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$219+ Cheap flights from Greenville to San Diego (GSP - SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/1. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — SAN
Dec 16 — Dec 231
Tue 12/16
Tue 12/23
1 adult, Economy
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Cheapflights Tip: The best prices from Greenville to San Diego are usually found in July or October, booked 57 days in advance, depart on a Friday or Thursday and return on a Wednesday

Find flight deals from Greenville to San Diego

Cheapest flights from Greenville to San Diego
Explore the most affordable flight options available from Greenville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 16, 2025.

This Delta deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1710:08 amGSP - SAN
1 stop8h 13mDelta
Wed 12/2410:30 pmSAN - GSP
1 stop7h 49mDelta
Deal found 11/14$368
This American Airlines deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:00 amGSP - SAN
1 stop11h 16mAmerican Airlines
Mon 12/156:15 amSAN - GSP
1 stop12h 46mAmerican Airlines
Deal found 11/14$375
This Delta deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/107:25 amGSP - SAN
1 stop9h 47mDelta
Wed 12/1710:30 pmSAN - GSP
1 stop7h 32mDelta
Deal found 11/14$377
This American Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:00 amGSP - SAN
1 stop11h 13mAmerican Airlines
Wed 1/76:20 amSAN - GSP
1 stop14h 39mAmerican Airlines
Deal found 11/16$396
This Delta deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/185:35 amGSP - SAN
1 stop7h 19mDelta
Wed 12/2410:30 pmSAN - GSP
1 stop7h 49mDelta
Deal found 11/14$403
This American Airlines deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/86:00 amGSP - SAN
1 stop11h 16mAmerican Airlines
Tue 12/96:15 amSAN - GSP
1 stop6h 19mAmerican Airlines
Deal found 11/14$405
This American Airlines deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/56:00 amGSP - SAN
1 stop11h 16mAmerican Airlines
Sun 12/76:15 amSAN - GSP
1 stop10h 29mAmerican Airlines
Deal found 11/14$410
This Southwest deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/107:40 amGSP - SAN
1 stop10h 35mSouthwest
Wed 12/178:05 pmSAN - GSP
2 stops10h 40mSouthwest
Deal found 11/14$417
This American Airlines deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/311:42 amGSP - SAN
1 stop12h 03mAmerican Airlines
Sun 12/76:15 amSAN - GSP
1 stop10h 29mAmerican Airlines
Deal found 11/15$422
This United Airlines deal was found by Cheapflights users on 11/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/710:00 amGSP - SAN
1 stop8h 28mUnited Airlines
Wed 12/1710:52 amSAN - GSP
1 stop6h 57mUnited Airlines
Deal found 11/14$448
This Southwest deal was found by Cheapflights users on 11/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/33:05 pmGSP - SAN
1 stop6h 50mSouthwest
Sun 12/77:45 amSAN - GSP
2 stops8h 40mSouthwest
Deal found 11/15$453

Cheap flight deals from Greenville to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 16, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$367
(Delta)

One-way from

$224
(American Airlines)

Popular in

December

Cheapest in

July

Average price

$477
Provider with most accurate pricing for Greenville-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-San Diego flights.
Search Deals
From Greenville to San Diego
Search Deals
One-way flight from Greenville to San Diego
Search Deals
Highest demand for flights based on searches. 13% potential increase in price ($69 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 16, 2025.
Use the filters below to find and compare flights from Greenville to San Diego that are best for you.

Fly from

Greenville

Fly to

San Diego

Route

Depart

Return

Price

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Tue 3/10

5:45 am-10:20 am

1 stop7h 35m

San Diego

Wed 3/11

11:50 am-10:05 pm

1 stop7h 15m

$367

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Wed 12/17

10:08 am-3:21 pm

1 stop8h 13m

San Diego

Wed 12/24

10:30 pm-9:19 am

1 stop7h 49m

$368

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Thu 2/19

2:31 pm-7:20 pm

1 stop7h 49m

San Diego

Sun 2/22

10:05 pm-8:38 am

1 stop7h 33m

$403

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Sat 2/21

2:10 pm-10:30 pm

1 stop11h 20m

San Diego

Sat 3/7

6:30 am-5:25 pm

1 stop7h 55m

$403

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Sun 1/18

6:35 am-12:59 pm

2 stops9h 24m

San Diego

Fri 1/23

10:52 am-8:47 pm

1 stop6h 55m

$408

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Wed 12/10

7:40 am-3:15 pm

1 stop10h 35m

San Diego

Wed 12/17

8:05 pm-9:45 am

2 stops10h 40m

$417

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Wed 1/7

6:00 am-11:36 am

2 stops8h 36m

San Diego

Mon 1/12

10:09 am-8:56 pm

2 stops7h 47m

$422

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Sun 2/8

12:09 pm-6:35 pm

2 stops9h 26m

San Diego

Wed 2/11

10:09 am-8:56 pm

2 stops7h 47m

$422

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Thu 2/5

12:09 pm-6:35 pm

2 stops9h 26m

San Diego

Fri 2/6

6:20 am-11:59 pm

1 stop14h 39m

$445

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Sat 5/2

5:45 am-10:01 am

1 stop7h 16m

San Diego

Thu 5/14

11:00 am-9:25 pm

1 stop7h 25m

$447

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/15

Showing 1-10 of 22 results
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2
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Compare providers for flights from Greenville to San Diego

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Greenville to San Diego in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
PricelinePrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Greenville-San Diego flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Greenville-San Diego flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Greenville-San Diego flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Greenville-San Diego flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Greenville-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Greenville to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to San Diego

How far ahead should I book a flight from Greenville to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Greenville to San Diego. Price data was last updated on November 14, 2025.

The price you pay for your flight from Greenville to San Diego may vary depending on when you book. For the best chance of a lower fare, look to book 57 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Greenville to San Diego?

Currently, June is the cheapest month in which you can book a flight from Greenville to San Diego (average of $105). Flying from Greenville to San Diego in December is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to SAN?

Find hourly flight availability from Greenville to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 16, 2025.

It’s typically best to fly out from Greenville to San Diego in the evening. Doing so could potentially save you 9% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated November 16, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Greenville to San Diego to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,244 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,244 reviews
Southwest
8.0
Very good
4,244 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
7.9
Good
8,007 reviews
Southwest
8.0
Very good
4,244 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
9,015 reviews
Southwest
8.0
Very good
4,244 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
11,050 reviews
Southwest
8.0
Very good
4,244 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Greenville to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to San Diego?

    There are many flights that can get you from Greenville to San Diego in 7h 35m. Fly via Delta, American Airlines, or Southwest to get the fastest option. Greenville and San Diego are separated by a distance of 2002 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Greenville to San Diego round-trip?

    Cheapflights users have booked flights from Greenville to San Diego round-trip from $284. Other airlines that can offer you cheap pricing are American Airlines, from $291, and United Airlines, from $312. These flights start at 33% lower than the current average price 3 months from now.

  • Can I find deals for flights from Greenville to San Diego that include hotel bookings?

    Yes. In addition to deals on Greenville to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to San Diego.

  • Can I find deals for business class flights from Greenville to San Diego?

    Yes. Cheapflights offers flight deals from Greenville to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to San Diego?

    Currently, June is the cheapest month in which you can book a flight from Greenville to San Diego (average of $105). Flying from Greenville to San Diego in December is currently the most expensive (average of $258). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
Coronado
La Mesa
Poway
Lemon Grove
National City

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Top 4 airlines flying from Greenville to San Diego

Discover the top 4 airlines that operate flights from Greenville to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$284Average$420FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$291Average$430FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$312Average$500FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$350Average$482FlexibilityNo cancel feeOn-time63%

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