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$264+ Cheap flights from Des Moines to Gainesville (DSM - GNV)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/6. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GNV
oct. 17 — oct. 241
vie. 10/17
vie. 10/24
1 adult, Economy
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Cheap flight deals from Des Moines to Gainesville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Gainesville (GNV). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated septiembre 17, 2025.

Round-trip from

$447
(American Airlines)

One-way from

$264
(American Airlines)
From Des Moines to Gainesville Regional
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One-way flight from Des Moines to Gainesville Regional
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Find flight deals from Des Moines to Gainesville

Cheapest flights from Des Moines to Gainesville
Explore the most affordable flight options available from Des Moines to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on septiembre 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/66:22 pmDSM - GNV
1 stop4h 55mAmerican Airlines
lun. 10/131:46 pmGNV - DSM
1 stop4h 56mAmerican Airlines
Deal found 9/15$447
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/26:11 pmDSM - GNV
1 stop5h 02mAmerican Airlines
lun. 10/64:46 pmGNV - DSM
1 stop6h 42mAmerican Airlines
Deal found 9/17$545
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/65:47 amDSM - GNV
1 stop6h 00mDelta
vie. 10/107:07 pmGNV - DSM
1 stop4h 23mDelta
Deal found 9/17$567
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 10/65:30 amDSM - GNV
1 stop6h 46mAmerican Airlines
vie. 10/106:00 amGNV - DSM
2 stops10h 03mAmerican Airlines
Deal found 9/17$572
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/236:37 pmDSM - GNV
1 stop4h 16mDelta
dom. 12/286:00 amGNV - DSM
1 stop5h 39mDelta
Deal found 9/16$592

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
Use the filters below to find and compare flights from Des Moines to Gainesville that are best for you.

Fly from

Des Moines

Fly to

Gainesville

Route

Depart

Return

Price

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

lun. 10/6

6:22 pm-12:17 am

1 stop4h 55m

Gainesville Regional

lun. 10/13

1:46 pm-5:42 pm

1 stop4h 56m

$447

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

jue. 10/2

6:11 pm-12:13 am

1 stop5h 02m

Gainesville Regional

lun. 10/6

4:46 pm-10:28 pm

1 stop6h 42m

$545

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

lun. 10/6

5:47 am-12:47 pm

1 stop6h 00m

Gainesville Regional

vie. 10/10

7:07 pm-10:30 pm

1 stop4h 23m

$567

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

lun. 10/6

3:48 pm-10:27 pm

1 stop5h 39m

Gainesville Regional

vie. 10/10

6:00 am-3:03 pm

2 stops10h 03m

$572

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

mar. 12/23

6:37 pm-11:53 pm

1 stop4h 16m

Gainesville Regional

dom. 12/28

6:00 am-10:39 am

1 stop5h 39m

$592

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

jue. 11/6

2:16 pm-10:26 pm

1 stop7h 10m

$264

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

vie. 11/7

3:39 pm-10:37 pm

1 stop5h 58m

$264

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

mar. 12/23

6:37 pm-11:53 pm

1 stop4h 16m

$329

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Best time to book a flight from Des Moines to Gainesville

Have a flexible travel schedule? Discover the best time to fly to Gainesville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Gainesville

What is the cheapest month to book a flight from Des Moines to Gainesville?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Gainesville (average of $359). Flying from Des Moines to Gainesville in November is currently the most expensive (average of $513). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Gainesville

Get insights into the airlines that provide service to Gainesville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Gainesville. Reviews last updated septiembre 17, 2025.
Peruse reviews from past customers who have flown with Delta from Des Moines to Gainesville to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Entertainment

7.9

Food

7.3

Comfort

7.9

Overall

8.0

Boarding

8.2

Crew

8.5

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Gainesville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Gainesville?

    Airlines like American Airlines fly from Des Moines to Gainesville in about 4h 55m. The time it takes to get you to your destination can typically vary by up to . The distance from Des Moines to Gainesville is about 1036 mi.

  • What is the cheapest airline to fly from Des Moines to Gainesville round-trip?

    Flying on Delta is currently your cheapest option to Gainesville, with prices starting at $422.

  • Can I find deals for flights from Des Moines to Gainesville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Gainesville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Gainesville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Gainesville.

  • Can I find deals for business class flights from Des Moines to Gainesville?

    Yes. Cheapflights offers flight deals from Des Moines to Gainesville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Gainesville?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Gainesville (average of $359). Flying from Des Moines to Gainesville in November is currently the most expensive (average of $513). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Gainesville?

Book flights to Gainesville if you plan to visit one of these locations
Lake City
Alachua

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Alternative routes for Des Moines to Gainesville

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Top airline flying from Des Moines to Gainesville

Discover the top airline that operate flights from Des Moines to Gainesville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated septiembre 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$422Average$561FlexibilityNo cancel feeOn-timeN/A

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