What are the cheapest airlines to fly from Des Moines to North Carolina one-way?

The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $118. However, be on the lookout for offers from Frontier and Delta, as they are both options that can get you from Des Moines to North Carolina for a low price.

What are the most popular routes from Des Moines to North Carolina?

Most travelers choose Des Moines - Charlotte Douglas, Des Moines - Myrtle Beach Intl or Des Moines - Knoxville McGhee Tyson when deciding on the best route from Des Moines to North Carolina.

What are the most popular airlines that fly from Des Moines to North Carolina?

Consider American Airlines, Delta or United Airlines when booking your flight. These represent the most popular airlines when flying from Des Moines to North Carolina.

How far in advance should I book a flight from Des Moines to North Carolina?

Find a great deal and save up to 93% by booking at least 25 days prior to your desired departure date, rather than waiting until the week of travel. According to our data, there are a number of flights available from Des Moines to North Carolina within the next two weeks, with the cheapest ticket starting at $342.

What is the cheapest month to fly from Des Moines to North Carolina?

Flights from Des Moines to North Carolina lean towards being more expensive in March. Prices are generally better when you fly from Des Moines to North Carolina in September, with the cheapest ticket starting at $305.

What airport do you fly from for flights from Des Moines to North Carolina?

Most people fly from Des Moines (DSM) if they book a flight from Des Moines to North Carolina. Des Moines is conveniently located just 3.6 mi from Des Moines’s city center.

Can I find deals for flights from Des Moines to North Carolina that include hotel bookings?

Yes. In addition to deals on Des Moines to North Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to North Carolina?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to North Carolina.

Can I find deals for business class flights from Des Moines to North Carolina?

Yes. Cheapflights offers flight deals from Des Moines to North Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$114+ Flights from Des Moines to North Carolina - Compare & Save Big

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Cheap flight deals from Des Moines to North Carolina

Most accurate provider	FlightHub 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$238 (Delta)
One-way from	$114 (Mytrip)
Popular in	March
Cheapest in	September
Average price	$386
Good round-trip deal	$351 or less
Good one-way deal	$148 or less

Provider with most accurate pricing for Des Moines-Charlotte Douglas flight deals.

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Provider most trusted by Cheapflights users for Des Moines-Charlotte Douglas flights.

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From Des Moines to North Carolina

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One-way flight from Des Moines to North Carolina

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Highest demand for flights based on searches. 1% potential increase in price ($8 potential increase over avg. RT price).

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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).

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Average for round-trip flights in May 2025

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Price to beat on a round-trip flight from Des Moines to North Carolina.

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Price to beat on a one-way flight from Des Moines to North Carolina.

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Find flight deals from Des Moines to North Carolina

Cheapest flights from Des Moines to North Carolina
Explore the most affordable flight options available from Des Moines to North Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Sat 5/245:30 pmDSM - TYS

1 stop4h 34mDelta

Thu 5/2911:10 amTYS - DSM

1 stop8h 56mDelta

Deal found 4/30

$248

Tue 7/15:45 amDSM - ILM

1 stop7h 02mDelta

Mon 7/710:23 amILM - DSM

1 stop4h 16mDelta

Deal found 4/29

$248

Thu 9/41:10 pmDSM - GSO

1 stop6h 49mUnited Airlines

Sun 9/76:37 amGSO - DSM

1 stop5h 02mUnited Airlines

Deal found 4/30

$249

Sun 5/1812:32 pmDSM - CLT

1 stop26h 05mMultiple Airlines

Fri 5/2311:23 amCLT - DSM

2 stops11h 14mMultiple Airlines

Deal found 4/30

$250

Thu 5/155:15 amDSM - GSO

1 stop6h 23mAmerican Airlines

Mon 5/195:34 pmGSO - DSM

1 stop6h 22mAmerican Airlines

Deal found 4/30

$259

Sat 7/265:26 pmDSM - ILM

1 stop5h 33mAmerican Airlines

Wed 7/307:47 pmILM - DSM

1 stop4h 14mAmerican Airlines

Deal found 4/30

$259

Sun 6/156:32 pmDSM - ILM

2 stops15h 49mMultiple Airlines

Wed 6/188:00 amILM - DSM

1 stop28h 49mMultiple Airlines

Deal found 4/30

$263

Sat 7/123:47 pmDSM - TYS

1 stop5h 05mAmerican Airlines

Sat 7/196:00 pmTYS - DSM

2 stops6h 44mAmerican Airlines

Deal found 4/30

$265

Fri 6/68:38 pmDSM - RDU

1 stop18h 55mFrontier

Sun 6/85:18 pmRDU - DSM

1 stop27h 35mFrontier

Deal found 4/29

$268

Tue 8/53:35 pmDSM - ORF

1 stop6h 21mAmerican Airlines

Tue 8/126:26 amORF - DSM

1 stop6h 47mAmerican Airlines

Deal found 4/30

$271

Wed 5/287:01 amDSM - MYR

1 stop6h 09mDelta

Wed 6/412:35 pmMYR - DSM

1 stop7h 31mDelta

Deal found 4/30

$271

Thu 7/245:17 pmDSM - AVL

1 stop5h 41mAmerican Airlines

Sun 7/277:45 pmAVL - DSM

1 stop4h 16mAmerican Airlines

Deal found 4/29

$274

Best flights from Des Moines to North Carolina
Discover carefully curated flight deals from Des Moines to North Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 1, 2025.

Thu 5/296:35 pmDSM - AVL

1 stop4h 09mDelta

Thu 6/125:45 amAVL - DSM

2 stops9h 18mDelta

Deal found 4/29

$238

Sun 5/1812:32 pmDSM - CLT

1 stop26h 05mMultiple Airlines

Fri 5/2311:23 amCLT - DSM

2 stops11h 14mMultiple Airlines

Deal found 4/30

$250

Thu 5/155:15 amDSM - GSO

1 stop6h 23mAmerican Airlines

Mon 5/195:34 pmGSO - DSM

1 stop6h 22mAmerican Airlines

Deal found 4/30

$259

Fri 6/68:38 pmDSM - RDU

1 stop18h 55mFrontier

Sun 6/85:18 pmRDU - DSM

1 stop27h 35mFrontier

Deal found 4/29

$268

Tue 5/278:00 amDSM - RDU

2 stops7h 44mUnited Airlines

Tue 6/310:20 amRDU - DSM

1 stop6h 58mUnited Airlines

Deal found 4/29

$276

Thu 5/83:59 pmDSM - TYS

1 stop21h 28mAllegiant Air

Wed 5/145:02 pmTYS - DSM

2 stops19h 40mAllegiant Air

Deal found 4/30

$294

Thu 7/245:25 amDSM - RDU

2 stops7h 55mSouthwest

Wed 7/307:35 amRDU - DSM

1 stop4h 25mSouthwest

Deal found 4/29

$337

Sat 5/245:30 pmDSM - TYS

1 stop4h 34mDelta

Thu 5/2911:10 amTYS - DSM

1 stop8h 56mDelta

Deal found 4/30

$248

Sat 7/265:26 pmDSM - ILM

1 stop5h 33mAmerican Airlines

Wed 7/307:47 pmILM - DSM

1 stop4h 14mAmerican Airlines

Deal found 4/30

$259

Sun 6/156:32 pmDSM - ILM

2 stops15h 49mMultiple Airlines

Wed 6/188:00 amILM - DSM

1 stop28h 49mMultiple Airlines

Deal found 4/30

$263

Tue 7/15:45 amDSM - ILM

1 stop7h 02mDelta

Mon 7/710:23 amILM - DSM

1 stop4h 16mDelta

Deal found 4/29

$248

Thu 5/83:34 pmDSM - TYS

1 stop6h 11mUnited Airlines

Wed 5/147:00 amTYS - DSM

1 stop4h 30mUnited Airlines

Deal found 4/30

$284

Last-minute flights from Des Moines to North Carolina
Discover last-minute flight deals from Des Moines to North Carolina. Data last updated May 1, 2025 and is based on user searches.

Wed 5/76:35 pmDSM - MYR

1 stop4h 24mDelta

Sun 5/113:10 pmMYR - DSM

1 stop6h 56mDelta

Deal found 4/30

$622

Wed 5/75:32 amDSM - MYR

2 stops8h 56mAmerican Airlines

Sun 5/115:00 amMYR - DSM

2 stops9h 48mAmerican Airlines

Deal found 4/30

$632

Thu 5/83:34 pmDSM - TYS

1 stop6h 11mUnited Airlines

Wed 5/147:00 amTYS - DSM

1 stop4h 30mUnited Airlines

Deal found 4/30

$284

Thu 5/83:59 pmDSM - TYS

1 stop21h 28mAllegiant Air

Wed 5/145:02 pmTYS - DSM

2 stops19h 40mAllegiant Air

Deal found 4/30

$294

Thu 5/83:59 pmDSM - TYS

1 stop21h 28mMultiple Airlines

Wed 5/147:10 amTYS - DSM

3 stops29h 32mMultiple Airlines

Deal found 4/30

$319

Fri 5/97:00 amDSM - CLT

1 stop9h 25mSouthwest

Tue 5/131:55 pmCLT - DSM

2 stops9h 10mSouthwest

Deal found 4/30

$422

Sun 5/116:45 amDSM - CLT

Nonstop2h 20mAmerican Airlines

Mon 5/1210:27 pmCLT - DSM

Nonstop2h 31mAmerican Airlines

Deal found 4/30

$475

Sun 5/116:35 pmDSM - CLT

1 stop4h 17mDelta

Mon 5/129:33 amCLT - DSM

1 stop4h 52mDelta

Deal found 4/30

$495

Sun 5/115:45 amDSM - CLT

1 stop8h 30mUnited Airlines

Mon 5/1210:24 amCLT - DSM

2 stops12h 28mUnited Airlines

Deal found 4/30

$570

Mon 5/122:28 pmDSM - ORF

2 stops19h 01mMultiple Airlines

Thu 5/1512:13 pmORF - DSM

2 stops33h 42mMultiple Airlines

Deal found 4/29

$274

Thu 5/155:15 amDSM - GSO

1 stop6h 23mAmerican Airlines

Mon 5/195:34 pmGSO - DSM

1 stop6h 22mAmerican Airlines

Deal found 4/30

$259

Thu 5/1512:32 pmDSM - ILM

1 stop5h 01mMultiple Airlines

Mon 5/197:00 amILM - DSM

1 stop9h 53mMultiple Airlines

Deal found 4/29

$292

One-way flights from Des Moines to North Carolina
Search for one-way flight options from Des Moines to North Carolina. Find affordable one-way fares based on user searches. Data last updated May 1, 2025.

Mon 6/168:35 amDSM - RDU

1 stop8h 46mMultiple Airlines

Deal found 4/30

$114

Fri 5/167:30 amDSM - TYS

1 stop9h 42mAllegiant Air

Deal found 5/1

$118

Wed 5/217:30 pmDSM - RDU

1 stop20h 02mFrontier

Deal found 4/30

$126

Wed 7/210:18 amDSM - ORF

1 stop5h 00mDelta

Deal found 4/30

$136

Sun 5/255:35 amDSM - RDU

1 stop4h 43mDelta

Deal found 4/30

$136

Tue 6/106:47 pmDSM - MYR

1 stop4h 20mDelta

Deal found 4/30

$136

Sat 5/245:50 amDSM - RDU

2 stops7h 10mAmerican Airlines

Deal found 4/30

$141

Tue 6/106:00 amDSM - MYR

2 stops10h 14mAmerican Airlines

Deal found 4/30

$141

Sat 8/238:35 amDSM - RDU

2 stops6h 30mSouthwest

Deal found 4/30

$154

Wed 6/256:25 amDSM - CLT

2 stops8h 40mSouthwest

Deal found 4/30

$154

Mon 8/186:24 amDSM - RDU

2 stops6h 49mUnited Airlines

Deal found 4/30

$157

Mon 6/308:38 pmDSM - CLT

1 stop18h 55mFrontier

Deal found 4/30

$162

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to North Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesAsheville

DSM - AVL

DSMAVL

Des Moines

Thu 5/29

6:35 pm-11:44 pm

1 stop4h 09m

Asheville Regional

Thu 6/12

5:45 am-2:03 pm

2 stops9h 18m

$238

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 5/24

5:30 pm-11:04 pm

1 stop4h 34m

Knoxville McGhee Tyson

Thu 5/29

11:10 am-7:06 pm

1 stop8h 56m

$248

Des MoinesWilmington

DSM - ILM

DSMILM

Des Moines

Tue 7/1

5:45 am-1:47 pm

1 stop7h 02m

Wilmington New Hanover County

Mon 7/7

10:23 am-1:39 pm

1 stop4h 16m

$248

Des MoinesCharlotte

DSM - CLT

DSMCLT

Des Moines

Sun 5/18

12:32 pm-3:37 pm

1 stop26h 05m

Charlotte Douglas

Fri 5/23

11:23 am-9:37 pm

2 stops11h 14m

$250

Des MoinesGreensboro

DSM - GSO

DSMGSO

Des Moines

Thu 5/15

5:15 am-12:38 pm

1 stop6h 23m

Greensboro/H. Point

Mon 5/19

5:34 pm-10:56 pm

1 stop6h 22m

$259

Des MoinesWilmington

DSM - ILM

DSMILM

Des Moines

Sat 7/26

5:26 pm-11:59 pm

1 stop5h 33m

Wilmington New Hanover County

Wed 7/30

7:47 pm-11:01 pm

1 stop4h 14m

$259

Des MoinesWilmington

DSM - ILM

DSMILM

Des Moines

Sun 6/15

6:32 pm-11:21 am

2 stops15h 49m

Wilmington New Hanover County

Wed 6/18

8:00 am-11:49 am

1 stop28h 49m

$263

Des MoinesKnoxville

DSM - TYS

DSMTYS

Des Moines

Sat 7/12

3:47 pm-9:52 pm

1 stop5h 05m

Knoxville McGhee Tyson

Sat 7/19

6:00 pm-11:44 pm

2 stops6h 44m

$265

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Fri 6/6

8:38 pm-4:33 pm

1 stop18h 55m

Raleigh-Durham

Sun 6/8

5:18 pm-7:53 pm

1 stop27h 35m

$268

Des MoinesRaleigh

DSM - RDU

DSMRDU

Des Moines

Tue 6/3

10:59 am-6:10 pm

1 stop6h 11m

Raleigh-Durham

Tue 6/10

1:21 pm-7:17 pm

1 stop6h 56m

$271

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 57 results

...

Best time to book a flight from Des Moines to North Carolina

Have a flexible travel schedule? Discover the best time to fly to North Carolina from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to North Carolina

What is the cheapest month to book a flight from Des Moines to North Carolina?

Currently, August is the cheapest month in which you can book a flight from Des Moines to North Carolina (average of $206). Flying from Des Moines to North Carolina in March is currently the most expensive (average of $294). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to NC?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to North Carolina as you normally would.

Rainfall in North Carolina by month

In terms of precipitation, rainfall in North Carolina ranges from 3.0 - 4.2 inches per month. August is typically the wettest month, when rainfall can reach 4.2 in. April is typically the driest time to visit North Carolina when rainfall is around 3.0 in.

Temperature in North Carolina by month

If weather is an important factor for your trip to North Carolina, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 41.0 F).

Reviews of airlines servicing North Carolina

To help decide which airline to fly from Des Moines to North Carolina, see what other customers have to say about Southwest, Delta and United Airlines. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,294 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Southwest

8.0

Very good

4,294 reviews

Southwest

8.0

Very good

4,294 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Delta

8.0

Very good

7,934 reviews

Southwest

8.0

Very good

4,294 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

United Airlines

7.4

Good

8,696 reviews

Southwest

8.0

Very good

4,294 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Allegiant Air

7.3

Good

734 reviews

Southwest

8.0

Very good

4,294 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

American Airlines

7.2

Good

10,000 reviews

Southwest

8.0

Very good

4,294 reviews

Reviews

1 / 20

10.0

Excellent

Gina,Apr 2025

LAS - DEN

Good, the crew was friendly and helpful. The pilot had great skills in keeping the plane stable through rough turbulence. Smooth landing, too! Thank you!

Related info for your journey

What airport do you fly from for flights from Des Moines to North Carolina?
Most people fly from Des Moines (DSM) if they book a flight from Des Moines to North Carolina. Des Moines is conveniently located just 3.6 mi from Des Moines’s city center.
What are the cheapest airlines to fly from Des Moines to North Carolina one-way?
The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $118. However, be on the lookout for offers from Frontier and Delta, as they are both options that can get you from Des Moines to North Carolina for a low price.
What are the most popular routes from Des Moines to North Carolina?
Most travelers choose Des Moines - Charlotte Douglas, Des Moines - Myrtle Beach Intl or Des Moines - Knoxville McGhee Tyson when deciding on the best route from Des Moines to North Carolina.
Can I find deals for flights from Des Moines to North Carolina that include hotel bookings?
Yes. In addition to deals on Des Moines to North Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to North Carolina?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to North Carolina.
Can I find deals for business class flights from Des Moines to North Carolina?
Yes. Cheapflights offers flight deals from Des Moines to North Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to North Carolina?
Currently, August is the cheapest month in which you can book a flight from Des Moines to North Carolina (average of $206). Flying from Des Moines to North Carolina in March is currently the most expensive (average of $294). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 4 airlines flying from Des Moines to North Carolina

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$131	Average$340	FlexibilityNo cancel fee	On-timeN/A
American Airlines	Cheapest$208	Average$358	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$229	Average$422	FlexibilityNo cancel fee	On-time69%
Southwest	Cheapest$312	Average$431	FlexibilityNo cancel fee	On-time63%

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$114+ Cheap flights from Des Moines (DSM) to North Carolina

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/16. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to North Carolina with Cheapflights

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Cheap flight deals from Des Moines to North Carolina

Keep the following information in mind while searching for Des Moines to North Carolina flight deals. Data was last updated May 1, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from Des Moines to North Carolina

Cheapest flights from Des Moines to North CarolinaExplore the most affordable flight options available from Des Moines to North Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Explore the most affordable flight options available from Des Moines to North Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to North Carolina that are best for you.

Best time to book a flight from Des Moines to North Carolina

Have a flexible travel schedule? Discover the best time to fly to North Carolina from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to North Carolina

What is the cheapest month to book a flight from Des Moines to North Carolina?

What is the cheapest time of day to fly from DSM to NC?

Find hourly flight availability from Des Moines to North Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Rainfall in North Carolina by month

Plan your trip to North Carolina by taking into account the average rainfall totals by month.

Temperature in North Carolina by month

Plan your trip to North Carolina by taking into account the average temperature totals by month.

Reviews of airlines servicing North Carolina

Related info for your journey

Find useful and relevant information for your journey from Des Moines to North Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly from for flights from Des Moines to North Carolina?

What are the cheapest airlines to fly from Des Moines to North Carolina one-way?

What are the most popular routes from Des Moines to North Carolina?

Can I find deals for flights from Des Moines to North Carolina that include hotel bookings?

How can I find direct flights from Des Moines to North Carolina?

Can I find deals for business class flights from Des Moines to North Carolina?

What is the cheapest month to book a flight from Des Moines to North Carolina?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to North Carolina

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Des Moines to North Carolina

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Cheapest flights from Des Moines to North Carolina
Explore the most affordable flight options available from Des Moines to North Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.