HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santa Ana

$39+ Cheap flights from Des Moines to Santa Ana, CA (DSM - SNA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SNA
Jan 3 — Jan 101
Sat 1/3
Sat 1/10
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Des Moines to Santa Ana with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Des Moines to Santa Ana J. Wayne/Orange Cnty are usually found in September or October, booked 76 days in advance, depart on a Sunday or Friday and return on a Thursday

Cheap flight deals from Des Moines to Santa Ana

Cheapest flights from Des Moines to Santa Ana
Explore the most affordable flight options available from Des Moines to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 4, 2025.

This Kiwi.com deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/77:00 amDSM - SNA
Nonstop3h 46mAllegiant Air
Thu 12/119:36 amSNA - DSM
Nonstop3h 18mAllegiant Air
Deal found 12/4$248
This Cheapflightsfares deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/217:00 amDSM - SNA
Nonstop3h 46mAllegiant Air
Sun 1/259:37 amSNA - DSM
Nonstop3h 26mAllegiant Air
Deal found 12/4$282
This Kiwi.com deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/77:00 amDSM - SNA
Nonstop3h 46mMultiple Airlines
Thu 12/116:34 pmSNA - DSM
1 stop22h 04mMultiple Airlines
Deal found 12/4$290
This Cheapflightsfares deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/187:00 amDSM - SNA
Nonstop3h 46mAllegiant Air
Sun 1/189:37 amSNA - DSM
Nonstop3h 26mAllegiant Air
Deal found 12/3$294
This Mytrip deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/197:54 pmDSM - SNA
1 stop16h 22mMultiple Airlines
Thu 1/86:45 amSNA - DSM
1 stop6h 55mMultiple Airlines
Deal found 12/4$295
This Mytrip deal was found by Cheapflights users on 12/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/218:30 amDSM - SNA
1 stop15h 57mMultiple Airlines
Sun 1/259:37 amSNA - DSM
Nonstop3h 26mMultiple Airlines
Deal found 12/4$298
This Mytrip deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/188:30 amDSM - SNA
1 stop15h 57mMultiple Airlines
Sun 1/189:37 amSNA - DSM
Nonstop3h 26mMultiple Airlines
Deal found 12/3$324
This Trip.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/187:00 amDSM - SNA
Nonstop3h 46mMultiple Airlines
Mon 12/2211:53 amSNA - DSM
1 stop5h 51mMultiple Airlines
Deal found 12/3$343
This Kiwi.com deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/187:00 amDSM - SNA
Nonstop3h 46mMultiple Airlines
Sun 12/217:57 pmSNA - DSM
1 stop21h 07mMultiple Airlines
Deal found 12/3$350

Find flight deals from Des Moines to Santa Ana

Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 4, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$78
(Kiwi.com)

One-way from

$39
(Mytrip)

Popular in

November

Cheapest in

September

Average price

$381

Good round-trip deal

$127 or less
Provider with most accurate pricing for Des Moines-Santa Ana J. Wayne/Orange Cnty flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Santa Ana J. Wayne/Orange Cnty flights.
Search Deals
From Des Moines to Santa Ana J. Wayne/Orange Cnty
Search Deals
One-way flight from Des Moines to Santa Ana J. Wayne/Orange Cnty
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($39 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals
Price to beat on a round-trip flight from Des Moines to Santa Ana J. Wayne/Orange Cnty.
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from Des Moines to Santa Ana that are best for you.

Fly from

Des Moines

Fly to

Santa Ana

Route

Depart

Return

Price

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 1/22

7:00 am-8:47 am

Nonstop3h 47m

Santa Ana J. Wayne/Orange Cnty

Sun 1/25

9:37 am-3:03 pm

Nonstop3h 26m

$190

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 1/22

6:17 pm-9:49 pm

1 stop5h 32m

Santa Ana J. Wayne/Orange Cnty

Thu 1/29

4:23 pm-11:58 pm

1 stop5h 35m

$197

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 1/22

5:30 am-12:15 pm

2 stops8h 45m

Santa Ana J. Wayne/Orange Cnty

Thu 1/29

11:05 am-8:34 pm

1 stop7h 29m

$222

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sat 2/21

2:24 pm-7:03 pm

1 stop6h 39m

Santa Ana J. Wayne/Orange Cnty

Wed 2/25

6:45 am-1:43 pm

1 stop4h 58m

$231

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sat 2/21

6:15 pm-10:25 pm

1 stop6h 10m

Santa Ana J. Wayne/Orange Cnty

Wed 2/25

8:55 am-7:20 pm

2 stops8h 25m

$241

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Fri 1/23

2:08 pm-2:37 pm

3 stops26h 29m

Santa Ana J. Wayne/Orange Cnty

Sun 1/25

9:37 am-3:03 pm

Nonstop3h 26m

$267

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Fri 12/19

7:54 pm-10:16 am

1 stop16h 22m

Santa Ana J. Wayne/Orange Cnty

Thu 1/8

6:45 am-3:40 pm

1 stop6h 55m

$295

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 1/22

2:58 pm-6:46 pm

3 stops29h 48m

Santa Ana J. Wayne/Orange Cnty

Sun 1/25

9:37 am-3:03 pm

Nonstop3h 26m

$297

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sun 12/21

8:30 am-10:27 pm

1 stop15h 57m

Santa Ana J. Wayne/Orange Cnty

Sun 1/25

9:37 am-3:03 pm

Nonstop3h 26m

$298

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sun 1/18

3:35 pm-10:24 pm

1 stop8h 49m

Santa Ana J. Wayne/Orange Cnty

Thu 1/22

10:51 am-9:50 pm

1 stop8h 59m

$319

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/2

Showing 1-10 of 19 results
1
2

Compare providers for flights from Des Moines to Santa Ana

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santa Ana in December.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy2 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Des Moines-Santa Ana, California flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Des Moines-Santa Ana, California flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Des Moines-Santa Ana, California flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Des Moines-Santa Ana, California flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santa Ana, California flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Santa Ana

Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Santa Ana

How far ahead should I book a flight from Des Moines to Santa Ana, California?

Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Santa Ana. Price data was last updated on November 28, 2025.

To ensure you get the cheapest price possible for a flight from Des Moines to Santa Ana, California, you should look to book at least 69 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Des Moines to Santa Ana, California?

Currently, May is the cheapest month in which you can book a flight from Des Moines to Santa Ana, California (average of $101). Flying from Des Moines to Santa Ana, California in July is currently the most expensive (average of $236). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SNA?

Find hourly flight availability from Des Moines to Santa Ana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 4, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Santa Ana, California as you normally would.

Reviews of airlines servicing Santa Ana

Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated December 4, 2025.
Read through reviews of airlines operating flights from Des Moines to Santa Ana, such as Southwest, United Airlines, and American Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Southwest
8.0
Very good
4,254 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Southwest
8.0
Very good
4,254 reviews
Southwest
8.0
Very good
4,254 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
United Airlines
7.4
Good
9,066 reviews
Southwest
8.0
Very good
4,254 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
American Airlines
7.2
Good
11,046 reviews
Southwest
8.0
Very good
4,254 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.
Allegiant Air
7.2
Good
698 reviews
Southwest
8.0
Very good
4,254 reviews

Food

7.0

Comfort

8.0

Entertainment

7.5

Overall

8.0

Boarding

8.1

Crew

8.6

Reviews

1 / 20
8.0
Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Des Moines to Santa Ana, California flight route?

    The Des Moines to Santa Ana J. Wayne/Orange Cnty flight path was viewed by 3 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Des Moines to Santa Ana, California?

    There are many flights that can get you from Des Moines to Santa Ana, California in 3h 47m. Fly via Allegiant Air or Southwest to get the fastest option. Des Moines and Santa Ana, California are separated by a distance of 1425 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines flying from Des Moines to Santa Ana, California round-trip?

    Our cheapest airline available from Des Moines to Santa Ana, California is Allegiant Air. Our recent data shows that you can find tickets from as low as $108 on this airline. Additional options worth looking into are United Airlines and American Airlines, starting at $213 and $286 round-trip. Allegiant Air is 66% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the cheapest airlines to fly from Des Moines to Santa Ana, California one-way?

    To fly one-way, consider booking your trip with Allegiant Air, which is currently one of the cheapest options available, starting at $64. American Airlines flights start at $130 while deals on Southwest start at $143 one-way.

  • What are the cheapest flights from Des Moines to Santa Ana, California?

    On average you can expect to pay $142 for a flight from Des Moines to Santa Ana, California. The cheapest flight overall is $117 while the most popular route, (Des Moines - Santa Ana J. Wayne/Orange Cnty) is currently priced at $127.

  • Can I find deals for flights from Des Moines to Santa Ana that include hotel bookings?

    Yes. In addition to deals on Des Moines to Santa Ana flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Santa Ana?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santa Ana.

  • Can I find deals for business class flights from Des Moines to Santa Ana?

    Yes. Cheapflights offers flight deals from Des Moines to Santa Ana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Des Moines to Santa Ana, California?

    Currently, May is the cheapest month in which you can book a flight from Des Moines to Santa Ana, California (average of $101). Flying from Des Moines to Santa Ana, California in July is currently the most expensive (average of $236). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Ana?

Book flights to Santa Ana if you plan to visit one of these locations
Tustin

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Santa Ana

See prices for flight routes from nearby airports that may be better suited for you.
Omaha to Las Vegas flights
Des Moines to Las Vegas flights
Omaha to Los Angeles flights
Cedar Rapids to Las Vegas flights
Des Moines to Los Angeles flights
Omaha to San Francisco flights
Omaha to San Diego flights
Des Moines to San Diego flights
Des Moines to San Francisco flights
Cedar Rapids to San Diego flights
Moline to Las Vegas flights
Moline to Los Angeles flights
Cedar Rapids to Los Angeles flights
Cedar Rapids to San Francisco flights
Des Moines to Palm Springs flights
Cedar Rapids to Santa Ana flights
Omaha to Ontario flights
Omaha to Palm Springs flights
Des Moines to Ontario flights
Cedar Rapids to Ontario flights
Omaha to Santa Ana flights
Cedar Rapids to Palm Springs flights
Omaha to San Jose flights
Omaha to Reno flights
Cedar Rapids to San Jose flights
Des Moines to San Jose flights
Omaha to Sacramento flights
Omaha to Oakland flights
Cedar Rapids to Reno flights
Des Moines to Reno flights
Moline to Palm Springs flights
Moline to San Diego flights
Moline to Ontario flights
Cedar Rapids to Sacramento flights
Des Moines to Sacramento flights
Des Moines to Burbank flights
Des Moines to Santa Barbara flights
Moline to Santa Ana flights
Omaha to Burbank flights
Moline to San Francisco flights
Des Moines to San Luis Obispo flights
Cedar Rapids to Burbank flights
Sioux City to Las Vegas flights
La Crosse to Las Vegas flights
Omaha to Long Beach flights
Cedar Rapids to Long Beach flights
Moline to Burbank flights
Omaha to Santa Barbara flights
Cedar Rapids to Fresno flights

Top 4 airlines flying from Des Moines to Santa Ana

Discover the top 4 airlines that operate flights from Des Moines to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$108Average$195FlexibilityNo cancel feeOn-time88%
United AirlinesCheapest$260Average$442FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$286Average$406FlexibilityNo cancel feeOn-time71%
SouthwestCheapest$340Average$476FlexibilityNo cancel feeOn-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.