What is the cheapest airline to fly from Des Moines to Gainesville round-trip?

Flying on Delta is currently your cheapest option to Gainesville, with prices starting at $422. Delta is priced at 25% lower than the current average price of a flight leaving 3 months from now.

What is the cheapest day to fly from Des Moines to Gainesville?

Travelers seeking maximum savings on their Des Moines to Gainesville flight should consider departing on Tuesday at noon when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

In terms of precipitation, rainfall in Gainesville ranges from 2.1 - 7.1 inches per month. June is typically the wettest month, when rainfall can reach 7.1 in. November is typically the driest time to visit Gainesville when rainfall is around 2.1 in.

If weather is an important factor for your trip to Gainesville, use this chart to help with planning. For those seeking warmer temperatures, June is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 53.6 F).

What is the cheapest day to fly round-trip from Des Moines to Gainesville?

It’s generally more expensive to depart on a Tuesday, if you have to leave on this day you can still search on Cheapflights to find great options that meet your needs.

What is the cheapest month to fly from Des Moines to Gainesville?

July can be a great time to fly to Gainesville from Des Moines with a flight ticket averaging about $568. Cheapflights users have found deals in the month of July for as cheap as $94. The most expensive prices can be found in the month of February.

What is the cheapest time of day to fly from DSM to GNV?

It’s typically best to fly out from Des Moines to Gainesville at noon. Doing so could potentially save you 41% on the flight price compared to flying in the morning, which is usually more expensive.

Can I find deals for flights from Des Moines to Gainesville that include hotel bookings?

Yes. In addition to deals on Des Moines to Gainesville flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Gainesville?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Gainesville.

Can I find deals for business class flights from Des Moines to Gainesville?

Yes. Cheapflights offers flight deals from Des Moines to Gainesville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$407+ Cheap Flights from Des Moines to Gainesville

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Cheap flight deals from Des Moines to Gainesville

Round-trip from	$407 (American Airlines)
Popular in	February
Cheapest in	July
Average price	$778

From Des Moines to Gainesville Regional

Search Deals

Highest demand for flights based on searches. 31% potential increase in price ($260 potential increase over avg. RT price).

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Cheapest flight prices on average. 5% potential price decrease ($29 potential savings vs. average RT price).

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Average for round-trip flights in August 2025

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Find flight deals from Des Moines to Gainesville

Cheapest flights from Des Moines to Gainesville
Explore the most affordable flight options available from Des Moines to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on août 14, 2025.

ven. 9/124:09 pmDSM - GNV

1 stop5h 27mAmerican Airlines

ven. 9/194:43 pmGNV - DSM

1 stop7h 23mAmerican Airlines

Deal found 8/13

$407

Best flights from Des Moines to Gainesville
Discover carefully curated flight deals from Des Moines to Gainesville that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated août 14, 2025.

ven. 9/124:09 pmDSM - GNV

1 stop5h 27mAmerican Airlines

ven. 9/194:43 pmGNV - DSM

1 stop7h 23mAmerican Airlines

Deal found 8/13

$407

Last-minute flights from Des Moines to Gainesville
Discover last-minute flight deals from Des Moines to Gainesville. Data last updated août 14, 2025 and is based on user searches.

ven. 9/124:09 pmDSM - GNV

1 stop5h 27mAmerican Airlines

ven. 9/194:43 pmGNV - DSM

1 stop7h 23mAmerican Airlines

Deal found 8/13

$407

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Gainesville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

ven. 9/12

4:09 pm-10:36 pm

1 stop5h 27m

Gainesville Regional

ven. 9/19

4:43 pm-11:06 pm

1 stop7h 23m

$407

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/13

Best time to book a flight from Des Moines to Gainesville

Have a flexible travel schedule? Discover the best time to fly to Gainesville from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Gainesville

What is the cheapest month to book a flight from Des Moines to Gainesville?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Gainesville (average of $359). Flying from Des Moines to Gainesville in November is currently the most expensive (average of $510). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Gainesville

Peruse reviews from past customers who have flown with Delta from Des Moines to Gainesville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,980 reviews

Delta

8.0

Very good

7,980 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

What is the cheapest airline to fly from Des Moines to Gainesville round-trip?
Flying on Delta is currently your cheapest option to Gainesville, with prices starting at $422. Delta is priced at 25% lower than the current average price of a flight leaving 3 months from now.
Can I find deals for flights from Des Moines to Gainesville that include hotel bookings?
Yes. In addition to deals on Des Moines to Gainesville flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Gainesville?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Gainesville.
Can I find deals for business class flights from Des Moines to Gainesville?
Yes. Cheapflights offers flight deals from Des Moines to Gainesville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Gainesville?
Currently, January is the cheapest month in which you can book a flight from Des Moines to Gainesville (average of $359). Flying from Des Moines to Gainesville in November is currently the most expensive (average of $510). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Lake City

Alachua

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Top airline flying from Des Moines to Gainesville

Airline	Cheapest	Average	Flexibility	On-time
Delta	Cheapest$422	Average$561	FlexibilityNo cancel fee	On-timeN/A

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$407+ Cheap flights from Des Moines to Gainesville (DSM - GNV)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/12. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Gainesville with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Des Moines to Gainesville

Round-trip from

Popular in

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Average price

Find flight deals from Des Moines to Gainesville

Cheapest flights from Des Moines to GainesvilleExplore the most affordable flight options available from Des Moines to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on août 14, 2025.

Explore the most affordable flight options available from Des Moines to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on août 14, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Gainesville that are best for you.

Best time to book a flight from Des Moines to Gainesville

Have a flexible travel schedule? Discover the best time to fly to Gainesville from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Gainesville

What is the cheapest month to book a flight from Des Moines to Gainesville?

Reviews of airlines servicing Gainesville

Peruse reviews from past customers who have flown with Delta from Des Moines to Gainesville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Gainesville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What is the cheapest airline to fly from Des Moines to Gainesville round-trip?

Can I find deals for flights from Des Moines to Gainesville that include hotel bookings?

How can I find direct flights from Des Moines to Gainesville?

Can I find deals for business class flights from Des Moines to Gainesville?

What is the cheapest month to book a flight from Des Moines to Gainesville?

Traveling to a place near Gainesville?

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Alternative routes for Des Moines to Gainesville

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Top airline flying from Des Moines to Gainesville

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Cheapest flights from Des Moines to Gainesville
Explore the most affordable flight options available from Des Moines to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on août 14, 2025.