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Spartanburg

$92+ Cheap flights from Knoxville (TYS) to Spartanburg, SC

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/23. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CLT
feb. 28 — mar. 71
sáb. 2/28
sáb. 3/7
1 adult, Economy
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Cheap flight deals from Knoxville to Spartanburg

Cheapest flights from Knoxville to Spartanburg
Explore the most affordable flight options available from Knoxville to Spartanburg. Find the lowest fares from popular airlines and budget airlines, with prices last updated on enero 29, 2026.

This Kiwi.com deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 2/245:14 pm
TYS
-
CLT
1 stop20h 37m
Multiple Airlines
mar. 3/32:46 pm
CLT
-
TYS
1 stop27h 40m
Multiple Airlines
Deal found 1/26$199
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 2/289:08 pm
TYS
-
CLT
1 stop11h 18m
Multiple Airlines
mar. 3/32:46 pm
CLT
-
TYS
1 stop27h 40m
Multiple Airlines
Deal found 1/28$213
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 2/139:36 pm
TYS
-
CLT
1 stop10h 50m
Multiple Airlines
vie. 2/207:13 pm
CLT
-
TYS
1 stop17h 51m
Multiple Airlines
Deal found 1/27$243
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 2/183:52 pm
TYS
-
CLT
1 stop8h 04m
Multiple Airlines
dom. 2/223:07 pm
CLT
-
TYS
1 stop27h 25m
Multiple Airlines
Deal found 1/27$249
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 2/612:55 pm
TYS
-
CLT
1 stop21h 00m
Multiple Airlines
dom. 2/89:59 pm
CLT
-
TYS
1 stop19h 29m
Multiple Airlines
Deal found 1/27$267
This Kiwi.com deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 2/127:00 am
TYS
-
CLT
1 stop16h 56m
Multiple Airlines
lun. 2/1610:42 pm
CLT
-
TYS
2 stops35h 26m
Multiple Airlines
Deal found 1/27$272

Find flight deals from Knoxville to Spartanburg

Keep the following information in mind while searching for Knoxville to Spartanburg flight deals. Data was last updated enero 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$199
(Kiwi.com)

One-way from

$92
(Kiwi.com)

Popular in

June

Cheapest in

April

Average price

$544
Provider with most accurate pricing for Knoxville McGhee Tyson-Charlotte Douglas flight deals.
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Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-Charlotte Douglas flights.
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From Knoxville McGhee Tyson to Spartanburg
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One-way flight from Knoxville McGhee Tyson to Spartanburg
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Highest demand for flights based on searches. 7% potential increase in price ($49 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($21 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Spartanburg that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 29, 2026.
Use the filters below to find and compare flights from Knoxville to Spartanburg that are best for you.

Fly from

Knoxville

Fly to

Spartanburg

Route

Depart

Return

Price

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

mar. 2/24

5:14 pm-1:51 pm

1 stop20h 37m

Charlotte Douglas

mar. 3/3

2:46 pm-6:26 pm

1 stop27h 40m

$199

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

sáb. 2/28

9:08 pm-8:26 am

1 stop11h 18m

Charlotte Douglas

mar. 3/3

2:46 pm-6:26 pm

1 stop27h 40m

$213

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

vie. 2/13

9:36 pm-8:26 am

1 stop10h 50m

Charlotte Douglas

vie. 2/20

7:13 pm-1:04 pm

1 stop17h 51m

$243

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

mié. 2/18

3:52 pm-11:56 pm

1 stop8h 04m

Charlotte Douglas

dom. 2/22

3:07 pm-6:32 pm

1 stop27h 25m

$249

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

mié. 4/15

7:05 am-12:55 pm

1 stop5h 50m

Charlotte Douglas

sáb. 4/18

10:55 am-6:30 pm

1 stop7h 35m

$267

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

jue. 2/12

7:00 am-11:56 pm

1 stop16h 56m

Charlotte Douglas

lun. 2/16

10:42 pm-10:08 am

2 stops35h 26m

$272

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

mar. 2/24

5:14 pm-10:17 am

1 stop17h 03m

$108

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

mié. 2/25

3:50 pm-7:58 am

2 stops16h 08m

$124

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

sáb. 2/28

9:08 pm-8:26 am

1 stop11h 18m

$129

KnoxvilleCharlotte

TYS - CLT

TYSCLT

Knoxville McGhee Tyson

vie. 2/27

9:36 pm-8:26 am

1 stop10h 50m

$129

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/26

Showing 1-10 of 18 results
1
2

Best time to book a flight from Knoxville to Spartanburg

Have a flexible travel schedule? Discover the best time to fly to Spartanburg from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Spartanburg

What is the cheapest month to book a flight from Knoxville to Spartanburg?

Currently, November is the cheapest month in which you can book a flight from Knoxville to Spartanburg (average of $243). Flying from Knoxville to Spartanburg in September is currently the most expensive (average of $434). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to SB1?

Find hourly flight availability from Knoxville to Spartanburg. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated enero 29, 2026.

When flying from Knoxville to Spartanburg, the time of day you fly usually plays a role in the price. Save by searching for a flight at noon, which can drop the price by up to 41% versus a flight in the afternoon.

What is the cheapest day to fly from Knoxville to Spartanburg?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Spartanburg. Price data was last updated on January 24, 2026.

Travelers seeking maximum savings on their Knoxville to Spartanburg flight should consider departing on Monday evenings when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing Spartanburg

Get insights into the airlines that provide service to Spartanburg. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spartanburg. Reviews last updated enero 29, 2026.
Read through reviews of airlines operating flights from Knoxville to Spartanburg, such as American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,206 reviews

Overall

7.2

Entertainment

6.9

Food

6.4

Crew

8.0

Boarding

7.5

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,206 reviews
American Airlines
7.2
Good
11,206 reviews

Overall

7.2

Entertainment

6.9

Food

6.4

Crew

8.0

Boarding

7.5

Comfort

7.2

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Spartanburg. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Spartanburg?

    If you book a flight to Spartanburg from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 3 flights from McGhee Tyson to Spartanburg per day from 2 different airlines.

  • How popular is this Knoxville to Spartanburg flight route?

    The Knoxville McGhee Tyson to Spartanburg flight path was viewed by 6 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the most reliable airlines from Knoxville to Spartanburg?

    Before booking your flight to Spartanburg from Knoxville, check out the most reliable airlines to get you to your destination on time: Piedmont Airlines (87%), American Airlines (84%), PSA Airlines( 79%).

  • What are the cheapest flights from Knoxville to Spartanburg?

    The cheapest flight price from Knoxville to Spartanburg is $149. On average you can expect to pay $410. The most popular route, (Knoxville McGhee Tyson - Charlotte Douglas), can usually be booked for $213.

  • Can I find deals for flights from Knoxville to Spartanburg that include hotel bookings?

    Yes. In addition to deals on Knoxville to Spartanburg flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Spartanburg?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Spartanburg.

  • Can I find deals for business class flights from Knoxville to Spartanburg?

    Yes. Cheapflights offers flight deals from Knoxville to Spartanburg by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Spartanburg?

    Currently, November is the cheapest month in which you can book a flight from Knoxville to Spartanburg (average of $243). Flying from Knoxville to Spartanburg in September is currently the most expensive (average of $434). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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Top 2 airlines flying from Knoxville to Spartanburg

Discover the top 2 airlines that operate flights from Knoxville to Spartanburg. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated enero 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$286Average$334FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$296Average$445FlexibilityNo cancel feeOn-time71%

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