$131+ Cheap flights from Des Moines (DSM) to Marco Island, FL
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MIA
Oct 15 — Oct 221
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Marco Island with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Marco Island
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Best
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One-way
Cheapest flights from Des Moines to Marco IslandExplore the most affordable flight options available from Des Moines to Marco Island. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2026.
Explore the most affordable flight options available from Des Moines to Marco Island. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/188:43 am -
1 stop10h 02m
Wed 10/213:23 pm -
2 stops24h 19m
Deal found 9/14![Multiple Airlines logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:25 pm -
1 stop27h 22m
Wed 10/2110:36 pm -
2 stops17h 06m
Deal found 9/14![Multiple Airlines logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:25 pm -
1 stop27h 22m
Wed 10/213:23 pm -
2 stops24h 19m
Deal found 9/14![Multiple Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/188:43 am -
1 stop10h 02m
Thu 10/225:15 am -
2 stops12h 47m
Deal found 9/11![Multiple Airlines logo]()
$308
This Trip.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:30 pm -
1 stop27h 16m
Mon 10/125:50 am -
1 stop14h 40m
Deal found 9/15![Frontier logo]()
$313
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/188:43 am -
1 stop10h 02m
Sat 10/245:05 am -
2 stops33h 54m
Deal found 9/14![Multiple Airlines logo]()
$324
This CheapOair deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected ” under the list of providers to see comparable flight deals.
Fri 10/28:30 pm -
1 stop27h 16m
Mon 10/125:50 am -
1 stop14h 40m
Deal found 9/11![Frontier logo]()
$326
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:35 am -
1 stop9h 10m
Tue 10/208:25 am -
2 stops13h 15m
Deal found 9/15![Southwest logo]()
$330
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:25 pm -
1 stop27h 22m
Fri 10/2310:55 pm -
2 stops40h 04m
Deal found 9/14![Multiple Airlines logo]()
$331
Best flights from Des Moines to Marco IslandDiscover carefully curated flight deals from Des Moines to Marco Island that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2026.
Discover carefully curated flight deals from Des Moines to Marco Island that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 15, 2026.
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/73:10 pm -
1 stop5h 30m
Sat 1/166:45 am -
1 stop5h 35m
Deal found 9/10![Southwest logo]()
$439
This United Airlines deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/63:25 pm -
1 stop5h 40m
Tue 3/91:25 pm -
2 stops8h 52m
Deal found 9/12![United Airlines logo]()
$474
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1210:26 am -
1 stop6h 17m
Sat 11/216:00 am -
1 stop9h 08m
Deal found 9/14![Delta logo]()
$501
This Southwest deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/203:30 pm -
1 stop5h 25m
Sat 2/275:25 am -
2 stops9h 00m
Deal found 9/10![Southwest logo]()
$444
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/155:10 am -
2 stops11h 50m
Thu 10/226:40 am -
1 stop5h 30m
Deal found 9/15![Southwest logo]()
$471
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/175:45 am -
1 stop9h 10m
Sat 10/247:00 am -
2 stops11h 48m
Deal found 9/13![United Airlines logo]()
$564
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/286:45 am -
2 stops9h 05m
Sun 3/76:05 pm -
1 stop5h 45m
Deal found 9/13![Southwest logo]()
$538
This Southwest deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/105:50 am -
2 stops13h 45m
Sat 10/175:50 am -
2 stops8h 50m
Deal found 9/12![Southwest logo]()
$543
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/285:20 am -
1 stop10h 35m
Sat 12/52:55 pm -
1 stop5h 45m
Deal found 9/15![Southwest logo]()
$563
This Southwest deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/145:55 am -
2 stops13h 15m
Mon 1/189:05 am -
2 stops13h 15m
Deal found 9/13![Southwest logo]()
$583
This Southwest deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:35 am -
1 stop9h 10m
Sun 10/185:15 am -
2 stops9h 20m
Deal found 9/11![Southwest logo]()
$591
Last-minute flights from Des Moines to Marco IslandDiscover last-minute flight deals from Des Moines to Marco Island. Data last updated September 15, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Marco Island. Data last updated September 15, 2026 and is based on user searches.
This CheapOair deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/28:30 pm -
1 stop27h 16m
Mon 10/125:50 am -
1 stop14h 40m
Deal found 9/11![Frontier logo]()
$326
This Trip.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/58:30 pm -
1 stop27h 16m
Mon 10/125:50 am -
1 stop14h 40m
Deal found 9/15![Frontier logo]()
$313
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:35 am -
1 stop9h 10m
Tue 10/2012:35 pm -
1 stop10h 25m
Deal found 9/15![Southwest logo]()
$330
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/168:25 pm -
1 stop27h 22m
Wed 10/213:23 pm -
2 stops24h 19m
Deal found 9/14![Multiple Airlines logo]()
$307
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/188:43 am -
1 stop10h 02m
Wed 10/213:23 pm -
2 stops24h 19m
Deal found 9/14![Multiple Airlines logo]()
$274
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/188:43 am -
1 stop10h 02m
Thu 10/225:15 am -
2 stops12h 47m
Deal found 9/11![Multiple Airlines logo]()
$308
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/188:43 am -
1 stop10h 02m
Sat 10/245:05 am -
2 stops33h 54m
Deal found 9/14![Multiple Airlines logo]()
$324
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:25 pm -
1 stop27h 22m
Wed 10/2110:36 pm -
2 stops17h 06m
Deal found 9/14![Multiple Airlines logo]()
$292
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/198:25 pm -
1 stop27h 22m
Fri 10/2310:55 pm -
2 stops40h 04m
Deal found 9/14![Multiple Airlines logo]()
$331
One-way flights from Des Moines to Marco IslandSearch for one-way flight options from Des Moines to Marco Island. Find affordable one-way fares based on user searches. Data last updated September 15, 2026.
Search for one-way flight options from Des Moines to Marco Island. Find affordable one-way fares based on user searches. Data last updated September 15, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/18:00 am -
2 stops30h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Multiple Airlines logo]()
$131
This Priceline deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/108:35 pm -
1 stop7h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Frontier logo]()
$149
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/203:10 pm -
1 stop5h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Southwest logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/118:43 am -
2 stops29h 42m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Multiple Airlines logo]()
$152
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/168:30 pm -
1 stop27h 14m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Frontier logo]()
$155
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:00 am -
2 stops9h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Southwest logo]()
$156
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/98:04 pm -
3 stops24h 27m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Multiple Airlines logo]()
$162
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/112:45 pm -
2 stops26h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/11![Multiple Airlines logo]()
$163
Find flight deals from Des Moines to Marco Island
Keep the following information in mind while searching for Des Moines to Marco Island flight deals. Data was last updated September 15, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $274 (Kiwi.com) |
One-way from | $131 (Kiwi.com) |
Popular in | March |
Cheapest in | April |
Average price | $387 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Marco Island that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 15, 2026.
Use the filters below to find and compare flights from Des Moines to Marco Island that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesMiami
DSM Des Moines - MIA Miami
DSMMIA
Des Moines
Wed 11/11
6:00 am-5:25 pm
1 stop10h 25m
Miami
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$157
Des MoinesMiami
DSM Des Moines - MIA Miami
DSMMIA
Des Moines
Wed 10/14
5:35 am-5:30 pm
2 stops10h 55m
Miami
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$219
Des MoinesMiami
DSM Des Moines - MIA Miami
DSMMIA
Des Moines
Tue 11/10
7:00 am-4:50 pm
1 stop8h 50m
Miami
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$235
Quickest round-trip
Des MoinesMiami
DSM Des Moines - MIA Miami
DSMMIA
Des Moines
Fri 2/19
5:00 am-12:58 pm
1 stop6h 58m
Miami
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$337
Des MoinesMiami
DSM Des Moines - MIA Miami
DSMMIA
Des Moines
Sat 10/3
6:00 am-6:52 pm
3 stops11h 52m
Miami
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$372
Des MoinesMiami
DSM Des Moines - MIA Miami
DSMMIA
Des Moines
Fri 12/4
3:20 pm-1:03 pm
2 stops20h 43m
Miami
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$384
Des MoinesMiami
DSM Des Moines - MIA Miami
DSMMIA
Des Moines
Tue 10/13
3:03 pm-9:26 am
1 stop17h 23m
Miami
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$402
Des MoinesMiami
DSM Des Moines - MIA Miami
DSMMIA
Des Moines
Tue 11/10
2:59 pm-12:57 am
1 stop8h 58m
Miami
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$412
Des MoinesMiami
DSM Des Moines - MIA Miami
DSMMIA
Des Moines
Thu 11/12
5:30 am-5:20 pm
1 stop10h 50m
Miami
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$412
Des MoinesMiami
DSM Des Moines - MIA Miami
DSMMIA
Des Moines
Thu 1/7
3:10 pm-9:40 pm
1 stop5h 30m
Miami
Sat 1/16
6:45 am-11:20 am
1 stop5h 35m
$439
Showing 1-10 of 20 resultsSorted by cheapest first
Best time to book a flight from Des Moines to Marco Island
Have a flexible travel schedule? Discover the best time to fly to Marco Island from Des Moines with our price prediction graph.
DSM-MIA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Marco Island
DSM-MA9
DSM-MIA
What is the cheapest time of day to fly from DSM to MA9?
Find hourly flight availability from Des Moines to Marco Island. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2026.
When flying from Des Moines to Marco Island, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 42% versus a flight in the morning.
How much does it cost to fly round-trip from Des Moines to Marco Island?
Airfare is below average for this route at the moment.
Des Moines to Marco Island flights typically cost between $324 and $462 in October.The cheapest round-trip price found within the last 5 days was $274 on Multiple Airlines (Oct 18-Oct 21).
Reviews of airlines servicing Marco Island
Get insights into the airlines that provide service to Marco Island. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Marco Island. Reviews last updated September 15, 2026.
Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Des Moines to Marco Island by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Comfort
8.0
Overall
8.0
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Crew
8.6
Comfort
8.0
Overall
8.0
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Crew
8.6
Comfort
8.0
Overall
8.0
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Crew
8.6
Comfort
8.0
Overall
8.0
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Crew
8.6
Comfort
8.0
Overall
8.0
Entertainment
7.5
Boarding
8.1
Food
7.0
Reviews
1 / 20
6.0
GoodScott,Feb 2026
HOU - FLL
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Marco Island. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Marco Island by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to Marco Island by cabin class
Find flights from Des Moines to Marco Island, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Marco Island flights
Browse other Des Moines and Marco Island flight options. Last updated on September 15, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on September 15, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Des Moines to Marco Island flights
Consider these flights traveling from Des Moines to Marco Island.
Top 5 airlines flying from Des Moines to Marco Island
Discover the top 5 airlines that operate flights from Des Moines to Marco Island. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 15, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$91 | Average$211 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$113 | Average$370 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$237 | Average$432 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$239 | Average$453 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$258 | Average$408 | FlexibilityNo cancel fee | On-time69% |