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$194+ Cheap flights from Des Moines to Panama City, FL (DSM - ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — ECP
Jan 22 — Jan 291
Thu 1/22
Thu 1/29
1 adult, Economy
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1. Tell us where you want to go

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Cheapflights Tip: The best prices from Des Moines to Panama City NW Florida Beaches are usually found in August or July, booked 69 days in advance, depart on a Tuesday or Monday and return on a Friday

Cheap flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 23, 2025.

This Delta deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/241:15 pmDSM - ECP
1 stop5h 00mDelta
Sun 12/286:00 amECP - DSM
1 stop4h 38mDelta
Deal found 12/22$687
This Southwest deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:35 amDSM - ECP
2 stops10h 45mSouthwest
Sat 1/312:10 pmECP - DSM
2 stops11h 45mSouthwest
Deal found 12/22$738
This United Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/223:14 pmDSM - ECP
2 stops30h 40mUnited Airlines
Wed 12/246:15 amECP - DSM
1 stop8h 04mUnited Airlines
Deal found 12/22$851
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/223:28 pmDSM - ECP
1 stop5h 56mAmerican Airlines
Wed 12/246:46 amECP - DSM
1 stop8h 12mAmerican Airlines
Deal found 12/22$862
This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/262:07 pmDSM - ECP
1 stop20h 34mAmerican Airlines
Sat 1/36:46 amECP - DSM
1 stop8h 12mAmerican Airlines
Deal found 12/22$1,076
This United Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/268:00 amDSM - ECP
3 stops25h 17mUnited Airlines
Sat 1/36:15 amECP - DSM
2 stops10h 10mUnited Airlines
Deal found 12/22$1,729

Find flight deals from Des Moines to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 23, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$274
(Delta)

One-way from

$194
(American Airlines)

Popular in

December

Cheapest in

August

Average price

$734
Provider with most accurate pricing for Des Moines-Panama City NW Florida Beaches flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Panama City NW Florida Beaches flights.
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From Des Moines to Panama City NW Florida Beaches
Search Deals
One-way flight from Des Moines to Panama City NW Florida Beaches
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($104 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($26 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Des Moines

Fly to

Panama City

Route

Depart

Return

Price

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 2/10

5:16 pm-10:40 pm

1 stop5h 24m

Panama City NW Florida Beaches

Wed 2/18

6:00 am-11:19 am

1 stop5h 19m

$294

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Sat 1/17

12:25 pm-10:51 pm

2 stops10h 26m

Panama City NW Florida Beaches

Tue 2/3

6:00 am-10:41 am

1 stop4h 41m

$299

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 1/13

4:21 pm-10:51 pm

2 stops6h 30m

Panama City NW Florida Beaches

Sat 1/17

7:20 am-12:15 pm

1 stop4h 55m

$299

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 2/10

7:43 am-5:33 pm

2 stops9h 50m

Panama City NW Florida Beaches

Wed 2/18

8:20 am-8:06 pm

2 stops11h 46m

$304

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 1/20

11:26 am-6:14 pm

1 stop6h 48m

Panama City NW Florida Beaches

Mon 2/2

6:09 pm-10:29 pm

1 stop4h 20m

$305

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Mon 1/12

12:04 pm-10:51 pm

2 stops10h 47m

Panama City NW Florida Beaches

Sat 1/17

7:20 am-12:15 pm

1 stop4h 55m

$310

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Mon 1/12

12:04 pm-10:51 pm

2 stops10h 47m

Panama City NW Florida Beaches

Tue 1/20

6:00 am-10:41 am

1 stop4h 41m

$310

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Sat 1/17

12:25 pm-10:51 pm

2 stops10h 26m

Panama City NW Florida Beaches

Sat 1/31

7:20 am-5:08 pm

2 stops9h 48m

$315

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Sun 2/8

6:00 am-1:04 pm

1 stop7h 04m

Panama City NW Florida Beaches

Sat 2/14

7:19 am-1:17 pm

1 stop5h 58m

$328

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Sun 1/18

1:03 pm-7:53 pm

1 stop6h 50m

Panama City NW Florida Beaches

Fri 1/30

3:45 pm-10:29 pm

1 stop6h 44m

$328

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/22

Showing 1-10 of 15 results
1
2

Compare providers for flights from Des Moines to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Panama City in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Panama City, Florida flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Panama City, Florida flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Panama City, Florida flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Panama City, Florida flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama City

How far ahead should I book a flight from Des Moines to Panama City, Florida?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Panama City. Price data was last updated on December 19, 2025.

The best time to book flights from Des Moines to Panama City, Florida is 69 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Des Moines to Panama City, Florida?

Currently, July is the cheapest month in which you can book a flight from Des Moines to Panama City, Florida (average of $108). Flying from Des Moines to Panama City, Florida in February is currently the most expensive (average of $286). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated December 23, 2025.
Read through reviews of airlines operating flights from Des Moines to Panama City, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,253 reviews

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,253 reviews
Southwest
8.0
Very good
4,253 reviews

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,014 reviews
Southwest
8.0
Very good
4,253 reviews

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,105 reviews
Southwest
8.0
Very good
4,253 reviews

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,054 reviews
Southwest
8.0
Very good
4,253 reviews

Entertainment

7.5

Boarding

8.1

Food

7.0

Comfort

8.0

Crew

8.6

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Panama City, Florida?

    Airlines like Delta and American Airlines fly from Des Moines to Panama City, Florida in about 5h 24m. The time it takes to get you to your destination can typically vary by up to 4h 26m. There are 887 mi between Des Moines and Panama City, Florida. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Des Moines to Panama City, Florida round-trip?

    Cheapflights users have booked flights from Des Moines to Panama City, Florida round-trip from $239. Other airlines that can offer you cheap pricing are American Airlines, from $283, and United Airlines, from $296. Delta is priced at 46% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.

  • Can I find deals for business class flights from Des Moines to Panama City?

    Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama City, Florida?

    Currently, July is the cheapest month in which you can book a flight from Des Moines to Panama City, Florida (average of $108). Flying from Des Moines to Panama City, Florida in February is currently the most expensive (average of $286). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
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Top 4 airlines flying from Des Moines to Panama City

Discover the top 4 airlines that operate flights from Des Moines to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 23, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$239Average$429FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$283Average$379FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$296Average$638FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$302Average$396FlexibilityNo cancel feeOn-time63%

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