$421+ Cheap flights from Mississippi to South Dakota
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/30. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — FSD
Oct 22 — Oct 291
Round-trip
1 adult, Economy
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Find cheap flights from Mississippi to South Dakota with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Mississippi to South Dakota
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Cheapest flights from Mississippi to South DakotaExplore the most affordable flight options available from Mississippi to South Dakota. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
Explore the most affordable flight options available from Mississippi to South Dakota. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 22, 2026.
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:49 am -
2 stops10h 22m
Sat 10/312:56 pm -
1 stop4h 56m
Deal found 9/18![American Airlines logo]()
$478
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/231:03 pm -
1 stop6h 44m
Tue 9/295:30 am -
1 stop6h 47m
Deal found 9/22![Delta logo]()
$519
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:16 am -
2 stops11h 26m
Tue 9/296:00 am -
1 stop5h 47m
Deal found 9/22![American Airlines logo]()
$569
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/154:46 pm -
1 stop6h 10m
Tue 10/205:04 pm -
1 stop4h 55m
Deal found 9/17![American Airlines logo]()
$593
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:45 am -
1 stop6h 31m
Wed 10/712:53 pm -
1 stop6h 09m
Deal found 9/21![American Airlines logo]()
$617
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/152:09 pm -
2 stops20h 19m
Tue 10/2010:26 am -
2 stops10h 32m
Deal found 9/17![United Airlines logo]()
$715
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/47:02 am -
1 stop5h 14m
Thu 10/86:20 am -
1 stop5h 25m
Deal found 9/19![American Airlines logo]()
$805
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2512:15 pm -
1 stop5h 08m
Sun 11/296:00 am -
1 stop5h 45m
Deal found 9/18![American Airlines logo]()
$811
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/186:22 pm -
2 stops23h 49m
Fri 9/256:41 pm -
2 stops15h 59m
Deal found 9/18![American Airlines logo]()
$863
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/262:00 pm -
2 stops9h 11m
Sat 10/37:50 am -
3 stops11h 48m
Deal found 9/18![United Airlines logo]()
$890
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/612:02 pm -
2 stops11h 28m
Sat 10/105:53 pm -
2 stops16h 34m
Deal found 9/21![United Airlines logo]()
$899
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:40 am -
1 stop5h 14m
Sat 10/105:04 pm -
1 stop4h 55m
Deal found 9/21![American Airlines logo]()
$910
Best flights from Mississippi to South DakotaDiscover carefully curated flight deals from Mississippi to South Dakota that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
Discover carefully curated flight deals from Mississippi to South Dakota that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 22, 2026.
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/307:00 am -
2 stops10h 03m
Wed 2/34:40 pm -
2 stops17h 33m
Deal found 9/21![United Airlines logo]()
$557
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:45 am -
1 stop6h 31m
Wed 10/712:53 pm -
1 stop6h 09m
Deal found 9/21![American Airlines logo]()
$617
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/301:54 pm -
2 stops9h 14m
Wed 2/36:00 am -
2 stops9h 02m
Deal found 9/18![United Airlines logo]()
$647
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/51:54 pm -
2 stops9h 56m
Tue 2/97:40 am -
2 stops8h 22m
Deal found 9/21![United Airlines logo]()
$682
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/47:02 am -
1 stop5h 14m
Thu 10/86:20 am -
1 stop5h 25m
Deal found 9/19![American Airlines logo]()
$805
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/152:09 pm -
2 stops20h 19m
Tue 10/2010:26 am -
2 stops10h 32m
Deal found 9/17![United Airlines logo]()
$715
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/2512:15 pm -
1 stop5h 08m
Sun 11/296:00 am -
1 stop5h 45m
Deal found 9/18![American Airlines logo]()
$811
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:40 am -
1 stop5h 14m
Sat 10/105:04 pm -
1 stop4h 55m
Deal found 9/21![American Airlines logo]()
$910
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/22:09 pm -
2 stops9h 02m
Wed 10/76:00 am -
3 stops10h 25m
Deal found 9/21![United Airlines logo]()
$1,109
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/412:02 pm -
2 stops11h 09m
Thu 10/81:46 pm -
2 stops8h 12m
Deal found 9/19![United Airlines logo]()
$1,207
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/612:02 pm -
3 stops9h 50m
Sat 10/105:00 am -
2 stops10h 25m
Deal found 9/21![United Airlines logo]()
$1,433
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/259:05 am -
3 stops10h 59m
Sun 11/2911:22 am -
2 stops9h 04m
Deal found 9/18![United Airlines logo]()
$1,739
Last-minute flights from Mississippi to South DakotaDiscover last-minute flight deals from Mississippi to South Dakota. Data last updated September 22, 2026 and is based on user searches.
Discover last-minute flight deals from Mississippi to South Dakota. Data last updated September 22, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/231:03 pm -
1 stop6h 44m
Tue 9/295:30 am -
1 stop6h 47m
Deal found 9/22![Delta logo]()
$519
This American Airlines deal was found by Cheapflights users on 9/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/238:16 am -
2 stops11h 26m
Tue 9/296:00 am -
1 stop5h 47m
Deal found 9/22![American Airlines logo]()
$569
This American Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/267:49 am -
2 stops10h 22m
Sat 10/312:56 pm -
1 stop4h 56m
Deal found 9/18![American Airlines logo]()
$478
This United Airlines deal was found by Cheapflights users on 9/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/262:00 pm -
2 stops9h 11m
Sat 10/37:50 am -
3 stops11h 48m
Deal found 9/18![United Airlines logo]()
$890
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/25:45 am -
1 stop6h 31m
Wed 10/712:53 pm -
1 stop6h 09m
Deal found 9/21![American Airlines logo]()
$617
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/22:09 pm -
2 stops9h 02m
Wed 10/76:00 am -
3 stops10h 25m
Deal found 9/21![United Airlines logo]()
$1,109
This American Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/47:02 am -
1 stop5h 14m
Thu 10/86:20 am -
1 stop5h 25m
Deal found 9/19![American Airlines logo]()
$805
This United Airlines deal was found by Cheapflights users on 9/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/412:02 pm -
2 stops11h 09m
Thu 10/81:46 pm -
2 stops8h 12m
Deal found 9/19![United Airlines logo]()
$1,207
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/612:02 pm -
2 stops11h 28m
Sat 10/105:53 pm -
2 stops16h 34m
Deal found 9/21![United Airlines logo]()
$899
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/65:40 am -
1 stop5h 14m
Sat 10/105:04 pm -
1 stop4h 55m
Deal found 9/21![American Airlines logo]()
$910
This American Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/154:46 pm -
1 stop6h 10m
Tue 10/205:04 pm -
1 stop4h 55m
Deal found 9/17![American Airlines logo]()
$593
This United Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/152:09 pm -
2 stops20h 19m
Tue 10/2010:26 am -
2 stops10h 32m
Deal found 9/17![United Airlines logo]()
$715
One-way flights from Mississippi to South DakotaSearch for one-way flight options from Mississippi to South Dakota. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
Search for one-way flight options from Mississippi to South Dakota. Find affordable one-way fares based on user searches. Data last updated September 22, 2026.
This American Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/3012:21 pm -
1 stop7h 21m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![American Airlines logo]()
$421
This United Airlines deal was found by Cheapflights users on 9/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:00 am -
3 stops11h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/21![United Airlines logo]()
$769
Find flight deals from Mississippi to South Dakota
Keep the following information in mind while searching for Mississippi to South Dakota flight deals. Data was last updated September 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $557 (United Airlines) |
One-way from | $421 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Mississippi to South Dakota that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
Use the filters below to find and compare flights from Mississippi to South Dakota that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
JacksonSioux Falls
JAN Jackson-Evers Intl - FSD Sioux Falls Joe Foss Field
JANFSD
Jackson-Evers Intl
Wed 9/30
12:21 pm-7:42 pm
1 stop7h 21m
Sioux Falls Joe Foss Field
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$421
JacksonRapid City
JAN Jackson-Evers Intl - RAP Rapid City
JANRAP
Jackson-Evers Intl
Sat 1/30
7:00 am-4:03 pm
2 stops10h 03m
Rapid City
Wed 2/3
4:40 pm-11:13 am
2 stops17h 33m
$557
JacksonSioux Falls
JAN Jackson-Evers Intl - FSD Sioux Falls Joe Foss Field
JANFSD
Jackson-Evers Intl
Fri 10/2
5:45 am-12:16 pm
1 stop6h 31m
Sioux Falls Joe Foss Field
Wed 10/7
12:53 pm-7:02 pm
1 stop6h 09m
$617
GulfportRapid City
GPT Gulfport Biloxi Regional - RAP Rapid City
GPTRAP
Gulfport Biloxi Regional
Sat 1/30
1:54 pm-10:08 pm
2 stops9h 14m
Rapid City
Wed 2/3
6:00 am-4:02 pm
2 stops9h 02m
$647
GulfportSioux Falls
GPT Gulfport Biloxi Regional - FSD Sioux Falls Joe Foss Field
GPTFSD
Gulfport Biloxi Regional
Fri 2/5
1:54 pm-11:50 pm
2 stops9h 56m
Sioux Falls Joe Foss Field
Tue 2/9
7:40 am-4:02 pm
2 stops8h 22m
$682
JacksonRapid City
JAN Jackson-Evers Intl - RAP Rapid City
JANRAP
Jackson-Evers Intl
Thu 10/15
2:09 pm-9:28 am
2 stops20h 19m
Rapid City
Tue 10/20
10:26 am-9:58 pm
2 stops10h 32m
$715
JacksonSioux Falls
JAN Jackson-Evers Intl - FSD Sioux Falls Joe Foss Field
JANFSD
Jackson-Evers Intl
Wed 9/30
7:00 am-6:15 pm
3 stops11h 15m
Sioux Falls Joe Foss Field
Wed 12/31
12:00 am-12:00 am
Nonstop0h 00m
$769
JacksonSioux Falls
JAN Jackson-Evers Intl - FSD Sioux Falls Joe Foss Field
JANFSD
Jackson-Evers Intl
Sun 10/4
7:02 am-12:16 pm
1 stop5h 14m
Sioux Falls Joe Foss Field
Thu 10/8
6:20 am-11:45 am
1 stop5h 25m
$805
JacksonSioux Falls
JAN Jackson-Evers Intl - FSD Sioux Falls Joe Foss Field
JANFSD
Jackson-Evers Intl
Wed 11/25
12:15 pm-5:23 pm
1 stop5h 08m
Sioux Falls Joe Foss Field
Sun 11/29
6:00 am-11:45 am
1 stop5h 45m
$811
JacksonRapid City
JAN Jackson-Evers Intl - RAP Rapid City
JANRAP
Jackson-Evers Intl
Tue 10/6
5:40 am-9:54 am
1 stop5h 14m
Rapid City
Sat 10/10
5:04 pm-10:59 pm
1 stop4h 55m
$910
Showing 1-10 of 14 resultsSorted by cheapest first
Best time to book a flight from Mississippi to South Dakota
Have a flexible travel schedule? Discover the best time to fly to South Dakota from Mississippi with our price prediction graph.
JAN-FSD
GPT-FSD
JAN-RAP
GPT-RAP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Mississippi to South Dakota
USMS-USSD
JAN-FSD
GPT-FSD
JAN-RAP
GPT-RAP
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing South Dakota
Get insights into the airlines that provide service to South Dakota. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Dakota. Reviews last updated September 22, 2026.
Get a feel of what it's like to fly with American Airlines from Mississippi to South Dakota by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Crew
7.9
Food
6.4
Comfort
7.2
Entertainment
6.8
Overall
7.0
Boarding
7.4
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Crew
7.9
Food
6.4
Comfort
7.2
Entertainment
6.8
Overall
7.0
Boarding
7.4
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Mississippi to South Dakota. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Mississippi to South Dakota
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Complete your trip
Complete your trip to South Dakota by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Mississippi to South Dakota by cabin class
Find flights from Mississippi to South Dakota, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Mississippi and South Dakota flights
Browse other Mississippi and South Dakota flight options. Last updated on September 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Dakota
Find the right flight back to Mississippi after your stay in South Dakota
Mississippi to South Dakota flights
Consider these flights traveling from Mississippi to South Dakota.
Top airline flying from Mississippi to South Dakota
Discover the top airline that operate flights from Mississippi to South Dakota. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$308 | Average$527 | FlexibilityNo cancel fee | On-time71% |