$149+ Cheap flights from Greenville to San Diego (GSP - SAN)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/16. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — SAN
Oct 18 — Oct 251
Round-trip
1 adult, Economy
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Find cheap flights from Greenville to San Diego with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Greenville to San Diego
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Cheapest flights from Greenville to San DiegoExplore the most affordable flight options available from Greenville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
Explore the most affordable flight options available from Greenville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 18, 2026.
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:10 pm -
1 stop8h 27m
Tue 10/139:25 pm -
1 stop7h 59m
Deal found 9/16![American Airlines logo]()
$267
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/1412:50 pm -
1 stop10h 35m
Tue 11/177:10 am -
2 stops8h 00m
Deal found 9/16![Southwest logo]()
$272
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:05 am -
2 stops7h 45m
Wed 12/169:15 am -
2 stops8h 30m
Deal found 9/16![Southwest logo]()
$277
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/45:17 pm -
1 stop7h 33m
Mon 11/910:20 pm -
1 stop9h 02m
Deal found 9/16![American Airlines logo]()
$285
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/81:37 pm -
1 stop10h 08m
Wed 12/167:15 am -
1 stop6h 12m
Deal found 9/16![American Airlines logo]()
$291
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:20 am -
1 stop10h 00m
Mon 11/99:50 pm -
1 stop8h 57m
Deal found 9/18![Delta logo]()
$299
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:45 pm -
1 stop7h 25m
Mon 12/76:35 am -
1 stop10h 15m
Deal found 9/17![Southwest logo]()
$303
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:15 am -
1 stop9h 54m
Fri 10/910:25 pm -
1 stop8h 36m
Deal found 9/15![Delta logo]()
$321
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:45 pm -
1 stop7h 25m
Tue 12/87:05 am -
1 stop8h 05m
Deal found 9/13![Southwest logo]()
$339
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:25 pm -
1 stop9h 13m
Tue 11/249:45 pm -
1 stop7h 29m
Deal found 9/16![American Airlines logo]()
$341
Best flights from Greenville to San DiegoDiscover carefully curated flight deals from Greenville to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
Discover carefully curated flight deals from Greenville to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 18, 2026.
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/87:05 am -
2 stops7h 45m
Tue 12/156:35 am -
1 stop10h 15m
Deal found 9/15![Southwest logo]()
$272
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/47:20 am -
1 stop10h 00m
Mon 11/99:50 pm -
1 stop8h 57m
Deal found 9/18![Delta logo]()
$299
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:20 am -
2 stops12h 34m
Mon 11/910:30 pm -
1 stop8h 21m
Deal found 9/16![United Airlines logo]()
$400
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:45 pm -
1 stop7h 25m
Tue 12/87:05 am -
1 stop8h 05m
Deal found 9/13![Southwest logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/276:20 am -
2 stops9h 36m
Sat 10/316:45 am -
2 stops11h 13m
Deal found 9/17![United Airlines logo]()
$431
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/32:50 pm -
1 stop9h 10m
Sun 12/68:20 am -
2 stops8h 50m
Deal found 9/16![Southwest logo]()
$395
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:30 am -
2 stops12h 30m
Tue 12/157:41 pm -
3 stops15h 47m
Deal found 9/15![United Airlines logo]()
$450
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/77:20 pm -
1 stop6h 50m
Mon 10/129:50 am -
2 stops10h 00m
Deal found 9/14![Southwest logo]()
$455
Last-minute flights from Greenville to San DiegoDiscover last-minute flight deals from Greenville to San Diego. Data last updated September 18, 2026 and is based on user searches.
Discover last-minute flight deals from Greenville to San Diego. Data last updated September 18, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/57:15 am -
1 stop9h 54m
Fri 10/910:25 pm -
1 stop8h 36m
Deal found 9/15![Delta logo]()
$321
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:15 pm -
1 stop7h 09m
Fri 10/910:30 pm -
1 stop8h 28m
Deal found 9/17![United Airlines logo]()
$373
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/74:10 pm -
1 stop8h 27m
Tue 10/139:25 pm -
1 stop7h 59m
Deal found 9/16![American Airlines logo]()
$267
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/215:25 pm -
1 stop9h 13m
Tue 11/249:45 pm -
1 stop7h 29m
Deal found 9/16![American Airlines logo]()
$341
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/234:10 pm -
1 stop8h 27m
Tue 11/249:45 pm -
1 stop7h 29m
Deal found 9/16![American Airlines logo]()
$371
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/245:35 pm -
1 stop7h 55m
Tue 10/279:15 am -
2 stops8h 50m
Deal found 9/15![Southwest logo]()
$272
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/274:29 pm -
1 stop7h 07m
Sat 10/319:45 pm -
1 stop10h 17m
Deal found 9/15![United Airlines logo]()
$377
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/302:10 pm -
1 stop8h 05m
Sun 11/19:55 pm -
1 stop9h 15m
Deal found 9/17![Southwest logo]()
$399
One-way flights from Greenville to San DiegoSearch for one-way flight options from Greenville to San Diego. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
Search for one-way flight options from Greenville to San Diego. Find affordable one-way fares based on user searches. Data last updated September 18, 2026.
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/165:40 am -
1 stop7h 16m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Delta logo]()
$149
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/54:25 pm -
1 stop9h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![United Airlines logo]()
$152
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:32 pm -
2 stops22h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Multiple Airlines logo]()
$174
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:05 am -
2 stops9h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Southwest logo]()
$180
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/28:52 pm -
3 stops30h 05m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$187
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:30 am -
2 stops9h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![United Airlines logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/189:44 am -
3 stops57h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$210
Find flight deals from Greenville to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 18, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $267 (American Airlines) |
One-way from | $149 (Delta) |
Popular in | September |
Cheapest in | August |
Average price | $588 |
Cheapflights Fare Finder
Customize your flight search to find flights from Greenville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
Use the filters below to find and compare flights from Greenville to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GreenvilleSan Diego
GSP Greenville - SAN San Diego
GSPSAN
Greenville
Wed 12/16
10:27 am-4:28 pm
1 stop9h 01m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$149
GreenvilleSan Diego
GSP Greenville - SAN San Diego
GSPSAN
Greenville
Mon 10/5
8:32 pm-3:59 pm
2 stops22h 27m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$174
GreenvilleSan Diego
GSP Greenville - SAN San Diego
GSPSAN
Greenville
Thu 12/3
7:05 am-1:30 pm
2 stops9h 25m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$180
Quickest round-trip
GreenvilleSan Diego
GSP Greenville - SAN San Diego
GSPSAN
Greenville
Wed 12/16
3:26 pm-8:45 pm
1 stop8h 19m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$206
GreenvilleSan Diego
GSP Greenville - SAN San Diego
GSPSAN
Greenville
Mon 11/2
8:32 pm-11:57 pm
2 stops30h 25m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$206
GreenvilleSan Diego
GSP Greenville - SAN San Diego
GSPSAN
Greenville
Wed 12/16
6:30 am-1:13 pm
2 stops9h 43m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$209
GreenvilleSan Diego
GSP Greenville - SAN San Diego
GSPSAN
Greenville
Sun 10/18
9:44 am-3:58 pm
3 stops57h 14m
San Diego
Wed 12/31
12:00 am-3:00 am
Nonstop0h 00m
$210
GreenvilleSan Diego
GSP Greenville - SAN San Diego
GSPSAN
Greenville
Tue 12/8
7:05 am-11:50 am
2 stops7h 45m
San Diego
Tue 12/15
6:35 am-7:50 pm
1 stop10h 15m
$272
GreenvilleSan Diego
GSP Greenville - SAN San Diego
GSPSAN
Greenville
Wed 11/4
7:20 am-2:20 pm
1 stop10h 00m
San Diego
Mon 11/9
9:50 pm-9:47 am
1 stop8h 57m
$299
GreenvilleSan Diego
GSP Greenville - SAN San Diego
GSPSAN
Greenville
Tue 12/1
6:45 pm-11:10 pm
1 stop7h 25m
San Diego
Tue 12/8
7:05 am-6:10 pm
1 stop8h 05m
$339
Showing 1-10 of 15 resultsSorted by cheapest first
Compare providers for flights from Greenville to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to San Diego in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Greenville-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Greenville-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Greenville-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Greenville-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Greenville to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Greenville with our price prediction graph.
GSP-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Greenville to San Diego
How far ahead should I book a flight from Greenville to San Diego?
The price you pay for your flight from Greenville to San Diego may vary depending on when you book. For the best chance of a lower fare, look to book 44 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Greenville to San Diego?
Currently, August is the cheapest month in which you can book a flight from Greenville to San Diego (average of $362). Flying from Greenville to San Diego in September is currently the most expensive (average of $588). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Greenville to San Diego?
Airfare is below average for this route at the moment.
Greenville to San Diego flights typically cost between $452 and $622 in October.The cheapest round-trip price found within the last 5 days was $267 on American Airlines (Oct 7-Oct 13).
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated September 18, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Greenville to San Diego to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Comfort
8.0
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Comfort
8.0
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Comfort
8.0
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Comfort
8.0
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Entertainment
7.5
Comfort
8.0
Food
7.0
Overall
8.0
Boarding
8.1
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Greenville to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
Chula Vista
Coronado
San Ysidro
Poway
La Mesa
Santee
Julian
Lemon Grove
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Greenville and San Diego flights
Browse other Greenville and San Diego flight options. Last updated on September 18, 2026.
Other flights from Greenville
Browse through other flights departing from Greenville. Flights are based on user searches made on Cheapflights and were last updated on September 18, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Diego
Explore flights to San Diego departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 18, 2026.
Top 4 airlines flying from Greenville to San Diego
Discover the top 4 airlines that operate flights from Greenville to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 18, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$312 | Average$466 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$324 | Average$511 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$326 | Average$506 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$326 | Average$506 | FlexibilityNo cancel fee | On-timeN/A |