What is the cheapest time of day to fly from FLO to SFO?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florence, South Carolina to San Francisco as you normally would.

Can I find deals for flights from Florence to San Francisco that include hotel bookings?

Yes. In addition to deals on Florence to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Florence to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to San Francisco.

Can I find deals for business class flights from Florence to San Francisco?

Yes. Cheapflights offers flight deals from Florence to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$209+ Flights from Florence, SC to San Francisco

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Cheap flight deals from Florence to San Francisco

Round-trip from	$315 (American Airlines)

From Florence to San Francisco

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Find flight deals from Florence to San Francisco

Cheapest flights from Florence to San Francisco
Explore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Sat 9/206:14 amFLO - SFO

1 stop8h 16mAmerican Airlines

Sat 9/2711:52 pmSFO - FLO

1 stop8h 03mAmerican Airlines

Deal found 6/11

$315

Best flights from Florence to San Francisco
Discover carefully curated flight deals from Florence to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 12, 2025.

Sat 9/206:14 amFLO - SFO

1 stop8h 16mAmerican Airlines

Sat 9/2711:52 pmSFO - FLO

1 stop8h 03mAmerican Airlines

Deal found 6/11

$315

Cheapflights Fare Finder

Use the filters below to find and compare flights from Florence to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sat 9/20

6:14 am-11:30 am

1 stop8h 16m

San Francisco

Sat 9/27

11:52 pm-10:55 am

1 stop8h 03m

$315

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Fri 10/3

12:27 pm-6:36 pm

1 stop9h 09m

$209

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/10

Best time to book a flight from Florence to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Florence with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to San Francisco

What is the cheapest month to book a flight from Florence, South Carolina to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Florence, South Carolina to San Francisco (average of $276). Flying from Florence, South Carolina to San Francisco in June is currently the most expensive (average of $364). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Rainfall in San Francisco by month

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

Temperature in San Francisco by month

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

Reviews of airlines servicing San Francisco

American Airlines

7.2

Good

10,000 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,Apr 2025

MYR - CLT

This flight was impacted by a nearly 4, yes 4 hour delay. They replaced a 777 with another one and it had to be cleaned and catered before we could depart. Great crew did it without complaint.

American Airlines

7.2

Good

10,000 reviews

American Airlines

7.2

Good

10,000 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,Apr 2025

MYR - CLT

This flight was impacted by a nearly 4, yes 4 hour delay. They replaced a 777 with another one and it had to be cleaned and catered before we could depart. Great crew did it without complaint.

Related info for your journey

Can I find deals for flights from Florence to San Francisco that include hotel bookings?
Yes. In addition to deals on Florence to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Florence to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to San Francisco.
Can I find deals for business class flights from Florence to San Francisco?
Yes. Cheapflights offers flight deals from Florence to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Florence, South Carolina to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Florence, South Carolina to San Francisco (average of $276). Flying from Florence, South Carolina to San Francisco in June is currently the most expensive (average of $364). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Roseville

Mountain View

South San Francisco

Livermore

Turlock

Santa Cruz

Manteca

Fairfield

Watsonville

Antioch

Hollister

Milpitas

Newark

Hayward

Alameda

Sunnyvale

Daly City

Union City

Campbell

Capitola

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Top airline flying from Florence to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$326	Average$412	FlexibilityNo cancel fee	On-time71%

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$209+ Cheap flights from Florence, SC to San Francisco (FLO - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/3. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Florence to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Florence to San Francisco

Round-trip from

Find flight deals from Florence to San Francisco

Cheapest flights from Florence to San FranciscoExplore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Explore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Florence to San Francisco that are best for you.

Best time to book a flight from Florence to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Florence with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Florence to San Francisco

What is the cheapest month to book a flight from Florence, South Carolina to San Francisco?

Rainfall in San Francisco by month

Plan your trip to San Francisco by taking into account the average rainfall totals by month.

Temperature in San Francisco by month

Plan your trip to San Francisco by taking into account the average temperature totals by month.

Reviews of airlines servicing San Francisco

Related info for your journey

Find useful and relevant information for your journey from Florence to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

Can I find deals for flights from Florence to San Francisco that include hotel bookings?

How can I find direct flights from Florence to San Francisco?

Can I find deals for business class flights from Florence to San Francisco?

What is the cheapest month to book a flight from Florence, South Carolina to San Francisco?

Traveling to a place near Florence?

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Alternative routes for Florence to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Florence to San Francisco

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Book with Flexibility

Travel Smart

Cheapest flights from Florence to San Francisco
Explore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2025.