How popular is this Des Moines to Santa Ana, California flight route?

The Des Moines to Santa Ana J. Wayne/Orange Cnty flight path was viewed by 8 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

How long is the flight from Des Moines to Santa Ana, California?

There are many flights that can get you from Des Moines to Santa Ana, California in 3h 35m. Fly via Allegiant Air, Frontier, or Delta to get the fastest option. Des Moines and Santa Ana, California are separated by a distance of 1425 mi. Both multi-stop and nonstop flights can be found to your destination and back.

What are the cheapest airlines flying from Des Moines to Santa Ana, California round-trip?

Our cheapest airline available from Des Moines to Santa Ana, California is Allegiant Air. Our recent data shows that you can find tickets from as low as $108 on this airline. Additional options worth looking into are Delta and United Airlines, starting at $130 and $260 round-trip. Allegiant Air is 65% cheaper than the average price of flights available within the next 90 days to this destination.

What are the cheapest airlines to fly from Des Moines to Santa Ana, California one-way?

To fly one-way, consider booking your trip with Allegiant Air, which is currently one of the cheapest options available, starting at $92. Frontier flights start at $97 while deals on United Airlines start at $177 one-way.

In terms of precipitation, rainfall in Santa Ana, California ranges from 0.0 - 3.1 inches per month. February is typically the wettest month, when rainfall can reach 3.1 in. July is typically the driest time to visit Santa Ana, California when rainfall is around 0.0 in.

If weather is an important factor for your trip to Santa Ana, California, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 55.4 F).

What are the cheapest flights from Des Moines to Santa Ana, California?

On average you can expect to pay $187 for a flight from Des Moines to Santa Ana, California. The cheapest flight overall is $91 while the most popular route, (Des Moines - Santa Ana J. Wayne/Orange Cnty) is currently priced at $160.

What are the most popular airlines that fly from Des Moines to Santa Ana, California?

The most popular airlines flying from Des Moines to Santa Ana, California are Allegiant Air, American Airlines and United Airlines. Something to consider prior to booking your flight.

Most accurate provider : When it comes to deals on Des Moines-Santa Ana, California flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santa Ana, California flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santa Ana, California flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Des Moines-Santa Ana, California flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santa Ana, California flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Des Moines to Santa Ana that include hotel bookings?

Yes. In addition to deals on Des Moines to Santa Ana flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Des Moines to Santa Ana?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santa Ana.

Can I find deals for business class flights from Des Moines to Santa Ana?

Yes. Cheapflights offers flight deals from Des Moines to Santa Ana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$84+ Cheap Flights from Des Moines to Santa Ana, CA

Home Search by date Vacation packages Hotels Flight deals Car rental Travel tips & news

Find cheap flights from Des Moines to Santa Ana with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Des Moines to Santa Ana J. Wayne/Orange Cnty are usually found in September or April, booked 77 days in advance, depart on a Sunday or Thursday and return on a Wednesday

Cheap flight deals from Des Moines to Santa Ana

Most accurate provider	FlightHub 3 stars
Most trusted provider	FlightHub 3 stars
Round-trip from	$151 (FlightHub)
One-way from	$84 (Cheapflightsfares)
Popular in	March
Cheapest in	September
Average price	$244
Good round-trip deal	$227 or less
Good one-way deal	$112 or less

Provider with most accurate pricing for Des Moines-Santa Ana J. Wayne/Orange Cnty flight deals.

Search Deals

Provider most trusted by Cheapflights users for Des Moines-Santa Ana J. Wayne/Orange Cnty flights.

Search Deals

From Des Moines to Santa Ana J. Wayne/Orange Cnty

Search Deals

One-way flight from Des Moines to Santa Ana J. Wayne/Orange Cnty

Search Deals

Highest demand for flights based on searches. 3% potential increase in price ($10 potential increase over avg. RT price).

Search Deals

Cheapest flight prices on average. 2% potential price decrease ($9 potential savings vs. average RT price).

Search Deals

Average for round-trip flights in October 2025

Search Deals

Price to beat on a round-trip flight from Des Moines to Santa Ana J. Wayne/Orange Cnty.

Search Deals

Price to beat on a one-way flight from Des Moines to Santa Ana J. Wayne/Orange Cnty.

Search Deals

Find flight deals from Des Moines to Santa Ana

Cheapest flights from Des Moines to Santa Ana
Explore the most affordable flight options available from Des Moines to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2025.

Sun 11/99:00 amDSM - SNA

Nonstop3h 47mMultiple Airlines

Wed 11/123:01 pmSNA - DSM

1 stop20h 55mMultiple Airlines

Deal found 10/12

$151

Thu 10/309:00 amDSM - SNA

Nonstop3h 35mAllegiant Air

Thu 11/1311:37 amSNA - DSM

Nonstop3h 22mAllegiant Air

Deal found 10/12

$159

Thu 10/302:32 pmDSM - SNA

1 stop22h 44mMultiple Airlines

Sun 11/211:25 amSNA - DSM

Nonstop3h 19mMultiple Airlines

Deal found 10/13

$160

Mon 11/102:32 pmDSM - SNA

1 stop24h 58mMultiple Airlines

Thu 11/1311:37 amSNA - DSM

Nonstop3h 22mMultiple Airlines

Deal found 10/12

$166

Mon 11/102:32 pmDSM - SNA

1 stop24h 58mFrontier

Thu 11/1312:01 pmSNA - DSM

1 stop23h 48mFrontier

Deal found 10/12

$180

Thu 10/309:00 amDSM - SNA

Nonstop3h 35mAllegiant Air

Sun 11/211:25 amSNA - DSM

Nonstop3h 19mAllegiant Air

Deal found 10/13

$200

Mon 12/158:15 pmDSM - SNA

1 stop17h 25mMultiple Airlines

Thu 12/189:36 amSNA - DSM

Nonstop3h 18mMultiple Airlines

Deal found 10/12

$204

Mon 11/102:32 pmDSM - SNA

1 stop24h 58mMultiple Airlines

Fri 11/146:45 amSNA - DSM

1 stop13h 55mMultiple Airlines

Deal found 10/12

$213

Mon 11/102:32 pmDSM - SNA

1 stop24h 58mMultiple Airlines

Wed 11/191:31 pmSNA - DSM

1 stop23h 56mMultiple Airlines

Deal found 10/12

$216

Best flights from Des Moines to Santa Ana
Discover carefully curated flight deals from Des Moines to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 14, 2025.

Thu 10/302:32 pmDSM - SNA

1 stop22h 44mMultiple Airlines

Sun 11/211:25 amSNA - DSM

Nonstop3h 19mMultiple Airlines

Deal found 10/13

$160

Thu 10/309:00 amDSM - SNA

Nonstop3h 35mAllegiant Air

Sun 11/211:25 amSNA - DSM

Nonstop3h 19mAllegiant Air

Deal found 10/13

$200

Thu 10/302:32 pmDSM - SNA

1 stop22h 44mFrontier

Sun 11/212:01 pmSNA - DSM

1 stop23h 46mFrontier

Deal found 10/13

$236

Sat 11/155:35 amDSM - SNA

1 stop8h 00mDelta

Tue 11/1811:45 amSNA - DSM

1 stop7h 02mDelta

Deal found 10/12

$261

Sat 12/63:49 pmDSM - SNA

1 stop9h 10mAmerican Airlines

Sat 12/137:35 amSNA - DSM

1 stop8h 22mAmerican Airlines

Deal found 10/13

$261

Mon 12/158:15 pmDSM - SNA

2 stops27h 54mMultiple Airlines

Thu 12/189:36 amSNA - DSM

Nonstop3h 18mMultiple Airlines

Deal found 10/12

$233

Tue 12/911:29 amDSM - SNA

2 stops8h 49mAmerican Airlines

Sat 12/1312:28 pmSNA - DSM

2 stops8h 31mAmerican Airlines

Deal found 10/13

$271

Sat 11/153:30 pmDSM - SNA

1 stop6h 44mDelta

Mon 11/171:15 pmSNA - DSM

1 stop6h 00mDelta

Deal found 10/12

$301

Fri 10/313:30 pmDSM - SNA

1 stop6h 38mDelta

Tue 11/412:26 pmSNA - DSM

1 stop8h 04mDelta

Deal found 10/13

$302

Thu 1/83:59 pmDSM - SNA

1 stop6h 56mAmerican Airlines

Sat 1/106:45 amSNA - DSM

2 stops8h 21mAmerican Airlines

Deal found 10/14

$306

Last-minute flights from Des Moines to Santa Ana
Discover last-minute flight deals from Des Moines to Santa Ana. Data last updated October 14, 2025 and is based on user searches.

Sun 10/198:00 amDSM - SNA

Nonstop3h 35mMultiple Airlines

Wed 10/226:45 amSNA - DSM

1 stop6h 12mMultiple Airlines

Deal found 10/13

$244

Sun 10/263:43 pmDSM - SNA

1 stop29h 25mMultiple Airlines

Sun 11/211:25 amSNA - DSM

Nonstop3h 19mMultiple Airlines

Deal found 10/14

$266

Thu 10/302:32 pmDSM - SNA

1 stop22h 44mMultiple Airlines

Sun 11/211:25 amSNA - DSM

Nonstop3h 19mMultiple Airlines

Deal found 10/13

$160

Thu 10/309:00 amDSM - SNA

Nonstop3h 35mAllegiant Air

Sun 11/211:25 amSNA - DSM

Nonstop3h 19mAllegiant Air

Deal found 10/13

$200

Thu 10/302:32 pmDSM - SNA

1 stop22h 44mFrontier

Sun 11/212:01 pmSNA - DSM

1 stop23h 46mFrontier

Deal found 10/13

$236

Thu 11/69:00 amDSM - SNA

Nonstop3h 47mMultiple Airlines

Tue 11/111:31 pmSNA - DSM

3 stops42h 29mMultiple Airlines

Deal found 10/13

$265

Thu 11/132:16 pmDSM - SNA

1 stop8h 27mAmerican Airlines

Tue 11/181:33 pmSNA - DSM

1 stop6h 35mAmerican Airlines

Deal found 10/14

$301

One-way flights from Des Moines to Santa Ana
Search for one-way flight options from Des Moines to Santa Ana. Find affordable one-way fares based on user searches. Data last updated October 14, 2025.

Sun 11/99:00 amDSM - SNA

Nonstop3h 47mAllegiant Air

Deal found 10/12

$84

Fri 3/67:00 amDSM - SNA

Nonstop3h 55mAllegiant Air

Deal found 10/13

$92

Fri 10/243:40 pmDSM - SNA

1 stop5h 34mMultiple Airlines

Deal found 10/12

$119

Fri 1/27:00 amDSM - SNA

Nonstop3h 46mAllegiant Air

Deal found 10/13

$128

Tue 12/308:33 pmDSM - SNA

1 stop17h 07mFrontier

Deal found 10/13

$192

Tue 12/306:35 amDSM - SNA

2 stops8h 55mSouthwest

Deal found 10/13

$198

Thu 2/125:12 amDSM - SNA

1 stop6h 25mAmerican Airlines

Deal found 10/13

$212

Wed 3/115:21 amDSM - SNA

1 stop6h 11mAmerican Airlines

Deal found 10/12

$214

Wed 3/115:40 amDSM - SNA

2 stops8h 38mUnited Airlines

Deal found 10/12

$219

Fri 1/212:20 pmDSM - SNA

1 stop7h 54mMultiple Airlines

Deal found 10/13

$226

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Santa Ana that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 10/30

2:32 pm-11:16 am

1 stop22h 44m

Santa Ana J. Wayne/Orange Cnty

Sun 11/2

11:25 am-4:44 pm

Nonstop3h 19m

$160

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 10/30

9:00 am-10:35 am

Nonstop3h 35m

Santa Ana J. Wayne/Orange Cnty

Sun 11/2

11:25 am-4:44 pm

Nonstop3h 19m

$200

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Mon 12/15

8:15 pm-10:09 pm

2 stops27h 54m

Santa Ana J. Wayne/Orange Cnty

Thu 12/18

9:36 am-2:54 pm

Nonstop3h 18m

$233

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 10/30

2:32 pm-11:16 am

1 stop22h 44m

Santa Ana J. Wayne/Orange Cnty

Sun 11/2

12:01 pm-1:47 pm

1 stop23h 46m

$236

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sat 11/15

5:35 am-11:35 am

1 stop8h 00m

Santa Ana J. Wayne/Orange Cnty

Tue 11/18

11:45 am-8:47 pm

1 stop7h 02m

$261

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sat 12/6

3:49 pm-10:59 pm

1 stop9h 10m

Santa Ana J. Wayne/Orange Cnty

Sat 12/13

7:35 am-5:57 pm

1 stop8h 22m

$261

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Tue 12/9

11:29 am-6:18 pm

2 stops8h 49m

Santa Ana J. Wayne/Orange Cnty

Sat 12/13

12:28 pm-10:59 pm

2 stops8h 31m

$271

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Sat 11/15

3:30 pm-8:14 pm

1 stop6h 44m

Santa Ana J. Wayne/Orange Cnty

Mon 11/17

1:15 pm-9:15 pm

1 stop6h 00m

$301

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Fri 10/31

3:30 pm-8:08 pm

1 stop6h 38m

Santa Ana J. Wayne/Orange Cnty

Tue 11/4

12:26 pm-10:30 pm

1 stop8h 04m

$302

Des MoinesSanta Ana

DSM - SNA

DSMSNA

Des Moines

Thu 1/8

3:59 pm-8:55 pm

1 stop6h 56m

Santa Ana J. Wayne/Orange Cnty

Sat 1/10

6:45 am-5:06 pm

2 stops8h 21m

$306

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/13

Showing 1-10 of 21 results

Compare providers for flights from Des Moines to Santa Ana

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santa Ana in October.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*3 stars
eDreams	Price Accuracy3 stars	Trust Score*3 stars
Cheapflightsfares	Price Accuracy2 stars	Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Des Moines-Santa Ana, California flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santa Ana, California flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santa Ana, California flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Des Moines-Santa Ana, California flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santa Ana, California flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Des Moines to Santa Ana

Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Des Moines with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Santa Ana

How far ahead should I book a flight from Des Moines to Santa Ana, California?

To ensure you get the cheapest price possible for a flight from Des Moines to Santa Ana, California, you should look to book at least 76 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

What is the cheapest month to book a flight from Des Moines to Santa Ana, California?

Currently, May is the cheapest month in which you can book a flight from Des Moines to Santa Ana, California (average of $101). Flying from Des Moines to Santa Ana, California in July is currently the most expensive (average of $235). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from DSM to SNA?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Santa Ana, California as you normally would.

Reviews of airlines servicing Santa Ana

Read through reviews of airlines operating flights from Des Moines to Santa Ana, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Dozens of flights and I've never seen a row's beverages forgotten. I even went back and asked the attendant to check on them and nothing. I really hope it didn't have something to do with the Black mother with her kid in the row. Otherwise it was a typical Southwest flight, rapid boarding, tolerable leg room.

Southwest

8.0

Very good

4,238 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Delta

8.0

Very good

7,975 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

United Airlines

7.4

Good

8,976 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

American Airlines

7.2

Good

11,042 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Allegiant Air

7.2

Good

693 reviews

Southwest

8.0

Very good

4,238 reviews

Reviews

1 / 20

8.0

Excellent

Walter,Aug 2025

OAK - SAN

Related info for your journey

How popular is this Des Moines to Santa Ana, California flight route?
The Des Moines to Santa Ana J. Wayne/Orange Cnty flight path was viewed by 8 users in the past month. Keep an eye out for changes in search interest prior to high and low season.
How long is the flight from Des Moines to Santa Ana, California?
There are many flights that can get you from Des Moines to Santa Ana, California in 3h 35m. Fly via Allegiant Air, Frontier, or Delta to get the fastest option. Des Moines and Santa Ana, California are separated by a distance of 1425 mi. Both multi-stop and nonstop flights can be found to your destination and back.
What are the cheapest airlines flying from Des Moines to Santa Ana, California round-trip?
Our cheapest airline available from Des Moines to Santa Ana, California is Allegiant Air. Our recent data shows that you can find tickets from as low as $108 on this airline. Additional options worth looking into are Delta and United Airlines, starting at $130 and $260 round-trip. Allegiant Air is 65% cheaper than the average price of flights available within the next 90 days to this destination.
What are the cheapest airlines to fly from Des Moines to Santa Ana, California one-way?
To fly one-way, consider booking your trip with Allegiant Air, which is currently one of the cheapest options available, starting at $92. Frontier flights start at $97 while deals on United Airlines start at $177 one-way.
What are the cheapest flights from Des Moines to Santa Ana, California?
On average you can expect to pay $187 for a flight from Des Moines to Santa Ana, California. The cheapest flight overall is $91 while the most popular route, (Des Moines - Santa Ana J. Wayne/Orange Cnty) is currently priced at $160.
Can I find deals for flights from Des Moines to Santa Ana that include hotel bookings?
Yes. In addition to deals on Des Moines to Santa Ana flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Des Moines to Santa Ana?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Santa Ana.
Can I find deals for business class flights from Des Moines to Santa Ana?
Yes. Cheapflights offers flight deals from Des Moines to Santa Ana by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Des Moines to Santa Ana, California?
Currently, May is the cheapest month in which you can book a flight from Des Moines to Santa Ana, California (average of $101). Flying from Des Moines to Santa Ana, California in July is currently the most expensive (average of $235). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Tustin

Browse thousands of different options on Cheapflights for your next trip

Top 5 airlines flying from Des Moines to Santa Ana

Airline	Cheapest	Average	Flexibility	On-time
Allegiant Air	Cheapest$108	Average$220	FlexibilityNo cancel fee	On-time88%
Delta	Cheapest$130	Average$326	FlexibilityNo cancel fee	On-timeN/A
United Airlines	Cheapest$260	Average$459	FlexibilityNo cancel fee	On-time69%
American Airlines	Cheapest$286	Average$406	FlexibilityNo cancel fee	On-time71%
Southwest	Cheapest$340	Average$486	FlexibilityNo cancel fee	On-time63%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.

$84+ Cheap flights from Des Moines to Santa Ana, CA (DSM - SNA)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/9. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Des Moines to Santa Ana with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheapflights Tip: The best prices from Des Moines to Santa Ana J. Wayne/Orange Cnty are usually found in September or April, booked 77 days in advance, depart on a Sunday or Thursday and return on a Wednesday

Cheap flight deals from Des Moines to Santa Ana

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Popular in

Cheapest in

Average price

Good round-trip deal

Good one-way deal

Find flight deals from Des Moines to Santa Ana

Cheapest flights from Des Moines to Santa AnaExplore the most affordable flight options available from Des Moines to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2025.

Explore the most affordable flight options available from Des Moines to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Des Moines to Santa Ana that are best for you.

Compare providers for flights from Des Moines to Santa Ana

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santa Ana in October.

Best time to book a flight from Des Moines to Santa Ana

Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Des Moines with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Santa Ana

How far ahead should I book a flight from Des Moines to Santa Ana, California?

What is the cheapest month to book a flight from Des Moines to Santa Ana, California?

What is the cheapest time of day to fly from DSM to SNA?

Reviews of airlines servicing Santa Ana

Read through reviews of airlines operating flights from Des Moines to Santa Ana, such as Southwest, Delta, and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How popular is this Des Moines to Santa Ana, California flight route?

How long is the flight from Des Moines to Santa Ana, California?

What are the cheapest airlines flying from Des Moines to Santa Ana, California round-trip?

What are the cheapest airlines to fly from Des Moines to Santa Ana, California one-way?

What are the cheapest flights from Des Moines to Santa Ana, California?

Can I find deals for flights from Des Moines to Santa Ana that include hotel bookings?

How can I find direct flights from Des Moines to Santa Ana?

Can I find deals for business class flights from Des Moines to Santa Ana?

What is the cheapest month to book a flight from Des Moines to Santa Ana, California?

Traveling to a place near Santa Ana?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Des Moines to Santa Ana

See prices for flight routes from nearby airports that may be better suited for you.

Top 5 airlines flying from Des Moines to Santa Ana

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Des Moines to Santa Ana
Explore the most affordable flight options available from Des Moines to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 14, 2025.