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Spartanburg

$94+ Cheap flights from Knoxville (TYS) to Spartanburg, SC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/27. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CLT
May 1 — May 81
Fri 5/1
Fri 5/8
1 adult, Economy
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Cheap flight deals from Knoxville to Spartanburg

Cheapest flights from Knoxville to Spartanburg
Explore the most affordable flight options available from Knoxville to Spartanburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 1, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/143:48 pm
TYS
-
CLT
1 stop24h 47m
Multiple Airlines
Thu 4/166:35 pm
CLT
-
TYS
1 stop22h 55m
Multiple Airlines
Deal found 3/31$180
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/131:15 pm
TYS
-
CLT
1 stop27h 20m
Multiple Airlines
Thu 4/166:35 pm
CLT
-
TYS
1 stop22h 55m
Multiple Airlines
Deal found 3/30$191
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/171:15 pm
TYS
-
CLT
1 stop7h 22m
Multiple Airlines
Mon 4/2010:22 am
CLT
-
TYS
1 stop7h 08m
Multiple Airlines
Deal found 3/30$193
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/131:15 pm
TYS
-
CLT
1 stop27h 20m
Multiple Airlines
Fri 4/1712:05 pm
CLT
-
TYS
1 stop5h 25m
Multiple Airlines
Deal found 3/29$195
This Kiwi.com deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/171:15 pm
TYS
-
CLT
1 stop7h 22m
Multiple Airlines
Sun 4/199:32 pm
CLT
-
TYS
1 stop19h 58m
Multiple Airlines
Deal found 3/30$207
This Kiwi.com deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/241:15 pm
TYS
-
CLT
1 stop7h 22m
Multiple Airlines
Sun 4/267:19 pm
CLT
-
TYS
1 stop22h 11m
Multiple Airlines
Deal found 3/31$212
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:20 pm
TYS
-
CLT
1 stop13h 49m
Multiple Airlines
Fri 5/19:32 pm
CLT
-
TYS
1 stop20h 31m
Multiple Airlines
Deal found 3/27$216
This Kiwi.com deal was found by Cheapflights users on 3/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1211:27 am
TYS
-
CLT
2 stops22h 10m
Multiple Airlines
Thu 4/166:35 pm
CLT
-
TYS
1 stop22h 55m
Multiple Airlines
Deal found 3/27$218
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/59:46 pm
TYS
-
CLT
1 stop11h 32m
Multiple Airlines
Mon 4/69:00 pm
CLT
-
TYS
1 stop17h 06m
Multiple Airlines
Deal found 3/29$232
This Kiwi.com deal was found by Cheapflights users on 3/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/154:25 pm
TYS
-
CLT
1 stop16h 45m
Multiple Airlines
Thu 4/169:32 pm
CLT
-
TYS
1 stop19h 58m
Multiple Airlines
Deal found 3/29$234
This Kiwi.com deal was found by Cheapflights users on 3/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/32:06 pm
TYS
-
CLT
1 stop10h 30m
Multiple Airlines
Mon 4/69:00 pm
CLT
-
TYS
1 stop17h 06m
Multiple Airlines
Deal found 3/28$235

Find flight deals from Knoxville to Spartanburg

Keep the following information in mind while searching for Knoxville to Spartanburg flight deals. Data was last updated April 1, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$180
(Kiwi.com)

One-way from

$94
(Kiwi.com)

Popular in

June

Cheapest in

April

Average price

$367
Provider with most accurate pricing for Knoxville McGhee Tyson-Charlotte Douglas flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Charlotte Douglas flights.
Search Deals
From Knoxville McGhee Tyson to Spartanburg
Search Deals
One-way flight from Knoxville McGhee Tyson to Spartanburg
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($39 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Spartanburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2026.
Use the filters below to find and compare flights from Knoxville to Spartanburg that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Fri 4/24

6:20 pm-8:09 am

1 stop13h 49m

Charlotte Douglas

Fri 5/1

9:32 pm-6:03 pm

1 stop20h 31m

$216

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Wed 4/15

4:25 pm-8:05 am

2 stops15h 40m

Charlotte Douglas

Thu 4/16

9:32 pm-5:30 pm

1 stop19h 58m

$278

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Sun 4/12

5:10 pm-8:17 pm

1 stop27h 07m

Charlotte Douglas

Thu 4/16

6:35 pm-5:30 pm

1 stop22h 55m

$332

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Tue 7/21

6:55 pm-10:05 pm

1 stop3h 10m

Charlotte Douglas

Wed 7/22

6:50 am-12:05 pm

1 stop5h 15m

$337

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Sun 4/26

6:40 am-4:10 pm

2 stops9h 30m

Charlotte Douglas

Sun 5/31

6:10 am-11:40 am

1 stop5h 30m

$342

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Fri 8/14

7:10 am-5:35 pm

2 stops10h 25m

Charlotte Douglas

Sun 8/16

7:10 am-12:25 pm

1 stop5h 15m

$348

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Fri 7/24

6:40 am-4:00 pm

2 stops9h 20m

Charlotte Douglas

Sun 7/26

6:30 am-12:05 pm

1 stop5h 35m

$368

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Wed 6/17

7:10 am-3:40 pm

2 stops8h 30m

Charlotte Douglas

Fri 6/19

11:35 am-9:10 pm

2 stops9h 35m

$472
Quickest round-trip

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Thu 4/16

2:06 pm-3:30 pm

Nonstop1h 24m

Charlotte Douglas

Sat 4/18

9:50 am-11:15 am

Nonstop1h 25m

$579

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

Thu 9/10

10:00 am-11:58 pm

1 stop13h 58m

Charlotte Douglas

Sat 9/26

7:47 pm-10:00 am

1 stop14h 13m

$626

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/1

Showing 1-10 of 22 resultsSorted by cheapest first
1
2
3

Best time to book a flight from Knoxville to Spartanburg

Have a flexible travel schedule? Discover the best time to fly to Spartanburg from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Spartanburg

What is the cheapest month to book a flight from Knoxville to Spartanburg?

Currently, November is the cheapest month in which you can book a flight from Knoxville to Spartanburg (average of $243). Flying from Knoxville to Spartanburg in September is currently the most expensive (average of $434). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SB1?

Find hourly flight availability from Knoxville to Spartanburg. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated April 1, 2026.

When flying from Knoxville to Spartanburg, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 43% versus a flight in the afternoon.

What is the cheapest day to fly from Knoxville to Spartanburg?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Spartanburg. Price data was last updated on March 28, 2026.

Travelers seeking maximum savings on their Knoxville to Spartanburg flight should consider departing on Monday evenings when fares are most often at their lowest. Monday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

How much does it cost to fly round-trip from Knoxville to Spartanburg?

Reviews of airlines servicing Spartanburg

Get insights into the airlines that provide service to Spartanburg. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spartanburg. Reviews last updated April 1, 2026.
Read through reviews of airlines operating flights from Knoxville to Spartanburg, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,545 reviews

Crew

7.9

Entertainment

6.9

Boarding

7.5

Overall

7.1

Food

6.4

Comfort

7.2

Reviews

1 / 20
4.0
Okay

Elizabeth,Mar 2026

ORD - MIA

Staff was rude and flight attendants 2 out of 3 looked like they had just been thru a hurricane.
American Airlines
7.1
Good
11,545 reviews
American Airlines
7.1
Good
11,545 reviews

Crew

7.9

Entertainment

6.9

Boarding

7.5

Overall

7.1

Food

6.4

Comfort

7.2

Reviews

1 / 20
4.0
Okay

Elizabeth,Mar 2026

ORD - MIA

Staff was rude and flight attendants 2 out of 3 looked like they had just been thru a hurricane.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Spartanburg. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Spartanburg?

    If you book a flight to Spartanburg from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 4 flights from McGhee Tyson to Spartanburg per day from 1 airline.

  • How popular is this Knoxville to Spartanburg flight route?

    The Knoxville McGhee Tyson to Spartanburg flight path was viewed by 17 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Knoxville to Spartanburg?

    Airlines like Southwest fly from Knoxville to Spartanburg in about 3h 10m. The time it takes to get you to your destination can typically vary by up to . Airlines will cover a distance of 176 mi.

  • What are the most reliable airlines from Knoxville to Spartanburg?

    Before booking your flight to Spartanburg from Knoxville, check out the most reliable airlines to get you to your destination on time: PSA Airlines (77%), American Airlines (75%), Piedmont Airlines( 74%).

  • What are the cheapest flights from Knoxville to Spartanburg?

    The cheapest flight price from Knoxville to Spartanburg is $149. On average you can expect to pay $435. The most popular route, (Knoxville McGhee Tyson - Charlotte Douglas), can usually be booked for $180.

  • Can I find deals for flights from Knoxville to Spartanburg that include hotel bookings?

    Yes. In addition to deals on Knoxville to Spartanburg flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Spartanburg?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Spartanburg.

  • Can I find deals for business class flights from Knoxville to Spartanburg?

    Yes. Cheapflights offers flight deals from Knoxville to Spartanburg by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Spartanburg?

    Currently, November is the cheapest month in which you can book a flight from Knoxville to Spartanburg (average of $243). Flying from Knoxville to Spartanburg in September is currently the most expensive (average of $434). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Top airline flying from Knoxville to Spartanburg

Discover the top airline that operate flights from Knoxville to Spartanburg. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 1, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$296Average$438FlexibilityNo cancel feeOn-time71%

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