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Des Moines

$132+ Cheap flights from Mississippi to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/30. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — DSM
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Mississippi to Des Moines

Keep the following information in mind while searching for Mississippi to Des Moines flight deals. Data was last updated September 17, 2025.

Round-trip from

$249
(American Airlines)

One-way from

$132
(Kiwi.com)
From Mississippi to Des Moines
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One-way flight from Mississippi to Des Moines
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Find flight deals from Mississippi to Des Moines

Cheapest flights from Mississippi to Des Moines
Explore the most affordable flight options available from Mississippi to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/84:28 pmBTR - DSM
1 stop6h 48mAmerican Airlines
Tue 10/143:48 pmDSM - BTR
1 stop7h 15mAmerican Airlines
Deal found 9/15$249
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/166:00 amBTR - DSM
1 stop4h 43mDelta
Wed 1/76:20 amDSM - BTR
2 stops9h 36mDelta
Deal found 9/17$254
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:00 amMEM - DSM
1 stop4h 26mDelta
Mon 11/32:40 pmDSM - MEM
1 stop7h 16mDelta
Deal found 9/15$256
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:00 amMOB - DSM
1 stop7h 20mDelta
Sat 10/45:12 pmDSM - MOB
1 stop6h 00mDelta
Deal found 9/14$259
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/306:40 amMOB - DSM
2 stops8h 44mAmerican Airlines
Sat 10/47:08 amDSM - MOB
2 stops9h 44mAmerican Airlines
Deal found 9/14$269
This American Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/173:32 pmMOB - DSM
1 stop7h 24mAmerican Airlines
Sat 10/183:48 pmDSM - MOB
1 stop7h 30mAmerican Airlines
Deal found 9/14$279
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/167:39 amBTR - DSM
1 stop5h 51mDelta
Tue 1/611:04 amDSM - BTR
1 stop4h 52mDelta
Deal found 9/17$279
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/167:39 amBTR - DSM
1 stop5h 51mDelta
Sun 1/410:28 amDSM - BTR
2 stops11h 24mDelta
Deal found 9/15$284
This Delta deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:00 amMEM - DSM
1 stop4h 26mDelta
Sun 11/22:40 pmDSM - MEM
1 stop7h 16mDelta
Deal found 9/17$287
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/166:00 amBTR - DSM
2 stops10h 16mDelta
Thu 1/16:15 amDSM - BTR
2 stops8h 45mDelta
Deal found 9/15$289
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/166:00 amBTR - DSM
1 stop7h 30mDelta
Fri 1/26:15 amDSM - BTR
2 stops8h 45mDelta
Deal found 9/15$299
This Delta deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1410:29 amMEM - DSM
1 stop7h 17mDelta
Sun 11/166:33 pmDSM - MEM
1 stop4h 47mDelta
Deal found 9/15$309

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Mississippi to Des Moines that are best for you.

Fly from

Mississippi

Fly to

Des Moines

Route

Depart

Return

Price

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Wed 12/17

6:00 am-10:43 am

1 stop4h 43m

Des Moines

Tue 1/6

11:04 am-3:56 pm

1 stop4h 52m

$249

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Tue 12/16

6:00 am-1:30 pm

1 stop7h 30m

Des Moines

Tue 1/6

11:04 am-3:56 pm

1 stop4h 52m

$249

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Tue 12/16

7:39 am-1:30 pm

1 stop5h 51m

Des Moines

Wed 1/7

6:20 am-3:56 pm

2 stops9h 36m

$254

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Thu 12/18

6:00 am-10:43 am

1 stop4h 43m

Des Moines

Thu 1/1

6:15 am-3:00 pm

2 stops8h 45m

$254

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Tue 12/16

7:39 am-1:30 pm

1 stop5h 51m

Des Moines

Mon 1/5

10:55 am-8:09 pm

2 stops9h 14m

$254

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Thu 12/18

6:00 am-10:43 am

1 stop4h 43m

Des Moines

Tue 1/6

6:20 am-3:56 pm

2 stops9h 36m

$254

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Wed 12/17

6:00 am-10:43 am

1 stop4h 43m

Des Moines

Thu 1/1

6:15 am-3:00 pm

2 stops8h 45m

$254

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Fri 10/31

6:00 am-10:26 am

1 stop4h 26m

Des Moines

Mon 11/3

2:40 pm-9:56 pm

1 stop7h 16m

$256

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Tue 9/30

6:00 am-1:20 pm

1 stop7h 20m

Des Moines

Sat 10/4

5:12 pm-11:12 pm

1 stop6h 00m

$259

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Tue 9/30

6:40 am-3:24 pm

2 stops8h 44m

Des Moines

Sat 10/4

7:08 am-4:52 pm

2 stops9h 44m

$269

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/16

Showing 1-10 of 35 results
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Best time to book a flight from Mississippi to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Des Moines
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mississippi?

    Des Moines (DSM) is the airport you will fly into if you book a flight from Mississippi to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • How long is the flight from Mississippi to Des Moines?

    Departing from Mississippi to Des Moines will take you 4h 43m. There are 773 mi between Mississippi and Des Moines. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Mississippi to Des Moines one-way?

    The cheapest airline one-way is United Airlines, with whom users have recently found tickets for as low as $164. However, be on the lookout for offers from American Airlines and Delta, as they are both options that can get you from Mississippi to Des Moines for a low price.

  • What are the most popular routes from Mississippi to Des Moines?

    The most popular flight routes from Mississippi to Des Moines are Baton Rouge Ryan - Des Moines, Memphis - Des Moines and Mobile - Des Moines.

  • Can I find deals for flights from Mississippi to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mississippi to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Des Moines.

  • Can I find deals for business class flights from Mississippi to Des Moines?

    Yes. Cheapflights offers flight deals from Mississippi to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Mississippi to Des Moines (average of $336). Flying from Mississippi to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Alternative routes for Mississippi to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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O'Hare Intl to Des Moines flights
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Newark to Cedar Rapids flights
Philadelphia to Cedar Rapids flights
Portland to Omaha flights
Midway to Omaha flights
San Francisco to Des Moines flights
Dulles Intl to Cedar Rapids flights
LaGuardia to Cedar Rapids flights
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Miami to Omaha flights

Top 2 airlines flying from Mississippi to Des Moines

Discover the top 2 airlines that operate flights from Mississippi to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$124Average$254FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$358FlexibilityNo cancel feeOn-time71%

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