How long is the flight from San Diego to South America?

Airlines like American Airlines, Delta, and LATAM Airlines fly from San Diego to South America in about 19h 08m. The time it takes to get you to your destination can typically vary by up to 17m. Airlines will cover a distance of 6057 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines to fly from San Diego to South America one-way?

The cheapest airlines for a one-way flight from San Diego to South America are Copa Airlines ($169), United Airlines ($202), and American Airlines ($232).

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

What are the most popular routes from San Diego to South America?

The most popular route from San Diego to South America is San Diego - Sao Paulo Guarulhos Intl. You may also consider San Diego - Medellín Jose Maria Cordova Intl or San Diego - Lima J Chavez Intl.

What are the most popular airlines that fly from San Diego to South America?

The most popular airlines flying from San Diego to South America are United Airlines, Copa Airlines and American Airlines. Something to consider prior to booking your flight.

What is the cheapest time of day to fly from SAN to SA?

When flying from San Diego to South America, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What airport do you fly from for flights from San Diego to South America?

Located just 2.6 mi from the city center, San Diego (SAN) is the airport most travelers will use when flying to South America from San Diego.

Can I find deals for flights from San Diego to South America that include hotel bookings?

Yes. In addition to deals on San Diego to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from San Diego to South America?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to South America.

Can I find deals for business class flights from San Diego to South America?

Yes. Cheapflights offers flight deals from San Diego to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$163+ Flights from San Diego to South America

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from San Diego to South America with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from San Diego to South America

Cheapest flights from San Diego to South America
Explore the most affordable flight options available from San Diego to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 28, 2025.

mié. 12/319:35 amSAN - BOG

1 stop25h 50mMultiple Airlines

mar. 1/139:15 amBOG - SAN

1 stop28h 38mMultiple Airlines

Deal found 12/26

$370

lun. 12/298:00 amSAN - GRU

1 stop16h 40mLATAM Airlines

mié. 1/1410:50 pmGRU - SAN

2 stops40h 08mLATAM Airlines

Deal found 12/25

$640

mar. 12/306:15 amSAN - GRU

1 stop18h 25mLATAM Airlines

dom. 1/410:40 pmGRU - SAN

2 stops23h 59mLATAM Airlines

Deal found 12/27

$654

sáb. 12/278:45 pmSAN - LIM

2 stops24h 10mUnited Airlines

sáb. 2/281:50 amLIM - SAN

1 stop12h 24mUnited Airlines

Deal found 12/26

$727

vie. 12/2612:56 pmSAN - GRU

1 stop16h 24mUnited Airlines

sáb. 1/179:45 pmGRU - SAN

1 stop19h 03mUnited Airlines

Deal found 12/26

$765

vie. 12/268:12 pmSAN - LIM

1 stop16h 28mCopa Airlines

vie. 5/17:00 amLIM - SAN

1 stop13h 30mCopa Airlines

Deal found 12/26

$768

mar. 12/306:15 amSAN - BOG

2 stops13h 20mUnited Airlines

mar. 1/61:30 amBOG - SAN

1 stop18h 06mUnited Airlines

Deal found 12/26

$769

lun. 12/295:03 pmSAN - LIM

1 stop12h 47mMultiple Airlines

vie. 1/1611:33 pmLIM - SAN

2 stops23h 13mMultiple Airlines

Deal found 12/26

$777

lun. 12/299:45 pmSAN - LIM

2 stops20h 50mDelta

mié. 1/1412:05 pmLIM - SAN

1 stop13h 42mDelta

Deal found 12/26

$780

mié. 12/316:20 amSAN - LIM

2 stops23h 30mLATAM Airlines

mié. 1/1412:05 pmLIM - SAN

1 stop13h 42mLATAM Airlines

Deal found 12/26

$785

lun. 12/2910:58 pmSAN - LIM

1 stop20h 12mMultiple Airlines

mié. 12/3112:05 pmLIM - SAN

1 stop14h 08mMultiple Airlines

Deal found 12/25

$796

vie. 12/2610:30 pmSAN - LIM

2 stops30h 30mLATAM Airlines

vie. 5/18:55 amLIM - SAN

2 stops26h 49mLATAM Airlines

Deal found 12/26

$812

Best flights from San Diego to South America
Discover carefully curated flight deals from San Diego to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated diciembre 28, 2025.

mié. 2/43:30 pmSAN - BOG

1 stop18h 00mMultiple Airlines

dom. 2/87:05 amBOG - SAN

1 stop15h 44mMultiple Airlines

Deal found 12/26

$353

dom. 4/199:18 pmSAN - MDE

1 stop15h 27mCopa Airlines

dom. 4/266:25 amMDE - SAN

1 stop14h 05mCopa Airlines

Deal found 12/27

$521

vie. 4/103:45 pmSAN - LIM

1 stop13h 40mLATAM Airlines

lun. 4/2712:00 pmLIM - SAN

1 stop12h 46mLATAM Airlines

Deal found 12/26

$584

dom. 3/18:02 amSAN - GRU

1 stop19h 08mAmerican Airlines

sáb. 3/711:30 pmGRU - SAN

1 stop16h 38mAmerican Airlines

Deal found 12/27

$600

vie. 4/36:15 amSAN - GRU

1 stop19h 25mDelta

mar. 4/1410:50 pmGRU - SAN

1 stop23h 49mDelta

Deal found 12/26

$600

dom. 3/88:50 pmSAN - GRU

2 stops32h 40mUnited Airlines

mié. 3/1110:15 pmGRU - SAN

1 stop21h 24mUnited Airlines

Deal found 12/25

$605

dom. 1/189:00 pmSAN - BOG

1 stop20h 25mMultiple Airlines

mar. 1/275:00 pmBOG - SAN

1 stop24h 18mMultiple Airlines

Deal found 12/26

$353

mié. 3/41:00 pmSAN - VCP

2 stops25h 00mGOL

mar. 3/317:40 pmVCP - SAN

2 stops20h 28mGOL

Deal found 12/27

$754

sáb. 3/73:30 pmSAN - BOG

1 stop18h 00mMultiple Airlines

dom. 3/157:05 amBOG - SAN

1 stop14h 43mMultiple Airlines

Deal found 12/27

$353

lun. 3/166:05 pmSAN - GIG

2 stops37h 00mAir Canada

mié. 3/188:00 pmGIG - SAN

1 stop19h 53mAir Canada

Deal found 12/25

$801

sáb. 1/247:51 amSAN - BOG

1 stop19h 24mMultiple Airlines

sáb. 1/317:05 amBOG - SAN

1 stop15h 41mMultiple Airlines

Deal found 12/27

$375

dom. 1/189:00 pmSAN - BOG

1 stop20h 25mMultiple Airlines

vie. 1/237:05 amBOG - SAN

1 stop15h 45mMultiple Airlines

Deal found 12/28

$386

mié. 2/48:17 pmSAN - MDE

1 stop14h 58mCopa Airlines

dom. 2/86:25 amMDE - SAN

1 stop13h 48mCopa Airlines

Deal found 12/26

$521

mié. 3/48:18 pmSAN - MDE

1 stop11h 38mCopa Airlines

dom. 3/1510:46 amMDE - SAN

1 stop9h 28mCopa Airlines

Deal found 12/27

$521

sáb. 2/77:51 amSAN - BOG

1 stop19h 24mMultiple Airlines

dom. 2/228:00 amBOG - SAN

1 stop29h 30mMultiple Airlines

Deal found 12/28

$400

lun. 1/266:35 amSAN - GRU

1 stop18h 05mDelta

lun. 2/29:15 pmGRU - SAN

1 stop26h 36mDelta

Deal found 12/27

$600

vie. 4/36:15 amSAN - GRU

1 stop19h 25mLATAM Airlines

mar. 4/1410:50 pmGRU - SAN

2 stops24h 24mLATAM Airlines

Deal found 12/27

$604

sáb. 1/173:30 pmSAN - BOG

1 stop18h 00mMultiple Airlines

mar. 1/2011:15 pmBOG - SAN

1 stop23h 35mMultiple Airlines

Deal found 12/28

$406

lun. 1/266:35 amSAN - GRU

1 stop18h 05mDelta

lun. 2/99:15 pmGRU - SAN

1 stop20h 40mDelta

Deal found 12/27

$600

vie. 1/2312:11 pmSAN - SCL

1 stop15h 39mUnited Airlines

vie. 1/3010:45 pmSCL - SAN

2 stops23h 43mUnited Airlines

Deal found 12/27

$669

dom. 2/18:17 pmSAN - LIM

1 stop13h 08mCopa Airlines

sáb. 2/142:35 amLIM - SAN

1 stop17h 38mCopa Airlines

Deal found 12/27

$581

dom. 3/17:25 pmSAN - GRU

2 stops19h 35mDelta

sáb. 3/710:55 pmGRU - SAN

2 stops19h 59mDelta

Deal found 12/27

$604

mar. 1/1311:08 amSAN - SCL

2 stops16h 42mUnited Airlines

lun. 2/210:45 pmSCL - SAN

2 stops21h 07mUnited Airlines

Deal found 12/26

$669

sáb. 1/249:00 pmSAN - MDE

1 stop29h 25mMultiple Airlines

sáb. 1/3111:00 pmMDE - SAN

1 stop18h 18mMultiple Airlines

Deal found 12/27

$416

mar. 2/101:19 pmSAN - SCL

1 stop13h 56mAmerican Airlines

sáb. 2/2810:00 pmSCL - SAN

1 stop19h 16mAmerican Airlines

Deal found 12/25

$741

vie. 2/208:17 pmSAN - LIM

1 stop13h 08mCopa Airlines

sáb. 2/282:35 amLIM - SAN

1 stop17h 39mCopa Airlines

Deal found 12/27

$581

dom. 3/2210:03 pmSAN - GRU

1 stop18h 52mDelta

sáb. 3/2810:40 amGRU - SAN

1 stop27h 13mDelta

Deal found 12/27

$605

jue. 1/812:40 pmSAN - GIG

1 stop18h 25mAir Canada

dom. 2/19:00 pmGIG - SAN

2 stops44h 03mAir Canada

Deal found 12/26

$835

mié. 4/2210:16 amSAN - SCL

1 stop16h 19mLATAM Airlines

sáb. 5/211:25 pmSCL - SAN

1 stop18h 30mLATAM Airlines

Deal found 12/28

$770

mié. 1/288:16 pmSAN - LIM

1 stop13h 09mCopa Airlines

lun. 2/97:00 amLIM - SAN

1 stop13h 13mCopa Airlines

Deal found 12/25

$581

Last-minute flights from San Diego to South America
Discover last-minute flight deals from San Diego to South America. Data last updated diciembre 28, 2025 and is based on user searches.

mié. 12/319:35 amSAN - BOG

1 stop25h 50mMultiple Airlines

mar. 1/139:15 amBOG - SAN

1 stop28h 38mMultiple Airlines

Deal found 12/26

$370

mar. 1/610:58 pmSAN - BOG

1 stop15h 52mMultiple Airlines

lun. 2/1611:15 pmBOG - SAN

1 stop23h 45mMultiple Airlines

Deal found 12/26

$433

sáb. 1/173:30 pmSAN - BOG

1 stop18h 00mMultiple Airlines

mar. 1/209:15 amBOG - SAN

1 stop28h 38mMultiple Airlines

Deal found 12/26

$368

dom. 1/189:00 pmSAN - BOG

1 stop20h 25mMultiple Airlines

mar. 1/275:00 pmBOG - SAN

1 stop24h 18mMultiple Airlines

Deal found 12/26

$353

dom. 1/189:00 pmSAN - BOG

1 stop20h 25mMultiple Airlines

vie. 1/237:05 amBOG - SAN

1 stop15h 45mMultiple Airlines

Deal found 12/28

$386

mar. 1/209:11 amSAN - LIM

2 stops15h 19mMultiple Airlines

lun. 2/23:00 amLIM - SAN

2 stops16h 30mMultiple Airlines

Deal found 12/27

$433

mié. 1/2111:08 amSAN - LIM

2 stops13h 22mMultiple Airlines

mar. 1/273:00 amLIM - SAN

2 stops16h 30mMultiple Airlines

Deal found 12/26

$487

jue. 1/227:51 amSAN - BOG

1 stop19h 24mMultiple Airlines

lun. 1/267:05 amBOG - SAN

1 stop15h 41mMultiple Airlines

Deal found 12/26

$375

sáb. 1/249:00 pmSAN - MDE

1 stop29h 25mMultiple Airlines

sáb. 1/3111:00 pmMDE - SAN

1 stop18h 18mMultiple Airlines

Deal found 12/27

$416

mié. 1/289:59 pmSAN - LIM

2 stops24h 51mMultiple Airlines

dom. 2/81:50 amLIM - SAN

2 stops21h 33mMultiple Airlines

Deal found 12/25

$490

mié. 1/287:51 amSAN - MDE

1 stop18h 34mMultiple Airlines

lun. 2/1611:00 pmMDE - SAN

1 stop24h 00mMultiple Airlines

Deal found 12/26

$506

vie. 1/309:11 amSAN - LIM

2 stops15h 19mMultiple Airlines

sáb. 2/142:55 amLIM - SAN

2 stops19h 10mMultiple Airlines

Deal found 12/26

$492

One-way flights from San Diego to South America
Search for one-way flight options from San Diego to South America. Find affordable one-way fares based on user searches. Data last updated diciembre 28, 2025.

dom. 1/189:00 pmSAN - BOG

1 stop20h 25mMultiple Airlines

Deal found 12/25

$163

lun. 3/2310:02 pmSAN - BOG

1 stop17h 48mMultiple Airlines

Deal found 12/27

$182

mar. 1/277:00 amSAN - MDE

3 stops37h 35mMultiple Airlines

Deal found 12/25

$188

dom. 1/258:16 pmSAN - MDE

3 stops23h 59mMultiple Airlines

Deal found 12/25

$189

lun. 1/269:46 amSAN - MDE

2 stops32h 54mMultiple Airlines

Deal found 12/25

$200

mié. 1/149:10 amSAN - BOG

1 stop26h 15mMultiple Airlines

Deal found 12/27

$201

lun. 4/137:00 amSAN - MDE

1 stop25h 55mMultiple Airlines

Deal found 12/27

$203

jue. 1/293:30 pmSAN - MDE

1 stop17h 20mMultiple Airlines

Deal found 12/25

$212

mié. 1/287:51 amSAN - MDE

1 stop18h 34mMultiple Airlines

Deal found 12/25

$213

mar. 4/1410:25 amSAN - MDE

1 stop22h 30mMultiple Airlines

Deal found 12/27

$217

vie. 1/309:45 pmSAN - MDE

3 stops32h 15mMultiple Airlines

Deal found 12/25

$221

mié. 1/79:10 amSAN - BOG

1 stop26h 15mMultiple Airlines

Deal found 12/27

$223

Find flight deals from San Diego to South America

Most accurate provider	eDreams 3 stars
Most trusted provider	eDreams 3 stars
Round-trip from	$297 (eDestinos)
One-way from	$163 (Trip.com)
Popular in	December
Cheapest in	August
Average price	$1,139

Provider with most accurate pricing for San Diego-Sao Paulo (SAO) flight deals.

Search Deals

Provider most trusted by Cheapflights users for San Diego-Sao Paulo (SAO) flights.

Search Deals

From San Diego to South America

Search Deals

One-way flight from San Diego to South America

Search Deals

Highest demand for flights based on searches. 12% potential increase in price ($111 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 4% potential price decrease ($32 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in December 2025

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Diego to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

mié. 2/4

3:30 pm-12:30 pm

1 stop18h 00m

Bogotá El Dorado

dom. 2/8

7:05 am-7:49 pm

1 stop15h 44m

$353

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

dom. 1/18

9:00 pm-8:25 pm

1 stop20h 25m

Bogotá El Dorado

mar. 1/27

5:00 pm-2:18 pm

1 stop24h 18m

$353

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

sáb. 3/7

3:30 pm-12:30 pm

1 stop18h 00m

Bogotá El Dorado

dom. 3/15

7:05 am-7:48 pm

1 stop14h 43m

$353

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

sáb. 1/24

7:51 am-6:15 am

1 stop19h 24m

Bogotá El Dorado

sáb. 1/31

7:05 am-7:46 pm

1 stop15h 41m

$375

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

dom. 1/18

9:00 pm-8:25 pm

1 stop20h 25m

Bogotá El Dorado

vie. 1/23

7:05 am-7:50 pm

1 stop15h 45m

$386

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

sáb. 2/7

7:51 am-6:15 am

1 stop19h 24m

Bogotá El Dorado

dom. 2/22

8:00 am-10:30 am

1 stop29h 30m

$400

San DiegoBogotá

SAN - BOG

SANBOG

San Diego

sáb. 1/17

3:30 pm-12:30 pm

1 stop18h 00m

Bogotá El Dorado

mar. 1/20

11:15 pm-7:50 pm

1 stop23h 35m

$406

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

sáb. 1/24

9:00 pm-5:25 am

1 stop29h 25m

Medellín Jose Maria Cordova Intl

sáb. 1/31

11:00 pm-2:18 pm

1 stop18h 18m

$416

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

dom. 4/19

9:18 pm-2:45 pm

1 stop15h 27m

Medellín Jose Maria Cordova Intl

dom. 4/26

6:25 am-6:30 pm

1 stop14h 05m

$521

San DiegoMedellín

SAN - MDE

SANMDE

San Diego

mié. 2/4

8:17 pm-2:15 pm

1 stop14h 58m

Medellín Jose Maria Cordova Intl

dom. 2/8

6:25 am-5:13 pm

1 stop13h 48m

$521

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/25

Showing 1-10 of 60 results

...

Best time to book a flight from San Diego to South America

Have a flexible travel schedule? Discover the best time to fly to South America from San Diego with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from San Diego to South America

What is the cheapest month to book a flight from San Diego to South America?

Currently, August is the cheapest month in which you can book a flight from San Diego to South America (average of $201). Flying from San Diego to South America in June is currently the most expensive (average of $481). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South America

See what other customers who have flown with Delta, Copa Airlines, and LATAM Airlines from San Diego to South America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

8,018 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Delta

7.9

Good

8,018 reviews

Delta

7.9

Good

8,018 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Copa Airlines

7.6

Good

1,561 reviews

Delta

7.9

Good

8,018 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

LATAM Airlines

7.5

Good

1,895 reviews

Delta

7.9

Good

8,018 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

United Airlines

7.4

Good

9,113 reviews

Delta

7.9

Good

8,018 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

American Airlines

7.2

Good

11,072 reviews

Delta

7.9

Good

8,018 reviews

Reviews

1 / 20

10.0

Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

What airport do you fly from for flights from San Diego to South America?
Located just 2.6 mi from the city center, San Diego (SAN) is the airport most travelers will use when flying to South America from San Diego.
How long is the flight from San Diego to South America?
Airlines like American Airlines, Delta, and LATAM Airlines fly from San Diego to South America in about 19h 08m. The time it takes to get you to your destination can typically vary by up to 17m. Airlines will cover a distance of 6057 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines to fly from San Diego to South America one-way?
The cheapest airlines for a one-way flight from San Diego to South America are Copa Airlines ($169), United Airlines ($202), and American Airlines ($232).
What are the most popular routes from San Diego to South America?
The most popular route from San Diego to South America is San Diego - Sao Paulo Guarulhos Intl. You may also consider San Diego - Medellín Jose Maria Cordova Intl or San Diego - Lima J Chavez Intl.
Can I find deals for flights from San Diego to South America that include hotel bookings?
Yes. In addition to deals on San Diego to South America flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from San Diego to South America?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from San Diego to South America.
Can I find deals for business class flights from San Diego to South America?
Yes. Cheapflights offers flight deals from San Diego to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from San Diego to South America?
Currently, August is the cheapest month in which you can book a flight from San Diego to South America (average of $201). Flying from San Diego to South America in June is currently the most expensive (average of $481). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 6 airlines flying from San Diego to South America

Airline	Cheapest	Average	Flexibility	On-time
Copa Airlines	Cheapest$342	Average$605	FlexibilityNo cancel fee	On-time70%
Delta	Cheapest$430	Average$1,003	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$442	Average$925	FlexibilityNo cancel fee	On-time69%
LATAM Airlines	Cheapest$452	Average$837	FlexibilityNo cancel fee	On-time81%
American Airlines	Cheapest$452	Average$909	FlexibilityNo cancel fee	On-time71%
GOL	Cheapest$645	Average$991	FlexibilityNo cancel fee	On-time74%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$163+ Cheap flights from San Diego (SAN) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/18. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from San Diego to South America with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from San Diego to South America

Cheapest flights from San Diego to South AmericaExplore the most affordable flight options available from San Diego to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 28, 2025.

Explore the most affordable flight options available from San Diego to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 28, 2025.

Find flight deals from San Diego to South America

Keep the following information in mind while searching for San Diego to South America flight deals. Data was last updated diciembre 28, 2025.

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Cheapflights Fare Finder

Use the filters below to find and compare flights from San Diego to South America that are best for you.

Best time to book a flight from San Diego to South America

Have a flexible travel schedule? Discover the best time to fly to South America from San Diego with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from San Diego to South America

What is the cheapest month to book a flight from San Diego to South America?

Reviews of airlines servicing South America

See what other customers who have flown with Delta, Copa Airlines, and LATAM Airlines from San Diego to South America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from San Diego to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

What airport do you fly from for flights from San Diego to South America?

How long is the flight from San Diego to South America?

What are the cheapest airlines to fly from San Diego to South America one-way?

What are the most popular routes from San Diego to South America?

Can I find deals for flights from San Diego to South America that include hotel bookings?

How can I find direct flights from San Diego to South America?

Can I find deals for business class flights from San Diego to South America?

What is the cheapest month to book a flight from San Diego to South America?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for San Diego to South America

See prices for flight routes from nearby airports that may be better suited for you.

Top 6 airlines flying from San Diego to South America

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from San Diego to South America
Explore the most affordable flight options available from San Diego to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 28, 2025.