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$348+ Cheap flights from Des Moines to Gainesville (DSM - GNV)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/10. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GNV
Jul 22 — Jul 291
Wed 7/22
Wed 7/29
1 adult, Economy
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Cheap flight deals from Des Moines to Gainesville

Cheapest flights from Des Moines to Gainesville
Explore the most affordable flight options available from Des Moines to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 22, 2026.

This American Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/54:13 pm
DSM
-
GNV
1 stop5h 29m
American Airlines
Sat 8/85:19 pm
GNV
-
DSM
1 stop6h 57m
American Airlines
Deal found 6/21$426
This American Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/109:47 am
DSM
-
GNV
1 stop6h 00m
American Airlines
Sat 9/197:33 am
GNV
-
DSM
1 stop5h 31m
American Airlines
Deal found 6/21$429
This Delta deal was found by Cheapflights users on 6/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/55:40 am
DSM
-
GNV
1 stop5h 43m
Delta
Sun 8/96:00 am
GNV
-
DSM
1 stop5h 43m
Delta
Deal found 6/18$458
This American Airlines deal was found by Cheapflights users on 6/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/51:08 pm
DSM
-
GNV
1 stop7h 43m
American Airlines
Sun 8/97:34 pm
GNV
-
DSM
1 stop5h 14m
American Airlines
Deal found 6/19$464
This American Airlines deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/77:04 am
DSM
-
GNV
1 stop5h 16m
American Airlines
Sat 7/117:00 am
GNV
-
DSM
1 stop6h 56m
American Airlines
Deal found 6/22$475
This American Airlines deal was found by Cheapflights users on 6/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/61:08 pm
DSM
-
GNV
1 stop7h 43m
American Airlines
Sun 8/97:34 pm
GNV
-
DSM
1 stop5h 14m
American Airlines
Deal found 6/21$481
This Delta deal was found by Cheapflights users on 6/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:45 am
DSM
-
GNV
1 stop5h 37m
Delta
Sun 11/17:05 pm
GNV
-
DSM
1 stop4h 24m
Delta
Deal found 6/22$503

Find flight deals from Des Moines to Gainesville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Gainesville (GNV). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 22, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$426
(American Airlines)

One-way from

$348
(American Airlines)
Provider with most accurate pricing for Des Moines-Gainesville Regional flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Gainesville Regional flights.
Search Deals
From Des Moines to Gainesville Regional
Search Deals
One-way flight from Des Moines to Gainesville Regional
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 22, 2026.
Use the filters below to find and compare flights from Des Moines to Gainesville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 8/5

4:13 pm-10:42 pm

1 stop5h 29m

Gainesville Regional

Sat 8/8

5:19 pm-11:16 pm

1 stop6h 57m

$426

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 8/5

4:13 pm-10:42 pm

1 stop5h 29m

Gainesville Regional

Sun 8/9

5:45 am-12:49 pm

1 stop8h 04m

$429

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 8/5

5:40 am-12:23 pm

1 stop5h 43m

Gainesville Regional

Sat 8/8

5:35 pm-10:37 pm

1 stop6h 02m

$458

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 8/5

5:40 am-12:23 pm

1 stop5h 43m

Gainesville Regional

Sun 8/9

6:00 am-10:43 am

1 stop5h 43m

$458

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Thu 8/6

1:08 pm-9:51 pm

1 stop7h 43m

Gainesville Regional

Sun 8/9

7:34 pm-11:48 pm

1 stop5h 14m

$481
Quickest round-trip

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Thu 10/29

5:45 am-12:22 pm

1 stop5h 37m

Gainesville Regional

Sun 11/1

7:05 pm-10:29 pm

1 stop4h 24m

$503

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Tue 7/7

6:30 am-6:56 pm

2 stops11h 26m

Gainesville Regional

Sat 7/11

5:21 pm-11:58 pm

1 stop7h 37m

$531

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Thu 9/10

9:47 am-4:47 pm

1 stop6h 00m

Gainesville Regional

Sat 9/19

7:33 am-5:27 pm

2 stops10h 54m

$534
Cheapest one-way
Quickest one-way

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Sat 8/15

4:11 pm-9:28 pm

1 stop4h 17m

$348

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Mon 8/10

4:13 pm-10:42 pm

1 stop5h 29m

$348

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/22

Showing 1-10 of 13 resultsSorted by cheapest first
1
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Compare providers for flights from Des Moines to Gainesville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Gainesville in June.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Gainesville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Gainesville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Gainesville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Gainesville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Gainesville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Gainesville

Have a flexible travel schedule? Discover the best time to fly to Gainesville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Gainesville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Gainesville?

    Airlines like American Airlines fly from Des Moines to Gainesville in about 5h 29m. The time it takes to get you to your destination can typically vary by up to . The distance from Des Moines to Gainesville is about 1036 mi.

  • Can I find deals for flights from Des Moines to Gainesville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Gainesville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Gainesville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Gainesville.

  • Can I find deals for business class flights from Des Moines to Gainesville?

    Yes. Cheapflights offers flight deals from Des Moines to Gainesville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Gainesville?

Book flights to Gainesville if you plan to visit one of these locations
Lake City
Alachua

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Alternative routes for Des Moines to Gainesville

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