$353+ Cheap flights from Des Moines to Gainesville (DSM - GNV)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/26. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GNV
Sep 20 — Sep 271
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Gainesville with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to Gainesville
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Last-minute
One-way
Cheapest flights from Des Moines to GainesvilleExplore the most affordable flight options available from Des Moines to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 21, 2026.
Explore the most affordable flight options available from Des Moines to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 21, 2026.
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/104:14 pm -
1 stop6h 00m
Sat 9/195:18 pm -
1 stop6h 54m
Deal found 8/17![American Airlines logo]()
$387
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:45 am -
1 stop5h 54m
Sat 9/196:05 am -
2 stops9h 01m
Deal found 8/20![Delta logo]()
$392
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:40 am -
1 stop5h 43m
Sat 9/55:35 pm -
1 stop6h 02m
Deal found 8/17![Delta logo]()
$485
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/19:32 am -
2 stops10h 35m
Sat 9/51:53 pm -
2 stops10h 23m
Deal found 8/17![American Airlines logo]()
$502
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/298:03 am -
1 stop6h 55m
Wed 9/307:33 am -
1 stop5h 31m
Deal found 8/20![American Airlines logo]()
$705
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:00 am -
2 stops8h 06m
Wed 9/306:05 am -
1 stop5h 41m
Deal found 8/20![Delta logo]()
$710
Best flights from Des Moines to GainesvilleDiscover carefully curated flight deals from Des Moines to Gainesville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 21, 2026.
Discover carefully curated flight deals from Des Moines to Gainesville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 21, 2026.
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/101:30 pm -
1 stop7h 20m
Sat 9/195:18 pm -
1 stop6h 54m
Deal found 8/20![American Airlines logo]()
$387
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:45 am -
1 stop5h 54m
Sat 9/196:05 am -
2 stops9h 01m
Deal found 8/20![Delta logo]()
$392
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:40 am -
1 stop5h 43m
Sat 9/55:35 pm -
1 stop6h 02m
Deal found 8/17![Delta logo]()
$485
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:00 am -
2 stops8h 06m
Wed 9/306:05 am -
1 stop5h 41m
Deal found 8/20![Delta logo]()
$710
Last-minute flights from Des Moines to GainesvilleDiscover last-minute flight deals from Des Moines to Gainesville. Data last updated August 21, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Gainesville. Data last updated August 21, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:40 am -
1 stop5h 43m
Sat 9/55:35 pm -
1 stop6h 02m
Deal found 8/17![Delta logo]()
$485
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/19:32 am -
2 stops10h 35m
Sat 9/51:53 pm -
2 stops10h 23m
Deal found 8/17![American Airlines logo]()
$502
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/104:14 pm -
1 stop6h 00m
Sat 9/195:18 pm -
1 stop6h 54m
Deal found 8/17![American Airlines logo]()
$387
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:45 am -
1 stop5h 54m
Sat 9/196:05 am -
2 stops9h 01m
Deal found 8/20![Delta logo]()
$392
This American Airlines deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/298:03 am -
1 stop6h 55m
Wed 9/307:33 am -
1 stop5h 31m
Deal found 8/20![American Airlines logo]()
$705
This Delta deal was found by Cheapflights users on 8/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:00 am -
2 stops8h 06m
Wed 9/306:05 am -
1 stop5h 41m
Deal found 8/20![Delta logo]()
$710
One-way flights from Des Moines to GainesvilleSearch for one-way flight options from Des Moines to Gainesville. Find affordable one-way fares based on user searches. Data last updated August 21, 2026.
Search for one-way flight options from Des Moines to Gainesville. Find affordable one-way fares based on user searches. Data last updated August 21, 2026.
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/2611:22 am -
1 stop6h 30m
Deal found 8/17![American Airlines logo]()
$353
This Delta deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/14:11 pm -
1 stop5h 37m
Deal found 8/18![Delta logo]()
$400
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/38:10 am -
1 stop5h 10m
Deal found 8/18![American Airlines logo]()
$403
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/309:32 am -
1 stop6h 15m
Deal found 8/18![American Airlines logo]()
$463
Find flight deals from Des Moines to Gainesville
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Gainesville (GNV). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 21, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $387 (American Airlines) |
One-way from | $353 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 21, 2026.
Use the filters below to find and compare flights from Des Moines to Gainesville that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesGainesville
DSM Des Moines - GNV Gainesville Regional
DSMGNV
Des Moines
Thu 9/10
1:30 pm-9:50 pm
1 stop7h 20m
Gainesville Regional
Sat 9/19
5:18 pm-11:12 pm
1 stop6h 54m
$387
Des MoinesGainesville
DSM Des Moines - GNV Gainesville Regional
DSMGNV
Des Moines
Thu 9/10
5:45 am-12:39 pm
1 stop5h 54m
Gainesville Regional
Sat 9/19
6:05 am-2:06 pm
2 stops9h 01m
$392
Quickest round-trip
Des MoinesGainesville
DSM Des Moines - GNV Gainesville Regional
DSMGNV
Des Moines
Tue 9/1
5:40 am-12:23 pm
1 stop5h 43m
Gainesville Regional
Sat 9/5
5:35 pm-10:37 pm
1 stop6h 02m
$485
Des MoinesGainesville
DSM Des Moines - GNV Gainesville Regional
DSMGNV
Des Moines
Tue 9/29
6:00 am-3:06 pm
2 stops8h 06m
Gainesville Regional
Wed 9/30
6:05 am-10:46 am
1 stop5h 41m
$710
Cheapest one-way
Des MoinesGainesville
DSM Des Moines - GNV Gainesville Regional
DSMGNV
Des Moines
Mon 10/26
11:22 am-6:52 pm
1 stop6h 30m
$353
Quickest one-way
Des MoinesGainesville
DSM Des Moines - GNV Gainesville Regional
DSMGNV
Des Moines
Tue 9/1
4:11 pm-10:48 pm
1 stop5h 37m
$400
Des MoinesGainesville
DSM Des Moines - GNV Gainesville Regional
DSMGNV
Des Moines
Wed 9/2
6:00 am-6:08 pm
2 stops11h 08m
$405
Des MoinesGainesville
DSM Des Moines - GNV Gainesville Regional
DSMGNV
Des Moines
Sun 8/30
9:32 am-4:47 pm
1 stop6h 15m
$463
Sorted by cheapest first
Compare providers for flights from Des Moines to Gainesville
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Gainesville in August.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Gainesville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Gainesville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Gainesville flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Gainesville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Gainesville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Gainesville
Have a flexible travel schedule? Discover the best time to fly to Gainesville from Des Moines with our price prediction graph.
DSM-GNV
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Gainesville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Gainesville?
Book flights to Gainesville if you plan to visit one of these locationsLake City
Alachua
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