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Des Moines

$88+ Cheap flights from Ohio to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/20. Fares are subject to change and may not be available on all flights or dates of travel.
CVG — DSM
Jan 21 — Jan 281
Wed 1/21
Wed 1/28
1 adult, Economy
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Cheap flight deals from Ohio to Des Moines

Cheapest flights from Ohio to Des Moines
Explore the most affordable flight options available from Ohio to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 22, 2025.

This American Airlines deal was found by Cheapflights users on 12/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/227:46 pmCAK - DSM
1 stop5h 51mAmerican Airlines
Mon 1/52:07 pmDSM - CAK
1 stop7h 05mAmerican Airlines
Deal found 12/22$324
This American Airlines deal was found by Cheapflights users on 12/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/266:59 amDAY - DSM
1 stop7h 22mAmerican Airlines
Mon 12/296:52 pmDSM - DAY
1 stop3h 58mAmerican Airlines
Deal found 12/19$339
This Delta deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:58 pmCLE - DSM
1 stop3h 46mDelta
Wed 12/315:55 pmDSM - CLE
1 stop5h 00mDelta
Deal found 12/21$416
This American Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:30 amCLE - DSM
2 stops8h 33mAmerican Airlines
Wed 12/312:07 pmDSM - CLE
1 stop6h 52mAmerican Airlines
Deal found 12/21$456
This Kiwi.com deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:00 pmCLE - DSM
1 stop18h 00mMultiple Airlines
Mon 1/58:29 pmDSM - CLE
1 stop13h 38mMultiple Airlines
Deal found 12/20$464
This Delta deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/307:32 amCVG - DSM
1 stop7h 06mDelta
Fri 1/26:30 pmDSM - CVG
1 stop4h 54mDelta
Deal found 12/20$507
This Southwest deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/274:40 pmCLE - DSM
2 stops8h 15mSouthwest
Mon 1/55:45 amDSM - CLE
2 stops8h 55mSouthwest
Deal found 12/20$534
This American Airlines deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/308:38 amCVG - DSM
1 stop5h 25mAmerican Airlines
Fri 1/23:27 pmDSM - CVG
2 stops7h 24mAmerican Airlines
Deal found 12/20$572
This Kiwi.com deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/253:39 pmDTW - DSM
1 stop23h 21mMultiple Airlines
Sun 12/289:31 amDSM - DTW
1 stop28h 03mMultiple Airlines
Deal found 12/20$596
This Kiwi.com deal was found by Cheapflights users on 12/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:56 pmPIT - DSM
1 stop21h 25mMultiple Airlines
Sun 12/287:30 pmDSM - PIT
1 stop13h 28mMultiple Airlines
Deal found 12/20$600
This Delta deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/234:50 pmDTW - DSM
Nonstop1h 58mDelta
Sun 12/286:15 amDSM - DTW
Nonstop1h 52mDelta
Deal found 12/21$619
This United Airlines deal was found by Cheapflights users on 12/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/239:12 amDTW - DSM
2 stops12h 18mUnited Airlines
Sun 12/283:14 pmDSM - DTW
1 stop6h 16mUnited Airlines
Deal found 12/21$644

Find flight deals from Ohio to Des Moines

Keep the following information in mind while searching for Ohio to Des Moines flight deals. Data was last updated December 22, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$222
(Kiwi.com)

One-way from

$88
(Kiwi.com)

Popular in

January

Cheapest in

November

Average price

$477
Provider with most accurate pricing for Cleveland Hopkins Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Cleveland Hopkins Intl-Des Moines flights.
Search Deals
From Ohio to Des Moines
Search Deals
One-way flight from Ohio to Des Moines
Search Deals
Highest demand for flights based on searches. 30% potential increase in price ($176 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($29 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Ohio to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 22, 2025.
Use the filters below to find and compare flights from Ohio to Des Moines that are best for you.

Fly from

Ohio

Fly to

Des Moines

Route

Depart

Return

Price

CincinnatiDes Moines

CVG - DSM

CVGDSM

Cincinnati Cinci./N. Kentucky

Mon 1/19

6:55 am-7:23 pm

1 stop13h 28m

Des Moines

Mon 1/26

8:30 am-11:58 pm

1 stop14h 28m

$222

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Thu 1/8

6:45 am-10:46 pm

1 stop17h 01m

Des Moines

Sat 1/17

5:58 pm-11:04 am

2 stops40h 06m

$251

PittsburghDes Moines

PIT - DSM

PITDSM

Pittsburgh

Fri 1/23

3:38 pm-10:17 pm

1 stop7h 39m

Des Moines

Sun 1/25

2:58 pm-9:40 am

1 stop17h 42m

$270

CincinnatiDes Moines

CVG - DSM

CVGDSM

Cincinnati Cinci./N. Kentucky

Thu 2/5

1:22 pm-9:21 pm

2 stops32h 59m

Des Moines

Thu 2/12

7:32 pm-11:42 pm

1 stop27h 10m

$272

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Thu 1/8

10:40 am-10:46 pm

1 stop13h 06m

Des Moines

Sun 1/11

2:58 pm-9:40 am

1 stop17h 42m

$274

ClevelandDes Moines

CLE - DSM

CLEDSM

Cleveland Hopkins Intl

Mon 1/5

5:30 am-2:58 pm

1 stop10h 28m

Des Moines

Fri 1/9

2:08 pm-12:46 am

1 stop9h 38m

$303

DetroitDes Moines

DTW - DSM

DTWDSM

Detroit Metropolitan Wayne County

Fri 1/9

10:43 am-9:21 pm

1 stop11h 38m

Des Moines

Mon 1/12

2:08 pm-11:55 pm

1 stop8h 47m

$305

DaytonDes Moines

DAY - DSM

DAYDSM

Dayton

Thu 1/1

5:21 pm-9:40 pm

1 stop5h 19m

Des Moines

Mon 1/5

6:46 pm-11:44 pm

1 stop3h 58m

$308

DaytonDes Moines

DAY - DSM

DAYDSM

Dayton

Thu 1/1

8:59 am-12:54 pm

1 stop4h 55m

Des Moines

Mon 1/5

3:27 pm-10:21 pm

1 stop5h 54m

$308

ColumbusDes Moines

CMH - DSM

CMHDSM

Columbus

Tue 1/20

6:00 am-2:33 pm

2 stops9h 33m

Des Moines

Sun 2/15

8:00 am-1:15 pm

1 stop4h 15m

$317

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/22

Showing 1-10 of 59 results
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Best time to book a flight from Ohio to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Ohio with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Ohio to Des Moines

What is the cheapest month to book a flight from Ohio to Des Moines?

Currently, April is the cheapest month in which you can book a flight from Ohio to Des Moines (average of $143). Flying from Ohio to Des Moines in January is currently the most expensive (average of $299). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from OH to DSM?

Find hourly flight availability from Ohio to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 22, 2025.

It’s typically best to fly out from Ohio to Des Moines in the evening. Doing so could potentially save you 25% on the flight price compared to flying at noon, which is usually more expensive.

What is the cheapest day to fly from Ohio to Des Moines?

Use this chart to determine the cheapest time to fly round-trip from Ohio to Des Moines. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Ohio to Des Moines flight should consider departing on Saturday evenings when fares are most often at their lowest. Monday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Ohio to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Ohio?

    If you book a flight to Des Moines from Ohio, you will be flying to Des Moines, which is the city’s only airport. Des Moines (DSM) is located 3.6 mi from the center of Des Moines.

  • How long is the flight from Ohio to Des Moines?

    There are many flights that can get you from Ohio to Des Moines in 4h 11m. Fly via United Airlines, American Airlines, or Delta to get the fastest option. The distance between Ohio and Des Moines is about 610 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Ohio to Des Moines one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $118. Delta flights start at $121 while deals on United Airlines start at $127 one-way.

  • What are the most popular routes from Ohio to Des Moines?

    While some choose either Detroit Metropolitan Wayne County - Des Moines or Columbus - Des Moines, Cleveland Hopkins Intl - Des Moines is the most popular route from Ohio to Des Moines.

  • Can I find deals for flights from Ohio to Des Moines that include hotel bookings?

    Yes. In addition to deals on Ohio to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Ohio to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Ohio to Des Moines.

  • Can I find deals for business class flights from Ohio to Des Moines?

    Yes. Cheapflights offers flight deals from Ohio to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Ohio to Des Moines?

    Currently, April is the cheapest month in which you can book a flight from Ohio to Des Moines (average of $143). Flying from Ohio to Des Moines in January is currently the most expensive (average of $299). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Alternative routes for Ohio to Des Moines

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Top 4 airlines flying from Ohio to Des Moines

Discover the top 4 airlines that operate flights from Ohio to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 22, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$163Average$362FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$236Average$373FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$243Average$375FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$286Average$391FlexibilityNo cancel feeOn-time63%

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