HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Florence

$378+ Cheap flights from Louisville to Florence, SC (SDF - FLO)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
SDF — FLO
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Louisville to Florence with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Louisville to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Louisville (SDF) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$378
(American Airlines)
Provider with most accurate pricing for Louisville Intl-Florence flight deals.
Search Deals
Provider most trusted by Cheapflights users for Louisville Intl-Florence flights.
Search Deals
From Louisville Intl to Florence
Search Deals

Find flight deals from Louisville to Florence

Cheapest flights from Louisville to Florence
Explore the most affordable flight options available from Louisville to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1211:09 amSDF - FLO
2 stops11h 44mAmerican Airlines
Wed 11/1910:29 amFLO - SDF
2 stops11h 00mAmerican Airlines
Deal found 10/15$378
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:05 amSDF - FLO
2 stops12h 49mAmerican Airlines
Tue 11/411:14 amFLO - SDF
2 stops10h 15mAmerican Airlines
Deal found 10/16$398
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/311:08 pmSDF - FLO
1 stop5h 46mAmerican Airlines
Sat 11/19:00 amFLO - SDF
1 stop6h 05mAmerican Airlines
Deal found 10/15$490
This American Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/147:13 pmSDF - FLO
1 stop3h 40mAmerican Airlines
Sun 11/166:32 pmFLO - SDF
1 stop5h 50mAmerican Airlines
Deal found 10/16$497
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/18:22 amSDF - FLO
1 stop5h 42mAmerican Airlines
Tue 11/46:15 amFLO - SDF
1 stop4h 30mAmerican Airlines
Deal found 10/15$499
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/311:08 pmSDF - FLO
1 stop5h 46mAmerican Airlines
Mon 11/35:35 pmFLO - SDF
1 stop4h 04mAmerican Airlines
Deal found 10/15$500
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/311:08 pmSDF - FLO
1 stop5h 46mAmerican Airlines
Thu 11/611:11 amFLO - SDF
2 stops10h 49mAmerican Airlines
Deal found 10/15$505

Cheapflights Fare Finder

 
Customize your flight search to find flights from Louisville to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Louisville to Florence that are best for you.

Fly from

Louisville

Fly to

Florence

Route

Depart

Return

Price

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Fri 10/31

6:05 am-6:54 pm

2 stops12h 49m

Florence

Tue 11/4

11:14 am-9:29 pm

2 stops10h 15m

$398

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Wed 11/12

7:13 pm-10:53 pm

1 stop3h 40m

Florence

Wed 11/19

6:15 am-10:45 am

1 stop4h 30m

$431

LouisvilleFlorence

SDF - FLO

SDFFLO

Louisville Intl

Tue 4/14

8:58 am-2:10 pm

1 stop5h 12m

Florence

Sat 4/18

5:13 am-10:36 am

1 stop5h 23m

$475

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/16

Compare providers for flights from Louisville to Florence

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Louisville to Florence in October.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Louisville-Florence, South Carolina flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Louisville-Florence, South Carolina flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Louisville-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Louisville-Florence, South Carolina flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Louisville-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Louisville to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Louisville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Louisville to Florence

What is the cheapest month to book a flight from Louisville to Florence, South Carolina?

Currently, October is the cheapest month in which you can book a flight from Louisville to Florence, South Carolina (average of $41). Flying from Louisville to Florence, South Carolina in December is currently the most expensive (average of $89). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Louisville to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Louisville to Florence, South Carolina?

    American Airlines can get you from Louisville to Florence, South Carolina in just under 12h 49m. Your travel time can differ by up to . Louisville and Florence, South Carolina are separated by a distance of 434 mi.

  • Can I find deals for flights from Louisville to Florence that include hotel bookings?

    Yes. In addition to deals on Louisville to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Louisville to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Louisville to Florence.

  • Can I find deals for business class flights from Louisville to Florence?

    Yes. Cheapflights offers flight deals from Louisville to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Louisville to Florence, South Carolina?

    Currently, October is the cheapest month in which you can book a flight from Louisville to Florence, South Carolina (average of $41). Flying from Louisville to Florence, South Carolina in December is currently the most expensive (average of $89). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter
Hartsville
Darlington

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Louisville to Florence

See prices for flight routes from nearby airports that may be better suited for you.
Nashville to Charlotte flights
Cincinnati to Charlotte flights
Nashville to Savannah flights
Nashville to Charleston flights
Cincinnati to Savannah flights
Cincinnati to Myrtle Beach flights
Louisville to Charlotte flights
Cincinnati to Charleston flights
Nashville to Myrtle Beach flights
Louisville to Charleston flights
Nashville to Columbia flights
Nashville to Greenville flights
Cincinnati to Columbia flights
Knoxville to Myrtle Beach flights
Lexington to Charlotte flights
Cincinnati to Greenville flights
Louisville to Savannah flights
Louisville to Columbia flights
Louisville to Myrtle Beach flights
Lexington to Charleston flights
Lexington to Savannah flights
Knoxville to Charleston flights
Cincinnati to Hilton Head Island flights
Knoxville to Charlotte flights
Evansville to Charlotte flights
Lexington to Myrtle Beach flights
Lexington to Greenville flights
Louisville to Greenville flights
Louisville to Hilton Head Island flights
Cincinnati to Augusta flights
Knoxville to Savannah flights
Lexington to Hilton Head Island flights
Nashville to Augusta flights
Evansville to Charleston flights
Lexington to Columbia flights
Evansville to Savannah flights
Knoxville to Columbia flights
Knoxville to Hilton Head Island flights
Louisville to Augusta flights
Huntington to Charlotte flights
Nashville to Hilton Head Island flights
Lexington to Augusta flights
Huntington to Myrtle Beach flights
Blountville to Charlotte flights
Nashville to Florence flights
Blountville to Myrtle Beach flights
Cincinnati to Florence flights
Huntington to Augusta flights
Lexington to Florence flights

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.