HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
South America

$113+ Cheap flights from Charleston (CHS) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/26. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — BOG
Mar 23 — Mar 301
Mon 3/23
Mon 3/30
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Charleston to South America with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Charleston to South America

Cheapest flights from Charleston to South America
Explore the most affordable flight options available from Charleston to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 21, 2026.

This American Airlines deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/238:19 pm
CHS
-
GYE
2 stops18h 11m
American Airlines
Mon 3/302:30 pm
GYE
-
CHS
2 stops20h 51m
American Airlines
Deal found 2/21$303
This American Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/178:21 pm
CHS
-
GYE
2 stops18h 10m
American Airlines
Wed 5/202:31 pm
GYE
-
CHS
1 stop8h 53m
American Airlines
Deal found 2/20$315
This Cheapflightsfares deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/87:00 am
CHS
-
MDE
1 stop7h 08m
Spirit Airlines
Sun 5/102:06 pm
MDE
-
CHS
1 stop6h 43m
Spirit Airlines
Deal found 2/20$317
This American Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/148:10 pm
CHS
-
GYE
1 stop18h 23m
American Airlines
Mon 9/212:33 pm
GYE
-
CHS
1 stop18h 47m
American Airlines
Deal found 2/18$317
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/238:07 am
CHS
-
GYE
1 stop15h 57m
Spirit Airlines
Mon 3/3011:59 pm
GYE
-
CHS
1 stop21h 14m
Spirit Airlines
Deal found 2/21$343
This Avianca deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/205:55 pm
CHS
-
GYE
1 stop14h 50m
Multiple Airlines
Sun 5/318:00 pm
GYE
-
CHS
1 stop17h 40m
Multiple Airlines
Deal found 2/20$352
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/17:00 am
CHS
-
GYE
1 stop17h 04m
Spirit Airlines
Wed 6/311:59 pm
GYE
-
CHS
1 stop20h 50m
Spirit Airlines
Deal found 2/20$356
This Kiwi.com deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/238:28 pm
CHS
-
GYE
2 stops27h 36m
Multiple Airlines
Mon 3/3011:59 pm
GYE
-
CHS
1 stop21h 14m
Multiple Airlines
Deal found 2/21$372
This Avianca deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/218:59 pm
CHS
-
GYE
2 stops13h 16m
Multiple Airlines
Sat 3/284:05 pm
GYE
-
CHS
1 stop15h 41m
Multiple Airlines
Deal found 2/20$381
This Kiwi.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/209:50 am
CHS
-
GYE
2 stops14h 14m
Multiple Airlines
Tue 6/211:59 pm
GYE
-
CHS
1 stop20h 50m
Multiple Airlines
Deal found 2/20$383
This Kiwi.com deal was found by Cheapflights users on 2/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/208:07 am
CHS
-
BOG
1 stop30h 04m
Multiple Airlines
Wed 3/256:40 am
BOG
-
CHS
2 stops14h 33m
Multiple Airlines
Deal found 2/17$397
This Avianca deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/2311:00 am
CHS
-
GYE
2 stops13h 30m
Multiple Airlines
Sat 5/304:05 pm
GYE
-
CHS
1 stop17h 10m
Multiple Airlines
Deal found 2/20$408

Find flight deals from Charleston to South America

Keep the following information in mind while searching for Charleston to South America flight deals. Data was last updated February 21, 2026.

Round-trip from

$303
(American Airlines)

One-way from

$113
(Spirit)

Popular in

July

Cheapest in

September

Average price

$608
From Charleston to South America
Search Deals
One-way flight from Charleston to South America
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($124 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($22 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Charleston to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 21, 2026.
Use the filters below to find and compare flights from Charleston to South America that are best for you.

Fly from

Charleston

Fly to

South America

Route

Depart

Return

Price

CharlestonMedellín

CHS - MDE

CHSMDE

Charleston

Fri 5/8

7:00 am-1:08 pm

1 stop7h 08m

Medellín Jose Maria Cordova Intl

Sun 5/10

2:06 pm-9:49 pm

1 stop6h 43m

$317

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Mon 3/23

8:07 am-11:04 pm

1 stop15h 57m

Guayaquil Jose Joaquin de Olmedo

Mon 3/30

11:59 pm-10:13 pm

1 stop21h 14m

$343

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Mon 3/23

8:28 pm-11:04 pm

2 stops27h 36m

Guayaquil Jose Joaquin de Olmedo

Mon 3/30

11:59 pm-10:13 pm

1 stop21h 14m

$372

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Sat 3/21

8:59 pm-9:15 am

2 stops13h 16m

Guayaquil Jose Joaquin de Olmedo

Sat 3/28

4:05 pm-8:46 am

1 stop15h 41m

$381

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Fri 3/20

8:07 am-1:11 pm

1 stop30h 04m

Bogotá El Dorado

Wed 3/25

6:40 am-10:13 pm

2 stops14h 33m

$397

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Fri 3/20

8:07 am-1:11 pm

1 stop6h 04m

Bogotá El Dorado

Wed 3/25

2:10 pm-10:13 pm

1 stop7h 03m

$411

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Wed 5/20

5:00 am-9:12 pm

2 stops17h 12m

Guayaquil Jose Joaquin de Olmedo

Sat 7/11

2:33 pm-10:08 am

2 stops18h 35m

$415

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Fri 8/7

8:27 pm-10:40 am

1 stop15h 13m

Guayaquil Jose Joaquin de Olmedo

Sun 8/16

8:00 pm-10:10 am

1 stop13h 10m

$428

CharlestonGuayaquil

CHS - GYE

CHSGYE

Charleston

Sat 5/23

3:10 pm-6:55 am

2 stops16h 45m

Guayaquil Jose Joaquin de Olmedo

Sat 5/30

4:00 pm-1:53 pm

2 stops20h 53m

$459

CharlestonBogotá

CHS - BOG

CHSBOG

Charleston

Mon 4/27

7:00 am-7:18 am

2 stops25h 18m

Bogotá El Dorado

Fri 5/8

4:05 pm-8:48 am

1 stop15h 43m

$476

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/21

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from Charleston to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Charleston with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Charleston to South America

What is the cheapest month to book a flight from Charleston to South America?

Currently, November is the cheapest month in which you can book a flight from Charleston to South America (average of $113). Flying from Charleston to South America in May is currently the most expensive (average of $546). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated February 21, 2026.
See what other customers who have flown with Delta, LATAM Airlines, and American Airlines from Charleston to South America have to say. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,228 reviews

Entertainment

7.8

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
Delta
7.9
Good
8,228 reviews
Delta
7.9
Good
8,228 reviews

Entertainment

7.8

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
LATAM Airlines
7.5
Good
1,921 reviews
Delta
7.9
Good
8,228 reviews

Entertainment

7.8

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.
American Airlines
7.2
Good
11,334 reviews
Delta
7.9
Good
8,228 reviews

Entertainment

7.8

Boarding

8.1

Overall

7.9

Comfort

7.9

Crew

8.5

Food

7.2

Reviews

1 / 20
6.0
Good

Jim,Nov 2025

AVL - ATL

The exit row seats without a seat in front are great for leg room but don’t have a fold out entertainment console so you’re forced to use the screen several feet in front of you (there is, at least, a remote). Best to bring a tablet loaded with entertainment or a book.

Related info for your journey

Find useful and relevant information for your journey from Charleston to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Charleston to South America?

    For a flight from Charleston to South America, you will be flying from Charleston. Charleston (CHS) is just 10.2 mi from the center of the city.

  • How long is the flight from Charleston to South America?

    Airlines like Spirit Airlines, JetBlue, and LATAM Airlines fly from Charleston to South America in about 7h 08m. The time it takes to get you to your destination can typically vary by up to 21h 28m. Charleston and South America are separated by a distance of 1869 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines to fly from Charleston to South America one-way?

    The cheapest airlines for a one-way flight from Charleston to South America are American Airlines ($296), Delta ($356), and LATAM Airlines ($356).

  • What are the most popular routes from Charleston to South America?

    Most travelers choose Charleston - Lima J Chavez Intl, Charleston - Sao Paulo Guarulhos Intl or Charleston - Guayaquil Jose Joaquin de Olmedo when deciding on the best route from Charleston to South America.

  • Can I find deals for flights from Charleston to South America that include hotel bookings?

    Yes. In addition to deals on Charleston to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Charleston to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Charleston to South America.

  • Can I find deals for business class flights from Charleston to South America?

    Yes. Cheapflights offers flight deals from Charleston to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Charleston to South America?

    Currently, November is the cheapest month in which you can book a flight from Charleston to South America (average of $113). Flying from Charleston to South America in May is currently the most expensive (average of $546). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Charleston to South America

See prices for flight routes from nearby airports that may be better suited for you.
Charlotte to John F Kennedy Intl flights
Charlotte to Hobby flights
Charlotte to Newark flights
Charlotte to Las Vegas flights
Charlotte to George Bush Intcntl flights
Charlotte to LaGuardia flights
Charlotte to Fort Lauderdale flights
Charlotte to Miami flights
Charlotte to Denver flights
Charlotte to Orlando flights
Charlotte to O'Hare Intl flights
Charlotte to Seattle flights
Charlotte to Luis Munoz Marin Intl flights
Charlotte to Cancún flights
Charlotte to Dallas/Fort Worth flights
Charlotte to Dulles Intl flights
Charlotte to Heathrow flights
Charlotte to Sky Harbor Intl flights
Charlotte to Boston flights
Charlotte to Baltimore flights
Charlotte to Tampa flights
Charlotte to Los Angeles flights
Charlotte to Dublin flights
Charlotte to Leonardo da Vinci/Fiumicino flights
Charlotte to New Orleans flights
Charlotte to Detroit flights
Savannah to John F Kennedy Intl flights
Charleston to O'Hare Intl flights
Charleston to John F Kennedy Intl flights
Charleston to Newark flights
Charlotte to Philadelphia flights
Charlotte to Cozumel flights
Charlotte to Salt Lake City flights
Charleston to Hobby flights
Charlotte to Charles de Gaulle flights
Charlotte to San Francisco flights
Charlotte to Midway flights
Charlotte to Love Field flights
Charlotte to Narita flights
Charlotte to Madrid flights
Charleston to LaGuardia flights
Charleston to Denver flights
Columbia to LaGuardia flights
Savannah to Newark flights
Charleston to Boston flights
Charlotte to West Palm Beach flights
Charlotte to Punta Cana flights
Charlotte to San Diego flights
Charlotte to Honolulu flights
Charlotte to Haneda flights

Top 3 airlines flying from Charleston to South America

Discover the top 3 airlines that operate flights from Charleston to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$301Average$815FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$458Average$792FlexibilityNo cancel feeOn-time71%
LATAM AirlinesCheapest$542Average$732FlexibilityNo cancel feeOn-time81%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.