HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Greenville

$315+ Cheap flights from Des Moines to Greenville (DSM - GSP)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/21. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GSP
Dec 28 — Jan 41
Sun 12/28
Sun 1/4
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Greenville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 28, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$315
(Delta)

Popular in

January

Cheapest in

September

Average price

$581
Provider with most accurate pricing for Des Moines-Greenville flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Greenville flights.
Search Deals
From Des Moines to Greenville
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($73 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 5% potential price decrease ($20 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Find flight deals from Des Moines to Greenville

Cheapest flights from Des Moines to Greenville
Explore the most affordable flight options available from Des Moines to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 28, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/142:56 pmDSM - GSP
1 stop22h 14mMultiple Airlines
Mon 12/298:03 pmGSP - DSM
2 stops36h 38mMultiple Airlines
Deal found 11/27$375
This Kiwi.com deal was found by Cheapflights users on 11/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:56 pmDSM - GSP
1 stop22h 14mMultiple Airlines
Sun 12/144:00 pmGSP - DSM
2 stops28h 03mMultiple Airlines
Deal found 11/28$379
This United Airlines deal was found by Cheapflights users on 11/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/138:15 amDSM - GSP
1 stop6h 29mUnited Airlines
Wed 12/315:36 pmGSP - DSM
1 stop5h 04mUnited Airlines
Deal found 11/27$385
This American Airlines deal was found by Cheapflights users on 11/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/134:05 pmDSM - GSP
1 stop6h 52mAmerican Airlines
Wed 12/315:00 amGSP - DSM
2 stops8h 26mAmerican Airlines
Deal found 11/27$390
This Kiwi.com deal was found by Cheapflights users on 11/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/142:56 pmDSM - GSP
1 stop22h 14mMultiple Airlines
Tue 12/309:33 amGSP - DSM
2 stops23h 08mMultiple Airlines
Deal found 11/27$398
This American Airlines deal was found by Cheapflights users on 11/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/1412:57 pmDSM - GSP
2 stops7h 42mAmerican Airlines
Wed 12/315:00 amGSP - DSM
2 stops8h 26mAmerican Airlines
Deal found 11/27$400
This Kiwi.com deal was found by Cheapflights users on 11/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:56 pmDSM - GSP
1 stop22h 14mMultiple Airlines
Mon 12/298:03 pmGSP - DSM
2 stops36h 38mMultiple Airlines
Deal found 11/27$411
This Kiwi.com deal was found by Cheapflights users on 11/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/112:56 pmDSM - GSP
1 stop22h 14mMultiple Airlines
Thu 1/111:33 amGSP - DSM
2 stops27h 27mMultiple Airlines
Deal found 11/27$421
This American Airlines deal was found by Cheapflights users on 11/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/134:05 pmDSM - GSP
1 stop6h 52mAmerican Airlines
Fri 1/26:00 amGSP - DSM
1 stop5h 49mAmerican Airlines
Deal found 11/27$422
This American Airlines deal was found by Cheapflights users on 11/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1312:15 pmDSM - GSP
2 stops10h 42mAmerican Airlines
Tue 12/308:00 amGSP - DSM
1 stop6h 21mAmerican Airlines
Deal found 11/27$427

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 28, 2025.
Use the filters below to find and compare flights from Des Moines to Greenville that are best for you.

Fly from

Des Moines

Fly to

Greenville

Route

Depart

Return

Price

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 2/21

12:25 pm-5:44 pm

1 stop4h 19m

Greenville

Wed 2/25

5:40 am-10:40 am

1 stop6h 00m

$315

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 1/31

10:15 am-6:14 pm

1 stop6h 59m

Greenville

Wed 2/4

6:50 am-10:41 am

1 stop4h 51m

$317

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 1/7

3:35 pm-8:47 pm

1 stop4h 12m

Greenville

Sun 1/11

6:35 am-10:55 am

1 stop5h 20m

$352

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 1/7

5:35 am-11:08 am

1 stop4h 33m

Greenville

Sun 1/11

7:20 am-11:24 am

1 stop5h 04m

$352

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 1/7

8:35 am-7:50 pm

2 stops10h 15m

Greenville

Sun 1/11

10:45 am-9:20 pm

2 stops11h 35m

$362

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sun 12/14

2:56 pm-2:10 pm

1 stop22h 14m

Greenville

Mon 12/29

8:03 pm-7:41 am

2 stops36h 38m

$375

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 12/11

2:56 pm-2:10 pm

1 stop22h 14m

Greenville

Sun 12/14

4:00 pm-7:03 pm

2 stops28h 03m

$379

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 12/13

3:49 pm-9:45 pm

1 stop4h 56m

Greenville

Thu 1/1

7:37 am-12:26 pm

1 stop5h 49m

$385

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 12/13

8:15 am-3:44 pm

1 stop6h 29m

Greenville

Wed 12/31

5:36 pm-9:40 pm

1 stop5h 04m

$385

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 2/21

10:09 am-8:07 pm

2 stops8h 58m

Greenville

Wed 2/25

8:43 am-1:07 pm

1 stop5h 24m

$390

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/26

Compare providers for flights from Des Moines to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Greenville in November.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Greenville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Greenville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Greenville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Greenville

What is the cheapest month to book a flight from Des Moines to Greenville?

Currently, April is the cheapest month in which you can book a flight from Des Moines to Greenville (average of $216). Flying from Des Moines to Greenville in January is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated November 28, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Des Moines to Greenville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,011 reviews

Crew

8.5

Comfort

7.9

Overall

7.9

Boarding

8.1

Entertainment

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,011 reviews
Delta
7.9
Good
8,011 reviews

Crew

8.5

Comfort

7.9

Overall

7.9

Boarding

8.1

Entertainment

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,044 reviews
Delta
7.9
Good
8,011 reviews

Crew

8.5

Comfort

7.9

Overall

7.9

Boarding

8.1

Entertainment

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Greenville?

    A quick flight from Des Moines to Greenville can take about 4h 12m. Delta provides one of the quickest options available for as low as $352. Airlines will cover a distance of 771 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Des Moines to Greenville round-trip?

    Currently priced at $243, Delta will fly you from Des Moines to Greenville and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on American Airlines for as low as $296. These flights start at 41% lower than the current average price 3 months from now.

  • Can I find deals for flights from Des Moines to Greenville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Greenville.

  • Can I find deals for business class flights from Des Moines to Greenville?

    Yes. Cheapflights offers flight deals from Des Moines to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Greenville?

    Currently, April is the cheapest month in which you can book a flight from Des Moines to Greenville (average of $216). Flying from Des Moines to Greenville in January is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Greenville

See prices for flight routes from nearby airports that may be better suited for you.
Omaha to Charleston flights
Des Moines to Charlotte flights
Omaha to Charlotte flights
Moline to Charlotte flights
Cedar Rapids to Charleston flights
Cedar Rapids to Charlotte flights
Omaha to Savannah flights
Des Moines to Columbia flights
Omaha to Myrtle Beach flights
Des Moines to Charleston flights
Moline to Charleston flights
Cedar Rapids to Savannah flights
Des Moines to Savannah flights
Cedar Rapids to Myrtle Beach flights
Cedar Rapids to Greenville flights
Moline to Savannah flights
Moline to Myrtle Beach flights
Des Moines to Myrtle Beach flights
Cedar Rapids to Columbia flights
Moline to Columbia flights
Moline to Greenville flights
Omaha to Columbia flights
Omaha to Greenville flights
Des Moines to Hilton Head Island flights
Moline to Augusta flights
Moline to Hilton Head Island flights
Waterloo to Charlotte flights
Sioux City to Columbia flights
Sioux City to Charleston flights
Sioux City to Charlotte flights
La Crosse to Greenville flights
La Crosse to Savannah flights
La Crosse to Charlotte flights
Dubuque to Savannah flights
Cedar Rapids to Hilton Head Island flights
Cedar Rapids to Florence flights
Waterloo to Greenville flights
La Crosse to Charleston flights
Omaha to Hilton Head Island flights
Omaha to Florence flights
Moline to Florence flights
Dubuque to Myrtle Beach flights
Dubuque to Greenville flights
Dubuque to Charlotte flights
Waterloo to Myrtle Beach flights

Top 2 airlines flying from Des Moines to Greenville

Discover the top 2 airlines that operate flights from Des Moines to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 28, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$243Average$477FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$296Average$418FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.