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Des Moines

$139+ Cheap flights from Mississippi to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/15. Fares are subject to change and may not be available on all flights or dates of travel.
JAN — DSM
Dec 12 — Dec 191
Fri 12/12
Fri 12/19
1 adult, Economy
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Cheap flight deals from Mississippi to Des Moines

Keep the following information in mind while searching for Mississippi to Des Moines flight deals. Data was last updated November 12, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$249
(United Airlines)

One-way from

$139
(Delta)
Provider with most accurate pricing for Jackson-Evers Intl-Des Moines flight deals.
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Provider most trusted by Cheapflights users for Jackson-Evers Intl-Des Moines flights.
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From Mississippi to Des Moines
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One-way flight from Mississippi to Des Moines
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Find flight deals from Mississippi to Des Moines

Cheapest flights from Mississippi to Des Moines
Explore the most affordable flight options available from Mississippi to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 12, 2025.

This United Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/105:11 pmGPT - DSM
1 stop5h 18mUnited Airlines
Wed 12/172:53 pmDSM - GPT
1 stop6h 29mUnited Airlines
Deal found 11/10$249
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/106:07 amBTR - DSM
1 stop7h 24mDelta
Sun 12/142:16 pmDSM - BTR
1 stop7h 37mDelta
Deal found 11/11$249
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/255:00 amMEM - DSM
1 stop8h 21mAmerican Airlines
Thu 1/15:39 pmDSM - MEM
1 stop5h 49mAmerican Airlines
Deal found 11/10$251
This Delta deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/106:00 amGPT - DSM
1 stop4h 38mDelta
Wed 12/176:17 amDSM - GPT
2 stops10h 59mDelta
Deal found 11/10$254
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/106:40 amGPT - DSM
2 stops9h 45mAmerican Airlines
Wed 12/171:17 pmDSM - GPT
2 stops9h 16mAmerican Airlines
Deal found 11/10$259
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/117:39 amBTR - DSM
1 stop5h 52mDelta
Sun 12/1410:20 amDSM - BTR
2 stops9h 37mDelta
Deal found 11/11$279
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/97:39 amBTR - DSM
2 stops8h 37mDelta
Sun 12/1410:20 amDSM - BTR
2 stops9h 37mDelta
Deal found 11/11$284
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/237:11 pmMEM - DSM
1 stop26h 30mMultiple Airlines
Thu 11/279:00 amDSM - MEM
2 stops28h 12mMultiple Airlines
Deal found 11/11$316
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/126:00 amMEM - DSM
1 stop4h 38mDelta
Sun 12/1410:20 amDSM - MEM
1 stop6h 40mDelta
Deal found 11/11$327
This American Airlines deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/167:20 amBTR - DSM
1 stop7h 13mAmerican Airlines
Fri 1/211:32 amDSM - BTR
1 stop5h 51mAmerican Airlines
Deal found 11/10$328
This Kiwi.com deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/262:15 pmMEM - DSM
1 stop23h 51mMultiple Airlines
Sun 11/308:19 pmDSM - MEM
1 stop22h 45mMultiple Airlines
Deal found 11/11$345
This American Airlines deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:43 amGPT - DSM
1 stop7h 48mAmerican Airlines
Thu 11/205:00 amDSM - GPT
1 stop6h 39mAmerican Airlines
Deal found 11/11$354

Cheapflights Fare Finder

 
Customize your flight search to find flights from Mississippi to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 12, 2025.
Use the filters below to find and compare flights from Mississippi to Des Moines that are best for you.

Fly from

Mississippi

Fly to

Des Moines

Route

Depart

Return

Price

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

Wed 12/10

5:11 pm-10:29 pm

1 stop5h 18m

Des Moines

Wed 12/17

2:53 pm-9:22 pm

1 stop6h 29m

$249

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Tue 12/9

10:32 am-5:47 pm

1 stop7h 15m

Des Moines

Sun 12/14

2:16 pm-9:53 pm

1 stop7h 37m

$249

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Wed 12/10

6:07 am-1:31 pm

1 stop7h 24m

Des Moines

Sun 12/14

2:16 pm-9:53 pm

1 stop7h 37m

$249

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Wed 12/10

6:03 pm-10:29 pm

1 stop4h 26m

Des Moines

Sun 12/14

8:15 am-1:14 pm

1 stop4h 59m

$249

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Thu 12/25

5:00 am-1:21 pm

1 stop8h 21m

Des Moines

Thu 1/1

5:39 pm-11:28 pm

1 stop5h 49m

$251

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Wed 1/7

5:00 pm-10:30 pm

1 stop5h 30m

Des Moines

Wed 1/14

1:35 pm-8:41 pm

1 stop7h 06m

$251

Baton RougeDes Moines

BTR - DSM

BTRDSM

Baton Rouge Ryan

Wed 12/10

7:20 am-4:25 pm

2 stops9h 05m

Des Moines

Sun 12/14

5:25 pm-10:32 pm

1 stop5h 07m

$254

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

Wed 12/10

6:00 am-10:38 am

1 stop4h 38m

Des Moines

Wed 12/17

6:17 am-5:16 pm

2 stops10h 59m

$254

MemphisDes Moines

MEM - DSM

MEMDSM

Memphis

Wed 1/7

2:45 pm-9:10 pm

2 stops6h 25m

Des Moines

Wed 1/14

12:05 pm-7:55 pm

1 stop7h 50m

$256

GulfportDes Moines

GPT - DSM

GPTDSM

Gulfport Biloxi Regional

Wed 12/10

6:40 am-4:25 pm

2 stops9h 45m

Des Moines

Wed 12/17

1:17 pm-10:33 pm

2 stops9h 16m

$259

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/12

Showing 1-10 of 30 results
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Best time to book a flight from Mississippi to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Mississippi with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Mississippi to Des Moines
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Mississippi to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Mississippi?

    Des Moines (DSM) is the airport you will fly into if you book a flight from Mississippi to Des Moines. It is only a 3.6 mi journey from Des Moines (DSM) to Des Moines’s city center.

  • How long is the flight from Mississippi to Des Moines?

    Departing from Mississippi to Des Moines will take you 5h 18m. There are 810 mi between Mississippi and Des Moines. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Mississippi to Des Moines?

    The most popular flight routes from Mississippi to Des Moines are Baton Rouge Ryan - Des Moines, Memphis - Des Moines and Mobile - Des Moines.

  • Can I find deals for flights from Mississippi to Des Moines that include hotel bookings?

    Yes. In addition to deals on Mississippi to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Mississippi to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Mississippi to Des Moines.

  • Can I find deals for business class flights from Mississippi to Des Moines?

    Yes. Cheapflights offers flight deals from Mississippi to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Des Moines?

Book flights to Des Moines if you plan to visit one of these locations
Johnston
Altoona
Boone
Ames
West Des Moines
Ankeny

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Alternative routes for Mississippi to Des Moines

See prices for flight routes from nearby airports that may be better suited for you.
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Baltimore to Omaha flights
Baltimore to Cedar Rapids flights
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Detroit to Des Moines flights
LaGuardia to Cedar Rapids flights
George Bush Intcntl to Omaha flights
Boston to Omaha flights
Dulles Intl to Des Moines flights
Denver to Moline flights
Seattle to Cedar Rapids flights
Portland to Omaha flights
Salt Lake City to Omaha flights
Salt Lake City to Moline flights
Dallas/Fort Worth to Moline flights
Sky Harbor Intl to Cedar Rapids flights
Portland to Cedar Rapids flights
San Diego to Omaha flights
Raleigh to Omaha flights
Midway to Omaha flights

Top airline flying from Mississippi to Des Moines

Discover the top airline that operate flights from Mississippi to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 12, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$124Average$254FlexibilityNo cancel feeOn-timeN/A

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