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Des Moines

$136+ Cheap flights from Mississippi to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/7. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — DSM
Feb 14 — Feb 211
Sat 2/14
Sat 2/21
1 adult, Economy
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Cheap flight deals from Mississippi to Des Moines

Keep the following information in mind while searching for Mississippi to Des Moines flight deals. Data was last updated January 15, 2026.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$269
(Delta)

One-way from

$136
(Delta)
Provider with most accurate pricing for Jackson-Evers Intl-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Jackson-Evers Intl-Des Moines flights.
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From Mississippi to Des Moines
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One-way flight from Mississippi to Des Moines
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Find flight deals from Mississippi to Des Moines

Cheapest flights from Mississippi to Des Moines
Explore the most affordable flight options available from Mississippi to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 15, 2026.

This Delta deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/96:07 am
BTR
-
DSM
1 stop4h 41m
Delta
Fri 5/85:45 am
DSM
-
BTR
1 stop7h 02m
Delta
Deal found 1/13$269
This Delta deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/286:00 am
MEM
-
DSM
1 stop4h 17m
Delta
Sat 3/712:28 pm
DSM
-
MEM
1 stop5h 27m
Delta
Deal found 1/14$270
This Delta deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:07 am
BTR
-
DSM
2 stops9h 35m
Delta
Fri 5/85:45 am
DSM
-
BTR
1 stop7h 02m
Delta
Deal found 1/13$274
This Delta deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:07 am
BTR
-
DSM
2 stops9h 35m
Delta
Sat 5/97:00 am
DSM
-
BTR
2 stops7h 47m
Delta
Deal found 1/13$280
This Delta deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/136:00 am
MEM
-
DSM
1 stop4h 17m
Delta
Wed 2/186:19 am
DSM
-
MEM
1 stop5h 06m
Delta
Deal found 1/14$299
This Delta deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:18 am
BTR
-
DSM
1 stop4h 43m
Delta
Fri 5/85:45 am
DSM
-
BTR
1 stop7h 02m
Delta
Deal found 1/13$304
This Delta deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:00 am
MOB
-
DSM
1 stop5h 01m
Delta
Sun 3/86:15 am
DSM
-
MOB
2 stops9h 06m
Delta
Deal found 1/14$309
This Delta deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:18 am
BTR
-
DSM
2 stops9h 22m
Delta
Wed 5/65:45 am
DSM
-
BTR
1 stop7h 02m
Delta
Deal found 1/13$309
This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/147:30 am
MEM
-
DSM
1 stop6h 57m
United Airlines
Wed 2/187:52 am
DSM
-
MEM
1 stop8h 16m
United Airlines
Deal found 1/13$311
This Delta deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/66:18 am
BTR
-
DSM
2 stops9h 22m
Delta
Tue 5/510:34 am
DSM
-
BTR
2 stops7h 50m
Delta
Deal found 1/13$315
This United Airlines deal was found by Cheapflights users on 1/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/23:00 pm
MEM
-
DSM
1 stop5h 56m
United Airlines
Sat 6/66:15 am
DSM
-
MEM
1 stop4h 17m
United Airlines
Deal found 1/15$317
This Delta deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/106:07 am
BTR
-
DSM
2 stops9h 35m
Delta
Wed 5/66:10 am
DSM
-
BTR
2 stops8h 57m
Delta
Deal found 1/13$325

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
Use the filters below to find and compare flights from Mississippi to Des Moines that are best for you.

Fly from

Mississippi

Fly to

Des Moines

Route

Depart

Return

Price

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Wed 3/11

6:07 am-10:48 am

1 stop4h 41m

Des Moines

Sun 5/10

5:45 am-12:47 pm

1 stop7h 02m

$269

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Wed 3/11

6:07 am-10:48 am

1 stop4h 41m

Des Moines

Tue 5/5

5:15 pm-10:01 pm

1 stop4h 46m

$269

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Wed 3/11

6:07 am-10:48 am

1 stop4h 41m

Des Moines

Wed 5/6

5:45 am-12:47 pm

1 stop7h 02m

$269

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Tue 3/10

4:00 pm-10:38 pm

1 stop6h 38m

Des Moines

Mon 5/4

5:15 pm-10:01 pm

1 stop4h 46m

$269

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Tue 3/10

4:00 pm-10:38 pm

1 stop6h 38m

Des Moines

Sat 5/2

5:45 am-12:47 pm

1 stop7h 02m

$269

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Tue 3/10

6:07 am-10:48 am

1 stop4h 41m

Des Moines

Sat 5/9

5:45 am-12:47 pm

1 stop7h 02m

$269

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Tue 3/10

4:00 pm-10:38 pm

1 stop6h 38m

Des Moines

Fri 5/8

5:45 am-12:47 pm

1 stop7h 02m

$269

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Thu 3/12

10:26 am-4:33 pm

1 stop6h 07m

Des Moines

Sat 5/9

5:45 am-12:47 pm

1 stop7h 02m

$269

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sat 2/28

6:00 am-10:17 am

1 stop4h 17m

Des Moines

Sat 3/7

12:28 pm-5:55 pm

1 stop5h 27m

$270

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Mon 3/9

6:07 am-10:48 am

1 stop4h 41m

Des Moines

Sat 5/9

7:00 am-2:47 pm

2 stops7h 47m

$274

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/13

Showing 1-10 of 40 results
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Best time to book a flight from Mississippi to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Des Moines
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mississippi?

    Des Moines (DSM) is the airport you will fly into if you book a flight from Mississippi to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • How long is the flight from Mississippi to Des Moines?

    Departing from Mississippi to Des Moines will take you 4h 41m. There are 773 mi between Mississippi and Des Moines. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Mississippi to Des Moines?

    The most popular flight routes from Mississippi to Des Moines are Memphis - Des Moines, Baton Rouge Ryan - Des Moines and Laurel Hattiesburg-PineBelt - Des Moines.

  • Can I find deals for flights from Mississippi to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mississippi to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Des Moines.

  • Can I find deals for business class flights from Mississippi to Des Moines?

    Yes. Cheapflights offers flight deals from Mississippi to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Alternative routes for Mississippi to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Mississippi to Des Moines

Discover the top airline that operate flights from Mississippi to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$124Average$254FlexibilityNo cancel feeOn-timeN/A

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