$95+ Cheap flights from Des Moines to Santa Ana (DSM - SNA)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/6. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SNA
Apr 21 — Apr 281
Round-trip
1 adult, Economy
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Find cheap flights from Des Moines to Santa Ana with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Des Moines to Santa Ana J. Wayne/Orange Cnty are usually found in September or January, booked 30 days in advance, depart on a Wednesday or Thursday and return on a Monday
Cheap flight deals from Des Moines to Santa Ana
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to Santa AnaExplore the most affordable flight options available from Des Moines to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 22, 2026.
Explore the most affordable flight options available from Des Moines to Santa Ana. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 22, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1110:00 am
DSM
- SNA
Nonstop3h 51m
Allegiant Air
Thu 5/2110:32 am
SNA
- DSM
Nonstop3h 19m
Allegiant Air
Deal found 3/21![Allegiant Air logo]()
$140
This Cheapflightsfares deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:00 am
DSM
- SNA
Nonstop3h 51m
Allegiant Air
Fri 4/1012:41 pm
SNA
- DSM
Nonstop3h 17m
Allegiant Air
Deal found 3/22![Allegiant Air logo]()
$163
This Cheapflightsfares deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/19:45 am
DSM
- SNA
Nonstop3h 51m
Allegiant Air
Mon 5/412:26 pm
SNA
- DSM
Nonstop3h 17m
Allegiant Air
Deal found 3/19![Allegiant Air logo]()
$184
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/410:00 am
DSM
- SNA
1 stop27h 28m
Allegiant Air
Fri 4/1012:41 pm
SNA
- DSM
Nonstop3h 17m
Allegiant Air
Deal found 3/17![Allegiant Air logo]()
$203
This Kiwi.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/1110:00 am
DSM
- SNA
Nonstop3h 51m
Multiple Airlines
Thu 5/218:10 pm
SNA
- DSM
1 stop22h 42m
Multiple Airlines
Deal found 3/21![Multiple Airlines logo]()
$205
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/69:45 pm
DSM
- SNA
1 stop19h 48m
Multiple Airlines
Fri 4/1012:41 pm
SNA
- DSM
Nonstop3h 17m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$211
Best flights from Des Moines to Santa AnaDiscover carefully curated flight deals from Des Moines to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 22, 2026.
Discover carefully curated flight deals from Des Moines to Santa Ana that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated March 22, 2026.
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/44:40 pm
DSM
- SNA
2 stops7h 45m
Southwest
Mon 6/811:50 am
SNA
- DSM
2 stops8h 30m
Southwest
Deal found 3/18![Southwest logo]()
$441
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/85:30 am
DSM
- SNA
1 stop6h 14m
United Airlines
Fri 4/102:40 pm
SNA
- DSM
1 stop6h 37m
United Airlines
Deal found 3/17![United Airlines logo]()
$443
This Southwest deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:15 am
DSM
- SNA
1 stop5h 10m
Southwest
Sat 8/226:45 am
SNA
- DSM
1 stop5h 25m
Southwest
Deal found 3/22![Southwest logo]()
$447
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:17 pm
DSM
- SNA
1 stop6h 40m
United Airlines
Fri 5/82:35 pm
SNA
- DSM
1 stop6h 49m
United Airlines
Deal found 3/17![United Airlines logo]()
$469
This Southwest deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/244:20 pm
DSM
- SNA
2 stops8h 00m
Southwest
Mon 4/2712:00 pm
SNA
- DSM
2 stops7h 55m
Southwest
Deal found 3/17![Southwest logo]()
$479
This United Airlines deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/245:17 pm
DSM
- SNA
1 stop5h 30m
United Airlines
Mon 4/277:44 pm
SNA
- DSM
2 stops13h 00m
United Airlines
Deal found 3/17![United Airlines logo]()
$484
This Southwest deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/57:20 am
DSM
- SNA
2 stops9h 25m
Southwest
Mon 9/76:45 am
SNA
- DSM
1 stop5h 00m
Southwest
Deal found 3/18![Southwest logo]()
$482
This Southwest deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:50 am
DSM
- SNA
2 stops8h 40m
Southwest
Fri 4/2412:00 pm
SNA
- DSM
2 stops7h 55m
Southwest
Deal found 3/20![Southwest logo]()
$487
Last-minute flights from Des Moines to Santa AnaDiscover last-minute flight deals from Des Moines to Santa Ana. Data last updated March 22, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to Santa Ana. Data last updated March 22, 2026 and is based on user searches.
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/410:00 am
DSM
- SNA
1 stop27h 28m
Allegiant Air
Fri 4/1012:41 pm
SNA
- DSM
Nonstop3h 17m
Allegiant Air
Deal found 3/17![Allegiant Air logo]()
$203
This Cheapflightsfares deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:00 am
DSM
- SNA
Nonstop3h 51m
Allegiant Air
Fri 4/1012:41 pm
SNA
- DSM
Nonstop3h 17m
Allegiant Air
Deal found 3/17![Allegiant Air logo]()
$155
This Kiwi.com deal was found by Cheapflights users on 3/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/69:45 pm
DSM
- SNA
1 stop19h 48m
Multiple Airlines
Fri 4/1012:41 pm
SNA
- DSM
Nonstop3h 17m
Multiple Airlines
Deal found 3/17![Multiple Airlines logo]()
$211
This Cheapflightsfares deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1710:00 am
DSM
- SNA
Nonstop3h 51m
Allegiant Air
Fri 4/2412:26 pm
SNA
- DSM
Nonstop3h 17m
Allegiant Air
Deal found 3/18![Allegiant Air logo]()
$215
This Kiwi.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/279:45 am
DSM
- SNA
Nonstop3h 51m
Multiple Airlines
Thu 4/303:23 pm
SNA
- DSM
1 stop28h 01m
Multiple Airlines
Deal found 3/20![Multiple Airlines logo]()
$226
One-way flights from Des Moines to Santa AnaSearch for one-way flight options from Des Moines to Santa Ana. Find affordable one-way fares based on user searches. Data last updated March 22, 2026.
Search for one-way flight options from Des Moines to Santa Ana. Find affordable one-way fares based on user searches. Data last updated March 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/68:00 am
DSM
- SNA
Nonstop3h 51m
Allegiant Air
Deal found 3/19![Allegiant Air logo]()
$95
This Kiwi.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/1010:11 pm
DSM
- SNA
1 stop13h 42m
Multiple Airlines
Deal found 3/20![Multiple Airlines logo]()
$113
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 3/277:00 am
DSM
- SNA
Nonstop3h 55m
Allegiant Air
Deal found 3/18![Allegiant Air logo]()
$119
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/159:56 pm
DSM
- SNA
1 stop19h 27m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$125
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/69:45 pm
DSM
- SNA
1 stop19h 48m
Multiple Airlines
Deal found 3/19![Multiple Airlines logo]()
$127
This Super.com deal was found by Cheapflights users on 3/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Super.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/288:21 pm
DSM
- SNA
1 stop16h 26m
Frontier
Deal found 3/21![Frontier logo]()
$129
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/242:04 pm
DSM
- SNA
1 stop23h 21m
Frontier
Deal found 3/18![Frontier logo]()
$130
This Kiwi.com deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/311:00 am
DSM
- SNA
1 stop23h 05m
Multiple Airlines
Deal found 3/19![Multiple Airlines logo]()
$135
This Kiwi.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/27:00 am
DSM
- SNA
Nonstop3h 33m
Allegiant Air
Deal found 3/20![Allegiant Air logo]()
$138
This Kiwi.com deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/297:30 am
DSM
- SNA
1 stop28h 23m
Multiple Airlines
Deal found 3/18![Multiple Airlines logo]()
$143
This Cheapflightsfares deal was found by Cheapflights users on 3/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/249:45 am
DSM
- SNA
Nonstop3h 51m
Allegiant Air
Deal found 3/18![Allegiant Air logo]()
$149
This Kiwi.com deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/222:16 pm
DSM
- SNA
1 stop20h 53m
Frontier
Deal found 3/20![Frontier logo]()
$153
Find flight deals from Des Moines to Santa Ana
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to Santa Ana (SNA). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $140 (Cheapflightsfares) |
One-way from | $95 (Kiwi.com) |
Popular in | March |
Cheapest in | September |
Average price | $520 |
Good round-trip deal | $208 or less |
Good one-way deal | $162 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to Santa Ana that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 22, 2026.
Use the filters below to find and compare flights from Des Moines to Santa Ana that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Thu 6/4
4:40 pm-10:25 pm
2 stops7h 45m
Santa Ana J. Wayne/Orange Cnty
Mon 6/8
11:50 am-10:20 pm
2 stops8h 30m
$441
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Wed 4/8
5:30 am-9:44 am
1 stop6h 14m
Santa Ana J. Wayne/Orange Cnty
Fri 4/10
2:40 pm-11:17 pm
1 stop6h 37m
$443
Quickest round-trip
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Tue 8/11
7:15 am-10:25 am
1 stop5h 10m
Santa Ana J. Wayne/Orange Cnty
Sat 8/22
6:45 am-2:10 pm
1 stop5h 25m
$447
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Mon 5/4
5:17 pm-9:57 pm
1 stop6h 40m
Santa Ana J. Wayne/Orange Cnty
Fri 5/8
2:35 pm-11:24 pm
1 stop6h 49m
$469
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Fri 4/24
4:20 pm-10:20 pm
2 stops8h 00m
Santa Ana J. Wayne/Orange Cnty
Mon 4/27
12:00 pm-9:55 pm
2 stops7h 55m
$479
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Sat 9/5
7:20 am-2:45 pm
2 stops9h 25m
Santa Ana J. Wayne/Orange Cnty
Mon 9/7
6:45 am-1:45 pm
1 stop5h 00m
$482
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Fri 4/24
5:17 pm-8:47 pm
1 stop5h 30m
Santa Ana J. Wayne/Orange Cnty
Mon 4/27
7:44 pm-10:44 am
2 stops13h 00m
$484
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Fri 4/17
6:50 am-1:30 pm
2 stops8h 40m
Santa Ana J. Wayne/Orange Cnty
Fri 4/24
12:00 pm-9:55 pm
2 stops7h 55m
$487
Cheapest one-way
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Mon 6/15
9:56 pm-3:23 pm
1 stop19h 27m
$125
Des MoinesSanta Ana
DSM - SNA
DSMSNA
Des Moines
Sun 6/7
8:36 pm-12:19 pm
1 stop17h 43m
$155
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Des Moines to Santa Ana
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to Santa Ana in March.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*2 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-Santa Ana flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-Santa Ana flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-Santa Ana flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-Santa Ana flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-Santa Ana flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to Santa Ana
Have a flexible travel schedule? Discover the best time to fly to Santa Ana from Des Moines with our price prediction graph.
DSM-SNA
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to Santa Ana
How far ahead should I book a flight from Des Moines to Santa Ana?
Use this chart to determine the optimal time to book a round-trip flight from Des Moines to Santa Ana. Price data was last updated on March 13, 2026.
To ensure you get the cheapest price possible for a flight from Des Moines to Santa Ana, you should look to book at least 30 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from Des Moines to Santa Ana?
Currently, May is the cheapest month in which you can book a flight from Des Moines to Santa Ana (average of $95). Flying from Des Moines to Santa Ana in December is currently the most expensive (average of $228). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from DSM to SNA?
Find hourly flight availability from Des Moines to Santa Ana. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated March 22, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Santa Ana as you normally would.
Reviews of airlines servicing Santa Ana
Get insights into the airlines that provide service to Santa Ana. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Ana. Reviews last updated March 22, 2026.
Read through reviews of airlines operating flights from Des Moines to Santa Ana, such as Southwest,Delta, andUnited Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Crew
8.6
Entertainment
7.5
Overall
8.0
Boarding
8.1
Food
7.0
Comfort
8.0
Reviews
1 / 20
2.0
MediocreDominic,Mar 2026
MCO - SMF
Related info for your journey
Find useful and relevant information for your journey from Des Moines to Santa Ana. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Book flights to Santa Ana if you plan to visit one of these locationsTustin
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Find flights from Des Moines to Santa Ana, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and Santa Ana flights
Browse other Des Moines and Santa Ana flight options. Last updated on March 22, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on March 22, 2026.
Popular flight searches
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Other flights to Santa Ana
Explore flights to Santa Ana departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on March 22, 2026.
Top 5 airlines flying from Des Moines to Santa Ana
Discover the top 5 airlines that operate flights from Des Moines to Santa Ana. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$108 | Average$196 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$130 | Average$273 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$253 | Average$426 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$286 | Average$398 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$340 | Average$476 | FlexibilityNo cancel fee | On-time63% |