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South America

$125+ Cheap flights from Charleston (CHS) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/24. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BOG
Mar 16 — Mar 231
Mon 3/16
Mon 3/23
1 adult, Economy
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Cheap flight deals from Charleston to South America

Cheapest flights from Charleston to South America
Explore the most affordable flight options available from Charleston to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 14, 2026.

This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/278:07 am
CHS
-
CTG
1 stop28h 59m
Spirit Airlines
Fri 4/31:14 pm
CTG
-
CHS
1 stop7h 59m
Spirit Airlines
Deal found 2/10$330
This Cheapflightsfares deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/138:07 am
CHS
-
BOG
1 stop6h 04m
Spirit Airlines
Sun 3/152:10 pm
BOG
-
CHS
1 stop7h 03m
Spirit Airlines
Deal found 2/10$334
This FlightHub deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:00 am
CHS
-
CTG
1 stop6h 05m
Spirit Airlines
Sat 4/181:11 pm
CTG
-
CHS
1 stop7h 38m
Spirit Airlines
Deal found 2/12$340
This FlightHub deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:00 am
CHS
-
CTG
1 stop6h 05m
Spirit Airlines
Sun 4/191:11 pm
CTG
-
CHS
1 stop7h 38m
Spirit Airlines
Deal found 2/11$364
This Expedia deal was found by Cheapflights users on 2/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/308:07 am
CHS
-
CTG
1 stop4h 59m
Spirit Airlines
Mon 4/61:14 pm
CTG
-
CHS
1 stop7h 59m
Spirit Airlines
Deal found 2/13$370
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/98:07 am
CHS
-
MDE
1 stop14h 18m
Multiple Airlines
Wed 4/151:00 pm
MDE
-
CHS
1 stop7h 49m
Multiple Airlines
Deal found 2/12$396
This Expedia deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/298:07 am
CHS
-
CTG
1 stop4h 59m
Spirit Airlines
Sun 4/51:14 pm
CTG
-
CHS
1 stop7h 59m
Spirit Airlines
Deal found 2/12$401
This Kiwi.com deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/278:07 am
CHS
-
CTG
1 stop28h 59m
Multiple Airlines
Fri 4/310:01 pm
CTG
-
CHS
2 stops23h 12m
Multiple Airlines
Deal found 2/10$413
This Kiwi.com deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/18:07 am
CHS
-
MDE
1 stop14h 18m
Multiple Airlines
Mon 4/61:00 pm
MDE
-
CHS
1 stop8h 13m
Multiple Airlines
Deal found 2/12$418
This Kiwi.com deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/223:26 pm
CHS
-
BOG
2 stops18h 54m
Multiple Airlines
Mon 4/274:05 pm
BOG
-
CHS
1 stop15h 33m
Multiple Airlines
Deal found 2/14$436
This Kiwi.com deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/268:07 am
CHS
-
CTG
1 stop28h 59m
Spirit Airlines
Tue 3/311:14 pm
CTG
-
CHS
1 stop7h 59m
Spirit Airlines
Deal found 2/11$440
This Travelocity deal was found by Cheapflights users on 2/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:08 pm
CHS
-
CTG
1 stop17h 52m
JetBlue
Mon 5/112:05 pm
CTG
-
CHS
1 stop28h 08m
JetBlue
Deal found 2/12$443

Find flight deals from Charleston to South America

Keep the following information in mind while searching for Charleston to South America flight deals. Data was last updated February 14, 2026.

Round-trip from

$330
(Kiwi.com)

One-way from

$125
(Cheapflightsfares)

Popular in

May

Cheapest in

September

Average price

$608
From Charleston to South America
Search Deals
One-way flight from Charleston to South America
Search Deals
Highest demand for flights based on searches. 10% potential increase in price ($72 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 14, 2026.
Use the filters below to find and compare flights from Charleston to South America that are best for you.

Fly from

Charleston

Fly to

South America

Route

Depart

Return

Price

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Fri 3/27

8:07 am-12:06 pm

1 stop28h 59m

Cartagena Rafael Nunez

Fri 4/3

1:14 pm-10:13 pm

1 stop7h 59m

$330

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Fri 3/13

8:07 am-1:11 pm

1 stop6h 04m

Bogotá El Dorado

Sun 3/15

2:10 pm-10:13 pm

1 stop7h 03m

$334

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Thu 4/16

7:00 am-12:05 pm

1 stop6h 05m

Cartagena Rafael Nunez

Sat 4/18

1:11 pm-9:49 pm

1 stop7h 38m

$340

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Thu 4/16

7:00 am-12:05 pm

1 stop6h 05m

Cartagena Rafael Nunez

Sun 4/19

1:11 pm-9:49 pm

1 stop7h 38m

$364

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Mon 3/30

8:07 am-12:06 pm

1 stop4h 59m

Cartagena Rafael Nunez

Mon 4/6

1:14 pm-10:13 pm

1 stop7h 59m

$370

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Thu 4/9

8:07 am-9:25 pm

1 stop14h 18m

Medellín Jose Maria Cordova Intl

Wed 4/15

1:00 pm-9:49 pm

1 stop7h 49m

$396

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Sun 3/29

8:07 am-12:06 pm

1 stop4h 59m

Cartagena Rafael Nunez

Sun 4/5

1:14 pm-10:13 pm

1 stop7h 59m

$401

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Fri 3/27

8:07 am-12:06 pm

1 stop28h 59m

Cartagena Rafael Nunez

Fri 4/3

10:01 pm-10:13 pm

2 stops23h 12m

$413

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Wed 4/1

8:07 am-9:25 pm

1 stop14h 18m

Medellín Jose Maria Cordova Intl

Mon 4/6

1:00 pm-10:13 pm

1 stop8h 13m

$418

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Thu 3/26

8:07 am-12:06 pm

1 stop28h 59m

Cartagena Rafael Nunez

Tue 3/31

1:14 pm-10:13 pm

1 stop7h 59m

$440

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/10

Showing 1-10 of 60 results
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Best time to book a flight from Charleston to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to South America

What is the cheapest month to book a flight from Charleston to South America?

Currently, November is the cheapest month in which you can book a flight from Charleston to South America (average of $113). Flying from Charleston to South America in May is currently the most expensive (average of $546). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated February 14, 2026.
See what other customers who have flown with Delta, LATAM Airlines, and American Airlines from Charleston to South America have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,205 reviews

Crew

8.5

Entertainment

7.8

Comfort

7.9

Boarding

8.1

Food

7.2

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,205 reviews
Delta
7.9
Good
8,205 reviews

Crew

8.5

Entertainment

7.8

Comfort

7.9

Boarding

8.1

Food

7.2

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,919 reviews
Delta
7.9
Good
8,205 reviews

Crew

8.5

Entertainment

7.8

Comfort

7.9

Boarding

8.1

Food

7.2

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,297 reviews
Delta
7.9
Good
8,205 reviews

Crew

8.5

Entertainment

7.8

Comfort

7.9

Boarding

8.1

Food

7.2

Overall

7.9

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Charleston to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Charleston to South America?

    For a flight from Charleston to South America, you will be flying from Charleston. Charleston (CHS) is just 10.2 mi from the center of the city.

  • How long is the flight from Charleston to South America?

    Airlines like Spirit Airlines, American Airlines, and LATAM Airlines fly from Charleston to South America in about 17h 10m. The time it takes to get you to your destination can typically vary by up to 11h 49m. Charleston and South America are separated by a distance of 2282 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Charleston to South America one-way?

    The cheapest airlines for a one-way flight from Charleston to South America are American Airlines ($296), Delta ($356), and LATAM Airlines ($356).

  • What are the most popular routes from Charleston to South America?

    Most travelers choose Charleston - Lima J Chavez Intl, Charleston - Medellín Jose Maria Cordova Intl or Charleston - Buenos Aires Ministro Pistarini when deciding on the best route from Charleston to South America.

  • Can I find deals for flights from Charleston to South America that include hotel bookings?

    Yes. In addition to deals on Charleston to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to South America.

  • Can I find deals for business class flights from Charleston to South America?

    Yes. Cheapflights offers flight deals from Charleston to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to South America?

    Currently, November is the cheapest month in which you can book a flight from Charleston to South America (average of $113). Flying from Charleston to South America in May is currently the most expensive (average of $546). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Charleston to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Charleston to South America

Discover the top 3 airlines that operate flights from Charleston to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 14, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$301Average$881FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$458Average$795FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$542Average$732FlexibilityNo cancel feeOn-time81%

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