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$126+ Cheap flights from Des Moines to Greenville (DSM - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/14. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GSP
Aug 21 — Aug 281
Thu 8/21
Thu 8/28
1 adult, Economy
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Cheap flight deals from Des Moines to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 16, 2025.

Round-trip from

$230
(American Airlines)

One-way from

$126
(Delta)

Popular in

November

Cheapest in

June

Average price

$389
From Des Moines to Greenville
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One-way flight from Des Moines to Greenville
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Highest demand for flights based on searches. 18% potential increase in price ($97 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($26 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Des Moines to Greenville

Cheapest flights from Des Moines to Greenville
Explore the most affordable flight options available from Des Moines to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 16, 2025.

This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/124:09 pmDSM - GSP
1 stop5h 21mAmerican Airlines
Tue 9/167:38 pmGSP - DSM
1 stop4h 28mAmerican Airlines
Deal found 8/13$230
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/305:38 pmDSM - GSP
1 stop4h 20mAmerican Airlines
Tue 10/75:30 pmGSP - DSM
1 stop6h 38mAmerican Airlines
Deal found 8/15$236
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/116:11 pmDSM - GSP
1 stop4h 41mAmerican Airlines
Mon 9/157:38 pmGSP - DSM
1 stop4h 28mAmerican Airlines
Deal found 8/13$237
This American Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/123:50 pmDSM - GSP
1 stop5h 10mAmerican Airlines
Mon 9/157:44 pmGSP - DSM
1 stop5h 01mAmerican Airlines
Deal found 8/13$244
This Southwest deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/126:00 amDSM - GSP
2 stops11h 05mSouthwest
Tue 9/169:30 amGSP - DSM
2 stops13h 50mSouthwest
Deal found 8/13$280
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/308:00 amDSM - GSP
2 stops8h 03mUnited Airlines
Tue 10/79:35 amGSP - DSM
2 stops13h 53mUnited Airlines
Deal found 8/15$317
This American Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/201:24 pmDSM - GSP
1 stop5h 20mAmerican Airlines
Sun 11/235:22 amGSP - DSM
1 stop6h 23mAmerican Airlines
Deal found 8/14$329

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 16, 2025.
Use the filters below to find and compare flights from Des Moines to Greenville that are best for you.

Fly from

Des Moines

Fly to

Greenville

Route

Depart

Return

Price

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Fri 9/12

4:09 pm-10:30 pm

1 stop5h 21m

Greenville

Tue 9/16

7:38 pm-11:06 pm

1 stop4h 28m

$230

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 9/30

5:38 pm-10:58 pm

1 stop4h 20m

Greenville

Tue 10/7

5:30 pm-11:08 pm

1 stop6h 38m

$236

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 9/11

6:11 pm-11:52 pm

1 stop4h 41m

Greenville

Mon 9/15

7:38 pm-11:06 pm

1 stop4h 28m

$237

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Fri 9/12

3:50 pm-10:00 pm

1 stop5h 10m

Greenville

Mon 9/15

7:44 pm-11:45 pm

1 stop5h 01m

$244

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Fri 9/12

6:00 am-6:05 pm

2 stops11h 05m

Greenville

Tue 9/16

9:30 am-10:20 pm

2 stops13h 50m

$280

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sun 8/31

3:45 pm-2:41 pm

1 stop21h 56m

Greenville

Thu 9/4

11:18 am-8:54 am

1 stop22h 36m

$284

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Tue 9/30

8:00 am-5:03 pm

2 stops8h 03m

Greenville

Tue 10/7

9:35 am-10:28 pm

2 stops13h 53m

$317

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 11/20

1:24 pm-7:44 pm

1 stop5h 20m

Greenville

Sun 11/23

5:22 am-10:45 am

1 stop6h 23m

$329

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sun 9/14

5:44 am-1:28 pm

1 stop6h 44m

$126

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sun 9/14

6:11 pm-11:52 pm

1 stop4h 41m

$141

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/15

Showing 1-10 of 11 results
1
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Best time to book a flight from Des Moines to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Greenville

What is the cheapest month to book a flight from Des Moines to Greenville?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Greenville (average of $329). Flying from Des Moines to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to GSP?

Find hourly flight availability from Des Moines to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 16, 2025.

When flying from Des Moines to Greenville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 15% versus a flight in the morning.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated August 16, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Des Moines to Greenville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,985 reviews

Comfort

7.9

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,985 reviews
Delta
8.0
Very good
7,985 reviews

Comfort

7.9

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,985 reviews

Comfort

7.9

Food

7.3

Boarding

8.2

Entertainment

7.9

Overall

8.0

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Des Moines to Greenville round-trip?

    Currently priced at $250, Delta will fly you from Des Moines to Greenville and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on American Airlines for as low as $296. These flights start at 40% lower than the current average price 3 months from now.

  • What are the cheapest airlines to fly from Des Moines to Greenville one-way?

    $126 is the cheapest one-way deal found within the past few days, from Delta. You may also be able to find cheap deals on American Airlines and United Airlines, with prices starting from $141 and $319, respectively.

  • Can I find deals for flights from Des Moines to Greenville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Greenville.

  • Can I find deals for business class flights from Des Moines to Greenville?

    Yes. Cheapflights offers flight deals from Des Moines to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Greenville?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Greenville (average of $329). Flying from Des Moines to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Seneca
Anderson

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Top 2 airlines flying from Des Moines to Greenville

Discover the top 2 airlines that operate flights from Des Moines to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$250Average$463FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$296Average$421FlexibilityNo cancel feeOn-time71%

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