$93+ Cheap flights from San Diego to St. Louis (SAN - STL)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/4. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — STL
Nov 18 — Nov 251
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from San Diego to St. Louis with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from San Diego to Lambert-St Louis are usually found in August or May, booked 75 days in advance, depart on a Wednesday or Thursday and return on a Saturday
Cheap flight deals from San Diego to St. Louis
Cheapest
Best
Last-minute
One-way
Cheapest flights from San Diego to St. LouisExplore the most affordable flight options available from San Diego to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 19, 2026.
Explore the most affordable flight options available from San Diego to St. Louis. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 19, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:53 pm -
1 stop24h 21m
Mon 11/167:59 pm -
1 stop21h 59m
Deal found 10/15![Frontier logo]()
$193
This Expedia deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:25 am -
1 stop10h 49m
Mon 11/167:59 pm -
1 stop21h 59m
Deal found 10/15![Frontier logo]()
$195
This Cheapflightsfares deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/54:53 pm -
1 stop24h 21m
Mon 11/97:59 pm -
1 stop21h 59m
Deal found 10/14![Frontier logo]()
$203
This Kiwi.com deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/36:30 am -
1 stop26h 27m
Wed 12/97:54 pm -
1 stop16h 25m
Deal found 10/17![Frontier logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/1511:14 am -
1 stop21h 50m
Fri 1/17:49 pm -
1 stop6h 39m
Deal found 10/14![Frontier logo]()
$216
This Cheapflightsfares deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/196:36 am -
1 stop6h 50m
Mon 1/44:21 pm -
1 stop26h 18m
Deal found 10/16![Frontier logo]()
$220
This Cheapflightsfares deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:16 am -
1 stop21h 41m
Mon 12/77:54 pm -
1 stop16h 25m
Deal found 10/16![Frontier logo]()
$233
This Trip.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/16:30 am -
1 stop26h 36m
Mon 12/77:54 pm -
1 stop16h 25m
Deal found 10/16![Frontier logo]()
$241
Best flights from San Diego to St. LouisDiscover carefully curated flight deals from San Diego to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 19, 2026.
Discover carefully curated flight deals from San Diego to St. Louis that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 19, 2026.
This Southwest deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/211:55 am -
Nonstop3h 30m
Sat 12/57:00 am -
1 stop6h 25m
Deal found 10/15![Southwest logo]()
$355
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1310:30 pm -
1 stop9h 16m
Mon 11/162:20 pm -
2 stops10h 34m
Deal found 10/15![Delta logo]()
$408
This Alaska Airlines deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Alaska Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/135:20 pm -
2 stops14h 10m
Tue 11/178:29 am -
2 stops13h 58m
Deal found 10/14![Alaska Airlines logo]()
$472
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1611:55 am -
Nonstop3h 30m
Fri 1/15:05 am -
1 stop6h 50m
Deal found 10/14![Southwest logo]()
$356
This Delta deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/73:00 pm -
1 stop6h 26m
Sat 12/1211:44 am -
2 stops13h 08m
Deal found 10/18![Delta logo]()
$456
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/158:20 am -
2 stops7h 05m
Fri 1/112:40 pm -
2 stops6h 45m
Deal found 10/14![Southwest logo]()
$435
This Delta deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1910:35 pm -
1 stop9h 30m
Mon 1/42:15 pm -
2 stops10h 34m
Deal found 10/15![Delta logo]()
$498
This Southwest deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/311:55 am -
Nonstop3h 30m
Wed 12/98:25 am -
Nonstop3h 55m
Deal found 10/17![Southwest logo]()
$469
This Southwest deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/196:45 am -
Nonstop3h 35m
Fri 1/15:05 am -
1 stop6h 50m
Deal found 10/14![Southwest logo]()
$521
This Southwest deal was found by Cheapflights users on 10/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/167:10 am -
1 stop7h 35m
Mon 11/238:50 am -
Nonstop4h 00m
Deal found 10/17![Southwest logo]()
$532
Last-minute flights from San Diego to St. LouisDiscover last-minute flight deals from San Diego to St. Louis. Data last updated October 19, 2026 and is based on user searches.
Discover last-minute flight deals from San Diego to St. Louis. Data last updated October 19, 2026 and is based on user searches.
This Cheapflightsfares deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:25 am -
1 stop10h 49m
Wed 11/44:18 pm -
1 stop9h 39m
Deal found 10/16![Frontier logo]()
$259
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:25 am -
1 stop6h 58m
Wed 11/46:44 pm -
2 stops39h 53m
Deal found 10/14![Frontier logo]()
$248
This Cheapflightsfares deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals ”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/54:53 pm -
1 stop24h 21m
Mon 11/97:59 pm -
1 stop21h 59m
Deal found 10/14![Frontier logo]()
$203
This Cheapflightsfares deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/124:53 pm -
1 stop24h 21m
Mon 11/167:59 pm -
1 stop21h 59m
Deal found 10/15![Frontier logo]()
$193
This Expedia deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:25 am -
1 stop10h 49m
Mon 11/167:59 pm -
1 stop21h 59m
Deal found 10/15![Frontier logo]()
$195
This Cheapflightsfares deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/196:25 am -
1 stop26h 38m
Mon 11/233:04 pm -
1 stop10h 53m
Deal found 10/14![Frontier logo]()
$267
One-way flights from San Diego to St. LouisSearch for one-way flight options from San Diego to St. Louis. Find affordable one-way fares based on user searches. Data last updated October 19, 2026.
Search for one-way flight options from San Diego to St. Louis. Find affordable one-way fares based on user searches. Data last updated October 19, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/46:25 am -
1 stop6h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Frontier logo]()
$93
This Super.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/156:30 am -
1 stop26h 34m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Frontier logo]()
$97
This Booking.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/174:53 pm -
1 stop20h 30m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Frontier logo]()
$98
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/116:25 am -
1 stop6h 58m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Frontier logo]()
$99
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:25 am -
1 stop10h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Frontier logo]()
$105
This Cheapflightsfares deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:30 am -
1 stop26h 33m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Frontier logo]()
$106
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/125:26 pm -
1 stop14h 54m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Frontier logo]()
$107
This Super.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/166:25 am -
1 stop10h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Frontier logo]()
$116
This Kiwi.com deal was found by Cheapflights users on 10/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/156:36 am -
1 stop25h 44m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/14![Frontier logo]()
$118
This Mytrip deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/128:20 pm -
2 stops12h 59m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/15![Frontier logo]()
$120
Find flight deals from San Diego to St. Louis
Discover tips and strategies to find the most affordable flight options for your journey from San Diego (SAN) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 19, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $193 (Cheapflightsfares) |
One-way from | $93 (Cheapflightsfares) |
Popular in | December |
Cheapest in | August |
Average price | $410 |
Good round-trip deal | $496 or less |
Good one-way deal | $198 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from San Diego to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 19, 2026.
Use the filters below to find and compare flights from San Diego to St. Louis that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Mon 11/9
7:38 pm-3:23 pm
2 stops41h 45m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$162
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Mon 12/14
6:30 am-1:50 pm
1 stop5h 20m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$175
Quickest round-trip
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Fri 1/15
12:35 pm-6:00 pm
Nonstop3h 25m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$250
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Thu 12/17
1:40 pm-7:10 pm
Nonstop3h 30m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$250
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Thu 12/17
6:20 am-5:00 pm
2 stops8h 40m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$255
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Thu 12/17
7:56 pm-3:26 pm
2 stops41h 30m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$263
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Mon 11/9
1:40 pm-7:10 pm
Nonstop3h 30m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$270
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Thu 11/12
1:40 pm-7:10 pm
Nonstop3h 30m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$271
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Fri 11/27
6:15 am-8:59 pm
2 stops12h 44m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$285
San DiegoSt. Louis
SAN San Diego - STL Lambert-St Louis
SANSTL
San Diego
Thu 11/26
6:45 am-6:38 pm
2 stops9h 53m
Lambert-St Louis
Wed 12/31
12:00 am-10:00 pm
Nonstop0h 00m
$285
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from San Diego to St. Louis
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from San Diego to St. Louis in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on San Diego-St. Louis flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on San Diego-St. Louis flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from San Diego-St. Louis flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on San Diego-St. Louis flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for San Diego-St. Louis flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from San Diego to St. Louis
Have a flexible travel schedule? Discover the best time to fly to St. Louis from San Diego with our price prediction graph.
SAN-STL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from San Diego to St. Louis
How far ahead should I book a flight from San Diego to St. Louis?
The best time to book flights from San Diego to St. Louis is 74 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from San Diego to St. Louis?
Currently, August is the cheapest month in which you can book a flight from San Diego to St. Louis (average of $332). Flying from San Diego to St. Louis in December is currently the most expensive (average of $506). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from SAN to STL?
Find hourly flight availability from San Diego to St. Louis. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 19, 2026.
When flying from San Diego to St. Louis, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
The best insider tips for San Diego to St. Louis flights
AI-powered summary based on content written by travel experts. AI can make mistakes.
Cheapflights partnered with top experts to bring you the best recommendations for your San Diego to St. Louis trip
Our travel experts
Reviews of airlines servicing St. Louis
Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated October 19, 2026.
Peruse reviews from past customers who have flown with Southwest,Delta, andUnited Airlines from San Diego to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.4
Overall
7.9
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.4
Overall
7.9
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.4
Overall
7.9
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.4
Overall
7.9
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.4
Overall
7.9
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Food
7.0
Comfort
8.0
Boarding
8.1
Entertainment
7.4
Overall
7.9
Crew
8.6
Reviews
1 / 20
10.0
ExcellentCourtney,Sep 2026
DEN - STL
Related info for your journey
Find useful and relevant information for your journey from San Diego to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near St. Louis?
Book flights to St. Louis if you plan to visit one of these locationsFairview Heights
O'Fallon
Fenton
Swansea
Eureka
Wentzville
Maryland Heights
Chesterfield
Collinsville
Edwardsville
Glencoe
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from San Diego
Popular flights
St. Louis flight routes
Alternative routes for San Diego to St. Louis
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to St. Louis by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from San Diego to St. Louis by cabin class
Find flights from San Diego to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
San Diego and St. Louis flights
Browse other San Diego and St. Louis flight options. Last updated on October 19, 2026.
Other flights from San Diego
Browse through other flights departing from San Diego. Flights are based on user searches made on Cheapflights and were last updated on October 19, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to St. Louis
Explore flights to St. Louis departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on October 19, 2026.
Top 7 airlines flying from San Diego to St. Louis
Discover the top 7 airlines that operate flights from San Diego to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 19, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$91 | Average$375 | FlexibilityNo cancel fee | On-time75% | |
| Cheapest$140 | Average$283 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$209 | Average$386 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$236 | Average$374 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$236 | Average$362 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$236 | Average$383 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$296 | Average$504 | FlexibilityNo cancel fee | On-time63% |