How long is the flight from Columbus to South America?

For as low as $301, Spirit Airlines can have you in South America from Columbus in 7h 17m. There are 2497 mi between Columbus and South America.

In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.

If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).

What are the most popular routes from Columbus to South America?

Most travelers choose Columbus - Medellín Jose Maria Cordova Intl, Columbus - Cartagena Rafael Nunez or Columbus - Buenos Aires Ministro Pistarini when deciding on the best route from Columbus to South America.

What are the most popular airlines that fly from Columbus to South America?

Consider Delta, American Airlines or Spirit Airlines when booking your flight. These represent the most popular airlines when flying from Columbus to South America.

Can I find deals for flights from Columbus to South America that include hotel bookings?

Yes. In addition to deals on Columbus to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Columbus to South America?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to South America.

Can I find deals for business class flights from Columbus to South America?

Yes. Cheapflights offers flight deals from Columbus to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$123+ Flights from Columbus to South America

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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

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Find flight deals from Columbus to South America

Cheapest flights from Columbus to South America
Explore the most affordable flight options available from Columbus to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

Mon 12/88:33 pmCMH - MDE

1 stop17h 41mSpirit Airlines

Thu 12/1111:50 amMDE - CMH

1 stop7h 48mSpirit Airlines

Deal found 11/25

$345

Mon 12/88:33 pmCMH - CTG

1 stop16h 37mSpirit Airlines

Thu 12/112:15 pmCTG - CMH

1 stop7h 59mSpirit Airlines

Deal found 11/25

$349

Fri 12/128:33 pmCMH - CTG

1 stop16h 37mSpirit Airlines

Mon 12/222:15 pmCTG - CMH

1 stop27h 18mSpirit Airlines

Deal found 11/25

$383

Mon 12/812:36 pmCMH - CTG

2 stops24h 34mMultiple Airlines

Thu 12/112:15 pmCTG - CMH

1 stop7h 59mMultiple Airlines

Deal found 11/25

$386

Tue 12/96:00 amCMH - MDE

2 stops19h 09mSpirit Airlines

Wed 12/102:05 amMDE - CMH

2 stops17h 33mSpirit Airlines

Deal found 11/23

$392

Sun 12/1411:14 amCMH - MDE

1 stop26h 43mSpirit Airlines

Wed 12/172:25 amMDE - CMH

1 stop15h 08mSpirit Airlines

Deal found 11/25

$399

Fri 12/128:33 pmCMH - CTG

1 stop16h 37mSpirit Airlines

Tue 12/162:15 pmCTG - CMH

2 stops29h 23mSpirit Airlines

Deal found 11/25

$406

Mon 12/1512:36 pmCMH - MDE

2 stops12h 33mMultiple Airlines

Wed 12/172:25 amMDE - CMH

1 stop15h 08mMultiple Airlines

Deal found 11/25

$407

Thu 12/46:45 pmCMH - BOG

1 stop18h 07mMultiple Airlines

Mon 12/153:05 pmBOG - CMH

2 stops19h 14mMultiple Airlines

Deal found 11/26

$441

Fri 12/128:33 pmCMH - CTG

1 stop16h 37mMultiple Airlines

Mon 12/229:51 pmCTG - CMH

3 stops26h 06mMultiple Airlines

Deal found 11/25

$448

Thu 12/1111:14 amCMH - CTG

2 stops25h 56mSpirit Airlines

Tue 12/162:15 pmCTG - CMH

2 stops29h 23mSpirit Airlines

Deal found 11/24

$464

Mon 12/88:33 pmCMH - BOG

2 stops26h 52mMultiple Airlines

Thu 12/113:05 pmBOG - CMH

2 stops19h 14mMultiple Airlines

Deal found 11/25

$467

Best flights from Columbus to South America
Discover carefully curated flight deals from Columbus to South America that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated November 26, 2025.

Mon 1/265:33 amCMH - BOG

1 stop7h 17mSpirit Airlines

Wed 1/283:06 pmBOG - CMH

1 stop18h 34mSpirit Airlines

Deal found 11/24

$301

Mon 1/196:15 amCMH - MDE

1 stop8h 00mMultiple Airlines

Thu 1/224:53 amMDE - CMH

2 stops19h 05mMultiple Airlines

Deal found 11/24

$371

Mon 1/266:15 amCMH - CTG

1 stop7h 00mSpirit Airlines

Thu 1/292:21 pmCTG - CMH

1 stop7h 52mSpirit Airlines

Deal found 11/23

$310

Mon 2/165:00 amCMH - GYE

2 stops17h 40mAmerican Airlines

Sun 3/13:31 pmGYE - CMH

2 stops19h 26mAmerican Airlines

Deal found 11/24

$657

Mon 1/196:15 amCMH - MDE

1 stop8h 00mSpirit Airlines

Fri 1/232:50 pmMDE - CMH

1 stop9h 08mSpirit Airlines

Deal found 11/24

$317

Thu 2/194:15 pmCMH - MDE

1 stop21h 44mMultiple Airlines

Tue 2/242:54 pmMDE - CMH

1 stop8h 59mMultiple Airlines

Deal found 11/24

$379

Wed 3/111:01 pmCMH - SCL

1 stop17h 39mDelta

Mon 3/236:30 pmSCL - CMH

2 stops18h 34mDelta

Deal found 11/23

$764

Thu 1/1511:03 amCMH - SCL

2 stops17h 32mLATAM Airlines

Wed 1/218:15 amSCL - CMH

2 stops17h 49mLATAM Airlines

Deal found 11/23

$764

Thu 1/155:33 amCMH - BOG

1 stop7h 17mSpirit Airlines

Wed 1/211:45 pmBOG - CMH

1 stop10h 13mSpirit Airlines

Deal found 11/23

$319

Mon 12/812:36 pmCMH - CTG

2 stops24h 34mMultiple Airlines

Thu 12/112:15 pmCTG - CMH

1 stop7h 59mMultiple Airlines

Deal found 11/25

$386

Sun 2/225:40 amCMH - BOG

1 stop7h 07mSpirit Airlines

Tue 3/31:47 pmBOG - CMH

1 stop10h 06mSpirit Airlines

Deal found 11/23

$346

Thu 1/155:33 amCMH - BOG

1 stop7h 17mMultiple Airlines

Wed 1/213:06 pmBOG - CMH

2 stops27h 27mMultiple Airlines

Deal found 11/23

$395

Mon 1/266:15 amCMH - GYE

1 stop18h 06mSpirit Airlines

Tue 1/271:26 amGYE - CMH

2 stops22h 32mSpirit Airlines

Deal found 11/23

$349

Sat 1/316:15 amCMH - BOG

2 stops11h 55mMultiple Airlines

Sun 2/88:50 amBOG - CMH

2 stops24h 50mMultiple Airlines

Deal found 11/25

$401

Fri 5/14:40 pmCMH - GIG

1 stop14h 35mUnited Airlines

Fri 5/159:05 pmGIG - CMH

1 stop19h 45mUnited Airlines

Deal found 11/25

$1,120

Mon 12/88:33 pmCMH - MDE

1 stop17h 41mSpirit Airlines

Wed 12/102:05 amMDE - CMH

1 stop20h 09mSpirit Airlines

Deal found 11/25

$363

Sun 1/256:15 amCMH - CTG

1 stop7h 00mMultiple Airlines

Sat 1/317:41 amCTG - CMH

3 stops25h 59mMultiple Airlines

Deal found 11/26

$407

Tue 1/205:33 amCMH - CTG

2 stops7h 42mSpirit Airlines

Thu 1/292:21 pmCTG - CMH

1 stop7h 52mSpirit Airlines

Deal found 11/25

$363

Wed 2/186:15 amCMH - MDE

1 stop7h 58mMultiple Airlines

Mon 2/239:23 pmMDE - CMH

2 stops36h 17mMultiple Airlines

Deal found 11/24

$410

Fri 2/204:15 pmCMH - BOG

1 stop20h 32mMultiple Airlines

Sat 3/71:47 pmBOG - CMH

1 stop17h 39mMultiple Airlines

Deal found 11/26

$412

Sat 1/315:33 amCMH - BOG

2 stops8h 34mSpirit Airlines

Sun 2/81:45 pmBOG - CMH

1 stop10h 13mSpirit Airlines

Deal found 11/25

$376

Wed 3/111:01 pmCMH - SCL

2 stops16h 24mLATAM Airlines

Mon 3/2310:10 pmSCL - CMH

1 stop12h 51mLATAM Airlines

Deal found 11/24

$764

Thu 3/121:01 pmCMH - SCL

1 stop17h 39mDelta

Mon 3/2310:30 pmSCL - CMH

1 stop19h 00mDelta

Deal found 11/23

$764

Mon 1/196:15 amCMH - MDE

2 stops17h 39mMultiple Airlines

Wed 1/214:48 amMDE - CMH

2 stops19h 10mMultiple Airlines

Deal found 11/24

$416

Tue 12/96:00 amCMH - MDE

2 stops19h 09mSpirit Airlines

Wed 12/102:05 amMDE - CMH

2 stops17h 33mSpirit Airlines

Deal found 11/23

$392

Wed 12/246:00 amCMH - SCL

2 stops21h 35mLATAM Airlines

Mon 1/196:40 amSCL - CMH

2 stops19h 24mLATAM Airlines

Deal found 11/24

$769

Mon 12/811:14 amCMH - MDE

3 stops27h 00mMultiple Airlines

Thu 12/116:43 amMDE - CMH

3 stops27h 36mMultiple Airlines

Deal found 11/25

$428

Sat 2/216:15 amCMH - CTG

1 stop6h 58mSpirit Airlines

Sun 3/12:21 pmCTG - CMH

1 stop7h 52mSpirit Airlines

Deal found 11/24

$394

Mon 1/2610:40 amCMH - BOG

2 stops26h 10mMultiple Airlines

Wed 1/288:10 amBOG - CMH

2 stops15h 48mMultiple Airlines

Deal found 11/24

$435

Fri 12/128:33 pmCMH - CTG

1 stop16h 37mSpirit Airlines

Tue 12/162:15 pmCTG - CMH

2 stops29h 23mSpirit Airlines

Deal found 11/25

$406

Last-minute flights from Columbus to South America
Discover last-minute flight deals from Columbus to South America. Data last updated November 26, 2025 and is based on user searches.

Thu 12/46:45 pmCMH - BOG

1 stop18h 07mMultiple Airlines

Mon 12/153:05 pmBOG - CMH

2 stops19h 14mMultiple Airlines

Deal found 11/26

$441

Mon 12/88:33 pmCMH - MDE

1 stop17h 41mSpirit Airlines

Thu 12/1111:50 amMDE - CMH

1 stop7h 48mSpirit Airlines

Deal found 11/25

$345

Mon 12/88:33 pmCMH - CTG

1 stop16h 37mSpirit Airlines

Thu 12/112:15 pmCTG - CMH

1 stop7h 59mSpirit Airlines

Deal found 11/25

$349

Mon 12/812:36 pmCMH - CTG

2 stops24h 34mMultiple Airlines

Thu 12/112:15 pmCTG - CMH

1 stop7h 59mMultiple Airlines

Deal found 11/25

$386

Mon 12/88:33 pmCMH - BOG

2 stops26h 52mMultiple Airlines

Thu 12/113:05 pmBOG - CMH

2 stops19h 14mMultiple Airlines

Deal found 11/25

$467

Tue 12/96:00 amCMH - MDE

2 stops19h 09mSpirit Airlines

Wed 12/102:05 amMDE - CMH

2 stops17h 33mSpirit Airlines

Deal found 11/23

$392

Thu 12/1111:14 amCMH - CTG

2 stops25h 56mSpirit Airlines

Tue 12/162:15 pmCTG - CMH

2 stops29h 23mSpirit Airlines

Deal found 11/24

$464

Fri 12/128:33 pmCMH - CTG

1 stop16h 37mSpirit Airlines

Mon 12/222:15 pmCTG - CMH

1 stop27h 18mSpirit Airlines

Deal found 11/25

$383

Fri 12/128:33 pmCMH - CTG

1 stop16h 37mSpirit Airlines

Tue 12/162:15 pmCTG - CMH

2 stops29h 23mSpirit Airlines

Deal found 11/25

$406

Fri 12/128:33 pmCMH - CTG

1 stop16h 37mMultiple Airlines

Mon 12/229:51 pmCTG - CMH

3 stops26h 06mMultiple Airlines

Deal found 11/25

$448

Sun 12/1411:14 amCMH - MDE

1 stop26h 43mSpirit Airlines

Wed 12/172:25 amMDE - CMH

1 stop15h 08mSpirit Airlines

Deal found 11/25

$399

Mon 12/1512:36 pmCMH - MDE

2 stops12h 33mMultiple Airlines

Wed 12/172:25 amMDE - CMH

1 stop15h 08mMultiple Airlines

Deal found 11/25

$407

One-way flights from Columbus to South America
Search for one-way flight options from Columbus to South America. Find affordable one-way fares based on user searches. Data last updated November 26, 2025.

Sun 2/16:15 amCMH - GYE

1 stop18h 06mSpirit Airlines

Deal found 11/25

$123

Fri 1/235:33 amCMH - BOG

1 stop7h 17mSpirit Airlines

Deal found 11/24

$129

Sun 1/255:45 amCMH - CTG

1 stop7h 30mSpirit Airlines

Deal found 11/26

$132

Sun 12/78:33 pmCMH - MDE

1 stop17h 41mSpirit Airlines

Deal found 11/24

$137

Sun 1/254:11 pmCMH - CTG

2 stops21h 04mMultiple Airlines

Deal found 11/26

$137

Sun 2/14:11 pmCMH - GYE

2 stops32h 10mMultiple Airlines

Deal found 11/25

$139

Thu 1/155:33 amCMH - MDE

1 stop8h 22mSpirit Airlines

Deal found 11/25

$161

Tue 12/96:00 amCMH - MDE

2 stops19h 09mSpirit Airlines

Deal found 11/24

$162

Fri 1/236:15 amCMH - BOG

2 stops14h 15mMultiple Airlines

Deal found 11/24

$162

Mon 12/812:36 pmCMH - MDE

2 stops12h 33mMultiple Airlines

Deal found 11/24

$169

Wed 12/1011:14 amCMH - MDE

3 stops51h 00mSpirit Airlines

Deal found 11/24

$177

Thu 1/1512:00 pmCMH - MDE

2 stops26h 15mMultiple Airlines

Deal found 11/25

$183

Cheap flight deals from Columbus to South America

Round-trip from	$297 (Orbitz)
One-way from	$123 (Orbitz)

From Columbus to South America

Search Deals

One-way flight from Columbus to South America

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Columbus to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

ColumbusBogotá

CMH - BOG

CMHBOG

Columbus

Mon 1/26

5:33 am-12:50 pm

1 stop7h 17m

Bogotá El Dorado

Wed 1/28

3:06 pm-9:40 am

1 stop18h 34m

$301

ColumbusCartagena

CMH - CTG

CMHCTG

Columbus

Mon 1/26

6:15 am-1:15 pm

1 stop7h 00m

Cartagena Rafael Nunez

Thu 1/29

2:21 pm-10:13 pm

1 stop7h 52m

$310

ColumbusMedellín

CMH - MDE

CMHMDE

Columbus

Mon 1/19

6:15 am-2:15 pm

1 stop8h 00m

Medellín Jose Maria Cordova Intl

Fri 1/23

2:50 pm-11:58 pm

1 stop9h 08m

$317

ColumbusBogotá

CMH - BOG

CMHBOG

Columbus

Thu 1/15

5:33 am-12:50 pm

1 stop7h 17m

Bogotá El Dorado

Wed 1/21

1:45 pm-11:58 pm

1 stop10h 13m

$319

ColumbusBogotá

CMH - BOG

CMHBOG

Columbus

Sun 2/22

5:40 am-12:47 pm

1 stop7h 07m

Bogotá El Dorado

Tue 3/3

1:47 pm-11:53 pm

1 stop10h 06m

$346

ColumbusGuayaquil

CMH - GYE

CMHGYE

Columbus

Mon 1/26

6:15 am-12:21 am

1 stop18h 06m

Guayaquil Jose Joaquin de Olmedo

Tue 1/27

1:26 am-11:58 pm

2 stops22h 32m

$349

ColumbusMedellín

CMH - MDE

CMHMDE

Columbus

Mon 12/8

8:33 pm-2:14 pm

1 stop17h 41m

Medellín Jose Maria Cordova Intl

Wed 12/10

2:05 am-10:14 pm

1 stop20h 09m

$363

ColumbusCartagena

CMH - CTG

CMHCTG

Columbus

Tue 1/20

5:33 am-1:15 pm

2 stops7h 42m

Cartagena Rafael Nunez

Thu 1/29

2:21 pm-10:13 pm

1 stop7h 52m

$363

ColumbusMedellín

CMH - MDE

CMHMDE

Columbus

Mon 1/19

6:15 am-2:15 pm

1 stop8h 00m

Medellín Jose Maria Cordova Intl

Thu 1/22

4:53 am-11:58 pm

2 stops19h 05m

$371

ColumbusBogotá

CMH - BOG

CMHBOG

Columbus

Sat 1/31

5:33 am-2:07 pm

2 stops8h 34m

Bogotá El Dorado

Sun 2/8

1:45 pm-11:58 pm

1 stop10h 13m

$376

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/25

Showing 1-10 of 60 results

...

Best time to book a flight from Columbus to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Columbus with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Columbus to South America

What is the cheapest month to book a flight from Columbus to South America?

Currently, February is the cheapest month in which you can book a flight from Columbus to South America (average of $257). Flying from Columbus to South America in June is currently the most expensive (average of $381). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CMH to SA?

It’s typically best to fly out from Columbus to South America in the evening. Doing so could potentially save you 12% on the flight price compared to flying in the afternoon, which is usually more expensive.

What is the cheapest day to fly from Columbus to South America?

Travelers seeking maximum savings on their Columbus to South America flight should consider departing on Tuesday mornings when fares are most often at their lowest. Friday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South America

See what other customers who have flown with Delta, LATAM Airlines, and United Airlines from Columbus to South America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Delta

7.9

Good

8,001 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Delta

7.9

Good

8,001 reviews

Delta

7.9

Good

8,001 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

LATAM Airlines

7.5

Good

1,886 reviews

Delta

7.9

Good

8,001 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

United Airlines

7.4

Good

9,047 reviews

Delta

7.9

Good

8,001 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

American Airlines

7.2

Good

11,038 reviews

Delta

7.9

Good

8,001 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

Spirit Airlines

6.3

Okay

8,160 reviews

Delta

7.9

Good

8,001 reviews

Reviews

1 / 20

6.0

Good

Jim,Nov 2025

AVL - ATL

Related info for your journey

How long is the flight from Columbus to South America?
For as low as $301, Spirit Airlines can have you in South America from Columbus in 7h 17m. There are 2497 mi between Columbus and South America.
What are the most popular routes from Columbus to South America?
Most travelers choose Columbus - Medellín Jose Maria Cordova Intl, Columbus - Cartagena Rafael Nunez or Columbus - Buenos Aires Ministro Pistarini when deciding on the best route from Columbus to South America.
Can I find deals for flights from Columbus to South America that include hotel bookings?
Yes. In addition to deals on Columbus to South America flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Columbus to South America?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Columbus to South America.
Can I find deals for business class flights from Columbus to South America?
Yes. Cheapflights offers flight deals from Columbus to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Columbus to South America?
Currently, February is the cheapest month in which you can book a flight from Columbus to South America (average of $257). Flying from Columbus to South America in June is currently the most expensive (average of $381). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Top 6 airlines flying from Columbus to South America

Airline	Cheapest	Average	Flexibility	On-time
Spirit Airlines	Cheapest$261	Average$395	FlexibilityNo cancel fee	On-time65%
American Airlines	Cheapest$443	Average$787	FlexibilityNo cancel fee	On-time71%
United Airlines	Cheapest$534	Average$1,107	FlexibilityNo cancel fee	On-time69%
Delta	Cheapest$552	Average$887	FlexibilityNo cancel fee	On-timeN/A
LATAM Airlines	Cheapest$555	Average$823	FlexibilityNo cancel fee	On-time81%
Air Canada	Cheapest$744	Average$956	FlexibilityNo cancel fee	On-time67%

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$123+ Cheap flights from Columbus to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/1. Fares are subject to change and may not be available on all flights or dates of travel.

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Find flight deals from Columbus to South America

Cheapest flights from Columbus to South AmericaExplore the most affordable flight options available from Columbus to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

Explore the most affordable flight options available from Columbus to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

Cheap flight deals from Columbus to South America

Keep the following information in mind while searching for Columbus to South America flight deals. Data was last updated November 26, 2025.

Round-trip from

One-way from

Cheapflights Fare Finder

Use the filters below to find and compare flights from Columbus to South America that are best for you.

Best time to book a flight from Columbus to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Columbus with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Columbus to South America

What is the cheapest month to book a flight from Columbus to South America?

What is the cheapest time of day to fly from CMH to SA?

Find hourly flight availability from Columbus to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 26, 2025.

What is the cheapest day to fly from Columbus to South America?

Use this chart to determine the cheapest time to fly round-trip from Columbus to South America. Price data was last updated on December 16, 2024.

Reviews of airlines servicing South America

See what other customers who have flown with Delta, LATAM Airlines, and United Airlines from Columbus to South America have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Columbus to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Columbus to South America?

What are the most popular routes from Columbus to South America?

Can I find deals for flights from Columbus to South America that include hotel bookings?

How can I find direct flights from Columbus to South America?

Can I find deals for business class flights from Columbus to South America?

What is the cheapest month to book a flight from Columbus to South America?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Columbus to South America

See prices for flight routes from nearby airports that may be better suited for you.

Top 6 airlines flying from Columbus to South America

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Cheapest flights from Columbus to South America
Explore the most affordable flight options available from Columbus to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.