$93+ Cheap flights from San Diego to St. Louis (SAN - STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/11. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — STL
Oct 17 — Oct 241
Round-trip
1 adult, Economy
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Find cheap flights from San Diego to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from San Diego to Lambert-St Louis are usually found in August or May, booked 39 days in advance, depart on a Thursday or Wednesday and return on a Thursday
Cheap flight deals from San Diego to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from San Diego to St. LouisExplore the most affordable flight options available from San Diego to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
Explore the most affordable flight options available from San Diego to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2026.
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:25 am -
1 stop6h 58m
Sat 11/147:59 pm -
1 stop5h 58m
Deal found 9/12![Frontier logo]()
$197
This Frontier deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:25 am -
1 stop10h 32m
Sat 10/317:59 pm -
1 stop5h 58m
Deal found 9/16![Frontier logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:25 am -
1 stop6h 58m
Mon 11/167:59 pm -
1 stop21h 59m
Deal found 9/12![Frontier logo]()
$203
This CheapOair deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:53 pm -
1 stop24h 21m
Mon 11/161:28 pm -
1 stop8h 19m
Deal found 9/16![Frontier logo]()
$208
This Frontier deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/19:03 pm -
1 stop12h 14m
Mon 10/58:10 pm -
1 stop5h 41m
Deal found 9/16![Frontier logo]()
$223
This Expedia deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/179:20 am -
1 stop12h 39m
Mon 11/27:59 pm -
1 stop5h 58m
Deal found 9/16![Multiple Airlines logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/146:25 am -
1 stop10h 49m
Mon 11/167:59 pm -
1 stop21h 59m
Deal found 9/12![Frontier logo]()
$234
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/13:15 pm -
1 stop6h 20m
Tue 12/88:00 am -
1 stop6h 15m
Deal found 9/15![American Airlines logo]()
$236
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/144:40 pm -
1 stop5h 15m
Tue 10/205:20 pm -
1 stop6h 05m
Deal found 9/16![Southwest logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:25 am -
1 stop10h 49m
Sat 11/147:59 pm -
1 stop5h 58m
Deal found 9/12![Frontier logo]()
$238
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:25 am -
1 stop6h 58m
Thu 11/191:28 pm -
1 stop8h 19m
Deal found 9/12![Frontier logo]()
$241
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/62:24 pm -
2 stops7h 20m
Tue 10/135:36 pm -
1 stop7h 05m
Deal found 9/16![United Airlines logo]()
$242
Best flights from San Diego to St. LouisDiscover carefully curated flight deals from San Diego to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
Discover carefully curated flight deals from San Diego to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 17, 2026.
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/152:10 pm -
1 stop7h 44m
Mon 10/195:35 pm -
1 stop7h 49m
Deal found 9/16![Delta logo]()
$257
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:40 am -
2 stops7h 25m
Tue 10/274:55 pm -
1 stop6h 05m
Deal found 9/16![Southwest logo]()
$278
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:15 am -
2 stops10h 28m
Mon 11/28:00 am -
1 stop7h 47m
Deal found 9/16![United Airlines logo]()
$358
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/1712:38 pm -
1 stop9h 16m
Mon 11/25:00 pm -
1 stop7h 40m
Deal found 9/16![Delta logo]()
$291
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/131:40 pm -
Nonstop3h 30m
Mon 11/168:30 am -
1 stop5h 20m
Deal found 9/15![Southwest logo]()
$368
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/96:20 am -
2 stops12h 39m
Wed 11/111:40 pm -
2 stops8h 44m
Deal found 9/16![United Airlines logo]()
$401
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/212:33 pm -
1 stop7h 23m
Fri 11/277:08 am -
1 stop7h 16m
Deal found 9/13![Delta logo]()
$373
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/17:41 pm -
2 stops13h 07m
Mon 10/58:00 am -
2 stops11h 26m
Deal found 9/16![United Airlines logo]()
$413
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/61:40 pm -
Nonstop3h 30m
Thu 12/108:35 am -
1 stop6h 25m
Deal found 9/14![Southwest logo]()
$448
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/247:45 am -
2 stops11h 24m
Sat 10/316:21 am -
2 stops10h 43m
Deal found 9/14![Delta logo]()
$413
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/167:41 pm -
2 stops13h 07m
Fri 10/231:29 pm -
2 stops8h 39m
Deal found 9/15![United Airlines logo]()
$427
This Delta deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/116:15 am -
1 stop9h 05m
Sun 12/1312:31 pm -
2 stops12h 21m
Deal found 9/13![Delta logo]()
$420
Last-minute flights from San Diego to St. LouisDiscover last-minute flight deals from San Diego to St. Louis. Data last updated September 17, 2026 and is based on user searches.
Discover last-minute flight deals from San Diego to St. Louis. Data last updated September 17, 2026 and is based on user searches.
This Frontier deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/19:03 pm -
1 stop12h 14m
Mon 10/58:10 pm -
1 stop5h 41m
Deal found 9/16![Frontier logo]()
$223
This Expedia deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/35:54 pm -
1 stop15h 23m
Tue 10/207:02 am -
1 stop8h 21m
Deal found 9/15![Multiple Airlines logo]()
$258
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/62:24 pm -
2 stops7h 20m
Tue 10/135:36 pm -
1 stop7h 05m
Deal found 9/16![United Airlines logo]()
$242
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/109:45 am -
1 stop6h 58m
Thu 10/157:08 am -
1 stop7h 10m
Deal found 9/14![United Airlines logo]()
$257
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/144:40 pm -
1 stop5h 15m
Tue 10/205:20 pm -
1 stop6h 05m
Deal found 9/16![Southwest logo]()
$237
This Expedia deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/154:53 pm -
1 stop24h 22m
Mon 10/191:30 pm -
1 stop8h 19m
Deal found 9/16![Frontier logo]()
$262
This Expedia deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/179:20 am -
1 stop12h 39m
Mon 11/27:59 pm -
1 stop5h 58m
Deal found 9/16![Multiple Airlines logo]()
$233
This Delta deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:15 am -
1 stop7h 22m
Tue 10/207:45 am -
1 stop6h 40m
Deal found 9/14![Delta logo]()
$247
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/212:24 pm -
2 stops7h 20m
Mon 10/267:05 pm -
1 stop7h 14m
Deal found 9/15![United Airlines logo]()
$252
This Southwest deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/224:25 pm -
1 stop5h 30m
Wed 10/288:30 am -
Nonstop3h 55m
Deal found 9/16![Southwest logo]()
$260
This Frontier deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:25 am -
1 stop10h 32m
Sat 10/317:59 pm -
1 stop5h 58m
Deal found 9/16![Frontier logo]()
$198
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/274:53 pm -
1 stop20h 30m
Fri 10/307:59 pm -
1 stop21h 59m
Deal found 9/12![Frontier logo]()
$246
One-way flights from San Diego to St. LouisSearch for one-way flight options from San Diego to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
Search for one-way flight options from San Diego to St. Louis. Find affordable one-way fares based on user searches. Data last updated September 17, 2026.
This Priceline deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:25 am -
1 stop6h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![Frontier logo]()
$93
This Frontier deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/166:25 am -
1 stop10h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Frontier logo]()
$95
This Frontier deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/146:25 am -
1 stop10h 29m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Frontier logo]()
$105
This Kiwi.com deal was found by Cheapflights users on 9/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/104:53 pm -
1 stop20h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/12![Frontier logo]()
$106
This Southwest deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:30 am -
1 stop5h 20m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Southwest logo]()
$114
This Super.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/166:25 am -
1 stop10h 50m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/17![Frontier logo]()
$118
This Delta deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/135:01 pm -
1 stop5h 43m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![Delta logo]()
$119
This Southwest deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/55:20 pm -
1 stop5h 15m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/14![Southwest logo]()
$124
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/174:53 pm -
2 stops22h 47m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/15![Frontier logo]()
$125
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/102:07 pm -
1 stop6h 51m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 9/16![United Airlines logo]()
$129
Find flight deals from San Diego to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $195 (CheapOair) |
One-way from | $93 (Priceline) |
Popular in | December |
Cheapest in | August |
Average price | $406 |
Good round-trip deal | $506 or less |
Good one-way deal | $288 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from San Diego to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
Use the filters below to find and compare flights from San Diego to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Wed 10/14
5:01 pm-12:44 am
1 stop5h 43m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$119
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Tue 11/17
2:33 pm-11:56 pm
1 stop7h 23m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$119
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Tue 12/15
9:20 am-6:35 pm
2 stops7h 15m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$124
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Thu 11/12
6:15 am-5:14 pm
1 stop8h 59m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$129
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Fri 10/2
9:03 pm-11:32 am
1 stop12h 29m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$130
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Thu 12/17
6:15 am-5:20 pm
1 stop9h 05m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$146
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Tue 12/15
3:00 pm-11:26 pm
1 stop6h 26m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$146
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Mon 10/19
10:25 pm-9:09 am
1 stop8h 44m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$174
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Mon 1/4
6:15 am-6:01 pm
1 stop9h 46m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$174
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Mon 11/9
9:40 pm-3:43 pm
2 stops16h 03m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$184
Showing 1-10 of 24 resultsSorted by cheapest first
Compare providers for flights from San Diego to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Diego to St. Louis in September.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*1 star |
- Most accurate provider: When it comes to deals on San Diego-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Diego-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Diego-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Diego-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Diego-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Diego to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from San Diego with our price prediction graph.
SAN-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Diego to St. Louis
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How far ahead should I book a flight from San Diego to St. Louis?
The best time to book flights from San Diego to St. Louis is 38 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from San Diego to St. Louis?
Currently, August is the cheapest month in which you can book a flight from San Diego to St. Louis (average of $332). Flying from San Diego to St. Louis in December is currently the most expensive (average of $492). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SAN to STL?
Find hourly flight availability from San Diego to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2026.
When flying from San Diego to St. Louis, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
What’s the top layover airport for flights from San Diego to St. Louis?
Share of 1-stop round-trip flights from San Diego to St. Louis chosen by Cheapflights users in the past 12 months, using the same layover each way.
Denver (DEN) – chosen by Cheapflights users on 50% of 1-stop itineraries from San Diego to St. Louis on Cheapflights.
What’s the cheapest layover airport for flights from San Diego to St. Louis?
Average round-trip fare for 1-stop flights from San Diego to St. Louis, chosen by Cheapflights users in the past 12 months, with the same layover each way.
Las Vegas (LAS) is the most affordable 1-stop option, with an average round-trip price of $203.
What’s the fastest layover option from San Diego to St. Louis?
Shortest average travel time for 1-stop one-way flights from San Diego to St. Louis, based on itineraries clicked by Cheapflights users over the past 12 months, grouped by layover airport.
Flights via Las Vegas (LAS) have the shortest average one-way travel time for 1-stop routes: 6h 07m.
Which airport typically offers the quickest layover for flights from San Diego to St. Louis?
Average layover duration for 1-stop one-way flights from San Diego to St. Louis, chosen by Cheapflights users in the last 12 months, grouped by stopover airport.
Flights via Denver (DEN) offer the fastest connection on this route, with an average layover time of 3h 24m.
The best insider tips for San Diego to St. Louis flights
AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your San Diego to St. Louis trip
Our travel experts
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated September 17, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from San Diego to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Overall
8.0
Food
7.0
Boarding
8.1
Comfort
8.0
Entertainment
7.5
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Related info for your journey
Find useful and relevant information for your journey from San Diego to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsFairview Heights
O'Fallon
Fenton
Swansea
Eureka
Maryland Heights
Collinsville
Wentzville
Edwardsville
Glencoe
Chesterfield
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San Diego and St. Louis flights
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Top 7 airlines flying from San Diego to St. Louis
Discover the top 7 airlines that operate flights from San Diego to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated September 17, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$91 | Average$375 | FlexibilityNo cancel fee | On-time75% | |
| Cheapest$140 | Average$281 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$209 | Average$386 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$236 | Average$347 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$236 | Average$418 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$236 | Average$368 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$296 | Average$477 | FlexibilityNo cancel fee | On-time63% |