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$407+ Cheap flights from Memphis to Florence, SC (MEM - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/4. Fares are subject to change and may not be available on all flights or dates of travel.
MEM — FLO
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Memphis to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Memphis (MEM) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$407
(American Airlines)
From Memphis to Florence
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Find flight deals from Memphis to Florence

Cheapest flights from Memphis to Florence
Explore the most affordable flight options available from Memphis to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/46:08 pmMEM - FLO
1 stop4h 08mAmerican Airlines
Sat 10/112:29 pmFLO - MEM
1 stop4h 37mAmerican Airlines
Deal found 9/16$407
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/236:58 pmMEM - FLO
1 stop4h 17mAmerican Airlines
Fri 1/25:15 amFLO - MEM
1 stop4h 32mAmerican Airlines
Deal found 9/16$411
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:00 amMEM - FLO
1 stop6h 26mAmerican Airlines
Fri 1/25:15 amFLO - MEM
1 stop4h 32mAmerican Airlines
Deal found 9/16$435
This American Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:00 amMEM - FLO
1 stop6h 26mAmerican Airlines
Sun 1/46:30 pmFLO - MEM
1 stop6h 26mAmerican Airlines
Deal found 9/16$475

Cheapflights Fare Finder

 
Customize your flight search to find flights from Memphis to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Memphis to Florence that are best for you.

Fly from

Memphis

Fly to

Florence

Route

Depart

Return

Price

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Sat 10/4

6:08 pm-11:16 pm

1 stop4h 08m

Florence

Sat 10/11

2:29 pm-6:06 pm

1 stop4h 37m

$407

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Tue 12/23

6:58 pm-12:15 am

1 stop4h 17m

Florence

Fri 1/2

5:15 am-8:47 am

1 stop4h 32m

$411

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Mon 12/22

5:00 am-12:26 pm

1 stop6h 26m

Florence

Fri 1/2

5:15 am-8:47 am

1 stop4h 32m

$435

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Mon 12/22

7:05 am-12:26 pm

1 stop4h 21m

Florence

Sun 1/4

6:30 pm-11:56 pm

1 stop6h 26m

$475

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Best time to book a flight from Memphis to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Memphis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Memphis to Florence

What is the cheapest month to book a flight from Memphis to Florence, South Carolina?

Currently, January is the cheapest month in which you can book a flight from Memphis to Florence, South Carolina (average of $366). Flying from Memphis to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Memphis to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Memphis to Florence, South Carolina?

    For as low as $407, American Airlines can have you in Florence, South Carolina from Memphis in 4h 08m. Memphis and Florence, South Carolina are separated by a distance of 586 mi.

  • Can I find deals for flights from Memphis to Florence that include hotel bookings?

    Yes. In addition to deals on Memphis to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Memphis to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Memphis to Florence.

  • Can I find deals for business class flights from Memphis to Florence?

    Yes. Cheapflights offers flight deals from Memphis to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Memphis to Florence, South Carolina?

    Currently, January is the cheapest month in which you can book a flight from Memphis to Florence, South Carolina (average of $366). Flying from Memphis to Florence, South Carolina in October is currently the most expensive (average of $501). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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