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Des Moines

$227+ Cheap flights from Mississippi to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/27. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — DSM
Dec 19 — Dec 261
Fri 12/19
Fri 12/26
1 adult, Economy
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Cheap flight deals from Mississippi to Des Moines

Keep the following information in mind while searching for Mississippi to Des Moines flight deals. Data was last updated November 19, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(American Airlines)

One-way from

$227
(United Airlines)
Provider with most accurate pricing for Jackson-Evers Intl-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Jackson-Evers Intl-Des Moines flights.
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From Mississippi to Des Moines
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One-way flight from Mississippi to Des Moines
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Find flight deals from Mississippi to Des Moines

Cheapest flights from Mississippi to Des Moines
Explore the most affordable flight options available from Mississippi to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 19, 2025.

This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/304:21 pmBTR - DSM
1 stop7h 14mAmerican Airlines
Fri 1/22:07 pmDSM - BTR
1 stop5h 50mAmerican Airlines
Deal found 11/18$249
This Delta deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:55 amMEM - DSM
1 stop4h 26mDelta
Sat 12/612:31 pmDSM - MEM
1 stop4h 29mDelta
Deal found 11/17$251
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/165:31 amBTR - DSM
2 stops10h 54mAmerican Airlines
Fri 1/22:07 pmDSM - BTR
1 stop5h 50mAmerican Airlines
Deal found 11/19$254
This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/23:32 pmMEM - DSM
2 stops8h 23mAmerican Airlines
Sat 12/63:38 pmDSM - MEM
1 stop6h 57mAmerican Airlines
Deal found 11/17$256
This American Airlines deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/186:00 amBTR - DSM
2 stops9h 24mAmerican Airlines
Thu 1/16:40 amDSM - BTR
2 stops9h 24mAmerican Airlines
Deal found 11/19$259
This Delta deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/47:39 amBTR - DSM
1 stop5h 52mDelta
Mon 12/82:16 pmDSM - BTR
1 stop7h 37mDelta
Deal found 11/17$264
This United Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/35:11 pmGPT - DSM
1 stop5h 18mUnited Airlines
Sun 12/78:15 amDSM - GPT
1 stop7h 47mUnited Airlines
Deal found 11/18$279
This American Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/25:08 amMOB - DSM
1 stop5h 32mAmerican Airlines
Sat 12/65:00 amDSM - MOB
1 stop4h 57mAmerican Airlines
Deal found 11/17$279
This Delta deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/37:39 amBTR - DSM
1 stop5h 52mDelta
Sun 12/72:16 pmDSM - BTR
1 stop7h 37mDelta
Deal found 11/18$279
This Kiwi.com deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/48:26 pmMEM - DSM
1 stop26h 46mMultiple Airlines
Sun 12/78:30 amDSM - MEM
1 stop11h 27mMultiple Airlines
Deal found 11/18$283
This American Airlines deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:40 amGPT - DSM
2 stops9h 45mAmerican Airlines
Sun 12/73:38 pmDSM - GPT
1 stop7h 20mAmerican Airlines
Deal found 11/18$284
This United Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/24:55 pmMOB - DSM
1 stop5h 34mUnited Airlines
Sat 12/611:35 amDSM - MOB
2 stops10h 12mUnited Airlines
Deal found 11/17$284

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 19, 2025.
Use the filters below to find and compare flights from Mississippi to Des Moines that are best for you.

Fly from

Mississippi

Fly to

Des Moines

Route

Depart

Return

Price

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Thu 12/18

10:09 am-5:09 pm

1 stop7h 00m

Des Moines

Thu 1/1

3:28 pm-10:37 pm

1 stop7h 09m

$249

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Wed 12/31

7:11 am-1:21 pm

1 stop6h 10m

Des Moines

Sat 1/3

11:32 am-5:23 pm

1 stop5h 51m

$249

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Tue 12/2

5:55 am-10:21 am

1 stop4h 26m

Des Moines

Sat 12/6

12:31 pm-5:00 pm

1 stop4h 29m

$251

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

Thu 1/8

6:05 am-12:14 pm

1 stop6h 09m

Des Moines

Sat 1/10

12:25 pm-9:53 pm

2 stops9h 28m

$254

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Tue 12/16

5:31 am-4:25 pm

2 stops10h 54m

Des Moines

Fri 1/2

2:07 pm-7:57 pm

1 stop5h 50m

$254

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Tue 12/2

3:32 pm-11:55 pm

2 stops8h 23m

Des Moines

Sat 12/6

3:38 pm-10:35 pm

1 stop6h 57m

$256

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Thu 12/4

7:39 am-1:31 pm

1 stop5h 52m

Des Moines

Mon 12/8

2:16 pm-9:53 pm

1 stop7h 37m

$264

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Wed 4/15

5:55 am-10:16 am

1 stop4h 21m

Des Moines

Sat 4/18

5:15 pm-10:55 pm

1 stop5h 40m

$274

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

Wed 12/3

5:11 pm-10:29 pm

1 stop5h 18m

Des Moines

Sun 12/7

8:15 am-4:02 pm

1 stop7h 47m

$279

MobileDes Moines

MOB - DSM

MOBDSM

Mobile

Tue 12/2

5:08 am-10:40 am

1 stop5h 32m

Des Moines

Sat 12/6

5:00 am-9:57 am

1 stop4h 57m

$279

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/19

Showing 1-10 of 38 results
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Best time to book a flight from Mississippi to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Des Moines
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mississippi?

    Des Moines (DSM) is the airport you will fly into if you book a flight from Mississippi to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • How long is the flight from Mississippi to Des Moines?

    Departing from Mississippi to Des Moines will take you 4h 26m. There are 491 mi between Mississippi and Des Moines. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Mississippi to Des Moines one-way?

    The cheapest airline one-way is United Airlines, with whom users have recently found tickets for as low as $227. However, be on the lookout for offers from American Airlines and Delta, as they are both options that can get you from Mississippi to Des Moines for a low price.

  • What are the most popular routes from Mississippi to Des Moines?

    The most popular flight routes from Mississippi to Des Moines are Baton Rouge Ryan - Des Moines, Memphis - Des Moines and Gulfport Biloxi Regional - Des Moines.

  • Can I find deals for flights from Mississippi to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mississippi to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Des Moines.

  • Can I find deals for business class flights from Mississippi to Des Moines?

    Yes. Cheapflights offers flight deals from Mississippi to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Alternative routes for Mississippi to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Dulles Intl to Cedar Rapids flights
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Baltimore to Cedar Rapids flights
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Newark to Moline flights
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John F Kennedy Intl to Moline flights
Detroit to Omaha flights
Nashville to Cedar Rapids flights
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Los Angeles to Des Moines flights
Love Field to Omaha flights
Love Field to Des Moines flights
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Top airline flying from Mississippi to Des Moines

Discover the top airline that operate flights from Mississippi to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 19, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$124Average$254FlexibilityNo cancel feeOn-timeN/A

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