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$532+ Cheap flights from Florence, SC to San Diego (FLO - SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/22. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — SAN
May 12 — May 191
Tue 5/12
Tue 5/19
1 adult, Economy
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Cheap flight deals from Florence to San Diego

Cheapest flights from Florence to San Diego
Explore the most affordable flight options available from Florence to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 12, 2026.

This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:15 am
FLO
-
SAN
2 stops15h 13m
American Airlines
Sat 5/96:15 am
SAN
-
FLO
2 stops12h 32m
American Airlines
Deal found 4/8$564
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/154:16 pm
FLO
-
SAN
1 stop7h 34m
American Airlines
Mon 5/1812:03 pm
SAN
-
FLO
1 stop6h 44m
American Airlines
Deal found 4/8$579
This American Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/2612:51 pm
FLO
-
SAN
1 stop9h 05m
American Airlines
Sat 1/26:15 am
SAN
-
FLO
1 stop8h 50m
American Airlines
Deal found 4/11$853
This American Airlines deal was found by Cheapflights users on 4/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/75:14 am
FLO
-
SAN
1 stop8h 25m
American Airlines
Mon 9/710:30 pm
SAN
-
FLO
1 stop9h 20m
American Airlines
Deal found 4/11$1,147

Find flight deals from Florence to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$564
(American Airlines)

One-way from

$532
(American Airlines)
Provider with most accurate pricing for Florence-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Florence-San Diego flights.
Search Deals
From Florence to San Diego
Search Deals
One-way flight from Florence to San Diego
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 12, 2026.
Use the filters below to find and compare flights from Florence to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Tue 5/5

6:15 am-6:28 pm

2 stops15h 13m

San Diego

Sat 5/9

6:15 am-9:47 pm

2 stops12h 32m

$564
Quickest round-trip

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Fri 5/15

4:16 pm-8:50 pm

1 stop7h 34m

San Diego

Mon 5/18

12:03 pm-9:47 pm

1 stop6h 44m

$579

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Mon 9/7

5:14 am-10:39 am

1 stop8h 25m

San Diego

Mon 9/7

10:30 pm-10:50 am

1 stop9h 20m

$1,147
Cheapest one-way

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Wed 7/22

2:35 pm-6:47 pm

1 stop7h 12m

$532
Quickest one-way

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Tue 7/21

5:17 am-9:00 am

1 stop6h 43m

$532

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Sat 7/18

5:17 am-9:00 am

1 stop6h 43m

$532

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Mon 7/20

2:35 pm-6:28 pm

2 stops30h 53m

$566

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Fri 7/24

5:17 am-2:17 pm

2 stops12h 00m

$582

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Thu 7/23

2:35 pm-10:37 pm

2 stops11h 02m

$629

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/7

Sorted by cheapest first

Compare providers for flights from Florence to San Diego

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Florence to San Diego in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Florence, South Carolina-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Florence, South Carolina-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Florence, South Carolina-San Diego flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Florence, South Carolina-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Florence, South Carolina-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Florence to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to San Diego

What is the cheapest month to book a flight from Florence, South Carolina to San Diego?

Currently, March is the cheapest month in which you can book a flight from Florence, South Carolina to San Diego (average of $96). Flying from Florence, South Carolina to San Diego in January is currently the most expensive (average of $266). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Florence to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Florence, South Carolina to San Diego?

    American Airlines can get you from Florence, South Carolina to San Diego in just under 15h 13m. Your travel time can differ by up to . The distance between Florence, South Carolina and San Diego is about 2149 mi.

  • Can I find deals for flights from Florence to San Diego that include hotel bookings?

    Yes. In addition to deals on Florence to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to San Diego.

  • Can I find deals for business class flights from Florence to San Diego?

    Yes. Cheapflights offers flight deals from Florence to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to San Diego?

    Currently, March is the cheapest month in which you can book a flight from Florence, South Carolina to San Diego (average of $96). Flying from Florence, South Carolina to San Diego in January is currently the most expensive (average of $266). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
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Coronado
La Mesa
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Julian
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