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$387+ Cheap flights from Mississippi to Florence, SC (FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/4. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — FLO
Aug 5 — Aug 121
Tue 8/5
Tue 8/12
1 adult, Economy
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Cheap flight deals from Mississippi to Florence

Keep the following information in mind while searching for Mississippi to Florence flight deals. Data was last updated July 31, 2025.

Round-trip from

$387
(American Airlines)
From Mississippi to Florence
Search Deals

Find flight deals from Mississippi to Florence

Cheapest flights from Mississippi to Florence
Explore the most affordable flight options available from Mississippi to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 31, 2025.

This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/46:08 pmMEM - FLO
1 stop4h 08mAmerican Airlines
Sat 10/112:29 pmFLO - MEM
1 stop4h 36mAmerican Airlines
Deal found 7/30$387
This American Airlines deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:24 amJAN - FLO
1 stop3h 53mAmerican Airlines
Fri 1/25:08 amFLO - JAN
1 stop6h 16mAmerican Airlines
Deal found 7/30$435
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/16:32 pmBTR - FLO
1 stop4h 27mAmerican Airlines
Tue 8/52:34 pmFLO - BTR
2 stops9h 37mAmerican Airlines
Deal found 7/29$471

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 31, 2025.
Use the filters below to find and compare flights from Mississippi to Florence that are best for you.

Fly from

Mississippi

Fly to

Florence

Route

Depart

Return

Price

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Sat 10/4

6:08 pm-11:16 pm

1 stop4h 08m

Florence

Sat 10/11

2:29 pm-6:05 pm

1 stop4h 36m

$387

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Mon 12/22

5:24 am-10:17 am

1 stop3h 53m

Florence

Fri 1/2

5:08 am-10:24 am

1 stop6h 16m

$435

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/30

Best time to book a flight from Mississippi to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Florence

What is the cheapest month to book a flight from Mississippi to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Mississippi to Florence, South Carolina (average of $366). Flying from Mississippi to Florence, South Carolina in October is currently the most expensive (average of $481). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing Florence

Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated July 31, 2025.
Get a feel of what it's like to fly with American Airlines from Mississippi to Florence by reading reviews from past customers. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Boarding

7.5

Food

6.5

Crew

8.0

Overall

7.2

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Andrew,May 2025

LAX - MIA

2 hour delay. Discovered an engine problem late, we boarded the plane and they asked us to come off. To add insult to injury nothing was given to passengers to make amends. No free drink. No extra food or snacks. No free WiFi. Gimme a break
American Airlines
7.2
Good
10,000 reviews
American Airlines
7.2
Good
10,000 reviews

Comfort

7.2

Boarding

7.5

Food

6.5

Crew

8.0

Overall

7.2

Entertainment

6.9

Reviews

1 / 20
2.0
Mediocre

Andrew,May 2025

LAX - MIA

2 hour delay. Discovered an engine problem late, we boarded the plane and they asked us to come off. To add insult to injury nothing was given to passengers to make amends. No free drink. No extra food or snacks. No free WiFi. Gimme a break

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Mississippi?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly into when you book flights from Mississippi to Florence.

  • What are the most popular routes from Mississippi to Florence, South Carolina?

    The most popular flight routes from Mississippi to Florence, South Carolina are Memphis - Florence, Baton Rouge Ryan - Florence and Jackson-Evers Intl - Florence.

  • Can I find deals for flights from Mississippi to Florence that include hotel bookings?

    Yes. In addition to deals on Mississippi to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Florence.

  • Can I find deals for business class flights from Mississippi to Florence?

    Yes. Cheapflights offers flight deals from Mississippi to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Mississippi to Florence, South Carolina (average of $366). Flying from Mississippi to Florence, South Carolina in October is currently the most expensive (average of $481). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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