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$160+ Cheap flights from Des Moines to Greenville (DSM - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/29. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GSP
Feb 14 — Feb 211
Sat 2/14
Sat 2/21
1 adult, Economy
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Cheap flight deals from Des Moines to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 15, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$330
(American Airlines)

One-way from

$160
(Delta)

Popular in

November

Cheapest in

September

Average price

$386
Provider with most accurate pricing for Des Moines-Greenville flight deals.
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Provider most trusted by Cheapflights users for Des Moines-Greenville flights.
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From Des Moines to Greenville
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One-way flight from Des Moines to Greenville
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Highest demand for flights based on searches. 13% potential increase in price ($62 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($23 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Des Moines to Greenville

Cheapest flights from Des Moines to Greenville
Explore the most affordable flight options available from Des Moines to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 15, 2026.

This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/125:00 am
DSM
-
GSP
1 stop4h 56m
American Airlines
Tue 2/1712:55 pm
GSP
-
DSM
1 stop8h 13m
American Airlines
Deal found 1/14$330
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/265:00 am
DSM
-
GSP
1 stop4h 56m
American Airlines
Mon 3/28:21 pm
GSP
-
DSM
1 stop4h 19m
American Airlines
Deal found 1/14$341
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/2812:30 pm
DSM
-
GSP
1 stop6h 18m
American Airlines
Sat 3/77:29 am
GSP
-
DSM
1 stop6h 36m
American Airlines
Deal found 1/14$342
This American Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:00 am
DSM
-
GSP
2 stops6h 49m
American Airlines
Sat 3/77:02 am
GSP
-
DSM
1 stop7h 15m
American Airlines
Deal found 1/14$346
This Delta deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1812:04 pm
DSM
-
GSP
1 stop5h 33m
Delta
Fri 2/206:49 am
GSP
-
DSM
1 stop5h 12m
Delta
Deal found 1/15$353
This American Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/185:00 am
DSM
-
GSP
2 stops7h 15m
American Airlines
Fri 2/207:02 am
GSP
-
DSM
1 stop7h 15m
American Airlines
Deal found 1/15$358
This Southwest deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:10 am
DSM
-
GSP
2 stops12h 40m
Southwest
Fri 2/208:30 am
GSP
-
DSM
2 stops16h 05m
Southwest
Deal found 1/13$374

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
Use the filters below to find and compare flights from Des Moines to Greenville that are best for you.

Fly from

Des Moines

Fly to

Greenville

Route

Depart

Return

Price

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 2/12

5:00 am-10:56 am

1 stop4h 56m

Greenville

Tue 2/17

12:55 pm-8:08 pm

1 stop8h 13m

$330

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 2/26

5:00 am-10:56 am

1 stop4h 56m

Greenville

Mon 3/2

8:21 pm-11:40 pm

1 stop4h 19m

$341

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Mon 3/2

5:00 am-10:59 am

1 stop4h 59m

Greenville

Sat 3/7

9:03 am-1:17 pm

1 stop5h 14m

$341

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 2/28

12:30 pm-7:48 pm

1 stop6h 18m

Greenville

Sat 3/7

7:29 am-1:05 pm

1 stop6h 36m

$342

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 2/18

3:24 pm-8:41 pm

1 stop4h 17m

Greenville

Fri 2/20

6:30 am-10:53 am

1 stop5h 23m

$353

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 2/18

12:04 pm-6:37 pm

1 stop5h 33m

Greenville

Fri 2/20

6:49 am-11:01 am

1 stop5h 12m

$353

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 2/18

5:00 am-1:15 pm

2 stops7h 15m

Greenville

Fri 2/20

7:02 am-1:17 pm

1 stop7h 15m

$358

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 4/29

7:28 am-3:14 pm

1 stop6h 46m

$160

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 4/29

5:30 am-8:00 pm

2 stops13h 30m

$171

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 5/28

7:00 am-12:12 pm

1 stop4h 12m

$194

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/15

Showing 1-10 of 13 results
1
2

Compare providers for flights from Des Moines to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Greenville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Greenville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Greenville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Greenville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Greenville

What is the cheapest month to book a flight from Des Moines to Greenville?

Currently, April is the cheapest month in which you can book a flight from Des Moines to Greenville (average of $216). Flying from Des Moines to Greenville in January is currently the most expensive (average of $294). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated January 15, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Des Moines to Greenville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,048 reviews

Food

7.2

Entertainment

7.8

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,048 reviews
Delta
7.9
Good
8,048 reviews

Food

7.2

Entertainment

7.8

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,129 reviews
Delta
7.9
Good
8,048 reviews

Food

7.2

Entertainment

7.8

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Greenville?

    A quick flight from Des Moines to Greenville can take about 4h 56m. American Airlines provides one of the quickest options available for as low as $330. Airlines will cover a distance of 771 mi.

  • What are the cheapest airlines flying from Des Moines to Greenville round-trip?

    Currently priced at $243, Delta will fly you from Des Moines to Greenville and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on American Airlines for as low as $296. These flights start at 39% lower than the current average price 3 months from now.

  • Can I find deals for flights from Des Moines to Greenville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Greenville.

  • Can I find deals for business class flights from Des Moines to Greenville?

    Yes. Cheapflights offers flight deals from Des Moines to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Greenville?

    Currently, April is the cheapest month in which you can book a flight from Des Moines to Greenville (average of $216). Flying from Des Moines to Greenville in January is currently the most expensive (average of $294). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

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Top 2 airlines flying from Des Moines to Greenville

Discover the top 2 airlines that operate flights from Des Moines to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$243Average$477FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$296Average$386FlexibilityNo cancel feeOn-time71%

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