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$382+ Cheap flights from Memphis to Florence, SC (MEM - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/11. Fares are subject to change and may not be available on all flights or dates of travel.
MEM — FLO
Apr 5 — Apr 121
Sun 4/5
Sun 4/12
1 adult, Economy
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Cheap flight deals from Memphis to Florence

Cheapest flights from Memphis to Florence
Explore the most affordable flight options available from Memphis to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 6, 2026.

This American Airlines deal was found by Cheapflights users on 3/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:08 pm
MEM
-
FLO
1 stop4h 49m
American Airlines
Mon 4/66:20 pm
FLO
-
MEM
1 stop6h 31m
American Airlines
Deal found 3/2$455
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/139:03 am
MEM
-
FLO
1 stop5h 47m
American Airlines
Wed 5/205:20 am
FLO
-
MEM
1 stop3h 58m
American Airlines
Deal found 3/4$497
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:47 am
MEM
-
FLO
2 stops9h 03m
American Airlines
Tue 5/194:02 pm
FLO
-
MEM
1 stop4h 04m
American Airlines
Deal found 3/4$502
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/149:03 am
MEM
-
FLO
1 stop5h 47m
American Airlines
Tue 5/194:02 pm
FLO
-
MEM
1 stop4h 04m
American Airlines
Deal found 3/4$521
This American Airlines deal was found by Cheapflights users on 3/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/1810:59 am
MEM
-
FLO
1 stop5h 51m
American Airlines
Sun 3/226:20 pm
FLO
-
MEM
1 stop6h 31m
American Airlines
Deal found 3/3$522
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/139:03 am
MEM
-
FLO
1 stop5h 47m
American Airlines
Thu 5/212:35 pm
FLO
-
MEM
1 stop4h 44m
American Airlines
Deal found 3/4$541
This American Airlines deal was found by Cheapflights users on 3/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/143:23 pm
MEM
-
FLO
1 stop5h 24m
American Airlines
Thu 5/215:05 am
FLO
-
MEM
1 stop6h 02m
American Airlines
Deal found 3/4$565

Find flight deals from Memphis to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Memphis (MEM) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 6, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$455
(American Airlines)

One-way from

$382
(American Airlines)
Provider with most accurate pricing for Memphis-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Memphis-Florence flights.
Search Deals
From Memphis to Florence
Search Deals
One-way flight from Memphis to Florence
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Memphis to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 6, 2026.
Use the filters below to find and compare flights from Memphis to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Fri 4/3

6:08 pm-11:57 pm

1 stop4h 49m

Florence

Mon 4/6

6:20 pm-11:51 pm

1 stop6h 31m

$455

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Wed 5/13

9:03 am-3:50 pm

1 stop5h 47m

Florence

Wed 5/20

5:20 am-8:18 am

1 stop3h 58m

$497
Quickest round-trip

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Thu 5/14

3:23 pm-9:47 pm

1 stop5h 24m

Florence

Wed 5/20

5:20 am-8:18 am

1 stop3h 58m

$521

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Fri 5/15

3:23 pm-9:47 pm

1 stop5h 24m

Florence

Wed 5/20

4:16 pm-7:47 pm

1 stop4h 31m

$521

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Wed 3/18

10:59 am-5:50 pm

1 stop5h 51m

Florence

Sun 3/22

6:20 pm-11:51 pm

1 stop6h 31m

$522

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Thu 5/14

5:47 am-3:50 pm

2 stops9h 03m

Florence

Thu 5/21

2:35 pm-11:59 pm

2 stops10h 24m

$650
Cheapest one-way
Quickest one-way

MemphisFlorence

MEM - FLO

MEMFLO

Memphis

Wed 3/11

6:08 pm-11:57 pm

1 stop4h 49m

$382

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/5

Sorted by cheapest first

Compare providers for flights from Memphis to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Memphis to Florence in March.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
ExpediaPrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Memphis-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Memphis-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Memphis-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Memphis-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Memphis-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Memphis to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Memphis with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Memphis to Florence

What is the cheapest month to book a flight from Memphis to Florence, South Carolina?

Currently, August is the cheapest month in which you can book a flight from Memphis to Florence, South Carolina (average of $113). Flying from Memphis to Florence, South Carolina in November is currently the most expensive (average of $296). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Memphis to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Memphis to Florence, South Carolina?

    For as low as $455, American Airlines can have you in Florence, South Carolina from Memphis in 4h 49m. Memphis and Florence, South Carolina are separated by a distance of 586 mi.

  • Can I find deals for flights from Memphis to Florence that include hotel bookings?

    Yes. In addition to deals on Memphis to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Memphis to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Memphis to Florence.

  • Can I find deals for business class flights from Memphis to Florence?

    Yes. Cheapflights offers flight deals from Memphis to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Memphis to Florence, South Carolina?

    Currently, August is the cheapest month in which you can book a flight from Memphis to Florence, South Carolina (average of $113). Flying from Memphis to Florence, South Carolina in November is currently the most expensive (average of $296). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

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