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Des Moines

$164+ Cheap flights from Key Largo, FL to Des Moines (DSM)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/11. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — DSM
Jul 7 — Jul 141
Mon 7/7
Mon 7/14
1 adult, Economy
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Cheap flight deals from Key Largo to Des Moines

Keep the following information in mind while searching for Key Largo to Des Moines flight deals. Data was last updated July 2, 2025.

Round-trip from

$178
(Southwest)

One-way from

$164
(Frontier)

Popular in

April

Cheapest in

November

Average price

$344
From Key Largo to Des Moines
Search Deals
One-way flight from Key Largo to Des Moines
Search Deals
Highest demand for flights based on searches. 3% potential increase in price ($14 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
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Find flight deals from Key Largo to Des Moines

Cheapest flights from Key Largo to Des Moines
Explore the most affordable flight options available from Key Largo to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 2, 2025.

This Southwest deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/296:55 pmMIA - DSM
1 stop4h 55mSouthwest
Mon 9/17:00 amDSM - MIA
1 stop7h 15mSouthwest
Deal found 7/2$178
This Delta deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2411:21 amMIA - DSM
1 stop8h 52mDelta
Mon 7/286:40 pmDSM - MIA
1 stop5h 15mDelta
Deal found 7/2$217
This Mytrip deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/1711:10 amMIA - DSM
1 stop12h 28mMultiple Airlines
Mon 7/212:00 pmDSM - MIA
2 stops21h 23mMultiple Airlines
Deal found 7/2$262
This United Airlines deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/317:00 amMIA - DSM
1 stop6h 14mUnited Airlines
Sat 11/11:05 pmDSM - MIA
2 stops9h 54mUnited Airlines
Deal found 7/1$282
This Orbitz deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/16:00 amMIA - DSM
1 stop13h 48mFrontier
Fri 8/87:33 pmDSM - MIA
1 stop9h 57mFrontier
Deal found 7/2$315
This American Airlines deal was found by Cheapflights users on 7/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/216:20 amMIA - DSM
1 stop8h 31mAmerican Airlines
Sun 9/214:04 pmDSM - MIA
1 stop7h 44mAmerican Airlines
Deal found 7/2$406

Cheapflights Fare Finder

Customize your flight search to find flights from Key Largo to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
Use the filters below to find and compare flights from Key Largo to Des Moines that are best for you.

Fly from

Key Largo

Fly to

Des Moines

Route

Depart

Return

Price

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Fri 8/29

6:55 pm-10:50 pm

1 stop4h 55m

Des Moines

Mon 9/1

7:00 am-3:15 pm

1 stop7h 15m

$178

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Thu 7/24

11:21 am-7:13 pm

1 stop8h 52m

Des Moines

Mon 7/28

6:40 pm-12:55 am

1 stop5h 15m

$217

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Thu 7/17

11:10 am-10:38 pm

1 stop12h 28m

Des Moines

Mon 7/21

2:00 pm-12:23 pm

2 stops21h 23m

$262

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Fri 8/1

6:00 am-6:48 pm

1 stop13h 48m

Des Moines

Fri 8/8

7:33 pm-6:30 am

1 stop9h 57m

$315

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Sun 9/21

6:20 am-1:51 pm

1 stop8h 31m

Des Moines

Sun 9/21

4:04 pm-12:48 am

1 stop7h 44m

$406

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Thu 8/28

6:05 am-2:10 pm

2 stops9h 05m

Des Moines

Mon 9/1

6:15 am-3:46 pm

1 stop8h 31m

$450

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Mon 8/11

6:00 am-6:48 pm

1 stop13h 48m

$164

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Tue 8/12

4:16 pm-9:47 pm

1 stop6h 31m

$183

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Tue 8/12

8:26 am-11:17 pm

2 stops15h 51m

$234

MiamiDes Moines

MIA - DSM

MIADSM

Miami

Mon 7/7

11:30 am-10:55 pm

2 stops12h 25m

$346

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/1

Showing 1-10 of 11 results
1
2

Best time to book a flight from Key Largo to Des Moines

Have a flexible travel schedule? Discover the best time to fly to Des Moines from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Des Moines

What is the cheapest month to book a flight from Key Largo to Des Moines?

Currently, August is the cheapest month in which you can book a flight from Key Largo to Des Moines (average of $336). Flying from Key Largo to Des Moines in June is currently the most expensive (average of $405). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to DSM?

Find hourly flight availability from Key Largo to Des Moines. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 2, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Key Largo to Des Moines as you normally would.

Reviews of airlines servicing Des Moines

Get insights into the airlines that provide service to Des Moines. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Des Moines. Reviews last updated July 2, 2025.
See what other customers who have flown with Southwest, Delta, and United Airlines from Key Largo to Des Moines have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,272 reviews

Entertainment

7.6

Food

7.0

Boarding

8.2

Overall

8.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Southwest
8.0
Very good
4,272 reviews
Southwest
8.0
Very good
4,272 reviews

Entertainment

7.6

Food

7.0

Boarding

8.2

Overall

8.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Delta
8.0
Very good
7,983 reviews
Southwest
8.0
Very good
4,272 reviews

Entertainment

7.6

Food

7.0

Boarding

8.2

Overall

8.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
United Airlines
7.4
Good
8,861 reviews
Southwest
8.0
Very good
4,272 reviews

Entertainment

7.6

Food

7.0

Boarding

8.2

Overall

8.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,272 reviews

Entertainment

7.6

Food

7.0

Boarding

8.2

Overall

8.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.
Frontier
5.9
Fair
3,290 reviews
Southwest
8.0
Very good
4,272 reviews

Entertainment

7.6

Food

7.0

Boarding

8.2

Overall

8.0

Crew

8.6

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

John,May 2025

PVD - BNA

It’s southwest so no frills but clean, efficient and got me to my location.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Des Moines. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Des Moines from Key Largo?

    Des Moines (DSM), located 3.6 mi from the city center, is the airport you fly into when you book flights from Key Largo to Des Moines. 4 airlines have flights to Des Moines from Key Largo on a regular basis. Booking flights from Key Largo to Des Moines should not be difficult; the airport handles an average of 0 inbound flights from Key Largo per day.

  • What are the cheapest airlines to fly from Key Largo to Des Moines one-way?

    The cheapest airlines for a one-way flight from Key Largo to Des Moines are Frontier ($164), United Airlines ($183), and American Airlines ($234).

  • What are the most reliable airlines from Key Largo to Des Moines?

    Looking for the most reliable airlines to get you to your destination on time? Our data shows these are most likely to get you from Key Largo to Des Moines on time: American Airlines (50%), Qatar Airways (50%), Republic Airways (50%).

  • Can I find deals for flights from Key Largo to Des Moines that include hotel bookings?

    Yes. In addition to deals on Key Largo to Des Moines flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Des Moines?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Des Moines.

  • Can I find deals for business class flights from Key Largo to Des Moines?

    Yes. Cheapflights offers flight deals from Key Largo to Des Moines by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Des Moines?

    Currently, August is the cheapest month in which you can book a flight from Key Largo to Des Moines (average of $336). Flying from Key Largo to Des Moines in June is currently the most expensive (average of $405). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Key Largo?

Book flights to Key Largo if you plan to visit one of these locations
Altoona
Ames
Johnston
Boone
West Des Moines
Ankeny

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Top 4 airlines flying from Key Largo to Des Moines

Discover the top 4 airlines that operate flights from Key Largo to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$107Average$160FlexibilityNo cancel feeOn-time88%
DeltaCheapest$216Average$376FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$276Average$430FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$326Average$377FlexibilityNo cancel feeOn-time63%

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