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South America

$175+ Cheap flights from Greenville (GSP) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/19. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — BOG
Dec 2 — Dec 91
Tue 12/2
Tue 12/9
1 adult, Economy
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Find flight deals from Greenville to South America

Cheapest flights from Greenville to South America
Explore the most affordable flight options available from Greenville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 2, 2025.

This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/123:00 pmGSP - MDE
1 stop10h 09mMultiple Airlines
Thu 12/183:10 pmMDE - GSP
1 stop18h 41mMultiple Airlines
Deal found 11/1$299
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/123:00 pmGSP - MDE
1 stop10h 09mMultiple Airlines
Fri 12/192:25 amMDE - GSP
1 stop18h 26mMultiple Airlines
Deal found 11/1$323
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/83:00 pmGSP - MDE
1 stop10h 09mMultiple Airlines
Thu 12/183:10 pmMDE - GSP
1 stop18h 41mMultiple Airlines
Deal found 11/1$329
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/123:00 pmGSP - MDE
1 stop10h 09mMultiple Airlines
Wed 12/173:10 pmMDE - GSP
2 stops22h 16mMultiple Airlines
Deal found 11/1$348
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/83:00 pmGSP - MDE
1 stop10h 09mMultiple Airlines
Fri 12/192:25 amMDE - GSP
1 stop18h 26mMultiple Airlines
Deal found 11/1$353
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/88:03 pmGSP - MDE
1 stop14h 52mMultiple Airlines
Wed 12/172:54 pmMDE - GSP
1 stop19h 59mMultiple Airlines
Deal found 11/1$374
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/123:00 pmGSP - MDE
1 stop10h 09mMultiple Airlines
Sun 12/212:25 amMDE - GSP
1 stop17h 28mMultiple Airlines
Deal found 11/1$389
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/53:00 pmGSP - MDE
1 stop10h 09mMultiple Airlines
Sun 12/143:10 pmMDE - GSP
1 stop23h 00mMultiple Airlines
Deal found 11/1$397
This Kiwi.com deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/115:17 pmGSP - MDE
2 stops20h 57mMultiple Airlines
Thu 12/183:10 pmMDE - GSP
1 stop18h 41mMultiple Airlines
Deal found 11/1$412
This American Airlines deal was found by Cheapflights users on 11/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/165:10 amGSP - CTG
1 stop8h 20mAmerican Airlines
Tue 12/238:00 amCTG - GSP
1 stop11h 37mAmerican Airlines
Deal found 11/1$597
This Delta deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/55:35 amGSP - BOG
2 stops21h 40mDelta
Fri 12/195:00 amBOG - GSP
2 stops18h 42mDelta
Deal found 10/31$608
This American Airlines deal was found by Cheapflights users on 10/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/1310:16 amGSP - CTG
1 stop11h 14mAmerican Airlines
Sat 12/208:00 amCTG - GSP
1 stop16h 27mAmerican Airlines
Deal found 10/31$617

Cheap flight deals from Greenville to South America

Keep the following information in mind while searching for Greenville to South America flight deals. Data was last updated November 2, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$299
(Kiwi.com)

One-way from

$175
(Kiwi.com)
Provider with most accurate pricing for Greenville-Sao Paulo (SAO) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Sao Paulo (SAO) flights.
Search Deals
From Greenville to South America
Search Deals
One-way flight from Greenville to South America
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 2, 2025.
Use the filters below to find and compare flights from Greenville to South America that are best for you.

Fly from

Greenville

Fly to

South America

Route

Depart

Return

Price

GreenvilleCartagena

GSP - CTG

GSPCTG

Greenville

Sun 3/8

8:06 am-7:20 pm

2 stops12h 14m

Cartagena Rafael Nunez

Wed 3/18

3:50 pm-11:39 pm

1 stop6h 49m

$519

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Fri 3/27

6:45 am-2:33 pm

1 stop8h 48m

Bogotá El Dorado

Mon 3/30

10:55 am-11:36 pm

2 stops11h 41m

$525

GreenvillePereira

GSP - PEI

GSPPEI

Greenville

Sat 1/31

6:40 am-11:35 pm

2 stops40h 55m

Pereira Matecana

Sun 3/8

8:20 am-3:45 pm

2 stops54h 25m

$529

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Fri 1/23

6:55 pm-2:06 pm

1 stop19h 11m

Medellín Jose Maria Cordova Intl

Sun 2/8

7:00 am-6:25 pm

1 stop11h 25m

$536

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Wed 3/11

7:45 am-7:30 pm

1 stop12h 45m

Bogotá El Dorado

Fri 3/13

3:55 pm-9:27 am

1 stop16h 32m

$538

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Wed 3/11

6:50 am-10:35 pm

1 stop16h 45m

Bogotá El Dorado

Thu 3/12

1:30 am-9:52 pm

1 stop19h 22m

$538

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Wed 3/11

12:00 pm-8:20 pm

2 stops9h 20m

Bogotá El Dorado

Fri 3/13

3:55 pm-9:27 am

1 stop16h 32m

$543

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Fri 1/23

5:34 pm-10:05 pm

2 stops28h 31m

Medellín Jose Maria Cordova Intl

Sun 2/8

10:45 am-7:29 pm

2 stops32h 44m

$547

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Mon 12/8

5:28 pm-5:42 am

2 stops12h 14m

Medellín Jose Maria Cordova Intl

Mon 12/15

1:15 am-4:53 pm

2 stops15h 38m

$551

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Tue 12/9

9:19 am-5:42 am

2 stops20h 23m

Medellín Jose Maria Cordova Intl

Thu 12/18

10:45 am-10:56 am

2 stops24h 11m

$551

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/31

Showing 1-10 of 48 results
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Best time to book a flight from Greenville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to South America

What is the cheapest month to book a flight from Greenville to South America?

Currently, October is the cheapest month in which you can book a flight from Greenville to South America (average of $96). Flying from Greenville to South America in June is currently the most expensive (average of $426). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to SA?

Find hourly flight availability from Greenville to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 2, 2025.

One of the essential ways to save on airfare from Greenville to South America is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the morning could potentially save you up to 25% on airfare.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated November 2, 2025.
Read through reviews of airlines operating flights from Greenville to South America, such as Delta, LATAM Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
7,996 reviews

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
Delta
7.9
Good
7,996 reviews
Delta
7.9
Good
7,996 reviews

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
LATAM Airlines
7.5
Good
1,874 reviews
Delta
7.9
Good
7,996 reviews

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.
American Airlines
7.2
Good
11,032 reviews
Delta
7.9
Good
7,996 reviews

Crew

8.5

Overall

7.9

Comfort

7.9

Entertainment

7.9

Food

7.3

Boarding

8.2

Reviews

1 / 20
8.0
Excellent

Lane,Nov 2025

MEM - ATL

The crew was very friendly, but they only came around and offered the better Delta Comfort snacks one time. I thought they would come around more frequently on a 5 hour flight. They did do two beverage services though, which was nice.

Related info for your journey

Find useful and relevant information for your journey from Greenville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to South America?

    For a flight from Greenville to South America, you will be flying from Greenville. Greenville (GSP) is just 10.4 mi from the center of the city.

  • How long is the flight from Greenville to South America?

    American Airlines, Delta, and United Airlines can get you from Greenville to South America in just under 8h 48m. Your travel time can differ by up to 32h 07m. The distance from Greenville to South America is about 2148 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Greenville to South America one-way?

    To fly one-way, consider booking your trip with LATAM Airlines, which is currently one of the cheapest options available, starting at $307. American Airlines flights start at $307 while deals on Copa Airlines start at $329 one-way.

  • What are the most popular routes from Greenville to South America?

    The most popular route from Greenville to South America is Greenville - Medellín Jose Maria Cordova Intl. You may also consider Greenville - Lima J Chavez Intl or Greenville - Bogotá El Dorado.

  • Can I find deals for flights from Greenville to South America that include hotel bookings?

    Yes. In addition to deals on Greenville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to South America.

  • Can I find deals for business class flights from Greenville to South America?

    Yes. Cheapflights offers flight deals from Greenville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to South America?

    Currently, October is the cheapest month in which you can book a flight from Greenville to South America (average of $96). Flying from Greenville to South America in June is currently the most expensive (average of $426). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Greenville to South America

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Top 3 airlines flying from Greenville to South America

Discover the top 3 airlines that operate flights from Greenville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$502Average$876FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$502Average$874FlexibilityNo cancel feeOn-time71%
DeltaCheapest$532Average$923FlexibilityNo cancel feeOn-timeN/A

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