$234+ Cheap flights from Florence, SC to San Francisco (FLO - SFO)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — SFO
Oct 24 — Oct 311
Round-trip
1 adult, Economy
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Find cheap flights from Florence to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Florence to San Francisco
Cheapest
Best
Last-minute
One-way
Cheapest flights from Florence to San FranciscoExplore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2026.
Explore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 24, 2026.
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:30 am -
1 stop7h 46m
Sat 10/101:27 pm -
1 stop7h 30m
Deal found 9/21![American Airlines logo]()
$607
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/291:43 pm -
1 stop9h 25m
Mon 10/51:27 pm -
1 stop7h 30m
Deal found 9/19![American Airlines logo]()
$628
Best flights from Florence to San FranciscoDiscover carefully curated flight deals from Florence to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 24, 2026.
Discover carefully curated flight deals from Florence to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 24, 2026.
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:30 am -
1 stop7h 46m
Sat 10/101:27 pm -
1 stop7h 30m
Deal found 9/21![American Airlines logo]()
$607
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:09 am -
2 stops11h 52m
Sun 10/1110:51 am -
1 stop10h 06m
Deal found 9/22![American Airlines logo]()
$719
Last-minute flights from Florence to San FranciscoDiscover last-minute flight deals from Florence to San Francisco. Data last updated September 24, 2026 and is based on user searches.
Discover last-minute flight deals from Florence to San Francisco. Data last updated September 24, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/291:43 pm -
1 stop9h 25m
Mon 10/51:27 pm -
1 stop7h 30m
Deal found 9/19![American Airlines logo]()
$628
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:30 am -
1 stop7h 46m
Sat 10/101:27 pm -
1 stop7h 30m
Deal found 9/21![American Airlines logo]()
$607
One-way flights from Florence to San FranciscoSearch for one-way flight options from Florence to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 24, 2026.
Search for one-way flight options from Florence to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 24, 2026.
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/262:34 pm -
1 stop8h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/19![American Airlines logo]()
$234
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/312:35 pm -
1 stop10h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![American Airlines logo]()
$304
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/295:09 am -
1 stop10h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![American Airlines logo]()
$450
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/42:35 pm -
1 stop10h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![American Airlines logo]()
$469
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/32:35 pm -
1 stop10h 12m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![American Airlines logo]()
$490
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/31:43 pm -
1 stop7h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![American Airlines logo]()
$509
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/104:03 pm -
2 stops10h 07m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![American Airlines logo]()
$535
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/15:09 am -
2 stops16h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![American Airlines logo]()
$580
Find flight deals from Florence to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 24, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $607 (American Airlines) |
One-way from | $234 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Florence to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 24, 2026.
Use the filters below to find and compare flights from Florence to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
FlorenceSan Francisco
FLO Florence - SFO San Francisco
FLOSFO
Florence
Mon 10/26
2:34 pm-8:24 pm
1 stop8h 50m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$234
FlorenceSan Francisco
FLO Florence - SFO San Francisco
FLOSFO
Florence
Thu 12/31
5:09 am-12:29 pm
1 stop10h 20m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$304
FlorenceSan Francisco
FLO Florence - SFO San Francisco
FLOSFO
Florence
Wed 12/30
2:35 pm-9:47 pm
1 stop10h 12m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$450
FlorenceSan Francisco
FLO Florence - SFO San Francisco
FLOSFO
Florence
Mon 1/4
2:35 pm-9:47 pm
1 stop10h 12m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$469
FlorenceSan Francisco
FLO Florence - SFO San Francisco
FLOSFO
Florence
Sun 1/3
2:35 pm-9:47 pm
1 stop10h 12m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$490
Quickest round-trip
FlorenceSan Francisco
FLO Florence - SFO San Francisco
FLOSFO
Florence
Sat 10/3
1:43 pm-6:08 pm
1 stop7h 25m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$509
FlorenceSan Francisco
FLO Florence - SFO San Francisco
FLOSFO
Florence
Sun 1/10
4:03 pm-10:43 pm
1 stop9h 40m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$573
FlorenceSan Francisco
FLO Florence - SFO San Francisco
FLOSFO
Florence
Tue 10/6
6:30 am-11:16 am
1 stop7h 46m
San Francisco
Sat 10/10
1:27 pm-11:57 pm
1 stop7h 30m
$607
FlorenceSan Francisco
FLO Florence - SFO San Francisco
FLOSFO
Florence
Sat 1/2
5:09 am-9:49 am
2 stops31h 40m
San Francisco
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$636
FlorenceSan Francisco
FLO Florence - SFO San Francisco
FLOSFO
Florence
Wed 10/7
5:09 am-2:01 pm
2 stops11h 52m
San Francisco
Sun 10/11
10:51 am-11:57 pm
1 stop10h 06m
$719
Sorted by cheapest first
Compare providers for flights from Florence to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Florence to San Francisco in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Florence, South Carolina-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Florence, South Carolina-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Florence, South Carolina-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Florence, South Carolina-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Florence, South Carolina-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Florence to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Florence with our price prediction graph.
FLO-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Florence to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Clara
Santa Cruz
Walnut Creek
Emeryville
Burlingame
Rancho Cordova
San Bruno
Roseville
Hayward
Cupertino
Newark
Fairfield
San Ramon
Redwood City
Manteca
Vallejo
San Carlos
Turlock
Davis
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