How long is the flight from Columbus to South America?

For as low as $291, Spirit Airlines can have you in South America from Columbus in 9h 11m. There are 2382 mi between Columbus and South America. Both multi-stop and nonstop flights can be found to your destination and back.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

What are the most popular routes from Columbus to South America?

Most travelers choose Columbus - Medellín Jose Maria Cordova Intl, Columbus - Cartagena Rafael Nunez or Columbus - Buenos Aires Ministro Pistarini when deciding on the best route from Columbus to South America.

What are the most popular airlines that fly from Columbus to South America?

Consider American Airlines, Delta or LATAM Airlines when booking your flight. These represent the most popular airlines when flying from Columbus to South America.

Can I find deals for flights from Columbus to South America that include hotel bookings?

Yes. In addition to deals on Columbus to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Columbus to South America?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to South America.

Can I find deals for business class flights from Columbus to South America?

Yes. Cheapflights offers flight deals from Columbus to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$119+ Flights from Columbus to South America

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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

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We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

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Cheap flight deals from Columbus to South America

Round-trip from	$282 (Expedia)
One-way from	$119 (Travelocity)

From Columbus to South America

Search Deals

One-way flight from Columbus to South America

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Find flight deals from Columbus to South America

Cheapest flights from Columbus to South America
Explore the most affordable flight options available from Columbus to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

Thu 10/305:00 amCMH - BOG

1 stop9h 15mSpirit Airlines

Thu 11/61:57 pmBOG - CMH

1 stop18h 18mSpirit Airlines

Deal found 9/15

$282

Thu 10/95:00 amCMH - MDE

1 stop9h 11mSpirit Airlines

Fri 10/241:16 amMDE - CMH

1 stop9h 42mSpirit Airlines

Deal found 9/14

$291

Mon 9/295:15 amCMH - MDE

1 stop8h 59mSpirit Airlines

Wed 10/11:24 amMDE - CMH

1 stop9h 17mSpirit Airlines

Deal found 9/14

$309

Sat 11/84:08 pmCMH - CTG

2 stops21h 00mSpirit Airlines

Tue 11/112:16 pmCTG - CMH

1 stop6h 56mSpirit Airlines

Deal found 9/13

$313

Thu 10/235:00 amCMH - MDE

1 stop20h 21mSpirit Airlines

Sat 10/251:16 amMDE - CMH

1 stop9h 42mSpirit Airlines

Deal found 9/15

$335

Thu 10/95:00 amCMH - MDE

1 stop9h 11mSpirit Airlines

Thu 10/302:22 pmMDE - CMH

1 stop20h 36mSpirit Airlines

Deal found 9/14

$336

Wed 12/36:45 amCMH - MDE

1 stop11h 19mSpirit Airlines

Tue 12/96:59 pmMDE - CMH

1 stop14h 56mSpirit Airlines

Deal found 9/14

$348

Mon 10/65:00 amCMH - BOG

1 stop9h 15mSpirit Airlines

Mon 10/132:10 pmBOG - CMH

2 stops23h 19mSpirit Airlines

Deal found 9/14

$352

Thu 9/257:16 pmCMH - BOG

1 stop17h 44mSpirit Airlines

Sat 10/112:10 pmBOG - CMH

2 stops20h 13mSpirit Airlines

Deal found 9/14

$354

Sat 11/86:45 amCMH - CTG

1 stop6h 23mSpirit Airlines

Thu 11/132:16 pmCTG - CMH

1 stop6h 56mSpirit Airlines

Deal found 9/15

$360

Wed 9/245:15 amCMH - BOG

1 stop8h 55mSpirit Airlines

Sat 10/112:10 pmBOG - CMH

2 stops20h 13mSpirit Airlines

Deal found 9/14

$362

Wed 11/56:45 amCMH - CTG

1 stop6h 23mSpirit Airlines

Mon 11/102:16 pmCTG - CMH

1 stop6h 56mSpirit Airlines

Deal found 9/15

$363

Best flights from Columbus to South America
Discover carefully curated flight deals from Columbus to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2025.

Thu 10/95:00 amCMH - MDE

1 stop9h 11mSpirit Airlines

Fri 10/241:16 amMDE - CMH

1 stop9h 42mSpirit Airlines

Deal found 9/14

$291

Mon 10/612:28 pmCMH - BOG

1 stop7h 57mMultiple Airlines

Mon 10/139:20 amBOG - CMH

1 stop28h 09mMultiple Airlines

Deal found 9/14

$368

Thu 10/95:00 amCMH - MDE

1 stop9h 11mSpirit Airlines

Wed 10/291:16 amMDE - CMH

1 stop9h 42mSpirit Airlines

Deal found 9/14

$291

Sat 10/47:51 pmCMH - UIO

2 stops31h 14mAvianca

Sun 10/123:15 amUIO - CMH

2 stops29h 29mAvianca

Deal found 9/16

$625

Thu 11/276:30 amCMH - GYE

2 stops31h 04mUnited Airlines

Sun 12/712:20 pmGYE - CMH

2 stops34h 09mUnited Airlines

Deal found 9/14

$636

Mon 1/1212:11 pmCMH - UIO

1 stop11h 48mAmerican Airlines

Mon 1/267:45 amUIO - CMH

2 stops14h 36mAmerican Airlines

Deal found 9/14

$658

Thu 11/277:00 amCMH - UIO

1 stop11h 55mDelta

Sun 12/77:00 pmUIO - CMH

2 stops18h 23mDelta

Deal found 9/14

$668

Sat 11/84:08 pmCMH - CTG

2 stops21h 00mSpirit Airlines

Tue 11/112:16 pmCTG - CMH

1 stop6h 56mSpirit Airlines

Deal found 9/13

$313

Tue 11/49:30 amCMH - GRU

1 stop23h 05mAir Canada

Wed 11/129:30 pmGRU - CMH

1 stop25h 26mAir Canada

Deal found 9/14

$744

Thu 10/235:00 amCMH - MDE

1 stop14h 50mMultiple Airlines

Sun 10/261:00 pmMDE - CMH

1 stop21h 58mMultiple Airlines

Deal found 9/15

$373

Thu 10/305:00 amCMH - BOG

1 stop9h 15mSpirit Airlines

Thu 11/63:05 pmBOG - CMH

2 stops16h 36mSpirit Airlines

Deal found 9/15

$339

Wed 2/116:45 amCMH - BOG

1 stop11h 25mMultiple Airlines

Tue 2/249:15 amBOG - CMH

1 stop11h 57mMultiple Airlines

Deal found 9/14

$405

Sat 11/19:00 amCMH - EZE

2 stops21h 59mCopa Airlines

Fri 11/212:32 pmEZE - CMH

2 stops21h 17mCopa Airlines

Deal found 9/16

$972

Mon 10/65:00 amCMH - CTG

1 stop8h 25mMultiple Airlines

Wed 10/151:42 pmCTG - CMH

3 stops21h 16mMultiple Airlines

Deal found 9/15

$410

Fri 10/316:21 pmCMH - CTG

2 stops19h 04mSpirit Airlines

Fri 11/72:16 pmCTG - CMH

1 stop6h 56mSpirit Airlines

Deal found 9/15

$379

Tue 11/48:05 amCMH - EZE

2 stops20h 15mLATAM Airlines

Wed 11/124:05 amEZE - CMH

2 stops22h 13mLATAM Airlines

Deal found 9/15

$1,101

Wed 11/56:45 amCMH - CTG

1 stop6h 23mMultiple Airlines

Sun 11/99:27 amCTG - CMH

3 stops28h 17mMultiple Airlines

Deal found 9/15

$418

Wed 10/88:42 amCMH - MDE

2 stops16h 39mSpirit Airlines

Wed 10/291:16 amMDE - CMH

1 stop9h 42mSpirit Airlines

Deal found 9/16

$393

Fri 10/316:21 pmCMH - CTG

3 stops30h 52mMultiple Airlines

Fri 11/72:16 pmCTG - CMH

1 stop6h 56mMultiple Airlines

Deal found 9/15

$424

Thu 11/62:49 pmCMH - CTG

2 stops22h 19mSpirit Airlines

Tue 11/112:16 pmCTG - CMH

1 stop6h 56mSpirit Airlines

Deal found 9/16

$397

Mon 1/126:30 amCMH - UIO

1 stop18h 00mUnited Airlines

Sun 1/251:35 amUIO - CMH

1 stop9h 28mUnited Airlines

Deal found 9/14

$653

Sat 11/86:45 amCMH - CTG

1 stop6h 23mMultiple Airlines

Thu 11/1311:52 amCTG - CMH

3 stops24h 23mMultiple Airlines

Deal found 9/15

$431

Thu 3/126:45 amCMH - UIO

1 stop17h 45mUnited Airlines

Wed 3/1812:35 amUIO - CMH

2 stops13h 39mUnited Airlines

Deal found 9/14

$658

Wed 12/36:45 amCMH - CTG

1 stop6h 23mSpirit Airlines

Sun 12/72:16 pmCTG - CMH

1 stop6h 56mSpirit Airlines

Deal found 9/14

$409

Tue 11/49:30 amCMH - GRU

1 stop23h 05mAir Canada

Thu 11/139:30 pmGRU - CMH

1 stop25h 26mAir Canada

Deal found 9/14

$744

Sat 11/82:49 pmCMH - CTG

2 stops22h 19mSpirit Airlines

Thu 11/132:16 pmCTG - CMH

1 stop6h 56mSpirit Airlines

Deal found 9/16

$409

Thu 11/276:30 amCMH - UIO

1 stop18h 00mUnited Airlines

Sat 12/61:35 amUIO - CMH

1 stop9h 21mUnited Airlines

Deal found 9/14

$663

Mon 9/295:15 amCMH - GYE

2 stops19h 05mMultiple Airlines

Sat 10/254:15 amGYE - CMH

2 stops13h 23mMultiple Airlines

Deal found 9/14

$490

Fri 9/267:16 pmCMH - BOG

1 stop17h 44mSpirit Airlines

Tue 9/302:05 pmBOG - CMH

2 stops16h 24mSpirit Airlines

Deal found 9/13

$413

Fri 9/268:03 pmCMH - CTG

1 stop17h 20mSpirit Airlines

Tue 9/301:29 pmCTG - CMH

1 stop21h 12mSpirit Airlines

Deal found 9/14

$429

Last-minute flights from Columbus to South America
Discover last-minute flight deals from Columbus to South America. Data last updated September 16, 2025 and is based on user searches.

Wed 9/245:15 amCMH - BOG

1 stop8h 55mSpirit Airlines

Sat 10/112:10 pmBOG - CMH

2 stops20h 13mSpirit Airlines

Deal found 9/14

$362

Thu 9/257:16 pmCMH - BOG

1 stop17h 44mSpirit Airlines

Sat 10/112:10 pmBOG - CMH

2 stops20h 13mSpirit Airlines

Deal found 9/14

$354

Mon 9/295:15 amCMH - MDE

1 stop8h 59mSpirit Airlines

Wed 10/11:24 amMDE - CMH

1 stop9h 17mSpirit Airlines

Deal found 9/14

$309

Mon 10/65:00 amCMH - BOG

1 stop9h 15mSpirit Airlines

Mon 10/132:10 pmBOG - CMH

2 stops23h 19mSpirit Airlines

Deal found 9/14

$352

Mon 10/65:00 amCMH - CTG

1 stop8h 25mMultiple Airlines

Wed 10/159:48 pmCTG - CMH

2 stops13h 10mMultiple Airlines

Deal found 9/15

$373

Thu 10/95:00 amCMH - MDE

1 stop9h 11mSpirit Airlines

Fri 10/241:16 amMDE - CMH

1 stop9h 42mSpirit Airlines

Deal found 9/14

$291

Thu 10/95:00 amCMH - MDE

1 stop9h 11mSpirit Airlines

Thu 10/302:22 pmMDE - CMH

1 stop20h 36mSpirit Airlines

Deal found 9/14

$336

Tue 10/148:42 amCMH - MDE

2 stops40h 39mSpirit Airlines

Wed 10/221:59 pmMDE - CMH

2 stops20h 59mSpirit Airlines

Deal found 9/15

$364

Thu 10/235:00 amCMH - MDE

1 stop20h 21mSpirit Airlines

Sat 10/251:16 amMDE - CMH

1 stop9h 42mSpirit Airlines

Deal found 9/15

$335

Thu 10/235:00 amCMH - MDE

1 stop14h 50mMultiple Airlines

Sun 10/261:00 pmMDE - CMH

1 stop21h 58mMultiple Airlines

Deal found 9/15

$373

Wed 10/298:42 amCMH - MDE

2 stops16h 39mSpirit Airlines

Wed 11/52:54 pmMDE - CMH

1 stop17h 21mSpirit Airlines

Deal found 9/14

$372

Thu 10/305:00 amCMH - BOG

1 stop9h 15mSpirit Airlines

Thu 11/61:57 pmBOG - CMH

1 stop18h 18mSpirit Airlines

Deal found 9/15

$282

One-way flights from Columbus to South America
Search for one-way flight options from Columbus to South America. Find affordable one-way fares based on user searches. Data last updated September 16, 2025.

Sun 10/195:00 amCMH - CTG

1 stop8h 25mSpirit Airlines

Deal found 9/15

$119

Wed 10/15:15 amCMH - BOG

1 stop8h 55mSpirit Airlines

Deal found 9/14

$124

Tue 12/910:50 amCMH - MDE

1 stop7h 14mSpirit Airlines

Deal found 9/13

$133

Sun 10/192:36 pmCMH - CTG

2 stops22h 49mMultiple Airlines

Deal found 9/15

$146

Sat 12/64:55 pmCMH - MDE

1 stop21h 21mSpirit Airlines

Deal found 9/13

$148

Wed 10/15:15 amCMH - BOG

2 stops18h 20mMultiple Airlines

Deal found 9/14

$150

Thu 11/135:22 pmCMH - MDE

2 stops24h 42mSpirit Airlines

Deal found 9/16

$154

Sun 9/285:15 amCMH - MDE

1 stop8h 59mSpirit Airlines

Deal found 9/15

$169

Tue 9/235:15 amCMH - BOG

1 stop8h 55mSpirit Airlines

Deal found 9/15

$172

Mon 10/2012:28 pmCMH - CTG

3 stops24h 20mMultiple Airlines

Deal found 9/15

$175

Tue 12/910:50 amCMH - MDE

2 stops19h 28mMultiple Airlines

Deal found 9/13

$183

Sun 9/287:16 pmCMH - MDE

2 stops21h 59mMultiple Airlines

Deal found 9/15

$198

Cheapflights Fare Finder

Use the filters below to find and compare flights from Columbus to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbusMedellín

CMH - MDE

CMHMDE

Columbus

Thu 10/9

5:00 am-1:11 pm

1 stop9h 11m

Medellín Jose Maria Cordova Intl

Fri 10/24

1:16 am-11:58 am

1 stop9h 42m

$291

ColumbusMedellín

CMH - MDE

CMHMDE

Columbus

Thu 10/9

5:00 am-1:11 pm

1 stop9h 11m

Medellín Jose Maria Cordova Intl

Wed 10/29

1:16 am-11:58 am

1 stop9h 42m

$291

ColumbusCartagena

CMH - CTG

CMHCTG

Columbus

Sat 11/8

4:08 pm-1:08 pm

2 stops21h 00m

Cartagena Rafael Nunez

Tue 11/11

2:16 pm-9:12 pm

1 stop6h 56m

$313

ColumbusBogotá

CMH - BOG

CMHBOG

Columbus

Thu 10/30

5:00 am-1:15 pm

1 stop9h 15m

Bogotá El Dorado

Thu 11/6

3:05 pm-7:41 am

2 stops16h 36m

$339

ColumbusBogotá

CMH - BOG

CMHBOG

Columbus

Mon 10/6

12:28 pm-7:25 pm

1 stop7h 57m

Bogotá El Dorado

Mon 10/13

9:20 am-2:29 pm

1 stop28h 09m

$368

ColumbusMedellín

CMH - MDE

CMHMDE

Columbus

Thu 10/23

5:00 am-6:50 pm

1 stop14h 50m

Medellín Jose Maria Cordova Intl

Sun 10/26

1:00 pm-11:58 am

1 stop21h 58m

$373

ColumbusCartagena

CMH - CTG

CMHCTG

Columbus

Fri 10/31

6:21 pm-12:25 pm

2 stops19h 04m

Cartagena Rafael Nunez

Fri 11/7

2:16 pm-9:12 pm

1 stop6h 56m

$379

ColumbusMedellín

CMH - MDE

CMHMDE

Columbus

Wed 10/8

8:42 am-12:21 am

2 stops16h 39m

Medellín Jose Maria Cordova Intl

Wed 10/29

1:16 am-11:58 am

1 stop9h 42m

$393

ColumbusCartagena

CMH - CTG

CMHCTG

Columbus

Thu 11/6

2:49 pm-1:08 pm

2 stops22h 19m

Cartagena Rafael Nunez

Tue 11/11

2:16 pm-9:12 pm

1 stop6h 56m

$397

ColumbusBogotá

CMH - BOG

CMHBOG

Columbus

Wed 2/11

6:45 am-6:10 pm

1 stop11h 25m

Bogotá El Dorado

Tue 2/24

9:15 am-9:12 pm

1 stop11h 57m

$405

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/15

Showing 1-10 of 60 results

...

Best time to book a flight from Columbus to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Columbus with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbus to South America

What is the cheapest month to book a flight from Columbus to South America?

Currently, May is the cheapest month in which you can book a flight from Columbus to South America (average of $359). Flying from Columbus to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CMH to SA?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Columbus to South America as you normally would.

Reviews of airlines servicing South America

See what other customers who have flown with Delta, LATAM Airlines, and United Airlines from Columbus to South America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

8.0

Very good

7,957 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Delta

8.0

Very good

7,957 reviews

Delta

8.0

Very good

7,957 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

LATAM Airlines

7.5

Good

1,847 reviews

Delta

8.0

Very good

7,957 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

United Airlines

7.4

Good

8,924 reviews

Delta

8.0

Very good

7,957 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

American Airlines

7.2

Good

10,000 reviews

Delta

8.0

Very good

7,957 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Spirit Airlines

6.3

Okay

8,019 reviews

Delta

8.0

Very good

7,957 reviews

Reviews

1 / 20

10.0

Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

How long is the flight from Columbus to South America?
For as low as $291, Spirit Airlines can have you in South America from Columbus in 9h 11m. There are 2382 mi between Columbus and South America. Both multi-stop and nonstop flights can be found to your destination and back.
What are the most popular routes from Columbus to South America?
Most travelers choose Columbus - Medellín Jose Maria Cordova Intl, Columbus - Cartagena Rafael Nunez or Columbus - Buenos Aires Ministro Pistarini when deciding on the best route from Columbus to South America.
Can I find deals for flights from Columbus to South America that include hotel bookings?
Yes. In addition to deals on Columbus to South America flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Columbus to South America?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to South America.
Can I find deals for business class flights from Columbus to South America?
Yes. Cheapflights offers flight deals from Columbus to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Columbus to South America?
Currently, May is the cheapest month in which you can book a flight from Columbus to South America (average of $359). Flying from Columbus to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 6 airlines flying from Columbus to South America

Airline	Cheapest	Average	Flexibility	On-time
Spirit Airlines	Cheapest$261	Average$431	FlexibilityNo cancel fee	On-time65%
LATAM Airlines	Cheapest$370	Average$871	FlexibilityNo cancel fee	On-time81%
American Airlines	Cheapest$423	Average$774	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$534	Average$926	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$539	Average$925	FlexibilityNo cancel fee	On-timeN/A
Air Canada	Cheapest$744	Average$956	FlexibilityNo cancel fee	On-time67%

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$119+ Cheap flights from Columbus to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/19. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Columbus to South America with Cheapflights

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3. Compare prices and book

Cheap flight deals from Columbus to South America

Keep the following information in mind while searching for Columbus to South America flight deals. Data was last updated September 16, 2025.

Round-trip from

One-way from

Find flight deals from Columbus to South America

Cheapest flights from Columbus to South AmericaExplore the most affordable flight options available from Columbus to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

Explore the most affordable flight options available from Columbus to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Columbus to South America that are best for you.

Best time to book a flight from Columbus to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Columbus with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Columbus to South America

What is the cheapest month to book a flight from Columbus to South America?

What is the cheapest time of day to fly from CMH to SA?

Find hourly flight availability from Columbus to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 16, 2025.

Reviews of airlines servicing South America

See what other customers who have flown with Delta, LATAM Airlines, and United Airlines from Columbus to South America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Columbus to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Columbus to South America?

What are the most popular routes from Columbus to South America?

Can I find deals for flights from Columbus to South America that include hotel bookings?

How can I find direct flights from Columbus to South America?

Can I find deals for business class flights from Columbus to South America?

What is the cheapest month to book a flight from Columbus to South America?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Columbus to South America

See prices for flight routes from nearby airports that may be better suited for you.

Top 6 airlines flying from Columbus to South America

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Cheapest flights from Columbus to South America
Explore the most affordable flight options available from Columbus to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.