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$342+ Cheap flights from Mississippi to Florence, SC (FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — FLO
Oct 16 — Oct 231
Thu 10/16
Thu 10/23
1 adult, Economy
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Cheap flight deals from Mississippi to Florence

Keep the following information in mind while searching for Mississippi to Florence flight deals. Data was last updated September 16, 2025.

Round-trip from

$407
(American Airlines)

One-way from

$342
(American Airlines)
From Mississippi to Florence
Search Deals
One-way flight from Mississippi to Florence
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Find flight deals from Mississippi to Florence

Cheapest flights from Mississippi to Florence
Explore the most affordable flight options available from Mississippi to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/49:48 amMEM - FLO
1 stop6h 24mAmerican Airlines
Sat 10/112:29 pmFLO - MEM
1 stop4h 37mAmerican Airlines
Deal found 9/14$407
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:00 amMEM - FLO
1 stop6h 26mAmerican Airlines
Fri 1/25:15 amFLO - MEM
1 stop4h 32mAmerican Airlines
Deal found 9/14$411
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:10 amJAN - FLO
1 stop6h 16mAmerican Airlines
Fri 1/26:30 pmFLO - JAN
1 stop6h 42mAmerican Airlines
Deal found 9/16$411
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/227:05 amMEM - FLO
1 stop4h 21mAmerican Airlines
Fri 1/26:30 pmFLO - MEM
1 stop6h 26mAmerican Airlines
Deal found 9/14$435
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/810:00 amJAN - FLO
1 stop3h 54mAmerican Airlines
Sun 10/125:14 amFLO - JAN
1 stop6h 22mAmerican Airlines
Deal found 9/14$442
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:10 amJAN - FLO
1 stop6h 16mAmerican Airlines
Fri 1/26:30 pmFLO - JAN
1 stop6h 42mAmerican Airlines
Deal found 9/14$456
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/227:05 amMEM - FLO
1 stop4h 21mAmerican Airlines
Sun 1/46:30 pmFLO - MEM
1 stop6h 26mAmerican Airlines
Deal found 9/14$475
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:08 pmMEM - FLO
1 stop4h 08mAmerican Airlines
Sat 10/46:14 amFLO - MEM
2 stops11h 34mAmerican Airlines
Deal found 9/15$587

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 16, 2025.
Use the filters below to find and compare flights from Mississippi to Florence that are best for you.

Fly from

Mississippi

Fly to

Florence

Route

Depart

Return

Price

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Tue 9/30

9:48 am-5:12 pm

1 stop6h 24m

Florence

Sat 10/4

5:37 pm-10:59 pm

1 stop6h 22m

$407

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Sat 10/4

9:48 am-5:12 pm

1 stop6h 24m

Florence

Sat 10/11

2:29 pm-6:06 pm

1 stop4h 37m

$407

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Tue 12/23

6:58 pm-12:15 am

1 stop4h 17m

Florence

Fri 1/2

5:15 am-8:47 am

1 stop4h 32m

$411

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Tue 12/23

5:10 am-12:26 pm

1 stop6h 16m

Florence

Fri 1/2

6:30 pm-12:12 am

1 stop6h 42m

$411

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Mon 12/22

7:05 am-12:26 pm

1 stop4h 21m

Florence

Fri 1/2

6:30 pm-11:56 pm

1 stop6h 26m

$435

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Wed 10/8

10:00 am-2:54 pm

1 stop3h 54m

Florence

Sun 10/12

5:14 am-10:36 am

1 stop6h 22m

$442

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Mon 12/22

5:10 am-12:26 pm

1 stop6h 16m

Florence

Fri 1/2

6:30 pm-12:12 am

1 stop6h 42m

$456

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Mon 12/22

7:05 am-12:26 pm

1 stop4h 21m

Florence

Sun 1/4

6:30 pm-11:56 pm

1 stop6h 26m

$475

JacksonFlorence

JAN - FLO

JANFLO

Jackson-Evers Intl

Wed 10/15

8:08 am-2:54 pm

1 stop5h 46m

$342

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Best time to book a flight from Mississippi to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Florence

What is the cheapest month to book a flight from Mississippi to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Mississippi to Florence, South Carolina (average of $366). Flying from Mississippi to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Florence from Mississippi?

    Florence (FLO), located 2.3 mi from the city center, is the airport you fly into when you book flights from Mississippi to Florence.

  • How long is the flight from Mississippi to Florence, South Carolina?

    American Airlines can get you from Mississippi to Florence, South Carolina in just under 6h 24m. Your travel time can differ by up to . The distance between Mississippi and Florence, South Carolina is about 586 mi.

  • What are the most popular routes from Mississippi to Florence, South Carolina?

    The most popular flight routes from Mississippi to Florence, South Carolina are Memphis - Florence, Jackson-Evers Intl - Florence and Baton Rouge Ryan - Florence.

  • Can I find deals for flights from Mississippi to Florence that include hotel bookings?

    Yes. In addition to deals on Mississippi to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Florence.

  • Can I find deals for business class flights from Mississippi to Florence?

    Yes. Cheapflights offers flight deals from Mississippi to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Mississippi to Florence, South Carolina (average of $366). Flying from Mississippi to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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