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$435+ Cheap flights from Mississippi to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/22. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — FLO
Nov 29 — Dec 61
Sat 11/29
Sat 12/6
1 adult, Economy
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Find flight deals from Mississippi to Florence

Cheapest flights from Mississippi to Florence
Explore the most affordable flight options available from Mississippi to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.

This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:00 amMEM - FLO
1 stop6h 26mAmerican Airlines
Sun 1/45:15 amFLO - MEM
1 stop4h 32mAmerican Airlines
Deal found 10/30$435
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:10 amJAN - FLO
1 stop6h 16mAmerican Airlines
Fri 1/26:30 pmFLO - JAN
1 stop6h 42mAmerican Airlines
Deal found 10/30$435
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:00 amJAN - FLO
1 stop4h 45mAmerican Airlines
Mon 11/1710:29 amFLO - JAN
1 stop5h 41mAmerican Airlines
Deal found 10/29$517
This American Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:27 pmBTR - FLO
1 stop5h 36mAmerican Airlines
Mon 11/1710:29 amFLO - BTR
1 stop4h 21mAmerican Airlines
Deal found 10/29$543
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:00 amMEM - FLO
1 stop6h 26mAmerican Airlines
Fri 1/21:07 pmFLO - MEM
2 stops12h 07mAmerican Airlines
Deal found 10/30$569
This American Airlines deal was found by Cheapflights users on 10/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/91:00 pmBTR - FLO
1 stop4h 07mAmerican Airlines
Mon 11/1010:29 amFLO - BTR
1 stop7h 22mAmerican Airlines
Deal found 10/30$833

Cheap flight deals from Mississippi to Florence

Keep the following information in mind while searching for Mississippi to Florence flight deals. Data was last updated October 30, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$435
(American Airlines)
Provider with most accurate pricing for Jackson-Evers Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Jackson-Evers Intl-Florence flights.
Search Deals
From Mississippi to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Mississippi to Florence that are best for you.

Fly from

Mississippi

Fly to

Florence

Route

Depart

Return

Price

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Mon 12/22

7:05 am-12:26 pm

1 stop4h 21m

Florence

Sun 1/4

6:30 pm-11:56 pm

1 stop6h 26m

$435

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Mon 12/22

7:05 am-12:26 pm

1 stop4h 21m

Florence

Fri 1/2

6:30 pm-11:56 pm

1 stop6h 26m

$435

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Mon 12/22

5:10 am-12:26 pm

1 stop6h 16m

Florence

Fri 1/2

6:30 pm-12:12 am

1 stop6h 42m

$435

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Thu 11/13

5:00 am-10:45 am

1 stop4h 45m

Florence

Mon 11/17

10:29 am-3:10 pm

1 stop5h 41m

$517

Baton RougeFlorence

BTR - FLO

BTRFLO

Baton Rouge Ryan

Thu 11/13

5:27 pm-12:03 am

1 stop5h 36m

Florence

Mon 11/17

10:29 am-1:50 pm

1 stop4h 21m

$543

Baton RougeFlorence

BTR - FLO

BTRFLO

Baton Rouge Ryan

Sun 11/9

1:00 pm-6:07 pm

1 stop4h 07m

Florence

Mon 11/10

10:29 am-4:51 pm

1 stop7h 22m

$833

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/29

Best time to book a flight from Mississippi to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Florence

What is the cheapest month to book a flight from Mississippi to Florence, South Carolina?

Currently, August is the cheapest month in which you can book a flight from Mississippi to Florence, South Carolina (average of $191). Flying from Mississippi to Florence, South Carolina in March is currently the most expensive (average of $320). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Mississippi?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly into when you book flights from Mississippi to Florence.

  • How long is the flight from Mississippi to Florence, South Carolina?

    American Airlines can get you from Mississippi to Florence, South Carolina in just under 4h 21m. Your travel time can differ by up to . The distance between Mississippi and Florence, South Carolina is about 586 mi.

  • What are the most popular routes from Mississippi to Florence, South Carolina?

    The most popular flight routes from Mississippi to Florence, South Carolina are Memphis - Florence, Jackson-Evers Intl - Florence and Baton Rouge Ryan - Florence.

  • Can I find deals for flights from Mississippi to Florence that include hotel bookings?

    Yes. In addition to deals on Mississippi to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Florence.

  • Can I find deals for business class flights from Mississippi to Florence?

    Yes. Cheapflights offers flight deals from Mississippi to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Florence, South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Mississippi to Florence, South Carolina (average of $191). Flying from Mississippi to Florence, South Carolina in March is currently the most expensive (average of $320). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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