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$531+ Cheap flights from Florence, SC to San Francisco (FLO - SFO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/22. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — SFO
Jun 5 — Jun 121
Fri 6/5
Fri 6/12
1 adult, Economy
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Cheap flight deals from Florence to San Francisco

Cheapest flights from Florence to San Francisco
Explore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 6, 2026.

This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/222:35 pm
FLO
-
SFO
1 stop9h 44m
American Airlines
Sun 5/2412:26 am
SFO
-
FLO
2 stops10h 44m
American Airlines
Deal found 5/1$531
This American Airlines deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/194:02 pm
FLO
-
SFO
1 stop8h 02m
American Airlines
Fri 5/2212:26 am
SFO
-
FLO
2 stops10h 44m
American Airlines
Deal found 5/4$603
This American Airlines deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/134:16 pm
FLO
-
SFO
1 stop9h 59m
American Airlines
Sun 5/179:08 am
SFO
-
FLO
1 stop9h 39m
American Airlines
Deal found 5/5$671
This American Airlines deal was found by Cheapflights users on 5/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/12:35 pm
FLO
-
SFO
2 stops13h 13m
American Airlines
Sun 6/76:00 am
SFO
-
FLO
2 stops13h 00m
American Airlines
Deal found 5/2$733
This American Airlines deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/174:16 pm
FLO
-
SFO
1 stop8h 12m
American Airlines
Thu 5/2111:29 pm
SFO
-
FLO
2 stops11h 41m
American Airlines
Deal found 5/1$1,016

Find flight deals from Florence to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 6, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$531
(American Airlines)
Provider with most accurate pricing for Florence-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Florence-San Francisco flights.
Search Deals
From Florence to San Francisco
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 6, 2026.
Use the filters below to find and compare flights from Florence to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Fri 5/22

2:35 pm-9:19 pm

1 stop9h 44m

San Francisco

Sun 5/24

12:26 am-2:10 pm

2 stops10h 44m

$531
Quickest round-trip

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Tue 5/19

4:02 pm-9:04 pm

1 stop8h 02m

San Francisco

Fri 5/22

12:26 am-2:10 pm

2 stops10h 44m

$603

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Mon 6/1

2:35 pm-12:48 am

2 stops13h 13m

San Francisco

Sun 6/7

6:00 am-10:00 pm

2 stops13h 00m

$733

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sun 5/17

4:16 pm-11:54 pm

2 stops10h 38m

San Francisco

Thu 5/21

11:29 pm-2:10 pm

2 stops11h 41m

$1,204

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/1

Sorted by cheapest first

Compare providers for flights from Florence to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Florence to San Francisco in May.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
ExpediaPrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Florence, South Carolina-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Florence, South Carolina-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Florence, South Carolina-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Florence, South Carolina-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Florence, South Carolina-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Florence to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Florence to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Florence, South Carolina to San Francisco?

    A quick flight from Florence, South Carolina to San Francisco can take about 9h 44m. American Airlines provides one of the quickest options available for as low as $531. Florence, South Carolina and San Francisco are separated by a distance of 2377 mi.

  • Can I find deals for flights from Florence to San Francisco that include hotel bookings?

    Yes. In addition to deals on Florence to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to San Francisco.

  • Can I find deals for business class flights from Florence to San Francisco?

    Yes. Cheapflights offers flight deals from Florence to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Cruz
Santa Clara
Fairfield
Rancho Cordova
San Bruno
Watsonville
San Ramon
Emeryville
Vacaville
Roseville
San Carlos
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Davis
Manteca
Union City
Elk Grove

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