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St. Louis

$72+ Cheap flights from San Diego to St. Louis (SAN - STL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/13. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — STL
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheapflights Tip: The best prices from San Diego to Lambert-St Louis are usually found in September or February, booked 69 days in advance, depart on a Thursday or Tuesday and return on a Tuesday

Cheap flight deals from San Diego to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$144
(Frontier)

One-way from

$72
(Priceline)

Popular in

December

Cheapest in

September

Average price

$288

Good round-trip deal

$296 or less

Good one-way deal

$228 or less
From San Diego to Lambert-St Louis
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One-way flight from San Diego to Lambert-St Louis
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Highest demand for flights based on searches. 6% potential increase in price ($26 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($7 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from San Diego to Lambert-St Louis.
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Price to beat on a one-way flight from San Diego to Lambert-St Louis.
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Find flight deals from San Diego to St. Louis

Cheapest flights from San Diego to St. Louis
Explore the most affordable flight options available from San Diego to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Frontier deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:11 amSAN - STL
1 stop12h 03mFrontier
Wed 10/227:52 pmSTL - SAN
1 stop5h 58mFrontier
Deal found 9/16$144
This Booking.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/237:15 amSAN - STL
1 stop23h 51mFrontier
Thu 9/2510:49 amSTL - SAN
1 stop8h 53mFrontier
Deal found 9/15$145
This Booking.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/237:15 amSAN - STL
1 stop23h 51mFrontier
Fri 9/269:35 pmSTL - SAN
1 stop22h 55mFrontier
Deal found 9/17$146
This Frontier deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/29:03 pmSAN - STL
1 stop10h 03mFrontier
Sun 10/510:39 amSTL - SAN
1 stop8h 03mFrontier
Deal found 9/16$157
This Booking.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/266:25 amSAN - STL
1 stop5h 28mFrontier
Sun 9/287:55 pmSTL - SAN
1 stop17h 14mFrontier
Deal found 9/16$159
This Frontier deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/178:11 amSAN - STL
1 stop12h 03mFrontier
Sat 10/184:51 pmSTL - SAN
1 stop6h 00mFrontier
Deal found 9/16$177
This Booking.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/237:15 amSAN - STL
1 stop23h 51mFrontier
Tue 9/307:55 pmSTL - SAN
1 stop28h 29mFrontier
Deal found 9/17$179
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/1111:11 amSAN - STL
1 stop7h 46mUnited Airlines
Tue 12/161:35 pmSTL - SAN
1 stop5h 59mUnited Airlines
Deal found 9/14$183
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/811:02 amSAN - STL
2 stops8h 52mUnited Airlines
Mon 11/104:43 pmSTL - SAN
1 stop6h 11mUnited Airlines
Deal found 9/15$188
This Frontier deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/188:00 amSAN - STL
1 stop5h 56mFrontier
Wed 10/227:52 pmSTL - SAN
1 stop5h 58mFrontier
Deal found 9/16$190
This Booking.com deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/166:25 amSAN - STL
1 stop27h 18mFrontier
Sun 10/1910:17 amSTL - SAN
1 stop10h 11mFrontier
Deal found 9/17$192
This Kiwi.com deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/179:03 pmSAN - STL
1 stop10h 04mFrontier
Mon 10/207:52 pmSTL - SAN
2 stops27h 28mFrontier
Deal found 9/15$198

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from San Diego to St. Louis that are best for you.

Fly from

San Diego

Fly to

St. Louis

Route

Depart

Return

Price

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Tue 9/23

7:15 am-9:06 am

1 stop23h 51m

Lambert-St Louis

Thu 9/25

10:49 am-5:42 pm

1 stop8h 53m

$145

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Wed 10/8

6:41 am-9:07 am

1 stop24h 26m

Lambert-St Louis

Fri 10/10

7:52 pm-10:25 pm

1 stop28h 33m

$145

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Tue 9/23

7:15 am-9:06 am

1 stop23h 51m

Lambert-St Louis

Fri 9/26

9:35 pm-6:30 pm

1 stop22h 55m

$146

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Thu 10/2

9:03 pm-9:06 am

1 stop10h 03m

Lambert-St Louis

Sun 10/5

10:39 am-4:42 pm

1 stop8h 03m

$157

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Tue 10/14

6:41 am-9:07 am

1 stop24h 26m

Lambert-St Louis

Sat 10/18

4:51 pm-8:51 pm

1 stop6h 00m

$179

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Wed 10/15

6:41 am-9:07 am

1 stop24h 26m

Lambert-St Louis

Wed 10/22

7:52 pm-11:50 pm

1 stop5h 58m

$179

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Tue 12/9

9:37 am-7:29 pm

1 stop7h 52m

Lambert-St Louis

Thu 12/11

8:41 am-2:16 pm

1 stop7h 35m

$183

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Sat 11/8

11:02 am-9:54 pm

2 stops8h 52m

Lambert-St Louis

Mon 11/10

4:43 pm-8:54 pm

1 stop6h 11m

$188

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Sun 12/14

6:25 am-10:02 am

1 stop25h 37m

Lambert-St Louis

Wed 12/17

7:43 pm-8:05 am

1 stop14h 22m

$188

San DiegoSt. Louis

SAN - STL

SANSTL

San Diego

Mon 11/3

5:47 pm-9:07 am

1 stop13h 20m

Lambert-St Louis

Thu 11/6

2:42 pm-9:30 am

1 stop20h 48m

$192

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/17

Showing 1-10 of 24 results
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The best insider tips for San Diego to St. Louis flights

Snippets provided in this section are AI-generated based on a summarization of Cheapflights-commissioned articles. The articles are presented as-is, for general informational purposes only, and may not be up-to-date. The opinions contained in the articles are original to the author and reflect their authentic experience, which may vary significantly from the experience of others.
Cheapflights partnered with top experts to bring you the best recommendations for your San Diego to St. Louis trip
Airports
SAN

Plan to arrive at SAN at least two hours before your flight to avoid stress from traffic congestion near the airport.

Read more about SANby Blane Bachelor
STL

Use the MetroLink light rail for a convenient and economical way to reach downtown St. Louis from STL.

Read more about STLby Taryn White
Our travel experts
Blane Bachelor

Blane Bachelor

Expert on SAN

Blane Bachelor

Blane Bachelor

Blane Bachelor is a journalist and editor specializing in travel and aviation who writes regularly for top global outlets. Born and raised in Florida, Blane has worked and lived in four countries, including the Netherlands, where she’s currently based with her family. Her favorite way to get to know a new destination is by running or riding a bike around town – or hearing a spooky ghost story about local history. She will always choose the window seat.

Read more
Taryn White

Taryn White

Expert on STL

Taryn White

Taryn White

Taryn White is a freelance travel writer, digital creator, and travel advisor who has visited nearly 100 countries and all 50 states. She’s familiar with many airports and enjoys beach hopping, boutique hotels, spa experiences, and exploring local culture. Her work has appeared in Travel + Leisure, Condé Nast Traveler, National Geographic, Smithsonian Magazine, AFAR, and more.

Read more

Best time to book a flight from San Diego to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to St. Louis

How far ahead should I book a flight from San Diego to St. Louis?

Use this chart to determine the optimal time to book a round-trip flight from San Diego to St. Louis. Price data was last updated on September 12, 2025.

The best time to book flights from San Diego to St. Louis is 69 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from San Diego to St. Louis?

Currently, August is the cheapest month in which you can book a flight from San Diego to St. Louis (average of $311). Flying from San Diego to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAN to STL?

Find hourly flight availability from San Diego to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

A simple way to save on the total cost of your ticket is to fly from San Diego to St. Louis in the evening. If you’re flexible enough to do this you can expect to save up to 61% on your trip compared to booking a flight at noon.

What is the cheapest day to fly from San Diego to St. Louis?

Use this chart to determine the cheapest time to fly round-trip from San Diego to St. Louis. Price data was last updated on September 14, 2025.

Travelers seeking maximum savings on their San Diego to St. Louis flight should consider departing on Wednesday evenings when fares are most often at their lowest. Friday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated September 17, 2025.
Peruse reviews from past customers who have flown with Southwest, Delta, and United Airlines from San Diego to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
8.0
Very good
7,961 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
8,926 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Frontier
5.8
Fair
3,173 reviews
Southwest
8.0
Very good
4,242 reviews

Boarding

8.1

Crew

8.6

Overall

8.0

Food

7.0

Entertainment

7.5

Comfort

8.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from San Diego to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from San Diego to St. Louis?

    To fly from San Diego to St. Louis, you need to book a flight from San Diego (SAN) to Lambert-St Louis (STL). Nonstop flights to Lambert-St Louis from San Diego take 3h 30m on average. When it comes time to book airfare, you have a few options: there is 1 outbound flight from San Diego to Lambert-St Louis offered by 5 different airlines.

  • How popular is this San Diego to St. Louis flight route?

    Flights from San Diego to Lambert-St Louis have been viewed 8 times in the past calendar month.

  • How long is the flight from San Diego to St. Louis?

    Airlines like Frontier fly from San Diego to St. Louis in about 23h 51m. The time it takes to get you to your destination can typically vary by up to . San Diego and St. Louis are separated by a distance of 1553 mi.

  • What are the cheapest airlines flying from San Diego to St. Louis round-trip?

    Cheapflights users have booked flights from San Diego to St. Louis round-trip from $117. Other airlines that can offer you cheap pricing are Delta, from $184, and American Airlines, from $249. Frontier is priced at 68% lower than the current average price of a flight leaving 3 months from now.

  • What are the cheapest flights from San Diego to St. Louis?

    Looking for the cheapest flight from San Diego to St. Louis? While on average our users pay $360, our data indicates the cheapest price to be $198. The most popular route (San Diego - Lambert-St Louis), is priced around $145.

  • Where are the most common layover locations when flying from San Diego to St. Louis?

    Of the flights from San Diego to St. Louis that have layovers, most of them stop in Phoenix.

  • What are some popular things to do or see while on a layover in Phoenix?

    Chase Field, Desert Ridge Marketplace, and Heritage Square are currently the most popular points of interest in Phoenix at the moment. Those on a layover in Phoenix interested in visiting Chase Field, Desert Ridge Marketplace, or Heritage Square can do so by traveling 4.0 mi, 16.7 mi, and 4.0 mi, respectively from Phoenix Sky Harbor Intl. Travelers can book a car rental at Phoenix Sky Harbor Intl for about $53 per day to make their sightseeing more efficient.

  • Where are the least popular layover locations for San Diego to St. Louis flights?

    San Diego to St. Louis flights have a layover in Denver the least frequently.

  • Can I find deals for flights from San Diego to St. Louis that include hotel bookings?

    Yes. In addition to deals on San Diego to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to St. Louis.

  • Can I find deals for business class flights from San Diego to St. Louis?

    Yes. Cheapflights offers flight deals from San Diego to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to St. Louis?

    Currently, August is the cheapest month in which you can book a flight from San Diego to St. Louis (average of $311). Flying from San Diego to St. Louis in March is currently the most expensive (average of $356). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near St. Louis?

Book flights to St. Louis if you plan to visit one of these locations
Edwardsville
O'Fallon
Fairview Heights
Maryland Heights
Collinsville
Eureka
Glencoe
St. Peters
Chesterfield
Alton
Farmington
Festus

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Top 5 airlines flying from San Diego to St. Louis

Discover the top 5 airlines that operate flights from San Diego to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
FrontierCheapest$117Average$299FlexibilityNo cancel feeOn-time62%
DeltaCheapest$184Average$281FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$249Average$336FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$256Average$366FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$325Average$491FlexibilityNo cancel feeOn-time63%

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