South Carolina

$117+ Cheap flights from Wisconsin to South Carolina

MKE — CHS
Nov 29 — Dec 61
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1. Tell us where you want to go

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Cheap flight deals from Wisconsin to South Carolina

Cheapest flights from Wisconsin to South Carolina

Thu 12/105:00 am -
1 stop5h 06m
Tue 12/154:54 pm -
1 stop6h 43m
Deal found 10/29$233
Thu 12/106:00 am -
2 stops7h 28m
Tue 12/156:30 am -
1 stop5h 58m
Deal found 10/29$258
Fri 12/184:10 pm -
1 stop4h 35m
Mon 12/218:05 pm -
1 stop4h 35m
Deal found 10/28$279
Thu 12/316:20 am -
2 stops6h 50m
Thu 1/77:15 am -
2 stops9h 30m
Deal found 10/29$289
Tue 11/242:55 pm -
1 stop6h 05m
Tue 12/14:10 pm -
1 stop4h 50m
Deal found 10/27$295
Mon 11/165:44 pm -
1 stop15h 11m
Wed 11/182:42 pm -
1 stop19h 19m
Deal found 10/26$299
Thu 11/2611:20 am -
1 stop5h 25m
Wed 12/21:30 pm -
2 stops9h 45m
Deal found 10/25$300
Tue 11/1010:30 am -
1 stop21h 08m
Sat 11/147:00 am -
1 stop10h 18m
Deal found 10/26$303
Tue 12/16:43 pm -
1 stop4h 08m
Tue 12/811:53 am -
1 stop6h 45m
Deal found 10/28$303
Wed 12/25:00 am -
1 stop5h 29m
Sat 12/56:02 am -
1 stop6h 34m
Deal found 10/28$305
Thu 12/108:00 am -
2 stops9h 10m
Tue 12/152:50 pm -
2 stops8h 30m
Deal found 10/29$309
Wed 12/25:30 am -
1 stop7h 30m
Sat 12/56:45 am -
2 stops8h 06m
Deal found 10/28$310

Find flight deals from Wisconsin to South Carolina

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$233
(American Airlines)

One-way from

$117
(American Airlines)

Popular in

March

Cheapest in

January

Average price

$426
Provider with most accurate pricing for Milwaukee-Mitchell-Myrtle Beach Intl flight deals.
Provider most trusted by Cheapflights users for Milwaukee-Mitchell-Myrtle Beach Intl flights.
From Wisconsin to South Carolina
One-way flight from Wisconsin to South Carolina
Highest demand for flights based on searches. 10% potential increase in price ($49 potential increase over avg. RT price).
Cheapest flight prices on average. 2% potential price decrease ($8 potential savings vs. average RT price).
Average for round-trip flights in October 2026

Cheapflights Fare Finder

 
Use the filters below to find and compare flights from Wisconsin to South Carolina that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

MilwaukeeGreenville

MKE Milwaukee-Mitchell - GSP Greenville

MKEGSP

Milwaukee-Mitchell

Thu 12/17

4:50 pm-11:00 pm

2 stops5h 10m

Greenville

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$122

MilwaukeeMyrtle Beach

MKE Milwaukee-Mitchell - MYR Myrtle Beach Intl

MKEMYR

Milwaukee-Mitchell

Tue 12/1

3:12 pm-10:47 pm

1 stop6h 35m

Myrtle Beach Intl

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$141

MilwaukeeMyrtle Beach

MKE Milwaukee-Mitchell - MYR Myrtle Beach Intl

MKEMYR

Milwaukee-Mitchell

Sat 11/21

4:40 pm-9:55 pm

1 stop4h 15m

Myrtle Beach Intl

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$141

MilwaukeeCharleston

MKE Milwaukee-Mitchell - CHS Charleston

MKECHS

Milwaukee-Mitchell

Wed 11/25

3:40 pm-12:15 am

2 stops7h 35m

Charleston

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$153

AppletonCharleston

ATW Appleton Intl - CHS Charleston

ATWCHS

Appleton Intl

Fri 11/13

6:03 pm-7:14 pm

1 stop24h 11m

Charleston

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$164

AppletonCharleston

ATW Appleton Intl - CHS Charleston

ATWCHS

Appleton Intl

Mon 11/9

4:07 pm-8:38 am

1 stop15h 31m

Charleston

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$170

MilwaukeeMyrtle Beach

MKE Milwaukee-Mitchell - MYR Myrtle Beach Intl

MKEMYR

Milwaukee-Mitchell

Sat 1/9

6:24 am-1:05 pm

1 stop5h 41m

Myrtle Beach Intl

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$176

MilwaukeeGreenville

MKE Milwaukee-Mitchell - GSP Greenville

MKEGSP

Milwaukee-Mitchell

Fri 11/27

2:55 pm-9:33 pm

1 stop5h 38m

Greenville

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$180

MilwaukeeMyrtle Beach

MKE Milwaukee-Mitchell - MYR Myrtle Beach Intl

MKEMYR

Milwaukee-Mitchell

Tue 12/1

2:55 pm-10:03 pm

2 stops6h 08m

Myrtle Beach Intl

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$194

MilwaukeeColumbia

MKE Milwaukee-Mitchell - CAE Columbia Metropolitan

MKECAE

Milwaukee-Mitchell

Wed 11/25

6:25 pm-11:57 pm

1 stop4h 32m

Columbia Metropolitan

Wed 12/31

12:00 am-11:00 pm

Nonstop0h 00m

$206

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/28

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Wisconsin to South Carolina

Have a flexible travel schedule? Discover the best time to fly to South Carolina from Wisconsin with our price prediction graph.
Estimated round-trip price

Cheapflights Insights

Everything you need to know about your flight from Wisconsin to South Carolina

What is the cheapest month to book a flight from Wisconsin to South Carolina?

Currently, February is the cheapest month in which you can book a flight from Wisconsin to South Carolina (average of $348). Flying from Wisconsin to South Carolina in April is currently the most expensive (average of $426). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Wisconsin to South Carolina?

Airfare is below average for this route at the moment.
Wisconsin to South Carolina flights typically cost between $387 and $596 in November.
The cheapest round-trip price found within the last 5 days was $295 on American Airlines (Nov 24-Dec 1).

How far ahead should I book a flight from Wisconsin to South Carolina?

The best time to book flights from Wisconsin to South Carolina is 60 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

Reviews of airlines servicing South Carolina

Get a feel of what it's like to fly with Southwest,Delta, andUnited Airlines from Wisconsin to South Carolina by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Comfort

8.0

Entertainment

7.4

Food

7.0

Overall

7.9

Crew

8.6

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Comfort

8.0

Entertainment

7.4

Food

7.0

Overall

7.9

Crew

8.6

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Comfort

8.0

Entertainment

7.4

Food

7.0

Overall

7.9

Crew

8.6

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Comfort

8.0

Entertainment

7.4

Food

7.0

Overall

7.9

Crew

8.6

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Comfort

8.0

Entertainment

7.4

Food

7.0

Overall

7.9

Crew

8.6

Boarding

8.1

Reviews

1 / 20
8.0
Excellent

Patricia,Oct 2026

DAL - TPA

I love flying southwest, Both flights were packed full full - so not room for all carry one and bags had to be checked but still good flights.

Related info for your journey

  • How long is the flight from Wisconsin to South Carolina?

    There are many flights that can get you from Wisconsin to South Carolina in 4h 03m. Fly via Delta, United Airlines, or Southwest to get the fastest option. Wisconsin and South Carolina are separated by a distance of 634 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Wisconsin to South Carolina one-way?

    To fly one-way, consider booking your trip with American Airlines, which is currently one of the cheapest options available, starting at $126. Delta flights start at $131 while deals on Southwest start at $138 one-way.

  • Can I find deals for flights from Wisconsin to South Carolina that include hotel bookings?

    Yes. In addition to deals on Wisconsin to South Carolina flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Wisconsin to South Carolina?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Wisconsin to South Carolina.

  • Can I find deals for business class flights from Wisconsin to South Carolina?

    Yes. Cheapflights offers flight deals from Wisconsin to South Carolina by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Wisconsin to South Carolina?

    Currently, February is the cheapest month in which you can book a flight from Wisconsin to South Carolina (average of $348). Flying from Wisconsin to South Carolina in April is currently the most expensive (average of $426). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Alternative routes for Wisconsin to South Carolina

Top 4 airlines flying from Wisconsin to South Carolina

AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$203Average$443FlexibilityNo cancel feeOn-time71%
DeltaCheapest$216Average$386FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$248Average$370FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$290Average$439FlexibilityNo cancel feeOn-time63%

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