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$149+ Cheap flights from Des Moines to Panama City, FL (DSM - ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — ECP
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Panama City NW Florida Beaches are usually found in August or July, booked 69 days in advance, depart on a Tuesday or Monday and return on a Friday

Cheap flight deals from Des Moines to Panama City

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$297
(Delta)

One-way from

$149
(United Airlines)

Popular in

March

Cheapest in

August

Average price

$366
From Des Moines to Panama City NW Florida Beaches
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One-way flight from Des Moines to Panama City NW Florida Beaches
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Highest demand for flights based on searches. 13% potential increase in price ($70 potential increase over avg. RT price).
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Cheapest flight prices on average. 5% potential price decrease ($23 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/45:47 amDSM - ECP
1 stop4h 32mDelta
Tue 11/187:02 amECP - DSM
1 stop6h 30mDelta
Deal found 9/15$297
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/42:52 pmDSM - ECP
1 stop6h 57mUnited Airlines
Tue 11/186:30 amECP - DSM
2 stops9h 37mUnited Airlines
Deal found 9/15$302
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/206:22 pmDSM - ECP
1 stop5h 22mAmerican Airlines
Tue 10/283:38 pmECP - DSM
1 stop7h 38mAmerican Airlines
Deal found 9/15$305
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/46:15 amDSM - ECP
2 stops9h 35mSouthwest
Tue 11/1810:00 amECP - DSM
2 stops11h 35mSouthwest
Deal found 9/15$307
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/205:35 amDSM - ECP
1 stop4h 45mSouthwest
Tue 10/2811:00 amECP - DSM
2 stops9h 55mSouthwest
Deal found 9/15$310
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/36:39 pmDSM - ECP
1 stop4h 31mDelta
Mon 11/174:26 pmECP - DSM
1 stop6h 07mDelta
Deal found 9/15$313
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/255:15 pmDSM - ECP
1 stop5h 26mDelta
Fri 10/315:00 pmECP - DSM
1 stop5h 30mDelta
Deal found 9/17$315
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/2511:31 amDSM - ECP
2 stops10h 17mUnited Airlines
Fri 10/315:00 pmECP - DSM
1 stop5h 20mUnited Airlines
Deal found 9/16$320
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/153:05 pmDSM - ECP
1 stop6h 43mUnited Airlines
Wed 10/221:55 pmECP - DSM
1 stop7h 55mUnited Airlines
Deal found 9/15$340

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Des Moines

Fly to

Panama City

Route

Depart

Return

Price

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 11/4

5:47 am-10:19 am

1 stop4h 32m

Panama City NW Florida Beaches

Tue 11/18

7:02 am-1:32 pm

1 stop6h 30m

$297

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 11/4

2:52 pm-9:49 pm

1 stop6h 57m

Panama City NW Florida Beaches

Tue 11/18

6:30 am-4:07 pm

2 stops9h 37m

$302

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Mon 10/20

6:22 pm-11:44 pm

1 stop5h 22m

Panama City NW Florida Beaches

Tue 10/28

3:38 pm-11:16 pm

1 stop7h 38m

$305

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Mon 10/27

5:47 am-12:30 pm

1 stop6h 43m

Panama City NW Florida Beaches

Wed 10/29

6:00 am-10:05 am

1 stop4h 05m

$305

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Tue 11/4

6:15 am-3:50 pm

2 stops9h 35m

Panama City NW Florida Beaches

Tue 11/18

10:00 am-9:35 pm

2 stops11h 35m

$307

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Mon 11/3

6:39 pm-11:10 pm

1 stop4h 31m

Panama City NW Florida Beaches

Mon 11/17

4:26 pm-10:33 pm

1 stop6h 07m

$313

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Mon 10/27

1:48 pm-11:44 pm

2 stops9h 56m

Panama City NW Florida Beaches

Wed 10/29

11:58 am-10:03 pm

2 stops10h 05m

$315

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Sat 10/25

5:15 pm-10:41 pm

1 stop5h 26m

Panama City NW Florida Beaches

Fri 10/31

5:00 pm-10:30 pm

1 stop5h 30m

$315

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Sat 10/25

11:31 am-9:48 pm

2 stops10h 17m

Panama City NW Florida Beaches

Fri 10/31

5:00 pm-10:20 pm

1 stop5h 20m

$320

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

Wed 10/15

5:42 pm-10:53 pm

1 stop5h 11m

Panama City NW Florida Beaches

Wed 10/22

11:58 am-5:02 pm

1 stop5h 04m

$340

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 16 results
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Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama City

How far ahead should I book a flight from Des Moines to Panama City, Florida?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Panama City. Price data was last updated on September 12, 2025.

The best time to book flights from Des Moines to Panama City, Florida is 69 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Des Moines to Panama City, Florida?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Panama City, Florida (average of $346). Flying from Des Moines to Panama City, Florida in March is currently the most expensive (average of $459). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Panama City

Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 17, 2025.
Read through reviews of airlines operating flights from Des Moines to Panama City, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
Delta
8.0
Very good
7,961 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
United Airlines
7.4
Good
8,926 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Comfort

8.0

Boarding

8.1

Food

7.0

Crew

8.6

Entertainment

7.5

Overall

8.0

Reviews

1 / 20
2.0
Mediocre

Mike,Aug 2025

OKC - AUS

AC was not adequate, even on a night flight. WiFi subpar even for the airlines

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Panama City, Florida?

    Airlines like Delta, United Airlines, and American Airlines fly from Des Moines to Panama City, Florida in about 4h 32m. The time it takes to get you to your destination can typically vary by up to 2h 25m. There are 887 mi between Des Moines and Panama City, Florida. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Des Moines to Panama City, Florida round-trip?

    Cheapflights users have booked flights from Des Moines to Panama City, Florida round-trip from $239. Other airlines that can offer you cheap pricing are American Airlines, from $283, and United Airlines, from $302. Delta is priced at 47% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Panama City, Florida one-way?

    One-way options have recently been found by users for as low as $149 on United Airlines. Other airlines that offer cheap prices include American Airlines from $157 and Delta from $157 one-way.

  • Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

    Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.

  • Can I find deals for business class flights from Des Moines to Panama City?

    Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Panama City, Florida?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Panama City, Florida (average of $346). Flying from Des Moines to Panama City, Florida in March is currently the most expensive (average of $459). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Mexico Beach

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Top 4 airlines flying from Des Moines to Panama City

Discover the top 4 airlines that operate flights from Des Moines to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$239Average$432FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$283Average$373FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$302Average$586FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$302Average$409FlexibilityNo cancel feeOn-time63%

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