HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$471+ Cheap flights from Mississippi to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/22. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — FLO
Apr 22 — Apr 291
Wed 4/22
Wed 4/29
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Mississippi to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Mississippi to Florence

Cheapest flights from Mississippi to Florence
Explore the most affordable flight options available from Mississippi to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 23, 2026.

This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/222:56 pm
MEM
-
FLO
1 stop6h 04m
American Airlines
Tue 5/265:05 am
FLO
-
MEM
1 stop6h 02m
American Airlines
Deal found 3/20$471
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/214:31 pm
BTR
-
FLO
1 stop6h 26m
American Airlines
Mon 3/236:20 pm
FLO
-
BTR
1 stop4h 16m
American Airlines
Deal found 3/20$566
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:08 pm
MEM
-
FLO
1 stop4h 49m
American Airlines
Tue 4/74:02 pm
FLO
-
MEM
1 stop3h 59m
American Airlines
Deal found 3/19$627
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:08 pm
MEM
-
FLO
1 stop4h 49m
American Airlines
Wed 4/84:16 pm
FLO
-
MEM
2 stops8h 26m
American Airlines
Deal found 3/19$632
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:08 pm
MEM
-
FLO
1 stop4h 49m
American Airlines
Tue 4/76:15 am
FLO
-
MEM
1 stop3h 59m
American Airlines
Deal found 3/19$651
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:08 pm
MEM
-
FLO
1 stop4h 49m
American Airlines
Wed 4/84:16 pm
FLO
-
MEM
2 stops8h 26m
American Airlines
Deal found 3/19$656
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:08 pm
MEM
-
FLO
1 stop4h 49m
American Airlines
Mon 4/66:20 pm
FLO
-
MEM
1 stop6h 31m
American Airlines
Deal found 3/19$667
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:08 pm
MEM
-
FLO
1 stop4h 49m
American Airlines
Thu 4/94:16 pm
FLO
-
MEM
2 stops8h 26m
American Airlines
Deal found 3/19$672
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:08 pm
MEM
-
FLO
1 stop4h 49m
American Airlines
Thu 4/95:20 am
FLO
-
MEM
1 stop3h 58m
American Airlines
Deal found 3/19$691
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/26:08 pm
MEM
-
FLO
1 stop4h 49m
American Airlines
Fri 4/104:16 pm
FLO
-
MEM
2 stops8h 26m
American Airlines
Deal found 3/19$696
This American Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/191:58 pm
JAN
-
FLO
1 stop6h 49m
American Airlines
Sun 4/265:20 am
FLO
-
JAN
1 stop19h 39m
American Airlines
Deal found 3/22$726
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/45:30 am
JAN
-
FLO
2 stops17h 27m
American Airlines
Wed 4/85:20 am
FLO
-
JAN
2 stops15h 12m
American Airlines
Deal found 3/20$829

Find flight deals from Mississippi to Florence

Keep the following information in mind while searching for Mississippi to Florence flight deals. Data was last updated March 23, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$471
(American Airlines)
Provider with most accurate pricing for Jackson-Evers Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Jackson-Evers Intl-Florence flights.
Search Deals
From Mississippi to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 23, 2026.
Use the filters below to find and compare flights from Mississippi to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Fri 4/3

6:08 pm-11:57 pm

1 stop4h 49m

Florence

Tue 4/7

4:02 pm-7:01 pm

1 stop3h 59m

$627

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Thu 4/2

6:08 pm-11:57 pm

1 stop4h 49m

Florence

Wed 4/8

4:16 pm-11:42 pm

2 stops8h 26m

$656

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Thu 4/2

6:08 pm-11:57 pm

1 stop4h 49m

Florence

Thu 4/9

4:16 pm-11:42 pm

2 stops8h 26m

$696

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Sun 4/19

1:58 pm-9:47 pm

1 stop6h 49m

Florence

Sun 4/26

5:20 am-11:59 pm

1 stop19h 39m

$726

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Sat 4/4

5:30 am-11:57 pm

2 stops17h 27m

Florence

Wed 4/8

5:20 am-7:32 pm

2 stops15h 12m

$829

MobileFlorence

MOB - FLO

MOBFLO

Mobile

Mon 4/6

10:41 am-5:50 pm

1 stop6h 09m

Florence

Fri 4/10

5:20 am-10:14 am

1 stop5h 54m

$833

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Thu 4/2

5:04 am-11:57 pm

2 stops17h 53m

Florence

Tue 4/7

4:02 pm-11:42 pm

2 stops8h 40m

$844

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Thu 4/2

5:04 am-11:57 pm

2 stops17h 53m

Florence

Fri 4/10

4:16 pm-11:42 pm

2 stops8h 26m

$862

Baton RougeFlorence

BTR - FLO

BTRFLO

Baton Rouge Ryan

Sun 4/5

4:39 pm-11:57 pm

1 stop6h 18m

Florence

Thu 4/9

4:16 pm-9:25 pm

1 stop6h 09m

$893

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/19

Sorted by cheapest first

Best time to book a flight from Mississippi to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Florence

What is the cheapest month to book a flight from Mississippi to Florence, South Carolina?

Currently, August is the cheapest month in which you can book a flight from Mississippi to Florence, South Carolina (average of $191). Flying from Mississippi to Florence, South Carolina in December is currently the most expensive (average of $388). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Mississippi?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly into when you book flights from Mississippi to Florence.

  • How long is the flight from Mississippi to Florence, South Carolina?

    American Airlines can get you from Mississippi to Florence, South Carolina in just under 4h 49m. Your travel time can differ by up to . The distance between Mississippi and Florence, South Carolina is about 586 mi.

  • What are the most popular routes from Mississippi to Florence, South Carolina?

    The most popular flight routes from Mississippi to Florence, South Carolina are Baton Rouge Ryan - Florence, Memphis - Florence and Mobile - Florence.

  • Can I find deals for flights from Mississippi to Florence that include hotel bookings?

    Yes. In addition to deals on Mississippi to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Florence.

  • Can I find deals for business class flights from Mississippi to Florence?

    Yes. Cheapflights offers flight deals from Mississippi to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Florence, South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Mississippi to Florence, South Carolina (average of $191). Flying from Mississippi to Florence, South Carolina in December is currently the most expensive (average of $388). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Mississippi to Florence

See prices for flight routes from nearby airports that may be better suited for you.
LaGuardia to Charleston flights
Boston to Charleston flights
John F Kennedy Intl to Charlotte flights
John F Kennedy Intl to Charleston flights
LaGuardia to Charlotte flights
Newark to Charleston flights
Newark to Charlotte flights
Boston to Savannah flights
O'Hare Intl to Charlotte flights
Newark to Savannah flights
John F Kennedy Intl to Savannah flights
O'Hare Intl to Charleston flights
O'Hare Intl to Savannah flights
Boston to Charlotte flights
Dallas/Fort Worth to Charlotte flights
LaGuardia to Savannah flights
Dulles Intl to Charleston flights
John F Kennedy Intl to Myrtle Beach flights
Denver to Charlotte flights
Boston to Myrtle Beach flights
Newark to Myrtle Beach flights
Philadelphia to Charleston flights
Hobby to Charlotte flights
White Plains to Charleston flights
Reagan-National to Charleston flights
George Bush Intcntl to Charlotte flights
LaGuardia to Myrtle Beach flights
O'Hare Intl to Myrtle Beach flights
Denver to Charleston flights
Los Angeles to Charlotte flights
Baltimore to Charlotte flights
Detroit to Myrtle Beach flights
Baltimore to Charleston flights
Seattle to Charlotte flights
Providence to Charleston flights
Minneapolis to Charlotte flights
Denver to Savannah flights
Dulles Intl to Savannah flights
Philadelphia to Myrtle Beach flights
Newark to Greenville flights
Reagan-National to Savannah flights
Philadelphia to Savannah flights
Dulles Intl to Charlotte flights
Minneapolis to Savannah flights
Cleveland to Charlotte flights
Baltimore to Savannah flights
Providence to Myrtle Beach flights
LaGuardia to Greenville flights
Detroit to Charlotte flights
Detroit to Charleston flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.