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Des Moines

$145+ Cheap flights from Mississippi to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/13. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — DSM
Mar 5 — Mar 121
Thu 3/5
Thu 3/12
1 adult, Economy
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Cheap flight deals from Mississippi to Des Moines

Cheapest flights from Mississippi to Des Moines
Explore the most affordable flight options available from Mississippi to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.

This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/196:00 pm
GPT
-
DSM
1 stop4h 28m
Delta
Sun 2/225:15 pm
DSM
-
GPT
1 stop4h 39m
Delta
Deal found 2/2$279
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/266:00 am
MEM
-
DSM
1 stop5h 01m
Delta
Sat 2/2812:28 pm
DSM
-
MEM
1 stop5h 27m
Delta
Deal found 2/2$299
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/116:07 am
BTR
-
DSM
1 stop4h 41m
Delta
Mon 5/115:29 am
DSM
-
BTR
1 stop7h 20m
Delta
Deal found 2/2$304
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/215:55 pm
MEM
-
DSM
1 stop4h 31m
Delta
Wed 8/192:15 pm
DSM
-
MEM
1 stop6h 13m
Delta
Deal found 2/2$307
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/216:00 am
MEM
-
DSM
1 stop4h 15m
Delta
Sun 8/165:45 am
DSM
-
MEM
1 stop6h 52m
Delta
Deal found 2/2$317
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/205:55 pm
MEM
-
DSM
1 stop4h 31m
Delta
Tue 8/185:35 pm
DSM
-
MEM
1 stop4h 49m
Delta
Deal found 2/2$318
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/196:00 am
MEM
-
DSM
1 stop4h 15m
Delta
Thu 8/202:15 pm
DSM
-
MEM
1 stop6h 13m
Delta
Deal found 2/2$327
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/205:55 pm
MEM
-
DSM
1 stop4h 31m
Delta
Sun 8/165:45 am
DSM
-
MEM
1 stop6h 52m
Delta
Deal found 2/2$328
This Southwest deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/2112:25 pm
MEM
-
DSM
2 stops9h 15m
Southwest
Tue 8/186:10 am
DSM
-
MEM
1 stop5h 35m
Southwest
Deal found 2/2$332
This United Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/248:17 am
MEI
-
DSM
2 stops11h 50m
United Airlines
Sat 2/288:00 am
DSM
-
MEI
2 stops10h 39m
United Airlines
Deal found 2/2$339
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:00 am
MEM
-
DSM
1 stop4h 15m
Delta
Wed 8/195:35 pm
DSM
-
MEM
1 stop4h 49m
Delta
Deal found 2/2$353
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:00 am
MEM
-
DSM
1 stop4h 15m
Delta
Tue 8/185:45 am
DSM
-
MEM
1 stop6h 52m
Delta
Deal found 2/2$354

Find flight deals from Mississippi to Des Moines

Keep the following information in mind while searching for Mississippi to Des Moines flight deals. Data was last updated February 3, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$279
(Delta)

One-way from

$145
(United Airlines)
Provider with most accurate pricing for Jackson-Evers Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Jackson-Evers Intl-Des Moines flights.
Search Deals
From Mississippi to Des Moines
Search Deals
One-way flight from Mississippi to Des Moines
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Mississippi to Des Moines that are best for you.

Fly from

Mississippi

Fly to

Des Moines

Route

Depart

Return

Price

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

Thu 2/19

6:00 pm-10:28 pm

1 stop4h 28m

Des Moines

Sun 2/22

5:15 pm-9:54 pm

1 stop4h 39m

$279

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Wed 3/11

6:07 am-10:48 am

1 stop4h 41m

Des Moines

Mon 5/11

5:29 am-12:49 pm

1 stop7h 20m

$304

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Tue 7/21

5:55 pm-10:26 pm

1 stop4h 31m

Des Moines

Wed 8/19

2:15 pm-8:28 pm

1 stop6h 13m

$307

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Wed 7/22

6:00 am-10:15 am

1 stop4h 15m

Des Moines

Tue 8/18

5:45 am-10:48 am

1 stop5h 03m

$307

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Wed 7/22

5:30 am-10:14 am

1 stop4h 44m

Des Moines

Wed 8/19

10:15 am-4:53 pm

1 stop6h 38m

$307

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Wed 6/10

7:15 am-12:30 pm

1 stop5h 15m

Des Moines

Sat 6/13

6:00 am-11:00 am

1 stop5h 00m

$317

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Wed 7/22

5:30 am-10:14 am

1 stop4h 44m

Des Moines

Mon 8/17

6:30 pm-10:48 pm

1 stop4h 18m

$317

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Tue 7/21

12:00 pm-5:42 pm

1 stop5h 42m

Des Moines

Thu 8/20

7:00 am-11:16 am

1 stop4h 16m

$317

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Wed 7/22

5:30 am-10:14 am

1 stop4h 44m

Des Moines

Sun 8/16

5:45 am-12:37 pm

1 stop6h 52m

$317

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Wed 7/22

5:30 am-10:14 am

1 stop4h 44m

Des Moines

Thu 8/20

5:45 am-12:37 pm

1 stop6h 52m

$317

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/1

Showing 1-10 of 50 results
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Best time to book a flight from Mississippi to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Des Moines
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mississippi?

    Des Moines (DSM) is the airport you will fly into if you book a flight from Mississippi to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • How long is the flight from Mississippi to Des Moines?

    Departing from Mississippi to Des Moines will take you 4h 28m. There are 810 mi between Mississippi and Des Moines. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Mississippi to Des Moines?

    The most popular flight routes from Mississippi to Des Moines are Baton Rouge Ryan - Des Moines, Gulfport Biloxi Regional - Des Moines and Memphis - Des Moines.

  • Can I find deals for flights from Mississippi to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mississippi to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Des Moines.

  • Can I find deals for business class flights from Mississippi to Des Moines?

    Yes. Cheapflights offers flight deals from Mississippi to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Mississippi to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Mississippi to Des Moines

Discover the top airline that operate flights from Mississippi to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$124Average$254FlexibilityNo cancel feeOn-timeN/A

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