$66+ Cheap flights from San Diego to St. Louis (SAN - STL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/25. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — STL
Mar 23 — Mar 301
1 adult, Economy
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Find cheap flights from San Diego to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from San Diego to Lambert-St Louis are usually found in September or February, booked 75 days in advance, depart on a Thursday or Wednesday and return on a Tuesday
Cheap flight deals from San Diego to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from San Diego to St. LouisExplore the most affordable flight options available from San Diego to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 21, 2026.
Explore the most affordable flight options available from San Diego to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 21, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/2412:36 pm
SAN
- STL
1 stop28h 36m
Frontier
Mon 4/278:12 pm
STL
- SAN
1 stop25h 52m
Frontier
Deal found 2/17![Frontier logo]()
$136
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/129:18 pm
SAN
- STL
1 stop10h 31m
Frontier
Mon 3/168:12 pm
STL
- SAN
1 stop29h 56m
Frontier
Deal found 2/17![Frontier logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/712:36 pm
SAN
- STL
1 stop28h 36m
Frontier
Mon 5/118:12 pm
STL
- SAN
1 stop25h 52m
Frontier
Deal found 2/18![Frontier logo]()
$154
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/313:31 pm
SAN
- STL
2 stops16h 17m
Frontier
Mon 4/68:16 pm
STL
- SAN
1 stop21h 20m
Frontier
Deal found 2/17![Frontier logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/147:15 am
SAN
- STL
2 stops21h 35m
Frontier
Thu 4/168:12 pm
STL
- SAN
1 stop29h 49m
Frontier
Deal found 2/18![Frontier logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/147:15 am
SAN
- STL
2 stops21h 35m
Frontier
Fri 4/178:06 pm
STL
- SAN
1 stop25h 58m
Frontier
Deal found 2/18![Frontier logo]()
$174
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/239:58 pm
SAN
- STL
1 stop11h 21m
Frontier
Fri 3/278:12 pm
STL
- SAN
1 stop26h 21m
Frontier
Deal found 2/19![Frontier logo]()
$177
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/129:18 pm
SAN
- STL
1 stop10h 31m
Frontier
Tue 3/178:06 pm
STL
- SAN
1 stop19h 07m
Frontier
Deal found 2/19![Frontier logo]()
$185
Best flights from San Diego to St. LouisDiscover carefully curated flight deals from San Diego to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 21, 2026.
Discover carefully curated flight deals from San Diego to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 21, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/243:20 pm
SAN
- STL
2 stops25h 52m
Frontier
Mon 4/278:12 pm
STL
- SAN
1 stop25h 52m
Frontier
Deal found 2/17![Frontier logo]()
$162
This American Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1512:17 pm
SAN
- STL
1 stop8h 42m
American Airlines
Sat 4/252:12 pm
STL
- SAN
1 stop8h 38m
American Airlines
Deal found 2/19![American Airlines logo]()
$237
This Expedia deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/612:44 pm
SAN
- STL
1 stop9h 15m
Multiple Airlines
Fri 4/108:16 pm
STL
- SAN
1 stop5h 46m
Multiple Airlines
Deal found 2/18![Multiple Airlines logo]()
$279
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2111:00 am
SAN
- STL
1 stop7h 54m
United Airlines
Fri 4/242:40 pm
STL
- SAN
1 stop8h 42m
United Airlines
Deal found 2/17![United Airlines logo]()
$280
This Delta deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1511:40 am
SAN
- STL
2 stops10h 45m
Delta
Mon 4/202:20 pm
STL
- SAN
2 stops10h 09m
Delta
Deal found 2/16![Delta logo]()
$305
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/1510:30 am
SAN
- STL
2 stops22h 00m
Frontier
Sun 4/199:55 pm
STL
- SAN
1 stop22h 01m
Frontier
Deal found 2/19![Frontier logo]()
$228
This Priceline deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/286:25 am
SAN
- STL
1 stop5h 31m
Frontier
Sat 3/78:12 pm
STL
- SAN
1 stop5h 56m
Frontier
Deal found 2/17![Frontier logo]()
$251
This United Airlines deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/610:30 pm
SAN
- STL
1 stop7h 55m
United Airlines
Fri 4/107:45 am
STL
- SAN
1 stop9h 48m
United Airlines
Deal found 2/17![United Airlines logo]()
$296
This Delta deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1411:40 am
SAN
- STL
2 stops10h 45m
Delta
Fri 4/172:20 pm
STL
- SAN
2 stops10h 09m
Delta
Deal found 2/18![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/511:00 am
SAN
- STL
1 stop7h 43m
United Airlines
Sat 5/167:45 am
STL
- SAN
1 stop9h 48m
United Airlines
Deal found 2/19![United Airlines logo]()
$296
This Delta deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/207:10 pm
SAN
- STL
2 stops11h 36m
Delta
Fri 5/227:59 pm
STL
- SAN
1 stop5h 44m
Delta
Deal found 2/18![Delta logo]()
$320
This United Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/2011:00 am
SAN
- STL
1 stop7h 43m
United Airlines
Fri 5/226:00 am
STL
- SAN
1 stop7h 21m
United Airlines
Deal found 2/18![United Airlines logo]()
$308
Last-minute flights from San Diego to St. LouisDiscover last-minute flight deals from San Diego to St. Louis. Data last updated February 21, 2026 and is based on user searches.
Discover last-minute flight deals from San Diego to St. Louis. Data last updated February 21, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/69:18 pm
SAN
- STL
1 stop10h 31m
Frontier
Mon 3/98:12 pm
STL
- SAN
1 stop29h 56m
Frontier
Deal found 2/20![Frontier logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/129:18 pm
SAN
- STL
1 stop10h 31m
Frontier
Mon 3/168:12 pm
STL
- SAN
1 stop29h 56m
Frontier
Deal found 2/17![Frontier logo]()
$151
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/129:18 pm
SAN
- STL
1 stop10h 31m
Frontier
Tue 3/178:06 pm
STL
- SAN
1 stop19h 07m
Frontier
Deal found 2/19![Frontier logo]()
$185
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/139:18 pm
SAN
- STL
1 stop10h 31m
Frontier
Thu 3/198:06 pm
STL
- SAN
1 stop22h 07m
Frontier
Deal found 2/16![Frontier logo]()
$218
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/239:58 pm
SAN
- STL
1 stop11h 21m
Frontier
Fri 3/278:12 pm
STL
- SAN
1 stop26h 21m
Frontier
Deal found 2/19![Frontier logo]()
$177
This Kiwi.com deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/309:58 pm
SAN
- STL
2 stops33h 50m
Frontier
Fri 4/38:16 pm
STL
- SAN
1 stop29h 46m
Frontier
Deal found 2/18![Frontier logo]()
$192
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/313:31 pm
SAN
- STL
2 stops16h 17m
Frontier
Mon 4/68:16 pm
STL
- SAN
1 stop21h 20m
Frontier
Deal found 2/17![Frontier logo]()
$157
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/316:25 am
SAN
- STL
1 stop25h 23m
Frontier
Thu 4/210:12 pm
STL
- SAN
1 stop20h 03m
Frontier
Deal found 2/19![Frontier logo]()
$210
One-way flights from San Diego to St. LouisSearch for one-way flight options from San Diego to St. Louis. Find affordable one-way fares based on user searches. Data last updated February 21, 2026.
Search for one-way flight options from San Diego to St. Louis. Find affordable one-way fares based on user searches. Data last updated February 21, 2026.
This Kiwi.com deal was found by Cheapflights users on 2/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/257:05 am
SAN
- STL
1 stop10h 07m
Frontier
Deal found 2/16![Frontier logo]()
$66
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/178:25 am
SAN
- STL
1 stop23h 24m
Frontier
Deal found 2/20![Frontier logo]()
$67
This Trip.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/156:25 am
SAN
- STL
1 stop25h 24m
Frontier
Deal found 2/19![Frontier logo]()
$68
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/136:25 am
SAN
- STL
1 stop25h 24m
Frontier
Deal found 2/17![Frontier logo]()
$74
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/166:25 am
SAN
- STL
1 stop10h 56m
Frontier
Deal found 2/20![Frontier logo]()
$80
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1712:25 pm
SAN
- STL
1 stop29h 07m
Frontier
Deal found 2/20![Frontier logo]()
$82
This Kiwi.com deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/156:25 am
SAN
- STL
1 stop10h 47m
Frontier
Deal found 2/19![Frontier logo]()
$84
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/187:05 am
SAN
- STL
1 stop10h 07m
Frontier
Deal found 2/17![Frontier logo]()
$87
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/313:31 pm
SAN
- STL
2 stops16h 17m
Frontier
Deal found 2/17![Frontier logo]()
$93
Find flight deals from San Diego to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 21, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $136 (Kiwi.com) |
One-way from | $66 (Kiwi.com) |
Popular in | December |
Cheapest in | September |
Average price | $357 |
Good round-trip deal | $394 or less |
Good one-way deal | $229 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from San Diego to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 21, 2026.
Use the filters below to find and compare flights from San Diego to St. Louis that are best for you.
Fly from
San Diego
Fly to
St. Louis
Route
Depart
Return
Price
San DiegoSt. Louis
SAN - STL
SANSTL
San Diego
Fri 4/24
3:20 pm-7:12 pm
2 stops25h 52m
Lambert-St Louis
Mon 4/27
8:12 pm-8:04 pm
1 stop25h 52m
$162
San DiegoSt. Louis
SAN - STL
SANSTL
San Diego
Wed 4/15
10:30 am-10:30 am
2 stops22h 00m
Lambert-St Louis
Sun 4/19
9:55 pm-5:56 pm
1 stop22h 01m
$228
San DiegoSt. Louis
SAN - STL
SANSTL
San Diego
Wed 4/15
12:17 pm-10:59 pm
1 stop8h 42m
Lambert-St Louis
Sat 4/25
2:12 pm-8:50 pm
1 stop8h 38m
$237
San DiegoSt. Louis
SAN - STL
SANSTL
San Diego
Sat 2/28
6:25 am-1:56 pm
1 stop5h 31m
Lambert-St Louis
Sat 3/7
8:12 pm-12:08 am
1 stop5h 56m
$251
San DiegoSt. Louis
SAN - STL
SANSTL
San Diego
Mon 4/6
12:44 pm-11:59 pm
1 stop9h 15m
Lambert-St Louis
Fri 4/10
8:16 pm-12:02 am
1 stop5h 46m
$279
San DiegoSt. Louis
SAN - STL
SANSTL
San Diego
Tue 4/21
11:00 am-8:54 pm
1 stop7h 54m
Lambert-St Louis
Fri 4/24
2:40 pm-9:22 pm
1 stop8h 42m
$280
San DiegoSt. Louis
SAN - STL
SANSTL
San Diego
Mon 4/6
10:30 pm-8:25 am
1 stop7h 55m
Lambert-St Louis
Fri 4/10
7:45 am-3:33 pm
1 stop9h 48m
$296
San DiegoSt. Louis
SAN - STL
SANSTL
San Diego
Tue 5/5
11:00 am-8:43 pm
1 stop7h 43m
Lambert-St Louis
Sat 5/16
7:45 am-3:33 pm
1 stop9h 48m
$296
San DiegoSt. Louis
SAN - STL
SANSTL
San Diego
Wed 4/15
11:40 am-12:25 am
2 stops10h 45m
Lambert-St Louis
Mon 4/20
2:20 pm-10:29 pm
2 stops10h 09m
$305
San DiegoSt. Louis
SAN - STL
SANSTL
San Diego
Wed 5/20
11:00 am-8:43 pm
1 stop7h 43m
Lambert-St Louis
Fri 5/22
6:00 am-11:21 am
1 stop7h 21m
$308
Showing 1-10 of 23 results
Compare providers for flights from San Diego to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Diego to St. Louis in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*2 stars | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on San Diego-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Diego-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Diego-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Diego-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Diego-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Diego to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from San Diego with our price prediction graph.
SAN-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Diego to St. Louis
Prices
More
How far ahead should I book a flight from San Diego to St. Louis?
Use this chart to determine the optimal time to book a round-trip flight from San Diego to St. Louis. Price data was last updated on February 20, 2026.
The best time to book flights from San Diego to St. Louis is 75 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from San Diego to St. Louis?
Currently, September is the cheapest month in which you can book a flight from San Diego to St. Louis (average of $71). Flying from San Diego to St. Louis in March is currently the most expensive (average of $226). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SAN to STL?
Find hourly flight availability from San Diego to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated February 21, 2026.
When flying from San Diego to St. Louis, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
What’s the top layover airport for flights from San Diego to St. Louis?
Share of 1-stop round-trip flights from San Diego to St. Louis chosen by Cheapflights users in the past 12 months, using the same layover each way.
Denver (DEN) – chosen by Cheapflights users on 50% of 1-stop itineraries from San Diego to St. Louis on Cheapflights.
What’s the cheapest layover airport for flights from San Diego to St. Louis?
Average round-trip fare for 1-stop flights from San Diego to St. Louis, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Denver (DEN) is the most affordable 1-stop option, with an average round-trip price of $141.
What’s the fastest layover option from San Diego to St. Louis?
Shortest average travel time for 1-stop one-way flights from San Diego to St. Louis, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Las Vegas (LAS) have the shortest average one-way travel time for 1-stop routes: 6h 07m.
Which airport typically offers the quickest layover for flights from San Diego to St. Louis?
Average layover duration for 1-stop one-way flights from San Diego to St. Louis, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Las Vegas (LAS) offer the fastest connection on this route, with an average layover time of 3h 29m.
The best insider tips for San Diego to St. Louis flights
AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your San Diego to St. Louis trip
Our travel experts
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated February 21, 2026.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from San Diego to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Comfort
8.0
Crew
8.6
Boarding
8.1
Overall
8.0
Food
7.0
Entertainment
7.5
Reviews
1 / 20
10.0
ExcellentWilliam Drew,Nov 2025
SJC - HNL
Related info for your journey
Find useful and relevant information for your journey from San Diego to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsEdwardsville
O'Fallon
Swansea
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
Chesterfield
Alton
Farmington
Festus
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Top 5 airlines flying from San Diego to St. Louis
Discover the top 5 airlines that operate flights from San Diego to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 21, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$140 | Average$238 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$184 | Average$277 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$249 | Average$338 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$256 | Average$366 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$306 | Average$486 | FlexibilityNo cancel fee | On-time63% |