What are the cheapest airlines flying from Des Moines to Panama City, Florida round-trip?

Cheapflights users have booked flights from Des Moines to Panama City, Florida round-trip from $271. Other airlines that can offer you cheap pricing are American Airlines, from $299, and Southwest, from $332. Delta is priced at 37% lower than the current average price of a flight leaving 3 months from now.

What are the cheapest airlines to fly from Des Moines to Panama City, Florida one-way?

One-way options have recently been found by users for as low as $136 on Delta. Other airlines that offer cheap prices include American Airlines from $184 and United Airlines from $394 one-way.

What is the cheapest day to fly from Des Moines to Panama City, Florida?

Travelers seeking maximum savings on their Des Moines to Panama City, Florida flight should consider departing on Tuesday afternoons when fares are most often at their lowest. Friday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

What are the most popular airlines that fly from Des Moines to Panama City, Florida?

Before booking your flight from Des Moines to Panama City, Florida check out the most popular airlines for this route: American Airlines, Delta or United Airlines.

What is the cheapest day to fly round-trip from Des Moines to Panama City, Florida?

Travelers have found that booking a Monday departure is the best way to save up to 30% on the cost of booking your flights compared to booking on days of the week where this route is of high demand.

How far in advance should I book a flight from Des Moines to Panama City, Florida?

Find a great deal and save up to 56% by booking at least 32 days prior to your desired departure date, rather than waiting until the week of travel. According to our data, there are a number of flights available from Des Moines to Panama City, Florida within the next two weeks, with the cheapest ticket starting at $443.

What is the cheapest month to fly from Des Moines to Panama City, Florida?

Our data shows that September tends to be the cheapest month to fly to Panama City, Florida from Des Moines. Users have commonly found prices around $436 for the month, but tickets can be as low as $272. Due to multiple factors, prepare for potentially higher prices in March.

Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Panama City?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.

Can I find deals for business class flights from Des Moines to Panama City?

Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$136+ Flights from Des Moines to Panama City, FL

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Cheapflights Tip: The best prices from Des Moines to Panama City NW Florida Beaches are usually found in September or August, booked 69 days in advance, depart on a Tuesday or Monday and return on a Friday

Cheap flight deals from Des Moines to Panama City

Round-trip from	$271 (Delta)
One-way from	$136 (Delta)
Popular in	March
Cheapest in	September
Average price	$392

From Des Moines to Panama City NW Florida Beaches

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One-way flight from Des Moines to Panama City NW Florida Beaches

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Highest demand for flights based on searches. 12% potential increase in price ($60 potential increase over avg. RT price).

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Cheapest flight prices on average. 4% potential price decrease ($20 potential savings vs. average RT price).

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Average for round-trip flights in June 2025

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Find flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

jue. 11/272:14 pmDSM - ECP

1 stop5h 24mDelta

mié. 12/36:00 amECP - DSM

1 stop4h 18mDelta

Deal found 6/11

$271

sáb. 11/155:45 amDSM - ECP

2 stops10h 18mUnited Airlines

mié. 11/196:30 amECP - DSM

1 stop7h 41mUnited Airlines

Deal found 6/12

$294

sáb. 11/155:56 amDSM - ECP

2 stops7h 55mAmerican Airlines

mié. 11/1911:16 amECP - DSM

2 stops8h 56mAmerican Airlines

Deal found 6/12

$299

jue. 7/105:25 amDSM - ECP

1 stop3h 50mSouthwest

mar. 7/156:05 amECP - DSM

1 stop4h 55mSouthwest

Deal found 6/10

$332

Best flights from Des Moines to Panama City
Discover carefully curated flight deals from Des Moines to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated junio 12, 2025.

jue. 11/272:14 pmDSM - ECP

1 stop5h 24mDelta

mié. 12/36:00 amECP - DSM

1 stop4h 18mDelta

Deal found 6/11

$271

sáb. 11/155:56 amDSM - ECP

2 stops7h 55mAmerican Airlines

mié. 11/1911:16 amECP - DSM

2 stops8h 56mAmerican Airlines

Deal found 6/12

$299

jue. 7/105:25 amDSM - ECP

1 stop3h 50mSouthwest

mar. 7/156:05 amECP - DSM

1 stop4h 55mSouthwest

Deal found 6/10

$332

mié. 8/136:24 amDSM - ECP

2 stops9h 57mUnited Airlines

dom. 8/1711:10 amECP - DSM

2 stops23h 19mUnited Airlines

Deal found 6/11

$446

Last-minute flights from Des Moines to Panama City
Discover last-minute flight deals from Des Moines to Panama City. Data last updated junio 12, 2025 and is based on user searches.

mar. 6/175:35 pmDSM - ECP

1 stop4h 00mSouthwest

mar. 6/246:05 amECP - DSM

1 stop4h 55mSouthwest

Deal found 6/10

$563

sáb. 7/58:00 amDSM - ECP

2 stops10h 59mUnited Airlines

mar. 7/83:04 pmECP - DSM

2 stops8h 55mUnited Airlines

Deal found 6/12

$467

jue. 7/105:25 amDSM - ECP

1 stop3h 50mSouthwest

mar. 7/156:05 amECP - DSM

1 stop4h 55mSouthwest

Deal found 6/10

$332

jue. 7/105:00 amDSM - ECP

2 stops9h 05mAmerican Airlines

mar. 7/152:35 pmECP - DSM

2 stops7h 31mAmerican Airlines

Deal found 6/10

$352

mié. 7/162:29 pmDSM - ECP

1 stop7h 04mDelta

mié. 7/234:52 pmECP - DSM

1 stop5h 41mDelta

Deal found 6/11

$297

One-way flights from Des Moines to Panama City
Search for one-way flight options from Des Moines to Panama City. Find affordable one-way fares based on user searches. Data last updated junio 12, 2025.

jue. 9/45:12 pmDSM - ECP

1 stop5h 54mDelta

Deal found 6/10

$136

vie. 7/255:17 pmDSM - ECP

1 stop6h 36mAmerican Airlines

Deal found 6/10

$184

sáb. 10/118:15 amDSM - ECP

3 stops25h 36mUnited Airlines

Deal found 6/11

$394

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

jue. 11/27

2:14 pm-7:38 pm

1 stop5h 24m

Panama City NW Florida Beaches

mié. 12/3

6:00 am-10:18 am

1 stop4h 18m

$271

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

sáb. 11/15

5:45 am-4:03 pm

2 stops10h 18m

Panama City NW Florida Beaches

mié. 11/19

6:30 am-2:11 pm

1 stop7h 41m

$294

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

sáb. 11/15

5:56 am-1:51 pm

2 stops7h 55m

Panama City NW Florida Beaches

mié. 11/19

11:16 am-8:12 pm

2 stops8h 56m

$299

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

jue. 7/10

5:25 am-9:15 am

1 stop3h 50m

Panama City NW Florida Beaches

mar. 7/15

6:05 am-11:00 am

1 stop4h 55m

$332

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

jue. 9/4

5:12 pm-11:06 pm

1 stop5h 54m

$136

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

vie. 7/25

5:17 pm-11:53 pm

1 stop6h 36m

$184

Des MoinesPanama City

DSM - ECP

DSMECP

Des Moines

sáb. 10/11

8:15 am-9:51 am

3 stops25h 36m

$394

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama City

How far ahead should I book a flight from Des Moines to Panama City, Florida?

The best time to book flights from Des Moines to Panama City, Florida is 69 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Des Moines to Panama City, Florida?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Panama City, Florida (average of $346). Flying from Des Moines to Panama City, Florida in March is currently the most expensive (average of $461). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to ECP?

One of the essential ways to save on airfare from Des Moines to Panama City, Florida is to remain as flexible as possible. Flights that are in the morning tend to be the most expensive. A flight in the afternoon could potentially save you up to 6% on airfare.

Rainfall in Panama City by month

In terms of precipitation, rainfall in Panama City, Florida ranges from 2.8 - 7.9 inches per month. July is typically the wettest month, when rainfall can reach 7.9 in. May is typically the driest time to visit Panama City, Florida when rainfall is around 2.8 in.

Temperature in Panama City by month

If weather is an important factor for your trip to Panama City, Florida, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 53.6 F).

Reviews of airlines servicing Panama City

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Southwest

8.0

Very good

4,287 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Delta

8.0

Very good

7,950 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

United Airlines

7.4

Good

8,790 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,287 reviews

Reviews

1 / 20

8.0

Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

What are the cheapest airlines flying from Des Moines to Panama City, Florida round-trip?
Cheapflights users have booked flights from Des Moines to Panama City, Florida round-trip from $271. Other airlines that can offer you cheap pricing are American Airlines, from $299, and Southwest, from $332. Delta is priced at 37% lower than the current average price of a flight leaving 3 months from now.
What are the cheapest airlines to fly from Des Moines to Panama City, Florida one-way?
One-way options have recently been found by users for as low as $136 on Delta. Other airlines that offer cheap prices include American Airlines from $184 and United Airlines from $394 one-way.
Can I find deals for flights from Des Moines to Panama City that include hotel bookings?
Yes. In addition to deals on Des Moines to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Panama City?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Panama City.
Can I find deals for business class flights from Des Moines to Panama City?
Yes. Cheapflights offers flight deals from Des Moines to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Panama City, Florida?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Panama City, Florida (average of $346). Flying from Des Moines to Panama City, Florida in March is currently the most expensive (average of $461). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Mexico Beach

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Top 4 airlines flying from Des Moines to Panama City

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$283	Average$414	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$286	Average$421	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$302	Average$477	FlexibilityNo cancel fee	On-time69%
Southwest	Cheapest$351	Average$426	FlexibilityNo cancel fee	On-time63%

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$136+ Cheap flights from Des Moines to Panama City, FL (DSM - ECP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/4. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Panama City with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Des Moines to Panama City NW Florida Beaches are usually found in September or August, booked 69 days in advance, depart on a Tuesday or Monday and return on a Friday

Cheap flight deals from Des Moines to Panama City

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Find flight deals from Des Moines to Panama City

Cheapest flights from Des Moines to Panama CityExplore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.

Best time to book a flight from Des Moines to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Panama City

How far ahead should I book a flight from Des Moines to Panama City, Florida?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Panama City. Price data was last updated on June 9, 2025.

What is the cheapest month to book a flight from Des Moines to Panama City, Florida?

What is the cheapest time of day to fly from DSM to ECP?

Find hourly flight availability from Des Moines to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated junio 12, 2025.

Rainfall in Panama City by month

Plan your trip to Panama City by taking into account the average rainfall totals by month.

Temperature in Panama City by month

Plan your trip to Panama City by taking into account the average temperature totals by month.

Reviews of airlines servicing Panama City

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What are the cheapest airlines flying from Des Moines to Panama City, Florida round-trip?

What are the cheapest airlines to fly from Des Moines to Panama City, Florida one-way?

Can I find deals for flights from Des Moines to Panama City that include hotel bookings?

How can I find direct flights from Des Moines to Panama City?

Can I find deals for business class flights from Des Moines to Panama City?

What is the cheapest month to book a flight from Des Moines to Panama City, Florida?

Traveling to a place near Des Moines?

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Alternative routes for Des Moines to Panama City

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Des Moines to Panama City

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Cheapest flights from Des Moines to Panama City
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on junio 12, 2025.