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Des Moines

$108+ Cheap flights from North Carolina to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/11. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — DSM
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from North Carolina to Des Moines

Keep the following information in mind while searching for North Carolina to Des Moines flight deals. Data was last updated September 15, 2025.

Round-trip from

$212
(Kiwi.com)

One-way from

$108
(Kiwi.com)

Popular in

June

Cheapest in

August

Average price

$429

Good round-trip deal

$349 or less

Good one-way deal

$295 or less
From North Carolina to Des Moines
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One-way flight from North Carolina to Des Moines
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Highest demand for flights based on searches. 8% potential increase in price ($39 potential increase over avg. RT price).
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Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from North Carolina to Des Moines.
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Price to beat on a one-way flight from North Carolina to Des Moines.
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Find flight deals from North Carolina to Des Moines

Cheapest flights from North Carolina to Des Moines
Explore the most affordable flight options available from North Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/610:11 pmCLT - DSM
1 stop13h 24mMultiple Airlines
Sun 11/99:03 pmDSM - CLT
1 stop18h 24mMultiple Airlines
Deal found 9/14$212
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/136:07 pmCLT - DSM
1 stop20h 42mMultiple Airlines
Sun 11/169:03 pmDSM - CLT
1 stop18h 24mMultiple Airlines
Deal found 9/14$225
This Frontier deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/1310:51 pmCLT - DSM
2 stops15h 58mFrontier
Sun 11/162:32 pmDSM - CLT
2 stops18h 40mFrontier
Deal found 9/14$240
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/125:33 pmRDU - DSM
1 stop7h 12mAmerican Airlines
Tue 1/63:30 pmDSM - RDU
1 stop7h 49mAmerican Airlines
Deal found 9/13$240
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/287:00 amTYS - DSM
1 stop7h 40mMultiple Airlines
Thu 10/26:30 amDSM - TYS
1 stop9h 14mMultiple Airlines
Deal found 9/12$247
This Delta deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:30 amRDU - DSM
1 stop5h 10mDelta
Mon 12/84:59 pmDSM - RDU
1 stop6h 00mDelta
Deal found 9/12$249
This American Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/58:30 amGSO - DSM
1 stop7h 01mAmerican Airlines
Mon 11/102:19 pmDSM - GSO
1 stop6h 25mAmerican Airlines
Deal found 9/13$249
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/152:14 pmRDU - DSM
2 stops20h 46mMultiple Airlines
Sun 11/162:32 pmDSM - RDU
1 stop25h 04mMultiple Airlines
Deal found 9/13$251
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/306:00 amILM - DSM
1 stop5h 05mDelta
Sun 11/27:20 amDSM - ILM
1 stop8h 03mDelta
Deal found 9/14$259
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/305:48 amAVL - DSM
1 stop5h 42mDelta
Sat 10/47:00 amDSM - AVL
1 stop5h 30mDelta
Deal found 9/15$259
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/309:06 amRDU - DSM
1 stop5h 55mMultiple Airlines
Sun 11/28:47 pmDSM - RDU
2 stops35h 46mMultiple Airlines
Deal found 9/14$259
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:35 amGSO - DSM
1 stop4h 57mUnited Airlines
Sat 10/411:31 amDSM - GSO
1 stop4h 16mUnited Airlines
Deal found 9/15$259

Cheapflights Fare Finder

 
Customize your flight search to find flights from North Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from North Carolina to Des Moines that are best for you.

Fly from

North Carolina

Fly to

Des Moines

Route

Depart

Return

Price

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Sun 9/28

7:00 am-1:40 pm

1 stop7h 40m

Des Moines

Thu 10/2

6:30 am-4:44 pm

1 stop9h 14m

$247

GreensboroDes Moines

GSO - DSM

GSODSM

Greensboro/H. Point

Wed 11/5

8:30 am-2:31 pm

1 stop7h 01m

Des Moines

Mon 11/10

2:19 pm-9:44 pm

1 stop6h 25m

$249

CharlotteDes Moines

CLT - DSM

CLTDSM

Charlotte Douglas

Thu 11/13

10:42 pm-1:49 pm

2 stops16h 07m

Des Moines

Sun 11/16

9:03 pm-4:27 pm

1 stop18h 24m

$249

WilmingtonDes Moines

ILM - DSM

ILMDSM

Wilmington New Hanover County

Thu 10/30

6:00 am-10:05 am

1 stop5h 05m

Des Moines

Sun 11/2

7:20 am-4:23 pm

1 stop8h 03m

$259

GreensboroDes Moines

GSO - DSM

GSODSM

Greensboro/H. Point

Tue 9/30

6:35 am-10:32 am

1 stop4h 57m

Des Moines

Sat 10/4

11:31 am-4:47 pm

1 stop4h 16m

$259

AshevilleDes Moines

AVL - DSM

AVLDSM

Asheville Regional

Tue 9/30

5:48 am-10:30 am

1 stop5h 42m

Des Moines

Sat 10/4

7:00 am-1:30 pm

1 stop5h 30m

$259

RaleighDes Moines

RDU - DSM

RDUDSM

Raleigh-Durham

Thu 10/30

9:06 am-2:01 pm

1 stop5h 55m

Des Moines

Sun 11/2

8:47 pm-9:33 am

2 stops35h 46m

$259

NorfolkDes Moines

ORF - DSM

ORFDSM

Norfolk

Wed 11/19

7:30 am-8:29 am

1 stop25h 59m

Des Moines

Sun 11/23

2:43 pm-4:12 pm

1 stop24h 29m

$269

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Fri 10/31

4:58 pm-11:42 pm

1 stop7h 44m

Des Moines

Tue 11/4

3:15 pm-8:33 pm

1 stop4h 18m

$271

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

Tue 10/14

7:00 am-12:19 pm

1 stop6h 19m

Des Moines

Sat 10/18

11:31 am-5:17 pm

1 stop4h 46m

$271

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 60 results
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Best time to book a flight from North Carolina to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from North Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from North Carolina to Des Moines

What is the cheapest month to book a flight from North Carolina to Des Moines?

Currently, August is the cheapest month in which you can book a flight from North Carolina to Des Moines (average of $336). Flying from North Carolina to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from NC to DSM?

Find hourly flight availability from North Carolina to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from North Carolina to Des Moines as you normally would.

Related info for your journey

Find useful and relevant information for your journey from North Carolina to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from North Carolina?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly into when you book flights from North Carolina to Des Moines.

  • How long is the flight from North Carolina to Des Moines?

    A quick flight from North Carolina to Des Moines can take about 4h 57m. American Airlines provides one of the quickest options available for as low as $259. Airlines will cover a distance of 827 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from North Carolina to Des Moines one-way?

    $108 is the cheapest one-way deal found within the past few days, from Frontier. You may also be able to find cheap deals on Allegiant Air and American Airlines, with prices starting from $140 and $149, respectively.

  • What are the most popular routes from North Carolina to Des Moines?

    When deciding which route to take from North Carolina to Des Moines consider Charlotte Douglas - Des Moines, Raleigh-Durham - Des Moines or Knoxville McGhee Tyson - Des Moines as they are the most popular.

  • Can I find deals for flights from North Carolina to Des Moines that include hotel bookings?

    Yes. In addition to deals on North Carolina to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from North Carolina to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from North Carolina to Des Moines.

  • Can I find deals for business class flights from North Carolina to Des Moines?

    Yes. Cheapflights offers flight deals from North Carolina to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from North Carolina to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from North Carolina to Des Moines (average of $336). Flying from North Carolina to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Alternative routes for North Carolina to Des Moines

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Top 4 airlines flying from North Carolina to Des Moines

Discover the top 4 airlines that operate flights from North Carolina to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$124Average$353FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$243Average$464FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$417FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$296Average$376FlexibilityNo cancel feeOn-time63%

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