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South America

$132+ Cheap flights from Greenville (GSP) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/9. Fares are subject to change and may not be available on all flights or dates of travel.
GSP — BOG
Jan 17 — Jan 241
Sat 1/17
Sat 1/24
1 adult, Economy
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Cheap flight deals from Greenville to South America

Cheapest flights from Greenville to South America
Explore the most affordable flight options available from Greenville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 18, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2511:33 amGSP - MDE
2 stops34h 07mMultiple Airlines
Tue 12/302:25 amMDE - GSP
1 stop13h 30mMultiple Airlines
Deal found 12/16$509
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/2511:33 amGSP - MDE
2 stops34h 07mMultiple Airlines
Tue 12/301:00 pmMDE - GSP
1 stop26h 55mMultiple Airlines
Deal found 12/16$590
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/179:19 amGSP - BOG
2 stops19h 51mUnited Airlines
Fri 3/61:30 amBOG - GSP
2 stops45h 42mUnited Airlines
Deal found 12/16$615
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/228:07 pmGSP - BOG
1 stop16h 33mAmerican Airlines
Sat 3/78:00 amBOG - GSP
1 stop9h 47mAmerican Airlines
Deal found 12/16$673
This Kiwi.com deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/228:03 pmGSP - MDE
1 stop14h 52mMultiple Airlines
Wed 1/76:40 pmMDE - GSP
2 stops38h 18mMultiple Airlines
Deal found 12/16$723
This American Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:02 amGSP - MDE
1 stop15h 08mAmerican Airlines
Wed 1/147:00 amMDE - GSP
1 stop16h 57mAmerican Airlines
Deal found 12/17$738
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/235:36 pmGSP - MDE
2 stops28h 29mUnited Airlines
Thu 1/1510:45 amMDE - GSP
2 stops23h 31mUnited Airlines
Deal found 12/16$742
This United Airlines deal was found by Cheapflights users on 12/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:45 amGSP - MDE
1 stop15h 20mUnited Airlines
Thu 1/1510:45 amMDE - GSP
2 stops34h 02mUnited Airlines
Deal found 12/17$743
This FlightHub deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/227:59 pmGSP - BOG
1 stop18h 26mLATAM Airlines
Fri 1/91:35 amBOG - GSP
2 stops15h 18mLATAM Airlines
Deal found 12/15$749
This Kiwi.com deal was found by Cheapflights users on 12/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1910:41 amGSP - BOG
1 stop14h 31mMultiple Airlines
Sun 12/213:05 pmBOG - GSP
1 stop28h 48mMultiple Airlines
Deal found 12/15$763
This American Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/278:04 pmGSP - MDE
1 stop18h 02mAmerican Airlines
Tue 1/137:00 amMDE - GSP
1 stop11h 26mAmerican Airlines
Deal found 12/16$765
This United Airlines deal was found by Cheapflights users on 12/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/246:45 amGSP - MDE
1 stop15h 20mUnited Airlines
Wed 1/1410:45 amMDE - GSP
2 stops34h 02mUnited Airlines
Deal found 12/16$771

Find flight deals from Greenville to South America

Keep the following information in mind while searching for Greenville to South America flight deals. Data was last updated December 18, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

AranGrant
3 stars

Round-trip from

$387
(Kiwi.com)

One-way from

$132
(Kiwi.com)
Provider with most accurate pricing for Greenville-Sao Paulo (SAO) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Greenville-Sao Paulo (SAO) flights.
Search Deals
From Greenville to South America
Search Deals
One-way flight from Greenville to South America
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Greenville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
Use the filters below to find and compare flights from Greenville to South America that are best for you.

Fly from

Greenville

Fly to

South America

Route

Depart

Return

Price

GreenvilleCartagena

GSP - CTG

GSPCTG

Greenville

Sun 2/1

5:45 pm-1:10 pm

1 stop19h 25m

Cartagena Rafael Nunez

Sun 2/8

2:21 pm-8:58 am

1 stop18h 37m

$315

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Sun 1/25

6:45 pm-2:15 pm

1 stop19h 30m

Medellín Jose Maria Cordova Intl

Sun 2/1

3:15 pm-8:58 am

1 stop17h 43m

$387

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Fri 1/30

4:39 pm-12:50 pm

1 stop20h 11m

Bogotá El Dorado

Fri 2/6

1:45 pm-4:15 pm

2 stops50h 30m

$451

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Fri 2/13

6:00 am-11:30 pm

1 stop17h 30m

Bogotá El Dorado

Sun 2/22

8:00 am-11:56 pm

1 stop15h 56m

$453

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Fri 2/13

6:49 am-2:25 pm

1 stop7h 36m

Bogotá El Dorado

Sun 2/22

9:00 am-8:19 pm

1 stop11h 19m

$453

GreenvilleLima

GSP - LIM

GSPLIM

Greenville

Thu 1/22

6:45 pm-10:35 pm

1 stop27h 50m

Lima J Chavez Intl

Sat 1/31

11:33 pm-8:07 pm

2 stops44h 34m

$471

GreenvilleMedellín

GSP - MDE

GSPMDE

Greenville

Sat 1/31

10:00 am-11:35 pm

2 stops13h 35m

Medellín Jose Maria Cordova Intl

Fri 2/6

4:20 am-7:29 pm

2 stops15h 09m

$473

GreenvilleCartagena

GSP - CTG

GSPCTG

Greenville

Thu 2/19

7:29 pm-3:30 pm

1 stop20h 01m

Cartagena Rafael Nunez

Tue 2/24

4:30 pm-9:43 am

2 stops17h 13m

$501

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Thu 1/1

11:33 am-1:12 am

2 stops13h 39m

Bogotá El Dorado

Sat 1/17

3:06 pm-3:53 pm

1 stop24h 47m

$512

GreenvilleBogotá

GSP - BOG

GSPBOG

Greenville

Mon 2/2

7:46 pm-4:45 pm

2 stops20h 59m

Bogotá El Dorado

Thu 2/5

10:55 am-11:50 pm

2 stops12h 55m

$513

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/17

Showing 1-10 of 54 results
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Best time to book a flight from Greenville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Greenville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Greenville to South America

What is the cheapest month to book a flight from Greenville to South America?

Currently, October is the cheapest month in which you can book a flight from Greenville to South America (average of $96). Flying from Greenville to South America in June is currently the most expensive (average of $426). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GSP to SA?

Find hourly flight availability from Greenville to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 18, 2025.

One of the essential ways to save on airfare from Greenville to South America is to remain as flexible as possible. Flights that are at noon tend to be the most expensive. A flight in the morning could potentially save you up to 22% on airfare.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated December 18, 2025.
Read through reviews of airlines operating flights from Greenville to South America, such as Delta, LATAM Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,009 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,009 reviews
Delta
7.9
Good
8,009 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,893 reviews
Delta
7.9
Good
8,009 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,054 reviews
Delta
7.9
Good
8,009 reviews

Comfort

7.9

Boarding

8.1

Food

7.3

Overall

7.9

Entertainment

7.9

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Greenville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Greenville to South America?

    For a flight from Greenville to South America, you will be flying from Greenville. Greenville (GSP) is just 10.4 mi from the center of the city.

  • How long is the flight from Greenville to South America?

    American Airlines, Delta, and United Airlines can get you from Greenville to South America in just under 7h 36m. Your travel time can differ by up to 30h 54m. The distance from Greenville to South America is about 2148 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Greenville to South America?

    The most popular route from Greenville to South America is Greenville - Medellín Jose Maria Cordova Intl. You may also consider Greenville - Bogotá El Dorado or Greenville - Quito Mariscal Sucr.

  • Can I find deals for flights from Greenville to South America that include hotel bookings?

    Yes. In addition to deals on Greenville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Greenville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Greenville to South America.

  • Can I find deals for business class flights from Greenville to South America?

    Yes. Cheapflights offers flight deals from Greenville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Greenville to South America?

    Currently, October is the cheapest month in which you can book a flight from Greenville to South America (average of $96). Flying from Greenville to South America in June is currently the most expensive (average of $426). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Top 3 airlines flying from Greenville to South America

Discover the top 3 airlines that operate flights from Greenville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 18, 2025.
AirlineCheapestAverageFlexibilityOn-time
LATAM AirlinesCheapest$502Average$801FlexibilityNo cancel feeOn-time81%
American AirlinesCheapest$502Average$904FlexibilityNo cancel feeOn-time71%
DeltaCheapest$532Average$900FlexibilityNo cancel feeOn-timeN/A

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