensive (average of $962). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Chicago O'Hare Intl Airport to Santiago?
How often are flights from Chicago to Santiago delayed?
About 0% of weekly flights between Chicago and Santiago have experienced delays in the past year, with the average delay time being 0 minutes.
What is the most punctual flight time for Chicago to Santiago flights?
Historically, flights departing in the early afternoon are less likely to be delayed, whereas flights leaving in the evening tend to experience delays more often.
What’s the top layover airport for flights from Chicago O'Hare Intl Airport to Santiago?
Share of 1-stop round-trip flights from Chicago O'Hare Intl Airport to Santiago chosen by Cheapflights users in the past 12 months, using the same layover each way.
Panama City (PTY) – chosen by Cheapflights users on 80% of 1-stop itineraries from Chicago O'Hare Intl Airport to Santiago on Cheapflights.
What’s the cheapest layover airport for flights from Chicago O'Hare Intl Airport to Santiago?
Average round-trip fare for 1-stop flights from Chicago O'Hare Intl Airport to Santiago, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Panama City (PTY) is the most affordable 1-stop option, with an average round-trip price of $667.
What’s the fastest layover option from Chicago O'Hare Intl Airport to Santiago?
Shortest average travel time for 1-stop one-way flights from Chicago O'Hare Intl Airport to Santiago, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Panama City (PTY) have the shortest average one-way travel time for 1-stop routes: 12h 58m.
Which airport typically offers the quickest layover for flights from Chicago O'Hare Intl Airport to Santiago?
Average layover duration for 1-stop one-way flights from Chicago O'Hare Intl Airport to Santiago, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Panama City (PTY) offer the fastest connection on this route, with an average layover time of 1h 24m.
Reviews of airlines servicing Santiago
Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated July 16, 2026.
See what other customers who have flown with Delta,Copa Airlines, andLATAM Airlines from Chicago O'Hare Intl Airport to Santiago have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Overall
7.8
Entertainment
7.8
Crew
8.5
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Overall
7.8
Entertainment
7.8
Crew
8.5
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Overall
7.8
Entertainment
7.8
Crew
8.5
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Overall
7.8
Entertainment
7.8
Crew
8.5
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Overall
7.8
Entertainment
7.8
Crew
8.5
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Overall
7.8
Entertainment
7.8
Crew
8.5
Comfort
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from O'Hare Intl to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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O'Hare Intl and Santiago flights
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Top 6 airlines flying from O'Hare Intl to Santiago
Discover the top 6 airlines that operate flights from O'Hare Intl to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 16, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$537 | Average$700 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$540 | Average$744 | FlexibilityNo cancel fee | On-time81% | |
| Cheapest$558 | Average$790 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$597 | Average$881 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$626 | Average$788 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$626 | Average$895 | FlexibilityNo cancel fee | On-timeN/A |