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North Carolina

$70+ Cheap flights from Des Moines (DSM) to North Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/27. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — RDU
Feb 26 — Mar 51
Thu 2/26
Thu 3/5
1 adult, Economy
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Cheap flight deals from Des Moines to North Carolina

Cheapest flights from Des Moines to North Carolina
Explore the most affordable flight options available from Des Moines to North Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 27, 2026.

This CheapOair deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:27 pm
DSM
-
CLT
1 stop19h 51m
Frontier
Thu 3/55:13 pm
CLT
-
DSM
1 stop27h 03m
Frontier
Deal found 1/27$184
This American Airlines deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:00 am
DSM
-
CLT
1 stop10h 04m
American Airlines
Mon 4/138:46 pm
CLT
-
DSM
Nonstop2h 32m
American Airlines
Deal found 1/25$211
This CheapOair deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:27 pm
DSM
-
CLT
1 stop22h 21m
Frontier
Thu 3/127:43 pm
CLT
-
DSM
1 stop24h 33m
Frontier
Deal found 1/25$219
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/267:27 pm
DSM
-
CLT
2 stops21h 58m
Multiple Airlines
Thu 3/511:00 am
CLT
-
DSM
1 stop12h 51m
Multiple Airlines
Deal found 1/27$246
This CheapOair deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:27 pm
DSM
-
CLT
1 stop22h 21m
Frontier
Sun 3/87:43 pm
CLT
-
DSM
1 stop24h 33m
Frontier
Deal found 1/27$259
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/107:00 am
DSM
-
MYR
1 stop10h 56m
Multiple Airlines
Wed 5/137:51 pm
MYR
-
DSM
1 stop20h 24m
Multiple Airlines
Deal found 1/25$260
This CheapOair deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:20 pm
DSM
-
CLT
1 stop25h 32m
Frontier
Sun 4/197:49 pm
CLT
-
DSM
1 stop18h 40m
Frontier
Deal found 1/25$261
This Kiwi.com deal was found by Cheapflights users on 1/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/57:27 pm
DSM
-
CLT
1 stop22h 21m
Multiple Airlines
Thu 3/129:18 am
CLT
-
DSM
2 stops11h 56m
Multiple Airlines
Deal found 1/25$262
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/168:21 pm
DSM
-
RDU
1 stop20h 27m
Multiple Airlines
Wed 3/257:46 pm
RDU
-
DSM
1 stop18h 43m
Multiple Airlines
Deal found 1/26$264
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/235:25 pm
DSM
-
GSO
1 stop4h 31m
Delta
Tue 6/305:25 am
GSO
-
DSM
1 stop5h 49m
Delta
Deal found 1/26$269
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/75:24 am
DSM
-
AVL
1 stop4h 40m
Delta
Sun 3/155:40 am
AVL
-
DSM
1 stop6h 08m
Delta
Deal found 1/27$269
This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/84:30 pm
DSM
-
CLT
2 stops31h 10m
Multiple Airlines
Wed 2/117:43 pm
CLT
-
DSM
1 stop28h 29m
Multiple Airlines
Deal found 1/26$270

Find flight deals from Des Moines to North Carolina

Keep the following information in mind while searching for Des Moines to North Carolina flight deals. Data was last updated January 27, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

Expedia
3 stars

Round-trip from

$211
(American Airlines)

One-way from

$70
(Trip.com)

Popular in

January

Cheapest in

September

Average price

$549

Good round-trip deal

$381 or less

Good one-way deal

$233 or less
Provider with most accurate pricing for Des Moines-Raleigh-Durham flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Raleigh-Durham flights.
Search Deals
From Des Moines to North Carolina
Search Deals
One-way flight from Des Moines to North Carolina
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($74 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($16 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals
Price to beat on a round-trip flight from Des Moines to North Carolina.
Search Deals
Price to beat on a one-way flight from Des Moines to North Carolina.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to North Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
Use the filters below to find and compare flights from Des Moines to North Carolina that are best for you.

Fly from

Des Moines

Fly to

North Carolina

Route

Depart

Return

Price

Des MoinesGreensboro

DSM - GSO

DSMGSO

Des Moines

Fri 2/20

3:24 pm-8:42 pm

1 stop4h 18m

Greensboro/H. Point

Mon 2/23

5:19 pm-9:41 pm

1 stop5h 22m

$269

Des MoinesAsheville

DSM - AVL

DSMAVL

Des Moines

Sat 3/7

5:24 am-11:04 am

1 stop4h 40m

Asheville Regional

Sun 3/15

5:40 am-10:48 am

1 stop6h 08m

$269

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 3/10

5:20 pm-11:57 pm

1 stop5h 37m

Knoxville McGhee Tyson

Sat 3/14

5:40 am-10:48 am

1 stop6h 08m

$271

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Wed 4/1

3:21 pm-11:03 pm

1 stop6h 42m

Knoxville McGhee Tyson

Wed 4/8

7:00 am-12:29 pm

1 stop6h 29m

$271

Des MoinesAsheville

DSM - AVL

DSMAVL

Des Moines

Tue 2/24

7:15 am-2:55 pm

1 stop6h 40m

Asheville Regional

Sat 2/28

4:17 pm-11:40 pm

2 stops8h 23m

$274

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Thu 3/5

7:27 pm-5:48 pm

1 stop21h 21m

Raleigh-Durham

Tue 3/10

4:12 pm-7:16 pm

2 stops28h 04m

$280

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Mon 4/20

3:04 pm-11:41 pm

1 stop7h 37m

Knoxville McGhee Tyson

Sat 4/25

7:00 am-10:44 am

1 stop4h 44m

$282

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Thu 2/19

7:35 am-4:17 pm

1 stop7h 42m

Knoxville McGhee Tyson

Tue 2/24

11:50 am-7:33 pm

1 stop8h 43m

$293

Des MoinesGreensboro

DSM - GSO

DSMGSO

Des Moines

Thu 2/19

7:45 am-3:18 pm

1 stop6h 33m

Greensboro/H. Point

Mon 2/23

8:15 pm-11:40 pm

1 stop4h 25m

$294

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Tue 3/10

5:30 am-5:40 pm

2 stops11h 10m

Knoxville McGhee Tyson

Tue 3/17

7:50 am-10:05 pm

2 stops15h 15m

$304

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/25

Showing 1-10 of 60 results
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Best time to book a flight from Des Moines to North Carolina

Have a flexible travel schedule? Discover the best time to fly to North Carolina from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to North Carolina

What is the cheapest month to book a flight from Des Moines to North Carolina?

Currently, August is the cheapest month in which you can book a flight from Des Moines to North Carolina (average of $184). Flying from Des Moines to North Carolina in December is currently the most expensive (average of $334). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to NC?

Find hourly flight availability from Des Moines to North Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 27, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to North Carolina as you normally would.

Reviews of airlines servicing North Carolina

Get insights into the airlines that provide service to North Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to North Carolina. Reviews last updated January 27, 2026.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from Des Moines to North Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,268 reviews

Entertainment

7.5

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Southwest
8.0
Very good
4,268 reviews
Southwest
8.0
Very good
4,268 reviews

Entertainment

7.5

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
Delta
7.9
Good
8,118 reviews
Southwest
8.0
Very good
4,268 reviews

Entertainment

7.5

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
United Airlines
7.4
Good
9,205 reviews
Southwest
8.0
Very good
4,268 reviews

Entertainment

7.5

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am
American Airlines
7.2
Good
11,197 reviews
Southwest
8.0
Very good
4,268 reviews

Entertainment

7.5

Crew

8.6

Food

7.0

Overall

8.0

Comfort

8.0

Boarding

8.1

Reviews

1 / 20
2.0
Mediocre

Thomas,Dec 2025

SEA - DEN

Plane two hours late in leaving 1:00 pm west coat time got home next day at 2:45am most car rental places are closed and don’t open till 5am

Related info for your journey

Find useful and relevant information for your journey from Des Moines to North Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to North Carolina?

    Most people fly from Des Moines (DSM) if they book a flight from Des Moines to North Carolina. Des Moines is conveniently located just 3.6 mi from Des Moines’s city center.

  • How long is the flight from Des Moines to North Carolina?

    Departing from Des Moines to North Carolina will take you 4h 18m. Airlines will cover a distance of 827 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Des Moines to North Carolina one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $121. However, be on the lookout for offers from Southwest and United Airlines, as they are both options that can get you from Des Moines to North Carolina for a low price.

  • What are the most popular routes from Des Moines to North Carolina?

    Most travelers choose Des Moines - Charlotte Douglas, Des Moines - Knoxville McGhee Tyson or Des Moines - Raleigh-Durham when deciding on the best route from Des Moines to North Carolina.

  • Can I find deals for flights from Des Moines to North Carolina that include hotel bookings?

    Yes. In addition to deals on Des Moines to North Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to North Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to North Carolina.

  • Can I find deals for business class flights from Des Moines to North Carolina?

    Yes. Cheapflights offers flight deals from Des Moines to North Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to North Carolina?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to North Carolina (average of $184). Flying from Des Moines to North Carolina in December is currently the most expensive (average of $334). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Des Moines to North Carolina

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Des Moines to North Carolina

Discover the top 4 airlines that operate flights from Des Moines to North Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 27, 2026.
AirlineCheapestAverageFlexibilityOn-time
SouthwestCheapest$216Average$386FlexibilityNo cancel feeOn-time63%
DeltaCheapest$216Average$340FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$382FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$276Average$349FlexibilityNo cancel feeOn-time69%

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