How long is the flight from Florence, South Carolina to San Francisco?

A quick flight from Florence, South Carolina to San Francisco can take about 7h 49m. American Airlines provides one of the quickest options available for as low as $557. Florence, South Carolina and San Francisco are separated by a distance of 2377 mi.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What is the cheapest time of day to fly from FLO to SFO?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florence, South Carolina to San Francisco as you normally would.

Most accurate provider : When it comes to deals on Florence, South Carolina-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Florence, South Carolina-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Florence, South Carolina-San Francisco flight searches over the past month and is updated monthly.

Most trusted provider : When it comes to deals on Florence, South Carolina-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Florence, South Carolina-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Can I find deals for flights from Florence to San Francisco that include hotel bookings?

Yes. In addition to deals on Florence to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Florence to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to San Francisco.

Can I find deals for business class flights from Florence to San Francisco?

Yes. Cheapflights offers flight deals from Florence to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$249+ Flights from Florence, SC to San Francisco

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Cheap flight deals from Florence to San Francisco

Cheapest flights from Florence to San Francisco
Explore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 20, 2026.

Mon 2/25:36 pm

FLO

SFO

1 stop7h 52m

American Airlines

Fri 2/67:00 am

SFO

FLO

1 stop7h 09m

American Airlines

Deal found 1/18

$557

Best flights from Florence to San Francisco
Discover carefully curated flight deals from Florence to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated January 20, 2026.

Wed 2/45:36 pm

FLO

SFO

1 stop7h 49m

American Airlines

Sun 2/87:00 am

SFO

FLO

1 stop7h 09m

American Airlines

Deal found 1/19

$557

Mon 2/25:36 pm

FLO

SFO

1 stop7h 52m

American Airlines

Fri 2/67:00 am

SFO

FLO

1 stop7h 09m

American Airlines

Deal found 1/18

$557

Last-minute flights from Florence to San Francisco
Discover last-minute flight deals from Florence to San Francisco. Data last updated January 20, 2026 and is based on user searches.

Mon 2/25:36 pm

FLO

SFO

1 stop7h 52m

American Airlines

Fri 2/67:00 am

SFO

FLO

1 stop7h 09m

American Airlines

Deal found 1/18

$557

One-way flights from Florence to San Francisco
Search for one-way flight options from Florence to San Francisco. Find affordable one-way fares based on user searches. Data last updated January 20, 2026.

Sun 2/155:16 am

FLO

SFO

1 stop10h 01m

American Airlines

Deal found 1/19

$249

Tue 1/276:15 am

FLO

SFO

1 stop10h 35m

American Airlines

Deal found 1/20

$350

Find flight deals from Florence to San Francisco

Most accurate provider	FlightHub 3 stars
Most trusted provider	Expedia 3 stars
Round-trip from	$557 (American Airlines)
One-way from	$249 (American Airlines)

Provider with most accurate pricing for Florence-San Francisco flight deals.

Search Deals

Provider most trusted by Cheapflights users for Florence-San Francisco flights.

Search Deals

From Florence to San Francisco

Search Deals

One-way flight from Florence to San Francisco

Search Deals

Cheapflights Fare Finder

Use the filters below to find and compare flights from Florence to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Wed 2/4

5:36 pm-10:25 pm

1 stop7h 49m

San Francisco

Sun 2/8

7:00 am-5:09 pm

1 stop7h 09m

$557

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Mon 2/2

5:36 pm-10:28 pm

1 stop7h 52m

San Francisco

Fri 2/6

7:00 am-5:09 pm

1 stop7h 09m

$557

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sun 2/15

5:16 am-12:17 pm

1 stop10h 01m

$249

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Tue 1/27

6:15 am-1:50 pm

1 stop10h 35m

$350

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/19

Compare providers for flights from Florence to San Francisco

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Florence to San Francisco in January.

Provider	Price Accuracy	Trust Score*
Expedia	Price Accuracy2 stars	Trust Score*3 stars
FlightHub	Price Accuracy3 stars	Trust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

Most accurate provider: When it comes to deals on Florence, South Carolina-San Francisco flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Florence, South Carolina-San Francisco flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Florence, South Carolina-San Francisco flight searches over the past month and is updated monthly.
Most trusted provider: When it comes to deals on Florence, South Carolina-San Francisco flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Florence, South Carolina-San Francisco flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Florence to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Florence with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to San Francisco

What is the cheapest month to book a flight from Florence, South Carolina to San Francisco?

Currently, August is the cheapest month in which you can book a flight from Florence, South Carolina to San Francisco (average of $106). Flying from Florence, South Carolina to San Francisco in June is currently the most expensive (average of $202). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Francisco

Peruse reviews from past customers who have flown with American Airlines from Florence to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

American Airlines

7.2

Good

11,164 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,Apr 2025

MYR - CLT

This flight was impacted by a nearly 4, yes 4 hour delay. They replaced a 777 with another one and it had to be cleaned and catered before we could depart. Great crew did it without complaint.

American Airlines

7.2

Good

11,164 reviews

American Airlines

7.2

Good

11,164 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,Apr 2025

MYR - CLT

This flight was impacted by a nearly 4, yes 4 hour delay. They replaced a 777 with another one and it had to be cleaned and catered before we could depart. Great crew did it without complaint.

Related info for your journey

How long is the flight from Florence, South Carolina to San Francisco?
A quick flight from Florence, South Carolina to San Francisco can take about 7h 49m. American Airlines provides one of the quickest options available for as low as $557. Florence, South Carolina and San Francisco are separated by a distance of 2377 mi.
Can I find deals for flights from Florence to San Francisco that include hotel bookings?
Yes. In addition to deals on Florence to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Florence to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to San Francisco.
Can I find deals for business class flights from Florence to San Francisco?
Yes. Cheapflights offers flight deals from Florence to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Florence, South Carolina to San Francisco?
Currently, August is the cheapest month in which you can book a flight from Florence, South Carolina to San Francisco (average of $106). Flying from Florence, South Carolina to San Francisco in June is currently the most expensive (average of $202). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

South San Francisco

Santa Cruz

Roseville

Santa Clara

Livermore

Watsonville

San Bruno

Daly City

Sunnyvale

Vacaville

Turlock

San Carlos

San Ramon

Manteca

Vallejo

San Lorenzo

Davis

Hollister

Redwood City

Union City

Browse thousands of different options on Cheapflights for your next trip

Top airline flying from Florence to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$326	Average$416	FlexibilityNo cancel fee	On-time71%

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$249+ Cheap flights from Florence, SC to San Francisco (FLO - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/15. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Florence to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Florence to San Francisco

Cheapest flights from Florence to San FranciscoExplore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 20, 2026.

Explore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 20, 2026.

Find flight deals from Florence to San Francisco

Most accurate provider

Most trusted provider

Round-trip from

One-way from

Cheapflights Fare Finder

Use the filters below to find and compare flights from Florence to San Francisco that are best for you.

Compare providers for flights from Florence to San Francisco

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.

Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Florence to San Francisco in January.

Best time to book a flight from Florence to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Florence with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Florence to San Francisco

What is the cheapest month to book a flight from Florence, South Carolina to San Francisco?

Reviews of airlines servicing San Francisco

Peruse reviews from past customers who have flown with American Airlines from Florence to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Florence to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Florence, South Carolina to San Francisco?

Can I find deals for flights from Florence to San Francisco that include hotel bookings?

How can I find direct flights from Florence to San Francisco?

Can I find deals for business class flights from Florence to San Francisco?

What is the cheapest month to book a flight from Florence, South Carolina to San Francisco?

Traveling to a place near San Francisco?

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Florence to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Florence to San Francisco

100% Free

Book with Flexibility

Travel Smart

Cheapest flights from Florence to San Francisco
Explore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 20, 2026.