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$119+ Cheap flights from Des Moines to Panama City, FL (DSM - ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — ECP
ago. 19 — ago. 261
mar. 8/19
mar. 8/26
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Panama City NW Florida Beaches are usually found in August or July, booked 69 days in advance, depart on a Tuesday or Monday and return on a Friday

Cheap flight deals from Des Moines to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated agosto 14, 2025.

Round-trip from

$209
(Delta)

One-way from

$119
(American Airlines)

Popular in

March

Cheapest in

August

Average price

$345
From Des Moines to Panama City NW Florida Beaches
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One-way flight from Des Moines to Panama City NW Florida Beaches
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Highest demand for flights based on searches. 11% potential increase in price ($59 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($24 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 14, 2025.

This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 10/76:39 pmDSM - ECP
1 stop4h 31mDelta
mar. 10/146:00 amECP - DSM
1 stop4h 05mDelta
Deal found 8/12$209
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/175:44 amDSM - ECP
1 stop4h 11mDelta
sáb. 9/206:00 amECP - DSM
1 stop4h 40mDelta
Deal found 8/14$223
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/136:10 amDSM - ECP
1 stop8h 05mSouthwest
sáb. 9/202:15 pmECP - DSM
1 stop6h 05mSouthwest
Deal found 8/14$237
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/132:49 pmDSM - ECP
2 stops8h 14mDelta
sáb. 9/206:00 amECP - DSM
1 stop4h 40mDelta
Deal found 8/14$242
This Delta deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/25:12 pmDSM - ECP
1 stop5h 54mDelta
vie. 9/55:02 pmECP - DSM
1 stop5h 41mDelta
Deal found 8/12$245
This American Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/26:28 amDSM - ECP
2 stops11h 07mAmerican Airlines
vie. 9/56:06 pmECP - DSM
1 stop5h 00mAmerican Airlines
Deal found 8/12$250
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/15:15 pmDSM - ECP
1 stop5h 55mDelta
vie. 11/76:00 amECP - DSM
1 stop4h 05mDelta
Deal found 8/14$259
This Southwest deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/118:20 amDSM - ECP
2 stops10h 45mSouthwest
vie. 11/143:20 pmECP - DSM
2 stops8h 15mSouthwest
Deal found 8/14$269

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 14, 2025.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Des Moines

Fly to

Panama City

Route

Depart

Return

Price

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

mar. 10/7

6:39 pm-11:10 pm

1 stop4h 31m

Panama City NW Florida Beaches

mar. 10/14

6:00 am-10:05 am

1 stop4h 05m

$209

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

mié. 10/8

6:39 pm-11:10 pm

1 stop4h 31m

Panama City NW Florida Beaches

mar. 10/14

6:00 am-10:05 am

1 stop4h 05m

$209

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

mié. 9/17

5:44 am-9:55 am

1 stop4h 11m

Panama City NW Florida Beaches

sáb. 9/20

6:00 am-10:40 am

1 stop4h 40m

$223

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

sáb. 9/13

6:10 am-2:15 pm

1 stop8h 05m

Panama City NW Florida Beaches

sáb. 9/20

2:15 pm-8:20 pm

1 stop6h 05m

$237

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

sáb. 9/13

4:09 pm-9:12 pm

1 stop5h 03m

Panama City NW Florida Beaches

sáb. 9/20

6:06 pm-11:06 pm

1 stop5h 00m

$237

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

sáb. 9/13

5:12 pm-11:03 pm

1 stop5h 51m

Panama City NW Florida Beaches

sáb. 9/20

6:00 am-10:40 am

1 stop4h 40m

$237

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

lun. 9/15

4:09 pm-9:12 pm

1 stop5h 03m

$119

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

dom. 9/28

5:11 am-11:06 am

1 stop5h 55m

$141

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

dom. 9/28

6:00 am-3:51 pm

2 stops9h 51m

$146

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

lun. 9/15

11:35 am-2:24 pm

3 stops26h 49m

$391

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/12

Showing 1-10 of 11 results
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Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama City

How far ahead should I book a flight from Des Moines to Panama City, Florida?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Panama City. Price data was last updated on August 8, 2025.

The best time to book flights from Des Moines to Panama City, Florida is 69 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Des Moines to Panama City, Florida?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Panama City, Florida (average of $346). Flying from Des Moines to Panama City, Florida in March is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated agosto 14, 2025.
Read through reviews of airlines operating flights from Des Moines to Panama City, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,244 reviews

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Overall

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,244 reviews
Southwest
8.0
Very good
4,244 reviews

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Overall

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
8.0
Very good
7,980 reviews
Southwest
8.0
Very good
4,244 reviews

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Overall

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
8,916 reviews
Southwest
8.0
Very good
4,244 reviews

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Overall

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,244 reviews

Boarding

8.1

Entertainment

7.5

Comfort

8.0

Overall

8.0

Crew

8.6

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Panama City, Florida round-trip?

    Cheapflights users have booked flights from Des Moines to Panama City, Florida round-trip from $256. Other airlines that can offer you cheap pricing are American Airlines, from $283, and United Airlines, from $302. Delta is priced at 41% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.

  • Can I find deals for business class flights from Des Moines to Panama City?

    Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama City, Florida?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Panama City, Florida (average of $346). Flying from Des Moines to Panama City, Florida in March is currently the most expensive (average of $460). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

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Top 4 airlines flying from Des Moines to Panama City

Discover the top 4 airlines that operate flights from Des Moines to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$256Average$406FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$283Average$367FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$302Average$477FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$351Average$426FlexibilityNo cancel feeOn-time63%

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