$149+ Cheap flights from Mississippi to South Carolina
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/7. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — CHS
Dec 10 — Dec 171
Round-trip
1 adult, Economy
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Find cheap flights from Mississippi to South Carolina with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest flights from Mississippi to South CarolinaExplore the most affordable flight options available from Mississippi to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 10, 2026.
Explore the most affordable flight options available from Mississippi to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 10, 2026.
This Breeze Airways deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:45 pm -
1 stop12h 00m
Sun 12/136:25 pm -
1 stop15h 26m
Deal found 11/6![Breeze Airways logo]()
$222
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:09 pm -
1 stop4h 55m
Tue 12/85:34 pm -
1 stop5h 23m
Deal found 11/8![Delta logo]()
$297
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/11:24 pm -
1 stop4h 58m
Fri 12/46:59 pm -
1 stop5h 06m
Deal found 11/5![Delta logo]()
$309
This Breeze Airways deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:45 pm -
1 stop12h 03m
Sun 12/139:39 pm -
1 stop12h 12m
Deal found 11/8![Breeze Airways logo]()
$311
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/51:05 pm -
1 stop4h 55m
Tue 12/86:35 am -
2 stops6h 55m
Deal found 11/5![Southwest logo]()
$314
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:53 pm -
1 stop4h 08m
Mon 12/77:40 pm -
1 stop4h 08m
Deal found 11/9![American Airlines logo]()
$317
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/54:00 pm -
1 stop4h 07m
Thu 12/105:10 am -
1 stop5h 09m
Deal found 11/8![Delta logo]()
$327
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/51:05 pm -
1 stop4h 05m
Mon 12/77:05 am -
2 stops13h 50m
Deal found 11/9![Southwest logo]()
$329
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/91:10 pm -
1 stop5h 25m
Fri 12/1111:00 am -
2 stops9h 45m
Deal found 11/5![Southwest logo]()
$332
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:30 am -
1 stop6h 28m
Sun 12/135:04 am -
1 stop6h 20m
Deal found 11/5![American Airlines logo]()
$346
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:09 pm -
1 stop3h 13m
Mon 12/145:40 am -
1 stop4h 39m
Deal found 11/9![Delta logo]()
$349
This American Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/45:25 pm -
1 stop5h 33m
Mon 12/75:17 pm -
1 stop6h 26m
Deal found 11/7![American Airlines logo]()
$349
Best flights from Mississippi to South CarolinaDiscover carefully curated flight deals from Mississippi to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 10, 2026.
Discover carefully curated flight deals from Mississippi to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 10, 2026.
This Breeze Airways deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:45 pm -
1 stop12h 00m
Sun 12/136:25 pm -
1 stop15h 26m
Deal found 11/6![Breeze Airways logo]()
$222
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/306:04 pm -
1 stop4h 55m
Thu 12/36:24 am -
1 stop3h 55m
Deal found 11/5![Delta logo]()
$297
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/141:10 pm -
1 stop5h 25m
Thu 12/175:30 am -
1 stop6h 35m
Deal found 11/5![Southwest logo]()
$309
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/151:55 pm -
1 stop7h 04m
Wed 12/166:30 am -
1 stop5h 53m
Deal found 11/5![United Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/35:25 pm -
1 stop5h 31m
Thu 12/106:51 am -
1 stop5h 38m
Deal found 11/5![American Airlines logo]()
$419
This Delta deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/110:30 am -
1 stop5h 37m
Tue 1/57:01 am -
1 stop3h 48m
Deal found 11/6![Delta logo]()
$297
This Breeze Airways deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:45 pm -
1 stop12h 03m
Sun 12/139:39 pm -
1 stop12h 12m
Deal found 11/8![Breeze Airways logo]()
$311
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/51:05 pm -
1 stop4h 55m
Tue 12/86:35 am -
2 stops6h 55m
Deal found 11/5![Southwest logo]()
$314
This Delta deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/54:00 pm -
1 stop4h 07m
Wed 12/94:17 pm -
1 stop6h 40m
Deal found 11/6![Delta logo]()
$297
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/61:10 pm -
1 stop5h 05m
Sat 1/98:25 am -
2 stops9h 30m
Deal found 11/5![Southwest logo]()
$314
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/95:20 am -
1 stop5h 30m
Fri 12/115:10 am -
1 stop4h 26m
Deal found 11/5![Delta logo]()
$309
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/91:10 pm -
1 stop5h 25m
Fri 12/1111:00 am -
2 stops9h 45m
Deal found 11/5![Southwest logo]()
$332
This United Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/57:00 am -
1 stop7h 17m
Wed 12/95:00 pm -
1 stop5h 41m
Deal found 11/7![United Airlines logo]()
$443
This Trip.com deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/114:48 pm -
1 stop5h 18m
Sat 1/165:18 pm -
1 stop5h 50m
Deal found 11/8![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/56:30 am -
2 stops8h 30m
Mon 12/77:05 am -
2 stops13h 50m
Deal found 11/9![Southwest logo]()
$349
This Kiwi.com deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/56:46 pm -
2 stops14h 12m
Sun 3/78:43 pm -
1 stop13h 08m
Deal found 11/9![Breeze Airways logo]()
$462
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:09 pm -
1 stop3h 13m
Mon 12/145:40 am -
1 stop4h 39m
Deal found 11/9![Delta logo]()
$349
This United Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/231:54 pm -
1 stop7h 05m
Thu 11/266:49 am -
1 stop7h 29m
Deal found 11/9![United Airlines logo]()
$473
This Southwest deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/205:35 am -
2 stops10h 35m
Mon 2/221:15 pm -
2 stops8h 40m
Deal found 11/7![Southwest logo]()
$364
This Delta deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:09 pm -
1 stop4h 42m
Sun 12/136:02 pm -
1 stop4h 55m
Deal found 11/6![Delta logo]()
$349
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/75:42 pm -
1 stop4h 19m
Mon 12/146:55 am -
2 stops11h 22m
Deal found 11/9![American Airlines logo]()
$618
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/185:20 am -
1 stop5h 30m
Mon 12/215:15 am -
1 stop4h 26m
Deal found 11/8![Delta logo]()
$373
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/211:58 am -
1 stop9h 01m
Sat 12/56:30 am -
1 stop7h 50m
Deal found 11/5![United Airlines logo]()
$574
This Delta deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/227:51 am -
1 stop4h 23m
Thu 11/268:00 am -
1 stop5h 40m
Deal found 11/7![Delta logo]()
$379
This United Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/234:55 pm -
1 stop22h 23m
Wed 1/276:30 am -
1 stop7h 54m
Deal found 11/7![United Airlines logo]()
$653
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/246:04 pm -
1 stop4h 55m
Sat 11/287:04 pm -
1 stop3h 48m
Deal found 11/9![Delta logo]()
$412
This American Airlines deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/53:59 pm -
2 stops22h 22m
Sun 12/65:17 pm -
1 stop23h 08m
Deal found 11/8![American Airlines logo]()
$838
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/236:45 am -
2 stops25h 33m
Wed 1/276:30 am -
1 stop7h 54m
Deal found 11/5![United Airlines logo]()
$685
This Delta deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/412:56 pm -
1 stop5h 57m
Sun 3/75:30 am -
1 stop4h 04m
Deal found 11/6![Delta logo]()
$427
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/2411:30 am -
1 stop6h 55m
Sat 11/288:10 am -
2 stops12h 30m
Deal found 11/9![Southwest logo]()
$678
Last-minute flights from Mississippi to South CarolinaDiscover last-minute flight deals from Mississippi to South Carolina. Data last updated November 10, 2026 and is based on user searches.
Discover last-minute flight deals from Mississippi to South Carolina. Data last updated November 10, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/11:24 pm -
1 stop4h 58m
Fri 12/46:59 pm -
1 stop5h 06m
Deal found 11/5![Delta logo]()
$309
This Breeze Airways deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:45 pm -
1 stop12h 00m
Sun 12/136:25 pm -
1 stop15h 26m
Deal found 11/6![Breeze Airways logo]()
$222
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:09 pm -
1 stop4h 55m
Tue 12/85:34 pm -
1 stop5h 23m
Deal found 11/8![Delta logo]()
$297
This American Airlines deal was found by Cheapflights users on 11/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/45:25 pm -
1 stop5h 33m
Mon 12/75:17 pm -
1 stop6h 26m
Deal found 11/7![American Airlines logo]()
$349
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/51:05 pm -
1 stop4h 55m
Tue 12/86:35 am -
2 stops6h 55m
Deal found 11/5![Southwest logo]()
$314
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/55:53 pm -
1 stop4h 08m
Mon 12/77:40 pm -
1 stop4h 08m
Deal found 11/9![American Airlines logo]()
$317
This Delta deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/54:00 pm -
1 stop4h 07m
Thu 12/105:10 am -
1 stop5h 09m
Deal found 11/8![Delta logo]()
$327
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/51:05 pm -
1 stop4h 05m
Mon 12/77:05 am -
2 stops13h 50m
Deal found 11/9![Southwest logo]()
$329
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/76:09 pm -
1 stop3h 13m
Mon 12/145:40 am -
1 stop4h 39m
Deal found 11/9![Delta logo]()
$349
This Southwest deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/91:10 pm -
1 stop5h 25m
Fri 12/1111:00 am -
2 stops9h 45m
Deal found 11/5![Southwest logo]()
$332
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/97:30 am -
1 stop6h 28m
Sun 12/135:04 am -
1 stop6h 20m
Deal found 11/5![American Airlines logo]()
$346
This Breeze Airways deal was found by Cheapflights users on 11/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Breeze Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/107:45 pm -
1 stop12h 03m
Sun 12/139:39 pm -
1 stop12h 12m
Deal found 11/8![Breeze Airways logo]()
$311
One-way flights from Mississippi to South CarolinaSearch for one-way flight options from Mississippi to South Carolina. Find affordable one-way fares based on user searches. Data last updated November 10, 2026.
Search for one-way flight options from Mississippi to South Carolina. Find affordable one-way fares based on user searches. Data last updated November 10, 2026.
This Delta deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/76:00 am -
1 stop6h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/6![Delta logo]()
$149
This Delta deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1711:26 am -
1 stop4h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Delta logo]()
$152
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/176:45 am -
2 stops10h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Southwest logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:46 pm -
1 stop16h 45m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![Breeze Airways logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:46 pm -
3 stops21h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![Multiple Airlines logo]()
$253
This American Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/32:59 pm -
1 stop6h 17m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![American Airlines logo]()
$289
This American Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/71:53 pm -
2 stops9h 06m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/6![American Airlines logo]()
$343
This American Airlines deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/216:30 pm -
1 stop4h 25m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![American Airlines logo]()
$369
This Southwest deal was found by Cheapflights users on 11/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/2111:40 am -
2 stops11h 35m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/9![Southwest logo]()
$374
This United Airlines deal was found by Cheapflights users on 11/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/76:45 am -
3 stops31h 28m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/6![United Airlines logo]()
$468
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/37:00 am -
2 stops33h 09m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 11/5![United Airlines logo]()
$515
Find flight deals from Mississippi to South Carolina
Keep the following information in mind while searching for Mississippi to South Carolina flight deals. Data was last updated November 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $222 (Breeze Airways) |
One-way from | $149 (Delta) |
Cheapflights Fare Finder
Customize your flight search to find flights from Mississippi to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 10, 2026.
Use the filters below to find and compare flights from Mississippi to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
GulfportCharleston
GPT Gulfport Biloxi Regional - CHS Charleston
GPTCHS
Gulfport Biloxi Regional
Thu 1/7
6:00 am-1:29 pm
1 stop6h 29m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$149
Quickest round-trip
JacksonGreenville
JAN Jackson-Evers Intl - GSP Greenville
JANGSP
Jackson-Evers Intl
Wed 2/17
11:26 am-4:35 pm
1 stop4h 09m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$152
JacksonGreenville
JAN Jackson-Evers Intl - GSP Greenville
JANGSP
Jackson-Evers Intl
Wed 2/17
6:45 am-6:15 pm
2 stops10h 30m
Greenville
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$157
GulfportMyrtle Beach
GPT Gulfport Biloxi Regional - MYR Myrtle Beach Intl
GPTMYR
Gulfport Biloxi Regional
Thu 12/3
7:45 pm-8:45 am
1 stop12h 00m
Myrtle Beach Intl
Sun 12/13
6:25 pm-8:51 am
1 stop15h 26m
$222
GulfportCharleston
GPT Gulfport Biloxi Regional - CHS Charleston
GPTCHS
Gulfport Biloxi Regional
Mon 11/16
6:46 pm-5:20 pm
3 stops21h 34m
Charleston
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$253
JacksonColumbia
JAN Jackson-Evers Intl - CAE Columbia Metropolitan
JANCAE
Jackson-Evers Intl
Thu 12/3
2:59 pm-10:16 pm
1 stop6h 17m
Columbia Metropolitan
Wed 12/31
12:00 am-11:00 pm
Nonstop0h 00m
$289
GulfportCharleston
GPT Gulfport Biloxi Regional - CHS Charleston
GPTCHS
Gulfport Biloxi Regional
Mon 11/30
6:04 pm-11:59 pm
1 stop4h 55m
Charleston
Thu 12/3
6:24 am-9:19 am
1 stop3h 55m
$297
GulfportCharleston
GPT Gulfport Biloxi Regional - CHS Charleston
GPTCHS
Gulfport Biloxi Regional
Fri 1/1
10:30 am-5:07 pm
1 stop5h 37m
Charleston
Tue 1/5
7:01 am-9:49 am
1 stop3h 48m
$297
GulfportCharleston
GPT Gulfport Biloxi Regional - CHS Charleston
GPTCHS
Gulfport Biloxi Regional
Sat 12/5
4:00 pm-9:07 pm
1 stop4h 07m
Charleston
Wed 12/9
4:17 pm-9:57 pm
1 stop6h 40m
$297
JacksonCharleston
JAN Jackson-Evers Intl - CHS Charleston
JANCHS
Jackson-Evers Intl
Mon 12/14
1:10 pm-7:35 pm
1 stop5h 25m
Charleston
Thu 12/17
5:30 am-11:05 am
1 stop6h 35m
$309
Showing 1-10 of 41 resultsSorted by cheapest first
Best time to book a flight from Mississippi to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Mississippi with our price prediction graph.
GPT-MYR
GPT-CHS
JAN-CHS
JAN-GSP
GPT-GSP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mississippi to South Carolina
USMS-USSC
GPT-MYR
GPT-CHS
JAN-CHS
JAN-GSP
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated November 10, 2026.
See what other customers who have flown with Delta from Mississippi to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.5
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Food
7.2
Overall
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Crew
8.5
Entertainment
7.8
Comfort
7.8
Boarding
8.1
Food
7.2
Overall
7.8
Reviews
1 / 20
6.0
GoodEllen,Oct 2026
GRR - ATL
Related info for your journey
Find useful and relevant information for your journey from Mississippi to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Mississippi to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Mississippi to South Carolina by cabin class
Find flights from Mississippi to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Mississippi and South Carolina flights
Browse other Mississippi and South Carolina flight options. Last updated on November 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Mississippi after your stay in South Carolina
Mississippi to South Carolina flights
Consider these flights traveling from Mississippi to South Carolina.
Top airline flying from Mississippi to South Carolina
Discover the top airline that operate flights from Mississippi to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated November 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$242 | Average$417 | FlexibilityNo cancel fee | On-timeN/A |