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Des Moines

$126+ Cheap flights from Mississippi to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/7. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — DSM
Jan 30 — Feb 61
Fri 1/30
Fri 2/6
1 adult, Economy
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Cheap flight deals from Mississippi to Des Moines

Best flights from Mississippi to Des Moines
Discover carefully curated flight deals from Mississippi to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 31, 2025.

This American Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/185:30 amMEM - DSM
1 stop5h 20mAmerican Airlines
Wed 1/2111:42 amDSM - MEM
1 stop5h 33mAmerican Airlines
Deal found 12/30$240
This United Airlines deal was found by Cheapflights users on 12/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/264:15 pmMEM - DSM
1 stop7h 29mUnited Airlines
Mon 2/23:35 pmDSM - MEM
1 stop6h 24mUnited Airlines
Deal found 12/29$277
This Delta deal was found by Cheapflights users on 12/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/2710:26 amBTR - DSM
1 stop6h 07mDelta
Sun 3/295:35 amDSM - BTR
1 stop7h 16mDelta
Deal found 12/29$289
This American Airlines deal was found by Cheapflights users on 12/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/246:00 amMEM - DSM
1 stop6h 46mAmerican Airlines
Wed 1/285:01 pmDSM - MEM
1 stop6h 06mAmerican Airlines
Deal found 12/29$251
This United Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/163:30 pmBTR - DSM
1 stop7h 00mUnited Airlines
Sun 1/181:35 pmDSM - BTR
2 stops7h 57mUnited Airlines
Deal found 12/30$284
This American Airlines deal was found by Cheapflights users on 12/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/135:31 amGPT - DSM
1 stop5h 19mAmerican Airlines
Sat 1/175:00 pmDSM - GPT
1 stop6h 08mAmerican Airlines
Deal found 12/28$279
This United Airlines deal was found by Cheapflights users on 12/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/147:30 amMEM - DSM
1 stop6h 57mUnited Airlines
Wed 2/183:24 pmDSM - MEM
1 stop6h 35mUnited Airlines
Deal found 12/28$289
This American Airlines deal was found by Cheapflights users on 12/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/145:32 pmMOB - DSM
1 stop5h 36mAmerican Airlines
Sun 1/184:00 pmDSM - MOB
1 stop6h 59mAmerican Airlines
Deal found 12/29$279
This American Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/1610:33 amBTR - DSM
1 stop4h 42mAmerican Airlines
Sun 1/185:51 pmDSM - BTR
1 stop5h 05mAmerican Airlines
Deal found 12/30$279
This United Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/259:55 amMEM - DSM
1 stop4h 38mUnited Airlines
Mon 2/23:35 pmDSM - MEM
1 stop6h 24mUnited Airlines
Deal found 12/30$312
This American Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/155:31 pmBTR - DSM
1 stop5h 37mAmerican Airlines
Mon 1/195:51 pmDSM - BTR
1 stop5h 05mAmerican Airlines
Deal found 12/30$279
This United Airlines deal was found by Cheapflights users on 12/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/214:50 pmMOB - DSM
1 stop5h 40mUnited Airlines
Sat 1/248:10 amDSM - MOB
1 stop7h 59mUnited Airlines
Deal found 12/28$339
This American Airlines deal was found by Cheapflights users on 12/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 1/263:58 pmMEM - DSM
1 stop7h 10mAmerican Airlines
Mon 2/211:42 amDSM - MEM
2 stops8h 50mAmerican Airlines
Deal found 12/29$282
This Delta deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/279:48 amGPT - DSM
2 stops10h 57mDelta
Sun 3/295:20 pmDSM - GPT
1 stop4h 55mDelta
Deal found 12/31$513
This United Airlines deal was found by Cheapflights users on 12/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/248:17 amMEI - DSM
1 stop6h 00mUnited Airlines
Sat 2/282:59 pmDSM - MEI
1 stop21h 16mUnited Airlines
Deal found 12/28$405
This United Airlines deal was found by Cheapflights users on 12/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/1412:14 pmBTR - DSM
2 stops9h 27mUnited Airlines
Wed 2/187:52 amDSM - BTR
1 stop5h 26mUnited Airlines
Deal found 12/28$414
This United Airlines deal was found by Cheapflights users on 12/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/43:21 pmPIB - DSM
1 stop7h 09mUnited Airlines
Sat 2/73:04 pmDSM - PIB
1 stop23h 20mUnited Airlines
Deal found 12/28$415
This United Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/134:42 pmGPT - DSM
1 stop5h 48mUnited Airlines
Sat 1/179:03 amDSM - GPT
2 stops10h 45mUnited Airlines
Deal found 12/30$458
This United Airlines deal was found by Cheapflights users on 12/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/281:58 pmGPT - DSM
2 stops24h 29mUnited Airlines
Tue 3/37:52 amDSM - GPT
1 stop5h 28mUnited Airlines
Deal found 12/28$533

Find flight deals from Mississippi to Des Moines

Keep the following information in mind while searching for Mississippi to Des Moines flight deals. Data was last updated December 31, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$240
(American Airlines)

One-way from

$126
(American Airlines)
Provider with most accurate pricing for Jackson-Evers Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Jackson-Evers Intl-Des Moines flights.
Search Deals
From Mississippi to Des Moines
Search Deals
One-way flight from Mississippi to Des Moines
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 31, 2025.
Use the filters below to find and compare flights from Mississippi to Des Moines that are best for you.

Fly from

Mississippi

Fly to

Des Moines

Route

Depart

Return

Price

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sun 1/18

5:30 am-10:50 am

1 stop5h 20m

Des Moines

Wed 1/21

11:42 am-5:15 pm

1 stop5h 33m

$240

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sat 1/24

6:00 am-12:46 pm

1 stop6h 46m

Des Moines

Wed 1/28

5:01 pm-11:07 pm

1 stop6h 06m

$251

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Mon 1/26

4:15 pm-11:44 pm

1 stop7h 29m

Des Moines

Mon 2/2

3:35 pm-9:59 pm

1 stop6h 24m

$277

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

Tue 1/13

5:31 am-10:50 am

1 stop5h 19m

Des Moines

Sat 1/17

5:00 pm-11:08 pm

1 stop6h 08m

$279

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Wed 1/14

5:32 pm-11:08 pm

1 stop5h 36m

Des Moines

Sun 1/18

4:00 pm-10:59 pm

1 stop6h 59m

$279

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Fri 1/16

10:33 am-3:15 pm

1 stop4h 42m

Des Moines

Sun 1/18

5:51 pm-10:56 pm

1 stop5h 05m

$279

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Thu 1/15

5:31 pm-11:08 pm

1 stop5h 37m

Des Moines

Mon 1/19

5:51 pm-10:56 pm

1 stop5h 05m

$279

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Mon 1/26

3:58 pm-11:08 pm

1 stop7h 10m

Des Moines

Mon 2/2

11:42 am-8:32 pm

2 stops8h 50m

$282

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Fri 1/16

3:30 pm-10:30 pm

1 stop7h 00m

Des Moines

Sun 1/18

1:35 pm-9:32 pm

2 stops7h 57m

$284

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Fri 3/27

10:26 am-4:33 pm

1 stop6h 07m

Des Moines

Sun 3/29

5:35 am-12:51 pm

1 stop7h 16m

$289

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/29

Showing 1-10 of 29 results
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Best time to book a flight from Mississippi to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Des Moines
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mississippi?

    Des Moines (DSM) is the airport you will fly into if you book a flight from Mississippi to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • How long is the flight from Mississippi to Des Moines?

    Departing from Mississippi to Des Moines will take you 5h 20m. There are 491 mi between Mississippi and Des Moines. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Mississippi to Des Moines?

    The most popular flight routes from Mississippi to Des Moines are Memphis - Des Moines, Baton Rouge Ryan - Des Moines and Gulfport Biloxi Regional - Des Moines.

  • Can I find deals for flights from Mississippi to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mississippi to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Des Moines.

  • Can I find deals for business class flights from Mississippi to Des Moines?

    Yes. Cheapflights offers flight deals from Mississippi to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Johnston
Boone
Ames
Clive
West Des Moines
Ankeny

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Alternative routes for Mississippi to Des Moines

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Top airline flying from Mississippi to Des Moines

Discover the top airline that operate flights from Mississippi to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 31, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$124Average$254FlexibilityNo cancel feeOn-timeN/A

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