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South America

$140+ Cheap flights from Charleston (CHS) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/1. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BOG
Nov 15 — Nov 221
Sat 11/15
Sat 11/22
1 adult, Economy
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Find flight deals from Charleston to South America

Cheapest flights from Charleston to South America
Explore the most affordable flight options available from Charleston to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 16, 2025.

This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/256:50 amCHS - MDE
1 stop7h 13mSpirit Airlines
Wed 12/102:15 amMDE - CHS
1 stop7h 30mSpirit Airlines
Deal found 10/16$266
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/246:50 amCHS - MDE
1 stop7h 13mSpirit Airlines
Thu 12/113:10 pmMDE - CHS
1 stop18h 35mSpirit Airlines
Deal found 10/16$279
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/246:50 amCHS - MDE
1 stop7h 13mSpirit Airlines
Thu 12/42:15 amMDE - CHS
1 stop7h 30mSpirit Airlines
Deal found 10/16$293
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/256:50 amCHS - MDE
1 stop7h 13mSpirit Airlines
Fri 12/53:10 pmMDE - CHS
2 stops19h 50mSpirit Airlines
Deal found 10/16$313
This Spirit deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Spirit is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/37:00 amCHS - BOG
1 stop7h 10mSpirit Airlines
Sun 11/163:15 pmBOG - CHS
1 stop7h 27mSpirit Airlines
Deal found 10/15$322
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/76:11 pmCHS - CTG
2 stops43h 04mSpirit Airlines
Thu 11/132:20 pmCTG - CHS
1 stop8h 22mSpirit Airlines
Deal found 10/16$323
This Cheapflightsfares deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/710:40 amCHS - GYE
1 stop13h 03mSpirit Airlines
Sat 12/1312:59 amGYE - CHS
1 stop8h 46mSpirit Airlines
Deal found 10/16$328
This KAYAK deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/256:50 amCHS - MDE
1 stop7h 13mSpirit Airlines
Sat 12/611:50 amMDE - CHS
2 stops21h 55mSpirit Airlines
Deal found 10/16$337
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/286:50 amCHS - MDE
1 stop7h 13mSpirit Airlines
Wed 12/102:15 amMDE - CHS
1 stop7h 30mSpirit Airlines
Deal found 10/16$341
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/256:50 amCHS - MDE
1 stop7h 13mMultiple Airlines
Mon 12/811:50 amMDE - CHS
1 stop20h 47mMultiple Airlines
Deal found 10/16$346
This KAYAK deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/246:50 amCHS - MDE
1 stop7h 13mSpirit Airlines
Sat 12/611:50 amMDE - CHS
2 stops21h 55mSpirit Airlines
Deal found 10/16$348
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/17:55 pmCHS - BOG
2 stops19h 15mSpirit Airlines
Thu 11/133:15 pmBOG - CHS
1 stop7h 27mSpirit Airlines
Deal found 10/15$354

Cheap flight deals from Charleston to South America

Keep the following information in mind while searching for Charleston to South America flight deals. Data was last updated October 16, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$266
(Kiwi.com)

One-way from

$140
(Kiwi.com)
Provider with most accurate pricing for Charleston-Sao Paulo (SAO) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Charleston-Sao Paulo (SAO) flights.
Search Deals
From Charleston to South America
Search Deals
One-way flight from Charleston to South America
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
Use the filters below to find and compare flights from Charleston to South America that are best for you.

Fly from

Charleston

Fly to

South America

Route

Depart

Return

Price

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Mon 11/24

6:50 am-2:03 pm

1 stop7h 13m

Medellín Jose Maria Cordova Intl

Thu 12/11

11:50 am-9:45 am

2 stops21h 55m

$317

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Fri 11/7

6:11 pm-1:15 pm

2 stops43h 04m

Cartagena Rafael Nunez

Thu 11/13

2:20 pm-10:42 pm

1 stop8h 22m

$323

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Sun 12/7

10:40 am-11:43 pm

1 stop13h 03m

Guayaquil Jose Joaquin de Olmedo

Sat 12/13

12:59 am-9:45 am

1 stop8h 46m

$328

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Tue 11/25

6:50 am-2:03 pm

1 stop7h 13m

Medellín Jose Maria Cordova Intl

Mon 12/8

11:50 am-8:37 am

1 stop20h 47m

$346

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Thu 11/27

2:59 pm-2:03 pm

2 stops23h 04m

Medellín Jose Maria Cordova Intl

Sun 12/7

2:15 am-9:45 am

1 stop7h 30m

$362

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Fri 10/31

3:33 pm-12:00 pm

1 stop21h 27m

Bogotá El Dorado

Mon 11/17

1:55 pm-8:37 am

1 stop18h 42m

$362

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Tue 1/27

11:35 am-2:50 pm

1 stop27h 15m

Cartagena Rafael Nunez

Sun 2/1

3:55 pm-10:45 am

1 stop18h 50m

$363

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Sat 11/29

6:50 am-2:03 pm

1 stop7h 13m

Medellín Jose Maria Cordova Intl

Thu 12/4

2:15 am-9:45 am

1 stop7h 30m

$371

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Thu 11/27

2:59 pm-2:01 pm

1 stop23h 02m

Medellín Jose Maria Cordova Intl

Thu 12/4

2:15 am-9:45 am

1 stop7h 30m

$377

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Thu 11/6

2:59 pm-1:00 pm

1 stop22h 01m

Bogotá El Dorado

Mon 11/17

1:55 pm-8:37 am

1 stop18h 42m

$390

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/15

Showing 1-10 of 60 results
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Best time to book a flight from Charleston to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to South America

What is the cheapest month to book a flight from Charleston to South America?

Currently, September is the cheapest month in which you can book a flight from Charleston to South America (average of $176). Flying from Charleston to South America in May is currently the most expensive (average of $530). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from CHS to SA?

Find hourly flight availability from Charleston to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 16, 2025.

It’s optimal to fly from Charleston to South America in the afternoon. By choosing this option you can save up to 9% on the cost of your flight, compared to a flight in the evening.

What is the cheapest day to fly from Charleston to South America?

Use this chart to determine the cheapest time to fly round-trip from Charleston to South America. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Charleston to South America flight should consider departing on Wednesday mornings when fares are most often at their lowest. Friday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated October 16, 2025.
See what other customers who have flown with Delta, LATAM Airlines, and American Airlines from Charleston to South America have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
Delta
8.0
Very good
7,982 reviews
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
LATAM Airlines
7.5
Good
1,866 reviews
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.
American Airlines
7.2
Good
11,040 reviews
Delta
8.0
Very good
7,982 reviews

Comfort

7.9

Crew

8.5

Overall

8.0

Boarding

8.2

Entertainment

7.9

Food

7.3

Reviews

1 / 20
8.0
Excellent

Matthew,Oct 2025

GSP - ATL

This is always a full flight since it is the connecting route to primary destinations through Atlanta. That said, the crew handles the full load well. Not much more to say, it is a short flight with no in-flight services due to the length.

Related info for your journey

Find useful and relevant information for your journey from Charleston to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Charleston to South America?

    For a flight from Charleston to South America, you will be flying from Charleston. Charleston (CHS) is just 10.2 mi from the center of the city.

  • How long is the flight from Charleston to South America?

    Airlines like Spirit Airlines, JetBlue, and Delta fly from Charleston to South America in about 7h 13m. The time it takes to get you to your destination can typically vary by up to 23h 56m. Charleston and South America are separated by a distance of 1869 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Charleston to South America one-way?

    The cheapest airlines for a one-way flight from Charleston to South America are Spirit Airlines ($140), American Airlines ($164), and JetBlue ($339).

  • What are the most popular routes from Charleston to South America?

    Most travelers choose Charleston - Bogotá El Dorado, Charleston - Lima J Chavez Intl or Charleston - Sao Paulo Guarulhos Intl when deciding on the best route from Charleston to South America.

  • Can I find deals for flights from Charleston to South America that include hotel bookings?

    Yes. In addition to deals on Charleston to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to South America.

  • Can I find deals for business class flights from Charleston to South America?

    Yes. Cheapflights offers flight deals from Charleston to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to South America?

    Currently, September is the cheapest month in which you can book a flight from Charleston to South America (average of $176). Flying from Charleston to South America in May is currently the most expensive (average of $530). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Charleston to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Charleston to South America

Discover the top 3 airlines that operate flights from Charleston to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$301Average$893FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$458Average$762FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$491Average$910FlexibilityNo cancel feeOn-time81%

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