$199+ Cheap flights from Florence, SC to San Francisco (FLO - SFO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/19. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — SFO
Apr 2 — Apr 91
1 adult, Economy
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Find cheap flights from Florence to San Francisco with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Florence to San Francisco
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Best
Last-minute
One-way
Cheapest flights from Florence to San FranciscoExplore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 3, 2026.
Explore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 3, 2026.
This American Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/135:16 am
FLO
- SFO
1 stop10h 01m
American Airlines
Tue 3/1712:31 pm
SFO
- FLO
1 stop7h 37m
American Airlines
Deal found 2/26![American Airlines logo]()
$557
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:16 am
FLO
- SFO
1 stop10h 01m
American Airlines
Wed 3/251:18 pm
SFO
- FLO
1 stop7h 39m
American Airlines
Deal found 2/28![American Airlines logo]()
$579
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/176:15 am
FLO
- SFO
1 stop10h 45m
American Airlines
Sat 3/217:00 am
SFO
- FLO
1 stop7h 50m
American Airlines
Deal found 3/2![American Airlines logo]()
$665
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/155:16 am
FLO
- SFO
1 stop10h 01m
American Airlines
Thu 3/191:18 pm
SFO
- FLO
1 stop7h 39m
American Airlines
Deal found 2/28![American Airlines logo]()
$697
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/146:25 pm
FLO
- SFO
1 stop7h 45m
American Airlines
Wed 3/251:18 pm
SFO
- FLO
1 stop7h 39m
American Airlines
Deal found 2/28![American Airlines logo]()
$699
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/165:16 am
FLO
- SFO
2 stops12h 49m
American Airlines
Fri 3/201:18 pm
SFO
- FLO
1 stop7h 39m
American Airlines
Deal found 3/1![American Airlines logo]()
$702
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:15 am
FLO
- SFO
2 stops11h 19m
American Airlines
Sat 3/287:00 am
SFO
- FLO
1 stop7h 50m
American Airlines
Deal found 2/28![American Airlines logo]()
$704
Best flights from Florence to San FranciscoDiscover carefully curated flight deals from Florence to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 3, 2026.
Discover carefully curated flight deals from Florence to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 3, 2026.
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/155:16 am
FLO
- SFO
1 stop10h 01m
American Airlines
Thu 3/191:18 pm
SFO
- FLO
1 stop7h 39m
American Airlines
Deal found 2/28![American Airlines logo]()
$697
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/165:16 am
FLO
- SFO
2 stops12h 49m
American Airlines
Fri 3/201:18 pm
SFO
- FLO
1 stop7h 39m
American Airlines
Deal found 3/1![American Airlines logo]()
$702
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/185:16 am
FLO
- SFO
1 stop10h 01m
American Airlines
Sun 3/227:00 am
SFO
- FLO
1 stop7h 50m
American Airlines
Deal found 3/3![American Airlines logo]()
$729
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/176:15 am
FLO
- SFO
2 stops11h 19m
American Airlines
Sat 3/216:00 am
SFO
- FLO
2 stops14h 57m
American Airlines
Deal found 3/2![American Airlines logo]()
$751
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/135:16 am
FLO
- SFO
1 stop10h 01m
American Airlines
Tue 3/246:45 am
SFO
- FLO
2 stops13h 23m
American Airlines
Deal found 2/28![American Airlines logo]()
$775
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/72:35 pm
FLO
- SFO
1 stop9h 44m
American Airlines
Fri 6/126:00 am
SFO
- FLO
2 stops13h 00m
American Airlines
Deal found 3/2![American Airlines logo]()
$920
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:20 pm
FLO
- SFO
1 stop7h 50m
American Airlines
Sun 3/226:00 am
SFO
- FLO
2 stops8h 50m
American Airlines
Deal found 2/28![American Airlines logo]()
$928
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/146:25 pm
FLO
- SFO
1 stop7h 45m
American Airlines
Sun 3/227:00 am
SFO
- FLO
1 stop7h 50m
American Airlines
Deal found 2/28![American Airlines logo]()
$1,201
Last-minute flights from Florence to San FranciscoDiscover last-minute flight deals from Florence to San Francisco. Data last updated March 3, 2026 and is based on user searches.
Discover last-minute flight deals from Florence to San Francisco. Data last updated March 3, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:15 am
FLO
- SFO
2 stops11h 19m
American Airlines
Sat 3/287:00 am
SFO
- FLO
1 stop7h 50m
American Airlines
Deal found 2/28![American Airlines logo]()
$704
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/115:16 am
FLO
- SFO
1 stop10h 01m
American Airlines
Wed 3/251:18 pm
SFO
- FLO
1 stop7h 39m
American Airlines
Deal found 2/28![American Airlines logo]()
$579
This American Airlines deal was found by Cheapflights users on 2/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/135:16 am
FLO
- SFO
1 stop10h 01m
American Airlines
Tue 3/1712:31 pm
SFO
- FLO
1 stop7h 37m
American Airlines
Deal found 2/26![American Airlines logo]()
$557
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/146:25 pm
FLO
- SFO
1 stop7h 45m
American Airlines
Sat 3/287:00 am
SFO
- FLO
1 stop7h 50m
American Airlines
Deal found 2/28![American Airlines logo]()
$699
This American Airlines deal was found by Cheapflights users on 2/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/155:16 am
FLO
- SFO
1 stop10h 01m
American Airlines
Thu 3/191:18 pm
SFO
- FLO
1 stop7h 39m
American Airlines
Deal found 2/28![American Airlines logo]()
$697
This American Airlines deal was found by Cheapflights users on 3/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/165:16 am
FLO
- SFO
2 stops12h 49m
American Airlines
Fri 3/201:18 pm
SFO
- FLO
1 stop7h 39m
American Airlines
Deal found 3/1![American Airlines logo]()
$702
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/176:15 am
FLO
- SFO
1 stop10h 45m
American Airlines
Sat 3/217:00 am
SFO
- FLO
1 stop7h 50m
American Airlines
Deal found 3/2![American Airlines logo]()
$665
One-way flights from Florence to San FranciscoSearch for one-way flight options from Florence to San Francisco. Find affordable one-way fares based on user searches. Data last updated March 3, 2026.
Search for one-way flight options from Florence to San Francisco. Find affordable one-way fares based on user searches. Data last updated March 3, 2026.
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/194:02 pm
FLO
- SFO
1 stop8h 02m
American Airlines
Deal found 3/2![American Airlines logo]()
$199
This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/165:16 am
FLO
- SFO
1 stop10h 01m
American Airlines
Deal found 3/2![American Airlines logo]()
$359
Find flight deals from Florence to San Francisco
Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 3, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $665 (American Airlines) |
One-way from | $199 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Florence to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 3, 2026.
Use the filters below to find and compare flights from Florence to San Francisco that are best for you.
Fly from
Fly to
Route
Depart
Return
FlorenceSan Francisco
FLO - SFO
FLOSFO
Florence
Sun 3/15
5:16 am-12:17 pm
1 stop10h 01m
San Francisco
Thu 3/19
1:18 pm-11:57 pm
1 stop7h 39m
$697
FlorenceSan Francisco
FLO - SFO
FLOSFO
Florence
Mon 3/16
5:16 am-3:05 pm
2 stops12h 49m
San Francisco
Fri 3/20
1:18 pm-11:57 pm
1 stop7h 39m
$702
FlorenceSan Francisco
FLO - SFO
FLOSFO
Florence
Wed 3/18
5:16 am-12:17 pm
1 stop10h 01m
San Francisco
Sun 3/22
7:00 am-5:50 pm
1 stop7h 50m
$729
FlorenceSan Francisco
FLO - SFO
FLOSFO
Florence
Tue 3/17
6:15 am-2:34 pm
2 stops11h 19m
San Francisco
Sat 3/21
6:00 am-11:57 pm
2 stops14h 57m
$751
FlorenceSan Francisco
FLO - SFO
FLOSFO
Florence
Fri 3/13
5:16 am-12:17 pm
1 stop10h 01m
San Francisco
Tue 3/24
6:45 am-11:08 pm
2 stops13h 23m
$775
FlorenceSan Francisco
FLO - SFO
FLOSFO
Florence
Sun 6/7
2:35 pm-9:19 pm
1 stop9h 44m
San Francisco
Fri 6/12
6:00 am-10:00 pm
2 stops13h 00m
$920
FlorenceSan Francisco
FLO - SFO
FLOSFO
Florence
Fri 3/13
6:20 pm-11:10 pm
1 stop7h 50m
San Francisco
Sun 3/22
6:00 am-5:50 pm
2 stops8h 50m
$928
FlorenceSan Francisco
FLO - SFO
FLOSFO
Florence
Sat 3/14
6:25 pm-11:10 pm
1 stop7h 45m
San Francisco
Sun 3/22
7:00 am-5:50 pm
1 stop7h 50m
$1,201
FlorenceSan Francisco
FLO - SFO
FLOSFO
Florence
Tue 5/19
4:02 pm-9:04 pm
1 stop8h 02m
$199
FlorenceSan Francisco
FLO - SFO
FLOSFO
Florence
Mon 3/16
5:16 am-2:34 pm
2 stops12h 18m
$364
Sorted by cheapest first
Compare providers for flights from Florence to San Francisco
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Florence to San Francisco in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Florence, South Carolina-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Florence, South Carolina-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Florence, South Carolina-San Francisco flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Florence, South Carolina-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Florence, South Carolina-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Florence to San Francisco
Have a flexible travel schedule? Discover the best time to fly to San Francisco from Florence with our price prediction graph.
FLO-SFO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Florence to San Francisco
Reviews of airlines servicing San Francisco
Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated March 3, 2026.
Peruse reviews from past customers who have flown with American Airlines from Florence to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.0
Food
6.4
Comfort
7.2
Overall
7.1
Entertainment
6.9
Boarding
7.5
Reviews
1 / 20
10.0
ExcellentAnonymous,Apr 2025
MYR - CLT
Crew
8.0
Food
6.4
Comfort
7.2
Overall
7.1
Entertainment
6.9
Boarding
7.5
Reviews
1 / 20
10.0
ExcellentAnonymous,Apr 2025
MYR - CLT
Related info for your journey
Find useful and relevant information for your journey from Florence to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Francisco?
Book flights to San Francisco if you plan to visit one of these locationsSouth San Francisco
Santa Cruz
Santa Clara
Livermore
Roseville
Watsonville
San Bruno
Daly City
Sunnyvale
Vacaville
Turlock
San Carlos
San Ramon
Redwood City
Rancho Cordova
San Lorenzo
Davis
Hollister
Manteca
Union City
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Florence and San Francisco flights
Browse other Florence and San Francisco flight options. Last updated on March 3, 2026.
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Top airline flying from Florence to San Francisco
Discover the top airline that operate flights from Florence to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 3, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$326 | Average$462 | FlexibilityNo cancel fee | On-time71% |