HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Gainesville

$384+ Cheap flights from Des Moines to Gainesville (DSM - GNV)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/17. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GNV
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Gainesville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Gainesville

Cheapest flights from Des Moines to Gainesville
Explore the most affordable flight options available from Des Moines to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/173:18 pmDSM - GNV
1 stop7h 15mAmerican Airlines
Sat 1/36:30 amGNV - DSM
1 stop7h 44mAmerican Airlines
Deal found 12/16$461
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:07 pmDSM - GNV
1 stop7h 33mAmerican Airlines
Sun 1/48:02 pmGNV - DSM
1 stop5h 35mAmerican Airlines
Deal found 12/16$507
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:07 pmDSM - GNV
1 stop7h 33mAmerican Airlines
Sat 1/36:30 amGNV - DSM
1 stop7h 44mAmerican Airlines
Deal found 12/16$541
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/312:07 pmDSM - GNV
1 stop7h 33mAmerican Airlines
Fri 1/23:27 pmGNV - DSM
2 stops9h 24mAmerican Airlines
Deal found 12/16$566

Find flight deals from Des Moines to Gainesville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Gainesville (GNV). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 18, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$384
(American Airlines)

One-way from

$365
(American Airlines)
Provider with most accurate pricing for Des Moines-Gainesville Regional flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Gainesville Regional flights.
Search Deals
From Des Moines to Gainesville Regional
Search Deals
One-way flight from Des Moines to Gainesville Regional
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Des Moines to Gainesville that are best for you.

Fly from

Des Moines

Fly to

Gainesville

Route

Depart

Return

Price

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Sat 1/17

6:00 am-4:26 pm

2 stops9h 26m

Gainesville Regional

Mon 1/19

4:30 pm-11:23 pm

1 stop7h 53m

$384

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 12/31

2:07 pm-10:40 pm

1 stop7h 33m

Gainesville Regional

Sun 1/4

8:02 pm-12:37 am

1 stop5h 35m

$507

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 12/31

2:07 pm-10:40 pm

1 stop7h 33m

Gainesville Regional

Sat 1/3

6:30 am-1:14 pm

1 stop7h 44m

$541

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 12/31

2:07 pm-10:40 pm

1 stop7h 33m

Gainesville Regional

Fri 1/2

3:27 pm-11:51 pm

2 stops9h 24m

$566

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Thu 1/1

1:15 pm-8:44 pm

1 stop6h 29m

Gainesville Regional

Fri 1/2

6:55 pm-10:31 pm

1 stop4h 36m

$567

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Thu 1/1

1:25 pm-11:59 pm

2 stops9h 34m

Gainesville Regional

Sat 1/3

6:30 am-1:14 pm

1 stop7h 44m

$592

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Thu 1/1

3:28 pm-10:20 pm

1 stop5h 52m

Gainesville Regional

Sun 1/4

8:02 pm-12:37 am

1 stop5h 35m

$607

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/15

Compare providers for flights from Des Moines to Gainesville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Gainesville in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Gainesville flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Gainesville flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Gainesville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Gainesville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Gainesville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Gainesville

Have a flexible travel schedule? Discover the best time to fly to Gainesville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Gainesville

What is the cheapest month to book a flight from Des Moines to Gainesville?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Gainesville (average of $42). Flying from Des Moines to Gainesville in December is currently the most expensive (average of $176). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Gainesville

Get insights into the airlines that provide service to Gainesville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Gainesville. Reviews last updated December 18, 2025.
Peruse reviews from past customers who have flown with Delta from Des Moines to Gainesville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,005 reviews

Overall

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,005 reviews
Delta
7.9
Good
8,005 reviews

Overall

7.9

Boarding

8.1

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Gainesville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Gainesville?

    Airlines like American Airlines fly from Des Moines to Gainesville in about 9h 26m. The time it takes to get you to your destination can typically vary by up to . The distance from Des Moines to Gainesville is about 1036 mi.

  • What is the cheapest airline to fly from Des Moines to Gainesville round-trip?

    Flying on Delta is currently your cheapest option to Gainesville, with prices starting at $253.

  • Can I find deals for flights from Des Moines to Gainesville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Gainesville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Gainesville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Gainesville.

  • Can I find deals for business class flights from Des Moines to Gainesville?

    Yes. Cheapflights offers flight deals from Des Moines to Gainesville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Gainesville?

    Currently, October is the cheapest month in which you can book a flight from Des Moines to Gainesville (average of $42). Flying from Des Moines to Gainesville in December is currently the most expensive (average of $176). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Gainesville?

Book flights to Gainesville if you plan to visit one of these locations
Lake City
Alachua

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Gainesville

See prices for flight routes from nearby airports that may be better suited for you.
Omaha to Orlando flights
Cedar Rapids to Orlando flights
Des Moines to Orlando flights
Omaha to Miami flights
Des Moines to Miami flights
Moline to Tampa flights
Cedar Rapids to Tampa flights
Cedar Rapids to Fort Myers flights
Des Moines to Tampa flights
Cedar Rapids to Miami flights
Moline to Orlando flights
Omaha to Tampa flights
Moline to Fort Myers flights
Des Moines to Pensacola flights
Cedar Rapids to Fort Lauderdale flights
Omaha to Fort Lauderdale flights
Moline to Miami flights
Des Moines to Sarasota flights
Des Moines to Fort Myers flights
Cedar Rapids to Orlando Sanford Intl flights
Des Moines to Fort Lauderdale flights
Des Moines to Orlando Sanford Intl flights
Moline to Fort Lauderdale flights
Moline to Sarasota flights
Omaha to Key West flights
Omaha to Pensacola flights
Cedar Rapids to Key West flights
Moline to Pensacola flights
Des Moines to Key West flights
Cedar Rapids to St Petersburg flights
Omaha to Jacksonville flights
Cedar Rapids to Punta Gorda flights
Des Moines to Valparaiso flights
Cedar Rapids to Pensacola flights
Des Moines to St Petersburg flights
Cedar Rapids to Sarasota flights
Omaha to Panama City flights
Omaha to Fort Myers flights
Omaha to Sarasota flights
Omaha to Valparaiso flights
Cedar Rapids to Jacksonville flights
Des Moines to West Palm Beach flights
Des Moines to Panama City flights
Moline to Key West flights
Des Moines to Punta Gorda flights
Omaha to West Palm Beach flights
Moline to St Petersburg flights
Des Moines to Jacksonville flights
Cedar Rapids to West Palm Beach flights
Omaha to Melbourne flights

Top airline flying from Des Moines to Gainesville

Discover the top airline that operate flights from Des Moines to Gainesville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$336Average$561FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.