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$346+ Cheap flights from Florence, SC to San Francisco (FLO - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/2. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — SFO
Apr 21 — Apr 281
Tue 4/21
Tue 4/28
1 adult, Economy
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Cheap flight deals from Florence to San Francisco

Cheapest flights from Florence to San Francisco
Explore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on March 22, 2026.

This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/134:16 pm
FLO
-
SFO
1 stop9h 59m
American Airlines
Fri 4/179:08 am
SFO
-
FLO
1 stop9h 39m
American Airlines
Deal found 3/19$517
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/46:25 pm
FLO
-
SFO
1 stop7h 45m
American Airlines
Wed 4/89:08 am
SFO
-
FLO
1 stop9h 39m
American Airlines
Deal found 3/20$577
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/36:20 pm
FLO
-
SFO
1 stop7h 50m
American Airlines
Mon 4/612:59 am
SFO
-
FLO
2 stops11h 33m
American Airlines
Deal found 3/19$582
This American Airlines deal was found by Cheapflights users on 3/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/142:34 pm
FLO
-
SFO
1 stop8h 55m
American Airlines
Fri 8/2111:30 pm
SFO
-
FLO
1 stop8h 20m
American Airlines
Deal found 3/19$589
This American Airlines deal was found by Cheapflights users on 3/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/66:20 pm
FLO
-
SFO
1 stop7h 50m
American Airlines
Fri 4/105:30 am
SFO
-
FLO
2 stops13h 17m
American Airlines
Deal found 3/22$794
This American Airlines deal was found by Cheapflights users on 3/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/44:16 pm
FLO
-
SFO
1 stop23h 16m
American Airlines
Mon 5/1110:28 pm
SFO
-
FLO
1 stop14h 04m
American Airlines
Deal found 3/20$842

Find flight deals from Florence to San Francisco

Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to San Francisco (SFO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated March 22, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$517
(American Airlines)

One-way from

$346
(American Airlines)
Provider with most accurate pricing for Florence-San Francisco flight deals.
Search Deals
Provider most trusted by Cheapflights users for Florence-San Francisco flights.
Search Deals
From Florence to San Francisco
Search Deals
One-way flight from Florence to San Francisco
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to San Francisco that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 22, 2026.
Use the filters below to find and compare flights from Florence to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Mon 4/13

4:16 pm-11:15 pm

1 stop9h 59m

San Francisco

Fri 4/17

9:08 am-9:47 pm

1 stop9h 39m

$517

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Mon 4/6

6:20 pm-11:10 pm

1 stop7h 50m

San Francisco

Fri 4/10

9:08 am-9:47 pm

1 stop9h 39m

$577
Quickest round-trip

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sat 4/4

6:25 pm-11:10 pm

1 stop7h 45m

San Francisco

Wed 4/8

9:08 am-9:47 pm

1 stop9h 39m

$577

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Fri 4/3

6:20 pm-11:10 pm

1 stop7h 50m

San Francisco

Mon 4/6

12:59 am-3:32 pm

2 stops11h 33m

$582

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Fri 8/14

11:15 am-7:16 pm

2 stops11h 01m

San Francisco

Fri 8/21

7:54 pm-10:50 am

2 stops11h 56m

$600

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Mon 5/4

4:16 pm-12:32 pm

1 stop23h 16m

San Francisco

Mon 5/11

10:28 pm-3:32 pm

1 stop14h 04m

$842
Cheapest one-way

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Wed 6/3

2:35 pm-12:08 am

2 stops12h 33m

$351
Quickest one-way

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Fri 6/5

2:35 pm-9:19 pm

1 stop9h 44m

$436

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Mon 6/1

2:35 pm-8:34 am

2 stops20h 59m

$584

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/20

Sorted by cheapest first

Compare providers for flights from Florence to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Florence to San Francisco in March.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
ExpediaPrice Accuracy1 starTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Florence, South Carolina-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Florence, South Carolina-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Florence, South Carolina-San Francisco flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Florence, South Carolina-San Francisco flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Florence, South Carolina-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Florence to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to San Francisco

What is the cheapest month to book a flight from Florence, South Carolina to San Francisco?

Currently, August is the cheapest month in which you can book a flight from Florence, South Carolina to San Francisco (average of $106). Flying from Florence, South Carolina to San Francisco in February is currently the most expensive (average of $261). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Francisco

Get insights into the airlines that provide service to San Francisco. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Francisco. Reviews last updated March 22, 2026.
Peruse reviews from past customers who have flown with American Airlines from Florence to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,488 reviews

Boarding

7.5

Comfort

7.2

Food

6.4

Entertainment

6.9

Crew

7.9

Overall

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes
American Airlines
7.1
Good
11,488 reviews
American Airlines
7.1
Good
11,488 reviews

Boarding

7.5

Comfort

7.2

Food

6.4

Entertainment

6.9

Crew

7.9

Overall

7.1

Reviews

1 / 20
2.0
Mediocre

Anonymous,Mar 2026

MIA - SFO

Horrible. When they power flights for other airlines there is nothing they can do to change or accommodate any changes

Related info for your journey

Find useful and relevant information for your journey from Florence to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Florence, South Carolina to San Francisco?

    A quick flight from Florence, South Carolina to San Francisco can take about 9h 59m. American Airlines provides one of the quickest options available for as low as $517. Florence, South Carolina and San Francisco are separated by a distance of 2377 mi.

  • Can I find deals for flights from Florence to San Francisco that include hotel bookings?

    Yes. In addition to deals on Florence to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to San Francisco?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to San Francisco.

  • Can I find deals for business class flights from Florence to San Francisco?

    Yes. Cheapflights offers flight deals from Florence to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Florence, South Carolina to San Francisco?

    Currently, August is the cheapest month in which you can book a flight from Florence, South Carolina to San Francisco (average of $106). Flying from Florence, South Carolina to San Francisco in February is currently the most expensive (average of $261). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Francisco?

Book flights to San Francisco if you plan to visit one of these locations
South San Francisco
Santa Clara
Santa Cruz
Livermore
Roseville
Watsonville
Rancho Cordova
San Bruno
San Ramon
Sunnyvale
Vacaville
San Carlos
Redwood City
Turlock
San Lorenzo
Davis
Manteca
Union City
Elk Grove
Rohnert Park

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Top airline flying from Florence to San Francisco

Discover the top airline that operate flights from Florence to San Francisco. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated March 22, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$412Average$503FlexibilityNo cancel feeOn-time71%

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