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San Diego

$105+ Cheap flights from South Carolina to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/23. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SAN
May 23 — May 301
Sat 5/23
Sat 5/30
1 adult, Economy
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Cheap flight deals from South Carolina to San Diego

Cheapest flights from South Carolina to San Diego
Explore the most affordable flight options available from South Carolina to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 23, 2026.

This United Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/1210:15 am
CHS
-
SAN
1 stop8h 05m
United Airlines
Tue 5/198:54 am
SAN
-
CHS
1 stop7h 38m
United Airlines
Deal found 4/21$250
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/124:20 pm
CHS
-
SAN
1 stop8h 40m
American Airlines
Tue 5/1911:58 am
SAN
-
CHS
1 stop6h 48m
American Airlines
Deal found 4/21$255
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/144:46 pm
CHS
-
SAN
1 stop7h 04m
American Airlines
Tue 5/196:40 am
SAN
-
CHS
1 stop9h 09m
American Airlines
Deal found 4/20$280
This United Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:07 pm
CHS
-
SAN
1 stop7h 18m
United Airlines
Sat 5/238:32 pm
SAN
-
CHS
2 stops10h 51m
United Airlines
Deal found 4/22$285
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/307:11 pm
CHS
-
SAN
1 stop7h 48m
American Airlines
Wed 6/310:57 am
SAN
-
CHS
1 stop9h 01m
American Airlines
Deal found 4/22$289
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/136:15 am
CHS
-
SAN
1 stop8h 01m
Delta
Tue 5/1910:49 am
SAN
-
CHS
1 stop8h 03m
Delta
Deal found 4/21$297
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:00 am
MYR
-
SAN
1 stop6h 39m
Delta
Wed 6/31:50 pm
SAN
-
MYR
1 stop7h 08m
Delta
Deal found 4/20$299
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/311:28 am
GSP
-
SAN
1 stop8h 02m
Delta
Wed 6/106:15 am
SAN
-
GSP
1 stop6h 55m
Delta
Deal found 4/21$299
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/145:15 am
CHS
-
SAN
1 stop7h 24m
Delta
Tue 5/1912:41 pm
SAN
-
CHS
1 stop7h 15m
Delta
Deal found 4/21$301
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/142:55 pm
CHS
-
SAN
1 stop8h 55m
American Airlines
Mon 5/189:45 pm
SAN
-
CHS
1 stop9h 07m
American Airlines
Deal found 4/20$305
This American Airlines deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/293:43 pm
CHS
-
SAN
1 stop7h 24m
American Airlines
Tue 6/29:25 pm
SAN
-
CHS
1 stop9h 42m
American Airlines
Deal found 4/21$306
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/128:20 am
CHS
-
SAN
1 stop7h 18m
Delta
Mon 5/181:50 pm
SAN
-
CHS
1 stop7h 09m
Delta
Deal found 4/21$309

Find flight deals from South Carolina to San Diego

Keep the following information in mind while searching for South Carolina to San Diego flight deals. Data was last updated April 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$250
(United Airlines)

One-way from

$105
(Frontier)

Popular in

December

Cheapest in

September

Average price

$519
Provider with most accurate pricing for Myrtle Beach Intl-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-San Diego flights.
Search Deals
From South Carolina to San Diego
Search Deals
One-way flight from South Carolina to San Diego
Search Deals
Highest demand for flights based on searches. 15% potential increase in price ($87 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
Use the filters below to find and compare flights from South Carolina to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonSan Diego

CHS - SAN

CHSSAN

Charleston

Fri 9/4

4:26 pm-10:27 pm

1 stop9h 01m

San Diego

Tue 9/8

9:05 pm-8:52 am

1 stop8h 47m

$306

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Thu 5/28

5:40 am-9:39 am

1 stop6h 59m

San Diego

Wed 6/10

6:15 am-4:10 pm

1 stop6h 55m

$331

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Tue 5/12

6:00 am-9:39 am

1 stop6h 39m

San Diego

Tue 5/19

12:41 pm-11:58 pm

1 stop8h 17m

$343

AugustaSan Diego

AGS - SAN

AGSSAN

Augusta Bush Field

Fri 5/29

7:50 pm-11:27 pm

1 stop6h 37m

San Diego

Wed 6/3

10:25 pm-9:18 am

1 stop7h 53m

$349

AugustaSan Diego

AGS - SAN

AGSSAN

Augusta Bush Field

Sat 7/18

5:00 am-9:00 am

1 stop7h 00m

San Diego

Mon 7/27

9:25 pm-8:29 am

1 stop8h 04m

$370

CharlestonSan Diego

CHS - SAN

CHSSAN

Charleston

Tue 8/25

4:26 pm-10:27 pm

1 stop9h 01m

San Diego

Wed 8/26

6:55 pm-10:02 am

2 stops12h 07m

$370

AugustaSan Diego

AGS - SAN

AGSSAN

Augusta Bush Field

Sat 5/16

12:54 pm-7:00 pm

1 stop9h 06m

San Diego

Sat 6/13

9:25 pm-8:29 am

1 stop8h 04m

$370

CharlestonSan Diego

CHS - SAN

CHSSAN

Charleston

Fri 9/4

8:40 am-6:10 pm

2 stops12h 30m

San Diego

Tue 9/8

6:20 am-6:20 pm

1 stop9h 00m

$371

CharlestonSan Diego

CHS - SAN

CHSSAN

Charleston

Wed 6/3

2:25 pm-10:25 pm

1 stop11h 00m

San Diego

Mon 6/8

8:00 am-8:40 pm

2 stops9h 40m

$371

ColumbiaSan Diego

CAE - SAN

CAESAN

Columbia Metropolitan

Wed 7/8

2:51 pm-8:23 pm

1 stop8h 32m

San Diego

Sat 7/11

9:45 pm-9:54 am

1 stop9h 09m

$373

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/22

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from South Carolina to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to San Diego

What is the cheapest month to book a flight from South Carolina to San Diego?

Currently, July is the cheapest month in which you can book a flight from South Carolina to San Diego (average of $111). Flying from South Carolina to San Diego in March is currently the most expensive (average of $304). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from South Carolina to San Diego?

Related info for your journey

Find useful and relevant information for your journey from South Carolina to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from South Carolina?

    San Diego (SAN) is the airport you will fly into if you book a flight from South Carolina to San Diego. It is only a 2.6 mi journey from San Diego (SAN) to San Diego’s city center.

  • How long is the flight from South Carolina to San Diego?

    A quick flight from South Carolina to San Diego can take about 6h 59m. United Airlines provides one of the quickest options available for as low as $331. South Carolina and San Diego are separated by a distance of 2002 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from South Carolina to San Diego one-way?

    To fly one-way, consider booking your trip with United Airlines, which is currently one of the cheapest options available, starting at $153. Alaska Airlines flights start at $160 while deals on Delta start at $169 one-way.

  • What are the most popular routes from South Carolina to San Diego?

    The most popular flight routes from South Carolina to San Diego are Charlotte Douglas - San Diego, Charleston - San Diego and Savannah/Hilton Head - San Diego.

  • Can I find deals for flights from South Carolina to San Diego that include hotel bookings?

    Yes. In addition to deals on South Carolina to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to San Diego.

  • Can I find deals for business class flights from South Carolina to San Diego?

    Yes. Cheapflights offers flight deals from South Carolina to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to San Diego?

    Currently, July is the cheapest month in which you can book a flight from South Carolina to San Diego (average of $111). Flying from South Carolina to San Diego in March is currently the most expensive (average of $304). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
National City
Coronado
La Mesa
Poway
Julian
Lemon Grove

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Alternative routes for South Carolina to San Diego

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Top 5 airlines flying from South Carolina to San Diego

Discover the top 5 airlines that operate flights from South Carolina to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 23, 2026.
AirlineCheapestAverageFlexibilityOn-time
JetBlueCheapest$137Average$268FlexibilityNo cancel feeOn-time62%
DeltaCheapest$148Average$467FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$228Average$470FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$270Average$454FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$305Average$499FlexibilityNo cancel feeOn-time63%

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