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$64+ Cheap flights from Des Moines to Santa Ana (DSM - SNA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/2. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SNA
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheapflights Tip: The best prices from Des Moines to Santa Ana J. Wayne/Orange Cnty are usually found in September or April, booked 77 days in advance, depart on a Sunday or Thursday and return on a Wednesday

Cheap flight deals from Des Moines to Santa Ana

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$149
(Cheapflightsfares)

One-way from

$64
(Cheapflightsfares)

Popular in

November

Cheapest in

September

Average price

$131

Good round-trip deal

$105 or less

Good one-way deal

$77 or less
From Des Moines to Santa Ana J. Wayne/Orange Cnty
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One-way flight from Des Moines to Santa Ana J. Wayne/Orange Cnty
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Highest demand for flights based on searches. 12% potential increase in price ($47 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Price to beat on a round-trip flight from Des Moines to Santa Ana J. Wayne/Orange Cnty.
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Price to beat on a one-way flight from Des Moines to Santa Ana J. Wayne/Orange Cnty.
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Find flight deals from Des Moines to Santa Ana

Cheapest flights from Des Moines to Santa Ana
Explore the most affordable flight options available from Des Moines to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/258:00 amDSM - SNA
Nonstop3h 43mAllegiant Air
Sun 9/2810:33 amSNA - DSM
Nonstop3h 15mAllegiant Air
Deal found 9/13$149
This Cheapflightsfares deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/268:00 amDSM - SNA
Nonstop3h 35mAllegiant Air
Thu 10/3011:25 amSNA - DSM
Nonstop3h 19mAllegiant Air
Deal found 9/14$150
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/29:00 amDSM - SNA
Nonstop3h 35mMultiple Airlines
Wed 11/52:20 pmSNA - DSM
1 stop21h 27mMultiple Airlines
Deal found 9/13$160
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/102:32 pmDSM - SNA
1 stop25h 03mFrontier
Sat 11/152:20 pmSNA - DSM
1 stop21h 27mFrontier
Deal found 9/13$172
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/102:32 pmDSM - SNA
1 stop25h 03mMultiple Airlines
Thu 11/1311:37 amSNA - DSM
Nonstop3h 22mMultiple Airlines
Deal found 9/13$175
This eDestinos deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/309:00 amDSM - SNA
Nonstop3h 35mAllegiant Air
Thu 11/611:37 amSNA - DSM
Nonstop3h 22mAllegiant Air
Deal found 9/15$195
This Kiwi.com deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/102:32 pmDSM - SNA
1 stop25h 03mFrontier
Thu 11/1312:01 pmSNA - DSM
1 stop23h 48mFrontier
Deal found 9/14$199
This Kiwi.com deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/102:32 pmDSM - SNA
1 stop25h 03mMultiple Airlines
Sat 11/155:46 pmSNA - DSM
2 stops18h 01mMultiple Airlines
Deal found 9/13$204

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Des Moines to Santa Ana that are best for you.

Fly from

Des Moines

Fly to

Santa Ana

Route

Depart

Return

Price

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 11/10

2:32 pm-1:35 pm

1 stop25h 03m

Santa Ana J. Wayne/Orange Cnty

Thu 11/13

12:01 pm-1:49 pm

1 stop23h 48m

$199

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 11/13

2:32 pm-11:16 am

1 stop22h 44m

Santa Ana J. Wayne/Orange Cnty

Sat 11/15

2:20 pm-1:47 pm

1 stop21h 27m

$229

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 11/10

2:32 pm-1:35 pm

1 stop25h 03m

Santa Ana J. Wayne/Orange Cnty

Fri 11/14

4:49 pm-4:38 pm

2 stops21h 49m

$254

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sat 11/15

3:30 pm-8:14 pm

1 stop6h 44m

Santa Ana J. Wayne/Orange Cnty

Tue 11/18

12:46 pm-10:33 pm

1 stop7h 47m

$261

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sat 11/1

12:55 pm-6:05 pm

1 stop7h 10m

Santa Ana J. Wayne/Orange Cnty

Wed 11/5

12:45 pm-7:55 pm

1 stop5h 10m

$261

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sat 11/15

3:30 pm-8:14 pm

1 stop6h 44m

Santa Ana J. Wayne/Orange Cnty

Wed 11/19

11:46 am-8:47 pm

1 stop7h 01m

$261

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sat 11/1

12:55 pm-6:05 pm

1 stop7h 10m

Santa Ana J. Wayne/Orange Cnty

Tue 11/4

12:45 pm-7:55 pm

1 stop5h 10m

$261

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Wed 11/12

9:30 am-8:58 am

1 stop25h 28m

Santa Ana J. Wayne/Orange Cnty

Sat 11/15

2:20 pm-1:47 pm

1 stop21h 27m

$266

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 10/30

9:00 am-10:35 am

Nonstop3h 35m

Santa Ana J. Wayne/Orange Cnty

Thu 11/6

7:15 am-8:13 pm

2 stops10h 58m

$269

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sat 11/15

10:00 am-8:58 am

1 stop24h 58m

Santa Ana J. Wayne/Orange Cnty

Wed 11/19

5:46 pm-3:27 pm

1 stop19h 41m

$279

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 19 results
1
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Best time to book a flight from Des Moines to Santa Ana

Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Santa Ana

How far ahead should I book a flight from Des Moines to Santa Ana?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Santa Ana. Price data was last updated on September 12, 2025.

To ensure you get the cheapest price possible for a flight from Des Moines to Santa Ana, you should look to book at least 76 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Des Moines to Santa Ana?

Currently, January is the cheapest month in which you can book a flight from Des Moines to Santa Ana (average of $298). Flying from Des Moines to Santa Ana in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SNA?

Find hourly flight availability from Des Moines to Santa Ana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

A simple way to save on the total cost of your ticket is to fly from Des Moines to Santa Ana at noon. If you’re flexible enough to do this you can expect to save up to 39% on your trip compared to booking a flight in the morning.

Reviews of airlines servicing Santa Ana

Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated September 15, 2025.
Read through reviews of airlines operating flights from Des Moines to Santa Ana, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Comfort

8.0

Overall

8.0

Entertainment

7.5

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,242 reviews
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Comfort

8.0

Overall

8.0

Entertainment

7.5

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Delta
8.0
Very good
7,954 reviews
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Comfort

8.0

Overall

8.0

Entertainment

7.5

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
8,929 reviews
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Comfort

8.0

Overall

8.0

Entertainment

7.5

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
10,000 reviews
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Comfort

8.0

Overall

8.0

Entertainment

7.5

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Allegiant Air
7.2
Good
699 reviews
Southwest
8.0
Very good
4,242 reviews

Crew

8.6

Comfort

8.0

Overall

8.0

Entertainment

7.5

Boarding

8.1

Food

7.0

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Des Moines to Santa Ana flight route?

    This flight path from Des Moines to Santa Ana J. Wayne/Orange Cnty was viewed by 8 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Des Moines to Santa Ana?

    A quick flight from Des Moines to Santa Ana can take about 6h 44m. Frontier provides one of the quickest options available for as low as $261. Des Moines and Santa Ana are separated by a distance of 1425 mi. This flight may include one or multiple stops.

  • What are the cheapest airlines flying from Des Moines to Santa Ana round-trip?

    According to our current data, Allegiant Air ($108), Delta ($130), and American Airlines ($286) offers the cheapest pricing from Des Moines to Santa Ana. Allegiant Air is currently priced 66% below the average price you’ll pay for this route.

  • What are the cheapest flights from Des Moines to Santa Ana?

    On average you can expect to pay $118 for a flight from Des Moines to Santa Ana. The cheapest flight overall is $64 while the most popular route, (Des Moines - Santa Ana J. Wayne/Orange Cnty) is currently priced at $150.

  • Can I find deals for flights from Des Moines to Santa Ana that include hotel bookings?

    Yes. In addition to deals on Des Moines to Santa Ana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Santa Ana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santa Ana.

  • Can I find deals for business class flights from Des Moines to Santa Ana?

    Yes. Cheapflights offers flight deals from Des Moines to Santa Ana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Santa Ana?

    Currently, January is the cheapest month in which you can book a flight from Des Moines to Santa Ana (average of $298). Flying from Des Moines to Santa Ana in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Ana?

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Top 5 airlines flying from Des Moines to Santa Ana

Discover the top 5 airlines that operate flights from Des Moines to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$108Average$222FlexibilityNo cancel feeOn-time88%
DeltaCheapest$130Average$326FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$286Average$406FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$298Average$471FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$382Average$506FlexibilityNo cancel feeOn-time63%

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