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$510+ Cheap flights from Florence, SC to San Diego (FLO - SAN)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/23. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — SAN
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheap flight deals from Florence to San Diego

Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$510
(American Airlines)
From Florence to San Diego
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Find flight deals from Florence to San Diego

Cheapest flights from Florence to San Diego
Explore the most affordable flight options available from Florence to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/236:14 amFLO - SAN
1 stop7h 06mAmerican Airlines
Tue 9/306:20 amSAN - FLO
2 stops13h 56mAmerican Airlines
Deal found 9/9$510

Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Florence to San Diego that are best for you.

Fly from

Florence

Fly to

San Diego

Route

Depart

Return

Price

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Tue 9/23

6:14 am-10:20 am

1 stop7h 06m

San Diego

Tue 9/30

6:20 am-11:16 pm

2 stops13h 56m

$510

FlorenceSan Diego

FLO - SAN

FLOSAN

Florence

Tue 9/30

6:14 am-10:20 am

1 stop7h 06m

San Diego

Tue 10/7

6:15 am-11:13 pm

2 stops13h 58m

$510

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/9

Best time to book a flight from Florence to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to San Diego

What is the cheapest month to book a flight from Florence, South Carolina to San Diego?

Currently, August is the cheapest month in which you can book a flight from Florence, South Carolina to San Diego (average of $286). Flying from Florence, South Carolina to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Florence to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Florence, South Carolina to San Diego?

    American Airlines can get you from Florence, South Carolina to San Diego in just under 7h 06m. Your travel time can differ by up to . The distance between Florence, South Carolina and San Diego is about 2149 mi.

  • Can I find deals for flights from Florence to San Diego that include hotel bookings?

    Yes. In addition to deals on Florence to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to San Diego.

  • Can I find deals for business class flights from Florence to San Diego?

    Yes. Cheapflights offers flight deals from Florence to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to San Diego?

    Currently, August is the cheapest month in which you can book a flight from Florence, South Carolina to San Diego (average of $286). Flying from Florence, South Carolina to San Diego in March is currently the most expensive (average of $366). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
Chula Vista
La Mesa
Poway
Lemon Grove
Coronado
Imperial Beach
National City
Alpine

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