HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santiago

$296+ Cheap flights from South Carolina to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/7. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SCL
Jul 6 — Jul 131
Sun 7/6
Sun 7/13
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from South Carolina to Santiago with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from South Carolina to Santiago

Keep the following information in mind while searching for South Carolina to Santiago flight deals. Data was last updated July 1, 2025.

Round-trip from

$586
(Avianca Connect)

One-way from

$296
(Kiwi.com)
From South Carolina to Santiago Arturo Merino Benitez
Search Deals
One-way flight from South Carolina to Santiago Arturo Merino Benitez
Search Deals

Find flight deals from South Carolina to Santiago

Cheapest flights from South Carolina to Santiago
Explore the most affordable flight options available from South Carolina to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

This Avianca Connect deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/146:00 amCLT - SCL
2 stops22h 15mMultiple Airlines
Thu 8/212:30 pmSCL - CLT
2 stops22h 08mMultiple Airlines
Deal found 6/30$586
This Justfly.com deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/110:04 amCLT - SCL
1 stop20h 41mLATAM Airlines
Tue 10/1410:50 pmSCL - CLT
1 stop16h 02mLATAM Airlines
Deal found 7/1$746
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/227:00 amCLT - SCL
1 stop22h 00mDelta
Tue 12/28:50 pmSCL - CLT
2 stops21h 13mDelta
Deal found 7/1$754
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/229:45 amSAV - SCL
1 stop21h 20mAmerican Airlines
Wed 10/299:15 pmSCL - SAV
1 stop12h 54mAmerican Airlines
Deal found 6/30$804
This American Airlines deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/154:46 pmGSP - SCL
1 stop14h 19mAmerican Airlines
Mon 10/2710:15 pmSCL - GSP
1 stop19h 50mAmerican Airlines
Deal found 6/29$804
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/2210:20 amSAV - SCL
2 stops17h 10mDelta
Tue 10/2812:25 amSCL - SAV
2 stops21h 22mDelta
Deal found 6/30$874
This Justfly.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/112:09 pmGSP - SCL
1 stop17h 51mLATAM Airlines
Mon 10/1312:25 amSCL - GSP
2 stops19h 24mLATAM Airlines
Deal found 6/30$889
This Trip.com deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/1310:45 amMYR - SCL
2 stops19h 45mMultiple Airlines
Sat 7/1911:25 pmSCL - MYR
2 stops22h 52mMultiple Airlines
Deal found 6/30$916
This LATAM Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2312:13 pmSAV - SCL
1 stop17h 47mLATAM Airlines
Tue 10/79:40 pmSCL - SAV
1 stop14h 36mLATAM Airlines
Deal found 6/30$959
This Delta deal was found by Cheapflights users on 6/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/184:00 pmGSP - SCL
1 stop15h 00mDelta
Fri 8/228:40 pmSCL - GSP
1 stop14h 49mDelta
Deal found 6/29$1,034
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/1510:56 amCHS - SCL
1 stop19h 59mAmerican Airlines
Fri 8/229:55 pmSCL - CHS
1 stop12h 14mAmerican Airlines
Deal found 6/30$1,034
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/162:55 pmCHS - SCL
1 stop16h 05mDelta
Tue 8/198:40 pmSCL - CHS
1 stop22h 14mDelta
Deal found 6/30$1,044

Cheapflights Fare Finder

Customize your flight search to find flights from South Carolina to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
Use the filters below to find and compare flights from South Carolina to Santiago that are best for you.

Fly from

South Carolina

Fly to

Santiago

Route

Depart

Return

Price

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Thu 8/14

6:00 am-4:15 am

2 stops22h 15m

Santiago Arturo Merino Benitez

Thu 8/21

2:30 pm-12:38 pm

2 stops22h 08m

$586

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Wed 10/1

10:04 am-7:45 am

1 stop20h 41m

Santiago Arturo Merino Benitez

Tue 10/14

10:50 pm-1:52 pm

1 stop16h 02m

$746

CharlotteSantiago

CLT - SCL

CLTSCL

Charlotte Douglas

Sat 11/22

7:00 am-7:00 am

1 stop22h 00m

Santiago Arturo Merino Benitez

Tue 12/2

8:50 pm-4:03 pm

2 stops21h 13m

$754

SavannahSantiago

SAV - SCL

SAVSCL

Savannah/Hilton Head

Wed 10/22

9:45 am-8:05 am

1 stop21h 20m

Santiago Arturo Merino Benitez

Wed 10/29

9:15 pm-9:09 am

1 stop12h 54m

$804

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 10/15

4:46 pm-8:05 am

1 stop14h 19m

Santiago Arturo Merino Benitez

Mon 10/27

10:15 pm-5:05 pm

1 stop19h 50m

$804

SavannahSantiago

SAV - SCL

SAVSCL

Savannah/Hilton Head

Wed 10/22

10:20 am-4:30 am

2 stops17h 10m

Santiago Arturo Merino Benitez

Tue 10/28

12:25 am-8:47 pm

2 stops21h 22m

$874

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Wed 10/1

12:09 pm-7:00 am

1 stop17h 51m

Santiago Arturo Merino Benitez

Mon 10/13

12:25 am-6:49 pm

2 stops19h 24m

$889

Myrtle BeachSantiago

MYR - SCL

MYRSCL

Myrtle Beach Intl

Sun 7/13

10:45 am-6:30 am

2 stops19h 45m

Santiago Arturo Merino Benitez

Sat 7/19

11:25 pm-10:17 pm

2 stops22h 52m

$916

SavannahSantiago

SAV - SCL

SAVSCL

Savannah/Hilton Head

Tue 9/23

12:13 pm-7:00 am

1 stop17h 47m

Santiago Arturo Merino Benitez

Tue 10/7

9:40 pm-11:16 am

1 stop14h 36m

$959

GreenvilleSantiago

GSP - SCL

GSPSCL

Greenville

Mon 8/18

4:00 pm-7:00 am

1 stop15h 00m

Santiago Arturo Merino Benitez

Fri 8/22

8:40 pm-11:29 am

1 stop14h 49m

$1,034

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Showing 1-10 of 28 results
1
2
3

Best time to book a flight from South Carolina to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to Santiago

What is the cheapest month to book a flight from South Carolina to Santiago?

Currently, April is the cheapest month in which you can book a flight from South Carolina to Santiago (average of $752). Flying from South Carolina to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from SC to SCL?

Find hourly flight availability from South Carolina to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 1, 2025.

When flying from South Carolina to Santiago, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated July 1, 2025.
Read through reviews of airlines operating flights from South Carolina to Santiago, such as Delta, LATAM Airlines, and Qantas Airways. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,973 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,973 reviews
Delta
8.0
Very good
7,973 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
LATAM Airlines
7.5
Good
1,801 reviews
Delta
8.0
Very good
7,973 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Qantas Airways
7.5
Good
870 reviews
Delta
8.0
Very good
7,973 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Copa Airlines
7.5
Good
1,465 reviews
Delta
8.0
Very good
7,973 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,973 reviews

Entertainment

7.9

Food

7.3

Overall

8.0

Crew

8.5

Comfort

7.9

Boarding

8.2

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from South Carolina to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santiago from South Carolina?

    For a flight from South Carolina to Santiago, you will be flying into Arturo Merino Benitez. Santiago Arturo Merino Benitez (SCL) is just 8.4 mi from the center of the city.

  • What are the cheapest airlines to fly from South Carolina to Santiago one-way?

    The cheapest airlines for a one-way flight from South Carolina to Santiago are LATAM Airlines ($512), Delta ($518), and American Airlines ($527).

  • What are the most popular routes from South Carolina to Santiago?

    The most popular flight routes from South Carolina to Santiago are Charlotte Douglas - Santiago Arturo Merino Benitez, Greenville - Santiago Arturo Merino Benitez and Charleston - Santiago Arturo Merino Benitez.

  • Can I find deals for flights from South Carolina to Santiago that include hotel bookings?

    Yes. In addition to deals on South Carolina to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to Santiago.

  • Can I find deals for business class flights from South Carolina to Santiago?

    Yes. Cheapflights offers flight deals from South Carolina to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to Santiago?

    Currently, April is the cheapest month in which you can book a flight from South Carolina to Santiago (average of $752). Flying from South Carolina to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for South Carolina to Santiago

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Santiago flights
Miami to Santiago flights
Los Angeles to Santiago flights
LaGuardia to Santiago flights
Newark to Santiago flights
Dulles Intl to Santiago flights
San Francisco to Santiago flights
Reagan-National to Santiago flights
Dallas/Fort Worth to Santiago flights
Baltimore to Santiago flights
Atlanta to Santiago flights
O'Hare Intl to Santiago flights
Boston to Santiago flights
Fort Lauderdale to Santiago flights
Midway to Santiago flights
Denver to Santiago flights
Hobby to Santiago flights
Seattle to Santiago flights
San Diego to Santiago flights
Sky Harbor Intl to Santiago flights
Orlando to Santiago flights
Ontario to Santiago flights
George Bush Intcntl to Santiago flights
Tampa to Santiago flights
Minneapolis to Santiago flights
Love Field to Santiago flights
Portland to Santiago flights
Austin to Santiago flights
Detroit to Santiago flights
Boston to Punta Arenas flights
Salt Lake City to Santiago flights
Tucson to Santiago flights
Las Vegas to Santiago flights
Charlotte to Santiago flights
Memphis to Santiago flights
John F Kennedy Intl to Punta Arenas flights
Philadelphia to Santiago flights
Raleigh to Santiago flights
Boise to Santiago flights
John F Kennedy Intl to Easter Island flights
Indianapolis to Santiago flights
Knoxville to Santiago flights
Cincinnati to Santiago flights
Hartford to Santiago flights
St. Louis to Santiago flights
Nashville to Santiago flights
Grand Rapids to Santiago flights
O'Hare Intl to Easter Island flights

Top 2 airlines flying from South Carolina to Santiago

Discover the top 2 airlines that operate flights from South Carolina to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$532Average$920FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$603Average$890FlexibilityNo cancel feeOn-time81%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.