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South America

$109+ Cheap flights from San Diego (SAN) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/16. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — BOG
ago. 19 — ago. 261
mar. 8/19
mar. 8/26
1 adult, Economy
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Cheap flight deals from San Diego to South America

Keep the following information in mind while searching for San Diego to South America flight deals. Data was last updated agosto 14, 2025.

Round-trip from

$407
(Copa Airlines)

One-way from

$109
(Mytrip)

Popular in

December

Cheapest in

August

Average price

$566
From San Diego to South America
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One-way flight from San Diego to South America
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Highest demand for flights based on searches. 14% potential increase in price ($166 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($34 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from San Diego to South America

Cheapest flights from San Diego to South America
Explore the most affordable flight options available from San Diego to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 14, 2025.

This Copa Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
dom. 10/199:12 pmSAN - MDE
1 stop11h 43mCopa Airlines
lun. 10/279:17 amMDE - SAN
1 stop10h 40mCopa Airlines
Deal found 8/14$407
This FlightHub deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/297:47 pmSAN - CTG
2 stops14h 36mSpirit Airlines
sáb. 10/41:29 pmCTG - SAN
2 stops12h 05mSpirit Airlines
Deal found 8/13$410
This Copa Airlines deal was found by Cheapflights users on 8/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 9/299:08 pmSAN - BOG
1 stop14h 21mCopa Airlines
vie. 10/108:35 amBOG - SAN
1 stop11h 22mCopa Airlines
Deal found 8/12$411
This FlightHub deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/121:35 pmSAN - CTG
2 stops20h 48mSpirit Airlines
vie. 9/191:29 pmCTG - SAN
2 stops20h 00mSpirit Airlines
Deal found 8/13$414
This Copa Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/179:08 pmSAN - MDE
1 stop15h 07mCopa Airlines
dom. 9/219:15 amMDE - SAN
1 stop10h 35mCopa Airlines
Deal found 8/14$414
This Copa Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/249:08 pmSAN - CTG
1 stop9h 34mCopa Airlines
lun. 9/299:27 amCTG - SAN
1 stop10h 23mCopa Airlines
Deal found 8/14$418
This Mytrip deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/59:08 pmSAN - BOG
1 stop20h 59mCopa Airlines
jue. 9/1812:08 pmBOG - SAN
1 stop31h 42mCopa Airlines
Deal found 8/13$425
This Copa Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/58:10 pmSAN - MDE
1 stop15h 05mCopa Airlines
mié. 11/126:24 amMDE - SAN
1 stop13h 39mCopa Airlines
Deal found 8/14$426
This Copa Airlines deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/129:08 pmSAN - BOG
1 stop10h 21mCopa Airlines
vie. 9/198:35 amBOG - SAN
1 stop11h 15mCopa Airlines
Deal found 8/13$429
This Copa Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 8/159:03 pmSAN - MDE
1 stop9h 52mCopa Airlines
vie. 8/2210:46 amMDE - SAN
1 stop8h 58mCopa Airlines
Deal found 8/14$431
This oojo deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 11/58:10 pmSAN - BOG
1 stop11h 57mCopa Airlines
mar. 11/112:24 pmBOG - SAN
1 stop29h 39mCopa Airlines
Deal found 8/11$433
This FlightHub deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 11/1011:00 amSAN - LIM
2 stops16h 25mLATAM Airlines
mar. 11/188:25 amLIM - SAN
1 stop14h 42mLATAM Airlines
Deal found 8/14$438

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 14, 2025.
Use the filters below to find and compare flights from San Diego to South America that are best for you.

Fly from

San Diego

Fly to

South America

Route

Depart

Return

Price

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

dom. 10/19

9:12 pm-2:15 pm

1 stop15h 03m

Medellín Jose Maria Cordova Intl

lun. 10/27

10:46 am-5:57 pm

1 stop9h 11m

$407

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

mié. 11/12

8:10 pm-2:15 pm

1 stop15h 05m

Medellín Jose Maria Cordova Intl

mié. 11/19

6:24 am-5:03 pm

1 stop13h 39m

$407

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

mié. 9/3

9:08 pm-2:44 pm

1 stop15h 36m

Medellín Jose Maria Cordova Intl

mié. 9/10

10:46 am-5:50 pm

1 stop9h 04m

$407

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

vie. 10/24

9:12 pm-10:55 am

1 stop11h 43m

Medellín Jose Maria Cordova Intl

dom. 11/2

10:46 am-5:03 pm

1 stop9h 17m

$407

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

mié. 9/17

9:08 pm-2:15 pm

1 stop15h 07m

Medellín Jose Maria Cordova Intl

mié. 9/24

6:37 am-5:50 pm

1 stop13h 13m

$407

San DiegoCartagena

SAN - CTG

SANCTG

San Diego

lun. 9/29

7:47 pm-12:23 pm

2 stops14h 36m

Cartagena Rafael Nunez

sáb. 10/4

1:29 pm-11:34 pm

2 stops12h 05m

$410

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

mié. 10/29

9:07 pm-5:03 pm

1 stop17h 56m

Bogotá El Dorado

mar. 11/4

4:45 am-5:03 pm

1 stop15h 18m

$411

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

mié. 11/5

8:10 pm-5:26 pm

1 stop18h 16m

Bogotá El Dorado

mié. 11/12

5:50 am-5:03 pm

1 stop14h 13m

$411

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

lun. 9/22

9:08 pm-9:29 am

1 stop10h 21m

Bogotá El Dorado

lun. 10/6

9:45 am-5:57 pm

1 stop10h 12m

$411

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

lun. 9/29

9:08 pm-1:29 pm

1 stop14h 21m

Bogotá El Dorado

vie. 10/10

8:35 am-5:57 pm

1 stop11h 22m

$411

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/14

Showing 1-10 of 60 results
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Best time to book a flight from San Diego to South America

Have a flexible travel schedule? Discover the best time to fly to South America from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to South America

What is the cheapest month to book a flight from San Diego to South America?

Currently, May is the cheapest month in which you can book a flight from San Diego to South America (average of $359). Flying from San Diego to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAN to SA?

Find hourly flight availability from San Diego to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated agosto 14, 2025.

When flying from San Diego to South America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated agosto 14, 2025.
See what other customers who have flown with Delta, LATAM Airlines, and Copa Airlines from San Diego to South America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,980 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,840 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.5
Good
1,509 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,916 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,980 reviews

Crew

8.5

Comfort

7.9

Overall

8.0

Entertainment

7.9

Boarding

8.2

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from San Diego to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from San Diego to South America?

    Located just 2.6 mi from the city center, San Diego (SAN) is the airport most travelers will use when flying to South America from San Diego.

  • What are the cheapest airlines to fly from San Diego to South America one-way?

    The cheapest airlines for a one-way flight from San Diego to South America are Spirit Airlines ($119), Copa Airlines ($183), and United Airlines ($242).

  • What are the most popular routes from San Diego to South America?

    The most popular route from San Diego to South America is San Diego - Buenos Aires Ministro Pistarini. You may also consider San Diego - Sao Paulo Guarulhos Intl or San Diego - Lima J Chavez Intl.

  • Can I find deals for flights from San Diego to South America that include hotel bookings?

    Yes. In addition to deals on San Diego to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to South America.

  • Can I find deals for business class flights from San Diego to South America?

    Yes. Cheapflights offers flight deals from San Diego to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to South America?

    Currently, May is the cheapest month in which you can book a flight from San Diego to South America (average of $359). Flying from San Diego to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for San Diego to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from San Diego to South America

Discover the top 6 airlines that operate flights from San Diego to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$337Average$648FlexibilityNo cancel feeOn-time70%
Spirit AirlinesCheapest$406Average$549FlexibilityNo cancel feeOn-time65%
DeltaCheapest$449Average$1,015FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$453Average$922FlexibilityNo cancel feeOn-time69%
LATAM AirlinesCheapest$459Average$882FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$479Average$953FlexibilityNo cancel feeOn-time71%

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