$143+ Cheap flights from Des Moines to Panama City, FL (DSM - ECP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/18. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — ECP
Feb 6 — Feb 131
1 adult, Economy
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Find cheap flights from Des Moines to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 7, 2026.
Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $290 (American Airlines) |
One-way from | $143 (Delta) |
Popular in | March |
Cheapest in | August |
Average price | $368 |
Find flight deals from Des Moines to Panama City
Cheapest flights from Des Moines to Panama CityExplore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 7, 2026.
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 7, 2026.
This American Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/47:10 amDSM - ECP
2 stops10h 23mAmerican Airlines
Wed 2/116:03 pmECP - DSM
1 stop5h 05mAmerican Airlines
Deal found 1/5![American Airlines logo]()
$290
This Southwest deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/46:10 amDSM - ECP
2 stops8h 45mSouthwest
Wed 2/1110:30 amECP - DSM
2 stops10h 40mSouthwest
Deal found 1/5![Southwest logo]()
$296
This Delta deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/275:16 pmDSM - ECP
1 stop5h 24mDelta
Mon 2/26:09 pmECP - DSM
1 stop4h 20mDelta
Deal found 1/6![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 1/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/16:40 amDSM - ECP
2 stops10h 50mSouthwest
Mon 4/64:30 pmECP - DSM
1 stop5h 50mSouthwest
Deal found 1/4![Southwest logo]()
$325
This American Airlines deal was found by Cheapflights users on 1/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/237:44 pmDSM - ECP
1 stop18h 40mAmerican Airlines
Mon 3/23:00 pmECP - DSM
1 stop18h 01mAmerican Airlines
Deal found 1/5![American Airlines logo]()
$328
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:44 pmDSM - ECP
1 stop17h 00mAmerican Airlines
Thu 3/51:18 pmECP - DSM
1 stop8h 33mAmerican Airlines
Deal found 1/6![American Airlines logo]()
$335
This American Airlines deal was found by Cheapflights users on 1/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/145:00 amDSM - ECP
1 stop9h 24mAmerican Airlines
Tue 2/171:19 pmECP - DSM
1 stop9h 00mAmerican Airlines
Deal found 1/7![American Airlines logo]()
$336
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/21:48 pmDSM - ECP
2 stops10h 01mAmerican Airlines
Mon 3/93:00 pmECP - DSM
1 stop18h 01mAmerican Airlines
Deal found 1/6![American Airlines logo]()
$342
This American Airlines deal was found by Cheapflights users on 1/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/205:00 amDSM - ECP
2 stops11h 04mAmerican Airlines
Wed 2/252:00 pmECP - DSM
2 stops8h 19mAmerican Airlines
Deal found 1/6![American Airlines logo]()
$347
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 7, 2026.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.
Fly from
Des Moines
Fly to
Panama City
Route
Depart
Return
Price
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Wed 2/4
6:10 am-2:55 pm
2 stops8h 45m
Panama City NW Florida Beaches
Wed 2/11
10:30 am-9:10 pm
2 stops10h 40m
$296
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Thu 2/12
6:32 am-2:24 pm
1 stop7h 52m
Panama City NW Florida Beaches
Tue 2/17
1:19 pm-11:40 pm
1 stop10h 21m
$319
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Mon 3/2
7:44 pm-12:44 pm
1 stop17h 00m
Panama City NW Florida Beaches
Mon 3/9
3:00 pm-9:01 am
1 stop18h 01m
$319
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Tue 1/27
4:21 pm-10:40 pm
2 stops6h 19m
Panama City NW Florida Beaches
Mon 2/2
12:59 pm-7:34 pm
1 stop6h 35m
$324
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Wed 4/1
6:40 am-5:30 pm
2 stops10h 50m
Panama City NW Florida Beaches
Mon 4/6
4:30 pm-10:20 pm
1 stop5h 50m
$325
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Mon 2/23
7:44 pm-2:24 pm
1 stop18h 40m
Panama City NW Florida Beaches
Mon 3/2
3:00 pm-9:01 am
1 stop18h 01m
$328
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Sat 4/4
3:04 pm-9:59 pm
1 stop6h 55m
Panama City NW Florida Beaches
Tue 4/7
4:57 pm-10:43 pm
1 stop5h 46m
$336
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Sat 2/14
5:00 am-2:24 pm
1 stop9h 24m
Panama City NW Florida Beaches
Tue 2/17
1:19 pm-10:19 pm
1 stop9h 00m
$336
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Fri 4/3
1:10 pm-9:59 pm
2 stops8h 49m
Panama City NW Florida Beaches
Tue 4/7
4:57 pm-10:43 pm
1 stop5h 46m
$341
Des MoinesPanama City
DSM - ECP
DSMECP
Des Moines
Wed 2/18
5:15 pm-10:39 pm
1 stop5h 24m
$143
Showing 1-10 of 18 results
Compare providers for flights from Des Moines to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Panama City in January.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy2 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*1 star | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Panama City, Florida flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Panama City, Florida flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Panama City, Florida flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Panama City
How far ahead should I book a flight from Des Moines to Panama City, Florida?
Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Panama City. Price data was last updated on January 2, 2026.
The best time to book flights from Des Moines to Panama City, Florida is 70 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Des Moines to Panama City, Florida?
Currently, July is the cheapest month in which you can book a flight from Des Moines to Panama City, Florida (average of $108). Flying from Des Moines to Panama City, Florida in February is currently the most expensive (average of $277). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated January 7, 2026.
Read through reviews of airlines operating flights from Des Moines to Panama City, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Overall
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Overall
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Overall
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Overall
8.0
Boarding
8.1
Entertainment
7.5
Crew
8.6
Comfort
8.0
Food
7.0
Reviews
1 / 20
2.0
MediocreThomas,Dec 2025
SEA - DEN
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsMexico Beach
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Alternative routes for Des Moines to Panama City
See prices for flight routes from nearby airports that may be better suited for you.
Top 4 airlines flying from Des Moines to Panama City
Discover the top 4 airlines that operate flights from Des Moines to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$239 | Average$426 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$283 | Average$373 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$296 | Average$586 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$302 | Average$396 | FlexibilityNo cancel fee | On-time63% |