HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Greenville

$110+ Cheap flights from Des Moines to Greenville (DSM - GSP)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/25. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GSP
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Greenville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Greenville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Greenville (GSP). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$308
(American Airlines)

One-way from

$110
(American Airlines)

Popular in

November

Cheapest in

June

Average price

$316
From Des Moines to Greenville
Search Deals
One-way flight from Des Moines to Greenville
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($79 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($27 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Des Moines to Greenville

Cheapest flights from Des Moines to Greenville
Explore the most affordable flight options available from Des Moines to Greenville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This American Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/201:06 pmDSM - GSP
1 stop5h 38mAmerican Airlines
Sun 11/236:00 amGSP - DSM
1 stop5h 40mAmerican Airlines
Deal found 9/10$308
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/2611:35 amDSM - GSP
1 stop4h 26mUnited Airlines
Sat 1/38:34 amGSP - DSM
1 stop6h 59mUnited Airlines
Deal found 9/10$317
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/231:51 pmDSM - GSP
1 stop6h 12mAllegiant Air
Sun 10/263:37 pmGSP - DSM
1 stop17h 57mAllegiant Air
Deal found 9/11$352
This Kiwi.com deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/231:51 pmDSM - GSP
1 stop6h 12mMultiple Airlines
Sun 10/2610:33 amGSP - DSM
2 stops29h 17mMultiple Airlines
Deal found 9/11$405
This Delta deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/246:30 pmDSM - GSP
1 stop4h 04mDelta
Sat 9/275:30 amGSP - DSM
1 stop6h 10mDelta
Deal found 9/10$447
This United Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/242:58 pmDSM - GSP
1 stop6h 02mUnited Airlines
Sat 9/276:05 amGSP - DSM
2 stops9h 18mUnited Airlines
Deal found 9/10$452

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Greenville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Des Moines to Greenville that are best for you.

Fly from

Des Moines

Fly to

Greenville

Route

Depart

Return

Price

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 11/20

1:06 pm-7:44 pm

1 stop5h 38m

Greenville

Sun 11/23

6:00 am-10:40 am

1 stop5h 40m

$308

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Fri 12/26

11:35 am-5:01 pm

1 stop4h 26m

Greenville

Sat 1/3

8:34 am-2:33 pm

1 stop6h 59m

$317

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 10/23

1:51 pm-9:03 pm

1 stop6h 12m

Greenville

Sun 10/26

3:37 pm-8:34 am

1 stop17h 57m

$352

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 10/23

1:51 pm-9:03 pm

1 stop6h 12m

Greenville

Sun 10/26

10:33 am-2:50 pm

2 stops29h 17m

$405

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 9/25

7:15 am-2:41 pm

1 stop6h 26m

Greenville

Mon 9/29

6:13 pm-10:37 pm

1 stop5h 24m

$447

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 9/24

6:30 pm-11:34 pm

1 stop4h 04m

Greenville

Sat 9/27

5:30 am-10:40 am

1 stop6h 10m

$447

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Thu 9/25

6:30 am-5:03 pm

2 stops9h 33m

Greenville

Mon 9/29

5:34 pm-9:50 pm

1 stop5h 16m

$452

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Wed 9/24

2:58 pm-10:00 pm

1 stop6h 02m

Greenville

Sat 9/27

6:05 am-2:23 pm

2 stops9h 18m

$452

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 10/25

9:00 am-4:33 pm

1 stop6h 33m

$110

Des MoinesGreenville

DSM - GSP

DSMGSP

Des Moines

Sat 10/25

11:31 am-11:44 pm

2 stops11h 13m

$115

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/11

Showing 1-10 of 16 results
1
2

Best time to book a flight from Des Moines to Greenville

Have a flexible travel schedule? Discover the best time to fly to Greenville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Greenville

What is the cheapest month to book a flight from Des Moines to Greenville?

Currently, August is the cheapest month in which you can book a flight from Des Moines to Greenville (average of $322). Flying from Des Moines to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to GSP?

Find hourly flight availability from Des Moines to Greenville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

When flying from Des Moines to Greenville, the time of day you fly usually plays a role in the price. Save by searching for a flight in the afternoon, which can drop the price by up to 15% versus a flight in the morning.

Reviews of airlines servicing Greenville

Get insights into the airlines that provide service to Greenville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Greenville. Reviews last updated September 11, 2025.
Get a feel of what it's like to fly with Delta and American Airlines from Des Moines to Greenville by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,960 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,960 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Food

7.3

Crew

8.5

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Greenville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Greenville?

    A quick flight from Des Moines to Greenville can take about 4h 26m. American Airlines provides one of the quickest options available for as low as $317. Airlines will cover a distance of 771 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Des Moines to Greenville round-trip?

    Currently priced at $243, Delta will fly you from Des Moines to Greenville and back. In addition to Delta, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on American Airlines for as low as $296. These flights start at 40% lower than the current average price 3 months from now.

  • Can I find deals for flights from Des Moines to Greenville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Greenville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Greenville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Greenville.

  • Can I find deals for business class flights from Des Moines to Greenville?

    Yes. Cheapflights offers flight deals from Des Moines to Greenville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Greenville?

    Currently, August is the cheapest month in which you can book a flight from Des Moines to Greenville (average of $322). Flying from Des Moines to Greenville in March is currently the most expensive (average of $386). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Greenville?

Book flights to Greenville if you plan to visit one of these locations
Simpsonville
Duncan
Seneca
Anderson

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Greenville

See prices for flight routes from nearby airports that may be better suited for you.
Des Moines to Charlotte flights
Omaha to Charlotte flights
Moline to Charlotte flights
Cedar Rapids to Charlotte flights
Omaha to Charleston flights
Des Moines to Charleston flights
Cedar Rapids to Savannah flights
Des Moines to Savannah flights
Cedar Rapids to Charleston flights
Omaha to Savannah flights
Des Moines to Columbia flights
Cedar Rapids to Myrtle Beach flights
Des Moines to Myrtle Beach flights
Moline to Charleston flights
Omaha to Myrtle Beach flights
Moline to Myrtle Beach flights
Omaha to Greenville flights
Moline to Columbia flights
Moline to Savannah flights
Omaha to Columbia flights
Omaha to Hilton Head Island flights
Cedar Rapids to Columbia flights
Moline to Greenville flights
Des Moines to Hilton Head Island flights
Cedar Rapids to Greenville flights
Cedar Rapids to Hilton Head Island flights
La Crosse to Charlotte flights
Sioux City to Charleston flights
Moline to Augusta flights
Moline to Hilton Head Island flights
La Crosse to Savannah flights
Waterloo to Charlotte flights
Waterloo to Myrtle Beach flights
Sioux City to Charlotte flights
La Crosse to Greenville flights
Dubuque to Charlotte flights
Cedar Rapids to Florence flights
La Crosse to Charleston flights
Sioux City to Columbia flights
Omaha to Florence flights
Moline to Florence flights
Dubuque to Savannah flights
Dubuque to Myrtle Beach flights
Dubuque to Greenville flights
Waterloo to Greenville flights

Top 2 airlines flying from Des Moines to Greenville

Discover the top 2 airlines that operate flights from Des Moines to Greenville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$243Average$460FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$296Average$421FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.