$110+ Cheap flights from Mississippi to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/2. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — CHS
Oct 22 — Oct 291
Round-trip
1 adult, Economy
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Find cheap flights from Mississippi to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Mississippi to South Carolina
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Cheapest flights from Mississippi to South CarolinaExplore the most affordable flight options available from Mississippi to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
Explore the most affordable flight options available from Mississippi to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/25:48 pm -
1 stop4h 03m
Mon 11/97:26 pm -
1 stop4h 17m
Deal found 9/18![American Airlines logo]()
$308
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:45 pm -
1 stop12h 03m
Sun 12/139:39 pm -
1 stop12h 12m
Deal found 9/20![Breeze Airways logo]()
$315
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:45 pm -
1 stop4h 12m
Mon 10/197:04 pm -
1 stop5h 51m
Deal found 9/21![American Airlines logo]()
$326
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:46 pm -
1 stop17h 38m
Tue 10/206:00 pm -
2 stops50h 05m
Deal found 9/18![Multiple Airlines logo]()
$338
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/169:18 am -
1 stop2h 56m
Fri 10/237:19 pm -
1 stop4h 50m
Deal found 9/18![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:05 pm -
1 stop3h 46m
Tue 10/275:40 am -
1 stop4h 37m
Deal found 9/21![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:15 am -
1 stop3h 53m
Sun 12/136:02 pm -
1 stop4h 55m
Deal found 9/19![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/211:45 am -
1 stop5h 45m
Mon 11/95:30 am -
2 stops15h 15m
Deal found 9/18![Southwest logo]()
$340
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:45 pm -
1 stop4h 12m
Fri 10/167:04 pm -
1 stop5h 51m
Deal found 9/17![American Airlines logo]()
$351
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/221:46 pm -
1 stop5h 35m
Sat 10/245:40 am -
1 stop4h 37m
Deal found 9/20![Delta logo]()
$353
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/99:21 am -
1 stop4h 49m
Sun 12/136:19 am -
1 stop5h 10m
Deal found 9/21![Delta logo]()
$353
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/141:04 pm -
1 stop4h 01m
Sun 10/185:30 am -
1 stop4h 03m
Deal found 9/20![Delta logo]()
$363
Best flights from Mississippi to South CarolinaDiscover carefully curated flight deals from Mississippi to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
Discover carefully curated flight deals from Mississippi to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:46 pm -
1 stop17h 38m
Tue 10/206:00 pm -
2 stops50h 05m
Deal found 9/18![Multiple Airlines logo]()
$338
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/161:04 pm -
1 stop3h 10m
Fri 10/235:59 pm -
1 stop6h 10m
Deal found 9/19![Delta logo]()
$339
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:45 pm -
1 stop4h 12m
Fri 10/167:04 pm -
1 stop5h 51m
Deal found 9/17![American Airlines logo]()
$351
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/21:57 pm -
1 stop6h 49m
Wed 2/37:00 am -
1 stop7h 23m
Deal found 9/21![United Airlines logo]()
$369
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/25:40 am -
2 stops11h 50m
Mon 11/95:30 am -
2 stops15h 15m
Deal found 9/18![Southwest logo]()
$377
This Kiwi.com deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/47:45 pm -
1 stop12h 00m
Thu 10/86:25 pm -
1 stop15h 26m
Deal found 9/19![Breeze Airways logo]()
$439
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:15 am -
1 stop3h 53m
Sun 12/136:02 pm -
1 stop4h 55m
Deal found 9/19![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/101:24 pm -
1 stop3h 30m
Sun 12/135:10 am -
1 stop6h 19m
Deal found 9/19![Delta logo]()
$353
This Southwest deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/255:45 am -
2 stops10h 50m
Tue 10/277:15 am -
2 stops11h 45m
Deal found 9/20![Southwest logo]()
$416
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/228:54 pm -
1 stop10h 44m
Tue 12/298:35 am -
2 stops12h 39m
Deal found 9/20![Multiple Airlines logo]()
$424
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/99:21 am -
1 stop4h 49m
Sun 12/136:19 am -
1 stop5h 10m
Deal found 9/20![Delta logo]()
$353
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:42 pm -
1 stop4h 23m
Mon 11/28:12 am -
1 stop6h 06m
Deal found 9/21![American Airlines logo]()
$443
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/231:54 pm -
1 stop6h 52m
Wed 1/277:00 am -
1 stop7h 26m
Deal found 9/21![United Airlines logo]()
$473
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1012:43 pm -
1 stop5h 59m
Sun 12/138:32 pm -
1 stop4h 25m
Deal found 9/20![American Airlines logo]()
$450
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:33 pm -
1 stop6h 18m
Sun 10/185:30 am -
1 stop4h 03m
Deal found 9/19![Delta logo]()
$383
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/125:55 am -
2 stops9h 10m
Fri 10/165:35 am -
1 stop6h 50m
Deal found 9/17![Southwest logo]()
$479
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/151:55 pm -
1 stop7h 04m
Wed 12/166:30 am -
1 stop5h 53m
Deal found 9/17![United Airlines logo]()
$502
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:05 pm -
1 stop3h 46m
Thu 10/227:14 pm -
1 stop4h 02m
Deal found 9/21![Delta logo]()
$393
This Southwest deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1512:00 pm -
2 stops11h 20m
Mon 10/195:35 am -
2 stops15h 15m
Deal found 9/20![Southwest logo]()
$490
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/22:00 pm -
1 stop7h 21m
Sat 10/37:00 am -
1 stop7h 25m
Deal found 9/21![United Airlines logo]()
$506
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2212:49 pm -
1 stop6h 04m
Sat 10/246:02 pm -
1 stop6h 57m
Deal found 9/17![American Airlines logo]()
$531
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:05 pm -
1 stop4h 54m
Tue 10/2012:40 pm -
1 stop5h 40m
Deal found 9/18![Delta logo]()
$432
This Southwest deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/212:00 pm -
2 stops8h 30m
Tue 10/67:00 am -
2 stops14h 00m
Deal found 9/17![Southwest logo]()
$535
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/84:34 pm -
1 stop4h 47m
Fri 3/127:02 pm -
1 stop5h 50m
Deal found 9/18![American Airlines logo]()
$565
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/301:54 pm -
1 stop6h 52m
Wed 2/37:00 am -
1 stop7h 26m
Deal found 9/19![United Airlines logo]()
$572
This Delta deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/266:05 pm -
1 stop3h 46m
Mon 11/28:50 am -
1 stop6h 31m
Deal found 9/19![Delta logo]()
$443
This Southwest deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/612:55 pm -
1 stop5h 35m
Sat 10/108:25 am -
2 stops7h 20m
Deal found 9/21![Southwest logo]()
$548
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/303:59 pm -
1 stop21h 46m
Sun 11/17:00 am -
1 stop9h 29m
Deal found 9/19![American Airlines logo]()
$611
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/64:55 pm -
2 stops23h 05m
Mon 11/95:37 pm -
2 stops23h 31m
Deal found 9/17![United Airlines logo]()
$781
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/1310:03 am -
1 stop4h 05m
Thu 10/157:19 pm -
1 stop3h 57m
Deal found 9/18![Delta logo]()
$591
Last-minute flights from Mississippi to South CarolinaDiscover last-minute flight deals from Mississippi to South Carolina. Data last updated September 22, 2026 and is based on user searches.
Discover last-minute flight deals from Mississippi to South Carolina. Data last updated September 22, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:14 pm -
1 stop5h 35m
Wed 10/75:59 pm -
1 stop6h 10m
Deal found 9/18![Delta logo]()
$369
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:42 pm -
1 stop4h 23m
Wed 10/78:30 pm -
1 stop4h 29m
Deal found 9/18![American Airlines logo]()
$369
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/126:45 pm -
1 stop4h 12m
Fri 10/167:04 pm -
1 stop5h 51m
Deal found 9/17![American Airlines logo]()
$351
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/146:45 pm -
1 stop4h 12m
Mon 10/197:04 pm -
1 stop5h 51m
Deal found 9/21![American Airlines logo]()
$326
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/141:04 pm -
1 stop4h 01m
Sun 10/185:30 am -
1 stop4h 03m
Deal found 9/20![Delta logo]()
$363
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:33 pm -
1 stop6h 18m
Sun 10/185:30 am -
1 stop4h 03m
Deal found 9/22![Delta logo]()
$383
This Kiwi.com deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:46 pm -
1 stop17h 38m
Tue 10/206:00 pm -
2 stops50h 05m
Deal found 9/18![Multiple Airlines logo]()
$338
This Delta deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/169:18 am -
1 stop2h 56m
Fri 10/237:19 pm -
1 stop4h 50m
Deal found 9/18![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:05 pm -
1 stop3h 46m
Tue 10/275:40 am -
1 stop4h 37m
Deal found 9/21![Delta logo]()
$339
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/216:05 pm -
1 stop3h 46m
Thu 10/227:14 pm -
1 stop4h 02m
Deal found 9/21![Delta logo]()
$393
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/221:46 pm -
1 stop5h 35m
Sat 10/245:40 am -
1 stop4h 37m
Deal found 9/20![Delta logo]()
$353
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/256:45 pm -
1 stop4h 20m
Tue 10/275:37 pm -
1 stop6h 48m
Deal found 9/20![American Airlines logo]()
$353
One-way flights from Mississippi to South CarolinaSearch for one-way flight options from Mississippi to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
Search for one-way flight options from Mississippi to South Carolina. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:46 pm -
1 stop16h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Breeze Airways logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:46 pm -
1 stop17h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Breeze Airways logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/157:45 pm -
2 stops45h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Breeze Airways logo]()
$174
This Kiwi.com deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:46 pm -
3 stops36h 52m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Multiple Airlines logo]()
$182
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:05 pm -
1 stop3h 46m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/22![Delta logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:45 pm -
1 stop19h 02m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Breeze Airways logo]()
$201
This Delta deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:05 pm -
1 stop4h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![Delta logo]()
$222
This Kiwi.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/17:45 pm -
3 stops42h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Multiple Airlines logo]()
$247
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/23:27 pm -
1 stop4h 39m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![American Airlines logo]()
$249
This Southwest deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/212:00 pm -
2 stops8h 40m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/18![Southwest logo]()
$254
This American Airlines deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/226:00 am -
1 stop6h 36m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![American Airlines logo]()
$273
This Delta deal was found by Cheapflights users on 9/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/33:02 pm -
1 stop4h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/20![Delta logo]()
$309
Find flight deals from Mississippi to South Carolina
Keep the following information in mind while searching for Mississippi to South Carolina flight deals. Data was last updated September 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $281 (Southwest) |
One-way from | $110 (Kiwi.com) |
Popular in | June |
Cheapest in | February |
Average price | $366 |
Cheapflights Fare Finder
Customize your flight search to find flights from Mississippi to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
Use the filters below to find and compare flights from Mississippi to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GulfportCharleston
GPT Gulfport Biloxi Regional - CHS Charleston
GPTCHS
Gulfport Biloxi Regional
Mon 11/2
6:46 pm-12:31 pm
1 stop16h 45m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$110
GulfportCharleston
GPT Gulfport Biloxi Regional - CHS Charleston
GPTCHS
Gulfport Biloxi Regional
Fri 10/2
6:46 pm-1:24 pm
1 stop17h 38m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$163
GulfportGreenville
GPT Gulfport Biloxi Regional - GSP Greenville
GPTGSP
Gulfport Biloxi Regional
Mon 10/19
6:26 am-1:00 pm
1 stop5h 34m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$184
GulfportGreenville
GPT Gulfport Biloxi Regional - GSP Greenville
GPTGSP
Gulfport Biloxi Regional
Wed 10/21
6:05 pm-10:51 pm
1 stop3h 46m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$184
GulfportGreenville
GPT Gulfport Biloxi Regional - GSP Greenville
GPTGSP
Gulfport Biloxi Regional
Thu 10/15
6:05 pm-10:51 pm
1 stop3h 46m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$184
GulfportGreenville
GPT Gulfport Biloxi Regional - GSP Greenville
GPTGSP
Gulfport Biloxi Regional
Sun 11/1
7:45 pm-3:47 pm
1 stop19h 02m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$201
GulfportCharleston
GPT Gulfport Biloxi Regional - CHS Charleston
GPTCHS
Gulfport Biloxi Regional
Tue 11/3
5:32 pm-10:51 pm
1 stop4h 19m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$222
GulfportCharleston
GPT Gulfport Biloxi Regional - CHS Charleston
GPTCHS
Gulfport Biloxi Regional
Mon 10/19
6:05 pm-11:59 pm
1 stop4h 54m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$222
GulfportCharleston
GPT Gulfport Biloxi Regional - CHS Charleston
GPTCHS
Gulfport Biloxi Regional
Thu 10/15
7:45 pm-1:24 pm
3 stops40h 39m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$232
GulfportGreenville
GPT Gulfport Biloxi Regional - GSP Greenville
GPTGSP
Gulfport Biloxi Regional
Sun 11/1
7:45 pm-3:29 pm
3 stops42h 44m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$247
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Mississippi to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Mississippi with our price prediction graph.
GPT-CHS
JAN-CAE
JAN-CHS
JAN-GSP
GPT-MYR
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mississippi to South Carolina
USMS-USSC
GPT-CHS
JAN-CAE
JAN-CHS
JAN-GSP
What is the cheapest month to book a flight from Mississippi to South Carolina?
Currently, February is the cheapest month in which you can book a flight from Mississippi to South Carolina (average of $303). Flying from Mississippi to South Carolina in June is currently the most expensive (average of $686). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated September 22, 2026.
See what other customers who have flown with Southwest and Delta from Mississippi to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Overall
8.0
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Entertainment
7.5
Overall
8.0
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Entertainment
7.5
Overall
8.0
Comfort
8.0
Boarding
8.1
Food
7.0
Crew
8.6
Reviews
1 / 20
4.0
OkaySteven,Sep 2026
OGG - HNL
Related info for your journey
Find useful and relevant information for your journey from Mississippi to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Mississippi to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Mississippi to South Carolina by cabin class
Find flights from Mississippi to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Mississippi and South Carolina flights
Browse other Mississippi and South Carolina flight options. Last updated on September 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Mississippi after your stay in South Carolina
Mississippi to South Carolina flights
Consider these flights traveling from Mississippi to South Carolina.
Top 2 airlines flying from Mississippi to South Carolina
Discover the top 2 airlines that operate flights from Mississippi to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$248 | Average$479 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$254 | Average$392 | FlexibilityNo cancel fee | On-time63% |