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Spartanburg

$98+ Cheap flights from Knoxville (TYS) to Spartanburg, SC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/17. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CLT
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Knoxville to Spartanburg

Cheapest flights from Knoxville to Spartanburg
Explore the most affordable flight options available from Knoxville to Spartanburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:00 amTYS - CLT
1 stop7h 56mMultiple Airlines
Wed 12/319:38 pmCLT - TYS
2 stops36h 37mMultiple Airlines
Deal found 12/16$394
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/194:22 pmTYS - CLT
1 stop43h 39mAmerican Airlines
Sun 12/213:29 pmCLT - TYS
Nonstop1h 15mAmerican Airlines
Deal found 12/16$408
This Kiwi.com deal was found by Cheapflights users on 12/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/225:38 pmTYS - CLT
1 stop19h 59mMultiple Airlines
Wed 12/249:04 pmCLT - TYS
2 stops18h 12mMultiple Airlines
Deal found 12/18$409
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/195:38 pmTYS - CLT
1 stop21h 23mMultiple Airlines
Sun 12/219:34 pmCLT - TYS
1 stop24h 19mMultiple Airlines
Deal found 12/16$437
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/172:53 pmTYS - CLT
1 stop18h 46mMultiple Airlines
Sun 12/219:33 pmCLT - TYS
1 stop24h 20mMultiple Airlines
Deal found 12/15$517
This American Airlines deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/1712:02 pmTYS - CLT
Nonstop1h 22mAmerican Airlines
Sun 12/216:30 pmCLT - TYS
Nonstop1h 11mAmerican Airlines
Deal found 12/15$519
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/2910:09 amTYS - CLT
Nonstop1h 24mAmerican Airlines
Wed 12/319:29 amCLT - TYS
1 stop31h 09mAmerican Airlines
Deal found 12/16$643

Find flight deals from Knoxville to Spartanburg

Keep the following information in mind while searching for Knoxville to Spartanburg flight deals. Data was last updated December 18, 2025.

Most accurate provider

Mytrip
3 stars

Most trusted provider

Mytrip
3 stars

Round-trip from

$203
(Kiwi.com)

One-way from

$98
(Kiwi.com)

Popular in

June

Cheapest in

April

Average price

$656
Provider with most accurate pricing for Knoxville McGhee Tyson-Charlotte Douglas flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Charlotte Douglas flights.
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From Knoxville McGhee Tyson to Spartanburg
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One-way flight from Knoxville McGhee Tyson to Spartanburg
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Highest demand for flights based on searches. 6% potential increase in price ($42 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($22 potential savings vs. average RT price).
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Average for round-trip flights in December 2025
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Spartanburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Knoxville to Spartanburg that are best for you.

Fly from

Knoxville

Fly to

Spartanburg

Route

Depart

Return

Price

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Mon 2/23

12:55 pm-1:51 pm

1 stop24h 56m

Charlotte Douglas

Thu 2/26

1:17 pm-10:11 pm

1 stop8h 54m

$203

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Thu 1/29

9:29 am-6:48 pm

1 stop9h 19m

Charlotte Douglas

Sat 1/31

9:50 pm-11:05 pm

2 stops25h 15m

$231

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Mon 2/23

7:15 am-2:17 pm

1 stop7h 02m

Charlotte Douglas

Wed 2/25

1:24 pm-2:35 pm

1 stop25h 11m

$240

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Mon 2/23

7:22 pm-11:54 pm

2 stops28h 32m

Charlotte Douglas

Fri 2/27

8:53 am-4:59 pm

1 stop8h 06m

$252

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Tue 3/24

3:00 pm-2:17 pm

1 stop23h 17m

Charlotte Douglas

Thu 3/26

2:37 pm-10:59 pm

1 stop8h 22m

$273

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Sat 1/3

2:23 pm-8:39 pm

2 stops30h 16m

Charlotte Douglas

Sat 1/10

7:43 pm-8:39 am

1 stop12h 56m

$285

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Mon 12/29

6:00 am-1:56 pm

1 stop7h 56m

Charlotte Douglas

Wed 12/31

9:38 pm-10:15 am

2 stops36h 37m

$394

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Thu 3/19

11:15 am-6:40 am

1 stop19h 25m

Charlotte Douglas

Sun 3/22

10:36 pm-3:32 pm

1 stop16h 56m

$462

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Wed 2/18

3:52 pm-11:56 pm

1 stop8h 04m

$103

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Tue 2/17

4:04 pm-8:26 am

1 stop16h 22m

$118

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 14 results
1
2

Best time to book a flight from Knoxville to Spartanburg

Have a flexible travel schedule? Discover the best time to fly to Spartanburg from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Spartanburg

What is the cheapest month to book a flight from Knoxville to Spartanburg?

Currently, November is the cheapest month in which you can book a flight from Knoxville to Spartanburg (average of $243). Flying from Knoxville to Spartanburg in October is currently the most expensive (average of $388). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SB1?

Find hourly flight availability from Knoxville to Spartanburg. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

When flying from Knoxville to Spartanburg, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 70% versus a flight at noon.

What is the cheapest day to fly from Knoxville to Spartanburg?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Spartanburg. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to Spartanburg flight should consider departing on Monday evenings when fares are most often at their lowest. Friday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Knoxville to Spartanburg?

Reviews of airlines servicing Spartanburg

Get insights into the airlines that provide service to Spartanburg. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spartanburg. Reviews last updated December 18, 2025.
Read through reviews of airlines operating flights from Knoxville to Spartanburg, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,055 reviews

Crew

8.0

Food

6.5

Overall

7.2

Comfort

7.2

Boarding

7.5

Entertainment

6.9

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit
American Airlines
7.2
Good
11,055 reviews
American Airlines
7.2
Good
11,055 reviews

Crew

8.0

Food

6.5

Overall

7.2

Comfort

7.2

Boarding

7.5

Entertainment

6.9

Reviews

1 / 20
10.0
Excellent

Jeremy,Dec 2025

OKC - CLT

Was an okay flight. Had extra seat empty beside me so was able to stretch a bit

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Spartanburg. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Spartanburg?

    If you book a flight to Spartanburg from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 2 flights from McGhee Tyson to Spartanburg per day from 2 different airlines.

  • How popular is this Knoxville to Spartanburg flight route?

    The Knoxville McGhee Tyson to Spartanburg flight path was viewed by 2 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the most reliable airlines from Knoxville to Spartanburg?

    Before booking your flight to Spartanburg from Knoxville, check out the most reliable airlines to get you to your destination on time: Envoy Air (100%), PSA Airlines (88%), American Airlines( 86%).

  • What are the cheapest flights from Knoxville to Spartanburg?

    The cheapest flight price from Knoxville to Spartanburg is $125. On average you can expect to pay $583. The most popular route, (Knoxville McGhee Tyson - Charlotte Douglas), can usually be booked for $203.

  • Can I find deals for flights from Knoxville to Spartanburg that include hotel bookings?

    Yes. In addition to deals on Knoxville to Spartanburg flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Spartanburg?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Spartanburg.

  • Can I find deals for business class flights from Knoxville to Spartanburg?

    Yes. Cheapflights offers flight deals from Knoxville to Spartanburg by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Spartanburg?

    Currently, November is the cheapest month in which you can book a flight from Knoxville to Spartanburg (average of $243). Flying from Knoxville to Spartanburg in October is currently the most expensive (average of $388). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 2 airlines flying from Knoxville to Spartanburg

Discover the top 2 airlines that operate flights from Knoxville to Spartanburg. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$286Average$334FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$296Average$448FlexibilityNo cancel feeOn-time71%

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