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South America

$104+ Cheap flights from Charleston (CHS) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/28. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BOG
Mar 7 — Mar 141
Sat 3/7
Sat 3/14
1 adult, Economy
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Cheap flight deals from Charleston to South America

Cheapest flights from Charleston to South America
Explore the most affordable flight options available from Charleston to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 5, 2026.

This Expedia deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/188:07 am
CHS
-
MDE
1 stop6h 15m
Spirit Airlines
Wed 3/252:17 pm
MDE
-
CHS
1 stop6h 56m
Spirit Airlines
Deal found 2/1$252
This Travelocity deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:00 am
CHS
-
CTG
1 stop6h 13m
Spirit Airlines
Sat 4/181:21 pm
CTG
-
CHS
1 stop8h 20m
Spirit Airlines
Deal found 2/2$254
This Cheapflightsfares deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/278:07 am
CHS
-
MDE
1 stop17h 14m
Spirit Airlines
Fri 4/32:17 pm
MDE
-
CHS
1 stop6h 56m
Spirit Airlines
Deal found 2/4$272
This Travelocity deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:00 am
CHS
-
CTG
1 stop6h 13m
Spirit Airlines
Sun 4/191:21 pm
CTG
-
CHS
1 stop8h 20m
Spirit Airlines
Deal found 2/2$278
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/76:35 pm
CHS
-
GYE
1 stop28h 29m
Spirit Airlines
Fri 3/1311:59 pm
GYE
-
CHS
1 stop21h 14m
Spirit Airlines
Deal found 2/1$285
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:35 pm
CHS
-
GYE
1 stop29h 29m
Spirit Airlines
Fri 3/1311:59 pm
GYE
-
CHS
1 stop21h 14m
Spirit Airlines
Deal found 2/1$287
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:35 pm
CHS
-
GYE
1 stop29h 29m
Spirit Airlines
Wed 3/1111:59 pm
GYE
-
CHS
1 stop21h 14m
Spirit Airlines
Deal found 2/1$289
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/178:07 am
CHS
-
GYE
1 stop15h 57m
Spirit Airlines
Fri 3/2711:59 pm
GYE
-
CHS
1 stop21h 14m
Spirit Airlines
Deal found 2/3$295
This Priceline deal was found by Cheapflights users on 2/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/228:07 am
CHS
-
CTG
1 stop4h 59m
Spirit Airlines
Tue 3/241:14 pm
CTG
-
CHS
1 stop7h 59m
Spirit Airlines
Deal found 2/4$299
This Kiwi.com deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/98:07 am
CHS
-
GYE
1 stop15h 57m
Spirit Airlines
Mon 4/1311:59 pm
GYE
-
CHS
1 stop21h 14m
Spirit Airlines
Deal found 2/3$301
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/76:35 pm
CHS
-
GYE
1 stop28h 29m
Spirit Airlines
Thu 3/1211:59 pm
GYE
-
CHS
1 stop21h 14m
Spirit Airlines
Deal found 2/1$304
This Kiwi.com deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/76:35 pm
CHS
-
GYE
1 stop28h 29m
Spirit Airlines
Sat 3/1411:59 pm
GYE
-
CHS
1 stop21h 14m
Spirit Airlines
Deal found 2/1$305

Find flight deals from Charleston to South America

Keep the following information in mind while searching for Charleston to South America flight deals. Data was last updated February 5, 2026.

Round-trip from

$252
(Expedia)

One-way from

$104
(Cheapflightsfares)

Popular in

May

Cheapest in

September

Average price

$663
From Charleston to South America
Search Deals
One-way flight from Charleston to South America
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($56 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
Use the filters below to find and compare flights from Charleston to South America that are best for you.

Fly from

Charleston

Fly to

South America

Route

Depart

Return

Price

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Wed 3/18

8:07 am-1:22 pm

1 stop6h 15m

Medellín Jose Maria Cordova Intl

Wed 3/25

2:17 pm-10:13 pm

1 stop6h 56m

$252

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Fri 3/27

8:07 am-12:21 am

1 stop17h 14m

Medellín Jose Maria Cordova Intl

Fri 4/3

2:17 pm-10:13 pm

1 stop6h 56m

$272

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Thu 4/16

7:00 am-12:13 pm

1 stop6h 13m

Cartagena Rafael Nunez

Sat 4/18

1:21 pm-10:41 pm

1 stop8h 20m

$275

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Mon 3/2

6:35 pm-12:04 am

1 stop29h 29m

Guayaquil Jose Joaquin de Olmedo

Wed 3/11

11:59 pm-10:13 pm

1 stop21h 14m

$289

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Sun 3/22

8:07 am-12:06 pm

1 stop4h 59m

Cartagena Rafael Nunez

Tue 3/24

1:14 pm-10:13 pm

1 stop7h 59m

$299

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Thu 4/16

7:00 am-12:13 pm

1 stop6h 13m

Cartagena Rafael Nunez

Sun 4/19

1:21 pm-10:41 pm

1 stop8h 20m

$304

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Mon 3/2

6:35 pm-2:10 pm

1 stop19h 35m

Bogotá El Dorado

Mon 3/9

2:05 pm-4:05 pm

2 stops25h 00m

$308

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Sat 2/28

6:35 pm-1:10 pm

1 stop18h 35m

Cartagena Rafael Nunez

Tue 3/10

1:21 pm-4:05 pm

2 stops25h 44m

$311

CharlestonLima

CHS - LIM

CHSLIM

Charleston

Sat 3/21

8:07 am-9:35 pm

1 stop14h 28m

Lima J Chavez Intl

Thu 3/26

10:35 pm-10:13 pm

1 stop22h 38m

$320

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Thu 3/5

6:35 pm-2:10 pm

1 stop19h 35m

Bogotá El Dorado

Mon 3/9

2:05 pm-4:05 pm

2 stops25h 00m

$324

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/2

Showing 1-10 of 60 results
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Best time to book a flight from Charleston to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to South America

What is the cheapest month to book a flight from Charleston to South America?

Currently, November is the cheapest month in which you can book a flight from Charleston to South America (average of $113). Flying from Charleston to South America in May is currently the most expensive (average of $530). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated February 5, 2026.
See what other customers who have flown with Delta, LATAM Airlines, and American Airlines from Charleston to South America have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,146 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,146 reviews
Delta
7.9
Good
8,146 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,918 reviews
Delta
7.9
Good
8,146 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,222 reviews
Delta
7.9
Good
8,146 reviews

Comfort

7.9

Entertainment

7.8

Overall

7.9

Food

7.2

Boarding

8.1

Crew

8.5

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Charleston to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Charleston to South America?

    For a flight from Charleston to South America, you will be flying from Charleston. Charleston (CHS) is just 10.2 mi from the center of the city.

  • How long is the flight from Charleston to South America?

    Airlines like Spirit Airlines fly from Charleston to South America in about 6h 15m. The time it takes to get you to your destination can typically vary by up to . Charleston and South America are separated by a distance of 1869 mi.

  • What are the cheapest airlines to fly from Charleston to South America one-way?

    The cheapest airlines for a one-way flight from Charleston to South America are American Airlines ($296), Delta ($356), and LATAM Airlines ($356).

  • What are the most popular routes from Charleston to South America?

    Most travelers choose Charleston - Lima J Chavez Intl, Charleston - Cartagena Rafael Nunez or Charleston - Bogotá El Dorado when deciding on the best route from Charleston to South America.

  • Can I find deals for flights from Charleston to South America that include hotel bookings?

    Yes. In addition to deals on Charleston to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to South America.

  • Can I find deals for business class flights from Charleston to South America?

    Yes. Cheapflights offers flight deals from Charleston to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to South America?

    Currently, November is the cheapest month in which you can book a flight from Charleston to South America (average of $113). Flying from Charleston to South America in May is currently the most expensive (average of $530). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Charleston to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Charleston to South America

Discover the top 3 airlines that operate flights from Charleston to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 5, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$301Average$881FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$458Average$793FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$542Average$732FlexibilityNo cancel feeOn-time81%

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