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Des Moines

$96+ Cheap flights from Mississippi to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/7. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — DSM
Jan 2 — Jan 91
Fri 1/2
Fri 1/9
1 adult, Economy
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Cheap flight deals from Mississippi to Des Moines

Cheapest flights from Mississippi to Des Moines
Explore the most affordable flight options available from Mississippi to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 3, 2025.

This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/305:28 pmMEM - DSM
1 stop6h 18mAmerican Airlines
Tue 1/65:51 pmDSM - MEM
1 stop5h 00mAmerican Airlines
Deal found 12/2$253
This United Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/2411:25 amMEM - DSM
1 stop7h 56mUnited Airlines
Fri 1/23:14 pmDSM - MEM
1 stop6h 44mUnited Airlines
Deal found 12/1$289
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/245:12 amMEM - DSM
1 stop5h 35mAmerican Airlines
Fri 1/23:27 pmDSM - MEM
2 stops8h 29mAmerican Airlines
Deal found 12/1$294
This American Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/315:00 amMEM - DSM
2 stops9h 52mAmerican Airlines
Wed 1/711:42 amDSM - MEM
2 stops8h 50mAmerican Airlines
Deal found 12/3$299
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/185:58 pmGPT - DSM
1 stop5h 37mAmerican Airlines
Mon 12/221:18 pmDSM - GPT
2 stops10h 54mAmerican Airlines
Deal found 12/2$314
This American Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/294:34 pmBTR - DSM
1 stop8h 03mAmerican Airlines
Mon 1/55:39 pmDSM - BTR
1 stop4h 39mAmerican Airlines
Deal found 12/3$328
This Delta deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1612:48 pmMEM - DSM
1 stop4h 59mDelta
Sat 12/206:30 pmDSM - MEM
1 stop4h 41mDelta
Deal found 12/2$329
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1610:29 amMEM - DSM
2 stops8h 06mAmerican Airlines
Sat 12/201:56 pmDSM - MEM
1 stop5h 43mAmerican Airlines
Deal found 12/2$334
This United Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/223:13 pmMEM - DSM
1 stop5h 17mUnited Airlines
Fri 1/23:14 pmDSM - MEM
1 stop6h 44mUnited Airlines
Deal found 12/1$337
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:12 amMEM - DSM
1 stop5h 35mAmerican Airlines
Fri 1/23:27 pmDSM - MEM
2 stops8h 29mAmerican Airlines
Deal found 12/1$342
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/184:28 pmBTR - DSM
1 stop7h 07mAmerican Airlines
Thu 1/111:32 amDSM - BTR
1 stop5h 51mAmerican Airlines
Deal found 12/2$343
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:12 amMEM - DSM
1 stop5h 35mAmerican Airlines
Mon 12/296:52 pmDSM - MEM
1 stop5h 07mAmerican Airlines
Deal found 12/1$347

Find flight deals from Mississippi to Des Moines

Keep the following information in mind while searching for Mississippi to Des Moines flight deals. Data was last updated December 3, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(American Airlines)

One-way from

$96
(Delta)
Provider with most accurate pricing for Jackson-Evers Intl-Des Moines flight deals.
Search Deals
Provider most trusted by Cheapflights users for Jackson-Evers Intl-Des Moines flights.
Search Deals
From Mississippi to Des Moines
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One-way flight from Mississippi to Des Moines
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 3, 2025.
Use the filters below to find and compare flights from Mississippi to Des Moines that are best for you.

Fly from

Mississippi

Fly to

Des Moines

Route

Depart

Return

Price

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Thu 1/15

5:50 am-10:19 am

1 stop4h 29m

Des Moines

Wed 1/21

5:16 pm-11:13 pm

1 stop5h 57m

$184

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Thu 1/15

7:30 am-4:00 pm

1 stop8h 30m

Des Moines

Wed 1/21

6:10 am-5:10 pm

2 stops11h 00m

$225

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Thu 1/15

8:37 am-4:24 pm

2 stops7h 47m

Des Moines

Wed 1/21

11:35 am-8:32 pm

2 stops8h 57m

$246

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Fri 1/30

4:02 pm-10:29 pm

1 stop6h 27m

Des Moines

Tue 2/3

5:16 pm-10:01 pm

1 stop4h 45m

$249

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Wed 12/31

3:49 pm-10:07 pm

1 stop6h 18m

Des Moines

Wed 1/7

11:35 am-6:27 pm

1 stop6h 52m

$253

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Tue 12/30

5:28 pm-11:46 pm

1 stop6h 18m

Des Moines

Tue 1/6

5:51 pm-10:51 pm

1 stop5h 00m

$253

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

Thu 1/8

6:05 am-12:14 pm

1 stop6h 09m

Des Moines

Sat 1/10

6:24 am-3:09 pm

2 stops8h 45m

$254

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Fri 1/23

6:00 am-10:41 am

1 stop4h 41m

Des Moines

Sun 1/25

4:21 pm-10:40 pm

1 stop6h 19m

$279

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Wed 12/24

11:25 am-7:21 pm

1 stop7h 56m

Des Moines

Fri 1/2

3:14 pm-9:58 pm

1 stop6h 44m

$289

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Fri 1/23

8:37 am-4:24 pm

2 stops7h 47m

Des Moines

Sun 1/25

6:00 am-3:18 pm

2 stops9h 18m

$289

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/3

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Best time to book a flight from Mississippi to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Des Moines
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mississippi?

    Des Moines (DSM) is the airport you will fly into if you book a flight from Mississippi to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • How long is the flight from Mississippi to Des Moines?

    Departing from Mississippi to Des Moines will take you 4h 29m. There are 491 mi between Mississippi and Des Moines. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Mississippi to Des Moines?

    The most popular flight routes from Mississippi to Des Moines are Memphis - Des Moines, Baton Rouge Ryan - Des Moines and Gulfport Biloxi Regional - Des Moines.

  • Can I find deals for flights from Mississippi to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mississippi to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Des Moines.

  • Can I find deals for business class flights from Mississippi to Des Moines?

    Yes. Cheapflights offers flight deals from Mississippi to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Alternative routes for Mississippi to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Mississippi to Des Moines

Discover the top airline that operate flights from Mississippi to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$124Average$254FlexibilityNo cancel feeOn-timeN/A

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