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Greenville

$122+ Cheap flights from Des Moines to Greenville (DSM - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/22. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GSP
jan 17 — jan 241
sáb 1/17
sáb 1/24
1 adult, Economy
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Cheap flight deals from Des Moines to Greenville

Cheapest flights from Des Moines to Greenville
Explore the most affordable flight options available from Des Moines to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on dezembro 18, 2025.

This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 12/2512:53 pmDSM - GSP
1 stop4h 46mAmerican Airlines
seg 1/56:00 amGSP - DSM
1 stop9h 53mAmerican Airlines
Deal found 12/15$328
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qui 12/2511:15 amDSM - GSP
2 stops11h 41mUnited Airlines
seg 1/58:34 amGSP - DSM
1 stop6h 59mUnited Airlines
Deal found 12/15$343
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
qua 12/311:25 pmDSM - GSP
1 stop5h 06mAmerican Airlines
dom 1/48:07 pmGSP - DSM
1 stop13h 08mAmerican Airlines
Deal found 12/15$438
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 12/296:52 pmDSM - GSP
1 stop15h 09mAmerican Airlines
sex 1/26:00 amGSP - DSM
1 stop9h 53mAmerican Airlines
Deal found 12/16$499
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom 12/286:52 pmDSM - GSP
1 stop15h 09mAmerican Airlines
qua 12/318:00 amGSP - DSM
1 stop6h 21mAmerican Airlines
Deal found 12/17$507
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 12/296:52 pmDSM - GSP
1 stop15h 09mAmerican Airlines
sáb 1/37:37 amGSP - DSM
1 stop5h 14mAmerican Airlines
Deal found 12/16$539
This United Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
seg 12/298:00 amDSM - GSP
1 stop25h 56mUnited Airlines
sáb 1/38:34 amGSP - DSM
1 stop6h 59mUnited Airlines
Deal found 12/15$562
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb 12/276:30 amDSM - GSP
1 stop12h 01mAmerican Airlines
ter 12/309:02 amGSP - DSM
1 stop5h 19mAmerican Airlines
Deal found 12/16$587

Find flight deals from Des Moines to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated dezembro 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$293
(Kiwi.com)

One-way from

$122
(Kiwi.com)

Popular in

November

Cheapest in

September

Average price

$446
Provider with most accurate pricing for Des Moines-Greenville flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Greenville flights.
Search Deals
From Des Moines to Greenville
Search Deals
One-way flight from Des Moines to Greenville
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($39 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($21 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated dezembro 18, 2025.
Use the filters below to find and compare flights from Des Moines to Greenville that are best for you.

Fly from

Des Moines

Fly to

Greenville

Route

Depart

Return

Price

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

qui 1/22

2:58 pm-8:58 am

1 stop17h 00m

Greenville

dom 1/25

6:45 pm-10:19 am

2 stops16h 34m

$293

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

qui 1/29

2:58 pm-8:58 am

1 stop17h 00m

Greenville

qui 2/5

5:45 pm-10:19 am

2 stops17h 34m

$305

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

sex 1/23

7:34 am-5:12 pm

1 stop8h 38m

Greenville

seg 1/26

11:30 am-7:34 pm

1 stop9h 04m

$369

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

qui 1/1

3:14 pm-8:47 pm

1 stop4h 33m

Greenville

seg 1/5

6:23 am-2:33 pm

2 stops9h 10m

$373

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

sex 2/27

1:39 pm-11:54 pm

2 stops9h 15m

Greenville

seg 3/2

12:52 pm-8:06 pm

1 stop8h 14m

$374

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

sex 1/23

11:30 am-11:48 pm

2 stops11h 18m

Greenville

seg 1/26

5:34 pm-9:50 pm

1 stop5h 16m

$374

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

qui 1/29

7:43 am-5:09 pm

2 stops8h 26m

Greenville

dom 2/1

7:50 am-11:12 am

1 stop4h 22m

$374

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

qui 1/22

8:00 am-7:29 pm

2 stops10h 29m

Greenville

dom 1/25

10:00 am-9:50 pm

2 stops12h 50m

$379

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

sáb 2/21

3:24 pm-8:41 pm

1 stop4h 17m

Greenville

qua 2/25

10:40 am-2:27 pm

1 stop4h 47m

$384

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

qui 1/22

2:58 pm-8:58 am

1 stop17h 00m

$122

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/16

Showing 1-10 of 17 results
1
2

Compare providers for flights from Des Moines to Greenville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Greenville in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Greenville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Greenville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Greenville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Greenville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Greenville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Greenville

What is the cheapest month to book a flight from Des Moines to Greenville?

Currently, April is the cheapest month in which you can book a flight from Des Moines to Greenville (average of $216). Flying from Des Moines to Greenville in January is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated dezembro 18, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Des Moines to Greenville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,005 reviews

Food

7.3

Comfort

7.9

Boarding

8.1

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,005 reviews
Delta
7.9
Good
8,005 reviews

Food

7.3

Comfort

7.9

Boarding

8.1

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,054 reviews
Delta
7.9
Good
8,005 reviews

Food

7.3

Comfort

7.9

Boarding

8.1

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Greenville?

    A quick flight from Des Moines to Greenville can take about 8h 38m. Delta provides one of the quickest options available for as low as $369. Airlines will cover a distance of 771 mi.

  • What are the cheapest airlines flying from Des Moines to Greenville round-trip?

    Currently priced at $243, Delta will fly you from Des Moines to Greenville and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on American Airlines for as low as $296. These flights start at 42% lower than the current average price 3 months from now.

  • Can I find deals for flights from Des Moines to Greenville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Greenville.

  • Can I find deals for business class flights from Des Moines to Greenville?

    Yes. Cheapflights offers flight deals from Des Moines to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Greenville?

    Currently, April is the cheapest month in which you can book a flight from Des Moines to Greenville (average of $216). Flying from Des Moines to Greenville in January is currently the most expensive (average of $293). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Greer
Seneca
Anderson

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Top 2 airlines flying from Des Moines to Greenville

Discover the top 2 airlines that operate flights from Des Moines to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated dezembro 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$243Average$477FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$296Average$421FlexibilityNo cancel feeOn-time71%

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