$86+ Cheap flights from Des Moines (DSM) to North Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — RDU
Apr 11 — Apr 181
Round-trip
1 adult, Economy
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Cheapest flights from Des Moines to North CarolinaExplore the most affordable flight options available from Des Moines to North Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 12, 2026.
Explore the most affordable flight options available from Des Moines to North Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 12, 2026.
This CheapOair deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/12:04 pm
DSM
- CLT
1 stop25h 52m
Frontier
Tue 5/55:20 pm
CLT
- DSM
1 stop21h 11m
Frontier
Deal found 3/11![Frontier logo]()
$191
This CheapOair deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:20 pm
DSM
- CLT
1 stop25h 32m
Frontier
Sun 5/107:49 pm
CLT
- DSM
1 stop18h 40m
Frontier
Deal found 3/9![Frontier logo]()
$226
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- CLT
1 stop21h 13m
Multiple Airlines
Thu 6/43:49 pm
CLT
- DSM
1 stop6h 38m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2010:26 am
DSM
- CLT
1 stop21h 34m
Multiple Airlines
Tue 3/249:00 pm
CLT
- DSM
2 stops48h 43m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$256
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:00 am
DSM
- AVL
1 stop15h 23m
Multiple Airlines
Wed 3/253:25 pm
AVL
- DSM
2 stops30h 18m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:00 am
DSM
- AVL
1 stop15h 23m
Allegiant Air
Wed 3/253:25 pm
AVL
- DSM
1 stop23h 04m
Allegiant Air
Deal found 3/8![Allegiant Air logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/284:41 pm
DSM
- CLT
1 stop21h 13m
Multiple Airlines
Wed 6/39:54 pm
CLT
- DSM
2 stops24h 33m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$269
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/272:59 pm
DSM
- TYS
1 stop22h 59m
Allegiant Air
Thu 4/303:40 pm
TYS
- DSM
1 stop7h 26m
Allegiant Air
Deal found 3/9![Allegiant Air logo]()
$271
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/73:21 pm
DSM
- RDU
1 stop5h 02m
United Airlines
Tue 4/145:25 pm
RDU
- DSM
1 stop6h 52m
United Airlines
Deal found 3/10![United Airlines logo]()
$271
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/37:40 pm
DSM
- TYS
1 stop17h 29m
Allegiant Air
Sun 4/57:30 am
TYS
- DSM
1 stop7h 16m
Allegiant Air
Deal found 3/7![Allegiant Air logo]()
$275
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:30 am
DSM
- RDU
2 stops10h 00m
Southwest
Tue 4/145:40 am
RDU
- DSM
1 stop9h 25m
Southwest
Deal found 3/10![Southwest logo]()
$276
This Kiwi.com deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/13:57 pm
DSM
- RDU
1 stop21h 15m
Multiple Airlines
Sat 6/67:52 pm
RDU
- DSM
2 stops28h 00m
Multiple Airlines
Deal found 3/11![Multiple Airlines logo]()
$277
Best flights from Des Moines to North CarolinaDiscover carefully curated flight deals from Des Moines to North Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 12, 2026.
Discover carefully curated flight deals from Des Moines to North Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:00 am
DSM
- AVL
1 stop15h 23m
Multiple Airlines
Wed 3/253:25 pm
AVL
- DSM
2 stops30h 18m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$264
This Southwest deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/234:20 pm
DSM
- RDU
1 stop4h 25m
Southwest
Thu 4/307:45 pm
RDU
- DSM
1 stop4h 20m
Southwest
Deal found 3/9![Southwest logo]()
$287
This Delta deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/236:30 pm
DSM
- GSO
1 stop4h 27m
Delta
Tue 6/305:25 am
GSO
- DSM
1 stop5h 49m
Delta
Deal found 3/9![Delta logo]()
$289
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/73:21 pm
DSM
- TYS
1 stop6h 13m
United Airlines
Tue 4/147:00 am
TYS
- DSM
1 stop4h 44m
United Airlines
Deal found 3/8![United Airlines logo]()
$291
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3011:09 am
DSM
- AVL
1 stop6h 21m
American Airlines
Tue 5/56:40 am
AVL
- DSM
2 stops8h 06m
American Airlines
Deal found 3/9![American Airlines logo]()
$299
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/142:44 pm
DSM
- AVL
1 stop6h 49m
Delta
Sat 4/185:43 am
AVL
- DSM
1 stop6h 22m
Delta
Deal found 3/7![Delta logo]()
$289
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:00 am
DSM
- AVL
2 stops8h 03m
American Airlines
Sat 4/184:13 pm
AVL
- DSM
2 stops8h 46m
American Airlines
Deal found 3/7![American Airlines logo]()
$300
This United Airlines deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/133:21 pm
DSM
- RDU
2 stops7h 23m
United Airlines
Mon 4/208:00 am
RDU
- DSM
1 stop9h 15m
United Airlines
Deal found 3/12![United Airlines logo]()
$309
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/237:51 pm
DSM
- AVL
1 stop18h 37m
Multiple Airlines
Fri 3/276:00 am
AVL
- DSM
1 stop14h 16m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$310
This Southwest deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/95:35 am
DSM
- ORF
1 stop4h 15m
Southwest
Wed 5/136:25 pm
ORF
- DSM
1 stop4h 45m
Southwest
Deal found 3/9![Southwest logo]()
$328
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:35 am
DSM
- GSO
1 stop6h 56m
Delta
Sun 4/125:19 am
GSO
- DSM
1 stop6h 29m
Delta
Deal found 3/11![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/195:00 am
DSM
- AVL
1 stop7h 27m
United Airlines
Sat 5/235:33 pm
AVL
- DSM
1 stop5h 07m
United Airlines
Deal found 3/11![United Airlines logo]()
$309
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/105:00 am
DSM
- ILM
1 stop5h 12m
American Airlines
Sat 8/157:06 pm
ILM
- DSM
1 stop5h 51m
American Airlines
Deal found 3/9![American Airlines logo]()
$325
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:25 am
DSM
- RDU
1 stop11h 05m
Southwest
Sat 5/98:00 am
RDU
- DSM
1 stop4h 30m
Southwest
Deal found 3/7![Southwest logo]()
$338
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/276:41 pm
DSM
- AVL
1 stop3h 58m
Delta
Wed 6/312:22 pm
AVL
- DSM
1 stop8h 12m
Delta
Deal found 3/10![Delta logo]()
$309
This United Airlines deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/291:05 pm
DSM
- TYS
1 stop6h 51m
United Airlines
Tue 8/48:48 am
TYS
- DSM
1 stop8h 27m
United Airlines
Deal found 3/11![United Airlines logo]()
$311
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/296:41 pm
DSM
- AVL
1 stop3h 58m
Delta
Thu 6/45:45 am
AVL
- DSM
1 stop6h 23m
Delta
Deal found 3/10![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/63:35 pm
DSM
- CLT
1 stop4h 10m
Southwest
Wed 6/107:05 pm
CLT
- DSM
1 stop4h 40m
Southwest
Deal found 3/10![Southwest logo]()
$341
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/83:30 pm
DSM
- TYS
1 stop4h 15m
United Airlines
Tue 5/129:50 am
TYS
- DSM
2 stops12h 33m
United Airlines
Deal found 3/8![United Airlines logo]()
$319
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/251:50 pm
DSM
- FAY
2 stops9h 06m
American Airlines
Wed 4/296:11 pm
FAY
- DSM
1 stop5h 07m
American Airlines
Deal found 3/10![American Airlines logo]()
$364
This Southwest deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:20 pm
DSM
- RDU
1 stop4h 25m
Southwest
Tue 4/286:10 am
RDU
- DSM
2 stops8h 55m
Southwest
Deal found 3/8![Southwest logo]()
$342
This Delta deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/272:33 pm
DSM
- TYS
1 stop6h 15m
Delta
Wed 6/36:36 am
TYS
- DSM
1 stop4h 40m
Delta
Deal found 3/10![Delta logo]()
$311
This United Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/111:40 am
DSM
- TYS
1 stop4h 09m
United Airlines
Mon 5/46:01 pm
TYS
- DSM
1 stop6h 23m
United Airlines
Deal found 3/7![United Airlines logo]()
$328
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/98:03 pm
DSM
- GSO
1 stop14h 06m
American Airlines
Mon 4/138:17 pm
GSO
- DSM
1 stop4h 32m
American Airlines
Deal found 3/7![American Airlines logo]()
$372
This Southwest deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:40 am
DSM
- ORF
2 stops9h 00m
Southwest
Sat 5/27:55 am
ORF
- DSM
1 stop4h 35m
Southwest
Deal found 3/7![Southwest logo]()
$342
This Delta deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/275:20 pm
DSM
- GSO
1 stop5h 39m
Delta
Tue 3/316:35 am
GSO
- DSM
1 stop5h 13m
Delta
Deal found 3/12![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/276:20 am
DSM
- MYR
1 stop6h 57m
United Airlines
Sat 5/23:14 pm
MYR
- DSM
1 stop7h 11m
United Airlines
Deal found 3/8![United Airlines logo]()
$335
This American Airlines deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/231:52 pm
DSM
- ILM
1 stop7h 03m
American Airlines
Wed 4/17:27 am
ILM
- DSM
1 stop6h 38m
American Airlines
Deal found 3/7![American Airlines logo]()
$374
This Southwest deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/295:20 am
DSM
- TYS
2 stops5h 45m
Southwest
Tue 8/41:55 pm
TYS
- DSM
2 stops9h 00m
Southwest
Deal found 3/11![Southwest logo]()
$350
This Delta deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/305:20 pm
DSM
- MYR
1 stop5h 44m
Delta
Tue 3/316:00 am
MYR
- DSM
1 stop5h 48m
Delta
Deal found 3/7![Delta logo]()
$335
Last-minute flights from Des Moines to North CarolinaDiscover last-minute flight deals from Des Moines to North Carolina. Data last updated March 12, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to North Carolina. Data last updated March 12, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2010:26 am
DSM
- CLT
1 stop21h 34m
Multiple Airlines
Tue 3/249:00 pm
CLT
- DSM
2 stops48h 43m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$256
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:00 am
DSM
- AVL
1 stop15h 23m
Multiple Airlines
Wed 3/253:25 pm
AVL
- DSM
2 stops30h 18m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/227:00 am
DSM
- AVL
1 stop15h 23m
Allegiant Air
Wed 3/253:25 pm
AVL
- DSM
1 stop23h 04m
Allegiant Air
Deal found 3/8![Allegiant Air logo]()
$265
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/2310:20 am
DSM
- CLT
1 stop20h 43m
Multiple Airlines
Wed 3/258:56 am
CLT
- DSM
2 stops36h 47m
Multiple Airlines
Deal found 3/9![Multiple Airlines logo]()
$277
This American Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/311:48 pm
DSM
- RDU
1 stop5h 49m
American Airlines
Thu 4/24:20 pm
RDU
- DSM
1 stop6h 39m
American Airlines
Deal found 3/10![American Airlines logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 3/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/23:21 pm
DSM
- CLT
1 stop8h 17m
Multiple Airlines
Thu 4/91:20 pm
CLT
- DSM
1 stop9h 46m
Multiple Airlines
Deal found 3/12![Multiple Airlines logo]()
$278
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/37:40 pm
DSM
- TYS
1 stop17h 29m
Allegiant Air
Sun 4/57:30 am
TYS
- DSM
1 stop7h 16m
Allegiant Air
Deal found 3/7![Allegiant Air logo]()
$275
This United Airlines deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/73:21 pm
DSM
- RDU
1 stop5h 02m
United Airlines
Tue 4/145:25 pm
RDU
- DSM
1 stop6h 52m
United Airlines
Deal found 3/10![United Airlines logo]()
$271
This Southwest deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/75:30 am
DSM
- RDU
2 stops10h 00m
Southwest
Tue 4/145:40 am
RDU
- DSM
1 stop9h 25m
Southwest
Deal found 3/10![Southwest logo]()
$276
This Delta deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/711:33 am
DSM
- TYS
1 stop3h 33m
Delta
Tue 4/148:45 am
TYS
- DSM
1 stop6h 10m
Delta
Deal found 3/11![Delta logo]()
$279
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:04 pm
DSM
- RDU
1 stop30h 00m
Multiple Airlines
Wed 4/294:00 pm
RDU
- DSM
2 stops31h 06m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$278
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/272:59 pm
DSM
- TYS
1 stop22h 59m
Allegiant Air
Thu 4/303:40 pm
TYS
- DSM
1 stop7h 26m
Allegiant Air
Deal found 3/9![Allegiant Air logo]()
$271
One-way flights from Des Moines to North CarolinaSearch for one-way flight options from Des Moines to North Carolina. Find affordable one-way fares based on user searches. Data last updated March 12, 2026.
Search for one-way flight options from Des Moines to North Carolina. Find affordable one-way fares based on user searches. Data last updated March 12, 2026.
This Travelocity deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/258:21 pm
DSM
- RDU
1 stop20h 27m
Frontier
Deal found 3/8![Frontier logo]()
$86
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/286:56 pm
DSM
- RDU
1 stop12h 51m
Frontier
Deal found 3/10![Frontier logo]()
$87
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/267:00 am
DSM
- RDU
1 stop30h 43m
Multiple Airlines
Deal found 3/10![Multiple Airlines logo]()
$88
This Trip.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:23 pm
DSM
- RDU
1 stop19h 42m
Frontier
Deal found 3/9![Frontier logo]()
$89
This CheapOair deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/82:20 pm
DSM
- CLT
1 stop25h 32m
Frontier
Deal found 3/8![Frontier logo]()
$92
This Kiwi.com deal was found by Cheapflights users on 3/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1910:40 am
DSM
- CLT
1 stop20h 18m
Frontier
Deal found 3/10![Frontier logo]()
$94
This Mytrip deal was found by Cheapflights users on 3/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/272:04 pm
DSM
- RDU
1 stop27h 40m
Frontier
Deal found 3/11![Frontier logo]()
$100
This Expedia deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/1710:40 am
DSM
- RDU
1 stop20h 12m
Frontier
Deal found 3/8![Frontier logo]()
$107
This Trip.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/1910:40 am
DSM
- RDU
1 stop10h 13m
Frontier
Deal found 3/7![Frontier logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 3/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/37:00 am
DSM
- RDU
1 stop6h 43m
Multiple Airlines
Deal found 3/8![Multiple Airlines logo]()
$113
This Vakatrip deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Vakatrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:04 pm
DSM
- CLT
1 stop25h 52m
Frontier
Deal found 3/9![Frontier logo]()
$118
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/132:03 pm
DSM
- TYS
1 stop23h 55m
Allegiant Air
Deal found 3/9![Allegiant Air logo]()
$121
Find flight deals from Des Moines to North Carolina
Keep the following information in mind while searching for Des Moines to North Carolina flight deals. Data was last updated March 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $191 (CheapOair) |
One-way from | $86 (Travelocity) |
Popular in | December |
Cheapest in | September |
Average price | $383 |
Good round-trip deal | $386 or less |
Good one-way deal | $243 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to North Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
Use the filters below to find and compare flights from Des Moines to North Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesAsheville
DSM - AVL
DSMAVL
Des Moines
Sun 3/22
7:00 am-11:23 pm
1 stop15h 23m
Asheville Regional
Wed 3/25
3:25 pm-8:43 pm
2 stops30h 18m
$264
Quickest round-trip
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Thu 4/23
4:20 pm-9:45 pm
1 stop4h 25m
Raleigh-Durham
Thu 4/30
7:45 pm-11:05 pm
1 stop4h 20m
$287
Des MoinesGreensboro
DSM - GSO
DSMGSO
Des Moines
Tue 6/23
6:30 pm-11:57 pm
1 stop4h 27m
Greensboro/H. Point
Tue 6/30
5:25 am-10:14 am
1 stop5h 49m
$289
Des MoinesAsheville
DSM - AVL
DSMAVL
Des Moines
Tue 4/14
2:44 pm-10:33 pm
1 stop6h 49m
Asheville Regional
Sat 4/18
5:43 am-11:05 am
1 stop6h 22m
$289
Des MoinesKnoxville
DSM - TYS
DSMTYS
Des Moines
Tue 4/7
3:21 pm-10:34 pm
1 stop6h 13m
Knoxville McGhee Tyson
Tue 4/14
7:00 am-10:44 am
1 stop4h 44m
$291
Des MoinesAsheville
DSM - AVL
DSMAVL
Des Moines
Thu 4/30
11:09 am-6:30 pm
1 stop6h 21m
Asheville Regional
Tue 5/5
6:40 am-1:46 pm
2 stops8h 06m
$299
Des MoinesAsheville
DSM - AVL
DSMAVL
Des Moines
Tue 4/14
6:00 am-3:03 pm
2 stops8h 03m
Asheville Regional
Sat 4/18
4:13 pm-11:59 pm
2 stops8h 46m
$300
Des MoinesRaleigh
DSM - RDU
DSMRDU
Des Moines
Mon 4/13
3:21 pm-11:44 pm
2 stops7h 23m
Raleigh-Durham
Mon 4/20
8:00 am-4:15 pm
1 stop9h 15m
$309
Des MoinesGreensboro
DSM - GSO
DSMGSO
Des Moines
Wed 4/8
5:35 am-1:31 pm
1 stop6h 56m
Greensboro/H. Point
Sun 4/12
5:19 am-10:48 am
1 stop6h 29m
$309
Des MoinesAsheville
DSM - AVL
DSMAVL
Des Moines
Tue 5/19
5:00 am-1:27 pm
1 stop7h 27m
Asheville Regional
Sat 5/23
5:33 pm-9:40 pm
1 stop5h 07m
$309
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Des Moines to North Carolina
Have a flexible travel schedule? Discover the best time to fly to North Carolina from Des Moines with our price prediction graph.
DSM-CLT
DSM-AVL
DSM-TYS
DSM-RDU
DSM-GSO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to North Carolina
DSM-USNC
DSM-CLT
DSM-AVL
DSM-TYS
DSM-RDU
What is the cheapest month to book a flight from Des Moines to North Carolina?
Currently, August is the cheapest month in which you can book a flight from Des Moines to North Carolina (average of $184). Flying from Des Moines to North Carolina in December is currently the most expensive (average of $334). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from DSM to NC?
Find hourly flight availability from Des Moines to North Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 12, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to North Carolina as you normally would.
Reviews of airlines servicing North Carolina
Get insights into the airlines that provide service to North Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to North Carolina. Reviews last updated March 12, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from Des Moines to North Carolina to help guide your decision. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Comfort
8.0
Entertainment
7.5
Boarding
8.1
Overall
8.0
Food
7.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentAnonymous,Mar 2026
KOA - HNL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to North Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Des Moines to North Carolina
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Complete your trip
Complete your trip to North Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Des Moines to North Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and North Carolina flights
Browse other Des Moines and North Carolina flight options. Last updated on March 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Des Moines to North Carolina flights
Consider these flights traveling from Des Moines to North Carolina.
Top 4 airlines flying from Des Moines to North Carolina
Discover the top 4 airlines that operate flights from Des Moines to North Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$216 | Average$386 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$228 | Average$396 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$248 | Average$357 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$276 | Average$349 | FlexibilityNo cancel fee | On-time69% |