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$161+ Cheap flights from Greenville to San Diego (GSP - SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/6. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — SAN
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from Greenville to San Diego are usually found in July or October, booked 57 days in advance, depart on a Friday or Thursday and return on a Wednesday

Cheap flight deals from Greenville to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Greenville (GSP) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$337
(American Airlines)

One-way from

$161
(Kiwi.com)

Popular in

March

Cheapest in

July

Average price

$436
From Greenville to San Diego
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One-way flight from Greenville to San Diego
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Highest demand for flights based on searches. 3% potential increase in price ($15 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Greenville to San Diego

Cheapest flights from Greenville to San Diego
Explore the most affordable flight options available from Greenville to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/154:46 pmGSP - SAN
1 stop8h 36mAmerican Airlines
Wed 10/221:16 pmSAN - GSP
1 stop6h 36mAmerican Airlines
Deal found 9/15$337
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/112:53 pmGSP - SAN
1 stop8h 53mAmerican Airlines
Wed 11/56:19 amSAN - GSP
1 stop10h 41mAmerican Airlines
Deal found 9/15$339
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2811:26 amGSP - SAN
1 stop10h 57mAmerican Airlines
Fri 10/3112:30 pmSAN - GSP
1 stop7h 51mAmerican Airlines
Deal found 9/16$348
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/13:35 pmGSP - SAN
2 stops8h 25mSouthwest
Wed 11/56:50 amSAN - GSP
1 stop10h 00mSouthwest
Deal found 9/15$353
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/105:00 amGSP - SAN
1 stop7h 09mAmerican Airlines
Tue 10/149:26 pmSAN - GSP
1 stop9h 17mAmerican Airlines
Deal found 9/15$358
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/164:46 pmGSP - SAN
1 stop8h 36mAmerican Airlines
Mon 10/209:27 pmSAN - GSP
1 stop9h 16mAmerican Airlines
Deal found 9/15$359
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/253:35 pmGSP - SAN
2 stops8h 25mSouthwest
Mon 11/39:45 pmSAN - GSP
1 stop9h 15mSouthwest
Deal found 9/16$364
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/113:05 pmGSP - SAN
2 stops9h 05mSouthwest
Tue 12/165:15 pmSAN - GSP
2 stops13h 45mSouthwest
Deal found 9/15$368
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/105:00 amGSP - SAN
1 stop9h 27mAmerican Airlines
Fri 11/1410:23 pmSAN - GSP
1 stop7h 12mAmerican Airlines
Deal found 9/16$369
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/248:25 amGSP - SAN
1 stop12h 10mSouthwest
Mon 10/277:35 pmSAN - GSP
2 stops11h 25mSouthwest
Deal found 9/15$380
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/25:00 amGSP - SAN
1 stop9h 27mAmerican Airlines
Wed 11/56:19 amSAN - GSP
1 stop10h 41mAmerican Airlines
Deal found 9/15$383

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Greenville to San Diego that are best for you.

Fly from

Greenville

Fly to

San Diego

Route

Depart

Return

Price

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Sat 11/1

12:53 pm-6:46 pm

1 stop8h 53m

San Diego

Wed 11/5

6:19 am-8:00 pm

1 stop10h 41m

$339

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Sat 10/25

11:26 am-7:29 pm

1 stop11h 03m

San Diego

Mon 11/3

12:27 pm-11:59 pm

1 stop8h 32m

$348

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Tue 10/28

11:26 am-7:23 pm

1 stop10h 57m

San Diego

Fri 10/31

12:30 pm-11:21 pm

1 stop7h 51m

$348

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Thu 12/11

3:05 pm-6:55 pm

1 stop6h 50m

San Diego

Tue 12/16

6:40 pm-10:00 am

2 stops12h 20m

$353

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Thu 1/15

4:50 pm-9:56 pm

1 stop8h 06m

San Diego

Mon 1/19

8:37 pm-10:16 am

2 stops10h 39m

$364

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Sat 10/25

3:35 pm-9:00 pm

2 stops8h 25m

San Diego

Mon 11/3

9:45 pm-10:00 am

1 stop9h 15m

$364

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Fri 11/7

4:15 pm-8:25 pm

1 stop7h 10m

San Diego

Mon 11/10

9:45 pm-10:00 am

1 stop9h 15m

$369

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Mon 11/10

5:00 am-11:27 am

1 stop9h 27m

San Diego

Fri 11/14

10:23 pm-8:35 am

1 stop7h 12m

$369

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Fri 10/24

8:25 am-5:35 pm

1 stop12h 10m

San Diego

Mon 10/27

7:35 pm-10:00 am

2 stops11h 25m

$380

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Wed 10/22

7:30 am-2:32 pm

1 stop10h 02m

San Diego

Sun 10/26

10:30 pm-8:59 am

1 stop7h 29m

$392

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 20 results
1
2

Best time to book a flight from Greenville to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to San Diego

How far ahead should I book a flight from Greenville to San Diego?

Use this chart to determine the optimal time to book a round-trip flight from Greenville to San Diego. Price data was last updated on September 12, 2025.

The price you pay for your flight from Greenville to San Diego may vary depending on when you book. For the best chance of a lower fare, look to book 57 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Greenville to San Diego?

Currently, August is the cheapest month in which you can book a flight from Greenville to San Diego (average of $286). Flying from Greenville to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to SAN?

Find hourly flight availability from Greenville to San Diego. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

It’s typically best to fly out from Greenville to San Diego in the evening. Doing so could potentially save you 10% on the flight price compared to flying at noon, which is usually more expensive.

Reviews of airlines servicing San Diego

Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated September 17, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Greenville to San Diego to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Crew

8.6

Food

7.0

Overall

8.0

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Crew

8.6

Food

7.0

Overall

8.0

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
8.0
Very good
7,961 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Crew

8.6

Food

7.0

Overall

8.0

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
8,926 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Crew

8.6

Food

7.0

Overall

8.0

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Crew

8.6

Food

7.0

Overall

8.0

Entertainment

7.5

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Greenville to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Greenville to San Diego?

    There are many flights that can get you from Greenville to San Diego in 6h 50m. Fly via American Airlines or Southwest to get the fastest option. Greenville and San Diego are separated by a distance of 2002 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Greenville to San Diego round-trip?

    Cheapflights users have booked flights from Greenville to San Diego round-trip from $284. Other airlines that can offer you cheap pricing are American Airlines, from $292, and United Airlines, from $321. These flights start at 34% lower than the current average price 3 months from now.

  • Can I find deals for flights from Greenville to San Diego that include hotel bookings?

    Yes. In addition to deals on Greenville to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to San Diego.

  • Can I find deals for business class flights from Greenville to San Diego?

    Yes. Cheapflights offers flight deals from Greenville to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Greenville to San Diego (average of $286). Flying from Greenville to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
La Mesa
Poway
Lemon Grove
Coronado
Imperial Beach
National City

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Top 4 airlines flying from Greenville to San Diego

Discover the top 4 airlines that operate flights from Greenville to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$284Average$427FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$292Average$437FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$321Average$507FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$350Average$467FlexibilityNo cancel feeOn-time63%

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