How long is the flight from Florence, South Carolina to San Francisco?

A quick flight from Florence, South Carolina to San Francisco can take about 10h 53m. American Airlines provides one of the quickest options available for as low as $487. Florence, South Carolina and San Francisco are separated by a distance of 2377 mi.

In terms of precipitation, rainfall in San Francisco ranges from 0.0 - 4.4 inches per month. January is typically the wettest month, when rainfall can reach 4.4 in. July is typically the driest time to visit San Francisco when rainfall is around 0.0 in.

If weather is an important factor for your trip to San Francisco, use this chart to help with planning. For those seeking warmer temperatures, September is the ideal time of year to visit, when temperatures reach an average of 62.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 51.8 F).

What is the cheapest time of day to fly from FLO to SFO?

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Florence, South Carolina to San Francisco as you normally would.

Can I find deals for flights from Florence to San Francisco that include hotel bookings?

Yes. In addition to deals on Florence to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.

How can I find direct flights from Florence to San Francisco?

After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to San Francisco.

Can I find deals for business class flights from Florence to San Francisco?

Yes. Cheapflights offers flight deals from Florence to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

$189+ Flights from Florence, SC to San Francisco

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Cheap flight deals from Florence to San Francisco

Round-trip from	$487 (American Airlines)
One-way from	$189 (American Airlines)

From Florence to San Francisco

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One-way flight from Florence to San Francisco

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Find flight deals from Florence to San Francisco

Cheapest flights from Florence to San Francisco
Explore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

Tue 9/306:14 amFLO - SFO

1 stop8h 16mAmerican Airlines

Sat 10/412:38 pmSFO - FLO

1 stop7h 38mAmerican Airlines

Deal found 9/15

$519

Best flights from Florence to San Francisco
Discover carefully curated flight deals from Florence to San Francisco that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated September 16, 2025.

Sat 3/1411:09 amFLO - SFO

1 stop10h 53mAmerican Airlines

Mon 3/2312:25 amSFO - FLO

1 stop6h 59mAmerican Airlines

Deal found 9/14

$487

Wed 3/411:11 amFLO - SFO

1 stop11h 05mAmerican Airlines

Sat 3/71:56 pmSFO - FLO

1 stop6h 33mAmerican Airlines

Deal found 9/14

$507

Tue 9/306:14 amFLO - SFO

1 stop8h 16mAmerican Airlines

Sat 10/412:38 pmSFO - FLO

1 stop7h 38mAmerican Airlines

Deal found 9/15

$519

Last-minute flights from Florence to San Francisco
Discover last-minute flight deals from Florence to San Francisco. Data last updated September 16, 2025 and is based on user searches.

Tue 9/306:14 amFLO - SFO

1 stop8h 16mAmerican Airlines

Sat 10/412:38 pmSFO - FLO

1 stop7h 38mAmerican Airlines

Deal found 9/15

$519

One-way flights from Florence to San Francisco
Search for one-way flight options from Florence to San Francisco. Find affordable one-way fares based on user searches. Data last updated September 16, 2025.

Wed 10/153:19 pmFLO - SFO

1 stop8h 25mAmerican Airlines

Deal found 9/13

$189

Sun 9/285:14 amFLO - SFO

1 stop10h 02mAmerican Airlines

Deal found 9/14

$319

Wed 9/246:14 amFLO - SFO

1 stop8h 16mAmerican Airlines

Deal found 9/14

$439

Cheapflights Fare Finder

Use the filters below to find and compare flights from Florence to San Francisco that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sat 3/14

11:09 am-7:02 pm

1 stop10h 53m

San Francisco

Mon 3/23

12:25 am-10:24 am

1 stop6h 59m

$487

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Wed 3/4

11:11 am-7:16 pm

1 stop11h 05m

San Francisco

Sat 3/7

1:56 pm-11:29 pm

1 stop6h 33m

$507

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Tue 9/30

6:14 am-11:30 am

1 stop8h 16m

San Francisco

Sat 10/4

12:38 pm-11:16 pm

1 stop7h 38m

$519

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Wed 10/15

3:19 pm-8:44 pm

1 stop8h 25m

$189

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Sun 9/28

5:14 am-12:16 pm

1 stop10h 02m

$319

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Wed 9/24

6:14 am-11:30 am

1 stop8h 16m

$439

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Thu 9/25

4:57 pm-9:51 pm

1 stop7h 54m

$439

FlorenceSan Francisco

FLO - SFO

FLOSFO

Florence

Fri 9/26

12:27 pm-6:36 pm

1 stop9h 09m

$439

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Best time to book a flight from Florence to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Florence with our price prediction graph.

Estimated round-trip price

Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to San Francisco

What is the cheapest month to book a flight from Florence, South Carolina to San Francisco?

Currently, January is the cheapest month in which you can book a flight from Florence, South Carolina to San Francisco (average of $276). Flying from Florence, South Carolina to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Reviews of airlines servicing San Francisco

Peruse reviews from past customers who have flown with American Airlines from Florence to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

American Airlines

7.2

Good

10,000 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,Apr 2025

MYR - CLT

This flight was impacted by a nearly 4, yes 4 hour delay. They replaced a 777 with another one and it had to be cleaned and catered before we could depart. Great crew did it without complaint.

American Airlines

7.2

Good

10,000 reviews

American Airlines

7.2

Good

10,000 reviews

Reviews

1 / 20

10.0

Excellent

Anonymous,Apr 2025

MYR - CLT

This flight was impacted by a nearly 4, yes 4 hour delay. They replaced a 777 with another one and it had to be cleaned and catered before we could depart. Great crew did it without complaint.

Related info for your journey

How long is the flight from Florence, South Carolina to San Francisco?
A quick flight from Florence, South Carolina to San Francisco can take about 10h 53m. American Airlines provides one of the quickest options available for as low as $487. Florence, South Carolina and San Francisco are separated by a distance of 2377 mi.
Can I find deals for flights from Florence to San Francisco that include hotel bookings?
Yes. In addition to deals on Florence to San Francisco flights, Cheapflights offers vacation packages that include both flights and hotel.
How can I find direct flights from Florence to San Francisco?
After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to San Francisco.
Can I find deals for business class flights from Florence to San Francisco?
Yes. Cheapflights offers flight deals from Florence to San Francisco by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.
What is the cheapest month to book a flight from Florence, South Carolina to San Francisco?
Currently, January is the cheapest month in which you can book a flight from Florence, South Carolina to San Francisco (average of $276). Flying from Florence, South Carolina to San Francisco in June is currently the most expensive (average of $357). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Roseville

Santa Cruz

Livermore

South San Francisco

Turlock

Antioch

Watsonville

Santa Clara

Manteca

Sunnyvale

Hollister

Vacaville

Foster City

Union City

Vallejo

Burlingame

Redwood City

San Mateo

San Leandro

Lathrop

Browse thousands of different options on Cheapflights for your next trip

Top airline flying from Florence to San Francisco

Airline	Cheapest	Average	Flexibility	On-time
American Airlines	Cheapest$326	Average$416	FlexibilityNo cancel fee	On-time71%

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$189+ Cheap flights from Florence, SC to San Francisco (FLO - SFO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.

Find cheap flights from Florence to San Francisco with Cheapflights

1. Tell us where you want to go

2. Select your favorite providers

3. Compare prices and book

Cheap flight deals from Florence to San Francisco

Round-trip from

One-way from

Find flight deals from Florence to San Francisco

Cheapest flights from Florence to San FranciscoExplore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

Explore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.

Cheapflights Fare Finder

Use the filters below to find and compare flights from Florence to San Francisco that are best for you.

Best time to book a flight from Florence to San Francisco

Have a flexible travel schedule? Discover the best time to fly to San Francisco from Florence with our price prediction graph.

Cheapflights Insights

Everything you need to know about your flight from Florence to San Francisco

What is the cheapest month to book a flight from Florence, South Carolina to San Francisco?

Reviews of airlines servicing San Francisco

Peruse reviews from past customers who have flown with American Airlines from Florence to San Francisco to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.

Related info for your journey

Find useful and relevant information for your journey from Florence to San Francisco. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

How long is the flight from Florence, South Carolina to San Francisco?

Can I find deals for flights from Florence to San Francisco that include hotel bookings?

How can I find direct flights from Florence to San Francisco?

Can I find deals for business class flights from Florence to San Francisco?

What is the cheapest month to book a flight from Florence, South Carolina to San Francisco?

Traveling to a place near San Francisco?

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Florence to San Francisco

See prices for flight routes from nearby airports that may be better suited for you.

Top airline flying from Florence to San Francisco

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Book with Flexibility

Travel Smart

Cheapest flights from Florence to San Francisco
Explore the most affordable flight options available from Florence to San Francisco. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 16, 2025.