$168+ Cheap flights from Des Moines to Panama City, FL (DSM - ECP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/5. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — ECP
May 8 — May 151
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to Panama CityExplore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 8, 2026.
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 8, 2026.
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/32:33 pm
DSM
- ECP
1 stop4h 03m
Delta
Wed 6/101:31 pm
ECP
- DSM
1 stop4h 23m
Delta
Deal found 4/6![Delta logo]()
$335
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/35:30 am
DSM
- ECP
2 stops10h 50m
Southwest
Wed 6/108:05 am
ECP
- DSM
1 stop7h 00m
Southwest
Deal found 4/5![Southwest logo]()
$340
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/164:00 pm
DSM
- ECP
1 stop6h 51m
Delta
Tue 5/191:50 pm
ECP
- DSM
1 stop4h 03m
Delta
Deal found 4/5![Delta logo]()
$355
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/31:48 pm
DSM
- ECP
2 stops9h 52m
American Airlines
Wed 6/106:45 pm
ECP
- DSM
1 stop5h 25m
American Airlines
Deal found 4/6![American Airlines logo]()
$360
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/42:16 pm
DSM
- ECP
2 stops9h 30m
American Airlines
Tue 5/1211:43 am
ECP
- DSM
2 stops12h 06m
American Airlines
Deal found 4/4![American Airlines logo]()
$365
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/811:57 am
DSM
- ECP
1 stop4h 07m
Delta
Tue 5/126:00 am
ECP
- DSM
1 stop5h 08m
Delta
Deal found 4/4![Delta logo]()
$371
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:25 am
DSM
- ECP
1 stop6h 10m
Southwest
Mon 5/115:00 pm
ECP
- DSM
1 stop6h 05m
Southwest
Deal found 4/6![Southwest logo]()
$375
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:00 am
DSM
- ECP
1 stop6h 36m
American Airlines
Tue 5/127:21 am
ECP
- DSM
2 stops9h 10m
American Airlines
Deal found 4/5![American Airlines logo]()
$376
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/238:43 am
DSM
- ECP
2 stops9h 43m
American Airlines
Sat 5/303:48 pm
ECP
- DSM
1 stop6h 17m
American Airlines
Deal found 4/6![American Airlines logo]()
$380
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:40 am
DSM
- ECP
2 stops7h 50m
Southwest
Sat 5/99:55 am
ECP
- DSM
2 stops11h 00m
Southwest
Deal found 4/6![Southwest logo]()
$385
Best flights from Des Moines to Panama CityDiscover carefully curated flight deals from Des Moines to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 8, 2026.
Discover carefully curated flight deals from Des Moines to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 8, 2026.
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/164:00 pm
DSM
- ECP
1 stop6h 51m
Delta
Tue 5/191:50 pm
ECP
- DSM
1 stop4h 03m
Delta
Deal found 4/5![Delta logo]()
$355
This American Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:02 am
DSM
- ECP
1 stop6h 43m
American Airlines
Wed 7/810:06 am
ECP
- DSM
1 stop5h 54m
American Airlines
Deal found 4/3![American Airlines logo]()
$371
This Southwest deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:25 am
DSM
- ECP
1 stop6h 10m
Southwest
Mon 5/115:00 pm
ECP
- DSM
1 stop6h 05m
Southwest
Deal found 4/3![Southwest logo]()
$375
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:38 pm
DSM
- ECP
1 stop4h 59m
Delta
Wed 8/127:45 am
ECP
- DSM
1 stop5h 37m
Delta
Deal found 4/5![Delta logo]()
$371
This Southwest deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/195:10 am
DSM
- ECP
1 stop5h 40m
Southwest
Tue 6/237:00 am
ECP
- DSM
2 stops8h 05m
Southwest
Deal found 4/7![Southwest logo]()
$376
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:00 am
DSM
- ECP
1 stop6h 36m
American Airlines
Tue 5/1211:43 am
ECP
- DSM
2 stops11h 33m
American Airlines
Deal found 4/4![American Airlines logo]()
$376
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/42:33 pm
DSM
- ECP
1 stop4h 36m
Delta
Tue 6/161:31 pm
ECP
- DSM
1 stop4h 23m
Delta
Deal found 4/7![Delta logo]()
$375
This Southwest deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/62:25 pm
DSM
- ECP
1 stop7h 10m
Southwest
Wed 8/1210:30 am
ECP
- DSM
2 stops11h 25m
Southwest
Deal found 4/5![Southwest logo]()
$376
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/44:48 pm
DSM
- ECP
1 stop5h 45m
American Airlines
Sat 7/116:48 pm
ECP
- DSM
1 stop5h 18m
American Airlines
Deal found 4/4![American Airlines logo]()
$407
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:41 pm
DSM
- ECP
1 stop4h 47m
Delta
Mon 5/116:00 am
ECP
- DSM
1 stop5h 08m
Delta
Deal found 4/7![Delta logo]()
$395
Last-minute flights from Des Moines to Panama CityDiscover last-minute flight deals from Des Moines to Panama City. Data last updated April 8, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Panama City. Data last updated April 8, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/26:40 am
DSM
- ECP
2 stops7h 50m
Southwest
Sat 5/99:55 am
ECP
- DSM
2 stops11h 00m
Southwest
Deal found 4/6![Southwest logo]()
$385
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/41:25 pm
DSM
- ECP
2 stops10h 21m
American Airlines
Tue 5/127:21 am
ECP
- DSM
1 stop5h 31m
American Airlines
Deal found 4/4![American Airlines logo]()
$360
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:25 am
DSM
- ECP
1 stop6h 10m
Southwest
Mon 5/115:00 pm
ECP
- DSM
1 stop6h 05m
Southwest
Deal found 4/6![Southwest logo]()
$375
This Delta deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:41 pm
DSM
- ECP
1 stop4h 47m
Delta
Mon 5/116:00 am
ECP
- DSM
1 stop5h 08m
Delta
Deal found 4/7![Delta logo]()
$395
This Delta deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:41 pm
DSM
- ECP
1 stop4h 47m
Delta
Tue 5/126:00 am
ECP
- DSM
1 stop5h 08m
Delta
Deal found 4/4![Delta logo]()
$371
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/86:00 am
DSM
- ECP
1 stop6h 36m
American Airlines
Tue 5/127:21 am
ECP
- DSM
2 stops9h 10m
American Airlines
Deal found 4/5![American Airlines logo]()
$376
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/164:00 pm
DSM
- ECP
1 stop6h 51m
Delta
Wed 5/209:19 am
ECP
- DSM
1 stop4h 18m
Delta
Deal found 4/5![Delta logo]()
$355
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/185:25 am
DSM
- ECP
1 stop6h 10m
Southwest
Fri 5/225:00 pm
ECP
- DSM
1 stop6h 05m
Southwest
Deal found 4/6![Southwest logo]()
$391
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/238:43 am
DSM
- ECP
2 stops9h 43m
American Airlines
Sat 5/303:48 pm
ECP
- DSM
1 stop6h 17m
American Airlines
Deal found 4/6![American Airlines logo]()
$380
One-way flights from Des Moines to Panama CitySearch for one-way flight options from Des Moines to Panama City. Find affordable one-way fares based on user searches. Data last updated April 8, 2026.
Search for one-way flight options from Des Moines to Panama City. Find affordable one-way fares based on user searches. Data last updated April 8, 2026.
This United Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/56:15 am
DSM
- ECP
1 stop6h 57m
United Airlines
Deal found 4/4![United Airlines logo]()
$168
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/512:00 pm
DSM
- ECP
2 stops10h 52m
American Airlines
Deal found 4/4![American Airlines logo]()
$173
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/86:39 pm
DSM
- ECP
1 stop5h 05m
Delta
Deal found 4/6![Delta logo]()
$188
This American Airlines deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/41:25 pm
DSM
- ECP
2 stops10h 21m
American Airlines
Deal found 4/4![American Airlines logo]()
$193
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:10 am
DSM
- ECP
2 stops9h 05m
Southwest
Deal found 4/6![Southwest logo]()
$199
This Delta deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/152:33 pm
DSM
- ECP
1 stop4h 36m
Delta
Deal found 4/6![Delta logo]()
$204
This Southwest deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/155:25 am
DSM
- ECP
2 stops10h 10m
Southwest
Deal found 4/6![Southwest logo]()
$215
This deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:15 am
DSM
- ECP
1 stop7h 03m
United Airlines
Deal found 4/7![United Airlines logo]()
$294
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:00 am
DSM
- ECP
2 stops10h 46m
American Airlines
Deal found 4/6![American Airlines logo]()
$305
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/37:14 am
DSM
- ECP
1 stop6h 09m
American Airlines
Deal found 4/7![American Airlines logo]()
$316
This Delta deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1011:33 am
DSM
- ECP
1 stop6h 25m
Delta
Deal found 4/3![Delta logo]()
$334
Find flight deals from Des Moines to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 8, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $335 (Delta) |
One-way from | $168 (United Airlines) |
Popular in | November |
Cheapest in | August |
Average price | $386 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 8, 2026.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Sat 5/16
4:00 pm-10:51 pm
1 stop6h 51m
Panama City NW Florida Beaches
Tue 5/19
1:50 pm-5:53 pm
1 stop4h 03m
$355
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Wed 7/1
6:02 am-12:45 pm
1 stop6h 43m
Panama City NW Florida Beaches
Wed 7/8
10:06 am-4:00 pm
1 stop5h 54m
$371
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Thu 8/6
6:38 pm-11:37 pm
1 stop4h 59m
Panama City NW Florida Beaches
Wed 8/12
7:45 am-1:22 pm
1 stop5h 37m
$371
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Mon 5/4
5:25 am-11:35 am
1 stop6h 10m
Panama City NW Florida Beaches
Mon 5/11
5:00 pm-11:05 pm
1 stop6h 05m
$375
Quickest round-trip
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Thu 6/4
2:33 pm-7:09 pm
1 stop4h 36m
Panama City NW Florida Beaches
Tue 6/16
1:31 pm-5:54 pm
1 stop4h 23m
$375
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Fri 6/19
5:10 am-10:50 am
1 stop5h 40m
Panama City NW Florida Beaches
Tue 6/23
7:00 am-3:05 pm
2 stops8h 05m
$376
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Fri 5/8
6:00 am-12:36 pm
1 stop6h 36m
Panama City NW Florida Beaches
Tue 5/12
11:43 am-11:16 pm
2 stops11h 33m
$376
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Thu 8/6
2:25 pm-9:35 pm
1 stop7h 10m
Panama City NW Florida Beaches
Wed 8/12
10:30 am-9:55 pm
2 stops11h 25m
$376
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Thu 5/7
6:41 pm-11:28 pm
1 stop4h 47m
Panama City NW Florida Beaches
Mon 5/11
6:00 am-11:08 am
1 stop5h 08m
$395
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Sat 7/4
4:48 pm-10:33 pm
1 stop5h 45m
Panama City NW Florida Beaches
Sat 7/11
6:48 pm-12:06 am
1 stop5h 18m
$407
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Panama City in April.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.
DSM-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Panama City
What is the cheapest month to book a flight from Des Moines to Panama City, Florida?
Currently, July is the cheapest month in which you can book a flight from Des Moines to Panama City, Florida (average of $108). Flying from Des Moines to Panama City, Florida in March is currently the most expensive (average of $337). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to Panama City, Florida?
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated April 8, 2026.
Read through reviews of airlines operating flights from Des Moines to Panama City, such as Southwest,Delta, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Entertainment
7.5
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Entertainment
7.5
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Entertainment
7.5
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Entertainment
7.5
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Comfort
8.0
Entertainment
7.5
Overall
8.0
Crew
8.6
Boarding
8.1
Food
7.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsMexico Beach
Browse thousands of different options on Cheapflights for your next trip
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Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
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Des Moines and Panama City flights
Browse other Des Moines and Panama City flight options. Last updated on April 8, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on April 8, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on April 8, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from Des Moines to Panama City
Discover the top 4 airlines that operate flights from Des Moines to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 8, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$239 | Average$428 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$283 | Average$364 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$297 | Average$394 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$342 | Average$503 | FlexibilityNo cancel fee | On-time69% |