$339+ Cheap flights from Des Moines to Panama City, FL (DSM - ECP)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/31. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — ECP
Oct 30 — Nov 61
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Panama City
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Cheapest flights from Des Moines to Panama CityExplore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 30, 2026.
Explore the most affordable flight options available from Des Moines to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 30, 2026.
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/38:00 am -
1 stop6h 28m
Tue 11/174:55 pm -
1 stop5h 35m
Deal found 9/29![United Airlines logo]()
$339
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/43:31 pm -
1 stop5h 24m
Tue 12/83:56 pm -
1 stop7h 34m
Deal found 9/29![American Airlines logo]()
$357
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/48:00 am -
1 stop5h 17m
Tue 12/81:30 pm -
2 stops9h 45m
Deal found 9/29![United Airlines logo]()
$362
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:54 pm -
1 stop4h 24m
Fri 11/66:00 am -
1 stop4h 42m
Deal found 9/30![Delta logo]()
$395
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:00 am -
2 stops9h 10m
Tue 12/810:05 am -
2 stops10h 40m
Deal found 9/29![Southwest logo]()
$398
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:22 am -
1 stop7h 20m
Fri 11/67:01 pm -
1 stop4h 56m
Deal found 9/30![American Airlines logo]()
$406
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:52 pm -
1 stop4h 32m
Thu 11/265:16 pm -
1 stop5h 19m
Deal found 9/26![Delta logo]()
$407
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:00 am -
1 stop5h 06m
Thu 10/299:06 am -
2 stops12h 49m
Deal found 9/27![United Airlines logo]()
$416
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:22 am -
1 stop7h 20m
Mon 11/1612:00 pm -
2 stops9h 20m
Deal found 9/29![American Airlines logo]()
$421
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:01 pm -
1 stop6h 35m
Fri 11/69:06 am -
2 stops12h 49m
Deal found 9/30![United Airlines logo]()
$436
Best flights from Des Moines to Panama CityDiscover carefully curated flight deals from Des Moines to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 30, 2026.
Discover carefully curated flight deals from Des Moines to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 30, 2026.
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/38:00 am -
1 stop6h 28m
Tue 11/179:06 am -
2 stops11h 30m
Deal found 9/29![United Airlines logo]()
$344
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:54 pm -
1 stop4h 24m
Fri 11/66:00 am -
1 stop4h 42m
Deal found 9/30![Delta logo]()
$395
This Southwest deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:00 am -
2 stops9h 10m
Tue 12/810:05 am -
2 stops10h 40m
Deal found 9/29![Southwest logo]()
$398
This United Airlines deal was found by Cheapflights users on 9/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/69:37 am -
2 stops12h 06m
Wed 3/34:55 pm -
1 stop5h 38m
Deal found 9/25![United Airlines logo]()
$344
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/318:00 am -
2 stops8h 18m
Sat 11/149:06 am -
2 stops11h 30m
Deal found 9/29![United Airlines logo]()
$349
This Delta deal was found by Cheapflights users on 9/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/206:52 pm -
1 stop4h 32m
Thu 11/265:16 pm -
1 stop5h 19m
Deal found 9/26![Delta logo]()
$407
This Southwest deal was found by Cheapflights users on 9/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/246:55 am -
2 stops8h 20m
Tue 3/27:55 am -
2 stops13h 40m
Deal found 9/28![Southwest logo]()
$432
This Southwest deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/116:45 am -
2 stops10h 45m
Sat 2/2010:40 am -
2 stops11h 40m
Deal found 9/27![Southwest logo]()
$442
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/308:00 am -
1 stop6h 20m
Wed 2/32:08 pm -
1 stop6h 02m
Deal found 9/27![United Airlines logo]()
$439
Last-minute flights from Des Moines to Panama CityDiscover last-minute flight deals from Des Moines to Panama City. Data last updated September 30, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Panama City. Data last updated September 30, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 9/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/226:00 am -
1 stop5h 06m
Thu 10/299:06 am -
2 stops12h 49m
Deal found 9/27![United Airlines logo]()
$416
This Delta deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:54 pm -
1 stop4h 24m
Fri 11/66:00 am -
1 stop4h 42m
Deal found 9/30![Delta logo]()
$395
This American Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/3011:22 am -
1 stop7h 20m
Fri 11/67:01 pm -
1 stop4h 56m
Deal found 9/30![American Airlines logo]()
$406
This United Airlines deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:01 pm -
1 stop6h 35m
Fri 11/69:06 am -
2 stops12h 49m
Deal found 9/30![United Airlines logo]()
$436
This Southwest deal was found by Cheapflights users on 9/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:10 am -
2 stops8h 00m
Fri 11/611:25 am -
2 stops10h 40m
Deal found 9/30![Southwest logo]()
$467
This American Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/3111:22 am -
1 stop7h 20m
Mon 11/165:41 pm -
1 stop5h 45m
Deal found 9/29![American Airlines logo]()
$339
This United Airlines deal was found by Cheapflights users on 9/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/311:27 pm -
2 stops8h 09m
Sat 11/141:50 pm -
1 stop5h 26m
Deal found 9/29![United Airlines logo]()
$344
Find flight deals from Des Moines to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Panama City (ECP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 30, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $339 (United Airlines) |
Popular in | December |
Cheapest in | September |
Average price | $324 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 30, 2026.
Use the filters below to find and compare flights from Des Moines to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesPanama City
DSM Des Moines - ECP Panama City NW Florida Beaches
DSMECP
Des Moines
Tue 11/3
8:00 am-2:28 pm
1 stop6h 28m
Panama City NW Florida Beaches
Tue 11/17
9:06 am-8:36 pm
2 stops11h 30m
$344
Des MoinesPanama City
DSM Des Moines - ECP Panama City NW Florida Beaches
DSMECP
Des Moines
Wed 1/6
9:37 am-9:43 pm
2 stops12h 06m
Panama City NW Florida Beaches
Wed 3/3
4:55 pm-10:33 pm
1 stop5h 38m
$344
Des MoinesPanama City
DSM Des Moines - ECP Panama City NW Florida Beaches
DSMECP
Des Moines
Sat 10/31
8:00 am-4:18 pm
2 stops8h 18m
Panama City NW Florida Beaches
Sat 11/14
9:06 am-8:36 pm
2 stops11h 30m
$349
Quickest round-trip
Des MoinesPanama City
DSM Des Moines - ECP Panama City NW Florida Beaches
DSMECP
Des Moines
Fri 10/30
6:54 pm-11:18 pm
1 stop4h 24m
Panama City NW Florida Beaches
Fri 11/6
6:00 am-10:42 am
1 stop4h 42m
$395
Des MoinesPanama City
DSM Des Moines - ECP Panama City NW Florida Beaches
DSMECP
Des Moines
Fri 12/4
6:00 am-3:10 pm
2 stops9h 10m
Panama City NW Florida Beaches
Tue 12/8
10:05 am-8:45 pm
2 stops10h 40m
$398
Des MoinesPanama City
DSM Des Moines - ECP Panama City NW Florida Beaches
DSMECP
Des Moines
Fri 11/20
6:52 pm-11:24 pm
1 stop4h 32m
Panama City NW Florida Beaches
Thu 11/26
5:16 pm-10:35 pm
1 stop5h 19m
$407
Des MoinesPanama City
DSM Des Moines - ECP Panama City NW Florida Beaches
DSMECP
Des Moines
Wed 2/24
6:55 am-3:15 pm
2 stops8h 20m
Panama City NW Florida Beaches
Tue 3/2
7:55 am-9:35 pm
2 stops13h 40m
$432
Des MoinesPanama City
DSM Des Moines - ECP Panama City NW Florida Beaches
DSMECP
Des Moines
Sat 1/30
8:00 am-2:20 pm
1 stop6h 20m
Panama City NW Florida Beaches
Wed 2/3
2:08 pm-8:10 pm
1 stop6h 02m
$439
Des MoinesPanama City
DSM Des Moines - ECP Panama City NW Florida Beaches
DSMECP
Des Moines
Thu 2/11
6:45 am-5:30 pm
2 stops10h 45m
Panama City NW Florida Beaches
Sat 2/20
10:40 am-10:20 pm
2 stops11h 40m
$442
Sorted by cheapest first
Compare providers for flights from Des Moines to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Panama City in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Panama City, Florida flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Panama City, Florida flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Panama City, Florida flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Panama City, Florida flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Panama City, Florida flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Des Moines with our price prediction graph.
DSM-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Panama City
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated September 30, 2026.
Read through reviews of airlines operating flights from Des Moines to Panama City, such as Southwest,Delta, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Food
7.0
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Food
7.0
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Food
7.0
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Food
7.0
Entertainment
7.5
Comfort
8.0
Overall
8.0
Crew
8.6
Boarding
8.1
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Des Moines to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Panama City flights
Browse other Des Moines and Panama City flight options. Last updated on September 30, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on September 30, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on September 30, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from Des Moines to Panama City
Discover the top 4 airlines that operate flights from Des Moines to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 30, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$271 | Average$468 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$285 | Average$386 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$342 | Average$503 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$374 | Average$406 | FlexibilityNo cancel fee | On-time63% |