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South America

$142+ Cheap flights from Charleston (CHS) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/28. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BOG
Apr 10 — Apr 171
Fri 4/10
Fri 4/17
1 adult, Economy
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Cheap flight deals from Charleston to South America

Cheapest flights from Charleston to South America
Explore the most affordable flight options available from Charleston to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 11, 2026.

This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/258:07 am
CHS
-
GYE
1 stop15h 57m
Spirit Airlines
Mon 3/3011:59 pm
GYE
-
CHS
1 stop21h 14m
Spirit Airlines
Deal found 3/7$330
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/258:07 am
CHS
-
GYE
1 stop15h 57m
Spirit Airlines
Tue 3/3111:59 pm
GYE
-
CHS
1 stop21h 14m
Spirit Airlines
Deal found 3/7$345
This American Airlines deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:00 am
CHS
-
GYE
2 stops17h 12m
American Airlines
Sun 5/32:31 pm
GYE
-
CHS
1 stop19h 03m
American Airlines
Deal found 3/9$351
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/258:07 am
CHS
-
GYE
1 stop15h 57m
Multiple Airlines
Tue 3/3111:59 pm
GYE
-
CHS
2 stops31h 39m
Multiple Airlines
Deal found 3/7$394
This KAYAK deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/218:07 am
CHS
-
GYE
1 stop15h 57m
Spirit Airlines
Sat 3/2811:59 pm
GYE
-
CHS
1 stop21h 14m
Spirit Airlines
Deal found 3/7$398
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/255:16 pm
CHS
-
GYE
2 stops30h 48m
Multiple Airlines
Mon 3/3011:59 pm
GYE
-
CHS
1 stop21h 14m
Multiple Airlines
Deal found 3/7$409
This Avianca deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/15:59 pm
CHS
-
GYE
1 stop17h 41m
Multiple Airlines
Sun 5/38:00 pm
GYE
-
CHS
1 stop19h 57m
Multiple Airlines
Deal found 3/9$413
This Kiwi.com deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/134:34 pm
CHS
-
MDE
1 stop21h 26m
Multiple Airlines
Sat 5/231:55 pm
MDE
-
CHS
1 stop17h 43m
Multiple Airlines
Deal found 3/9$448
This KAYAK deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/18:21 pm
CHS
-
GYE
2 stops18h 10m
GOL
Sun 5/32:31 pm
GYE
-
CHS
2 stops20h 13m
GOL
Deal found 3/9$457
This KAYAK deal was found by Cheapflights users on 3/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/268:09 pm
CHS
-
GYE
1 stop26h 03m
GOL
Tue 5/266:00 am
GYE
-
CHS
2 stops16h 00m
GOL
Deal found 3/9$458
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/148:07 am
CHS
-
BOG
2 stops28h 48m
Multiple Airlines
Wed 3/1812:50 pm
BOG
-
CHS
1 stop18h 48m
Multiple Airlines
Deal found 3/7$481
This Kiwi.com deal was found by Cheapflights users on 3/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/213:01 pm
CHS
-
BOG
1 stop12h 44m
Multiple Airlines
Tue 4/289:30 pm
BOG
-
CHS
2 stops41h 55m
Multiple Airlines
Deal found 3/7$488

Find flight deals from Charleston to South America

Keep the following information in mind while searching for Charleston to South America flight deals. Data was last updated March 11, 2026.

Round-trip from

$330
(Kiwi.com)

One-way from

$142
(Cheapflightsfares)

Popular in

July

Cheapest in

September

Average price

$523
From Charleston to South America
Search Deals
One-way flight from Charleston to South America
Search Deals
Highest demand for flights based on searches. 17% potential increase in price ($134 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($23 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in March 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
Use the filters below to find and compare flights from Charleston to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Sat 3/21

8:07 am-11:04 pm

1 stop15h 57m

Guayaquil Jose Joaquin de Olmedo

Sat 3/28

11:59 pm-10:13 pm

1 stop21h 14m

$407

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Fri 5/1

5:59 pm-10:40 am

1 stop17h 41m

Guayaquil Jose Joaquin de Olmedo

Sun 5/3

8:00 pm-4:57 pm

1 stop19h 57m

$413

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Wed 5/13

12:05 pm-9:20 am

2 stops22h 15m

Medellín Jose Maria Cordova Intl

Sat 5/23

1:55 pm-8:38 am

1 stop17h 43m

$502

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Fri 5/1

8:21 pm-2:04 pm

2 stops18h 43m

Cartagena Rafael Nunez

Wed 5/6

1:25 pm-12:24 am

1 stop9h 59m

$523

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Tue 4/21

12:05 pm-8:20 pm

2 stops33h 15m

Bogotá El Dorado

Tue 4/28

2:15 pm-11:08 am

2 stops19h 53m

$526

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Mon 4/20

8:21 pm-12:09 pm

2 stops16h 48m

Cartagena Rafael Nunez

Sat 4/25

3:10 pm-12:24 am

1 stop8h 14m

$527

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Tue 4/21

5:20 am-1:20 pm

1 stop9h 00m

Cartagena Rafael Nunez

Tue 4/28

4:25 am-6:52 pm

2 stops13h 27m

$529

CharlestonCartagena

CHS - CTG

CHSCTG

Charleston

Wed 5/27

6:51 pm-2:13 pm

2 stops20h 22m

Cartagena Rafael Nunez

Sun 5/31

3:13 pm-12:08 pm

2 stops19h 55m

$533

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Mon 6/8

8:08 pm-11:20 am

1 stop16h 12m

Bogotá El Dorado

Mon 6/29

6:30 am-11:55 pm

1 stop16h 25m

$535

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Fri 4/24

12:03 pm-9:20 am

2 stops22h 17m

Medellín Jose Maria Cordova Intl

Mon 4/27

1:55 pm-8:38 am

1 stop17h 43m

$537

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/10

Showing 1-10 of 60 resultsSorted by cheapest first
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6

Best time to book a flight from Charleston to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to South America

What is the cheapest month to book a flight from Charleston to South America?

Currently, November is the cheapest month in which you can book a flight from Charleston to South America (average of $113). Flying from Charleston to South America in May is currently the most expensive (average of $546). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated March 11, 2026.
See what other customers who have flown with Delta,LATAM Airlines, andAmerican Airlines from Charleston to South America have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,278 reviews

Overall

7.9

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,278 reviews
Delta
7.9
Good
8,278 reviews

Overall

7.9

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.4
Good
1,918 reviews
Delta
7.9
Good
8,278 reviews

Overall

7.9

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.1
Good
11,421 reviews
Delta
7.9
Good
8,278 reviews

Overall

7.9

Comfort

7.9

Boarding

8.1

Entertainment

7.8

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Charleston to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Charleston to South America?

    For a flight from Charleston to South America, you will be flying from Charleston. Charleston (CHS) is just 10.2 mi from the center of the city.

  • How long is the flight from Charleston to South America?

    Airlines like Spirit Airlines, American Airlines, and Delta fly from Charleston to South America in about 9h. The time it takes to get you to your destination can typically vary by up to 9h 43m. Charleston and South America are separated by a distance of 1577 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Charleston to South America one-way?

    The cheapest airlines for a one-way flight from Charleston to South America are American Airlines ($296), LATAM Airlines ($356), and Delta ($367).

  • What are the most popular routes from Charleston to South America?

    Most travelers choose Charleston - Lima J Chavez Intl, Charleston - Buenos Aires Ministro Pistarini or Charleston - Santiago Arturo Merino Benitez when deciding on the best route from Charleston to South America.

  • Can I find deals for flights from Charleston to South America that include hotel bookings?

    Yes. In addition to deals on Charleston to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to South America.

  • Can I find deals for business class flights from Charleston to South America?

    Yes. Cheapflights offers flight deals from Charleston to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to South America?

    Currently, November is the cheapest month in which you can book a flight from Charleston to South America (average of $113). Flying from Charleston to South America in May is currently the most expensive (average of $546). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Charleston to South America

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Charleston to South America

Discover the top 3 airlines that operate flights from Charleston to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 11, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$301Average$714FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$465Average$792FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$542Average$732FlexibilityNo cancel feeOn-time81%

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