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Des Moines

$72+ Cheap flights from North Carolina to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
RDU — DSM
nov. 16 — nov. 231
dom. 11/16
dom. 11/23
1 adult, Economy
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Find flight deals from North Carolina to Des Moines

Cheapest flights from North Carolina to Des Moines
Explore the most affordable flight options available from North Carolina to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 17, 2025.

This Mytrip deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/145:45 amCLT - DSM
1 stop10h 10mMultiple Airlines
lun. 11/178:40 amDSM - CLT
1 stop13h 28mMultiple Airlines
Deal found 10/16$215
This Mytrip deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/309:00 amTYS - DSM
1 stop6h 01mAllegiant Air
lun. 11/311:45 amDSM - TYS
1 stop6h 56mAllegiant Air
Deal found 10/15$226
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/145:45 amCLT - DSM
1 stop10h 10mMultiple Airlines
dom. 11/162:32 pmDSM - CLT
1 stop25h 45mMultiple Airlines
Deal found 10/16$234
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/309:39 pmRDU - DSM
1 stop18h 11mMultiple Airlines
dom. 11/27:30 amDSM - RDU
1 stop10h 42mMultiple Airlines
Deal found 10/16$242
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/309:06 amRDU - DSM
1 stop5h 55mMultiple Airlines
lun. 11/38:30 amDSM - RDU
2 stops31h 38mMultiple Airlines
Deal found 10/15$243
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 11/67:00 amTYS - DSM
1 stop7h 56mMultiple Airlines
lun. 11/108:00 amDSM - TYS
1 stop28h 01mMultiple Airlines
Deal found 10/16$249
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/178:52 amCLT - DSM
1 stop7h 06mMultiple Airlines
mié. 11/195:21 pmDSM - CLT
1 stop25h 36mMultiple Airlines
Deal found 10/16$255
This Mytrip deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/309:00 amTYS - DSM
1 stop6h 01mMultiple Airlines
lun. 11/31:43 pmDSM - TYS
2 stops19h 50mMultiple Airlines
Deal found 10/15$255
This American Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 11/77:43 pmILM - DSM
1 stop4h 47mAmerican Airlines
dom. 11/912:54 pmDSM - ILM
1 stop4h 59mAmerican Airlines
Deal found 10/15$259
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/305:42 amAVL - DSM
1 stop5h 23mDelta
lun. 11/36:39 pmDSM - AVL
1 stop4h 11mDelta
Deal found 10/15$259
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 10/316:30 amGSO - DSM
1 stop5h 00mUnited Airlines
mar. 11/43:15 pmDSM - GSO
1 stop4h 30mUnited Airlines
Deal found 10/15$259
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 10/305:42 amAVL - DSM
2 stops9h 17mDelta
dom. 11/26:39 pmDSM - AVL
1 stop4h 11mDelta
Deal found 10/15$264

Cheap flight deals from North Carolina to Des Moines

Keep the following information in mind while searching for North Carolina to Des Moines flight deals. Data was last updated octubre 17, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$215
(Mytrip)

One-way from

$72
(Kiwi.com)

Popular in

February

Cheapest in

August

Average price

$418

Good round-trip deal

$421 or less
Provider with most accurate pricing for Raleigh-Durham-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Raleigh-Durham-Des Moines flights.
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From North Carolina to Des Moines
Search Deals
One-way flight from North Carolina to Des Moines
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($15 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals
Price to beat on a round-trip flight from North Carolina to Des Moines.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from North Carolina to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 17, 2025.
Use the filters below to find and compare flights from North Carolina to Des Moines that are best for you.

Fly from

North Carolina

Fly to

Des Moines

Route

Depart

Return

Price

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

jue. 10/30

9:00 am-2:01 pm

1 stop6h 01m

Des Moines

lun. 11/3

11:45 am-7:41 pm

1 stop6h 56m

$226

RaleighDes Moines

RDU - DSM

RDUDSM

Raleigh-Durham

jue. 10/30

9:39 pm-2:50 pm

1 stop18h 11m

Des Moines

dom. 11/2

7:30 am-7:12 pm

1 stop10h 42m

$242

GreensboroDes Moines

GSO - DSM

GSODSM

Greensboro/H. Point

jue. 2/19

6:05 am-9:30 am

1 stop4h 25m

Des Moines

lun. 2/23

5:15 pm-11:53 pm

1 stop5h 38m

$249

AshevilleDes Moines

AVL - DSM

AVLDSM

Asheville Regional

mié. 4/1

7:45 am-4:56 pm

2 stops10h 11m

Des Moines

sáb. 4/4

5:45 am-11:00 am

1 stop4h 15m

$254

KnoxvilleDes Moines

TYS - DSM

TYSDSM

Knoxville McGhee Tyson

jue. 10/30

9:00 am-2:01 pm

1 stop6h 01m

Des Moines

lun. 11/3

1:43 pm-10:33 am

2 stops19h 50m

$255

WilmingtonDes Moines

ILM - DSM

ILMDSM

Wilmington New Hanover County

vie. 11/7

7:43 pm-11:30 pm

1 stop4h 47m

Des Moines

dom. 11/9

12:54 pm-6:53 pm

1 stop4h 59m

$259

GreensboroDes Moines

GSO - DSM

GSODSM

Greensboro/H. Point

vie. 10/31

6:30 am-10:30 am

1 stop5h 00m

Des Moines

mar. 11/4

3:15 pm-8:45 pm

1 stop4h 30m

$259

WilmingtonDes Moines

ILM - DSM

ILMDSM

Wilmington New Hanover County

jue. 2/19

12:15 pm-8:03 pm

1 stop8h 48m

Des Moines

lun. 2/23

5:15 pm-11:54 pm

1 stop5h 39m

$259

AshevilleDes Moines

AVL - DSM

AVLDSM

Asheville Regional

jue. 10/30

5:42 am-10:05 am

1 stop5h 23m

Des Moines

lun. 11/3

6:39 pm-11:50 pm

1 stop4h 11m

$259

AshevilleDes Moines

AVL - DSM

AVLDSM

Asheville Regional

mié. 10/29

5:42 am-10:05 am

1 stop5h 23m

Des Moines

dom. 11/2

6:39 pm-11:50 pm

1 stop4h 11m

$259

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/16

Showing 1-10 of 60 results
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Best time to book a flight from North Carolina to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from North Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from North Carolina to Des Moines

What is the cheapest month to book a flight from North Carolina to Des Moines?

Currently, November is the cheapest month in which you can book a flight from North Carolina to Des Moines (average of $157). Flying from North Carolina to Des Moines in December is currently the most expensive (average of $259). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from NC to DSM?

Find hourly flight availability from North Carolina to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated octubre 17, 2025.

It’s typically best to fly out from North Carolina to Des Moines in the evening. Doing so could potentially save you 14% on the flight price compared to flying in the morning, which is usually more expensive.

What is the cheapest day to fly from North Carolina to Des Moines?

Use this chart to determine the cheapest time to fly round-trip from North Carolina to Des Moines. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their North Carolina to Des Moines flight should consider departing on Monday afternoons when fares are most often at their lowest. Monday at noon flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from North Carolina to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from North Carolina?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly into when you book flights from North Carolina to Des Moines.

  • How long is the flight from North Carolina to Des Moines?

    A quick flight from North Carolina to Des Moines can take about 4h 25m. Allegiant Air provides one of the quickest options available for as low as $249. Airlines will cover a distance of 827 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the most popular routes from North Carolina to Des Moines?

    When deciding which route to take from North Carolina to Des Moines consider Charlotte Douglas - Des Moines, Raleigh-Durham - Des Moines or Asheville Regional - Des Moines as they are the most popular.

  • Can I find deals for flights from North Carolina to Des Moines that include hotel bookings?

    Yes. In addition to deals on North Carolina to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from North Carolina to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from North Carolina to Des Moines.

  • Can I find deals for business class flights from North Carolina to Des Moines?

    Yes. Cheapflights offers flight deals from North Carolina to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from North Carolina to Des Moines?

    Currently, November is the cheapest month in which you can book a flight from North Carolina to Des Moines (average of $157). Flying from North Carolina to Des Moines in December is currently the most expensive (average of $259). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Alternative routes for North Carolina to Des Moines

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Top 4 airlines flying from North Carolina to Des Moines

Discover the top 4 airlines that operate flights from North Carolina to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$232Average$348FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$242Average$444FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$248Average$412FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$296Average$376FlexibilityNo cancel feeOn-time63%

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