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$274+ Cheap flights from Des Moines to Gainesville (DSM - GNV)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/2. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GNV
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Des Moines to Gainesville

Cheapest flights from Des Moines to Gainesville
Explore the most affordable flight options available from Des Moines to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/281:52 pm
DSM
-
GNV
1 stop7h 35m
American Airlines
Tue 3/317:49 am
GNV
-
DSM
1 stop6h 18m
American Airlines
Deal found 1/27$337
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/285:35 am
DSM
-
GNV
1 stop5h 51m
Delta
Sat 1/316:00 am
GNV
-
DSM
1 stop7h 15m
Delta
Deal found 1/27$435
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/305:16 pm
DSM
-
GNV
1 stop4h 13m
Delta
Wed 2/44:59 pm
GNV
-
DSM
1 stop6h 30m
Delta
Deal found 1/26$490
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/3011:42 am
DSM
-
GNV
2 stops11h 15m
American Airlines
Sat 1/316:00 am
GNV
-
DSM
2 stops11h 24m
American Airlines
Deal found 1/26$501
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/111:17 am
DSM
-
GNV
2 stops11h 42m
American Airlines
Wed 3/47:10 am
GNV
-
DSM
1 stop8h 46m
American Airlines
Deal found 1/26$552
This Delta deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/225:15 pm
DSM
-
GNV
1 stop4h 19m
Delta
Thu 2/267:00 pm
GNV
-
DSM
1 stop4h 28m
Delta
Deal found 1/27$557
This Delta deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/15:15 pm
DSM
-
GNV
1 stop4h 19m
Delta
Wed 3/47:00 pm
GNV
-
DSM
1 stop4h 28m
Delta
Deal found 1/26$601

Find flight deals from Des Moines to Gainesville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Gainesville (GNV). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated January 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$337
(American Airlines)

One-way from

$274
(American Airlines)
Provider with most accurate pricing for Des Moines-Gainesville Regional flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Gainesville Regional flights.
Search Deals
From Des Moines to Gainesville Regional
Search Deals
One-way flight from Des Moines to Gainesville Regional
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Des Moines to Gainesville that are best for you.

Fly from

Des Moines

Fly to

Gainesville

Route

Depart

Return

Price

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Sat 3/28

1:52 pm-10:27 pm

1 stop7h 35m

Gainesville Regional

Tue 3/31

7:49 am-1:07 pm

1 stop6h 18m

$337

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Sun 3/1

11:17 am-11:59 pm

2 stops11h 42m

Gainesville Regional

Wed 3/4

7:10 am-2:56 pm

1 stop8h 46m

$552

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Sun 2/22

5:15 pm-10:34 pm

1 stop4h 19m

Gainesville Regional

Thu 2/26

7:00 pm-10:28 pm

1 stop4h 28m

$557

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Sun 3/1

5:15 pm-10:34 pm

1 stop4h 19m

Gainesville Regional

Wed 3/4

7:00 pm-10:28 pm

1 stop4h 28m

$601

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Sun 2/15

6:00 am-5:18 pm

2 stops10h 18m

Gainesville Regional

Wed 2/18

6:00 am-1:18 pm

2 stops8h 18m

$607

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Sun 2/8

4:42 pm-11:30 pm

1 stop5h 48m

Gainesville Regional

Thu 2/12

3:08 pm-9:59 pm

1 stop7h 51m

$627

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Tue 5/26

2:15 pm-10:29 pm

1 stop7h 14m

$274

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Thu 4/2

1:52 pm-10:27 pm

1 stop7h 35m

$274

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Tue 5/26

1:45 pm-11:59 pm

2 stops9h 14m

$279

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Sat 2/14

6:50 am-4:24 pm

2 stops8h 34m

$319

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 15 results
1
2

Compare providers for flights from Des Moines to Gainesville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Gainesville in January.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Gainesville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Gainesville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Gainesville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Gainesville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Gainesville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Gainesville

Have a flexible travel schedule? Discover the best time to fly to Gainesville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Gainesville

What is the cheapest month to book a flight from Des Moines to Gainesville?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Gainesville (average of $42). Flying from Des Moines to Gainesville in December is currently the most expensive (average of $200). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Gainesville

Get insights into the airlines that provide service to Gainesville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Gainesville. Reviews last updated January 28, 2026.
Peruse reviews from past customers who have flown with Delta from Des Moines to Gainesville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,123 reviews

Food

7.2

Entertainment

7.8

Overall

7.9

Crew

8.5

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,123 reviews
Delta
7.9
Good
8,123 reviews

Food

7.2

Entertainment

7.8

Overall

7.9

Crew

8.5

Boarding

8.1

Comfort

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Gainesville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Gainesville?

    Airlines like American Airlines and Delta fly from Des Moines to Gainesville in about 4h 19m. The time it takes to get you to your destination can typically vary by up to 3h 16m. The distance from Des Moines to Gainesville is about 1036 mi. This flight may include one or multiple stops.

  • What is the cheapest airline to fly from Des Moines to Gainesville round-trip?

    Flying on Delta is currently your cheapest option to Gainesville, with prices starting at $253.

  • Can I find deals for flights from Des Moines to Gainesville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Gainesville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Gainesville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Gainesville.

  • Can I find deals for business class flights from Des Moines to Gainesville?

    Yes. Cheapflights offers flight deals from Des Moines to Gainesville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Gainesville?

    Currently, October is the cheapest month in which you can book a flight from Des Moines to Gainesville (average of $42). Flying from Des Moines to Gainesville in December is currently the most expensive (average of $200). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Gainesville?

Book flights to Gainesville if you plan to visit one of these locations
Lake City
Alachua

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Top airline flying from Des Moines to Gainesville

Discover the top airline that operate flights from Des Moines to Gainesville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$253Average$615FlexibilityNo cancel feeOn-timeN/A

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