$192+ Cheap flights from Greenville to San Diego (GSP - SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/26. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — SAN
Jun 28 — Jul 51
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Greenville to San Diego
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Best
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Cheapest flights from Greenville to San DiegoExplore the most affordable flight options available from Greenville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 29, 2026.
Explore the most affordable flight options available from Greenville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 29, 2026.
This Southwest deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:00 am
GSP
- SAN
1 stop6h 10m
Southwest
Wed 8/197:20 am
SAN
- GSP
1 stop6h 25m
Southwest
Deal found 5/28![Southwest logo]()
$300
This Southwest deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:45 am
GSP
- SAN
1 stop6h 05m
Southwest
Sat 8/2910:40 pm
SAN
- GSP
1 stop8h 30m
Southwest
Deal found 5/28![Southwest logo]()
$363
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/85:45 am
GSP
- SAN
1 stop6h 58m
Delta
Tue 9/1511:30 am
SAN
- GSP
1 stop6h 56m
Delta
Deal found 5/28![Delta logo]()
$383
This Southwest deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/127:00 am
GSP
- SAN
1 stop6h 10m
Southwest
Tue 8/188:05 am
SAN
- GSP
2 stops9h 50m
Southwest
Deal found 5/28![Southwest logo]()
$388
This Southwest deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/151:50 pm
GSP
- SAN
1 stop12h 40m
Southwest
Wed 7/229:40 pm
SAN
- GSP
1 stop12h 35m
Southwest
Deal found 5/28![Southwest logo]()
$394
This Southwest deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:55 pm
GSP
- SAN
1 stop7h 30m
Southwest
Tue 8/188:05 am
SAN
- GSP
2 stops9h 50m
Southwest
Deal found 5/26![Southwest logo]()
$398
Best flights from Greenville to San DiegoDiscover carefully curated flight deals from Greenville to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 29, 2026.
Discover carefully curated flight deals from Greenville to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 29, 2026.
This Southwest deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:00 am
GSP
- SAN
1 stop6h 10m
Southwest
Wed 8/1910:40 pm
SAN
- GSP
2 stops10h 50m
Southwest
Deal found 5/28![Southwest logo]()
$306
This Delta deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/92:51 pm
GSP
- SAN
1 stop7h 44m
Delta
Wed 8/126:15 am
SAN
- GSP
1 stop7h 00m
Delta
Deal found 5/27![Delta logo]()
$425
This United Airlines deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/253:01 pm
GSP
- SAN
1 stop8h 28m
United Airlines
Wed 8/2610:40 pm
SAN
- GSP
1 stop7h 55m
United Airlines
Deal found 5/26![United Airlines logo]()
$493
This Southwest deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/223:30 pm
GSP
- SAN
2 stops8h 35m
Southwest
Sat 8/2910:40 pm
SAN
- GSP
2 stops11h 00m
Southwest
Deal found 5/28![Southwest logo]()
$373
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/87:10 am
GSP
- SAN
1 stop9h 59m
Delta
Mon 7/132:18 pm
SAN
- GSP
1 stop6h 36m
Delta
Deal found 5/25![Delta logo]()
$431
This Southwest deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/137:00 am
GSP
- SAN
2 stops8h 35m
Southwest
Tue 8/188:35 am
SAN
- GSP
2 stops9h 20m
Southwest
Deal found 5/26![Southwest logo]()
$403
This Delta deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/72:51 pm
GSP
- SAN
1 stop9h 12m
Delta
Mon 8/1010:30 pm
SAN
- GSP
1 stop7h 48m
Delta
Deal found 5/24![Delta logo]()
$467
This Southwest deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/168:25 am
GSP
- SAN
2 stops8h 50m
Southwest
Tue 6/1610:40 pm
SAN
- GSP
1 stop10h 35m
Southwest
Deal found 5/25![Southwest logo]()
$448
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/243:42 pm
GSP
- SAN
1 stop7h 36m
Delta
Mon 11/3010:30 pm
SAN
- GSP
1 stop9h 03m
Delta
Deal found 5/28![Delta logo]()
$467
This Southwest deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/27:05 am
GSP
- SAN
2 stops9h 10m
Southwest
Sun 7/56:30 am
SAN
- GSP
2 stops9h 20m
Southwest
Deal found 5/28![Southwest logo]()
$477
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1111:10 am
GSP
- SAN
1 stop10h 17m
Delta
Sun 10/1810:40 pm
SAN
- GSP
1 stop7h 45m
Delta
Deal found 5/25![Delta logo]()
$493
This Southwest deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/66:50 pm
GSP
- SAN
1 stop6h 40m
Southwest
Thu 7/96:20 am
SAN
- GSP
2 stops8h 55m
Southwest
Deal found 5/25![Southwest logo]()
$494
Last-minute flights from Greenville to San DiegoDiscover last-minute flight deals from Greenville to San Diego. Data last updated May 29, 2026 and is based on user searches.
Discover last-minute flight deals from Greenville to San Diego. Data last updated May 29, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/165:44 am
GSP
- SAN
1 stop6h 49m
Delta
Tue 6/162:31 pm
SAN
- GSP
1 stop6h 28m
Delta
Deal found 5/25![Delta logo]()
$395
This Southwest deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/168:25 am
GSP
- SAN
2 stops8h 50m
Southwest
Tue 6/1610:40 pm
SAN
- GSP
1 stop10h 35m
Southwest
Deal found 5/25![Southwest logo]()
$448
This United Airlines deal was found by Cheapflights users on 5/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/224:15 pm
GSP
- SAN
1 stop9h 10m
United Airlines
Mon 6/2910:25 pm
SAN
- GSP
1 stop8h 30m
United Airlines
Deal found 5/25![United Airlines logo]()
$503
This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/245:25 pm
GSP
- SAN
1 stop8h 14m
American Airlines
Tue 6/306:15 am
SAN
- GSP
1 stop7h 17m
American Airlines
Deal found 5/27![American Airlines logo]()
$410
This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/277:55 pm
GSP
- SAN
1 stop7h 04m
American Airlines
Fri 7/1011:07 am
SAN
- GSP
1 stop9h 09m
American Airlines
Deal found 5/27![American Airlines logo]()
$467
This Southwest deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/271:55 pm
GSP
- SAN
1 stop8h 00m
Southwest
Fri 7/1010:40 am
SAN
- GSP
2 stops9h 15m
Southwest
Deal found 5/27![Southwest logo]()
$482
This Southwest deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/296:50 pm
GSP
- SAN
1 stop6h 35m
Southwest
Fri 7/39:20 am
SAN
- GSP
2 stops10h 30m
Southwest
Deal found 5/26![Southwest logo]()
$472
One-way flights from Greenville to San DiegoSearch for one-way flight options from Greenville to San Diego. Find affordable one-way fares based on user searches. Data last updated May 29, 2026.
Search for one-way flight options from Greenville to San Diego. Find affordable one-way fares based on user searches. Data last updated May 29, 2026.
This American Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/267:00 am
GSP
- SAN
1 stop9h 07m
American Airlines
Deal found 5/27![American Airlines logo]()
$192
This United Airlines deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/2610:33 am
GSP
- SAN
2 stops9h 53m
United Airlines
Deal found 5/27![United Airlines logo]()
$197
This American Airlines deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:28 pm
GSP
- SAN
1 stop9h 31m
American Airlines
Deal found 5/24![American Airlines logo]()
$211
This Southwest deal was found by Cheapflights users on 5/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/138:40 am
GSP
- SAN
2 stops12h 30m
Southwest
Deal found 5/24![Southwest logo]()
$216
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/263:35 pm
GSP
- SAN
3 stops49h 33m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$230
This Delta deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/233:06 pm
GSP
- SAN
1 stop9h 10m
Delta
Deal found 5/28![Delta logo]()
$234
This Southwest deal was found by Cheapflights users on 5/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/237:05 am
GSP
- SAN
2 stops8h 45m
Southwest
Deal found 5/28![Southwest logo]()
$239
This Kiwi.com deal was found by Cheapflights users on 5/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/238:46 pm
GSP
- SAN
3 stops30h 05m
Multiple Airlines
Deal found 5/27![Multiple Airlines logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 5/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/410:35 am
GSP
- SAN
1 stop28h 13m
Breeze Airways
Deal found 5/26![Breeze Airways logo]()
$278
Find flight deals from Greenville to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 29, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $300 (Southwest) |
One-way from | $192 (American Airlines) |
Popular in | June |
Cheapest in | January |
Average price | $492 |
Cheapflights Fare Finder
Customize your flight search to find flights from Greenville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 29, 2026.
Use the filters below to find and compare flights from Greenville to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvilleSan Diego
GSP - SAN
GSPSAN
Greenville
Tue 8/11
7:00 am-10:10 am
1 stop6h 10m
San Diego
Wed 8/19
10:40 pm-12:30 pm
2 stops10h 50m
$306
GreenvilleSan Diego
GSP - SAN
GSPSAN
Greenville
Sat 8/22
3:30 pm-9:05 pm
2 stops8h 35m
San Diego
Sat 8/29
10:40 pm-12:40 pm
2 stops11h 00m
$373
GreenvilleSan Diego
GSP - SAN
GSPSAN
Greenville
Thu 8/13
7:00 am-12:35 pm
2 stops8h 35m
San Diego
Tue 8/18
8:35 am-8:55 pm
2 stops9h 20m
$403
Quickest round-trip
GreenvilleSan Diego
GSP - SAN
GSPSAN
Greenville
Sun 8/9
2:51 pm-7:35 pm
1 stop7h 44m
San Diego
Wed 8/12
6:15 am-4:15 pm
1 stop7h 00m
$425
GreenvilleSan Diego
GSP - SAN
GSPSAN
Greenville
Wed 7/8
7:10 am-2:09 pm
1 stop9h 59m
San Diego
Mon 7/13
2:18 pm-11:54 pm
1 stop6h 36m
$431
GreenvilleSan Diego
GSP - SAN
GSPSAN
Greenville
Tue 6/16
8:25 am-2:15 pm
2 stops8h 50m
San Diego
Tue 6/16
10:40 pm-12:15 pm
1 stop10h 35m
$448
GreenvilleSan Diego
GSP - SAN
GSPSAN
Greenville
Fri 8/7
2:51 pm-9:03 pm
1 stop9h 12m
San Diego
Mon 8/10
10:30 pm-9:18 am
1 stop7h 48m
$467
GreenvilleSan Diego
GSP - SAN
GSPSAN
Greenville
Tue 11/24
3:42 pm-8:18 pm
1 stop7h 36m
San Diego
Mon 11/30
10:30 pm-10:33 am
1 stop9h 03m
$467
GreenvilleSan Diego
GSP - SAN
GSPSAN
Greenville
Thu 7/2
7:05 am-1:15 pm
2 stops9h 10m
San Diego
Sun 7/5
6:30 am-6:50 pm
2 stops9h 20m
$477
GreenvilleSan Diego
GSP - SAN
GSPSAN
Greenville
Tue 8/25
3:01 pm-8:29 pm
1 stop8h 28m
San Diego
Wed 8/26
10:40 pm-9:35 am
1 stop7h 55m
$493
Showing 1-10 of 22 resultsSorted by cheapest first
Compare providers for flights from Greenville to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to San Diego in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Greenville-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Greenville-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Greenville to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Greenville with our price prediction graph.
GSP-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Greenville to San Diego
How far ahead should I book a flight from Greenville to San Diego?
The price you pay for your flight from Greenville to San Diego may vary depending on when you book. For the best chance of a lower fare, look to book 56 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Greenville to San Diego?
Currently, January is the cheapest month in which you can book a flight from Greenville to San Diego (average of $367). Flying from Greenville to San Diego in June is currently the most expensive (average of $586). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Greenville to San Diego?
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated May 29, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Greenville to San Diego to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Entertainment
7.5
Comfort
8.0
Overall
8.0
Food
7.0
Boarding
8.1
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Greenville to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
Chula Vista
National City
Coronado
Poway
La Mesa
Julian
Santee
Lemon Grove
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Find flights from Greenville to San Diego, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Greenville and San Diego flights
Browse other Greenville and San Diego flight options. Last updated on May 29, 2026.
Other flights from Greenville
Browse through other flights departing from Greenville. Flights are based on user searches made on Cheapflights and were last updated on May 29, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on May 29, 2026.
Top 4 airlines flying from Greenville to San Diego
Discover the top 4 airlines that operate flights from Greenville to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 29, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$304 | Average$478 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$305 | Average$516 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$312 | Average$466 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$312 | Average$471 | FlexibilityNo cancel fee | On-time71% |