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Des Moines

$150+ Cheap flights from Mississippi to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/23. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — DSM
nov. 28 — dic. 51
vie. 11/28
vie. 12/5
1 adult, Economy
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Cheap flight deals from Mississippi to Des Moines

Keep the following information in mind while searching for Mississippi to Des Moines flight deals. Data was last updated octubre 29, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(American Airlines)

One-way from

$150
(Kiwi.com)
Provider with most accurate pricing for Jackson-Evers Intl-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Jackson-Evers Intl-Des Moines flights.
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From Mississippi to Des Moines
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One-way flight from Mississippi to Des Moines
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Find flight deals from Mississippi to Des Moines

Cheapest flights from Mississippi to Des Moines
Explore the most affordable flight options available from Mississippi to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on octubre 29, 2025.

This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/47:15 amGPT - DSM
1 stop8h 22mAmerican Airlines
lun. 12/85:00 amDSM - GPT
1 stop7h 25mAmerican Airlines
Deal found 10/28$249
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/46:00 amGPT - DSM
1 stop4h 38mDelta
lun. 12/82:59 pmDSM - GPT
2 stops7h 04mDelta
Deal found 10/28$254
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/125:30 pmMOB - DSM
1 stop6h 00mAmerican Airlines
dom. 11/163:49 pmDSM - MOB
1 stop7h 01mAmerican Airlines
Deal found 10/28$259
This American Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 12/126:35 amMEM - DSM
1 stop7h 58mAmerican Airlines
vie. 12/195:39 pmDSM - MEM
1 stop5h 49mAmerican Airlines
Deal found 10/28$313
This Delta deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/266:00 amMEM - DSM
1 stop7h 32mDelta
vie. 12/265:55 pmDSM - MEM
1 stop4h 26mDelta
Deal found 10/27$317
This United Airlines deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/84:55 pmMOB - DSM
1 stop5h 34mUnited Airlines
lun. 12/158:15 amDSM - MOB
1 stop5h 45mUnited Airlines
Deal found 10/29$319
This United Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 11/89:00 amMEI - DSM
1 stop5h 11mUnited Airlines
mar. 11/112:52 pmDSM - MEI
1 stop5h 30mUnited Airlines
Deal found 10/27$344
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/185:13 amMOB - DSM
1 stop5h 36mAmerican Airlines
mar. 12/235:07 amDSM - MOB
1 stop4h 50mAmerican Airlines
Deal found 10/27$357
This United Airlines deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/129:05 amMOB - DSM
2 stops11h 40mUnited Airlines
dom. 11/165:45 amDSM - MOB
2 stops8h 37mUnited Airlines
Deal found 10/28$373
This Delta deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/172:10 pmMEM - DSM
1 stop6h 37mDelta
jue. 11/2010:21 amDSM - MEM
1 stop6h 42mDelta
Deal found 10/28$377
This Southwest deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/177:55 amMEM - DSM
1 stop7h 40mSouthwest
jue. 11/206:15 amDSM - MEM
2 stops9h 50mSouthwest
Deal found 10/28$382
This American Airlines deal was found by Cheapflights users on 10/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 11/1110:29 amMEM - DSM
1 stop5h 52mAmerican Airlines
sáb. 11/152:16 pmDSM - MEM
1 stop5h 30mAmerican Airlines
Deal found 10/27$387

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 29, 2025.
Use the filters below to find and compare flights from Mississippi to Des Moines that are best for you.

Fly from

Mississippi

Fly to

Des Moines

Route

Depart

Return

Price

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

lun. 1/12

4:00 pm-10:31 pm

1 stop6h 31m

Des Moines

lun. 1/19

5:16 pm-10:05 pm

1 stop4h 49m

$249

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

jue. 12/4

7:15 am-3:37 pm

1 stop8h 22m

Des Moines

lun. 12/8

5:00 am-12:25 pm

1 stop7h 25m

$249

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

lun. 1/12

1:57 pm-11:44 pm

2 stops9h 47m

Des Moines

lun. 1/19

8:10 am-1:22 pm

1 stop5h 12m

$254

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

jue. 12/4

6:00 am-10:38 am

1 stop4h 38m

Des Moines

lun. 12/8

2:59 pm-10:03 pm

2 stops7h 04m

$254

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

mié. 11/12

5:30 pm-11:30 pm

1 stop6h 00m

Des Moines

dom. 11/16

3:49 pm-10:50 pm

1 stop7h 01m

$259

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

mié. 4/15

5:55 am-10:16 am

1 stop4h 21m

Des Moines

sáb. 4/18

5:45 am-11:29 am

1 stop5h 44m

$274

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

vie. 12/12

6:35 am-2:33 pm

1 stop7h 58m

Des Moines

vie. 12/19

5:39 pm-11:28 pm

1 stop5h 49m

$313

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

mié. 11/26

6:00 am-1:32 pm

1 stop7h 32m

Des Moines

vie. 12/26

5:55 pm-10:21 pm

1 stop4h 26m

$317

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

lun. 12/8

4:55 pm-10:29 pm

1 stop5h 34m

Des Moines

lun. 12/15

8:15 am-2:00 pm

1 stop5h 45m

$319

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

sáb. 2/21

5:00 am-10:46 am

1 stop5h 46m

Des Moines

mar. 2/24

3:25 pm-10:59 pm

1 stop7h 34m

$319

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/27

Showing 1-10 of 30 results
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Best time to book a flight from Mississippi to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Des Moines
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mississippi?

    Des Moines (DSM) is the airport you will fly into if you book a flight from Mississippi to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • How long is the flight from Mississippi to Des Moines?

    Departing from Mississippi to Des Moines will take you 6h 31m. There are 810 mi between Mississippi and Des Moines. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Mississippi to Des Moines one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $150. However, be on the lookout for offers from American Airlines and United Airlines, as they are both options that can get you from Mississippi to Des Moines for a low price.

  • What are the most popular routes from Mississippi to Des Moines?

    The most popular flight routes from Mississippi to Des Moines are Memphis - Des Moines, Baton Rouge Ryan - Des Moines and Gulfport Biloxi Regional - Des Moines.

  • Can I find deals for flights from Mississippi to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mississippi to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Des Moines.

  • Can I find deals for business class flights from Mississippi to Des Moines?

    Yes. Cheapflights offers flight deals from Mississippi to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Alternative routes for Mississippi to Des Moines

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Top 2 airlines flying from Mississippi to Des Moines

Discover the top 2 airlines that operate flights from Mississippi to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated octubre 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$124Average$254FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$248Average$358FlexibilityNo cancel feeOn-time71%

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