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Des Moines

$99+ Cheap flights from Mississippi to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/6. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — DSM
Aug 3 — Aug 101
Sun 8/3
Sun 8/10
1 adult, Economy
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Cheap flight deals from Mississippi to Des Moines

Keep the following information in mind while searching for Mississippi to Des Moines flight deals. Data was last updated July 29, 2025.

Round-trip from

$241
(American Airlines)

One-way from

$99
(American Airlines)
From Mississippi to Des Moines
Search Deals
One-way flight from Mississippi to Des Moines
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Find flight deals from Mississippi to Des Moines

Cheapest flights from Mississippi to Des Moines
Explore the most affordable flight options available from Mississippi to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 29, 2025.

This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/125:51 pmMEM - DSM
1 stop5h 54mAmerican Airlines
Mon 9/156:09 pmDSM - MEM
1 stop5h 50mAmerican Airlines
Deal found 7/29$241
This Delta deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/196:00 amMOB - DSM
1 stop7h 27mDelta
Tue 8/266:30 pmDSM - MOB
1 stop4h 46mDelta
Deal found 7/29$249
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/146:30 pmGPT - DSM
1 stop5h 15mAmerican Airlines
Mon 8/185:29 pmDSM - GPT
1 stop4h 55mAmerican Airlines
Deal found 7/27$254
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1910:08 amMOB - DSM
2 stops9h 12mAmerican Airlines
Tue 8/266:00 amDSM - MOB
2 stops10h 36mAmerican Airlines
Deal found 7/29$259
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/245:50 pmMEM - DSM
1 stop4h 49mDelta
Sun 8/315:44 amDSM - MEM
1 stop4h 41mDelta
Deal found 7/28$277
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/89:00 amMEI - DSM
2 stops11h 45mUnited Airlines
Tue 11/112:52 pmDSM - MEI
1 stop5h 30mUnited Airlines
Deal found 7/28$314
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/106:00 amGTR - DSM
1 stop4h 39mDelta
Tue 8/196:00 amDSM - GTR
2 stops7h 38mDelta
Deal found 7/27$342
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/129:54 amMEM - DSM
1 stop4h 47mUnited Airlines
Sat 8/166:00 amDSM - MEM
1 stop8h 07mUnited Airlines
Deal found 7/28$367
This Delta deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/126:00 pmGPT - DSM
1 stop4h 39mDelta
Thu 8/142:12 pmDSM - GPT
1 stop7h 26mDelta
Deal found 7/28$407
This Delta deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/154:39 pmBTR - DSM
1 stop5h 58mDelta
Tue 9/1611:25 amDSM - BTR
1 stop4h 27mDelta
Deal found 7/27$417
This American Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/103:29 pmGTR - DSM
1 stop7h 28mAmerican Airlines
Tue 8/199:28 amDSM - GTR
1 stop5h 31mAmerican Airlines
Deal found 7/27$426
This Southwest deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/303:45 pmMEM - DSM
2 stops7h 30mSouthwest
Fri 8/11:35 pmDSM - MEM
2 stops11h 00mSouthwest
Deal found 7/26$497

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
Use the filters below to find and compare flights from Mississippi to Des Moines that are best for you.

Fly from

Mississippi

Fly to

Des Moines

Route

Depart

Return

Price

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Fri 9/12

5:51 pm-11:45 pm

1 stop5h 54m

Des Moines

Mon 9/15

6:09 pm-11:59 pm

1 stop5h 50m

$241

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Tue 8/19

6:00 am-1:27 pm

1 stop7h 27m

Des Moines

Tue 8/26

6:30 pm-11:16 pm

1 stop4h 46m

$249

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

Thu 8/14

6:30 pm-11:45 pm

1 stop5h 15m

Des Moines

Mon 8/18

5:29 pm-10:24 pm

1 stop4h 55m

$254

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Tue 8/19

10:08 am-7:20 pm

2 stops9h 12m

Des Moines

Tue 8/26

6:00 am-4:36 pm

2 stops10h 36m

$259

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Sun 8/24

5:50 pm-10:39 pm

1 stop4h 49m

Des Moines

Sun 8/31

5:44 am-10:25 am

1 stop4h 41m

$277

MeridianDes Moines

MEI - DSM

MEIDSM

Meridian Key Field

Sat 11/8

9:00 am-8:45 pm

2 stops11h 45m

Des Moines

Tue 11/11

2:52 pm-8:22 pm

1 stop5h 30m

$314

ColumbusDes Moines

GTR - DSM

GTRDSM

Columbus Golden Triangle Reg.

Sun 8/10

6:00 am-10:39 am

1 stop4h 39m

Des Moines

Tue 8/19

6:00 am-1:38 pm

2 stops7h 38m

$342

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Tue 8/12

9:54 am-2:41 pm

1 stop4h 47m

Des Moines

Sat 8/16

6:00 am-2:07 pm

1 stop8h 07m

$367

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

Tue 8/12

6:00 pm-10:39 pm

1 stop4h 39m

Des Moines

Thu 8/14

2:12 pm-9:38 pm

1 stop7h 26m

$407

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Mon 9/15

4:39 pm-10:37 pm

1 stop5h 58m

Des Moines

Tue 9/16

11:25 am-3:52 pm

1 stop4h 27m

$417

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/27

Showing 1-10 of 24 results
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2
3

Best time to book a flight from Mississippi to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Des Moines
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated July 29, 2025.
Read reviews from past customers who have flown Southwest, Delta, and United Airlines from Mississippi to Des Moines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Southwest
8.0
Very good
4,238 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Delta
8.0
Very good
7,977 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
United Airlines
7.4
Good
8,899 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.
Frontier
5.9
Fair
3,238 reviews
Southwest
8.0
Very good
4,238 reviews

Food

7.0

Crew

8.6

Boarding

8.1

Overall

8.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Gina,Jul 2025

LAS - DEN

We experienced bad weather, which turned our 1.5 hour flight from Las Vegas to Denver, into 3.5. The pilot and crew kept us updated and explained that we had to circle and or possibly redirect to another airport. After circling for sometime, we were able to land smoothly in Denver. Thank you to all the flight crew, tower control, and all who got us to our destination safely.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mississippi?

    Des Moines (DSM) is the airport you will fly into if you book a flight from Mississippi to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • What are the cheapest airlines to fly from Mississippi to Des Moines one-way?

    The cheapest airline one-way is American Airlines, with whom users have recently found tickets for as low as $99. However, be on the lookout for offers from Delta and Southwest, as they are both options that can get you from Mississippi to Des Moines for a low price.

  • What are the most popular routes from Mississippi to Des Moines?

    The most popular flight routes from Mississippi to Des Moines are Gulfport Biloxi Regional - Des Moines, Memphis - Des Moines and Baton Rouge Ryan - Des Moines.

  • Can I find deals for flights from Mississippi to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mississippi to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Des Moines.

  • Can I find deals for business class flights from Mississippi to Des Moines?

    Yes. Cheapflights offers flight deals from Mississippi to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Mississippi to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Mississippi to Des Moines (average of $336). Flying from Mississippi to Des Moines in June is currently the most expensive (average of $402). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Altoona
Ames
Johnston
Boone
West Des Moines
Ankeny

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Alternative routes for Mississippi to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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LaGuardia to Cedar Rapids flights
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Top 2 airlines flying from Mississippi to Des Moines

Discover the top 2 airlines that operate flights from Mississippi to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 29, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$124Average$254FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$268Average$358FlexibilityNo cancel feeOn-time71%

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