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$178+ Cheap flights from Des Moines to Panama City, FL (DSM - ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/4. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — ECP
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Panama City NW Florida Beaches are usually found in August or July, booked 69 days in advance, depart on a Tuesday or Monday and return on a Friday

Find flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/162:53 pmDSM - ECP
1 stop6h 56mUnited Airlines
Sat 12/202:10 pmECP - DSM
1 stop7h 30mUnited Airlines
Deal found 11/4$353
This Southwest deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/166:15 amDSM - ECP
2 stops9h 35mSouthwest
Sat 12/2012:05 pmECP - DSM
2 stops11h 50mSouthwest
Deal found 11/4$373
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/215:35 amDSM - ECP
1 stop4h 51mDelta
Tue 11/256:00 amECP - DSM
1 stop4h 42mDelta
Deal found 11/5$467
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/216:00 amDSM - ECP
1 stop6h 49mAmerican Airlines
Tue 11/257:15 amECP - DSM
2 stops11h 11mAmerican Airlines
Deal found 11/5$472
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2511:32 amDSM - ECP
1 stop7h 23mAmerican Airlines
Thu 1/17:15 amECP - DSM
1 stop6h 06mAmerican Airlines
Deal found 11/5$524
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2511:32 amDSM - ECP
1 stop7h 23mAmerican Airlines
Fri 1/27:15 amECP - DSM
1 stop6h 06mAmerican Airlines
Deal found 11/5$738
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/277:00 amDSM - ECP
2 stops9h 50mSouthwest
Sat 1/312:10 pmECP - DSM
2 stops13h 10mSouthwest
Deal found 11/5$813

Cheap flight deals from Des Moines to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 6, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$337
(Delta)

One-way from

$157
(United Airlines)

Popular in

March

Cheapest in

August

Average price

$462
Provider with most accurate pricing for Des Moines-Panama City NW Florida Beaches flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Panama City NW Florida Beaches flights.
Search Deals
From Des Moines to Panama City NW Florida Beaches
Search Deals
One-way flight from Des Moines to Panama City NW Florida Beaches
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($76 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($26 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Des Moines

Fly to

Panama City

Route

Depart

Return

Price

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 1/27

11:26 am-6:14 pm

1 stop6h 48m

Panama City NW Florida Beaches

Mon 2/2

6:09 pm-10:31 pm

1 stop4h 22m

$337

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Fri 1/16

4:00 pm-9:19 pm

1 stop5h 19m

Panama City NW Florida Beaches

Tue 1/20

6:03 pm-11:08 pm

1 stop5h 05m

$350

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 12/16

2:53 pm-9:49 pm

1 stop6h 56m

Panama City NW Florida Beaches

Sat 12/20

2:10 pm-9:40 pm

1 stop7h 30m

$353

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Wed 1/28

4:00 pm-9:19 pm

1 stop5h 19m

Panama City NW Florida Beaches

Sun 2/1

1:34 pm-10:11 pm

1 stop8h 37m

$353

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Mon 1/26

5:16 pm-10:40 pm

1 stop5h 24m

Panama City NW Florida Beaches

Mon 2/2

12:58 pm-7:34 pm

1 stop6h 36m

$355

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Thu 12/4

8:15 am-1:58 pm

1 stop5h 43m

$178

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/5

Compare providers for flights from Des Moines to Panama City

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Panama City in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Panama City, Florida flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Panama City, Florida flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Panama City, Florida flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Panama City, Florida flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama City

How far ahead should I book a flight from Des Moines to Panama City, Florida?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Panama City. Price data was last updated on October 31, 2025.

The best time to book flights from Des Moines to Panama City, Florida is 69 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Des Moines to Panama City, Florida?

Currently, July is the cheapest month in which you can book a flight from Des Moines to Panama City, Florida (average of $108). Flying from Des Moines to Panama City, Florida in February is currently the most expensive (average of $286). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated November 6, 2025.
Read through reviews of airlines operating flights from Des Moines to Panama City, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,241 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
7.9
Good
8,001 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
9,007 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
11,040 reviews
Southwest
8.0
Very good
4,241 reviews

Overall

8.0

Entertainment

7.5

Boarding

8.1

Crew

8.6

Food

7.0

Comfort

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Panama City, Florida?

    Airlines like Delta fly from Des Moines to Panama City, Florida in about 6h 48m. The time it takes to get you to your destination can typically vary by up to . There are 887 mi between Des Moines and Panama City, Florida.

  • What are the cheapest airlines flying from Des Moines to Panama City, Florida round-trip?

    Cheapflights users have booked flights from Des Moines to Panama City, Florida round-trip from $239. Other airlines that can offer you cheap pricing are American Airlines, from $283, and United Airlines, from $296. Delta is priced at 47% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.

  • Can I find deals for business class flights from Des Moines to Panama City?

    Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama City, Florida?

    Currently, July is the cheapest month in which you can book a flight from Des Moines to Panama City, Florida (average of $108). Flying from Des Moines to Panama City, Florida in February is currently the most expensive (average of $286). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

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Top 4 airlines flying from Des Moines to Panama City

Discover the top 4 airlines that operate flights from Des Moines to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$239Average$437FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$283Average$384FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$296Average$592FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$302Average$409FlexibilityNo cancel feeOn-time63%

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