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South America

$166+ Cheap flights from San Diego (SAN) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/9. Fares are subject to change and may not be available on all flights or dates of travel.
SAN — BOG
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from San Diego to South America

Keep the following information in mind while searching for San Diego to South America flight deals. Data was last updated September 17, 2025.

Round-trip from

$441
(Copa Airlines)

One-way from

$166
(Kiwi.com)

Popular in

December

Cheapest in

August

Average price

$759
From San Diego to South America
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One-way flight from San Diego to South America
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Highest demand for flights based on searches. 11% potential increase in price ($115 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($31 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from San Diego to South America

Cheapest flights from San Diego to South America
Explore the most affordable flight options available from San Diego to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Copa Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/159:12 pmSAN - MDE
1 stop9h 58mCopa Airlines
Wed 10/229:15 amMDE - SAN
1 stop10h 42mCopa Airlines
Deal found 9/16$441
This Copa Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/199:08 pmSAN - MDE
1 stop9h 09mCopa Airlines
Mon 9/225:31 amMDE - SAN
1 stop14h 19mCopa Airlines
Deal found 9/17$449
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/278:00 amSAN - MDE
1 stop11h 05mUnited Airlines
Sat 11/19:45 amMDE - SAN
1 stop14h 08mUnited Airlines
Deal found 9/15$453
This Copa Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/209:12 pmSAN - CTG
1 stop11h 48mCopa Airlines
Sun 10/266:21 amCTG - SAN
1 stop13h 36mCopa Airlines
Deal found 9/17$454
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/110:20 amSAN - MDE
1 stop8h 45mUnited Airlines
Fri 11/710:45 amMDE - SAN
2 stops25h 29mUnited Airlines
Deal found 9/14$457
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/58:39 pmSAN - MDE
2 stops22h 31mUnited Airlines
Tue 10/149:45 amMDE - SAN
2 stops24h 11mUnited Airlines
Deal found 9/15$461
This United Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/164:44 pmSAN - MDE
1 stop26h 26mUnited Airlines
Thu 10/239:45 amMDE - SAN
1 stop10h 25mUnited Airlines
Deal found 9/16$462
This United Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/207:00 amSAN - MDE
2 stops12h 10mUnited Airlines
Wed 9/249:45 amMDE - SAN
2 stops12h 01mUnited Airlines
Deal found 9/15$465
This Kiwi.com deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/139:12 pmSAN - MDE
1 stop9h 05mCopa Airlines
Mon 10/2010:46 amMDE - SAN
1 stop9h 11mCopa Airlines
Deal found 9/16$467
This Copa Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/229:12 pmSAN - GRU
1 stop23h 18mCopa Airlines
Mon 11/35:25 amGRU - SAN
1 stop16h 38mCopa Airlines
Deal found 9/15$468
This American Airlines deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/2410:31 pmSAN - MDE
2 stops12h 04mAmerican Airlines
Sun 11/23:10 pmMDE - SAN
1 stop23h 17mAmerican Airlines
Deal found 9/15$470
This Copa Airlines deal was found by Cheapflights users on 9/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/249:08 pmSAN - CTG
1 stop9h 34mCopa Airlines
Mon 9/299:27 amCTG - SAN
1 stop10h 23mCopa Airlines
Deal found 9/16$474

Cheapflights Fare Finder

 
Customize your flight search to find flights from San Diego to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from San Diego to South America that are best for you.

Fly from

San Diego

Fly to

South America

Route

Depart

Return

Price

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Wed 10/8

9:12 pm-9:10 am

1 stop9h 58m

Medellín Jose Maria Cordova Intl

Sun 10/12

5:04 am-5:57 pm

1 stop14h 53m

$441

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Wed 11/12

8:10 pm-9:51 am

1 stop10h 41m

Medellín Jose Maria Cordova Intl

Wed 11/19

5:00 am-5:03 pm

1 stop15h 03m

$441

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Fri 10/24

9:12 pm-8:17 am

1 stop9h 05m

Medellín Jose Maria Cordova Intl

Sun 11/2

10:46 am-5:03 pm

1 stop9h 17m

$441

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Wed 10/15

9:12 pm-2:15 pm

1 stop15h 03m

Medellín Jose Maria Cordova Intl

Wed 10/22

10:46 am-5:57 pm

1 stop9h 11m

$441

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Tue 11/11

7:50 pm-10:05 pm

2 stops23h 15m

Medellín Jose Maria Cordova Intl

Wed 11/19

10:45 am-6:24 pm

1 stop10h 39m

$453

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Sat 10/25

8:00 am-9:05 pm

1 stop11h 05m

Medellín Jose Maria Cordova Intl

Thu 10/30

9:45 am-6:24 pm

1 stop10h 39m

$453

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Mon 10/27

8:00 am-9:05 pm

1 stop11h 05m

Medellín Jose Maria Cordova Intl

Sat 11/1

9:45 am-9:53 pm

1 stop14h 08m

$453

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Mon 10/27

7:50 pm-9:05 pm

2 stops23h 15m

Medellín Jose Maria Cordova Intl

Thu 10/30

9:45 am-6:24 pm

1 stop10h 39m

$453

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

Mon 10/27

7:50 pm-9:05 pm

2 stops23h 15m

Medellín Jose Maria Cordova Intl

Fri 10/31

9:45 am-6:24 pm

1 stop10h 39m

$453

San DiegoCartagena

SAN - CTG

SANCTG

San Diego

Mon 10/20

9:12 pm-2:15 pm

1 stop15h 03m

Cartagena Rafael Nunez

Sun 10/26

6:21 am-5:57 pm

1 stop13h 36m

$454

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/17

Showing 1-10 of 60 results
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Best time to book a flight from San Diego to South America

Have a flexible travel schedule? Discover the best time to fly to South America from San Diego with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to South America

What is the cheapest month to book a flight from San Diego to South America?

Currently, May is the cheapest month in which you can book a flight from San Diego to South America (average of $359). Flying from San Diego to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SAN to SA?

Find hourly flight availability from San Diego to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 17, 2025.

When flying from San Diego to South America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated September 17, 2025.
See what other customers who have flown with Delta, Copa Airlines, and LATAM Airlines from San Diego to South America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,961 reviews

Overall

8.0

Boarding

8.2

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,961 reviews
Delta
8.0
Very good
7,961 reviews

Overall

8.0

Boarding

8.2

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Copa Airlines
7.6
Good
1,533 reviews
Delta
8.0
Very good
7,961 reviews

Overall

8.0

Boarding

8.2

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
LATAM Airlines
7.5
Good
1,849 reviews
Delta
8.0
Very good
7,961 reviews

Overall

8.0

Boarding

8.2

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
United Airlines
7.4
Good
8,926 reviews
Delta
8.0
Very good
7,961 reviews

Overall

8.0

Boarding

8.2

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,961 reviews

Overall

8.0

Boarding

8.2

Crew

8.5

Comfort

7.9

Food

7.3

Entertainment

7.9

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from San Diego to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from San Diego to South America?

    Located just 2.6 mi from the city center, San Diego (SAN) is the airport most travelers will use when flying to South America from San Diego.

  • How long is the flight from San Diego to South America?

    Airlines like Copa Airlines, United Airlines, and Delta fly from San Diego to South America in about 9h 58m. The time it takes to get you to your destination can typically vary by up to 9h 52m. Airlines will cover a distance of 3246 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from San Diego to South America one-way?

    The cheapest airlines for a one-way flight from San Diego to South America are Copa Airlines ($200), United Airlines ($203), and JetBlue ($224).

  • What are the most popular routes from San Diego to South America?

    The most popular route from San Diego to South America is San Diego - Medellín Jose Maria Cordova Intl. You may also consider San Diego - Sao Paulo Guarulhos Intl or San Diego - Buenos Aires Ministro Pistarini.

  • Can I find deals for flights from San Diego to South America that include hotel bookings?

    Yes. In addition to deals on San Diego to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from San Diego to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to South America.

  • Can I find deals for business class flights from San Diego to South America?

    Yes. Cheapflights offers flight deals from San Diego to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from San Diego to South America?

    Currently, May is the cheapest month in which you can book a flight from San Diego to South America (average of $359). Flying from San Diego to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for San Diego to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 6 airlines flying from San Diego to South America

Discover the top 6 airlines that operate flights from San Diego to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
Spirit AirlinesCheapest$314Average$610FlexibilityNo cancel feeOn-time65%
Copa AirlinesCheapest$337Average$622FlexibilityNo cancel feeOn-time70%
DeltaCheapest$430Average$1,026FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$449Average$919FlexibilityNo cancel feeOn-time69%
LATAM AirlinesCheapest$452Average$860FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$479Average$951FlexibilityNo cancel feeOn-time71%

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