HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Gainesville

$348+ Cheap flights from Des Moines to Gainesville (DSM - GNV)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/16. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — GNV
May 6 — May 131
Wed 5/6
Wed 5/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Gainesville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Des Moines to Gainesville

Cheapest flights from Des Moines to Gainesville
Explore the most affordable flight options available from Des Moines to Gainesville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 6, 2026.

This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/107:05 am
DSM
-
GNV
1 stop4h 56m
American Airlines
Sat 9/195:54 pm
GNV
-
DSM
1 stop7h 21m
American Airlines
Deal found 4/1$419
This Delta deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/105:45 am
DSM
-
GNV
1 stop5h 37m
Delta
Sat 9/196:00 am
GNV
-
DSM
1 stop5h 14m
Delta
Deal found 4/5$458
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:00 am
DSM
-
GNV
2 stops10h 17m
American Airlines
Tue 5/56:25 am
GNV
-
DSM
2 stops11h 06m
American Airlines
Deal found 4/2$491
This American Airlines deal was found by Cheapflights users on 4/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/173:00 pm
DSM
-
GNV
1 stop6h 19m
American Airlines
Tue 4/215:14 pm
GNV
-
DSM
1 stop7h 02m
American Airlines
Deal found 4/2$521
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/1612:06 pm
DSM
-
GNV
2 stops10h 53m
American Airlines
Sat 4/183:07 pm
GNV
-
DSM
1 stop7h 20m
American Airlines
Deal found 4/1$526
This Delta deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/172:44 pm
DSM
-
GNV
1 stop6h 55m
Delta
Fri 4/247:03 pm
GNV
-
DSM
1 stop4h 31m
Delta
Deal found 4/1$527
This American Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/306:00 am
DSM
-
GNV
2 stops10h 17m
American Airlines
Sun 5/107:05 am
GNV
-
DSM
1 stop8h 42m
American Airlines
Deal found 4/3$528
This American Airlines deal was found by Cheapflights users on 4/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1712:06 pm
DSM
-
GNV
2 stops9h 13m
American Airlines
Fri 4/245:47 pm
GNV
-
DSM
1 stop5h 31m
American Airlines
Deal found 4/1$532

Find flight deals from Des Moines to Gainesville

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Gainesville (GNV). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 6, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$419
(American Airlines)

One-way from

$348
(American Airlines)
Provider with most accurate pricing for Des Moines-Gainesville Regional flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Gainesville Regional flights.
Search Deals
From Des Moines to Gainesville Regional
Search Deals
One-way flight from Des Moines to Gainesville Regional
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Gainesville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 6, 2026.
Use the filters below to find and compare flights from Des Moines to Gainesville that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Thu 9/10

7:05 am-1:01 pm

1 stop4h 56m

Gainesville Regional

Sat 9/19

5:54 pm-12:15 am

1 stop7h 21m

$419
Quickest round-trip

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Thu 9/10

5:45 am-12:22 pm

1 stop5h 37m

Gainesville Regional

Sat 9/19

6:00 am-10:14 am

1 stop5h 14m

$458

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Thu 4/30

6:00 am-5:17 pm

2 stops10h 17m

Gainesville Regional

Tue 5/5

5:14 pm-11:16 pm

1 stop7h 02m

$521
Cheapest one-way
Quickest one-way

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 9/16

5:45 am-12:22 pm

1 stop5h 37m

$348

Des MoinesGainesville

DSM - GNV

DSMGNV

Des Moines

Wed 9/16

5:00 am-1:01 pm

2 stops7h 01m

$353

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/1

Sorted by cheapest first

Compare providers for flights from Des Moines to Gainesville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Gainesville in April.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Gainesville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Gainesville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Gainesville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Gainesville flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Gainesville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Gainesville

Have a flexible travel schedule? Discover the best time to fly to Gainesville from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Gainesville

What is the cheapest month to book a flight from Des Moines to Gainesville?

Currently, October is the cheapest month in which you can book a flight from Des Moines to Gainesville (average of $42). Flying from Des Moines to Gainesville in April is currently the most expensive (average of $216). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Gainesville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Des Moines to Gainesville?

    Airlines like American Airlines fly from Des Moines to Gainesville in about 4h 56m. The time it takes to get you to your destination can typically vary by up to . The distance from Des Moines to Gainesville is about 1036 mi.

  • Can I find deals for flights from Des Moines to Gainesville that include hotel bookings?

    Yes. In addition to deals on Des Moines to Gainesville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Gainesville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Gainesville.

  • Can I find deals for business class flights from Des Moines to Gainesville?

    Yes. Cheapflights offers flight deals from Des Moines to Gainesville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Gainesville?

    Currently, October is the cheapest month in which you can book a flight from Des Moines to Gainesville (average of $42). Flying from Des Moines to Gainesville in April is currently the most expensive (average of $216). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Gainesville?

Book flights to Gainesville if you plan to visit one of these locations
Lake City
Alachua

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Gainesville

See prices for flight routes from nearby airports that may be better suited for you.
Omaha to Orlando flights
Cedar Rapids to Orlando flights
Des Moines to Orlando flights
Omaha to Miami flights
Moline to Orlando flights
Cedar Rapids to Fort Myers flights
Omaha to Tampa flights
Des Moines to Miami flights
Moline to Tampa flights
Cedar Rapids to Tampa flights
Omaha to Fort Lauderdale flights
Des Moines to Key West flights
Des Moines to Fort Lauderdale flights
Des Moines to Sarasota flights
Des Moines to Fort Myers flights
Omaha to Sarasota flights
Moline to Fort Myers flights
Des Moines to Jacksonville flights
Cedar Rapids to Sarasota flights
Des Moines to Tampa flights
Cedar Rapids to Panama City flights
Des Moines to Pensacola flights
Cedar Rapids to Pensacola flights
Moline to Miami flights
Cedar Rapids to Jacksonville flights
Moline to Sarasota flights
Omaha to Panama City flights
Cedar Rapids to St Petersburg flights
Moline to Pensacola flights
Moline to St Petersburg flights
Cedar Rapids to Orlando Sanford Intl flights
Omaha to Pensacola flights
Omaha to Orlando Sanford Intl flights
Des Moines to Panama City flights
Cedar Rapids to Fort Lauderdale flights
Cedar Rapids to Punta Gorda flights
Omaha to Fort Myers flights
Cedar Rapids to Miami flights
Omaha to St Petersburg flights
Des Moines to St Petersburg flights
Des Moines to Orlando Sanford Intl flights
La Crosse to Orlando flights
Cedar Rapids to Key West flights
Moline to Panama City flights
Des Moines to West Palm Beach flights
Omaha to Jacksonville flights
Moline to Key West flights
Moline to Daytona Beach flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.