HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Spartanburg

$114+ Cheap flights from Knoxville (TYS) to Spartanburg, SC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/22. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CLT
Aug 4 — Aug 111
Mon 8/4
Mon 8/11
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Spartanburg with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Spartanburg

Keep the following information in mind while searching for Knoxville to Spartanburg flight deals. Data was last updated July 30, 2025.

Round-trip from

$190
(Mytrip)

One-way from

$114
(Mytrip)

Popular in

June

Cheapest in

April

Average price

$549
From Knoxville McGhee Tyson to Spartanburg
Search Deals
One-way flight from Knoxville McGhee Tyson to Spartanburg
Search Deals
Highest demand for flights based on searches. 9% potential increase in price ($61 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2025
Search Deals

Find flight deals from Knoxville to Spartanburg

Cheapest flights from Knoxville to Spartanburg
Explore the most affordable flight options available from Knoxville to Spartanburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 30, 2025.

This Mytrip deal was found by Cheapflights users on 7/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/1812:08 pmTYS - CLT
1 stop9h 51mMultiple Airlines
Mon 9/226:00 amCLT - TYS
1 stop10h 37mMultiple Airlines
Deal found 7/30$225
This American Airlines deal was found by Cheapflights users on 7/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/265:19 pmTYS - CLT
1 stop15h 18mAmerican Airlines
Tue 9/210:05 pmCLT - TYS
1 stop18h 44mAmerican Airlines
Deal found 7/29$355

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Spartanburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
Use the filters below to find and compare flights from Knoxville to Spartanburg that are best for you.

Fly from

Knoxville

Fly to

Spartanburg

Route

Depart

Return

Price

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Thu 9/18

12:08 pm-9:59 pm

1 stop9h 51m

Charlotte Douglas

Mon 9/22

6:00 am-4:37 pm

1 stop10h 37m

$225

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Tue 8/26

5:19 pm-8:37 am

1 stop15h 18m

Charlotte Douglas

Tue 9/2

10:05 pm-4:49 pm

1 stop18h 44m

$355

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Fri 8/22

1:22 pm-10:25 pm

1 stop9h 03m

$114

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Fri 9/26

7:11 pm-9:16 am

2 stops14h 05m

$175

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Fri 8/29

10:36 am-4:59 pm

1 stop30h 23m

$183

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Sat 10/25

9:55 am-10:02 am

1 stop24h 07m

$249

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/29

Best time to book a flight from Knoxville to Spartanburg

Have a flexible travel schedule? Discover the best time to fly to Spartanburg from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Spartanburg

What is the cheapest month to book a flight from Knoxville to Spartanburg?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Spartanburg (average of $248). Flying from Knoxville to Spartanburg in March is currently the most expensive (average of $328). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SB1?

Find hourly flight availability from Knoxville to Spartanburg. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 30, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Knoxville to Spartanburg as you normally would.

What is the cheapest day to fly from Knoxville to Spartanburg?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Spartanburg. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to Spartanburg flight should consider departing on Friday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Knoxville to Spartanburg?

Reviews of airlines servicing Spartanburg

Get insights into the airlines that provide service to Spartanburg. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spartanburg. Reviews last updated July 30, 2025.
Read through reviews of airlines operating flights from Knoxville to Spartanburg, such as Delta, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,896 reviews
Delta
8.0
Very good
7,980 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Food

7.3

Comfort

7.9

Entertainment

7.9

Boarding

8.2

Crew

8.5

Overall

8.0

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Spartanburg. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Spartanburg?

    If you book a flight to Spartanburg from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 2 flights from McGhee Tyson to Spartanburg per day from 2 different airlines.

  • What are the cheapest airlines to fly from Knoxville to Spartanburg one-way?

    The cheapest airlines for a one-way flight from Knoxville to Spartanburg are Delta ($119), American Airlines ($183), and United Airlines ($264).

  • What are the most reliable airlines from Knoxville to Spartanburg?

    Before booking your flight to Spartanburg from Knoxville, check out the most reliable airlines to get you to your destination on time: Envoy Air (100%), PSA Airlines (84%), American Airlines( 78%).

  • What are the cheapest flights from Knoxville to Spartanburg?

    The cheapest flight price from Knoxville to Spartanburg is $125. On average you can expect to pay $356. The most popular route, (Knoxville McGhee Tyson - Charlotte Douglas), can usually be booked for $232.

  • Can I find deals for flights from Knoxville to Spartanburg that include hotel bookings?

    Yes. In addition to deals on Knoxville to Spartanburg flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Spartanburg?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Spartanburg.

  • Can I find deals for business class flights from Knoxville to Spartanburg?

    Yes. Cheapflights offers flight deals from Knoxville to Spartanburg by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Spartanburg?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Spartanburg (average of $248). Flying from Knoxville to Spartanburg in March is currently the most expensive (average of $328). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Spartanburg

See prices for flight routes from nearby airports that may be better suited for you.
Memphis to Augusta flights
Nashville to Charleston flights
Nashville to Savannah flights
Nashville to Charlotte flights
Memphis to Charlotte flights
Memphis to Savannah flights
Chattanooga to Savannah flights
Nashville to Columbia flights
Memphis to Charleston flights
Nashville to Myrtle Beach flights
Nashville to Greenville flights
Knoxville to Myrtle Beach flights
Chattanooga to Charlotte flights
Chattanooga to Charleston flights
Memphis to Myrtle Beach flights
Knoxville to Charleston flights
Memphis to Columbia flights
Knoxville to Savannah flights
Knoxville to Charlotte flights
Memphis to Greenville flights
Chattanooga to Myrtle Beach flights
Chattanooga to Columbia flights
Memphis to Hilton Head Island flights
Blountville to Myrtle Beach flights
Knoxville to Columbia flights
Nashville to Augusta flights
Knoxville to Hilton Head Island flights
Blountville to Charlotte flights
Nashville to Hilton Head Island flights
Memphis to Florence flights
Chattanooga to Hilton Head Island flights
Nashville to Florence flights

Top 2 airlines flying from Knoxville to Spartanburg

Discover the top 2 airlines that operate flights from Knoxville to Spartanburg. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 30, 2025.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$286Average$530FlexibilityNo cancel feeOn-time71%
DeltaCheapest$286Average$334FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.